Departments / Environmental & Public Health Sciences / Research / Research Projects / Fernald Community Cohort / Publications

Publications Emerging from the FCC Data and Biospecimens

  1. Copeland BE, Pesce AJ. The Medical Heritage Concept: A Model for Assuring Comparable Laboratory Results in Long-Term Longitudinal Studies. Ann Clin Lab Sci 1992; 22(2):110-124. PMID: 1562165
    https://www.ncbi.nlm.nih.gov/pubmed/1562165
  2. Wones R, Radack K, Martin V, Mandell K, Pinney S, Buncher R.  Do persons living near a uranium processing site have cytogenetic damage?  Mutation Research 1995; 335:171-184. PMID: 7477048.
    http://www.sciencedirect.com/science/article/pii/0165116195900535
  3. Radack KL, Pinney SM, Livingston GK.  Sources of variability in the human lymphocyte micronucleus assay: A population-based study, Environmental and Molecular Mutagenesis 1995; 26:26-36. PMID: 7641705
    https://www.ncbi.nlm.nih.gov/pubmed/7641705
  4. Radack K, Martin V, Wones R, Buncher R, Pinney S, Mandell K. Intercorrelations and sources of variability in three mutagenicity assays of somatic mutations: A population-based study. Mutation Research 1996; 350:295-306. PMID: 8600359
    http://www.sciencedirect.com/science/article/pii/002751079500162X
  5. De BK, Karr BA, Ghosn S, Copeland BE. Problems and Practical Considerations in Assessing Accuracy with NIST SRM 909a; Report of Defective Vials. Clinical Chemistry 1996; 42(11):1832-1837. PMID:8906084
    http://clinchem.aaccjnls.org/content/42/11/1832.long
  6. Woo JG, Pinney SM. Retrospective Smoking History Data Collection for Deceased Workers: Completeness and Accuracy of Surrogate Reports. JOEM 2002; 44(10):915-923. PMID: 12921382
    http://journals.lww.com/joem/pages/articleviewer.aspx?year=2002&issue=10000&article=00010&type=abstract
  7. Pinney SM, Freyberg RW, Levine GH, Brannen DE, Mark LS, Nasuta JM, Tebbe CD, Buckholz JM, Wones R.  Health Effects in Community Residents Near a Uranium Plant at Fernald, Ohio, USA.  International Journal of Occupational Medicine and Environmental Health 2003; 16(2):139-153. PMID: 12921382
    https://www.ncbi.nlm.nih.gov/pubmed/?term=Health+Effects+in+Community+Residents+Near+a+Uranium+Plant+at+Fernald%2C+Ohio%2C+USA
  8. Bailey-Wilson JE*, Amos CI, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain P, Schwartz AG, You M, Franklin W, Klein C, Gazdar A, Rothschild H, Mandal D, Coons T, Slusser J, Lee J, Gaba C, Kupert E, Perez A, Zhou X, Zeng D, Liu Q, Zhang Q, Seminara D, Minna J, Anderson M.  A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics 2004; 75:460-474. Epub 2004 Jul 21.PMID: 15272417 http://www.sciencedirect.com/science/article/pii/S0002929707633175
  9. Gerhardstein BG, Brown P. The Benefits of Community Medical Monitoring at Nuclear Weapons Production Sites: Lessons From Fernald. Environmental Law Review News & Analysis 2005; 35:10531-10538. No PMID
    http://eh.uc.edu/assets/uploads/2015/02/35.10530.pdf
  10. Brown MK, Verkamp S, Yocum E, Schrorr C. Fernald Area Cisterns and Wells: What is Known and What Do We Need To Know? The findings of the MTA project are provided in their entirety on CD (publication 2006), in bound Manual (publication 2008) and at the following websites: www.fernalkdfchec.com, www.mtafund.org.
    http://fernaldfchec.com/Project.html
  11. Wang M, Vikis HG, Wang Y, Jia D, Wang D, Bierut LJ, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Jinna J, Gaba C, Rothchild H, Mandal D, Kupert E, Seminara D, Liu Y, Viswanathan A, Govindan R, Anderson W, You M.  Identification of a Novel Tumor Suppressor Gene p34 on Human Chromosome 6q25.1.  Cancer Research  2007; 67(1): 93-99. PMID: 17210687
    http://cancerres.aacrjournals.org/content/67/1/93.long
  12. Vikis H, Sato M, James M, Wang D,  Wang Y, Wang M, Jia D, Liu Y, Bailey-Wilson JE, Amos CI, Pinney SM, Petersen GM, de Andrade M, Yang P, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Kupert E, Seminara D,  Viswanathan A, Govindan R, Minna J, Anderson MW, You M.  EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.  Cancer Research 2007; 67(10): 4665-70. PMID: 17510392
    http://cancerres.aacrjournals.org/content/67/10/4665.long
  13. Hornung RW, Pinney SM, Lodwick J, Killough G, Brewer DE, Nasuta J. Estimation of Radon Exposures to Workers at the Fernald Feed Materials Production Center, 1952-1988. Journal of Exposure Science and Environmental Epidemiology 2008; 18(5):512-523. Epub 2008 Jan 9. PMID: 18183043
    http://www.nature.com/jes/journal/v18/n5/full/7500645a.html
  14. Liu P, Vikis HG Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Peterson GM, Weist JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee, J, Kupert E, Seminara D, Minna J, Bailey- Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M. Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer. Journal of the National Cancer Institute 2008; 100(18):1326-1330. PMID: 18780872
    http://jnci.oxfordjournals.org/content/100/18/1326.long
  15. You M*, Wang D*, Liu P*, Vikis H*, James M*, Lu Y, Wang Y, Wang M, Jia D, Liu Y, Yang P, Zheng W, Shu XO, Long J, Gao YT, Xiang YB, Chow WH, Pinney SM, Petersen GM, de Andrade M, Wiest JS, Fain PR, Schwartz AG, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Amos CI, Anderson MW . Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.  Clinical Cancer Research 2009; 15(8); 2666-73. Epub 2009 Apr 7. PMID: 19351763
    http://clincancerres.aacrjournals.org/content/15/8/2666.long
  16. Christiani DC. Lung Cancer Genetics: A Family Affair. Clin Cancer Res 2009; 15(8):2581-2582. PMID: 19351746
    http://clincancerres.aacrjournals.org/content/15/8/2581.long
  17. Wones R, Pinney SM, Buckholz JM, Deck-Tebbe C, Freyberg R, Pesce A. Medical Monitoring: A Beneficial Remedy for Residents Living Near an Environmental Hazard Site.  J Occup Environ Med. 2009; 51:1374–1383. PMID: 19952785  doi: 10.1097/JOM.0b013e3181c558f1http://journals.lww.com/joem/pages/articleviewer.aspx?year=2009&issue=12000&article=00007&type=abstract
  18. Liu Y, Liu P, Wen W, James MA, Wnag Y, Bailey-Wilson JE, Amos CI, PInney SM, Yang P, de Andrade M, Peterson GM, Wiest JS, Pain PR, Schwartz AG, Gazdar A, Gaba C, Pothschild H, Mandal D, Kupert E, Lee J, Seminara D, Minna J, Anderson MW, You M. Haplotype cell proliferation analyses of candidate lung cancer susceptibility genes on chromosomes 15q24-25.1. Cancer Research 2009; 69(19): 7844-7850. PMID: 1978933
    http://cancerres.aacrjournals.org/content/69/19/7844.long
  19. Amos CI, Pinney SM, Li Y, Kupert E, Lee J, de Andrade MA, Yang P, Schwartz AG, Fain PR, Gazdar A, Minna J, Wiest J, Zeng D, Rothschild H, Mandal D, You M, Coons T, Gaba C, Bailey-Wilson JE, Anderson MW.  A susceptibility locus on chromosome 6q greatly increases risk lung cancer risk among light and never smokers. Cancer Research 2010; 70(6):2359-2367. Epub 2010 Mar 9. PMID: 20215501
    http://cancerres.aacrjournals.org/content/70/6/2359.long
  20. Liu P, Yang P, Wu X, Vikis HG, Lu Y, Wang Y, Schwartz AG, Pinney SM, de Andrade M, Gazdar A, Gaba C, Mandal D, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Spitz M, Amos CI, Anderson MW, You M. A Second Genetic Variant on Chromosome 15q24-25.1 Associates with Lung Cancer. Cancer Research 2010; 70(8): 3128-35. PMID: 20395203
    http://cancerres.aacrjournals.org/content/70/8/3128.long
  21. Fang S, Pinney SM, Bailey-Wilson J, de Andrade M, Li Yafang, Kupert E, You M, Schwartz A, Yang P, Anderson M, Amos CI.  Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q. Cancer Epidemiol Biomarkers Prev 2010; 19(12):3157-66. Epub 2010 Oct 28. PMID: 21030603 http://cebp.aacrjournals.org/content/19/12/3157.long
  22. Wagner SE, Burch JB, Bottai M, Puett R, Porter D, Pinney SM, Vena JE, J.R. Hypertension and hematologic parameters in a community near a uranium processing facility. Environmental Research 2010; 110(8):786-797. PMID: 20889151
    http://www.sciencedirect.com/science/article/pii/S0013935110001465
  23. Yaghjyan L, Pinney SM, Mahoney MC, Morton AR, Buckholz J, Samaratunga R. Mammographic Breast Density Assessment: A Methods Study. Atlas Journal of Medical & Biological Sciences 2011; 1(1): 8-14. No PMID
    http://www.atlas-publishing.org/wp-content/uploads/2013/07/2-AJMBS-Yaghiyan_et_al_2011.pdf
  24. Kupert E, Anderson M, Liu Y, Succop P, Levin L, Wang J, Wikenheiser-brokamp K, Chen P, Pinney SM, Macdonald T,  Dong Z, Starnes S, Lu S.  Plasma secretory phospholipase A2-lll as a potential biomarker for lung cancer in patients with solitary pulmonary nodules.  BCM Cancer 2011; 11:513. PMID: 22151235
    https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-513
  25. Yaghjyan L, Mahoney MC, Succop P, Wones R, Buckholz J, Pinney SM. Relationship between breast cancer risk factors and mammographic breast density in Fernald Community Cohort. British Journal of Cancer 2012; 106(5): 996-1003. Epub 2012 Jan 26. PMID: 22281662
    http://www.nature.com/bjc/journal/v106/n5/full/bjc20121a.html
  26. Blomkalns AL, Gavrila D, Thomas M, Nelter BS, Blanco VM, Benjamin SB, McCormick ML, Stoll LL, Denning GM, Collins SP, Qin Z, Daugherty A, Cassis LA, Thompson RW, Weiss RM, Linkower PD, Pinney SM, Chatterjee T, Weintraub NL. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation.  J Am Heart Assoc 2013; 8(2):2. PMID: 23537804
    http://jaha.ahajournals.org/content/2/2/e000065.long
  27. Lu PY, Kottyan LC, James JA, Xie C, Buckholz JM, Pinney SM, Harley JB. Systemic Lupus Erythematosus is Associated with Uranium Exposure in a Community Living Near a Uranium Processing Plant: A Nested Case-Control Study.  Arthritis and Rheumatology 2014; 66(11):3105-3112. PMID: 25103365 http://onlinelibrary.wiley.com/doi/10.1002/art.38786/abstract;jsessionid=ADA04BD338DC7990D56CBD8DB52A513C.f04t04
  28. Xiong D, Wang Y, Kupert E, Simpson C, Pinney SM, Gaba CR, Mandal D, Schwartz AG, Yang P, de Andrade M, Pikielny C, Byun J, Li Y, Stambolian D, Spitz MR, Amos CI, Bailey-Wilson JE, Anderson MW, You M.  A recurrent mutation in PARK2 in familial lung cancer.  Am J Hum Genet 2015; 96(2):301-308. Epub 2015 Jan 29. PMID:25640678 http://www.sciencedirect.com/science/article/pii/S0002929714005229
  29. Yang S, Pinney SM, Mallick P, Ho SM, Bracken B, Wu T. Impact of Oxidative Stress Biomarkers and Carboxymethyllysine (an Advanced Glycation End Product) on Prostate Cancer: A Prospective Study. Clin Genitourin Cancer. 2015 Apr 18. pii: S1558-7673(15)00076-2. doi: 10.1016/j.clgc.2015.04.004. [Epub ahead of print]. PMID:25972296.
    http://www.sciencedirect.com/science/article/pii/S1558767315000762
  30. Xie, C., Ghulam, E., Chen, A., Wang, K., Pinney, S., & Lindsell, C. (2015). Weighted Multiple Testing Correction for Correlated Endpoints in Survival Data. In D. Chen, J. Wilson (Eds), Innovative Statistical Methods for Public Health Data (pp315-323) Switzerland: Springer International Publishing.
    http://link.springer.com/chapter/10.1007/978-3-319-18536-1_14/fulltext.html
  31. Pinney SM, Biro FM.  Letter to the editor re Morollo-Frosh “Communicating Results in Post-Belmont Era Biomonitoring Studies”.  Environ Res. 2015; June 12. [Epub ahead of print].  26076818.
    http://www.sciencedirect.com/science/article/pii/S001393511500170X
  32. Liu Y, Kheradmand F, Davi CF1, Scheurer ME, Wheeler D, Tsavachidis S, Armstrong G, Simpson C, Mandal D, Kupert E, Anderson M, You M, Xiong D, Pikielny C, Schwartz AG, Bailey-Wilson JE, Gaba C, De Andrade M, Yang P, Pinney SM, The Genetic Epidemiology of Lung Cancer Consortium, Amos CI, Spitz MR.  Focused Analysis of Exome Sequencing Data for Rare Mutations in Familial and Sporadic Lung Cancer.  In press, Journal of Thoracic Oncology. 2016 Jan;11(1):52-61. doi: 10.1016/j.jtho.2015.09.015.
    http://www.sciencedirect.com/science/article/pii/S1556086415000246
  33. Jorge-Nebert LF, Zhang G, Wilson KM, Jiang Z, Butler R, Gluckman JL, Pinney SM, Nebert DW. Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.  Hum Genomics 2016; 10(1): 39.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127090/
  34. Martin AT, Pinney SM, Xie C, Herrick RL, Bai Y, Buckholz J, Martin VT.  Headache Disorders are a Risk Factor for the Development of New Onset Hypothyroidism.  Headache 2017; 57:21-30. doi: 10.1111/head.12943. Epub 2016 Sep 27. PMID: 27676320.
    http://onlinelibrary.wiley.com/doi/10.1111/head.12943/abstract
  35. Li D, Mai V, Gerke T, Pinney SM, Yaghjyan L.  Interactions of Family History of Breast Cancer with Radiotherapy in Relation to Risk of Breast Cancer Recurrence.  J Breast Cancer 2017; 20(4):333-339.  doi: 10.4048/jbc.2017.20.4.333. Epub 2017 Dec 19. PMID: 29285037 PMCID:PMC5743992
    https://pubmed.ncbi.nlm.nih.gov/29285037
  36. Herrick RL, Buckholz JM, Biro FM, Calafat AM, Ye X, Xie C, Pinney SM. Polyfluoroalkyl substance exposure in the Mid-Ohio River Valley, 1991-2012. Environmental Pollution 2017; 228: 50-60.
    http://www.sciencedirect.com/science/article/pii/S0269749117301264
  37. Musolf AM, Simpson CL, de Andrade M, Mandal D, Gaba C, Yang P, Li Y, You M, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE. Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer. Hum Hered. 2016;82(1-2):64-74. doi: 10.1159/000479028. Epub 2017 Aug 18  PMID:28817824
    https://pubmed.ncbi.nlm.nih.gov/28817824
  38. Byun J, Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M, Kupert EY, Anderson MW, Han Y, Byun J, Li Y, Qian D, Stilp A, Laurie C, Nelson S, Zheng W, Hung RJ, Gaborieau V, McKay J, Brennan P, Caporaso NE, Landi MT, Wu X, McLaughlin JR, Brhane Y, Bosse Y, Pinney SM, Bailey-Wilson JE, Amos CI. Genome-wide association study of familial lung cancer.  Carcinogenesis 2018; 39(9):1135-1140.
    https://www.ncbi.nlm.nih.gov/pubmed/29924316
  39. Giannini CM, Herrick RL, Buckholz JM, Daniels AR, Biro FM, Pinney SM . Comprehension and Perceptions of Study Participants Upon Receiving Perfluoroalkyl Substance Exposure Biomarker Results.  Journal of Industrial Hygiene and Public Health 2018; 221(7):1040-1046.  DOI: 10.1016/j.ijheh.2018.07.005.  PMID: 30025914
    https://www.ncbi.nlm.nih.gov/pubmed/30025914
  40. Blake BE, Pinney SM, Hines EP, Fenton SE, Ferguson KK. Associations between serum perfluoroalkyl substance (PFAS) levels and measures of thyroid hormone, kidney function, and body mass index in the Fernald Community Cohort.  Environmental Pollution 2018; 242(A):894-904.  doi.org/10.1016/j.envpol.2018.07.042
    https://www.ncbi.nlm.nih.gov/pubmed/30373035
  41. Liu Y, Lusk C, Cho M, Ahang R, Scheurer M, Kheradmand F, Qiao D, Wheeler D, Tsavachidis S, Armstrong G, Chow C-W, Behrens C, Pikielny C, Neslund-Dudas C, Pinney SM, Bailey-Wilson J, Gaba C, Mandal D, Wistuba I, Amos C, Silverman E, Schwartz AG, Spitz M. Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer.  Journal of Thoracic Oncology 2018; 13(10):1483-1495. doi: 10.1016/j.jtho.2018.06.016 PMID: 29981437 PMCID: PMC6366341
    https://pubmed.ncbi.nlm.nih.gov/29981437
  42. Greene AD, Kendziorski JA, Buckholz JM, Niu L, Xie C, Pinney SM, Burns KA . Elevated serum chemokines are independently associated with both endometriosis and uranium exposure. Reproductive Toxicology 2018; 84: 26-31. doi.org/10.1016/j.reprotox.2018.12.006
    https://www.ncbi.nlm.nih.gov/pubmed/30373035
  43. Salerno J, Peters E, Pinney SM, Morain S, Hlaing WWM, Goodman KW.  Untangling the Ethical Intersection of Epidemiology, Human Subjects Research and Public Health. In press, Annals of Epidemiology, 2019. Jun;34:1-5. doi: 10.1016/j.annepidem.2019.03.009. Epub 2019 Mar 27  https://www.sciencedirect.com/science/article/pii/S1047279718309542?via%3Dihub
  44. Musolf AM, Simpson CJ, Moiz BA, Pikielny CW, Middlebrooks CD, Mandal D, de Andrade M, Cole MD, Gaba C, Ping Yang P, You M, Li Y, Kupert EY, Anderson MW, Schwartz AG, Pinney SM, Amos CI and Bailey-Wilson JE. Genetic variation and recurrent haplotypes on chromosome 6q23-25 risk locus in familial lung cancer.  Cancer Research 2021 online first April 14.  doi: 10.1158/0008-5472.CAN-20-3196
    https://pubmed.ncbi.nlm.nih.gov/33853833
  45. Liu Y, Xia J, McKay J, Tsavachidis S, Xiao X, Spitz MR, Cheng C, Byun J, Hong W, Li Y, Zhu D, Song Z, Rosenberg SM, Scheurer ME, Kheradmand F, Pikielny CW, Lusk CM, Schwartz AG, Wistuba II, Cho MH, Silverman EK, Bailey-Wilson J, Pinney SM, Anderson M, Kupert E, Gaba C, Mandal D, You M, de Andrade M, Yang P, Liloglou T, Davies MPA, Lissowska J, Swiatkowska B, Zaridze D, Mukeria A, Janout V, Holcatova I, Mates D, Stojsic J, Scelo G, Brennan P, Liu G, Field JK, Hung RJ, Christiani DC, Amos CI. Rare deleterious germline variants and risk of lung cancer. NPJ Precis Oncol. 2021 Feb 16;5(1):12. doi: 10.1038/s41698-021-00146-7. PMID: 33594163
    https://pubmed.ncbi.nlm.nih.gov/33594163
  46. Musolf AM, Moiz BA, Sun H, Pikielny CW, Bossé Y, Mandal DM, de Andrade M, Gaba C, Yang P, Li Y, You M, Govindan R, Wilson RK, Kupert EY, Anderson M, Schwartz AG, Pinney SM, Amos CI, Bailey-Wilson JE. Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p and 4q.  Cancer Epidemiology, Biomarkers and Prevention, 2020. Feb;29(2):434-442. doi: 10.1158/1055-9965.EPI-19-0887. Epub 2019
    Dec 11. PMID:31826912 PMCID: PMC7007362
    https://pubmed.ncbi.nlm.nih.gov/31826912

 

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