A Life in Medicine is a course for anyone considering medicine as a career. It is also necessary for everyone who consider medicine to be their life's calling. The course will include a series of presentations, open discussions and illustrations of medicine's foundation, its evolution and the major influences on medicine as we recognize it today. The course is divided into three sections: Section I is focused on the origins of medicine, specifically the lives and teachings of the "Founding Fathers". Section II carefully examines the evolution of medicine from the 18th through the 20th century and its enlightenment periods, ranging from the study of anatomy and physiology to the "white coat" era and application of science to the understanding of disease and the development of treatment. It also carefully examines the application of research, dark periods in human subjects in research and the foundation of regulatory bodies to protect the public. Section III is dedicated to the translation of medicine's fundamental principles and foundation to current, modern- day paradigms, including global health, health care systems, affordable care, and medical school curriculums.