MSTP Faculty
Looking for faculty who share your research interests? See the Research Directory.
| Name | Research Bio | Contact |
|---|---|---|
| Alenghat, Theresa | Epithelial and immune cell homeostasis in the context of intestinal health and disease. The goals of the lab are to provide insight into molecular mechanisms, including epigenomic pathways, that mediate the host-microbiota relationship. | Theresa.Alenghat@cchmc.org Website |
| Araki, Koichi | Understanding of T cell memory and exhaustion | Koichi.Araki@cchmc.org Website |
| Askew, David | Understand the contribution of endoplasmic reticulum stress responses to the virulence and antifungal drug susceptibility of the pathogenic mold Aspergillus fumigatus. | askewds@ucmail.uc.edu Website |
| Baccei, Mark | Neurobiological mechanisms underlying pediatric pain; Maturation of nociceptive circuits in the CNS under normal and pathological conditions. | |
| Barski, Artem | Epigenomics with a focus on the mechanisms of epigenetic regulation involved in T helper cell activation, tolerance and memory. User-friendly bioinformatics for epigenomics and NGS data in general. | |
| Bessett, Danielle | Bessett’s research centers on the sociology of reproduction, including patient experiences of reproductive processes, disparities in access to care, and knowledge about reproductive health. She co-leads the research initiative, OPEN. | |
| Bezerra, Jorge | Investigation of the developmental basis of pediatric liver disease, with a focus genetic, cellular and molecular circuitsthat control injury and survival signals. | jorge.bezerra@cchmc.org Website |
| Biagini, Jocelyn | Genetic and environmental risk factors of asthma and allergic disease; allergic disease epidemiology, progression and phenotyping (asthma, eczema, food allergy); cohort design, recruitment and retention. | Jocelyn.Biagini@cchmc.org Website |
| Blackard, Jason | Currently directs a translational research laboratory which focuses on human and mechanistic studies to understand the interactions between various viral pathogens. Using a variety of cell culture systems, molecular virology techniques, and patient-derived samples, I investigate the pathogenic and evolutionary mechanisms by which viruses interact with the host and cause disease. At present, laboratory studies involve hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis E virus (HEV), pegiviruses (HPgV; GBV-C), and HIV and include international collaborations in South Africa, Botswana, India, Nigeria, and Ghana. | blackajt@ucmail.uc.edu Website |
| Bogdanov, Vladimir | Biochemistry of Blood Coagulation, Expression and Alternative Splicing of Tissue Factor (TF) pre-mRNA in the Vasculature, Circulating TF in Health and Disease, TF and the Pathobiology of Cancer, Alternatively Spliced TF and Angiogenesis. | bogdanvr@ucmail.uc.edu Website |
| Boscolo, Elisa | Translational and molecular studies to identify new therapeutic targeted drugs for developmental vascular anomalies. | elisa.boscolo@cchmc.org Website |
| Brugmann, Samantha | Interested in craniofacial development and the etiology of craniofacial disorders. | samantha.brugmann@cchmc.org Website |
| Byrd, John | Dr. Byrd’s laboratory research focuses on preclinical studies of targeted and immune therapeutics along with development of novel pharmacodynamic models and animal systems to study new therapies in myeloid and lymphoid malignancies. Dr. Byrd has been active in developing several therapeutics that are now FDA approved for the treatment of CLL and AML. In addition, he works closely with investigators in the Bloomfield Prognostic Center, Alliance for Clinical Trials in Oncology, and Leukemia and Lymphoma Society Beat AML group to develop biomarkers that predict response to targeted therapy in leukemia. | byrd2jc@ucmail.uc.edu Website |
| Campbell, Kenneth | Our research focuses on the molecular genetics of neural development with a focus on development of the basal ganglia and surrounding ventral telencephalic regions. | kenneth.campbell@cchmc.org Website |
| Cancelas Perez, Jose | Cellular and molecular mechanisms of normal and cancer hematopoietic stem cells, and transfusion medicine. | jose.cancelas@uc.edu Website |
| Cecil, Kim | Our research employs magnetic resonance spectroscopy and imaging techniques to evaluate the effects of environmental neurotoxicants on humans. We also study neurological disorders such as creatine deficiency syndromes. | kim.cecil@cchmc.org Website |
| Chella Krishnan, Karthickeyan | Understand how host genetic variations and sex differences influence the mitochondrial (dys)function and increases the severity and outcomes of cardiometabolic diseases such as obesity, diabetes, heart failure and fatty liver disease. | chellakn@ucmail.uc.edu Website |
| Chougnet, Claire | HIV/AIDS pathogenesis; ontogeny of the immune system; immune dysfunction in aging; human immunology. | claire.chougnet@cchmc.org Website |
| Clark, Joseph | Concussion and mTBI diagnosis, management, return to play, rehabilitation and recovery. | clarkjf@ucmail.uc.edu Website |
| Cleveland, Zackary | Our research focuses on developing radiation-fee methods to quantify regional lung structure and function in patients and small animal models of disease. Specifically, we apply ultra-short echo time and hyperpolarized gas MRI to a variety
of disorders, including environmental exposure, interstitial lung disease, cystic fibrosis, and acute lung injury. | |
| Conforti, Laura | Dr. Conforti laboratory studies cancer and autoimmunity. The main focus areas are: (1) to understand the role that ion channels and the tumor microenvironment play in the failure of immunosurveillance and the resistance to immunotherapies in cancer, (2) to study how ion channels contribute to SLE, and (3) to develop nanoparticles for targeted therapies. | |
| Crone, Steven | Neural control of breathing. We develop therapies to alter activity of respiratory neurons to improve ventilation in mouse models (and patients) with neuromuscular disease or spinal cord injury. | |
| Cunningham, Tom | The Cunningham lab aims to understand the metabolic alterations that underlie developmental disorders and cancer using the toolkits of biochemistry, cell and molecular biology, mouse genetics, and computational genomics. | |
| Cushion, Melanie | Metatranscriptomics and preclinical drug development for treatment of the AIDS-related opportunistic pathogen Pneumocystis carinii. | |
| Czyzyk-Krzeska, Maria | Molecular pathways regulated by renal cancer tumor suppressor, particularly VHL. Mechanisms of oncogenic and tumorsuppressing autophagy. MicroRNA networks in control of autophagy. | czyzkm@ucmail.uc.edu Website |
| Danzer, Steve | Our lab focuses on elucidating the basic mechanisms that underlie the development of temporal lobe epilepsy. We also investigate the mechanisms that regulate the development of epilepsy comorbidities, such as stress-anxiety disorders and depression. | |
| Dasgupta, Biplab | Our laboratory is interested in elucidating mechanisms of metabolic regulation of neural development, and the discovery of novel molecular pathways that control cancer cell metabolism and survival. | Biplab.DasGupta@cchmc.org Website |
| Davidson, Sean | The overall aim of the lab is to understand the mechanisms by which the body protects itself from heart disease. We use mutagenesis and spectroscopic techniques to study the structure/function relationships of the proteins that comprise
high density lipoproteins. | davidswm@ucmail.uc.edu Website |
| Davidson, Steve | Neurobiology of chronic pain. Dissection of supraspinal circuits regulating pain using optogenetics/chemogenetics in animal models. Recovery of human peripheral neurons for neurophysiological studies of non-opioid analgesics. | |
| Deepe, George | We examine the host response to fungal pathogens, in particular Histoplasma capsulatum. Our principal goals are tounderstand the immune regulators of resistance and susceptiblity. | deepegs@ucmail.uc.edu Website |
| DeMazumder, Deeptankar | Physician-scientist in cardiac electrophysiology (EP) focusing on the mechanistic link between heart failure and sudden cardiac death in the context of patho/physiological mechanisms, novel therapies, clinically-relevant animal models,
“big data” predictive analytics and epidemiology. | deeptankar.demazumder@uc.edu Website |
| Deka, Ranjan | Epidemiology and genetics of complex diseases, particularly identifying susceptibility genes predisposing individuals to cardiometabolic diseases and type 2 diabetes. | dekar@ucmail.uc.edu Website |
| DelBello, Melissa | Neurodevelopment of childhood and adolescent bipolar and the neuropsychopharmacology of bipolar disorder inchildren and adolescents. | |
| Deshmukh, Hitesh | Using a combination of human studies and developmentally appropriate preclinical models in non-human primates and mice, our lab investigates the cellular components and molecular targets by which intestinal commensal bacteria direct development of innate defenses of the lungs in newborns. | |
| Dexheimer, Judith | Studies developing, implementing and evaluating clinical information systems, including clinical decision and artificial intelligence applications. Her research focuses on the design, implementation and evaluation of clinical decision support systems improving clinical care. | |
| Dey, Sudhansu | Molecular and genetic basis of embryo implantation. | sk.dey@cchmc.org Website |
| Divanovic, Senad | Innate immune responses; obesity; NAFLD; preterm birth. | senad.divanovic@cchmc.org Website |
| Erickson, Craig | Fragile X syndrome; autism spectrum disorders. | Craig.Erickson@cchmc.org Website |
| Esfandiari, Leyla | Dr. Esfandiari has a multidisciplinary research laboratory utilizing the cutting edge nanotechnologies and microfabrication techniques with the main focus to develop novel bioanalytical tools including highly sensitive and implantable micro/nano-scale sensors, actuators and three dimensional smart scaffolds to foster the fundamental understanding of signaling pathways in regenerative medicine, organogenesis and disease progression. Her team has also developed and patented a novel liquid biopsy technology for rapid and early diagnosis of circulating biomarkers in cancer and other diseases. | |
| Filippi, Marie Dominique | The overarching goal of my research program is to understand the molecular regulation of hematopoietic cell functions. One outstanding question of hematopoietic stem cell biology is to understand what determines HSC regenerative potential and why HSC sustain injury during replication under stress conditions such bone marrow transplantation and at steady state. My lab investigates the mechanism behind HSC injury and functional decline with bone marrow transplantation in order to provide rationale to improve bone marrow transplantation outcomes. | Marie-Dominique.Filippi@cchmc.org Website |
| Gebelein, Brian | Patterning the nervous system during development. | brian.gebelein@cchmc.org Website |
| Grimes, H. Leighton | Mechanistic and pre-translational studies of hematopoietic disorders, including marrow failure, myelodysplasia and leukemia. | lee.grimes@cchmc.org Website |
| Gross, Nina | Analysis of molecular mechanisms underlying brain disorders such as Fragile X syndrome, epilepsy and autism with the goal to identify novel treatment targets. | Christina.Gross@cchmc.org Website |
| Gu, Mingxia | We aim to develop novel therapy for regeneration of the heart, lung, and vasculature in patients with congenital cardiac and pulmonary defects. Towards this goal, we conduct translational and interdisciplinary research using patient-specific induced pluripotent stem cells (iPSCs), vessel and lung organoids, animal models, and single cell RNA/ATAC sequencing for disease modeling and high-throughput drug screening. | Mingxia.Gu@cchmc.org Website |
| Guan, Jun-Lin | The overall goals of the Guan laboratory is to understand the fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how the disruption of normal signaling pathways lead to diseases such as cancer. | guanjl@ucmail.uc.edu Website |
| Hassett, Daniel | We work on CF lung disease. We patented a novel treatment that has been through animal toxicology and human phase I trials, acidified nitrite. | daniel.hassett@uc.edu Website |
| Hegde, Rashmi | Elucidation of molecular mechanisms and therapeutic strategies for pediatric solid tumors (Ewing sarcoma, Rhabdomyosarcoma, glioblastoma), proliferative retinopathies (Retinopathy of Prematurity and Diabetic Retinopathy), and Pulmonary Arterial Hypertension. | Rashmi.Hegde@cchmc.org Website |
| Heikenfeld, Jason | Disruptive and entrepreneurial device research that is currently focused on advancing the frontiers of biosensors. | heikenjc@ucmail.uc.edu Website |
| Herman, James | Structural, functional and molecular biological principles underlying brain stress integration. | HERMANJS@UCMAIL.UC.EDU Website |
| Herr, Andrew | Biophysical and structural studies of proteins involved in bacterial biofilm formation, humoral immune responses, andthrombosis. | andrew.herr@cchmc.org Website |
| Herro, Rana | Fibrosis is the end result of many inflammatory, autoimmune, and malignant diseases, often triggered by epithelial injury. It is characterized by an inflammatory phase followed by tissue remodeling leading to the uncontrolled accumulation of extracellular matrix proteins expressed by myofibroblasts, in failing internal organs. Fibrosis is responsible for 45% of death in USA and current therapies slow the rate of decline or limit inflammation without effectively reversing tissue remodeling and fibers’ deposition. Hence the need to develop novel anti-fibrotic drugs that limit myofibroblast survival and activity to suppress disease symptoms. The Herro’s lab investigates the involvement of TNF Superfamily members in fibrosis associated with Idiopathic Pulmonary Fibrosis, Systemic Sclerosis, Non-Alcoholic Steatohepatitits, Asthma and Atopic Dermatitis, among others. Using a Human-Mouse-Human strategy, Dr Herro’s team aims to identify drug targets (including TNF molecules) in fibrotic biopsies of patients, validate the implication of such targets and pathways in murine models of disease using conditional or full knockout mice, and translate these findings to humans using in vitro models ( organ-on-chip cultures of primary human cells perpetuating disease in patients). This should establish a proof-of concept to target these molecules in therapeutic intervention to cure fibrosis in humans. | rana.herro@cchmc.org Website |
| Hershey, Gurjit Khurana | Focuses on delineating the genetic and environmental factors that promote asthma /allergy phenotypes and dissecting the mechanisms by which they confer risk, and significantlyadvancing the knowledge of the immunomodulatory roles of allergens and other exposures. | gurjit.hershey@cchmc.org Website |
| Hildeman, David | Molecular biology of antigen-specific T cells, including cell signaling, apoptosis, and development of memory. Noveltherapeutics to eliminate T cells causing autoimmunity and transplant rejection. | david.hildeman@cchmc.org Website |
| Ho, Chia-Chi | Apply micro fabrication and nanotechnology to construct precisely designed geometrical networks of neuronal cluster and bottom up assembly of tissues. | chiachi.ho@uc.edu Website |
| Hogenesch, John | Our lab studies genome and circadian biology in mammals. We focus on how we can leverage this knowledge to improve human health. | John.Hogenesch@cchmc.org Website |
| Holland, Christy | Diagnostic and therapeutic ultrasound and image-guided targeted drug delivery. | |
| Hong, Christian | Roles of circadian rhythms in the gastrointestinal system, development of colorectal cancer and its treatment. | christian.hong@uc.edu Website |
| Hui, David | Influence of genetic factors such as apoE, LDL receptor family proteins, and pancreatic digestive enzymes, in modulating cardiometabolic diseases, including atherosclerosis, obesity, and diabetes. | huidy@ucmail.uc.edu Website |
| Hwa, Vivian | Our lab is interested in studying patients with severe growth disorders in order to understand the molecular basis of growth and its perturbations. | Vivian.Hwa@cchmc.org Website |
| Hyacinth, Hyacinth | My overall research interest is to understand the biological basis for racial disparity in stroke, cognitive impairment and dementia and to utilize this knowledge for the development of more targeted therapies and prevention strategies. | hyacinhi@ucmail.uc.edu Website |
| Jankowski, Michael | Our lab is interested in the molecular mechanisms of sensory neuron plasticity after peripheral injuries in adults and neonates. | |
| Jegga, Anil | Design, develop and apply novel and robust computational approaches that will accelerate the diffusion of genomics into biomedical research and education and convert the genomics data deluge into systematized knowledge to enable translational research. Research focus areas: computational drug discovery and drug repositioning, network medicine, systems biology of disease and drug response | |
| Jiang, Rulang | Mechanisms of craniofacial, kidney, and musculoskeletal organ development. | rulang.jiang@cchmc.org Website |
| Kalfa, Theodosia | Erythropoiesis studies focused on signaling and cytoskeletal requirements in erythroblast cytokinesis and enucleation. Role of Rac GTPases and NADPH oxidase in generation of ROS from sickle cells and their role in SCD pathogenesis. | theodosia.kalfa@cchmc.org Website |
| Kalin, Tanya | Mechanisms of Interstitial lung diseases. Idiopathic Pulmonary Fibrosis. Transcriptional regulation of cancer progression and metastasis. Tumor microenvironment. Chemotherapeutic drug development. | tatiana.kalin@cchmc.org Website |
| Kalinichenko, Vladimir | Transcriptional regulation of epithelial and endothelial cell functions during lung embryonic development and lung carcinogenesis; winged helix/forkhead box (Fox) proteins and their role in regulating cell signaling pathways required for cellular proliferation, differentiation, motility and survival; identify and increase understanding of currently unknown mechanisms that cause human lung malformations and promote lung cancer formation. | |
| Kopan, Raphael | Mechanism of notch signaling, its role in organogenesis, the impact of aging on stem cells and the chromatinregulation by transcription factors at the single cell level. | |
| Kottyan, Leah | The Kottyan lab works to identify the molecular mechanisms mediating the genetic etiology of Systemic lupus erythematous and Eosinophilic Esophagitis. | |
| Kovall, Rhett | Transcription regulation in the Notch signaling pathway; aberrant Notch signaling underlying the pathogenesis of human diseases including congenital defects, cardiovascular disease, and cancer. | |
| Kranias, Litsa | Elucidate the role of Ca-handling and Ca-signaling in myocardial function and survival with the aim to provide fundamental mechanistic insights and identify novel therapeutic modalities. | litsa.kranias@uc.edu Website |
| Kumar, Ashish | We are studying the biology of infant leukemia to identify novel therapeutic approaches. | ashish.kumar@cchmc.org Website |
| Lang, Richard | Non-visual opsins and light response pathways in development and homeostasis | richard.lang@cchmc.org Website |
| Langevin, Scott | My area of expertise is molecular epidemiology and cancer epigenetics, primarily for malignancies originating in the aerodigestive tract. | langevst@ucmail.uc.edu Website |
| Le Cras, Tim | Vascular Malformations & Disease in Children | Tim.LeCras@cchmc.org Website |
| Lewkowich, Ian | My lab studies the pathogenesis of severe allergic asthma. Studies seek to identify mechanisms through which early life exposures, including those to the mother and/or father contribute to asthma development. | Ian.Lewkowich@cchmc.org Website |
| Lu, Richard Q. | Molecular mechanisms of glial biology, neurological disorders, and brain cancers; Gene regulatory networks for functional regeneration in demyelinating diseases. Novel therapeutic approaches to brain tumors. | Richard.Lu@cchmc.org Website |
| Lucas, Daniel | The Lucas lab uses state of the art imaging approaches to understand the physiology of normal hematopoiesis and the pathology of acute myeloid leukemia. | Daniel.Lucas@cchmc.org Website |
| Luo, Agnes | Utilizing a combination of cell-type specific genetic modification and pharmacological manipulations, our research focuses on key molecular pathways that promote neuroprotection (early intervention) or enhance neuroregeneration (late intervention) in neurological diseases. | LUOY2@ucmail.uc.edu Website |
| Mackenzie, Bryan | Iron homeostasis and disorders of iron metabolism. Molecular physiology and structure–function of human iron-transport proteins (DMT1, ferroportin, ZIP14). | bryan.mackenzie@uc.edu Website |
| Makarewich, Catherine | Our lab investigates the molecular mechanisms that underlie the pathophysiology of cardiovascular disease and skeletal muscle disorders. | Cat.Makarewich@cchmc.org Website |
| Malik, Punam | Research focus is gene therapy or gene editing of hematopoietic stem cells to correct hemoglobinopathies and other stem cell disorders, stem cell maintenance during genetic manipulation, non-toxic conditioning. Also, studies on pathophysiology of sickle cell disease, to reduce morbidity and mortality from sickle cell disease. | |
| Mast, Douglas T. | Therapeutic applications of medical ultrasound including image guidance and control of cancer ablation, biofeedback in speech therapy, ultrasound-enhanced drug delivery, and noninvasive measurements of tissue biomechanics. | |
| McCormack, Francis | Particularly interested in the antimicrobial, antioxidant, and immunomodulatory roles of surfactant proteins A and D in the alveolar space. | frank.mccormack@uc.edu Website |
| Mersha,Tesfaye | Dr. Mersha’s research interests lie in combining quantitative, ancestry and statistical genomics to unravel genetic and non-genetic contributions to asthma and asthma-related allergic disorders in human populations. | |
| Millay, Douglas | We are interested the mechanisms that govern the development and regeneration of skeletal muscle. Our current focus is to understand the molecules and mechanisms that mediate myoblast fusion. | Douglas.Millay@cchmc.org Website |
| Miller, William | The Miller laboratory is interested in the mechanisms by which viral pathogens such as the cytomegaloviruses manipulate and alter host cell G-protein coupled receptor signaling pathways to facilitate viral dissemination. | MILLERWE@UCMAIL.UC.EDU Website |
| Miraldi, Emily |
Systems biology to immunoengineer, building mathematical models of the immune system from high-dimensional genomics measurements, to re-engineer immune responses in the context of autoimmune and other diseases. | |
| Molkentin, Jeffery | Transcriptional control of cardiac development and the molecular signaling pathways involved in cardiac hypertrophy. | jeff.molkentin@cchmc.org Website |
| Nakamura, Takahisa | Molecular mechanism focusing on RNA networks for inter- and intra-cellular communications in the pathogenesis of metabolic diseases, particularly obesity, type 2 diabetes, and non-alcoholic fatty liver diseases. | takahisa.nakamura@cchmc.org Website |
| Norman, Andrew | Developing pharmacotherapies for drug abuse using self-administration behavior as a bioassay system to measure the absolute pharmacodynamic and pharmacokinetic potencies of receptor agonists and antagonists. | andrew.norman@uc.edu Website |
| Owens, Phillip | The primary focus of my research is to examine the effects of coagulation proteins, proteases, and receptors in the pathogenesis cardiovascular disease (CVD), specifically atherosclerosis and abdominal aortic aneurysms (AAAs). | phillip.owens@uc.edu Website |
| Ozbudak, Ertugrul | We aim to achieve a systems-level understanding of robust spatiotemporal pattern formation (e.g. rhythmic segmentation of somites) and cell fate determination by integrating quantitative experiments with computational modeling. These efforts aim to provide a mechanistic understanding of congenital diseases. | |
| Pan, Dao | Conducted translational research on in vivo or stem cell-mediated gene therapy for patients with neurological lysosomal storage diseases; interested in CNS pathogenesis and brain drug delivery. | Dao.Pan@cchmc.org Website |
| Park, Joo-Seop | The goal of the Park lab is to understand how signaling pathways and transcription factors coordinate to make cell fate decisions in the kidney during development, homeostasis, and disease. | Joo-Seop.Park@cchmc.org Website |
| Pasare, Chandrashekhar (Shekhar) | Toll-like receptor signaling, Dendritic cell biology and Innate control of adaptive immunity. Goals of our lab are to understand the cellular and molecular mechanisms by which the innate immune system induces inflammation and instructs adaptive immune system to mount protective immune responses against pathogens. | Chandrashekhar.Pasare@cchmc.org Website |
| Perl, Anne-Karina | Understanding the molecular and cellular mechanisms that regulate lung fibroblast function and differentiation during development, alveolar regeneration, fibrosis and lung transplant biology. | anne.perl@cchmc.org Website |
| Pestian, John | Dr. Pestian's lab focuses on developing advanced technology for the care of neuropsychiatric illness. The lab also focuses on earlier identification of individuals at risk of suicide, depression, and bipolar and anxiety disorders using verbal and non-verbal language. | john.pestian@cchmc.org Website |
| Pinney, Susan | Cancer epidemiology, reproductive epidemiology, screening, environmental biomarkers, exposure metrics, genetic epidemiology, risk communication | susan.pinney@uc.edu Website |
| Plas, David | We study signal transduction control of oncogenic metabolic programs in cancers of the brain, blood and breast tissues. Our approaches include genetic/genomic analysis, metabolomics, patient-donated tumor models, mouse modeling and cell biology. | david.plas@uc.edu Website |
| Qi, Xiaoyang | Focused on developing novel theragnostic nanovesicles which have the potential to offer a targeted, potent, broad, and safe therapeutic efficacy and diagnostic application for cancer patient. | xiaoyang.qi@cchmc.org Website |
| Qualls, Joseph | Immunology; innate immunity; macrophage biology; amino acid metabolism; intracellular pathogenesis. | |
| Rance, Mark | Application of NMR spectroscopy to macro-molecular structure; The structure/dynamics/function relationship in proteins and protein-nucleic acid complexes. | rancema@ucmail.uc.edu Website |
| Ratner, Nancy | Development of the nervous system; peripheral nerve tumor formation; Genetic mutations in tumor suppressor genes; Ras signal transduction. | nancy.ratner@cchmc.org Website |
| Reponen, Tiina | Indoor allergens and mold; airborne allergens, bacteria, and fungi; exposure assessment in population-based studies. | Tiina.Reponen@uc.edu Website |
| Reyes, Teresa | The Reyes lab examines the effects of early life environmental adversity on cognition, incorporating neuroimmune and DNA methylation analyses. | reyesta@ucmail.uc.edu Website |
| Rothenberg, Marc | Mechanisms of Allergic Inflammation.Genomic Analysis, Personalized Medicine, and Translational Research Inquiry of Allergy, with focus on Eosinophilic Disorders. | |
| Ryan, Patrick | Epidemiology; air pollution; exposure assessment. | |
| Sadayappan, Sakthivel | Heart failure is the number one killer worldwide with heart failure with preserved ejection fraction (HFpEF), comprising ~50% of heart failure cases. Therefore, ongoing studies in the lab are aimed at defining the molecular mechanism(s) underlying the development of HFpEF, particularly in the setting of type 2 diabetes. | |
| Sah, Renu | The focus of my research program is to understand mechanisms underlying fear and anxiety behaviors and how they manifest into disorders such as Panic Disorder (PD) and Posttraumatic Stress disorder (PTSD). | |
| Salomonis, Nathan | The Salomonis lab is working to understand the role of alternative splicing in human development and disease and integrate these results with epigenetic, gene expression, proteomic and single-cell sequencing data. | Nathan.Salomonis@cchmc.org Website |
| Sasaki, Atsuo | GTP energy metabolism; Signaling; Brain tumors; Brain metastatic cancers; Metabolic diseases; NAFLD; Biochemistry and cell biology combined with multidisciplinary approaches (e.g., X-ray structure, CryoEM, NMR, drug development). | sasakiao@UCMAIL.UC.EDU Website |
| Schultz, Jo El | Role of opioid peptides and growth factors in cardiovascular function and response to stress and injury; mechanisms and pathology of cardiac function, cardiac growth and ischemia-reperfusion injury; role of growth factors in angiogenesis and ischemia-induced collateralization. | schuljo@ucmail.uc.edu Website |
| Shao, Wenhai | We study the pathologic mechanisms and therapeutics of lupus and lupus nephritis with molecular and cellular tools in mouse models of lupus. | shaowi@ucmail.uc.edu Website |
| Shearn, Jason | Create better tissue engineered constructs for implantation and understand the mechanical environment for normal, injured and repairing tendons and ligaments. | jason.shearn@uc.edu Website |
| Sherenian, Michael | Atopic dermatitis (eczema); asthma; food allergies; allergic rhinitis; fibrosis; genetic basis of allergic disease | Michael.Sherenian@cchmc.org Website |
| Shin, Soona | Mechanisms of liver cancer development with a focus on paracrine interactions and cell identity. | Soona.Shin@cchmc.org Website |
| Soleimani, Manoocher | Cellular and molecular mechanisms of pH regulation in the kidney. | soleimm@ucmail.uc.edu Website |
| Spearman, Paul | Pediatric infectious disease; HIV assembly, HIV biology/pathogenesis, HIV vaccines; vaccines and therapeutics for children (clinical trials). | paul.spearman@cchmc.org Website |
| Starczynowski, Daniel | Interested in the molecular, cellular, and genetic basis of hematologic malignancies, with a specific focus on Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML). | |
| Steckl, Andrew | Nanoelectronics, biotech materials and devices. | a.steckl@uc.edu Website |
| Takebe, Takanori | Takebe Lab investigates key biological principles governing organogenesis, that can be leveraged for designing stem-cell-derived organoid system towards future biomedical application. | Takanori.Takebe@cchmc.org Website |
| Thompson, Thomas | Structure-function studies of the TGFbeta family and of apolipoproteins. | thompstb@ucmail.uc.edu Website |
| Tilburgs, Tamara | Tolerance and Immunity at the maternal-fetal interface in human pregnancy | Tamara.Tilburgs@cchmc.org Website |
| Timberlake, Jeffrey | Research interests include the sociology of population, urban sociology, race and ethnicity, and quantitative research methods. | timberjm@ucmail.uc.edu Website |
| Timchenko, Nikolai | Dr. Timchenko is working with molecular mechanisms of Liver Cancer and Non-Alcoholic Fatty Liver Disease. His work focuses on the epigenetic changes that cause these liver diseases. | Website |
| Tranter, Michael | My lab focuses on the molecular mechanisms that drive cardiometabolic diseases. Specific projects focus on the post-transcriptional gene regulation by the RNA binding protein Human antigen R (HuR) in the setting of (1) cardiac fibrosis in hypertrophy and heart failure, (2) inflammation and adaptive cardiac remodeling following ischemia/reperfusion injury, and (3) thermogenesis and metabolic homeostasis in brown and beige adipocytes. | |
| Trapnell, Bruce | Research on rare lung diseases including pulmonary alveolar proteinosis, cystic fibrosis, alpha-1 antitrypsin deficiency and lymphangioleiomyomatosis. Mechanisms of alveolar macrophage function. Experimental approaches include molecular techniques using gene knockout, transgenic and conditional gene expression mouse models and non-human primates, in vitro and in vivo viral gene transfer, and bone marrow transplantation. | |
| Ulrich-Lai, Yvonne | Identify the neural and hormonal substrates that are responsible for the interactions among diet, obesity and stress. | yvonne.ulrich-lai@uc.edu Website |
| Vorhees, Charles | We study the synaptic protein Latrophilin-3, manganese transporter SLC30A10, pyrethroid pesticides on brain development, and effects of high dose-rate proton vs. conventional proton exposures on brain and behavior in rats. | Charles.Vorhees@cchmc.org Website |
| Waclaw, Ronald | Molecular genetic mechanisms of basal ganglia development. Impact of RASopathy mutations on neurodevelopment. | Ronald.Waclaw@cchmc.org Website |
| Waggoner, Stephen | NK cells control vaccine efficacy and disease pathogenesis during infection by killing T cells. Targeting NK-cell immunoregulation may facilitate prevention or treatment of human diseases, including autoimmunity. | Stephen.Waggoner@cchmc.org Website |
| Waltz, Susan | Molecular analysis of growth factors and receptor tyrosine kinases in tumorigenesis, organ function, and cellulartrauma. | waltzse@ucmail.uc.edu Website |
| Waxman, Joshua | Molecular mechanisms and signaling of organogenesis. Molecular and genetic regulation of cardiovascular development. | joshua.waxman@cchmc.org Website |
| Way, Sing Sing | Individuals are unique vulnerable during in utero development and the early postnatal period. Immunological tools are used investigate susceptibility in these unique developmental windows. | singsing.way@cchmc.org Website |
| Weirauch, Matt | The Weirauch lab uses computational and experimental tools to understand the mechanisms of gene transcriptional regulation and how these mechanisms go awry in disease states. | |
| Weiss, Alison | Research in the Weiss lab focusses on studying the intestinal microbiome and intestinal pathogens using stem-cell derived human intestinal organoids with an emphasis on enteric infectious diseases and cancer. | weissaa@ucmail.uc.edu Website |
| Wells, James | Edoderm organogenesis and promoting the differentiation of embryonic stem cells into therapeutic endoderm derivatives. | james.wells@cchmc.org Website |
| Wells, Susanne | Human papillomavirus, cervical cancer, head and neck cancer, tissue engineering. | susanne.wells@cchmc.org Website |
| Whitsett, Jeffrey | Organ morphogenesis, gene regulation, cell differentiation, respiratory disease. | jeffrey.whitsett@cchmc.org Website |
| Wikenheiser-Brokamp, Kathryn | Molecular and genetic basis of lung development and disease with specific interest in Rb/p16, p53 and Dicer/miRNA signaling pathways. | kathryn.wikenheiser-brokamp@cchmc.org Website |
| Wise-Draper, Trisha | The laboratory focuses on mechanisms underlying resistance to immunotherapy, including T-cell dysfunction, and the potential role of NK cells and the microenvironment for head and neck and other cancers. | wiseth@ucmail.uc.edu Website |
| Wohleb, Eric | Our research group studies how neuroimmune systems shape synaptic function and behavior in pathological and physiological conditions. To this end, we use multi-disciplinary approaches, including flow cytometry and cell sorting, cell type-specific molecular analyses (RNA-Seq), viral-mediated genetic and pharmacological manipulations, and imaging techniques to study pathways mediating neuro-immune interactions. We strive for scientific excellence and integrity; and we value a supportive work environment that fosters provocative ideas and collective efforts to achieve goals. | wohlebes@ucmail.uc.edu Website |
| Woods, Jason | Overall goals are to develop state-of-the-art respiratory and cardiac MRI (e.g., with hyperpolarized gases) and CT and to translate these new modalities into the clinic via translational studies. | |
| Yolton, Kimberly | Dr. Yolton’s research focuses on early life exposure to a variety of environmental toxicants, opiates, and maternal stress, and their potential impact on neurobehavioral outcomes spanning early infancy through adolescence. | Kimberly.Yolton@cchmc.org Website |
| Yu, Jane | Molecular basis of female prevalent lung diseases | |
| Yutzey, Katherine | Molecular mechanisms of heart development and disease | katherine.yutzey@cchmc.org Website |
| Zacharias, William | The Zacharias Lung Lab studies the mechanisms of development and regeneration in the mammalian lung with a focus on gene regulatory networks, epigenetic landscapes, and niche interactions of epithelial progenitor cells. Our goal is to understand why and how lung progenitor cells participate in functional lung regeneration, and identify pathways with therapeutic potential to help patients with acute and chronic lung disease. | William.Zacharias@cchmc.org Website |
| Zhang, Xiaoting | Our research focuses on transcriptional and epigenetic gene regulation in breast cancer metastasis and treatment resistance, and the development of RNA nanotechnology-based next-generation therapeutics. | zhangxt@ucmail.uc.edu Website |
| Zheng, Yi | Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions. | yi.zheng@cchmc.org Website |
| Zimmerman, Nives | The Zimmermann lab studies the pathophysiology of eosinophil and mast cell-associated disorders, including neoplasms. The approaches include in vitro and in vivo modeling, as well as translational patient-based research. | zimmerns@ucmail.uc.edu Website |
| Zorn, Aaron | We use animal models, pluripotent stem cells and cutting-edge genomics to elucidate the gene regulatory networks controlling organogenesis. This informs the basis of birth defects and strategies to generate human organoid tissue for regenerative medicine. | Aaron.Zorn@cchmc.org Website |
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Medical ScientistTraining Program
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Email: mstp@uc.edu