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Department of

Anesthesiology

Photo of  Judy Strong, PhD

Judy Strong, PhD

Research Associate Professor

Education/Credentials
  • B.S.: Brandeis Univ.
  • Ph.D.: Yale Univ.

Contact Information
  • Medical Sciences Building
  • Room MSB 3257
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-4194
  • Fax 513-558-0995
  • Email judith.strong@uc.edu

Peer Reviewed Publications

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Bang, Sangsu; Yoo, Jiho; Gong, Xingrui; Liu, Di; Han, Qingjian; Luo, Xin; Chang, Wonseok; Chen, Gang; Im, Sang-Taek; Kim, Yong Ho; Strong, Judith A; Zhang, Ma-Zhong; Zhang, Jun-Ming; Lee, Seok-Yong; Ji, Ru-Rong 2018. Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. Neuroscience bulletin, 34 1, 22-41

Josephs, Sean A; Lemmink, Gretchen A; Strong, Judith A; Barry, Cassandra L; Hurford, William E 2018. Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies at a University Medical Center. Anesthesia and analgesia, 126 1, 150-160

Li, Ai-Ling; Zhang, Jing-Dong; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2018. Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models. Neuroscience bulletin, 34 1, 85-97

Barbosa, Cindy; Xiao, Yucheng; Johnson, Andrew J; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming; Cummins, Theodore R 2017. FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons. Pflugers Archiv : European journal of physiology, 469 2, 195-212

Song, Zongbin; Xie, Wenrui; Chen, Sisi; Strong, Judith A; Print, Mason S; Wang, Joy I; Shareef, Aleeya F; Ulrich-Lai, Yvonne M; Zhang, Jun-Ming 2017. High-fat diet increases pain behaviors in rats with or without obesity. Scientific reports, 7 1, 10350

Chen, S; Xie, W; Strong, J A; Jiang, J; Zhang, J-M 2016. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats. European journal of pain (London, England), 20 7, 1044-57

Ibrahim, Shaimaa I A; Strong, Judith A; Zhang, Jun-Ming 2016. Mineralocorticoid Receptor, A Promising Target for Improving Management of Low Back Pain by Epidural Steroid Injections. Journal of anesthesia and perioperative medicine, 3 4, 177-184

Xie, W. Tan, Z., Barbosa, C., Strong, J. A., Cummins, T. R., and Zhang, J.-M 2016. Upregulation of the sodium channel NaVβ4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local DRG inflammation Pain , 157 , 879-91

Xie, W., Chen, S., Strong, J. A., Li, A.-L., Lewkowich, I. P. and Zhang, J.-M. 2016. Localized sympathectomy reduces mechanical hypersensitivity by restoring normal immune homeostasis in rat models of inflammatory pain J. Neurosci , 36 , 8712-25

Xie, Wenrui; Chen, Sisi; Strong, Judith A; Li, Ai-Ling; Lewkowich, Ian P; Zhang, Jun-Ming 2016. Localized Sympathectomy Reduces Mechanical Hypersensitivity by Restoring Normal Immune Homeostasis in Rat Models of Inflammatory Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 33, 8712-25

Xie, Wenrui; Tan, Zhi-Yong; Barbosa, Cindy; Strong, Judith A; Cummins, Theodore R; Zhang, Jun-Ming 2016. Upregulation of the sodium channel NaV?4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation. Pain, 157 4, 879-91

Barbosa, C., Tan, Z.Y., Wang, R., Xie, W., Strong, J. A., Patel, R. R., Vasko, M. R., Zhang, J.-M and Cummins, T. R. 2015. Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons. Molecular Pain, 11 , 60

Barbosa, Cindy; Tan, Zhi-Yong; Wang, Ruizhong; Xie, Wenrui; Strong, Judith A; Patel, Reesha R; Vasko, Michael R; Zhang, Jun-Ming; Cummins, Theodore R 2015. Nav?4 regulates fast resurgent sodium currents and excitability in sensory neurons. Molecular pain, 11 , 60

Chen, S., Xie, W., Strong, J. A., Jiang, J. and Zhang, J.-M 2015. Sciatic endometriosis induces mechanical hypersensitivity, segmental nerve damage, and robust local inflammation in rats European Journal of Pain, 20 , 1044-57

Wright, Natasha E; Strong, Judith A; Gilbart, Erika R; Shollenbarger, Skyler G; Lisdahl, Krista M 2015. 5-HTTLPR Genotype Moderates the Effects of Past Ecstasy Use on Verbal Memory Performance in Adolescent and Emerging Adults: A Pilot Study. PloS one, 10 7, e0134708

Xie, W., Strong, J.A. and Zhang, J.-M. 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience, 291 , 317-330

Xie, W; Strong, J A; Zhang, J-M 2015. Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain. Neuroscience, 291 , 317-30

Ye, L., Xie, W., Strong, J.A. and Zhang, J.-M. 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats Anesthesiology, 121 , 632-43

Ye, Ling; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2014. Blocking the mineralocorticoid receptor improves effectiveness of steroid treatment for low back pain in rats. Anesthesiology, 121 3, 632-43

Strong, Judith A; Xie, Wenrui; Bataille, Feguens J; Zhang, Jun-Ming 2013. Preclinical studies of low back pain. Molecular pain, 9 , 17

Xie, W., Strong, J.A., Ye, L., Mao, J.-X., and Zhang, J.-M 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia Pain, 154 , 1170-1180

Xie, Wenrui; Strong, Judith A; Ye, Ling; Mao, Ju-Xian; Zhang, Jun-Ming 2013. Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia. Pain, 154 8, 1170-80

Dong, F., Du, Y.-R., Xie, W., Strong, J.A., He, X.-J., and Zhang, J.-M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neuroscience Bulletin , 28 , 155-164

Dong, F., Xie, W., Strong, J.A., and Zhang, J.-M 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small diameter sensory neurons from local inflamed DRG in vitro. Anesthesiology, 117 , 1102-12

Dong, F.; Du, Y.-R.; Xie, W.; Strong, J. A.; He, X.-J.; Zhang, J.-M. 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC Neurosci Bull, 28 7 , 155-164

Dong, Fei; Du, Yi-Ru; Xie, Wenrui; Strong, Judith A; He, Xi-Jing; Zhang, Jun-Ming 2012. Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC. Neuroscience bulletin, 28 2, 155-64

Dong, Fei; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2012. Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro. Anesthesiology, 117 5, 1102-12

Strong, J. A.; Xie, W; Coyle, D.E.; Zhang, J. M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain PLoS One, 7 7 , e40779

Strong, J.A., Xie, W., Coyle, D.E., and Zhang, J.-M. 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain. PloS One, , e40779

Strong, Judith A; Xie, Wenrui; Coyle, Dennis E; Zhang, Jun-Ming 2012. Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain. PloS one, 7 7, e40779

Xie, W., Strong, J.A., Kays, J., Nicol, G.D. and Zhang, J-M 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neuroscience Letters , 515 , 61-65

Xie, W.; Strong, J. A.; Kim, D.; Shahrestani, S.; Zhang, J. M. 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion Neuroscience, 206 7 , 212-223

Xie, W.; Strong, J. A.; Kays, J.; Nicol, G. D.; Zhang, J. M. 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1reduces pain behaviors induced by local inflammation of the rat sensory ganglion Neurosci Lett, 515 1 , 61-5

Xie, W; Strong, J A; Kim, D; Shahrestani, S; Zhang, J-M 2012. Bursting activity in myelinated sensory neurons plays a key role in pain behavior induced by localized inflammation of the rat sensory ganglion. Neuroscience, 206 , 212-23

Xie, Wenrui; Strong, Judith A; Kays, Joanne; Nicol, Grant D; Zhang, Jun-Ming 2012. Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion. Neuroscience letters, 515 1, 61-5

Li, J. Y.; Xie, W.; Strong, J. A.; Guo, Q. L.; Zhang, J. M. 2011. Mechanical hypersensitivity, sympathetic sprouting, and glial activation are attenuated by local injection of corticosteroid near the lumbar ganglion in a rat model of neuropathic pain Reg Anesth Pain Med, 36 1 , 56-62

Xie, W.; Strong, J. A.; Mao, J.; Zhang, J. M. 2011. Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse Mol Pain, 7 7 , 53

Xie, Wenrui; Strong, Judith A; Mao, Juxian; Zhang, Jun-Ming 2011. Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse. Molecular pain, 7 , 53

Thompson, Rachel D; Heffner, Jaimee L; Strong, Judith A; Blom, Thomas J; Anthenelli, Robert M 2010. Relationship between the serotonin transporter polymorphism and obsessive-compulsive alcohol craving in alcohol-dependent adults: a pilot study. Alcohol (Fayetteville, N.Y.), 44 5, 401-6

Xie, W.; Strong, J. A.; Zhang, J. M. 2010. Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion Pain, 151 2 , 447-59

Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2010. Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion. Pain, 151 2, 447-59

Xie, W.; Strong, J. A.; Zhang, J. M. 2009. Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models Neuroscience, 160 4 , 847-857

Xie, W; Strong, J A; Zhang, J-M 2009. Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models. Neuroscience, 160 4, 847-57

Yang, R. H.; Strong, J. A.; Zhang, J. M. 2009. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons Mol Pain, 5 2 , 26

Yang, Rui-Hua; Strong, Judith A; Zhang, Jun-Ming 2009. NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons. Molecular pain, 5 , 26

Wang, J. G.; Strong, J. A.; Xie, W.; Yang, R. H.; Coyle, D. E.; Wick, D. M.; Dorsey, E. D.; Zhang, J. M. 2008. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons Mol Pain, 4 5 , 38

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Yang, Rui-Hua; Coyle, Dennis E; Wick, Dayna M; Dorsey, Ericka D; Zhang, Jun-Ming 2008. The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Molecular pain, 4 , 38

Xie, W.; Strong, J. A.; Zhang, J-M 2008. Sympathetic nerve sprouting is closely related to the pattern of spontaneous activity in axotomized DRG neurons Sheng Li Xue Bao, 759 5 , 2

Zhang, J. M.; Strong, J. A. 2008. Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain Sheng Li Xue Bao, 60 5 , 617-27

Zhang, Jun-Ming; Strong, Judith A 2008. Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain. Sheng li xue bao : [Acta physiologica Sinica], 60 5, 617-27

Li, H.; Xie, W.; Strong, J. A.; Zhang, J.-M. 2007. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain Anesthesiology, 107 3 , 469-77

Li, Huiqing; Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming 2007. Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain. Anesthesiology, 107 3, 469-77

Strong, Judith Ann 2007. Genetics of pain: lessons for future studies. International anesthesiology clinics, 45 2, 13-25

Wang, J. G.; Strong, J. A.; Xie, W.; Zhang, J. -M. 2007. Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons Anesthesiology, 107 2 , 322-32

Wang, Jun-Gang; Strong, Judith A; Xie, Wenrui; Zhang, Jun-Ming 2007. Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons. Anesthesiology, 107 2, 322-32

Xie, W.; Strong, J. A.; Li, H.; Zhang, J. -M. 2007. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block J Neurophysiol, 97 1 , 492-502

Xie, Wenrui; Strong, Judith Ann; Li, Huiqing; Zhang, Jun-Ming 2007. Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block. Journal of neurophysiology, 97 1, 492-502

Strong, Judith A; Dalvi, Arif; Revilla, Fredy J; Sahay, Alok; Samaha, Frederick J; Welge, Jeffrey A; Gong, Jianhua; Gartner, Maureen; Yue, Xia; Yu, Lei 2006. Genotype and smoking history affect risk of levodopa-induced dyskinesias in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 21 5, 654-9

Wang, J.; Strong, J.A.; Zhang, J.-M. 2006. Localized inflammation alters excitability and ion currents in rat sensory neurons J Neurophysiol, 31 1 , 492-502

Xie, W. R.; Deng, H.; Li, H.; Bowen, T. L.; Strong, J. A.; Zhang, J. -M. 2006. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia Neuroscience, 142 3 , 809-822

Xie, W-R; Deng, H; Li, H; Bowen, T L; Strong, J A; Zhang, J-M 2006. Robust increase of cutaneous sensitivity, cytokine production and sympathetic sprouting in rats with localized inflammatory irritation of the spinal ganglia. Neuroscience, 142 3, 809-22

Wang, X.; Zhang, Y.; Kong, L.; Xie, Z.; Lin, Z.; Guo, N.; Strong, J. A.; Meij, J. T.; Zhao, Z.; Jing, N.; Yu, L. 2005. RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour Neuroscience, 22 5 , 1090-6

Xie, W.; Strong, J. A.; Meij, J. T.; Zhang, J. -M.; Yu, L. 2005. Neuropathic pain: Early spontaneous afferent activity is the trigger Pain, 116 3 , 243-56

Xie, Wenrui; Strong, Judith A; Meij, Johanna T A; Zhang, Jun-Ming; Yu, Lei 2005. Neuropathic pain: early spontaneous afferent activity is the trigger. Pain, 116 3, 243-56

Zheng, W.; Xie, W.; Zhang, J.; Strong, J. A.; Wang, L.; Yu, L.; Xu, M.; Lu, L. 2003. Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord J Biol Chem, 278 48 , 48321-9

Bond, C.; LaForge, K. S.; Tian, M.; Melia, D.; Zhang, S.; Borg, L.; Gong, J.; Schluger, J.; Strong, J. A.; Leal, S. M.; Tischfield, J. A.; Kreek, M. J.; Yu, L. 1998. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction Proc Natl Acad Sci U S A, 95 16 , 9608-13

Gong, J; Strong, J A; Zhang, S; Yue, X; DeHaven, R N; Daubert, J D; Cassel, J A; Yu, G; Mansson, E; Yu, L 1998. Endomorphins fully activate a cloned human mu opioid receptor. FEBS letters, 439 1-2, 152-6

Xie, Wenrui; Strong, Judith A; Zhang, Jun-Ming . Active Nerve Regeneration with Failed Target Reinnervation Drives Persistent Neuropathic Pain. eNeuro, 4 1,