Education/CredentialsPostdoctoral Associate: Yale University School of Medicine (Neurophysiology of Pain)Master's Degree: Peking Union Medical College & Chinese Academy of Medical Sciences (Neurophysiology)Medical Degree: Shandong University Contact Information Medical Sciences Building 3413 Office 513-646-6111 Email zhangj4@ucmail.uc.edu Research InterestsPhysiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain Peer Reviewed Publications Qualls, K. A.; Xie, W.; Zhang, J.; Luckemeyer, D. D.; Lackey, S. V.; Strong, J. A.; Zhang, J. M. 2024. Mineralocorticoid Receptor Antagonism Reduces Inflammatory Pain Measures in Mice Independent of the Receptors on Sensory Neurons Neuroscience, 541 , 64-76Silveira Prudente, A.; Hoon Lee, S.; Roh, J.; Luckemeyer, D. D.; Cohen, C. F.; Pertin, M.; Park, C. K.; Suter, M. R.; Decosterd, I.; Zhang, J. M.; Ji, R. R.; Berta, T. 2024. Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice Brain Behav Immun, 117 , 51-65Berta, T.; Strong, J. A.; Zhang, J. M.; Ji, R. R. 2023. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update Expert Opin Ther Targets, 27 8 , 665-678Luckemeyer, D. D.; Xie, W.; Prudente, A. S.; Qualls, K. A.; Tonello, R.; Strong, J. A.; Berta, T.; Zhang, J. M. 2023. The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor beta in a Mouse Model of Radiculopathy Neurosci Bull, 39 9 , 1363-1374Tonello, R.; Silveira Prudente, A.; Hoon Lee, S.; Faith Cohen, C.; Xie, W.; Paranjpe, A.; Roh, J.; Park, C. K.; Chung, G.; Strong, J. A.; Zhang, J. M.; Berta, T. 2023. Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain Brain Behav Immun, 113 , 401-414Zheng, Q.; Xie, W.; Luckemeyer, D. D.; Lay, M.; Wang, X. W.; Dong, X.; Limjunyawong, N.; Ye, Y.; Zhou, F. Q.; Strong, J. A.; Zhang, J. M.; Dong, X. 2022. Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain Neuron, 110 2 , 209-220 e6Zhu, X.; Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2022. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model Pain, 163 1 , e106-e120Zhang, L.; Xie, W.; Zhang, J.; Shanahan, H.; Tonello, R.; Lee, S. H.; Strong, J. A.; Berta, T.; Zhang, J. M. 2021. Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy Brain Behav Immun, 91 2 , 556-567Ibrahim, S. I. A.; Strong, J. A.; Qualls, K. A.; Ulrich-Lai, Y. M.; Zhang, J. M. 2020. Differential Regulation of the Glucocorticoid Receptor in a Rat Model of Inflammatory Pain Anesth Analg, 131 1 , 298-306Tonello, R.; Xie, W.; Lee, S. H.; Wang, M.; Liu, X.; Strong, J. A.; Zhang, J. M.; Berta, T. 2020. Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice Anesthesiology, 132 6 , 1540-1553Xie, W.; Strong, J. A.; Zhang, J. M. 2020. Localized sympathectomy reduces peripheral nerve regeneration and pain behaviors in 2 rat neuropathic pain models Pain, 161 8 , 1925-1936Dai, J.; Ding, Z.; Zhang, J.; Xu, W.; Guo, Q.; Zou, W.; Xiong, Y.; Weng, Y.; Yang, Y.; Chen, S.; Zhang, J. M.; Song, Z. 2019. Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus Anesth Analg, 129 6 , 1733-1741Ren, X.; Roessler, A. E.; Lynch, T. L. th; Haar, L.; Mallick, F.; Lui, Y.; Tranter, M.; Ren, M. H.; Xie, W. R.; Fan, G. C.; Zhang, J. M.; Kranias, E. G.; Anjak, A.; Koch, S.; Jiang, M.; Miao, Q.; Wang, Y.; Cohen, A.; Rubinstein, J.; Weintraub, N. L.; Jones, W. K. 2019. Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time Am J Physiol Heart Circ Physiol, 316 3 , H543-H553Schappacher, K. A.; Xie, W.; Zhang, J. M.; Baccei, M. L. 2019. Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence Pain, 160 3 , 645-657Xiao, Y.; Barbosa, C.; Pei, Z.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2019. Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies J Neurosci, 39 8 , 1539-1550Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2019. Role of Na(V)1.6 and Na(V)beta4 Sodium Channel Subunits in a Rat Model of Low Back Pain Induced by Compression of the Dorsal Root Ganglia Neuroscience, 402 1 , 51-65Bang, S.; Yoo, J.; Gong, X.; Liu, D.; Han, Q.; Luo, X.; Chang, W.; Chen, G.; Im, S. T.; Kim, Y. H.; Strong, J. A.; Zhang, M. Z.; Zhang, J. M.; Lee, S. Y.; Ji, R. R. 2018. Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies Neurosci Bull, 34 1 , 22-41Ibrahim, S. I. A.; Xie, W.; Strong, J. A.; Tonello, R.; Berta, T.; Zhang, J. M. 2018. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain Front Cell Neurosci, 12 1 , 453Li, A. L.; Zhang, J. D.; Xie, W.; Strong, J. A.; Zhang, J. M. 2018. Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models Neurosci Bull, 34 1 , 85-97Liu, Z.; Chen, S.; Qiu, C.; Sun, Y.; Li, W.; Jiang, J.; Zhang, J. M. 2018. Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats Front Cell Neurosci, 12 5 , 495Lu, G. F.; Zhang, J. M.; An, J. X.; Oian, X. Y.; Wang, Y.; Lin, S. Y.; Williams, J. P. 2018. Enhanced Pain Sensitivity with Systemic Ultrastructural Changes of the Nervous Systems after Cobra Venom Injection is Reversed by Electroacupuncture Treatment Pain Physician, 21 5 , E509-E521Song, Z.; Xie, W.; Strong, J. A.; Berta, T.; Ulrich-Lai, Y. M.; Guo, Q.; Zhang, J. M. 2018. High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner Pain, 159 9 , 1731-1741Xie, W.; Strong, J.A.; Zhang, J.-M. 2018. SCN8A (Nav1.6): gate to chronic pain (review) J Anesth Perioper Med, 5 6 , 293-305Barbosa, C.; Xiao, Y.; Johnson, A. J.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2017. FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons Pflugers Arch, 469 2 , 195-212Ding, Z.; Xu, W.; Zhang, J.; Zou, W.; Guo, Q.; Huang, C.; Liu, C.; Zhong, T.; Zhang, J. M.; Song, Z. 2017. Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain Int J Cancer, 140 2 , 411-422Song, Z.; Xie, W.; Chen, S.; Strong, J. A.; Print, M. S.; Wang, J. I.; Shareef, A. F.; Ulrich-Lai, Y. M.; Zhang, J. M. 2017. High-fat diet increases pain behaviors in rats with or without obesity Sci Rep, 7 1 , 10350Xie, W.; Strong, J. A.; Zhang, J. M. 2017. Active Nerve Regeneration with Failed Target Reinnervation Drives Persistent Neuropathic Pain eNeuro, 4 1 , 14-22Zhang, J.-M. 2017. Neuron-glia interactions in pain Transl Perioper & Pain Med, 2 3 , 14-22Chen, S.; Xie, W.; Strong, J. A.; Jiang, J.; Zhang, J. M. 2016. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats Eur J Pain, 20 7 , 1044-57Ibrahim, S.I.A.; Strong, J.A.; Zhang, J-M 2016. Mineralocorticoid receptor, a promising target for improving management of low back pain by epidural steroid injections (review) J Anesth Perioper Med, 3 33 , 177-184Xie, W.; Chen, S.; Strong, J. A.; Li, A. L.; Lewkowich, I. P.; Zhang, J. M. 2016. Localized sympathectomy reduces mechanical hypersensitivity by restoring normal immune homeostasis in rat models of inflammatory pain J Neurosci, 36 33 , 8712-25Xie, W.; Tan, Z. Y.; Barbosa, C.; Strong, J. A.; Cummins, T. R.; Zhang, J. M. 2016. Upregulation of the sodium channel NaVbeta4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation Pain, 157 4 , 879-891Barbosa, C.; Tan, Z. Y.; Wang, R.; Xie, W.; Strong, J. A.; Patel, R. R.; Vasko, M. R.; Zhang, J. M.; Cummins, T. R. 2015. Navbeta4 regulates fast resurgent sodium currents and excitability in sensory neurons Mol Pain, 11 7 , 60Chen, S.; Zhang, J.-M. 2015. Progress in sympathetically-mediated pathological pain (review) J Anesth Perioper Med, 2 7 , 216-225Xie, W.; Strong, J. A.; Zhang, J. M. 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain Neuroscience, 291 7 , 317-30Ye, L.; Xie, W.; Strong, J. A.; Zhang, J. M. 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats Anesthesiology, 121 3 , 632-43Strong, J. A.; Xie, W.; Bataille, F. J.; Zhang, J. M. 2013. Preclinical studies of low back pain Mol Pain, 9 8 , 17Xie, W.; Strong, J. A.; Ye, L.; Mao, J. X.; Zhang, J. M. 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia Pain, 154 8 , 1170-80Dong, F.; Du, Y. R.; Xie, W.; Strong, J. A.; He, X. J.; Zhang, J. M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neurosci Bull, 28 2 , 155-64Dong, F.; Xie, W.; Strong, J. A.; Zhang, J. M. 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro Anesthesiology, 117 5 , 1102-12Li, C.; Chi, X. X.; Xie, W.; Strong, J. A.; Zhang, J. M.; Nicol, G. D. 2012. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J Neurophysiol, 108 5 , 1473-83Strong, J. A.; Xie, W.; Coyle, D. E.; Zhang, J. M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain PLoS One, 7 7 , e40779Xie, W.; Strong, J. A.; Kays, J.; Nicol, G. D.; Zhang, J. M. 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neurosci Lett, 515 1 , 61-5Xie, W.; Strong, J. A.; Kim, D.; Shahrestani, S.; Zhang, J. M. 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion Neuroscience, 206 8 , 212-23Du, Y. R.; Xiao, Y.; Lu, Z. M.; Ding, J.; Xie, F.; Fu, H.; Wang, Y.; Strong, J. A.; Zhang, J. M.; Chen, J. 2011. Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways Biochem Biophys Res Commun, 408 1 , 32-7Li, J. Y.; Xie, W.; Strong, J. A.; Guo, Q. L.; Zhang, J. M. 2011. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain Reg Anesth Pain Med, 36 1 , 56-62Xie, W.; Strong, J. A.; Mao, J.; Zhang, J. M. 2011. Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse Mol Pain, 7 2 , 53Xie, W.; Strong, J. A.; Zhang, J. M. 2010. Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion Pain, 151 2 , 447-459Jones, W. K.; Fan, G. C.; Liao, S.; Zhang, J. M.; Wang, Y.; Weintraub, N. L.; Kranias, E. G.; Schultz, J. E.; Lorenz, J.; Ren, X. 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling Circulation, 120 11 Suppl , S1-9Li, J.; Xie, W.; Zhang, J. M.; Baccei, M. L. 2009. Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-alpha Mol Pain, 5 4 , 10Xie, W.; Strong, J. A.; Zhang, J. M. 2009. Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models Neuroscience, 160 4 , 847-57Yang, R. H.; Strong, J. A.; Zhang, J. M. 2009. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons Mol Pain, 5 2 , 26Liu, B. G.; Dobretsov, M.; Stimers, J. R.; Zhang, J. M. 2008. Tumor Necrosis Factor-alpha Suppresses Activation of Sustained Potassium Currents in Rat Small Diameter Sensory Neurons Open Pain J, 1 1 , 1Wang, J. G.; Strong, J. A.; Xie, W.; Yang, R. H.; Coyle, D. E.; Wick, D. M.; Dorsey, E. D.; Zhang, J. M. 2008. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons Mol Pain, 4 1 , 38Zhang, J. M.; Munir, M. 2008. Radicular low back pain: what have we learned from recent animal research? Anesthesiology, 108 1 , 5-6Li, H.; Xie, W.; Strong, J. A.; Zhang, J. M. 2007. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain Anesthesiology, 107 3 , 469-77Munir, M. A.; Enany, N.; Zhang, J. M. 2007. Nonopioid analgesics Med Clin North Am, 91 1 , 97-111Munir, M. A.; Enany, N.; Zhang, J. M. 2007. Nonopioid analgesics Anesthesiol Clin, 25 4 , 761-74, viWang, J. G.; Strong, J. A.; Xie, W.; Zhang, J. M. 2007. Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons Anesthesiology, 107 2 , 322-32Xie, W.; Strong, J. A.; Li, H.; Zhang, J. M. 2007. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block J Neurophysiol, 97 1 , 492-502Ackerman, W. E., 3rd; Zhang, J. M. 2006. Serum hs-CRP as a useful marker for predicting the efficacy of lumbar epidural steroid injections on pain relief in patients with lumbar disc herniations J Ky Med Assoc, 104 7 , 295-9Ackerman, W. E.; Zhang, J. M. 2006. Efficacy of stellate ganglion blockade for the management of type 1 complex regional pain syndrome South Med J, 99 10 , 1084-8Ackerman, W.E.; Zhang, J.-M.; Munir, M.A. 2006. Assessment of laser Doppler imaging for the diagnosis of complex regional pain syndrome J. Neuropathic Pain & Symptom Palliation, 1 4 , 13-20Xie, W. R.; Deng, H.; Li, H.; Bowen, T. L.; Strong, J. A.; Zhang, J. M. 2006. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia Neuroscience, 142 3 , 809-22Chien, S. Q.; Li, C.; Li, H.; Xie, W.; Pablo, C. S.; Zhang, J. M. 2005. Sympathetic Fiber Sprouting in Chronically Compressed Dorsal Root Ganglia Without Peripheral Axotomy J Neuropathic Pain Symptom Palliation, 1 1 , 19-23Xie, W.; Strong, J. A.; Meij, J. T. A.; Zhang, J. M.; Yu, L. 2005. Neuropathic pain: early spontaneous afferent activity is the trigger Pain, 116 3 , 243-256Ackerman, W. E.; Munir, M. A.; Zhang, J. M.; Ghaleb, A. 2004. Are diagnostic lumbar facet injections influenced by pain of muscular origin? Pain Pract, 4 4 , 286-91Dupont-Versteegden, E. E.; Houle, J. D.; Dennis, R. A.; Zhang, J.; Knox, M.; Wagoner, G.; Peterson, C. A. 2004. Exercise-induced gene expression in soleus muscle is dependent on time after spinal cord injury in rats Muscle Nerve, 29 1 , 73-81Li, A. H.; Zhang, J. M.; Xie, Y. K. 2004. Human acupuncture points mapped in rats are associated with excitable muscle/skin-nerve complexes with enriched nerve endings Brain Res, 1012 1-2 , 154-9Munir, M. A.; Zhang, J.; Ahmad, M. 2004. A modified needle-inside-needle technique for the ganglion impar block Can J Anaesth, 51 9 , 915-7Simone, D. A.; Zhang, X.; Li, J.; Zhang, J. M.; Honda, C. N.; LaMotte, R. H.; Giesler, G. J., Jr. 2004. Comparison of responses of primate spinothalamic tract neurons to pruritic and algogenic stimuli J Neurophysiol, 91 1 , 213-22Zhang, J. M.; Li, H.; Munir, M. A. 2004. Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine Pain, 109 1-2 , 143-9Dobretsov, M.; Hastings, S. L.; Romanovsky, D.; Stimers, J. R.; Zhang, J. M. 2003. Mechanical hyperalgesia in rat models of systemic and local hyperglycemia Brain Res, 960 1-2 , 174-83Munir, M. A.; Jaffar, M.; Arshad, M.; Akhter, M. S.; Zhang, J. 2003. Reduced duration of muscle relaxation with rocuronium in a normocalcemic hyperparathyroid patient Can J Anaesth, 50 6 , 558-61Song, X. J.; Zhang, J. M.; Hu, S. J.; LaMotte, R. H. 2003. Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators Pain, 104 3 , 701-709Homma, Y.; Brull, S. J.; Zhang, J. M. 2002. A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat Pain, 95 3 , 239-246Li, H.; Liu, B. G.; Dobretsov, M.; Brull, S. J.; Zhang, J. M. 2002. Thermosensitivity of large primary sensory neurons Brain Res, 926 1-2 , 18-26Liu, B.; Li, H.; Brull, S. J.; Zhang, J. M. 2002. Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia J Neurophysiol, 88 3 , 1393-9Zhang, J. M.; Li, H.; Liu, B.; Brull, S. J. 2002. Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons J Neurophysiol, 88 3 , 1387-92Dobretsov, M.; Hastings, S. L.; Stimers, J. R.; Zhang, J. M. 2001. Mechanical hyperalgesia in rats with chronic perfusion of lumbar dorsal root ganglion with hyperglycemic solution J Neurosci Methods, 110 1-2 , 9-15Hu, S. J.; Song, X. J.; Greenquist, K. W.; Zhang, J. M.; LaMotte, R. H. 2001. Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat Pain, 94 1 , 39-46Liu, B. G.; Zhuang, X. L.; Li, S. T.; Xu, G. H.; Brull, S. J.; Zhang, J. M. 2001. Effects of bupivacaine and ropivacaine on high-voltage-activated calcium currents of the dorsal horn neurons in newborn rats Anesthesiology, 95 1 , 139-43Munir, M. A.; Saleem, M.; Zhang, J. M.; Mancino, A. K. 2001. Case of the month. Aberrant placement of central venous catheter in a thymic vein J Ark Med Soc, 98 4 , 112-4Zhang, J. M.; Homma, Y.; Ackerman, W. E.; Brull, S. J. 2001. Topical application of acidic bupivacaine to the lumbar ganglion induces mechanical hyperalgesia in the rat Anesth Analg, 93 2 , 466-71, 4th contents pageZhang, J. M.; Li, H.; Brull, S. J. 2000. Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat J Neurophysiol, 84 2 , 798-805Atanassoff, P. G.; Brull, S. J.; Zhang, J.; Greenquist, K.; Silverman, D. G.; Lamotte, R. H. 1999. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia Somatosens Mot Res, 16 4 , 291-8Brull, S. J.; Atanassoff, P. G.; Silverman, D. G.; Zhang, J.; Lamotte, R. H. 1999. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia Somatosens Mot Res, 16 4 , 299-303Song, X. J.; Hu, S. J.; Greenquist, K. W.; Zhang, J. M.; LaMotte, R. H. 1999. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia J Neurophysiol, 82 6 , 3347-58Zhang, J. M.; Song, X. J.; LaMotte, R. H. 1999. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion J Neurophysiol, 82 6 , 3359-66Zhang, J. M.; Donnelly, D. F.; LaMotte, R. H. 1998. Patch clamp recording from the intact dorsal root ganglion J Neurosci Methods, 79 1 , 97-103Zhang, J. M.; Donnelly, D. F.; Song, X. J.; Lamotte, R. H. 1997. Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons J Neurophysiol, 78 5 , 2790-4Zhang, J. M.; Song, X. J.; LaMotte, R. H. 1997. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion Pain, 72 1-2 , 51-7LaMotte, R. H.; Zhang, J. M.; Petersen, M. 1996. Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat Prog Brain Res, 110 2-3 , 105-11Petersen, M.; Zhang, J.; Zhang, J. M.; LaMotte, R. H. 1996. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction Pain, 67 2-3 , 391-7Xie, Y.; Zhang, J.; Petersen, M.; LaMotte, R. H. 1995. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat J Neurophysiol, 73 5 , 1811-20Zhang, J. 1992. [The role of substance P in the modulation of myotension in paralyzed limbs after spinal transsection on rats] Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 14 6 , 413-8
Research InterestsPhysiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain
Peer Reviewed Publications Qualls, K. A.; Xie, W.; Zhang, J.; Luckemeyer, D. D.; Lackey, S. V.; Strong, J. A.; Zhang, J. M. 2024. Mineralocorticoid Receptor Antagonism Reduces Inflammatory Pain Measures in Mice Independent of the Receptors on Sensory Neurons Neuroscience, 541 , 64-76Silveira Prudente, A.; Hoon Lee, S.; Roh, J.; Luckemeyer, D. D.; Cohen, C. F.; Pertin, M.; Park, C. K.; Suter, M. R.; Decosterd, I.; Zhang, J. M.; Ji, R. R.; Berta, T. 2024. Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice Brain Behav Immun, 117 , 51-65Berta, T.; Strong, J. A.; Zhang, J. M.; Ji, R. R. 2023. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update Expert Opin Ther Targets, 27 8 , 665-678Luckemeyer, D. D.; Xie, W.; Prudente, A. S.; Qualls, K. A.; Tonello, R.; Strong, J. A.; Berta, T.; Zhang, J. M. 2023. The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor beta in a Mouse Model of Radiculopathy Neurosci Bull, 39 9 , 1363-1374Tonello, R.; Silveira Prudente, A.; Hoon Lee, S.; Faith Cohen, C.; Xie, W.; Paranjpe, A.; Roh, J.; Park, C. K.; Chung, G.; Strong, J. A.; Zhang, J. M.; Berta, T. 2023. Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain Brain Behav Immun, 113 , 401-414Zheng, Q.; Xie, W.; Luckemeyer, D. D.; Lay, M.; Wang, X. W.; Dong, X.; Limjunyawong, N.; Ye, Y.; Zhou, F. Q.; Strong, J. A.; Zhang, J. M.; Dong, X. 2022. Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain Neuron, 110 2 , 209-220 e6Zhu, X.; Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2022. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model Pain, 163 1 , e106-e120Zhang, L.; Xie, W.; Zhang, J.; Shanahan, H.; Tonello, R.; Lee, S. H.; Strong, J. A.; Berta, T.; Zhang, J. M. 2021. Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy Brain Behav Immun, 91 2 , 556-567Ibrahim, S. I. A.; Strong, J. A.; Qualls, K. A.; Ulrich-Lai, Y. M.; Zhang, J. M. 2020. Differential Regulation of the Glucocorticoid Receptor in a Rat Model of Inflammatory Pain Anesth Analg, 131 1 , 298-306Tonello, R.; Xie, W.; Lee, S. H.; Wang, M.; Liu, X.; Strong, J. A.; Zhang, J. M.; Berta, T. 2020. Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice Anesthesiology, 132 6 , 1540-1553Xie, W.; Strong, J. A.; Zhang, J. M. 2020. Localized sympathectomy reduces peripheral nerve regeneration and pain behaviors in 2 rat neuropathic pain models Pain, 161 8 , 1925-1936Dai, J.; Ding, Z.; Zhang, J.; Xu, W.; Guo, Q.; Zou, W.; Xiong, Y.; Weng, Y.; Yang, Y.; Chen, S.; Zhang, J. M.; Song, Z. 2019. Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus Anesth Analg, 129 6 , 1733-1741Ren, X.; Roessler, A. E.; Lynch, T. L. th; Haar, L.; Mallick, F.; Lui, Y.; Tranter, M.; Ren, M. H.; Xie, W. R.; Fan, G. C.; Zhang, J. M.; Kranias, E. G.; Anjak, A.; Koch, S.; Jiang, M.; Miao, Q.; Wang, Y.; Cohen, A.; Rubinstein, J.; Weintraub, N. L.; Jones, W. K. 2019. Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time Am J Physiol Heart Circ Physiol, 316 3 , H543-H553Schappacher, K. A.; Xie, W.; Zhang, J. M.; Baccei, M. L. 2019. Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence Pain, 160 3 , 645-657Xiao, Y.; Barbosa, C.; Pei, Z.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2019. Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies J Neurosci, 39 8 , 1539-1550Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2019. Role of Na(V)1.6 and Na(V)beta4 Sodium Channel Subunits in a Rat Model of Low Back Pain Induced by Compression of the Dorsal Root Ganglia Neuroscience, 402 1 , 51-65Bang, S.; Yoo, J.; Gong, X.; Liu, D.; Han, Q.; Luo, X.; Chang, W.; Chen, G.; Im, S. T.; Kim, Y. H.; Strong, J. A.; Zhang, M. Z.; Zhang, J. M.; Lee, S. Y.; Ji, R. R. 2018. Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies Neurosci Bull, 34 1 , 22-41Ibrahim, S. I. A.; Xie, W.; Strong, J. A.; Tonello, R.; Berta, T.; Zhang, J. M. 2018. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain Front Cell Neurosci, 12 1 , 453Li, A. L.; Zhang, J. D.; Xie, W.; Strong, J. A.; Zhang, J. M. 2018. Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models Neurosci Bull, 34 1 , 85-97Liu, Z.; Chen, S.; Qiu, C.; Sun, Y.; Li, W.; Jiang, J.; Zhang, J. M. 2018. Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats Front Cell Neurosci, 12 5 , 495Lu, G. F.; Zhang, J. M.; An, J. X.; Oian, X. Y.; Wang, Y.; Lin, S. Y.; Williams, J. P. 2018. Enhanced Pain Sensitivity with Systemic Ultrastructural Changes of the Nervous Systems after Cobra Venom Injection is Reversed by Electroacupuncture Treatment Pain Physician, 21 5 , E509-E521Song, Z.; Xie, W.; Strong, J. A.; Berta, T.; Ulrich-Lai, Y. M.; Guo, Q.; Zhang, J. M. 2018. High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner Pain, 159 9 , 1731-1741Xie, W.; Strong, J.A.; Zhang, J.-M. 2018. SCN8A (Nav1.6): gate to chronic pain (review) J Anesth Perioper Med, 5 6 , 293-305Barbosa, C.; Xiao, Y.; Johnson, A. J.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2017. FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons Pflugers Arch, 469 2 , 195-212Ding, Z.; Xu, W.; Zhang, J.; Zou, W.; Guo, Q.; Huang, C.; Liu, C.; Zhong, T.; Zhang, J. M.; Song, Z. 2017. Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain Int J Cancer, 140 2 , 411-422Song, Z.; Xie, W.; Chen, S.; Strong, J. A.; Print, M. S.; Wang, J. I.; Shareef, A. F.; Ulrich-Lai, Y. M.; Zhang, J. M. 2017. High-fat diet increases pain behaviors in rats with or without obesity Sci Rep, 7 1 , 10350Xie, W.; Strong, J. A.; Zhang, J. M. 2017. Active Nerve Regeneration with Failed Target Reinnervation Drives Persistent Neuropathic Pain eNeuro, 4 1 , 14-22Zhang, J.-M. 2017. Neuron-glia interactions in pain Transl Perioper & Pain Med, 2 3 , 14-22Chen, S.; Xie, W.; Strong, J. A.; Jiang, J.; Zhang, J. M. 2016. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats Eur J Pain, 20 7 , 1044-57Ibrahim, S.I.A.; Strong, J.A.; Zhang, J-M 2016. Mineralocorticoid receptor, a promising target for improving management of low back pain by epidural steroid injections (review) J Anesth Perioper Med, 3 33 , 177-184Xie, W.; Chen, S.; Strong, J. A.; Li, A. L.; Lewkowich, I. P.; Zhang, J. M. 2016. Localized sympathectomy reduces mechanical hypersensitivity by restoring normal immune homeostasis in rat models of inflammatory pain J Neurosci, 36 33 , 8712-25Xie, W.; Tan, Z. Y.; Barbosa, C.; Strong, J. A.; Cummins, T. R.; Zhang, J. M. 2016. Upregulation of the sodium channel NaVbeta4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation Pain, 157 4 , 879-891Barbosa, C.; Tan, Z. Y.; Wang, R.; Xie, W.; Strong, J. A.; Patel, R. R.; Vasko, M. R.; Zhang, J. M.; Cummins, T. R. 2015. Navbeta4 regulates fast resurgent sodium currents and excitability in sensory neurons Mol Pain, 11 7 , 60Chen, S.; Zhang, J.-M. 2015. Progress in sympathetically-mediated pathological pain (review) J Anesth Perioper Med, 2 7 , 216-225Xie, W.; Strong, J. A.; Zhang, J. M. 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain Neuroscience, 291 7 , 317-30Ye, L.; Xie, W.; Strong, J. A.; Zhang, J. M. 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats Anesthesiology, 121 3 , 632-43Strong, J. A.; Xie, W.; Bataille, F. J.; Zhang, J. M. 2013. Preclinical studies of low back pain Mol Pain, 9 8 , 17Xie, W.; Strong, J. A.; Ye, L.; Mao, J. X.; Zhang, J. M. 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia Pain, 154 8 , 1170-80Dong, F.; Du, Y. R.; Xie, W.; Strong, J. A.; He, X. J.; Zhang, J. M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neurosci Bull, 28 2 , 155-64Dong, F.; Xie, W.; Strong, J. A.; Zhang, J. M. 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro Anesthesiology, 117 5 , 1102-12Li, C.; Chi, X. X.; Xie, W.; Strong, J. A.; Zhang, J. M.; Nicol, G. D. 2012. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor J Neurophysiol, 108 5 , 1473-83Strong, J. A.; Xie, W.; Coyle, D. E.; Zhang, J. M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain PLoS One, 7 7 , e40779Xie, W.; Strong, J. A.; Kays, J.; Nicol, G. D.; Zhang, J. M. 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neurosci Lett, 515 1 , 61-5Xie, W.; Strong, J. A.; Kim, D.; Shahrestani, S.; Zhang, J. M. 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion Neuroscience, 206 8 , 212-23Du, Y. R.; Xiao, Y.; Lu, Z. M.; Ding, J.; Xie, F.; Fu, H.; Wang, Y.; Strong, J. A.; Zhang, J. M.; Chen, J. 2011. Melittin activates TRPV1 receptors in primary nociceptive sensory neurons via the phospholipase A2 cascade pathways Biochem Biophys Res Commun, 408 1 , 32-7Li, J. Y.; Xie, W.; Strong, J. A.; Guo, Q. L.; Zhang, J. M. 2011. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain Reg Anesth Pain Med, 36 1 , 56-62Xie, W.; Strong, J. 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Qualls, K. A.; Xie, W.; Zhang, J.; Luckemeyer, D. D.; Lackey, S. V.; Strong, J. A.; Zhang, J. M. 2024. Mineralocorticoid Receptor Antagonism Reduces Inflammatory Pain Measures in Mice Independent of the Receptors on Sensory Neurons Neuroscience, 541 , 64-76Silveira Prudente, A.; Hoon Lee, S.; Roh, J.; Luckemeyer, D. D.; Cohen, C. F.; Pertin, M.; Park, C. K.; Suter, M. R.; Decosterd, I.; Zhang, J. M.; Ji, R. R.; Berta, T. 2024. Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female mice Brain Behav Immun, 117 , 51-65Berta, T.; Strong, J. A.; Zhang, J. M.; Ji, R. R. 2023. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update Expert Opin Ther Targets, 27 8 , 665-678Luckemeyer, D. D.; Xie, W.; Prudente, A. S.; Qualls, K. A.; Tonello, R.; Strong, J. A.; Berta, T.; Zhang, J. M. 2023. The Antinociceptive Effect of Sympathetic Block is Mediated by Transforming Growth Factor beta in a Mouse Model of Radiculopathy Neurosci Bull, 39 9 , 1363-1374Tonello, R.; Silveira Prudente, A.; Hoon Lee, S.; Faith Cohen, C.; Xie, W.; Paranjpe, A.; Roh, J.; Park, C. K.; Chung, G.; Strong, J. A.; Zhang, J. M.; Berta, T. 2023. Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain Brain Behav Immun, 113 , 401-414Zheng, Q.; Xie, W.; Luckemeyer, D. D.; Lay, M.; Wang, X. W.; Dong, X.; Limjunyawong, N.; Ye, Y.; Zhou, F. Q.; Strong, J. A.; Zhang, J. M.; Dong, X. 2022. Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain Neuron, 110 2 , 209-220 e6Zhu, X.; Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2022. Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model Pain, 163 1 , e106-e120Zhang, L.; Xie, W.; Zhang, J.; Shanahan, H.; Tonello, R.; Lee, S. H.; Strong, J. A.; Berta, T.; Zhang, J. M. 2021. Key role of CCR2-expressing macrophages in a mouse model of low back pain and radiculopathy Brain Behav Immun, 91 2 , 556-567Ibrahim, S. I. A.; Strong, J. A.; Qualls, K. A.; Ulrich-Lai, Y. M.; Zhang, J. M. 2020. Differential Regulation of the Glucocorticoid Receptor in a Rat Model of Inflammatory Pain Anesth Analg, 131 1 , 298-306Tonello, R.; Xie, W.; Lee, S. H.; Wang, M.; Liu, X.; Strong, J. A.; Zhang, J. M.; Berta, T. 2020. Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice Anesthesiology, 132 6 , 1540-1553Xie, W.; Strong, J. A.; Zhang, J. M. 2020. Localized sympathectomy reduces peripheral nerve regeneration and pain behaviors in 2 rat neuropathic pain models Pain, 161 8 , 1925-1936Dai, J.; Ding, Z.; Zhang, J.; Xu, W.; Guo, Q.; Zou, W.; Xiong, Y.; Weng, Y.; Yang, Y.; Chen, S.; Zhang, J. M.; Song, Z. 2019. Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus Anesth Analg, 129 6 , 1733-1741Ren, X.; Roessler, A. E.; Lynch, T. L. th; Haar, L.; Mallick, F.; Lui, Y.; Tranter, M.; Ren, M. H.; Xie, W. R.; Fan, G. C.; Zhang, J. M.; Kranias, E. G.; Anjak, A.; Koch, S.; Jiang, M.; Miao, Q.; Wang, Y.; Cohen, A.; Rubinstein, J.; Weintraub, N. L.; Jones, W. K. 2019. Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time Am J Physiol Heart Circ Physiol, 316 3 , H543-H553Schappacher, K. A.; Xie, W.; Zhang, J. M.; Baccei, M. L. 2019. Neonatal vincristine administration modulates intrinsic neuronal excitability in the rat dorsal root ganglion and spinal dorsal horn during adolescence Pain, 160 3 , 645-657Xiao, Y.; Barbosa, C.; Pei, Z.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2019. Increased Resurgent Sodium Currents in Nav1.8 Contribute to Nociceptive Sensory Neuron Hyperexcitability Associated with Peripheral Neuropathies J Neurosci, 39 8 , 1539-1550Xie, W.; Zhang, J.; Strong, J. A.; Zhang, J. M. 2019. Role of Na(V)1.6 and Na(V)beta4 Sodium Channel Subunits in a Rat Model of Low Back Pain Induced by Compression of the Dorsal Root Ganglia Neuroscience, 402 1 , 51-65Bang, S.; Yoo, J.; Gong, X.; Liu, D.; Han, Q.; Luo, X.; Chang, W.; Chen, G.; Im, S. T.; Kim, Y. H.; Strong, J. A.; Zhang, M. Z.; Zhang, J. M.; Lee, S. Y.; Ji, R. R. 2018. Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies Neurosci Bull, 34 1 , 22-41Ibrahim, S. I. A.; Xie, W.; Strong, J. A.; Tonello, R.; Berta, T.; Zhang, J. M. 2018. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain Front Cell Neurosci, 12 1 , 453Li, A. L.; Zhang, J. D.; Xie, W.; Strong, J. A.; Zhang, J. M. 2018. Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models Neurosci Bull, 34 1 , 85-97Liu, Z.; Chen, S.; Qiu, C.; Sun, Y.; Li, W.; Jiang, J.; Zhang, J. M. 2018. Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats Front Cell Neurosci, 12 5 , 495Lu, G. F.; Zhang, J. M.; An, J. X.; Oian, X. Y.; Wang, Y.; Lin, S. Y.; Williams, J. P. 2018. Enhanced Pain Sensitivity with Systemic Ultrastructural Changes of the Nervous Systems after Cobra Venom Injection is Reversed by Electroacupuncture Treatment Pain Physician, 21 5 , E509-E521Song, Z.; Xie, W.; Strong, J. A.; Berta, T.; Ulrich-Lai, Y. M.; Guo, Q.; Zhang, J. M. 2018. High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner Pain, 159 9 , 1731-1741Xie, W.; Strong, J.A.; Zhang, J.-M. 2018. SCN8A (Nav1.6): gate to chronic pain (review) J Anesth Perioper Med, 5 6 , 293-305Barbosa, C.; Xiao, Y.; Johnson, A. J.; Xie, W.; Strong, J. A.; Zhang, J. M.; Cummins, T. R. 2017. FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons Pflugers Arch, 469 2 , 195-212Ding, Z.; Xu, W.; Zhang, J.; Zou, W.; Guo, Q.; Huang, C.; Liu, C.; Zhong, T.; Zhang, J. M.; Song, Z. 2017. 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