Pharmacology & Systems Physiology Graduate Programs
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Pharmacology PhD Program
Pharmacology: Dissertation Research
Dissertation Research
Learn More About Pharmacology: Dissertation ResearchCareers & Alumni in Pharmacology
PhD graduates pursue diverse career paths. Where are they now?
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Physiology: Dissertation Research
Careers & Alumni in Physiology
PhD graduates pursue diverse career paths. Where are they now? Click below to learn more
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Research Opportunities
Student Highlights
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Faculty Research
Guochang Fan, PhD |
Regulatory roles of microRNAs and exosome signaling pathway in sepsis-, diabetes- and infarction-induced heart failure; 2) protective roles of stem cell-derived exosomes in cardiovascular disease; and 3) the influence of microRNAs on bone marrow-derived mesenchymal stem cell behavior |
James Herman, PhD |
1) limbic system regulation of the stress response and, consequently, on the generation of stress-related disorders, ranging from major depressive illness to essential hypertension to neurodegeneration and aging, and |
Andy Norman, PhD |
Development of quantitative pharmacological models of addictive behavior. These models can then be used to predict the clinical efficacy of potential medications for the treatment of cocaine and other addictions. Dr. Norman leads a multidisciplinary team that is developing human anti-cocaine monoclonal antibodies suitable for use as therapeutic agents for the prevention of relapse in cocaine addicts. |
Hong-Sheng Wang, PhD |
We are interested in the impact of environmental pollutants on the heart and circulatory system. We use a combination of pharmacology, toxicology, cardiac physiology and electrophysiology techniques to address how environmental chemicals may contribute to abnormal heart function, arrhythmias, and excessive blood coagulation. We are also interested in cardiac ion channels and how they contribute to heart physiology and diseases. |
Tongli Zhang, PhD |
In my research, I combine biological intuition with mathematical modeling to make clear the seemingly confusing networks. My biological intuition is on cell cycle, apoptosis, p53 pathway and NF-κB pathway. My modeling expertise is on positive feedbacks, negative feedbacks, switches, and oscillations. |
Zalfa Abdel-Malek, PhD |
Regulation of human pigmentation, photobiology and photocarcinogenesis, genetic susceptibility to melanoma; role of melanocortins and the melanocortin 1 receptor |
Hassane Amlal, PhD |
Regulation of acid-base transporters, glutamine metabolism, and inorganic phosphate in health and disease |
Mark Baccei, PhD |
Characterization of the short- and long-term consequences of tissue injury during early life for the function of developing synaptic networks in the superficial dorsal horn of the spinal cord |
George Deepe, MD |
Cellular immunology of fungal infections; characterization of the protective T-cell epitopes of H. capsulatum antigens and analysis of the functional activity of antigen-reactive T-cells |
Senad Divanovic, PhD |
Our research program focuses on the role of immune response in inflammation and metabolism. Our expertise in pathways that regulate innate immunity — developed through the pursuit of studies ranging from reductive analysis of TLR ligand signaling to the role of IL-17 axis in experimental models of obesity and infection — have spearheaded the projects aimed at defining the role of the immune mediators in the development and progression of obesity, obesity-associated sequelae and infection / inflammation driven preterm birth. |
David Hui, PhD |
Lipid Metabolism, Atherosclerosis, Diabetes, Obesity, Vascular Biology |
Jeffrey Molkentin, PhD |
Molecular biology of heart and skeletal muscle disease |
Laura Ramsey, PhD |
The Ramsey lab is interested in all aspects of pharmacogenetics, from basic research to implementation in patient care. Pharmacogenetics refers to the effect of a person’s genetic code on his/her response to a medication. Research has been done in this field for decades, but only recently has pharmacogenetic information been incorporated into clinical care. There are now guidelines for dosing of more than 30 drugs based on genetic information, provided by the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC). Many of the genes involved in response to medication alter the pharmacokinetics of the drug (the speed at which it’s absorbed, distributed, metabolized or eliminated). |
Jack Rubinstein, MD |
Advanced Echocardiographic Imaging, Myocardial Energy Utilization |
Sakthivel Sadayappan, PhD, MBA |
The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. The sarcomere is the functional unit of striated muscle to generate contractility. |
Michael Tranter, PhD |
The long-term goals of my research are to increase our understanding of the molecular mechanisms of cardiovascular disease. Within this realm, the ongoing work in the laboratory is broadly centered around post-transcriptional gene regulation in the setting of (1) pathological left ventricular hypertrophy and fibrosis, and (2) the mechanisms of cardioprotection against ischemia/reperfusion injury. |
Patrick Tso, PhD |
One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine. The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology. |
Jun-Ming Zhang, MD |
Physiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain. Specifically, we are interested in whether extended nerve block provides additional benefit for patients with traumatic injury in lowing the risk of chronic pain; and how to improve efficacy of epidural steroids for managing low back pain. |

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