Coronavirus COVID-19 Updates: uc.edu/publichealth
Our previous work has set the standard for what types of evaluations should be performed on children with hearing loss to determine the etiology. We are currently evaluating the effects of unilateral enlarged vestibular aqueduct and studying the
natural history of unilateral sensorineural hearing loss. We have just completed studies defining the risks of progression and asymmetry in patients with and without GJB2-related hearing loss.
As part of a long standing interdisciplinary effort, we are developing the first resequencing microarray to evaluate for genetic causes of deafness in young children with hearing loss. These advances will allow us to more accurately predict the
clinical course of the child, appropriate treatment and secondary medical diagnoses.
Our center enrolls families interested in studies to determine the genetic cause of their hearing loss. Besides the US, families from India, Bangladesh and Singapore have been studied here. These studies help to identify novel genes the gives
scientists new in roads to the understanding of hearing.
We are studying the affects of early treatment on the clinical course of young children with hearing loss. Early identification and treatment is thought to be critical to the success of children with hearing loss, but the initial language, education
and socially-based strategies to utilize on these children is ill defined. Our research should point early intervention specialists toward more effective therapy options.
Mitochondrial mutations play a significant role in the development of hearing loss in children, both nonsyndromic and in association with the administration of aminoglcyoside antibiotics. We have studied the molecular mechanisms of mitochondrial
mutation in cell, animal and human models.
Our Center is one of the largest research imaging groups dedicated to childhood diseases. fMRI allows our researchers to examine the direct effect of sound and the lack of sound on the brain pathways and processing. These findings are leading
our researchers to better predict which children would be best served with a cochlear implant to restore hearing.
With at least half of all causes of congenital hearing loss due to genetic or hereditary factors, it is very relevant to study the genes involved in normal development of the inner ear as well as the consequences to the ear and hearing when critical genes
By identifying the key genetic processes involved in forming a normal inner ear, we begin to understand the possibilities of either correcting mal-development of the inner ear or potentially finding novel ways to correct defects of the ear and deafness.
Of all the cases of pediatric sensorineural hearing loss in the United States, a significant portion of the cases are due to inner ear infections caused by CMV. However, the ability to detect this infection clinically and our understanding of how the
virus causes inner ear damage and hearing loss is limited.
Research is ongoing now to screen several thousand newborns for this congenital infection and to determine the natural history of hearing loss in these children. Concurrent research is directed at examining the potential benefits of delivering antiviral
drugs directly to the inner ear and thereby avoiding the major side effects of using those antivirals when administered systemically.
Medical Sciences Building Room 6507231 Albert Sabin WayCincinnati, OH 45267-0528
Phone: 513-558-4152Fax: 513-558-3231