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Photo of Ishita Basu

Ishita Basu

Research Assistant Professor

Neurosurgery | College of Medicine

Education/Credentials
  • Research Instructor: Massachusetts General Hospital
  • Research Fellowship: Massachusetts General Hospital
  • Postdoctoral Fellowship: John Hopkins University
  • Doctoral Degree: University of Illinois
Contact Information
Research Interests

1) Develop data driven and model based approaches for understanding brain rhythms underlying pathological states in patients with neurologic and psychiatric disorders.  
2) Design brain stimulation paradigms for modulating pathologic brain dynamics towards healthy state.

Peer Reviewed Publications

Basu, Ishita; Yousefi, Ali; Crocker, Britni; Zelmann, Rina; Paulk, Angelique C; Peled, Noam; Ellard, Kristen K; Weisholtz, Daniel S; Cosgrove, G Rees; Deckersbach, Thilo; Eden, Uri T; Eskandar, Emad N; Dougherty, Darin D; Cash, Sydney S; Widge, Alik S 2021. Closed-loop enhancement and neural decoding of cognitive control in humans. Nature biomedical engineering, ,

Olsen, Sarah T; Basu, Ishita; Bilge, Mustafa Taha; Kanabar, Anish; Boggess, Matthew J; Rockhill, Alexander P; Gosai, Aishwarya K; Hahn, Emily; Peled, Noam; Ennis, Michaela; Shiff, Ilana; Fairbank-Haynes, Katherine; Salvi, Joshua D; Cusin, Cristina; Deckersbach, Thilo; Williams, Ziv; Baker, Justin T; Dougherty, Darin D; Widge, Alik S 2020. Case Report of Dual-Site Neurostimulation and Chronic Recording of Cortico-Striatal Circuitry in a Patient With Treatment Refractory Obsessive Compulsive Disorder. Frontiers in human neuroscience, 14 , 569973

Zelmann, Rina; Paulk, Angelique C; Basu, Ishita; Sarma, Anish; Yousefi, Ali; Crocker, Britni; Eskandar, Emad; Williams, Ziv; Cosgrove, G Rees; Weisholtz, Daniel S; Dougherty, Darin D; Truccolo, Wilson; Widge, Alik S; Cash, Sydney S 2020. CLoSES: A platform for closed-loop intracranial stimulation in humans. NeuroImage, 223 , 117314

Yousefi, Ali; Basu, Ishita; Paulk, Angelique C; Peled, Noam; Eskandar, Emad N; Dougherty, Darin D; Cash, Sydney S; Widge, Alik S; Eden, Uri T 2019. Decoding Hidden Cognitive States From Behavior and Physiology Using a Bayesian Approach. Neural computation, 31 9, 1751-1788

Basu, Ishita; Crocker, Britni; Farnes, Kara; Robertson, Madeline M; Paulk, Angelique C; Vallejo, Deborah I; Dougherty, Darin D; Cash, Sydney S; Eskandar, Emad N; Kramer, Mark M; Widge, Alik S 2018. A neural mass model to predict electrical stimulation evoked responses in human and non-human primate brain. Journal of neural engineering, 15 6, 066012

Graupe, Daniel; Khobragade, Nivedita; Tuninetti, Daniela; Basu, Ishita; Slavin, Konstantin V; Verhagen Metman, Leo 2018. Who May Benefit From On-Demand Control of Deep Brain Stimulation? Noninvasive Evaluation of Parkinson Patients. Neuromodulation : journal of the International Neuromodulation Society, 21 6, 611-616

Yousefi, Ali; Paulk, Angelique C; Basu, Ishita; Mirsky, Jonathan L; Dougherty, Darin D; Eskandar, Emad N; Eden, Uri T; Widge, Alik S 2018. COMPASS: An Open-Source, General-Purpose Software Toolkit for Computational Psychiatry. Frontiers in neuroscience, 12 , 957

Widge, Alik S; Ellard, Kristen K; Paulk, Angelique C; Basu, Ishita; Yousefi, Ali; Zorowitz, Samuel; Gilmour, Anna; Afzal, Afsana; Deckersbach, Thilo; Cash, Sydney S; Kramer, Mark A; Eden, Uri T; Dougherty, Darin D; Eskandar, Emad N 2017. Treating refractory mental illness with closed-loop brain stimulation: Progress towards a patient-specific transdiagnostic approach. Experimental neurology, 287 Pt 4, 461-472

Basu, Ishita; Kudela, Pawel; Korzeniewska, Anna; Franaszczuk, Piotr J; Anderson, William S 2015. A study of the dynamics of seizure propagation across micro domains in the vicinity of the seizure onset zone. Journal of neural engineering, 12 4, 046016

Basu, Ishita; Anderson, William 2014. Bipolar vs monopolar stimulation for cortical mapping: which is better? Neurosurgery, 75 4, N16-7

Basu, Ishita; Anderson, William 2014. Bilateral representation of sensory-motor transformations. Neurosurgery, 75 2, N15-7

Basu, Ishita; Kudela, Pawel; Anderson, William S 2014. Determination of seizure propagation across microdomains using spectral measures of causality. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2014 , 6349-52

Graupe, Daniel; Tuninetti, Daniela; Slavin, Konstantin V; Basu, Ishita 2014. Closed-loop electrochemical feedback system for DBS. Journal of neurosurgery, 121 3, 762-3

Shukla, Pitamber; Basu, Ishita; Tuninetti, Daniela 2014. Towards closed-loop deep brain stimulation: decision tree-based essential tremor patient's state classifier and tremor reappearance predictor. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2014 , 2605-8

Shukla, Pitamber; Basu, Ishita; Tuninetti, Daniela; Graupe, Daniel; Slavin, Konstantin V 2014. On modeling the neuronal activity in movement disorder patients by using the Ornstein Uhlenbeck process. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2014 , 2609-12

Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Shukla, Pitamber; Slavin, Konstantin V; Metman, Leo Verhagen; Corcos, Daniel M 2013. Pathological tremor prediction using surface electromyogram and acceleration: potential use in 'ON-OFF' demand driven deep brain stimulator design. Journal of neural engineering, 10 3, 036019

Shukla, Pitamber; Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Slavin, Konstantin V 2012. A neural network-based design of an on-off adaptive control for Deep Brain Stimulation in movement disorders. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2012 , 4140-3

Basu, Ishita; Tuninetti, Daniela; Graupe, Daniel; Slavin, Konstantin V 2011. Adaptive control of deep brain stimulator for essential tremor: entropy-based tremor prediction using surface-EMG. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2011 , 7711-4

Basu, Ishita; Graupe, Daniel; Tuninetti, Daniela; Slavin, Konstantin V 2010. Stochastic modeling of the neuronal activity in the subthalamic nucleus and model parameter identification from Parkinson patient data. Biological cybernetics, 103 4, 273-83

Basu, Ishita; Tuninetti, Daniela; Graupe, Daniel; Slavin, Konstantin V 2010. Stochastic modeling of the neuronal activity in the thalamus of Essential Tremor patient. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2010 , 1461-4

Graupe, Daniel; Basu, Ishita; Tuninetti, Daniela; Vannemreddy, Prasad; Slavin, Konstantin V 2010. Adaptively controlling deep brain stimulation in essential tremor patient via surface electromyography. Neurological research, 32 9, 899-904

Basu, Ishita; Robertson, Madeline M; Crocker, Britni; Peled, Noam; Farnes, Kara; Vallejo-Lopez, Deborah I; Deng, Helen; Thombs, Matthew; Martinez-Rubio, Clarissa; Cheng, Jennifer J; McDonald, Eric; Dougherty, Darin D; Eskandar, Emad N; Widge, Alik S; Paulk, Angelique C; Cash, Sydney S . Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes. Brain stimulation, 12 4, 877-892