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Research / Core Facilities

College of Medicine Research Core Facilities

The UC College of Medicine houses several research core facilities designated as core service centers. These facilities exist within multiple departments but are collectively supported by the College of Medicine Office of Research through the Associate Dean for Research Core Facilities: Ken Greis, PhD. (; Tel: 513-558-7102).

The service center designation signifies the rates charged by each of these facilities have been reviewed and approved by the UC Government Cost Compliance Office; thus, the service fees can be charged to federal grants and contracts. Details related to the services offered and the internal rates for each of the cores are provided below. Since these rates are substantially subsidized by the University, external investigators should contact individual core directors to get a rate quote.

Resources to offset some of the cost of the core services may be available through a variety of centers and institutes across UC depending on an investigator’s affiliation. Information for support from the CCTST is provided here:

UC invesitgators also hvae full access to shared resource cores at Cincinnati Children's Hospital. Details are provided here:

We have recently transitioned our core facilities booking and management to the PPMS system from Stratocore. To book and access services from the core facilities, please log in or create an account in Stratocore via:

My PPMS Dashboard

Stratocore Account Creation Guides:

Fernald Database and Biospecimens Service

Mission: To provide a mechanism for sharing data and biospecimen from a large longitudinal cohort as a resource to researchers for approved studies.
Description:  The Fernald Community Cohort consists of the 9782 persons who were enrolled in the Fernald Medical Monitoring Program (FMMP)(1990-2008). The comprehensive examinations conducted as part of the Fernald Medical Monitoring Program (FMMP) began in the autumn of 1990. The FMMP provided 9,782 initial examinations and 42,775 re-examinations over 18 years. An extensive computerized database and biospecimen repository was created to provide research resources for future studies. All questionnaire, examination and diagnostic procedure data collected from the FMMP were coded by certified medical record coders, double entered with verification into a SAS database on site of the examinations. Cryo-preserved blood and urine samples were collected at enrollment and at various intervals throughout follow-up.  At the first examination three 1-ml aliquots of whole blood, plasma, serum, urine and urine with buffer were obtained from each participant (15 aliquots per person) for future analyses.  Additional whole blood and serum was obtained in 1996-1997 and 2006-2008. Specimens have been stored in minus 80 degree freezers; over 160,000 biospecimens are in the archive. More information about the cohort and the “Access to Data and Biospecimen Policy” and application form can be found at

Data Preparation (per project)
Biospecimens (per Sample/Specimen)
Medical Records (per Record)
Research Consultations - Research Director (per Hour)
Research Consultations- Data Analyst (per Hour)
Research Consultations- Research Coordinator (per Hour)
Research Consultations - Clinical Research Assistant (per Hour)
Aliquot (per Sample)
Pass through- Supplies/ Postage (Pass through cost)
Fernald Database and Biospecimens Service Center Services
Past projects

A list of projects that have used Fernald Community Cohort Data and Biospecimens

Medical Heritage Project


Analysis of Laboratory Data


Lung Cancer Family Registry


Standardized Prevalence Ratio Analysis of Chronic Conditions, and Analysis of Selected Laboratory Tests, in Participants of the Fernald Medical Monitoring Program


Develop Yearly and Cumulative Radon Exposure Estimates to Former Fernald Workers, as well as Obtaining Their Smoking History.


Kidney Function of Persons with Contaminated Wells


Spatial Relationship Between 22 Urinary System Cancers and Likely Sources of Environmental Exposure in the Fernald Exposure Domain.


Breast Cancer Risk Factors and Mammogram Findings


Birth Weight and Sex Ratio in Offspring of FMMP Participants


Comparison of Women Who Do & Do not adhere to Healthcare recommendations


Develop new Statistical Techniques to Derive Reference Intervals


Cytogenetic Studies of Participants of the Fernald Medical Monitoring Program


Computer Modeling of Exposure Plumes and Linkage of Exposure Level Estimates with Geographical Points of Residence. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)


Patterns and Practices of Using a Cistern as a Drinking Water Source to Develop Exposure Metrics. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)


Incident Cancer of the Lung, Female Breast, Prostate, Urinary System and Malignant Melanoma


How 3 Age Groups Perceive the Effect the Program has had on the Overall Health and Well-Being of Their Lives and Their Community.


Effect of Uranium on DNA Replication


Role of Uranium in Mutagenesis of the PDK1 Gene in Autosomal Dominate Polycystic Kidney Disease


Fernald Area Cisterns and Wells:What is Known and What Do We Need to Know?


Incidence of Leukemia and Lymphoma in Participants in the Fernald Medical Monitoring Program. (Add. to The Epidemiological Study of Cancer Incidence in FMMP Participants)


Predictors of Screening Mammography Outcomes


Characteristics of Patients with Colorectal Cancer Among Participants of Fernald Medical Monitoring Program


Perceived Health Status of FMMP Participants Before and One Year Following the Initial Examination.


Genetic Epidemiology of Lung Cancer Consortium (Genotyping of controls)


Effect of Change in Body Weight on Prostatic Specific Antigen Level


Head-and-Neck Cancer and Search for Genetic Polymorphisms (genotyping of cases and controls)


Cellular Markers of Uranium Stress


Association Between Serum Bilirubin and Cancer


Beta-2-microglobulin and Body Mass Index in Residents Living Near a Uranium Plant in Fernald, Ohio


Metabolic Syndrome and Chronic Disease Morbidity and Mortality in the FMMP Population


Natural History of Obesity without Surgical Intervention


In Search of Earlier Diabetic Signs in "Under-Threshold Ranges"


Methods Study of Breast Density Assessment from Digitalization of Old Mammographic Films and that from FMMP Mammorgaphy Codes


Analysis of Urine Albumin and Urinary Beta2 Microglobulin Data


The Association of CD 14 levels with the Development of Abdominal Aortic Aneurysm


The Cancerous Effects of Ingesting Uranium Contaminated Water as a Child


Development of children in the Fernald Medical Monitoring Program (FMMP)


Collection conditions and reference intervals for using Beta-2-microglobulin (B 2M) as a biomarker of renal function


Mammographic breast density as a risk factor for Breast Cancer: Environmental and Genetic Determinants


Oxidative stress and prostate cancer, a prospective analysis


Kidney Function and Damage in Fernald Medical Monitoring Program Participants Exposed to Uranium


The Influence of Perceived Uranium Exposure on Health Perception


Exposure Biomarkers of Polyfluoroalkyl Compounds in Persons Living in the Ohio River Valley


Pre-Existing Maternal Constitutional Factors, The Missing Link Between Adverse Pregnancy Outcomes and Cartiovascular Disease


Reproductive History Data Analysis


Uranium Exposures in a Community near the Fernald, Ohio Weapons Production Facility: Relationship with Hypertension and Hematologic Markers


Investigation of the association between lifetime sun exposure and benign neoplasms of the bowel and other health concerns


Allelic variants and DNA damage response in the Fernald Study Group


A longitudinal analysis of thyroid stimulating hormone levels and weight in the Fernald Medical Monitoring Program (FMMP)


A longitudinal analysis of thyroid stimulating hormone levels and intake of dietary and drinking water nitrate in the Fernald Medical Monitoring Program (FMMP) cohort


Comparison calculated BMI's and Stunkard Figures of self and parents


Spirituality Data


Assessment of Archived blood specimens for nucleic acid quality and quantity


Verification of serum sPLA2-lla as a biomarker for lung cancer


Investigating the Comorbid Medical Illnesses associated with Migraine, Tension type and Other Headached Disorders.


Outline Various Types of Statistical Analyses That Could be Performed and the Required Resources


Clinical Study, M-Vu Mammography CAD Algorithm Engine


VuComp-M-Vu Clinical Study


Placental latogen in breast cancer


Autoimmunity and Rheumatologic Disease in Community Residents Near a Uranium Plant at Fernald


Clinical, Environmental and Genetic Factors related to Variable Response to Oral Anti-Diabetic Medication


Verification of serum sPLA2-lla as a biomarker for prostate cancer


OPNc, a marker for cancer progression


Tobacco Smoke Exposure Health Effects


Secretory Phospholipase A2-llA Levels in Patients with Newly Diagnosed Breast Cancer


Mechanism behind multiparity-induced obesity


Frequency of Diagnoses in the FMMP Database


Hypothyroidism and cancer risk


Uranium Exposure and Autoimmune Thyroid Disease Near the Fernald Processing Plant


Autoimmune disease and /or autoimmune-related biomarkers in a cohort occupationally exposed to Libby Amphibole


Exposure to Radon and Sunlight and the Riskof Melanoma


Probing for Endometriosis Associated Serum Diagnostic Markers in the Fernald Community Cohort


Uranium Exposure and Pregnancy Outcomes in the Fernald cohort


Adult health effects associated with perfluorooctanoic acid (PFOA) exposure


The role of fibrinogen in abdominal aortic aneurysm


Exposure to BPA and Cardiac electrical alterations in the FMMP population


Identifying environmental exposures associated with inflammation and breast density using targeted and non-targeted metabolomics


Incidence and Prevalence of Breast Neoplasm Amoung Women Chronically Exposed to Low-Level Ionizing Radiation


Urine biomarkers for urological diseases


Perfluoroalkyl substance exposure to children living in the Mid-Ohio Valley in 1991-2008, body size and cholesteroal fractions


Project Title

Last Name

Does Exposure to Environmental Radiation Affect the Frequency of a Pregnancy Ending in Fetal Loss, Spontaneous Abortion, Still Birth or Ectopic Pregnancy?


Archived Biospecimens

~~As of September 30, 2016, we have 159,645 banked biospecimens in six -80 C freezers.
Number of 1.0 ml aliquots (in 1.5 ml polypropylene cyrovial) banked per person at different times and total number of aliquots.
Examination/Year Blood Serum Plasma Urine (unbuffered) Urine (buffered)
Initial exam (mostly 1991-1994) 15 15 15 15 15
Second exam  2 2  
2006 (just those with cancer diagnoses) 3    
2007-2008 exam (urine only on a portion of the cohort) 3 3  3 3
Total aliquots remaining in freezer1 (not distributed) 32,990 48,139 36,179 21,017 20,940
1 An additional 380 DNA aliquots are banked in the freezers

Aliquots are stored in six -80 C freezers, with polypropylene boxes stored within metal racks, which improves temperature stability when the freezer is opened. 

1. Copeland BE, Pesce AJ. The Medical Heritage Concept: A Model for Assuring Comparable Laboratory Results in Long-Term Longitudinal Studies. Ann Clin Lab Sci 1992; 22(2):110-124. PMID: 1562165

2. Wones R, Radack K, Martin V, Mandell K, Pinney S, Buncher R. Do persons living near a uranium processing site have cytogenetic damage? Mutation Research 1995; 335:171-184. PMID: 7477048.

3. Radack KL, Pinney SM, Livingston GK. Sources of variability in the human lymphocyte micronucleus assay: A population-based study, Environmental and Molecular Mutagenesis 1995; 26:26-36. PMID: 7641705

4. Radack K, Martin V, Wones R, Buncher R, Pinney S, Mandell K. Intercorrelations and sources of variability in three mutagenicity assays of somatic mutations: A population-based study. Mutation Research 1996; 350:295-306. PMID: 8600359

5. De BK, Karr BA, Ghosn S, Copeland BE. Problems and Practical Considerations in Assessing Accuracy with NIST SRM 909a; Report of Defective Vials. Clinical Chemistry 1996; 42(11):1832-1837. PMID:8906084

6. Woo JG, Pinney SM. Retrospective Smoking History Data Collection for Deceased Workers: Completeness and Accuracy of Surrogate Reports. JOEM 2002; 44(10):915-923. PMID: 12921382

7. Pinney SM, Freyberg RW, Levine GH, Brannen DE, Mark LS, Nasuta JM, Tebbe CD, Buckholz JM, Wones R. Health Effects in Community Residents Near a Uranium Plant at Fernald, Ohio, USA. International Journal of Occupational Medicine and Environmental Health 2003; 16(2):139-153. PMID: 12921382

8. Bailey-Wilson JE*, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson M. A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics 2004; 75:460-474. Epub 2004 Jul 21.PMID: 15272417

9. Gerhardstein BG, Brown P. The Benefits of Community Medical Monitoring at Nuclear Weapons Production Sites: Lessons From Fernald. Environmental Law Review News & Analysis 2005; 35:10531-10538. No PMID

10. Brown MK, Verkamp S, Yocum E, Schrorr C. Fernald Area Cisterns and Wells: What is Known and What Do We Need To Know? The findings of the MTA project are provided in their entirety on CD (publication 2006), in bound Manual (publication 2008) and at the following websites:,

11. Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Jinna J, Gaba C, Rothchild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson W, You M. Identification of a Novel Tumor Suppressor Gene p34 on Human Chromosome 6q25.1. Cancer Research 2007; 67(1): 93-99. PMID: 17210687

12. Vikis H, Sato M, James M, Wang D, Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D, Viswanathan A, Govindan R, Minna J, Anderson MW, You M. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Research 2007; 67(10): 4665-70. PMID: 17510392

13. Hornung RW, Pinney SM, Lodwick J, Killough G, Brewer DE, Nasuta J. Estimation of Radon Exposures to Workers at the Fernald Feed Materials Production Center, 1952-1988. Journal of Exposure Science and Environmental Epidemiology 2008; 18(5):512-523. Epub 2008 Jan 9. PMID: 18183043

14. Liu P, Vikis HG Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Peterson GM, Weist JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee, J, Kupert E, Seminara D, Minna J, Bailey- Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M. Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer. Journal of the National Cancer Institute 2008; 100(18):1326-1330. PMID: 18780872

15. You M*, Wang D*, Liu P*, Vikis H*, James M*, Lu Y, Wang Y, Wang M, Jia D, Liu Y, Yang P, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW . Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clinical Cancer Research 2009; 15(8); 2666-73. Epub 2009 Apr 7. PMID: 19351763

16. Christiani DC. Lung Cancer Genetics: A Family Affair. Clin Cancer Res 2009; 15(8):2581-2582. PMID: 19351746

17. Wones R, Pinney SM, Buckholz JM, Deck-Tebbe C, Freyberg R, Pesce A. Medical Monitoring: A Beneficial Remedy for Residents Living Near an Environmental Hazard Site. J Occup Environ Med. 2009; 51:1374–1383. PMID: 19952785 doi: 10.1097/JOM.0b013e3181c558f1

18. Liu Y, Liu P, Wen W, James MA, Wnag Y, Bailey-Wilson JE, Amos CI, PInney SM, Yang P, de Andrade M, Peterson GM, Wiest JS, Pain PR, Schwartz AG, Gazdar A, Gaba C, Pothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M. Haplotype cell proliferation analyses of candidate lung cancer susceptibility genes on chromosomes 15q24-25.1. Cancer Research 2009; 69(19): 7844-7850. PMID: 1978933

19. Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest J, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW. A susceptibility locus on chromosome 6q greatly increases risk lung cancer risk among light and never smokers. Cancer Research 2010; 70(6):2359-2367. Epub 2010 Mar 9. PMID: 20215501

20. Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M. A Second Genetic Variant on Chromosome 15q24-25.1 Associates with Lung Cancer. Cancer Research 2010; 70(8): 3128-35. PMID: 20395203

21. Fang S, Pinney SM, Bailey-Wilson J, de Andrade M, Li Yafang, Kupert E, You M, Schwartz A, Yang P, Anderson M, Amos CI. Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q. Cancer Epidemiol Biomarkers Prev 2010; 19(12):3157-66. Epub 2010 Oct 28. PMID: 21030603

22. Wagner SE, Burch JB, Bottai M, Puett R, Porter D, Pinney SM, Vena JE, J.R. Hypertension and hematologic parameters in a community near a uranium processing facility. Environmental Research 2010; 110(8):786-797. PMID: 20889151

23. Yaghjyan L, Pinney SM, Mahoney MC, Morton AR, Buckholz J, Samaratunga R. Mammographic Breast Density Assessment: A Methods Study. Atlas Journal of Medical & Biological Sciences 2011; 1(1): 8-14. No PMID

24. Kupert E, Anderson M, Liu Y, Succop P, Levin L, Wang J, Wikenheiser-brokamp K, Chen P, Pinney SM, Macdonald T, Dong Z, Starnes S, Lu S. Plasma secretory phospholipase A2-lll as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BCM Cancer 2011; 11:513. PMID: 22151235

25. Yaghjyan L, Mahoney MC, Succop P, Wones R, Buckholz J, Pinney SM. Relationship between breast cancer risk factors and mammographic breast density in Fernald Community Cohort. British Journal of Cancer 2012; 106(5): 996-1003. Epub 2012 Jan 26. PMID: 22281662

26. Blomkalns AL, Gavrila D, Thomas M, Nelter BS, Blanco VM, Benjamin SB, McCormick ML, Stoll LL, Denning GM, Collins SP, Qin Z, Daugherty A, Cassis LA, Thompson RW, Weiss RM, Linkower PD, Pinney SM, Chatterjee T, Weintraub NL. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc 2013; 8(2):2. PMID: 23537804

27. Lu PY, Kottyan LC, James JA, Xie C, Buckholz JM, Pinney SM, Harley JB. Systemic Lupus Erythematosus is Associated with Uranium Exposure in a Community Living Near a Uranium Processing Plant: A Nested Case-Control Study. Arthritis and Rheumatology 2014; 66(11):3105-3112. PMID: 25103365;jsessionid=ADA04BD338DC7990D56CBD8DB52A513C.f04t04

28. Xiong D, Wang Y, Kupert E, Simpson C, Pinney SM, Gaba CR, Mandal D, Schwartz AG, Yang P, de Andrade M, Pikielny C, Byun J, Li Y, Stambolian D, Spitz MR, Amos CI, Bailey-Wilson JE, Anderson MW, You M. A recurrent mutation in PARK2 in familial lung cancer. Am J Hum Genet 2015; 96(2):301-308. Epub 2015 Jan 29. PMID:25640678

29. Yang S, Pinney SM, Mallick P, Ho SM, Bracken B, Wu T. Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study. Clin Genitourin Cancer. 2015 Apr 18. pii: S1558-7673(15)00076-2. doi: 10.1016/j.clgc.2015.04.004. [Epub ahead of print]. PMID:25972296.

30. Xie, C., Ghulam, E., Chen, A., Wang, K., Pinney, S., & Lindsell, C. (2015). Weighted Multiple Testing Correction for Correlated Endpoints in Survival Data. In D. Chen, J. Wilson (Eds), Innovative Statistical Methods for Public Health Data (pp315-323) Switzerland: Springer International Publishing.

31. Pinney SM, Biro FM. Letter to the editor re Morollo-Frosh “Communicating Results in Post-Belmont Era Biomonitoring Studies”. Environ Res. 2015; June 12. [Epub ahead of print]. 26076818.

32. Liu Y, Kheradmand F, Davi CF1, Scheurer ME, Wheeler D, Tsavachidis S, Armstrong G, Simpson C, Mandal D, Kupert E, Anderson M, You M, Xiong D, Pikielny C, Schwartz AG, Bailey-Wilson JE, Gaba C, De Andrade M, Yang P, Pinney SM, The Genetic Epidemiology of Lung Cancer Consortium, Amos CI, Spitz MR. Focused Analysis of Exome Sequencing Data for Rare Mutations in Familial and Sporadic Lung Cancer. In press, Journal of Thoracic Oncology. 2016 Jan;11(1):52-61. doi: 10.1016/j.jtho.2015.09.015.

33. Jorge-Nebert LF, Zhang G, Wilson KM, Jiang Z, Butler R, Gluckman JL, Pinney SM, Nebert DW. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype. Hum Genomics 2016; 10(1): 39.

34. Martin AT, Pinney SM, Xie C, Herrick RL, Bai Y, Buckholz J, Martin VT. Headache Disorders are a Risk Factor for the Development of New Onset Hypothyroidism. Headache 2017; 57:21-30. doi: 10.1111/head.12943. Epub 2016 Sep 27. PMID: 27676320.

35. Herrick RL, Buckholz JM, Biro FM, Calafat AM, Ye X, Xie C, Pinney SM. Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012. Environmental Pollution 2017; 228: 50-60.

36. Giannini CM, Herrick RL, Buckholz JM, Daniels AR, Biro FM, Pinney SM. Comprehension and Perceptions of Study Participants Upon Receiving Perfluoroalkyl Substance Exposure Biomarker Results. Submitted to the International Journal of Hygiene and Environmental Health, March 12th, 2018.



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