Kristin Hudock, MD, MSTR Laboratory
We seek to understand how an individual’s innate immune response contributes to the pathogenesis of cystic fibrosis (CF), acute respiratory distress syndrome (ARDS) and pneumonia. To accomplish this goal, we combine basic and translational approaches to discover what regulates the balance between host defense and tissue injury in human lung and inflammatory diseases.
We utilize primary human cells, murine models and patient samples to generate new knowledge regarding disease mechanisms with the goal of uncovering unique therapeutic targets. We use our expertise in human induced pluripotent stem cells (iPSCs) to define crucial genes-to-function relationships that modify neutrophil behaviors. Our lab has specific interests in cytokine networks, neutrophil extracellular traps (NETs) and NETosis.
We also employ the aforementioned strategies to elucidate novel mechanisms in human disorders causing neutropenia, including poikiloderma with neutropenia (PN).
Dr. Hudock has joint appointments in the University of Cincinnati (UC) Division of Pulmonary, Critical Care and Sleep Medicine as well as the Cincinnati Children's Hospital Medical Center (CCHMC) Division of Pulmonary Biology. She recently moved here from Philadelphia and enjoys hiking in the area’s many parks with her husband and dogs.
Collaborations: Our work is enriched by collaborations with, and mentorship from, investigators in various disciplines including Dr. Bruce Trapnell, Dr. JP Clancy, Dr. Frank McCormack, Dr. Jeffrey Whitsett and Dr. Scott Worthen. Please contact Dr. Hudock if you would like to collaborate with our lab.
Graduate Students/ Residents/ Fellows: We welcome applications to do rotations in our lab. Highly motivated individuals enrolled in, or who have recently completed, MD or PhD programs please contact Dr. Hudock directly.
Funding: Our work is funded by the NIH, UC CCTST CT2 Scholar program, Parker B. Francis Foundation, Cystic Fibrosis Foundation, UC College of Medicine and Cincinnati Children’s.