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Photo of  Mary Beth Genter, PhD

Mary Beth Genter, PhD


Environmental & Public Health Sciences | College of Medicine

  • Postdoctoral Fellowship: Chemical Institute of Toxicology,
  • Doctoral Degree: Duke University (Pathology, toxicology)
  • Bachelor's Degree: St. Lawrence University (chemistry, biology)
Contact Information
Research Interests

The Genter lab studies the olfactory from a number of perspectives, including:

  1. as a site of toxicant-induced damage
  2. as a model for neurogenesis; and, most recently, 
  3. as a route of drug delivery.
Current projects include intranasal administration of two different drugs, namely nilotinib and carnosine, as potential means to slow or stop the progression of symptoms in a mouse model of Parkinson's disease.

Peer Reviewed Publications

Hsieh H, Horwath M, Genter MB 2017. Zinc gluconate toxicity in wild-type vs. MT1/2-deficient mice. NeuroToxicology, 58 , 130-36

Hsieh H, Vignesh KS, Deepe GS Jr, Choubey D, Shertzer HG, Genter MB 2016. Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora. Toxicol In Vitro , 35 , 24-30

Miller DL, Yu IL, Genter MB 2016. Use of autometallography in studies of nanosilver distribution and toxicity. Int J Toxicol. , 35 1, 47-51

Davenport LL, Hsieh H, Eppert BL, Carriera VS, Krishan M, Ingle T, Howard PC, Williams MT, Vorhees CV, Genter MB 2015. Systemic and behavioral effects of intranasal administration of silver nanoparticles. Neurotoxicol Teratol. , 51 , 68-76

Hsieh H, Amlal H, Genter MB 2015. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell Line, Odora Hum Exp Toxicol , 34 3, 308-14

Genter, Mary Beth 2014. Editor's Note. International journal of toxicology, 33 4, 267

Hsieh, H; Amlal, H; Genter, Mb 2014. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora. Human & experimental toxicology, ,

Krishan M, Gudelsky GA, Desai PB, Genter MB. 2014. Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain. Drug Deliv , 21 1, 8-16

Dong, Hongbin; Shertzer, Howard G; Genter, Mary Beth; Gonzalez, Frank J; Vasiliou, Vasilis; Jefcoate, Colin; Nebert, Daniel W 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and biophysical research communications, 435 4, 727-32

Sasso, Alan F; Schlosser, Paul M; Kedderis, Gregory L; Genter, Mary Beth; Snawder, John E; Li, Zheng; Rieth, Susan; Lipscomb, John C 2013. Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice. Toxicological sciences : an official journal of the Society of Toxicology, 131 2, 360-74

Shertzer, Howard G; Krishan, Mansi; Genter, Mary Beth 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neuroscience letters, 548 , 159-64

Barchowsky, Aaron; Buckley, Lorrene A; Carlson, Gary P; Fitsanakis, Vanessa A; Ford, Sue M; Genter, Mary Beth; Germolec, Dori R; Leavens, Teresa L; Lehman-McKeeman, Lois D; Safe, Stephen H; Sulentic, Courtney E W; Eidemiller, Betty J 2012. The Toxicology Education Summit: building the future of toxicology through education. Toxicological sciences : an official journal of the Society of Toxicology, 127 2, 331-8

Curran, Christine P; Vorhees, Charles V; Williams, Michael T; Genter, Mary Beth; Miller, Marian L; Nebert, Daniel W 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological sciences : an official journal of the Society of Toxicology, 119 1, 189-208

Genter, Mary Beth 2011. Editor's Note. International journal of toxicology, 30 4, 383

Shertzer, Howard G; Woods, Sally E; Krishan, Mansi; Genter, Mary Beth; Pearson, Kevin J 2011. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. The Journal of nutrition, 141 4, 582-7

Genter, Mary Beth; Krishan, Mansi; Augustine, Lisa M; Cherrington, Nathan J 2010. Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. Drug metabolism and disposition: the biological fate of chemicals, 38 10, 1644-7

Hopf, Nancy Brenna; Kirkeleit, Jorunn; Kramer, Stacy L; Moen, Bente; Succop, Paul; Genter, Mary Beth; Carreón, Tania; Mack, James; Talaska, Glenn 2010. Urinary 1-hydroxypyrene levels in offshore workers. International archives of occupational and environmental health, 83 1, 55-9

Genter, M B; Warner, B M; Medvedovic, M; Sartor, M A 2009. Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47 6, 1051-7

Genter, Mary Beth; Kendig, Eric L; Knutson, Mitchell D 2009. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Annals of the New York Academy of Sciences, 1170 , 623-8

Shertzer, Howard G; Schneider, Scott N; Kendig, Eric L; Clegg, Deborah J; D'Alessio, David A; Johansson, Elisabet; Genter, Mary Beth 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chemico-biological interactions, 177 1, 71-80

Kendig, Eric L; Schneider, Scott N; Clegg, Deborah J; Genter, Mary Beth; Shertzer, Howard G 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical pharmacology, 76 2, 216-24

Shertzer, Howard G; Genter, Mary B; Talaska, Glenn; Curran, Christine P; Nebert, Daniel W; Dalton, Timothy P 2007. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28 6, 1371-8

Genter, Mary Beth; Clay, Corey D; Dalton, Timothy P; Dong, Hongbin; Nebert, Daniel W; Shertzer, Howard G 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and biophysical research communications, 342 4, 1375-81

Genter, Mary Beth; Marlowe, Jennifer; Kevin Kerzee, J; Dragin, Nadine; Puga, Alvaro; Dalton, Timothy P; Nebert, Daniel W 2006. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and biophysical research communications, 348 1, 120-3

Shertzer, Howard G; Genter, Mary Beth; Shen, Dongxiao; Nebert, Daniel W; Chen, Ying; Dalton, Timothy P 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone. Toxicology and applied pharmacology, 217 3, 363-74

Genter, Mary Beth; Warner, Blake M; Krell, Hans-Willi; Bolon, Brad 2005. Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653. Toxicologic pathology, 33 5, 593-9

Genter, Mary Beth 2004. Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities. Journal of biochemical and molecular toxicology, 18 4, 239-44

Ling, Guoyu; Gu, Jun; Genter, Mary Beth; Zhuo, Xiaoliang; Ding, Xinxin 2004. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-biological interactions, 147 3, 247-58

Shertzer, Howard G; Clay, Corey D; Genter, Mary Beth; Chames, Mark C; Schneider, Scott N; Oakley, Greg G; Nebert, Daniel W; Dalton, Timothy P 2004. Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free radical biology & medicine, 36 5, 618-31

Zhang, Jianhua; Moseley, Amy; Jegga, Anil G; Gupta, Ashima; Witte, David P; Sartor, Maureen; Medvedovic, Mario; Williams, Sarah S; Ley-Ebert, Cathy; Coolen, Lique M; Egnaczyk, Gregory; Genter, Mary Beth; Lehman, Michael; Lingrel, Jerry; Maggio, John; Parysek, Linda; Walsh, Ryan; Xu, Ming; Aronow, Bruce J 2004. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiological genomics, 18 2, 167-83

Genter, Mary Beth; Apparaju, Sandhya; Desai, Pankaj B 2002. Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of biochemical and molecular toxicology, 16 3, 128-34

Genter, Mary Beth; Burman, Dawn M; Vijayakumar, Soundarapandian; Ebert, Cathy L; Aronow, Bruce J 2002. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiological genomics, 12 1, 35-45

Senft, Albert P; Dalton, Timothy P; Nebert, Daniel W; Genter, Mary Beth; Puga, Alvaro; Hutchinson, Richard J; Kerzee, J Kevin; Uno, Shigeyuki; Shertzer, Howard G 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free radical biology & medicine, 33 9, 1268-78

Uno, S; Dalton, T P; Shertzer, H G; Genter, M B; Warshawsky, D; Talaska, G; Nebert, D W 2001. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochemical and biophysical research communications, 289 5, 1049-56

Dalton, T P; Dieter, M Z; Matlib, R S; Childs, N L; Shertzer, H G; Genter, M B; Nebert, D W 2000. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochemical and biophysical research communications, 267 1, 184-9

Wetmore, B A; Mitchell, A D; Meyer, S A; Genter, M B 1999. Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicological sciences : an official journal of the Society of Toxicology, 49 2, 202-12

Genter, M B; Liang, H C; Gu, J; Ding, X; Negishi, M; McKinnon, R A; Nebert, D W 1998. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Biochemical pharmacology, 55 11, 1819-26

Gu, J; Zhang, Q Y; Genter, M B; Lipinskas, T W; Negishi, M; Nebert, D W; Ding, X 1998. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. The Journal of pharmacology and experimental therapeutics, 285 3, 1287-95

Millhorn, D E; Conforti, L; Beitner-Johnson, D; Zhu, W; Raymond, R; Filisko, T; Kobayashi, S; Peng, M; Genter, M B 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. Advances in experimental medicine and biology, 410 , 135-42

Genter, M B; Owens, D M; Deamer, N J 1995. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chemical senses, 20 4, 385-92

Deamer, N J; O'Callaghan, J P; Genter, M B 1994. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Neurotoxicology, 15 2, 287-93

Genter, M B; Deamer, N J; Cao, Y; Levi, P E 1994. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Journal of biochemical toxicology, 9 1, 31-9

Genter, M B; Recio, L 1994. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology, 22 3, 469-73

Genter, M B; Szakál-Quin, G; Anderson, C W; Anthony, D C; Graham, D G 1987. Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. Toxicology and applied pharmacology, 87 2, 351-62

Rosenberg, C K; Genter, M B; Szakál-Quin, G; Anthony, D C; Graham, D G 1987. dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. Toxicology and applied pharmacology, 87 2, 363-73

Crofton, K M; Zhao, X; Sayre, L M; Genter, M B . Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and teratology, 18 3, 297-303

Deshpande, V S; Genter, M B; Jung, C; Desai, P B . Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery. European journal of drug metabolism and pharmacokinetics, 24 2, 177-82

Genter, M B; Deamer, N J; Blake, B L; Wesley, D S; Levi, P E . Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicologic pathology, 23 4, 477-86

Genter, Mary Beth . I am amazed at how time flies, and that we are now reading the fifth issue of International Journal of Toxicology for 2009! International journal of toxicology, 28 5, 339-40

Genter, Mary Beth; Goss, Kathleen H; Groden, Joanna . Strain-specific of alachlor on murine olfactory mucosal responses. Toxicologic pathology, 32 6, 719-25

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