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Department of Internal Medicine

Infectious Diseases

Photo of  Michael Linke, PhD

Michael Linke, PhD

Volunteer Associate Professor of Medicine

Education/Credentials
  • Bachelor's Degree: St. Joseph's College
  • Master's Degree: St. Thomas Institute
  • Doctoral Degree: University of Cincinnati
  • Fellowship: Children's Hospital Research Foundation

Contact Information
  • Cincinnati Department of Veteran Affairs Medical Center
  • 3200 Vine Street
  • Cincinnati, Ohio 45220
  • Office 513-861-3100
  • Fax 513-475-6415
  • Email Michael.Linke@va.gov

Peer Reviewed Publications

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Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T 2013. Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infection and immunity, 81 3, 984-95

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D 2010. Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PloS one, 5 1, e8524

Cushion, Melanie T; Collins, Margaret S; Linke, Michael J 2009. Biofilm formation by Pneumocystis spp. Eukaryotic cell, 8 2, 197-206

Linke, Michael J; Ashbaugh, Alan D; Demland, Jeffery A; Walzer, Peter D 2009. Pneumocystis murina colonization in immunocompetent surfactant protein A deficient mice following environmental exposure. Respiratory research, 10 , 10

Koneti, Adi; Linke, Michael J; Brummer, Elmer; Stevens, David A 2008. Evasion of innate immune responses: evidence for mannose binding lectin inhibition of tumor necrosis factor alpha production by macrophages in response to Blastomyces dermatitidis. Infection and immunity, 76 3, 994-1002

Motz, Gregory T; Eppert, Bryan L; Sun, Guangyun; Wesselkamper, Scott C; Linke, Michael J; Deka, Ranjan; Borchers, Michael T 2008. Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema. Journal of immunology (Baltimore, Md. : 1950), 181 11, 8036-43

Keely, Scott P; Linke, Michael J; Cushion, Melanie T; Stringer, James R 2007. Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription. Fungal genetics and biology : FG & B, 44 9, 905-19

Lekkala, Madhavi; LeVine, Ann Marie; Linke, Michael J; Crouch, Erika C; Linders, Bruce; Brummer, Elmer; Stevens, David A 2006. Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by surfactant protein D. Infection and immunity, 74 8, 4549-56

Linke, Michael; Ashbaugh, Alan; Demland, Jeffery; Koch, Judith; Tanaka, Reiko; Walzer, Peter 2006. Resolution of Pneumocystis murina infection following withdrawal of corticosteroid induced immunosuppression. Microbial pathogenesis, 40 1, 15-22

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter 2006. Efficient resolution of Pneumocystis murina infection in surfactant protein A-deficient mice following withdrawal of corticosteroid-induced immunosuppression. Journal of medical microbiology, 55 Pt 2, 143-7

Linke, Michael; Ashbaugh, Alan; Koch, Judith; Tanaka, Reiko; Walzer, Peter 2005. Surfactant protein A limits Pneumocystis murina infection in immunosuppressed C3H/HeN mice and modulates host response during infection. Microbes and infection / Institut Pasteur, 7 4, 748-59

Wagner, Kenneth R; Dean, Christopher; Beiler, Shauna; Bryan, David W; Packard, Benjamin A; Smulian, A George; Linke, Michael J; de Courten-Myers, Gabrielle M 2005. Plasma infusions into porcine cerebral white matter induce early edema, oxidative stress, pro-inflammatory cytokine gene expression and DNA fragmentation: implications for white matter injury with increased blood-brain-barrier permeability. Current neurovascular research, 2 2, 149-55

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D 2004. Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids. Infection and immunity, 72 2, 757-65

Linke, Michael J; Rebholz, Sandy; Collins, Margaret; Tanaka, Reiko; Cushion, Melanie T 2003. Noninvasive method for monitoring Pneumocystis carinii pneumonia. Emerging infectious diseases, 9 12, 1613-6

Thullen, Timothy D; Ashbaugh, Alan D; Daly, Kieran R; Linke, Michael J; Steele, Paul E; Walzer, Peter D 2003. New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies. Infection and immunity, 71 11, 6292-7

Daly, Kieran R; Fichtenbaum, Carl J; Tanaka, Reiko; Linke, Michael J; O'Bert, Robert; Thullen, Timothy D; Hui, Michele S; Smulian, Alan G; Walzer, Peter D 2002. Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons. The Journal of infectious diseases, 186 5, 644-51

Wagner, Kenneth R; Packard, Benjamin A; Hall, Cathy L; Smulian, A George; Linke, Michael J; De Courten-Myers, Gabrielle M; Packard, Lori M; Hall, Nathan C 2002. Protein oxidation and heme oxygenase-1 induction in porcine white matter following intracerebral infusions of whole blood or plasma. Developmental neuroscience, 24 2-3, 154-60

Linke, Michael J; Ashbaugh, Alan A; Koch, Judith V; Levin, Linda; Tanaka, Reiko; Walzer, Peter D . Effects of surfactant protein-A on the interaction of Pneumocystis murina with its host at different stages of the infection in mice. The Journal of eukaryotic microbiology, 56 1, 58-65