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Photo of  Judy Strong, PhD

Judy Strong, PhD

Research Associate Professor

Research Interests

Cellular and molecular basis of chronic pain, Function and regulation of receptors and ion channels, Functional genetics
 

Education/Credentials
  • B.S.: Brandeis Univ.
  • Ph.D.: Yale Univ.
Contact Information
  • Medical Sciences Building
  • Room MSB 3257
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-4194
  • Fax 513-558-0995
  • Email judith.strong@uc.edu

Peer Reviewed Publications

Bang, Sangsu; Yoo, Jiho; Gong, Xingrui; Liu, Di; Han, Qingjian; Luo, Xin; Chang, Wonseok; Chen, Gang; Im, Sang-Taek; Kim, Yong Ho; Strong, Judith A; Zhang, Ma-Zhong; Zhang, Jun-Ming; Lee, Seok-Yong; Ji, Ru-Rong 2018. Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. Neuroscience bulletin, 34 1, 22-41

Josephs, Sean A; Lemmink, Gretchen A; Strong, Judith A; Barry, Cassandra L; Hurford, William E 2018. Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies at a University Medical Center. Anesthesia and analgesia, 126 1, 150-160

Li, Ai-Ling; Zhang, Jing-Dong; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2018. Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models. Neuroscience bulletin, 34 1, 85-97

Barbosa, Cindy; Xiao, Yucheng; Johnson, Andrew J; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming; Cummins, Theodore R 2017. FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons. Pflugers Archiv : European journal of physiology, 469 2, 195-212

Song, Zongbin; Xie, Wenrui; Chen, Sisi; Strong, Judith A; Print, Mason S; Wang, Joy I; Shareef, Aleeya F; Ulrich-Lai, Yvonne M; Zhang, Jun-Ming 2017. High-fat diet increases pain behaviors in rats with or without obesity. Scientific reports, 7 1, 10350

Chen, S; Xie, W; Strong, J A; Jiang, J; Zhang, J-M 2016. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats. European journal of pain (London, England), 20 7, 1044-57

Ibrahim, Shaimaa I A; Strong, Judith A; Zhang, Jun-Ming 2016. Mineralocorticoid Receptor, A Promising Target for Improving Management of Low Back Pain by Epidural Steroid Injections. Journal of anesthesia and perioperative medicine, 3 4, 177-184

Xie, W. Tan, Z., Barbosa, C., Strong, J. A., Cummins, T. R., and Zhang, J.-M 2016. Upregulation of the sodium channel NaVĪ²4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local DRG inflammation Pain , 157 , 879-91

Xie, W., Chen, S., Strong, J. A., Li, A.-L., Lewkowich, I. P. and Zhang, J.-M. 2016. Localized sympathectomy reduces mechanical hypersensitivity by restoring normal immune homeostasis in rat models of inflammatory pain J. Neurosci , 36 , 8712-25

Xie, Wenrui; Chen, Sisi; Strong, Judith A; Li, Ai-Ling; Lewkowich, Ian P; Zhang, Jun-Ming 2016. Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 33, 8712-25

Xie, Wenrui; Tan, Zhi-Yong; Barbosa, Cindy; Strong, Judith A; Cummins, Theodore R; Zhang, Jun-Ming 2016. Upregulation of the sodium channel NaV?4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation. Pain, 157 4, 879-91

Barbosa, C., Tan, Z.Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M. R., Zhang, J.-M and Cummins, T. R. 2015. NavĪ²4 regulates fast resurgent sodium currents and excitability in sensory neurons. Molecular Pain, 11 , 60

Barbosa, Cindy; Tan, Zhi-Yong; Wang, Ruizhong; Xie, Wenrui; Strong, Judith A; Patel, Reesha R; Vasko, Michael R; Zhang, Jun-Ming; Cummins, Theodore R 2015. Nav?4 regulates fast resurgent sodium currents and excitability in sensory neurons. Molecular pain, 11 , 60

Chen, S., Xie, W., Strong, J. A., Jiang, J. and Zhang, J.-M 2015. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats European Journal of Pain, 20 , 1044-57

Wright, Natasha E; Strong, Judith A; Gilbart, Erika R; Shollenbarger, Skyler G; Lisdahl, Krista M 2015. 5-HTTLPR Genotype Moderates the Effects of Past Ecstasy Use on Verbal Memory Performance in Adolescent and Emerging Adults: A Pilot Study. PloS one, 10 7, e0134708

Xie, W., Strong, J.A. and Zhang, J.-M. 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience, 291 , 317-330

Xie, W; Strong, J A; Zhang, J-M 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience, 291 , 317-30

Ye, L., Xie, W., Strong, J.A. and Zhang, J.-M. 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats Anesthesiology, 121 , 632-43

Ye, Ling; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats. Anesthesiology, 121 3, 632-43

Strong, Judith A; Xie, Wenrui; Bataille, Feguens J; Zhang, Jun-Ming 2013. Preclinical studies of low back pain. Molecular pain, 9 , 17

Xie, W., Strong, J.A., Ye, L., Mao, J.-X., and Zhang, J.-M 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia Pain, 154 , 1170-1180

Xie, Wenrui; Strong, Judith A; Ye, Ling; Mao, Ju-Xian; Zhang, Jun-Ming 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia. Pain, 154 8, 1170-80

Dong, F., Du, Y.-R., Xie, W., Strong, J.A., He, X.-J., and Zhang, J.-M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neuroscience Bulletin , 28 , 155-164

Dong, F., Xie, W., Strong, J.A., and Zhang, J.-M 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small diameter sensory neurons from local inflamed DRG in vitro. Anesthesiology, 117 , 1102-12

Dong, F.; Du, Y.-R.; Xie, W.; Strong, J. A.; He, X.-J.; Zhang, J.-M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neurosci Bull, 28 7 , 155-164

Dong, Fei; Du, Yi-Ru; Xie, Wenrui; Strong, Judith A; He, Xi-Jing; Zhang, Jun-Ming 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC. Neuroscience bulletin, 28 2, 155-64

Dong, Fei; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro. Anesthesiology, 117 5, 1102-12

Strong, J. A.; Xie, W; Coyle, D.E.; Zhang, J. M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain PLoS One, 7 7 , e40779

Strong, J.A., Xie, W., Coyle, D.E., and Zhang, J.-M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain. PloS One, , e40779

Strong, Judith A; Xie, Wenrui; Coyle, Dennis E; Zhang, Jun-Ming 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain. PloS one, 7 7, e40779

Xie, W., Strong, J.A., Kays, J., Nicol, G.D. and Zhang, J-M 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neuroscience Letters , 515 , 61-65

Xie, W.; Strong, J. A.; Kim, D.; Shahrestani, S.; Zhang, J. M. 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion Neuroscience, 206 7 , 212-223

Xie, W.; Strong, J. A.; Kays, J.; Nicol, G. D.; Zhang, J. M. 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neurosci Lett, 515 1 , 61-5

Xie, W; Strong, J A; Kim, D; Shahrestani, S; Zhang, J-M 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion. Neuroscience, 206 , 212-23

Xie, Wenrui; Strong, Judith A; Kays, Joanne; Nicol, Grant D; Zhang, Jun-Ming 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion. Neuroscience letters, 515 1, 61-5

Li, J. Y.; Xie, W.; Strong, J. A.; Guo, Q. L.; Zhang, J. M. 2011. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain Reg Anesth Pain Med, 36 1 , 56-62

Xie, W.; Strong, J. A.; Mao, J.; Zhang, J. M. 2011. Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse Mol Pain, 7 7 , 53

Xie, Wenrui; Strong, Judith A; Mao, Juxian; Zhang, Jun-Ming 2011. Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse. Molecular pain, 7 , 53

Thompson, Rachel D; Heffner, Jaimee L; Strong, Judith A; Blom, Thomas J; Anthenelli, Robert M 2010. Relationship between the serotonin transporter polymorphism and obsessive-compulsive alcohol craving in alcohol-dependent adults: a pilot study. Alcohol (Fayetteville, N.Y.), 44 5, 401-6

Xie, W.; Strong, J. A.; Zhang, J. M. 2010. Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion Pain, 151 2 , 447-59

Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2010. Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion. Pain, 151 2, 447-59

Xie, W.; Strong, J. A.; Zhang, J. M. 2009. Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models Neuroscience, 160 4 , 847-857

Xie, W; Strong, J A; Zhang, J-M 2009. Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models. Neuroscience, 160 4, 847-57

Yang, R. H.; Strong, J. A.; Zhang, J. M. 2009. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons Mol Pain, 5 2 , 26

Yang, Rui-Hua; Strong, Judith A; Zhang, Jun-Ming 2009. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Molecular pain, 5 , 26

Wang, J. G.; Strong, J. A.; Xie, W.; Yang, R. H.; Coyle, D. E.; Wick, D. M.; Dorsey, E. D.; Zhang, J. M. 2008. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons Mol Pain, 4 5 , 38

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Yang, Rui-Hua; Coyle, Dennis E; Wick, Dayna M; Dorsey, Ericka D; Zhang, Jun-Ming 2008. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Molecular pain, 4 , 38

Xie, W.; Strong, J. A.; Zhang, J-M 2008. Sympathetic nerve sprouting is closely related to the pattern of spontaneous activity in axotomized DRG neurons Sheng Li Xue Bao, 759 5 , 2

Zhang, J. M.; Strong, J. A. 2008. Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain Sheng Li Xue Bao, 60 5 , 617-27

Zhang, Jun-Ming; Strong, Judith A 2008. Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain. Sheng li xue bao : [Acta physiologica Sinica], 60 5, 617-27

Li, H.; Xie, W.; Strong, J. A.; Zhang, J.-M. 2007. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain Anesthesiology, 107 3 , 469-77

Li, Huiqing; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2007. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain. Anesthesiology, 107 3, 469-77

Strong, Judith Ann 2007. Genetics of pain: lessons for future studies. International anesthesiology clinics, 45 2, 13-25

Wang, J. G.; Strong, J. A.; Xie, W.; Zhang, J. -M. 2007. Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons Anesthesiology, 107 2 , 322-32

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Zhang, Jun-Ming 2007. Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons. Anesthesiology, 107 2, 322-32

Xie, W.; Strong, J. A.; Li, H.; Zhang, J. -M. 2007. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block J Neurophysiol, 97 1 , 492-502

Xie, Wenrui; Strong, Judith Ann; Li, Huiqing; Zhang, Jun-Ming 2007. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block. Journal of neurophysiology, 97 1, 492-502

Strong, Judith A; Dalvi, Arif; Revilla, Fredy J; Sahay, Alok; Samaha, Frederick J; Welge, Jeffrey A; Gong, Jianhua; Gartner, Maureen; Yue, Xia; Yu, Lei 2006. Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 21 5, 654-9

Wang, J.; Strong, J.A.; Zhang, J.-M. 2006. Localized inflammation alters excitability and ion currents in rat sensory neurons J Neurophysiol, 31 1 , 492-502

Xie, W. R.; Deng, H.; Li, H.; Bowen, T. L.; Strong, J. A.; Zhang, J. -M. 2006. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia Neuroscience, 142 3 , 809-822

Xie, W-R; Deng, H; Li, H; Bowen, T L; Strong, J A; Zhang, J-M 2006. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia. Neuroscience, 142 3, 809-22

Wang, X.; Zhang, Y.; Kong, L.; Xie, Z.; Lin, Z.; Guo, N.; Strong, J. A.; Meij, J. T.; Zhao, Z.; Jing, N.; Yu, L. 2005. RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour Neuroscience, 22 5 , 1090-6

Xie, W.; Strong, J. A.; Meij, J. T.; Zhang, J. -M.; Yu, L. 2005. Neuropathic pain: Early spontaneous afferent activity is the trigger Pain, 116 3 , 243-56

Xie, Wenrui; Strong, Judith A; Meij, Johanna T A; Zhang, Jun-Ming; Yu, Lei 2005. Neuropathic pain: early spontaneous afferent activity is the trigger. Pain, 116 3, 243-56

Zheng, W.; Xie, W.; Zhang, J.; Strong, J. A.; Wang, L.; Yu, L.; Xu, M.; Lu, L. 2003. Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord J Biol Chem, 278 48 , 48321-9

Bond, C.; LaForge, K. S.; Tian, M.; Melia, D.; Zhang, S.; Borg, L.; Gong, J.; Schluger, J.; Strong, J. A.; Leal, S. M.; Tischfield, J. A.; Kreek, M. J.; Yu, L. 1998. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction Proc Natl Acad Sci U S A, 95 16 , 9608-13

Gong, J; Strong, J A; Zhang, S; Yue, X; DeHaven, R N; Daubert, J D; Cassel, J A; Yu, G; Mansson, E; Yu, L 1998. Endomorphins fully activate a cloned human mu opioid receptor. FEBS letters, 439 1-2, 152-6

Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming . Active Nerve Regeneration with Failed Target Reinnervation Drives Persistent Neuropathic Pain. eNeuro, 4 1,

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Department of Anesthesiology

Medical Sciences Building
Room 3502
231 Albert Sabin Way
PO Box 670531
Cincinnati, OH 45267-0531

Mail Location: 0531
Phone: 513-558-2402
Fax: 513-558-0995
Email: mcclanpa@ucmail.uc.edu