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Department of

Otolaryngology-Head and Neck Surgery

Photo of  John Greinwald, MD

John Greinwald, MD

Director, Genetics of Division of Pediatric Otolaryngology

Education/Credentials
  • Medical Degree: University of South Carolina

Contact Information

Peer Reviewed Publications

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Johnson, Kaalan; Tabangin, Meredith; Meinzen-Derr, Jareen; Cohen, Aliza P; Greinwald, John H 2015. High-frequency sensorineural hearing loss in children. The Laryngoscope, ,

Nayak, Gowri; Varga, Lukas; Trincot, Claire; Shahzad, Mohsin; Friedman, Penelope L; Klimes, Iwar; Greinwald, John H; Riazuddin, S Amer; Masindova, Ivica; Profant, Milan; Khan, Shaheen N; Friedman, Thomas B; Ahmed, Zubair M; Gasperikova, Daniela; Riazuddin, Sheikh; Riazuddin, Saima 2015. Molecular genetics of MARVELD2 and clinical phenotype in Pakistani and Slovak families segregating DFNB49 hearing loss. Human genetics, 134 4, 423-37

Prosser, John Drew; Cohen, Aliza P; Greinwald, John H 2015. Diagnostic Evaluation of Children with Sensorineural Hearing Loss. Otolaryngologic clinics of North America, 48 6, 975-82

Prows, Cynthia A; Zhang, Xue; Huth, Myra M; Zhang, Kejian; Saldaña, Shannon N; Daraiseh, Nancy M; Esslinger, Hope R; Freeman, Edita; Greinwald, John H; Martin, Lisa J; Sadhasivam, Senthilkumar 2014. Codeine-related adverse drug reactions in children following tonsillectomy: a prospective study. The Laryngoscope, 124 5, 1242-50

Shahzad, Mohsin; Sivakumaran, Theru A; Qaiser, Tanveer A; Schultz, Julie M; Hussain, Zawar; Flanagan, Megan; Bhinder, Munir A; Kissell, Diane; Greinwald, John H; Khan, Shaheen N; Friedman, Thomas B; Zhang, Kejian; Riazuddin, Saima; Riazuddin, Sheikh; Ahmed, Zubair M 2013. Genetic analysis through OtoSeq of Pakistani families segregating prelingual hearing loss. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 149 3, 478-87

Sivakumaran, Theru A; Husami, Ammar; Kissell, Diane; Zhang, Wenying; Keddache, Mehdi; Black, Angela P; Tinkle, Brad T; Greinwald, John H; Zhang, Kejian 2013. Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 148 6, 1007-16

Prager, Jeremy D; Neidich, Marci J; Perkins, Jonathan N; Meinzen-Derr, Jareen; Greinwald, John H 2012. Minimal access and standard cochlear implantation: a comparative study. International journal of pediatric otorhinolaryngology, 76 8, 1102-6

Sun, Gordon H; Harmych, Brian M; Dickson, J Matthew; Gonzalez del Rey, Javier A; Myer, Charles M; Greinwald, John H 2011. Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding. Archives of otolaryngology--head & neck surgery, 137 1, 65-8

Hopkins, Brandon S; Johnson, Kaalan E; Ksiazek, Jeff M; Sun, Gordon; Greinwald, John H; Rutter, Michael 2010. H1N1 influenza A presenting as bacterial tracheitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 142 4, 612-4

Johnson, Romaine F; Cohen, Aliza P; Guo, Yingshi; Schibler, Kurt; Greinwald, John H 2010. Genetic mutations and aminoglycoside-induced ototoxicity in neonates. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 142 5, 704-7

Kothiyal, Prachi; Cox, Stephanie; Ebert, Jonathan; Husami, Ammar; Kenna, Margaret A; Greinwald, John H; Aronow, Bruce J; Rehm, Heidi L 2010. High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays. BMC biotechnology, 10 , 10

Propst, Evan J; Greinwald, John H; Schmithorst, Vincent 2010. Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging. Archives of otolaryngology--head & neck surgery, 136 1, 22-6

Bardien, Soraya; Human, Hannique; Harris, Tashneem; Hefke, Gwynneth; Veikondis, Rene; Schaaf, H Simon; van der Merwe, Lize; Greinwald, John H; Fagan, Johan; de Jong, Greetje 2009. A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness. BMC medical genetics, 10 , 2

Kothiyal, Prachi; Cox, Stephanie; Ebert, Jonathan; Aronow, Bruce J; Greinwald, John H; Rehm, Heidi L 2009. An overview of custom array sequencing. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.], Chapter 7 , Unit 7.17

Lee, Kenneth H; Larson, Daniel A; Shott, Gordon; Rasmussen, Brian; Cohen, Aliza P; Benton, Corning; Halsted, Mark; Choo, Daniel; Meinzen-Derr, Jareen; Greinwald, John H 2009. Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations. The Laryngoscope, 119 3, 554-8

Saunders, James E; Greinwald, John H; Vaz, Sharon; Guo, Yinshi 2009. Aminoglycoside ototoxicity in Nicaraguan children: patient risk factors and mitochondrial DNA results. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 140 1, 103-7

Chen, Jianfu; Yang, Li; Yang, Aifen; Zhu, Yi; Zhao, Jianyue; Sun, Dongmei; Tao, Zhihua; Tang, Xiaowen; Wang, Jindan; Wang, Xinjian; Tsushima, Asami; Lan, Jinshan; Li, Weixing; Wu, Fangli; Yuan, Qian; Ji, Jingzhang; Feng, Jinbao; Wu, Chunli; Liao, Zhisu; Li, Zhiyuan; Greinwald, John H; Lu, Jianxin; Guan, Min-Xin 2007. Maternally inherited aminoglycoside-induced and nonsyndromic hearing loss is associated with the 12S rRNA C1494T mutation in three Han Chinese pedigrees. Gene, 401 1-2, 4-11

Putcha, Girish V; Bejjani, Bassem A; Bleoo, Stacey; Booker, Jessica K; Carey, John C; Carson, Nancy; Das, Soma; Dempsey, Melissa A; Gastier-Foster, Julie M; Greinwald, John H; Hoffmann, Marcy L; Jeng, Linda Jo Bone; Kenna, Margaret A; Khababa, Ishrag; Lilley, Margaret; Mao, Rong; Muralidharan, Kasinathan; Otani, Iris M; Rehm, Heidi L; Schaefer, Fred; Seltzer, William K; Spector, Elaine B; Springer, Michelle A; Weck, Karen E; Wenstrup, Richard J; Withrow, Stacey; Wu, Bai-Lin; Zariwala, Maimoona A; Schrijver, Iris 2007. A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort. Genetics in medicine : official journal of the American College of Medical Genetics, 9 7, 413-26

Saunders, James E; Vaz, Sharon; Greinwald, John H; Lai, James; Morin, Leonor; Mojica, Karen 2007. Prevalence and etiology of hearing loss in rural Nicaraguan children. The Laryngoscope, 117 3, 387-98

Schraff, Scott A; Brown, David K; Schleiss, Mark R; Meinzen-Derr, Jareen; Greinwald, John H; Choo, Daniel I 2007. The role of CMV inflammatory genes in hearing loss. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 28 7, 964-9

Schraff, Scott A; Schleiss, Mark R; Brown, David K; Meinzen-Derr, Jareen; Choi, K Yeon; Greinwald, John H; Choo, Daniel I 2007. Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 137 4, 612-8

Preciado, Diego A; Lawson, Louise; Madden, Colm; Myer, David; Ngo, Chris; Bradshaw, John K; Choo, Daniel I; Greinwald, John H 2005. Improved diagnostic effectiveness with a sequential diagnostic paradigm in idiopathic pediatric sensorineural hearing loss. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 26 4, 610-5

Wang, Qiuju; Li, Roughua; Zhao, Hui; Peters, Jennifer L; Liu, Qiong; Yang, Li; Han, Dongyi; Greinwald, John H; Young, Wie-Yen; Guan, Min-Xin 2005. Clinical and molecular characterization of a Chinese patient with auditory neuropathy associated with mitochondrial 12S rRNA T1095C mutation. American journal of medical genetics. Part A, 133A 1, 27-30

Young, Wie-Yen; Zhao, Lidong; Qian, Yaping; Wang, Qiuju; Li, Ning; Greinwald, John H; Guan, Min-Xin 2005. Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation. Biochemical and biophysical research communications, 328 4, 1244-51

Yuan, Huijun; Qian, Yaping; Xu, Yanjun; Cao, Juyang; Bai, Linna; Shen, Weidong; Ji, Fei; Zhang, Xin; Kang, Dongyang; Mo, Jun Qin; Greinwald, John H; Han, Dongyi; Zhai, Suoqiang; Young, Wie-Yen; Guan, Min-Xin 2005. Cosegregation of the G7444A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes with the 12S rRNA A1555G mutation in a Chinese family with aminoglycoside-induced and nonsyndromic hearing loss. American journal of medical genetics. Part A, 138A 2, 133-40

Chadwell, Jon B; Halsted, Mark J; Choo, Daniel I; Greinwald, John H; Benton, Corning 2004. The cochlear cleft. AJNR. American journal of neuroradiology, 25 1, 21-4

Dou, Hongwei; Xu, Jie; Wang, Zhaohui; Smith, Annabel N; Soleimani, Manoocher; Karet, Fiona E; Greinwald, John H; Choo, Daniel 2004. Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 52 10, 1377-84

Guo, Yingshi; Pilipenko, Valentina; Lim, Lynne H Y; Dou, Hongwei; Johnson, Liane; Srisailapathy, C R Srikumari; Ramesh, Arabandi; Choo, Daniel I; Smith, Richard J H; Greinwald, John H 2004. Refining the DFNB17 interval in consanguineous Indian families. Molecular biology reports, 31 2, 97-105

Li, R; Greinwald, J H; Yang, L; Choo, D I; Wenstrup, R J; Guan, M-X 2004. Molecular analysis of the mitochondrial 12S rRNA and tRNASer(UCN) genes in paediatric subjects with non-syndromic hearing loss. Journal of medical genetics, 41 8, 615-20

Pilipenko, Valentina V; Reece, Alisa; Choo, Daniel I; Greinwald, John H 2004. Genomic organization and expression analysis of the murine Fam3c gene. Gene, 335 , 159-68

Preciado, Diego A; Lim, Lynne H Y; Cohen, Aliza P; Madden, Colm; Myer, David; Ngo, Chris; Bradshaw, John K; Lawson, Louise; Choo, Daniel I; Greinwald, John H 2004. A diagnostic paradigm for childhood idiopathic sensorineural hearing loss. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 131 6, 804-9

Salamone, Frank N; Bobbitt, D Bradley; Myer, Charles M; Rutter, Michael J; Greinwald, John H 2004. Bacterial tracheitis reexamined: is there a less severe manifestation? Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 131 6, 871-6

Lim, Lynne H Y; Bradshaw, John K; Guo, Yingshi; Pilipenko, Valentina; Madden, Colm; Ingala, David; Keddache, Mehdi; Choo, Daniel I; Wenstrup, Richard; Greinwald, John H 2003. Genotypic and phenotypic correlations of DFNB1-related hearing impairment in the Midwestern United States. Archives of otolaryngology--head & neck surgery, 129 8, 836-40

Madden, Colm; Halsted, Mark J; Hopkin, Robert J; Choo, Daniel I; Benton, Corning; Greinwald, John H 2003. Temporal bone abnormalities associated with hearing loss in Waardenburg syndrome. The Laryngoscope, 113 11, 2035-41

Merves, Michele; Krane, Carissa M; Dou, Hongwei; Greinwald, John H; Menon, Anil G; Choo, Daniel 2003. Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant. Journal of the Association for Research in Otolaryngology : JARO, 4 2, 264-75

Giguère, Chantal M; Bauman, Nancy M; Sato, Yutaka; Burke, Diane K; Greinwald, John H; Pransky, Seth; Kelley, Peggy; Georgeson, Keith; Smith, Richard J H 2002. Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Archives of otolaryngology--head & neck surgery, 128 10, 1137-44

Greinwald, John H; Hartnick, Christopher J 2002. The evaluation of children with sensorineural hearing loss. Archives of otolaryngology--head & neck surgery, 128 1, 84-7

Madden, Colm; Rutter, Michael; Hilbert, Lisa; Greinwald, John H; Choo, Daniel I 2002. Clinical and audiological features in auditory neuropathy. Archives of otolaryngology--head & neck surgery, 128 9, 1026-30

Scott, Kirby J; Schroeder, Ashley A; Greinwald, John H 2002. Ectopic cervical thymus: an uncommon diagnosis in the evaluation of pediatric neck masses. Archives of otolaryngology--head & neck surgery, 128 6, 714-7

Carron, J D; Greinwald, J H; Oberman, J P; Werner, A L; Derkay, C S 2001. Simulated reflux and laryngotracheal reconstruction: a rabbit model. Archives of otolaryngology--head & neck surgery, 127 5, 576-80

Gessler, E M; Hart, A K; Dunlevy, T M; Greinwald, J H 2001. Optimal concentration of epinephrine for vasoconstriction in ear surgery. The Laryngoscope, 111 10, 1687-90

Holcomb, J D; Jaffe, D M; Greinwald, J H; Bauman, N M; Smith, R J 2001. Nontraumatic atlantoaxial rotary subluxation in the pediatric otolaryngology patient. A report of four cases. The Annals of otology, rhinology, and laryngology, 110 12, 1137-40

Scott, K J; Greinwald, J H; Darrow, D; Smith, R J 2001. Endobronchial tumors in children: an uncommon clinical entity. The Annals of otology, rhinology, and laryngology, 110 1, 63-9

Lim, A A; Washington, A P; Greinwald, J H; Lassen, L F; Holtel, M R 2000. Effect of pentoxifylline on the healing of guinea pig tympanic membrane. The Annals of otology, rhinology, and laryngology, 109 3, 262-6

Greinwald, J H; Bauman, N M 1999. Larsen's syndrome. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 121 6, 845

Greinwald, J H; Burke, D K; Bonthius, D J; Bauman, N M; Smith, R J 1999. An update on the treatment of hemangiomas in children with interferon alfa-2a. Archives of otolaryngology--head & neck surgery, 125 1, 21-7

Greinwald, J H; Burke, D K; Sato, Y; Poust, R I; Kimura, K; Bauman, N M; Smith, R J 1999. Treatment of lymphangiomas in children: an update of Picibanil (OK-432) sclerotherapy. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 121 4, 381-7

Lim, A A; Wall, M P; Greinwald, J H 1999. Effects of dimethylthiourea, melatonin, and hyperbaric oxygen therapy on the survival of reimplanted rabbit auricular composite grafts. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 121 3, 231-7

Olney, D R; Greinwald, J H; Smith, R J; Bauman, N M 1999. Laryngomalacia and its treatment. The Laryngoscope, 109 11, 1770-5

Chen, A H; Mueller, R F; Prasad, S D; Greinwald, J H; Manaligod, J; Muilenburg, A C; Verhoeven, K; Van Camp, G; Smith, R J 1998. Presymptomatic diagnosis of nonsyndromic hearing loss by genotyping. Archives of otolaryngology--head & neck surgery, 124 1, 20-4

Greinwald, J H; Simko, E J 1998. Diagnosis and management of middle ear osteomas: a case report and literature review. Ear, nose, & throat journal, 77 2, 134-6, 138-9

Greinwald, J H; Wayne, S; Chen, A H; Scott, D A; Zbar, R I; Kraft, M L; Prasad, S; Ramesh, A; Coucke, P; Srisailapathy, C R; Lovett, M; Van Camp, G; Smith, R J 1998. Localization of a novel gene for nonsyndromic hearing loss (DFNB17) to chromosome region 7q31. American journal of medical genetics, 78 2, 107-13

Hart, A K; Greinwald, J H; Shaffrey, C I; Postma, G N 1998. Thoracic duct injury during anterior cervical discectomy: a rare complication. Case report. Journal of neurosurgery, 88 1, 151-4

Scott, D A; Greinwald, J H; Marietta, J R; Drury, S; Swiderski, R E; Viñas, A; DeAngelis, M M; Carmi, R; Ramesh, A; Kraft, M L; Elbedour, K; Skworak, A B; Friedman, R A; Srikumari Srisailapathy, C R; Verhoeven, K; Van Gamp, G; Lovett, M; Deininger, P L; Batzer, M A; Morton, C C; Keats, B J; Smith, R J; Sheffield, V C 1998. Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene, 215 2, 461-9

Dunlevy, T M; Washington, A P; Greinwald, J H 1997. Pathologic quiz case 2. Congenital cartilaginous rests of the neck (CCRNs) (wattles). Archives of otolaryngology--head & neck surgery, 123 6, 655, 657

Gnuechtel, M M; Keyser, J S; Greinwald, J H; Postma, G N 1997. Electrocautery versus carbon dioxide laser for uvulopalatoplasty in the treatment of snoring. The Laryngoscope, 107 7, 848-54

Greinwald, J H; Lassen, L F 1997. Lipomas of the internal auditory canal. The Laryngoscope, 107 3, 364-8

Greinwald, J H; Scott, D A; Marietta, J R; Carmi, R; Manaligod, J; Ramesh, A; Zbar, R I; Kraft, M L; Elbedour, K; Yairi, Y; Musy, M; Skvorak, A B; Van Camp, G; Srisailapathy, C R; Lovett, M; Morton, C C; Sheffield, V C; Smith, R J 1997. Construction of P1-derived artificial chromosome and yeast artificial chromosome contigs encompassing the DFNB7 and DFNB11 region of chromosome 9q13-21. Genome research, 7 9, 879-86

Greinwald, J H; Holtel, M R 1996. Absorption of topical cocaine in rhinologic procedures. The Laryngoscope, 106 10, 1223-5

Greinwald, J H; Leichtman, L G; Simko, E J 1996. Hereditary thyroglossal duct cysts. Archives of otolaryngology--head & neck surgery, 122 10, 1094-6

Greinwald, J H; Wilson, J F; Haggerty, P G 1995. Peritonsillar abscess: an unlikely cause of necrotizing fasciitis. The Annals of otology, rhinology, and laryngology, 104 2, 133-7

Gessler, Eric M; Simko, Eric J; Greinwald, John H . Adult laryngomalacia: an uncommon clinical entity. American journal of otolaryngology, 23 6, 386-9

Van Laer, L; Van Camp, G; van Zuijlen, D; Green, E D; Verstreken, M; Schatteman, I; Van de Heyning, P; Balemans, W; Coucke, P; Greinwald, J H; Smith, R J; Huizing, E; Willems, P . Refined mapping of a gene for autosomal dominant progressive sensorineural hearing loss (DFNA5) to a 2-cM region, and exclusion of a candidate gene that is expressed in the cochlea. European journal of human genetics : EJHG, 5 6, 397-405