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Goal

To describe transport of steroid hormones in the circulation and the involvement of the liver, kidneys and peripheral tissues in metabolism and excretion of steroid hormones.

-What are the principal metabolites of steroid hormones?
-What are the principal conjugates of steroid horomones?
-What are the routes of excretion of steroid hormones?
-What is the half-life of each of the major steroid hormones in the ciruculation?
-How does a steroid hormone circulate after being synthesized in ovarian cells?
-How does a steroid hormone circulate after being ingested?

 

After the steroid is synthesized it will move through the circulation to the heart. Then it will move through the body acting in target tissues such as the uterus. Other important tissues that steroid hormones move through are the liver and the kidneys. The steroids will then return to the heart and continue circulating through the bloodstream.

When steroid hormones circulate through the liver they are deactivated and no longer effect the body. As hormones move to the kidneys through the circulation they will eventually be excreted into the urine. After being ingested all steroids move from the gut directly to liver via the inter circulation, the liver then inactivates the steroid hormones.