Education/CredentialsMBA: University of Cincinnati (Project Administration and Marketing )PhD: Madurai Kamaraj University (Molecular Aspects of Cardiac Hypertrophy) Contact Information Cardiovascular Rsrch Cntr 3923 Office 513-558-7498 Email sadayasl@ucmail.uc.edu Research InterestsThe long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. Peer Reviewed Publications Becker, Richard C; Owens, A Phillip; Sadayappan, Sakthivel 2020. Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy. Journal of thrombosis and thrombolysis, 49 2, 177-183Becker, Richard C; Sadayappan, Sakthivel 2020. Designing Human In Vitro Models for Drug Development. Journal of the American College of Cardiology, 75 6, 587-589Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J 2020. Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation. JACC. Basic to translational science, 5 2, 109-122Vagnozzi, Ronald J; Maillet, Marjorie; Sargent, Michelle A; Khalil, Hadi; Johansen, Anne Katrine Z; Schwanekamp, Jennifer A; York, Allen J; Huang, Vincent; Nahrendorf, Matthias; Sadayappan, Sakthivel; Molkentin, Jeffery D 2020. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature, 577 7790, 405-409Alam, Perwez; Haile, Bereket; Arif, Mohammed; Pandey, Raghav; Rokvic, Miso; Nieman, Michelle; Maliken, Bryan D; Paul, Arghya; Wang, Yi-Gang; Sadayappan, Sakthivel; Ahmed, Rafeeq P H; Kanisicak, Onur 2019. Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction. Journal of the American Heart Association, 8 15, e012089Arif, Mohammed; Sadayappan, Sakthivel; Becker, Richard C; Martin, Lisa J; Urbina, Elaine M 2019. Epigenetic modification: a regulatory mechanism in essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 42 8, 1099-1113Barefield, David Y; McNamara, James W; Lynch, Thomas L; Kuster, Diederik W D; Govindan, Suresh; Haar, Lauren; Wang, Yang; Taylor, Erik N; Lorenz, John N; Nieman, Michelle L; Zhu, Guangshuo; Luther, Pradeep K; Varró, Andras; Dobrev, Dobromir; Ai, Xun; Janssen, Paul M L; Kass, David A; Jones, Walter Keith; Gilbert, Richard J; Sadayappan, Sakthivel 2019. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. Journal of molecular and cellular cardiology, 129 , 236-246Becker, Richard C; Cotarlan, Vlad; Sadayappan, Sakthi 2019. The rapid proliferation of solicited content online journals: a quest to disseminate knowledge? Journal of thrombosis and thrombolysis, 47 3, 337-344Boyer, Justin G; Prasad, Vikram; Song, Taejeong; Lee, Donghoon; Fu, Xing; Grimes, Kelly M; Sargent, Michelle A; Sadayappan, Sakthivel; Molkentin, Jeffery D 2019. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight, 5 , Goh, Qingnian; Song, Taejeong; Petrany, Michael J; Cramer, Alyssa Aw; Sun, Chengyi; Sadayappan, Sakthivel; Lee, Se-Jin; Millay, Douglas P 2019. Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle. eLife, 8 , Ikeda, Shohei; Mizushima, Wataru; Sciarretta, Sebastiano; Abdellatif, Maha; Zhai, Peiyong; Mukai, Risa; Fefelova, Nadezhda; Oka, Shin-Ichi; Nakamura, Michinari; Del Re, Dominic P; Farrance, Iain; Park, Ji Yeon; Tian, Bin; Xie, Lai-Hua; Kumar, Mohit; Hsu, Chiao-Po; Sadayappan, Sakthivel; Shimokawa, Hiroaki; Lim, Dae-Sik; Sadoshima, Junichi 2019. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circulation research, 124 2, 292-305Kuster, Diederik W D; Lynch, Thomas L; Barefield, David Y; Sivaguru, Mayandi; Kuffel, Gina; Zilliox, Michael J; Lee, Kyoung Hwan; Craig, Roger; Namakkal-Soorappan, Rajasekaran; Sadayappan, Sakthivel 2019. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovascular research, 115 14, 1986-1997Li, Amy; Nelson, Shane R; Rahmanseresht, Sheema; Braet, Filip; Cornachione, Anabelle S; Previs, Samantha Beck; O'Leary, Thomas S; McNamara, James W; Rassier, Dilson E; Sadayappan, Sakthivel; Previs, Michael J; Warshaw, David M 2019. Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems. Proceedings of the National Academy of Sciences of the United States of America, 116 43, 21882-21892Manoharan, Palanikumar; Song, Taejeong; Radzyukevich, Tatiana L; Sadayappan, Sakthivel; Lingrel, Jerry B; Heiny, Judith A 2019. KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration. iScience, 17 , 334-346McNamara, James W; Singh, Rohit R; Sadayappan, Sakthivel 2019. Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. Proceedings of the National Academy of Sciences of the United States of America, 116 24, 11731-11736O'Leary, Thomas S; Snyder, Julia; Sadayappan, Sakthivel; Day, Sharlene M; Previs, Michael J 2019. MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology, 127 , 165-173Sadayappan, Sakthivel 2019. Cardiovascular Leaders Are Made, not Born. Circulation research, 124 4, 484-487Sadayappan, Sakthivel; Gilbert, Richard J 2019. The potential role of neddylation in pre- and postnatal cardiac remodeling. American journal of physiology. Heart and circulatory physiology, 317 2, H276-H278Song, Taejeong; Manoharan, Palanikumar; Millay, Douglas P; Koch, Sheryl E; Rubinstein, Jack; Heiny, Judith A; Sadayappan, Sakthivel 2019. Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation. Skeletal muscle, 9 1, 4Song, Taejeong; Sadayappan, Sakthivel 2019. Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration. Journal of muscle research and cell motility, , Tabish, Ali M; Arif, Mohammed; Song, Taejeong; Elbeck, Zaher; Becker, Richard C; Knöll, Ralph; Sadayappan, Sakthivel 2019. Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy. American journal of physiology. Heart and circulatory physiology, 317 1, H168-H180Toepfer, Christopher N; Wakimoto, Hiroko; Garfinkel, Amanda C; McDonough, Barbara; Liao, Dan; Jiang, Jianming; Tai, Angela C; Gorham, Joshua M; Lunde, Ida G; Lun, Mingyue; Lynch, Thomas L; McNamara, James W; Sadayappan, Sakthivel; Redwood, Charles S; Watkins, Hugh C; Seidman, Jonathan G; Seidman, Christine E 2019. Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Science translational medicine, 11 476, Vagnozzi, Ronald J; Pfleger, Jessica; Sadayappan, Sakthivel 2019. Basic Cardiovascular Sciences Scientific Sessions 2019: Integrative Approaches to Complex Cardiovascular Diseases. Circulation research, 125 10, 924-931Hoffman, Matthew P; Taylor, Erik N; Aninwene, George E; Sadayappan, Sakthivel; Gilbert, Richard J 2018. Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review. Microscopy research and technique, 81 2, 162-170Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang 2018. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nature communications, 9 1, 700Lin, Brian Leei; Li, Amy; Mun, Ji Young; Previs, Michael J; Previs, Samantha Beck; Campbell, Stuart G; Dos Remedios, Cristobal G; Tombe, Pieter de P; Craig, Roger; Warshaw, David M; Sadayappan, Sakthivel 2018. Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner. Scientific reports, 8 1, 2604McNamara, James W; Grimes, Kelly M; Sadayappan, Sakthivel 2018. Basic Cardiovascular Sciences Scientific Sessions 2018. Circulation research, 123 9, 1024-1029McNamara, James W; Sadayappan, Sakthivel 2018. Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology. Archives of biochemistry and biophysics, 660 , 121-128Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 2, Sadayappan, Sakthivel 2018. My Life, My Heart, and My(osin) Binding Protein-C. Circulation research, 122 7, 918-920Smyrnias, Ioannis; Goodwin, Normann; Wachten, Dagmar; Skogestad, Jonas; Aronsen, Jan Magnus; Robinson, Emma L; Demydenko, Kateryna; Segonds-Pichon, Anne; Oxley, David; Sadayappan, Sakthivel; Sipido, Karin; Bootman, Martin D; Roderick, H Llewelyn 2018. Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes. Journal of molecular and cellular cardiology, 117 , 1-18Viswanathan, Shiv Kumar; Puckelwartz, Megan J; Mehta, Ashish; Ramachandra, Chrishan J A; Jagadeesan, Aravindakshan; Fritsche-Danielson, Regina; Bhat, Ratan V; Wong, Philip; Kandoi, Sangeetha; Schwanekamp, Jennifer A; Kuffel, Gina; Pesce, Lorenzo L; Zilliox, Michael J; Durai, U Nalla B; Verma, Rama Shanker; Molokie, Robert E; Suresh, Domodhar P; Khoury, Philip R; Thomas, Annie; Sanagala, Thriveni; Tang, Hak Chiaw; Becker, Richard C; Knöll, Ralph; Shim, Winston; McNally, Elizabeth M; Sadayappan, Sakthivel 2018. Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3?25bpIntronic Deletion in South Asian Descendants. JAMA cardiology, 3 6, 481-488Arif, Mohammed; Pandey, Raghav; Alam, Perwez; Jiang, Shujia; Sadayappan, Sakthivel; Paul, Arghya; Ahmed, Rafeeq P H 2017. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. Journal of molecular medicine (Berlin, Germany), 95 12, 1369-1385Grimes, Kelly M; Barefield, David Y; Kumar, Mohit; McNamara, James W; Weintraub, Susan T; de Tombe, Pieter P; Sadayappan, Sakthivel; Buffenstein, Rochelle 2017. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Archiv : European journal of physiology, 469 12, 1603-1613Lin, Brian Leei; Song, Taejeong; Sadayappan, Sakthivel 2017. Myofilaments: Movers and Rulers of the Sarcomere. Comprehensive Physiology, 7 2, 675-692Lynch, Thomas L; Ismahil, Mohamed Ameen; Jegga, Anil G; Zilliox, Michael J; Troidl, Christian; Prabhu, Sumanth D; Sadayappan, Sakthivel 2017. Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation. Journal of molecular and cellular cardiology, 102 , 83-93Lynch, Thomas L; Kuster, Diederik W D; Gonzalez, Beverly; Balasubramanian, Neelam; Nair, Nandini; Day, Sharlene; Calvino, Jenna E; Tan, Yanli; Liebetrau, Christoph; Troidl, Christian; Hamm, Christian W; Güçlü, Ahmet; McDonough, Barbara; Marian, Ali J; van der Velden, Jolanda; Seidman, Christine E; Huggins, Gordon S; Sadayappan, Sakthivel 2017. Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC. Basic to translational science, 2 2, 122-131Sadayappan, Sakthivel 2017. The Myofilament Field Revisited in the Age of Cellular and Molecular Biology. Circulation research, 121 6, 601-603Sadayappan, Sakthivel 2017. Cardiovascular Early Careers: Past and Present. Circulation research, 121 2, 100-102Sivaguru, Mayandi; Kabir, Mohammad M; Gartia, Manas Ranjan; Biggs, David S C; Sivaguru, Barghav S; Sivaguru, Vignesh A; Fried, Glenn A; Liu, Gang Logan; Sadayappan, Sakthivel; Toussaint, Kimani C 2017. Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy. Journal of microscopy, 267 3, 397-408Tong, Carl W; Dusio, Giuseppina F; Govindan, Suresh; Johnson, Dustin W; Kidwell, David T; De La Rosa, Lisa M; Rosas, Paola C; Liu, Yang; Ebert, Elizabeth; Newell-Rogers, M Karen; Michel, Jeffrey B; Trzeciakowski, Jerome P; Sadayappan, Sakthivel 2017. Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events. The American journal of cardiology, 120 9, 1501-1507Viswanathan, Shiv Kumar; Sanders, Heather K; McNamara, James W; Jagadeesan, Aravindakshan; Jahangir, Arshad; Tajik, A Jamil; Sadayappan, Sakthivel 2017. Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage. PloS one, 12 11, e0187948Barefield, David Y; Lynch, Thomas L; Jagadeesan, Aravindakshan; Sanagala, Thriveni; Sadayappan, Sakthivel 2016. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. Journal of molecular biomarkers & diagnosis, 7 6, Kraker, Jessica; Viswanathan, Shiv Kumar; Knöll, Ralph; Sadayappan, Sakthivel 2016. Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants. Frontiers in physiology, 7 , 499Lipps, Christoph; Nguyen, Jenine H; Pyttel, Lukas; Lynch, Thomas L; Liebetrau, Christoph; Aleshcheva, Ganna; Voss, Sandra; Dörr, Oliver; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Sadayappan, Sakthivel; Troidl, Christian 2016. N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro. Journal of molecular and cellular cardiology, 99 , 47-56Stathopoulou, Konstantina; Wittig, Ilka; Heidler, Juliana; Piasecki, Angelika; Richter, Florian; Diering, Simon; van der Velden, Jolanda; Buck, Friedrich; Donzelli, Sonia; Schröder, Ewald; Wijnker, Paul J M; Voigt, Niels; Dobrev, Dobromir; Sadayappan, Sakthivel; Eschenhagen, Thomas; Carrier, Lucie; Eaton, Philip; Cuello, Friederike 2016. S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 5, 1849-64Taylor, Erik N; Hoffman, Matthew P; Barefield, David Y; Aninwene, George E; Abrishamchi, Aurash D; Lynch, Thomas L; Govindan, Suresh; Osinska, Hanna; Robbins, Jeffrey; Sadayappan, Sakthivel; Gilbert, Richard J 2016. Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C. Journal of the American Heart Association, 5 3, e002836Barefield, David; Kumar, Mohit; Gorham, Joshua; Seidman, Jonathan G; Seidman, Christine E; de Tombe, Pieter P; Sadayappan, Sakthivel 2015. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. Journal of molecular and cellular cardiology, 79 , 234-43Kumar, Mohit; Govindan, Suresh; Zhang, Mengjie; Khairallah, Ramzi J; Martin, Jody L; Sadayappan, Sakthivel; de Tombe, Pieter P 2015. Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation. The Journal of biological chemistry, 290 49, 29241-9Kuster, Diederik W D; Govindan, Suresh; Springer, Tzvia I; Martin, Jody L; Finley, Natosha L; Sadayappan, Sakthivel 2015. A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction. The Journal of biological chemistry, 290 9, 5855-67Lee, Kyounghwan; Harris, Samantha P; Sadayappan, Sakthivel; Craig, Roger 2015. Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. Journal of molecular biology, 427 2, 274-86Lynch, Thomas L; Sivaguru, Mayandi; Velayutham, Murugesan; Cardounel, Arturo J; Michels, Michelle; Barefield, David; Govindan, Suresh; dos Remedios, Cristobal; van der Velden, Jolanda; Sadayappan, Sakthivel 2015. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxidative medicine and cellular longevity, 2015 , 424751Sivaguru, Mayandi; Fried, Glenn; Sivaguru, Barghav S; Sivaguru, Vignesh A; Lu, Xiaochen; Choi, Kyung Hwa; Saif, M Taher A; Lin, Brian; Sadayappan, Sakthivel 2015. Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy. BioTechniques, 59 5, 295-308Thoonen, Robrecht; Giovanni, Shewit; Govindan, Suresh; Lee, Dong I; Wang, Guang-Rong; Calamaras, Timothy D; Takimoto, Eiki; Kass, David A; Sadayappan, Sakthivel; Blanton, Robert M 2015. Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-I? Substrate. Circulation. Heart failure, 8 6, 1115-22Tong, Carl W; Wu, Xin; Liu, Yang; Rosas, Paola C; Sadayappan, Sakthivel; Hudmon, Andy; Muthuchamy, Mariappan; Powers, Patricia A; Valdivia, Héctor H; Moss, Richard L 2015. Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or ?1-Adrenergic Stimulation. Circulation. Heart failure, 8 3, 595-604Barefield, David; Kumar, Mohit; de Tombe, Pieter P; Sadayappan, Sakthivel 2014. Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy. American journal of physiology. Heart and circulatory physiology, 306 6, H807-15Gao, Xianlong; Lin, Brian; Sadayappan, Sakthivel; Patel, Tarun B 2014. Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Molecular pharmacology, 85 2, 357-67Haynes, Premi; Nava, Kristofer E; Lawson, Benjamin A; Chung, Charles S; Mitov, Mihail I; Campbell, Stuart G; Stromberg, Arnold J; Sadayappan, Sakthivel; Bonnell, Mark R; Hoopes, Charles W; Campbell, Kenneth S 2014. Transmural heterogeneity of cellular level power output is reduced in human heart failure. Journal of molecular and cellular cardiology, 72 , 1-8Helms, Adam S; Davis, Frank M; Coleman, David; Bartolone, Sarah N; Glazier, Amelia A; Pagani, Francis; Yob, Jaime M; Sadayappan, Sakthivel; Pedersen, Ellen; Lyons, Robert; Westfall, Margaret V; Jones, Richard; Russell, Mark W; Day, Sharlene M 2014. Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy. Circulation. Cardiovascular genetics, 7 4, 434-43Hoffmann, Jedrzej; Ospelt, Manuel; Troidl, Christian; Voss, Sandra; Liebetrau, Christoph; Kim, Won-Keun; Rolf, Andreas; Wietelmann, Astrid; Braun, Thomas; Troidl, Kerstin; Sadayappan, Sakthivel; Barefield, David; Hamm, Christian; Nef, Holger; Möllmann, Helge 2014. Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction. PloS one, 9 6, e98456Kuster, Diederik W D; Cardenas-Ospina, Adriana; Miller, Lawson; Liebetrau, Christoph; Troidl, Christian; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Pieper, Karen S; Mahaffey, Kenneth W; Kleiman, Neal S; Stuyvers, Bruno D; Marian, Ali J; Sadayappan, Sakthivel 2014. Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury. American journal of physiology. Heart and circulatory physiology, 306 4, H547-56Kuster, Diederik W D; Sadayappan, Sakthivel 2014. MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation. Pflugers Archiv : European journal of physiology, 466 2, 207-13Lynch, Thomas L; Sadayappan, Sakthivel 2014. Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium. Proteomics. Clinical applications, 8 7-8, 569-77Sadayappan, Sakthivel; de Tombe, Pieter P 2014. Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series. Pflugers Archiv : European journal of physiology, 466 2, 195-200Simon, Jillian N; Chowdhury, Shamim A K; Warren, Chad M; Sadayappan, Sakthivel; Wieczorek, David F; Solaro, R John; Wolska, Beata M 2014. Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation. Basic research in cardiology, 109 6, 445Wang, Li; Ji, Xiang; Barefield, David; Sadayappan, Sakthivel; Kawai, Masakata 2014. Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner. Biophysical journal, 106 5, 1112-22Wang, Li; Sadayappan, Sakthivel; Kawai, Masakata 2014. Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner. PloS one, 9 11, e113417Wilson, Kristin; Guggilam, Anuradha; West, T Aaron; Zhang, Xiaojin; Trask, Aaron J; Cismowski, Mary J; de Tombe, Pieter; Sadayappan, Sakthivel; Lucchesi, Pamela A 2014. Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure. American journal of physiology. Heart and circulatory physiology, 307 11, H1605-17Witayavanitkul, Namthip; Ait Mou, Younss; Kuster, Diederik W D; Khairallah, Ramzi J; Sarkey, Jason; Govindan, Suresh; Chen, Xin; Ge, Ying; Rajan, Sudarsan; Wieczorek, David F; Irving, Thomas; Westfall, Margaret V; de Tombe, Pieter P; Sadayappan, Sakthivel 2014. Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. The Journal of biological chemistry, 289 13, 8818-27Govindan, Suresh; Kuster, Diederik Wd; Lin, Brian; Kahn, Daniel J; Jeske, Walter P; Walenga, Jeanine M; Leya, Fred; Hoppensteadt, Debra; Fareed, Jawed; Sadayappan, Sakthivel 2013. Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. American journal of cardiovascular disease, 3 2, 60-70Guggilam, Anuradha; Hutchinson, Kirk R; West, T Aaron; Kelly, Amy P; Galantowicz, Maarten L; Davidoff, Amy J; Sadayappan, Sakthivel; Lucchesi, Pamela A 2013. In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure. Journal of molecular and cellular cardiology, 57 , 47-58Guillory, Ashley N; Yin, Xing; Wijaya, Cori S; Diaz Diaz, Andrea C; Rababa'h, Abeer; Singh, Sonal; Atrooz, Fatin; Sadayappan, Sakthivel; McConnell, Bradley K 2013. Enhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade. PloS one, 8 9, e74784Hwang, Hyosook; Robinson, Dustin; Rogers, Julie B; Stevenson, Tamara K; Lang, Sarah E; Sadayappan, Sakthivel; Day, Sharlene M; Sivaramakrishnan, Sivaraj; Westfall, Margaret V 2013. Agonist activated PKC?II translocation and modulation of cardiac myocyte contractile function. Scientific reports, 3 , 1971Jin, Chun Zi; Jang, Ji Hyun; Kim, Hae Jin; Wang, Yue; Hwang, In-Chang; Sadayappan, Sakthivel; Park, Byung Mun; Kim, Suhn Hee; Jin, Zhe Hu; Seo, Eun Yeong; Kim, Kyung-Hee; Kim, Yong-Jin; Kim, Sung Joon; Zhang, Yin Hua 2013. Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart. Journal of molecular and cellular cardiology, 60 , 107-15Khairallah, Ramzi J; Sadayappan, Sakthivel 2013. Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach. Proteomics, 13 22, 3245-6Kuster, Diederik W D; Barefield, David; Govindan, Suresh; Sadayappan, Sakthivel 2013. A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. Journal of visualized experiments : JoVE, 78, Kuster, Diederik W D; Sequeira, Vasco; Najafi, Aref; Boontje, Nicky M; Wijnker, Paul J M; Witjas-Paalberends, E Rosalie; Marston, Steven B; Dos Remedios, Cristobal G; Carrier, Lucie; Demmers, Jeroen A A; Redwood, Charles; Sadayappan, Sakthivel; van der Velden, Jolanda 2013. GSK3? phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication. Circulation research, 112 4, 633-9Lin, Brian; Govindan, Suresh; Lee, Kyounghwan; Zhao, Piming; Han, Renzhi; Runte, K Elisabeth; Craig, Roger; Palmer, Bradley M; Sadayappan, Sakthivel 2013. Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function. PloS one, 8 7, e69671Sequeira, Vasco; Wijnker, Paul J M; Nijenkamp, Louise L A M; Kuster, Diederik W D; Najafi, Aref; Witjas-Paalberends, E Rosalie; Regan, Jessica A; Boontje, Nicky; Ten Cate, Folkert J; Germans, Tjeerd; Carrier, Lucie; Sadayappan, Sakthivel; van Slegtenhorst, Marjon A; Zaremba, Ruud; Foster, D Brian; Murphy, Anne M; Poggesi, Corrado; Dos Remedios, Cris; Stienen, Ger J M; Ho, Carolyn Y; Michels, Michelle; van der Velden, Jolanda 2013. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circulation research, 112 11, 1491-505Dirkx, Ellen; Cazorla, Olivier; Schwenk, Robert W; Lorenzen-Schmidt, Ilka; Sadayappan, Sakthivel; Van Lint, Johan; Carrier, Lucie; van Eys, Guillaume J J M; Glatz, Jan F C; Luiken, Joost J F P 2012. Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315. American journal of physiology. Heart and circulatory physiology, 303 3, H323-31Govindan, Suresh; McElligott, Andrew; Muthusamy, Saminathan; Nair, Nandini; Barefield, David; Martin, Jody L; Gongora, Enrique; Greis, Kenneth D; Luther, Pradeep K; Winegrad, Saul; Henderson, Kyle K; Sadayappan, Sakthivel 2012. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. Journal of molecular and cellular cardiology, 52 1, 154-64Govindan, Suresh; Sarkey, Jason; Ji, Xiang; Sundaresan, Nagalingam R; Gupta, Mahesh P; de Tombe, Pieter P; Sadayappan, Sakthivel 2012. Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. Journal of muscle research and cell motility, 33 1, 17-30Hinken, Aaron C; Hanft, Laurin M; Scruggs, Sarah B; Sadayappan, Sakthivel; Robbins, Jeffery; Solaro, R John; McDonald, Kerry S 2012. Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. Journal of muscle research and cell motility, 33 6, 439-48Howarth, Jack W; Ramisetti, Srinivas; Nolan, Kristof; Sadayappan, Sakthivel; Rosevear, Paul R 2012. Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain. The Journal of biological chemistry, 287 11, 8254-62Hwang, Hyosook; Robinson, Dustin A; Stevenson, Tamara K; Wu, Helen C; Kampert, Sarah E; Pagani, Francis D; Dyke, D Brad; Martin, Jody L; Sadayappan, Sakthival; Day, Sharlene M; Westfall, Margaret V 2012. PKC?II modulation of myocyte contractile performance. Journal of molecular and cellular cardiology, 53 2, 176-86Sadayappan, Sakthivel 2012. Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury. Biomarkers in medicine, 6 1, 69-72Sadayappan, Sakthivel; de Tombe, Pieter P 2012. Cardiac myosin binding protein-C: redefining its structure and function. Biophysical reviews, 4 2, 93-106van Dijk, Sabine J; Paalberends, E Rosalie; Najafi, Aref; Michels, Michelle; Sadayappan, Sakthivel; Carrier, Lucie; Boontje, Nicky M; Kuster, Diederik W D; van Slegtenhorst, Marjon; Dooijes, Dennis; dos Remedios, Cris; ten Cate, Folkert J; Stienen, Ger J M; van der Velden, Jolanda 2012. Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart failure, 5 1, 36-46Verma, Suresh Kumar; Krishnamurthy, Prasanna; Barefield, David; Singh, Neha; Gupta, Rajesh; Lambers, Erin; Thal, Melissa; Mackie, Alexander; Hoxha, Eneda; Ramirez, Veronica; Qin, Gangjian; Sadayappan, Sakthivel; Ghosh, Asish K; Kishore, Raj 2012. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B. Circulation, 126 4, 418-29Weith, Abbey; Sadayappan, Sakthivel; Gulick, James; Previs, Michael J; Vanburen, Peter; Robbins, Jeffrey; Warshaw, David M 2012. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. Journal of molecular and cellular cardiology, 52 1, 219-27Cuello, Friederike; Bardswell, Sonya C; Haworth, Robert S; Ehler, Elisabeth; Sadayappan, Sakthivel; Kentish, Jonathan C; Avkiran, Metin 2011. Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. The Journal of biological chemistry, 286 7, 5300-10Palmer, Bradley M; Sadayappan, Sakthivel; Wang, Yuan; Weith, Abbey E; Previs, Michael J; Bekyarova, Tanya; Irving, Thomas C; Robbins, Jeffrey; Maughan, David W 2011. Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical journal, 101 7, 1661-9Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey 2011. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research, 109 2, 141-50Bardswell, Sonya C; Cuello, Friederike; Rowland, Alexandra J; Sadayappan, Sakthivel; Robbins, Jeffrey; Gautel, Mathias; Walker, Jeffery W; Kentish, Jonathan C; Avkiran, Metin 2010. Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. The Journal of biological chemistry, 285 8, 5674-82Barefield, David; Sadayappan, Sakthivel 2010. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. Journal of molecular and cellular cardiology, 48 5, 866-75Copeland, O'Neal; Sadayappan, Sakthivel; Messer, Andrew E; Steinen, Ger J M; van der Velden, Jolanda; Marston, Steven B 2010. Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle. Journal of molecular and cellular cardiology, 49 6, 1003-11Senapathy, Periannan; Bhasi, Ashwini; Mattox, Jeffrey; Dhandapany, Perundurai S; Sadayappan, Sakthivel 2010. Targeted genome-wide enrichment of functional regions. PloS one, 5 6, e11138Dhandapany, Perundurai S; Sadayappan, Sakthivel; Xue, Yali; Powell, Gareth T; Rani, Deepa Selvi; Nallari, Prathiba; Rai, Taranjit Singh; Khullar, Madhu; Soares, Pedro; Bahl, Ajay; Tharkan, Jagan Mohan; Vaideeswar, Pradeep; Rathinavel, Andiappan; Narasimhan, Calambur; Ayapati, Dharma Rakshak; Ayub, Qasim; Mehdi, S Qasim; Oppenheimer, Stephen; Richards, Martin B; Price, Alkes L; Patterson, Nick; Reich, David; Singh, Lalji; Tyler-Smith, Chris; Thangaraj, Kumarasamy 2009. A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nature genetics, 41 2, 187-91Nicolaou, Persoulla; Rodriguez, Patricia; Ren, Xiaoping; Zhou, Xiaoyang; Qian, Jiang; Sadayappan, Sakthivel; Mitton, Bryan; Pathak, Anand; Robbins, Jeffrey; Hajjar, Roger J; Jones, Keith; Kranias, Evangelia G 2009. Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circulation research, 104 8, 1012-20Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey 2009. Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation, 119 9, 1253-62Sadayappan, Sakthivel; Finley, Natosha; Howarth, Jack W; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Rosevear, Paul R; Robbins, Jeffrey 2008. Role of the acidic N' region of cardiac troponin I in regulating myocardial function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22 4, 1246-57Sadayappan, Sakthivel; Robbins, Jeffrey 2008. The death of transcriptional chauvinism in the control and regulation of cardiac contractility. Annals of the New York Academy of Sciences, 1123 , 1-9Dhandapany, Perundurai S; Sadayappan, Sakthivel; Vanniarajan, Ayyasamy; Karthikeyan, Bose; Nagaraj, Chandran; Gowrishankar, Kalpana; Selvam, Govindan Sadasivam; Singh, Lalji; Thangaraj, Kumarasamy 2007. Novel mitochondrial DNA mutations implicated in Noonan syndrome. International journal of cardiology, 120 2, 284-5Krenz, Maike; Sadayappan, Sakthivel; Osinska, Hanna E; Henry, Jeffrey A; Beck, Samantha; Warshaw, David M; Robbins, Jeffrey 2007. Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. The Journal of biological chemistry, 282 33, 24057-64Nagayama, Takahiro; Takimoto, Eiki; Sadayappan, Sakthivel; Mudd, James O; Seidman, J G; Robbins, Jeffrey; Kass, David A 2007. Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation, 116 21, 2399-408Yasuda, So-ichiro; Coutu, Pierre; Sadayappan, Sakthivel; Robbins, Jeffrey; Metzger, Joseph M 2007. Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circulation research, 101 4, 377-86Annapoorani, Ponnambalam; Dhandapany, Perundurai S; Sadayappan, Sakthivel; Ramasamy, Subbiah; Rathinavel, Andiappan; Selvam, Govindan Sadasivam 2006. Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients. Atherosclerosis, 186 1, 173-6Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey 2006. Cardiac myosin binding protein C phosphorylation is cardioprotective. Proceedings of the National Academy of Sciences of the United States of America, 103 45, 16918-23Wang, Hao; Grant, Jennifer E; Doede, Christopher M; Sadayappan, Sakthivel; Robbins, Jeffrey; Walker, Jeffery W 2006. PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. Journal of molecular and cellular cardiology, 41 5, 823-33Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Martin, Lisa A; Hahn, Harvey S; Dorn, Gerald W; Klevitsky, Raisa; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey 2005. Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circulation research, 97 11, 1156-63
Research InterestsThe long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease.
Peer Reviewed Publications Becker, Richard C; Owens, A Phillip; Sadayappan, Sakthivel 2020. Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy. Journal of thrombosis and thrombolysis, 49 2, 177-183Becker, Richard C; Sadayappan, Sakthivel 2020. Designing Human In Vitro Models for Drug Development. Journal of the American College of Cardiology, 75 6, 587-589Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J 2020. Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation. JACC. Basic to translational science, 5 2, 109-122Vagnozzi, Ronald J; Maillet, Marjorie; Sargent, Michelle A; Khalil, Hadi; Johansen, Anne Katrine Z; Schwanekamp, Jennifer A; York, Allen J; Huang, Vincent; Nahrendorf, Matthias; Sadayappan, Sakthivel; Molkentin, Jeffery D 2020. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature, 577 7790, 405-409Alam, Perwez; Haile, Bereket; Arif, Mohammed; Pandey, Raghav; Rokvic, Miso; Nieman, Michelle; Maliken, Bryan D; Paul, Arghya; Wang, Yi-Gang; Sadayappan, Sakthivel; Ahmed, Rafeeq P H; Kanisicak, Onur 2019. Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction. Journal of the American Heart Association, 8 15, e012089Arif, Mohammed; Sadayappan, Sakthivel; Becker, Richard C; Martin, Lisa J; Urbina, Elaine M 2019. Epigenetic modification: a regulatory mechanism in essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 42 8, 1099-1113Barefield, David Y; McNamara, James W; Lynch, Thomas L; Kuster, Diederik W D; Govindan, Suresh; Haar, Lauren; Wang, Yang; Taylor, Erik N; Lorenz, John N; Nieman, Michelle L; Zhu, Guangshuo; Luther, Pradeep K; Varró, Andras; Dobrev, Dobromir; Ai, Xun; Janssen, Paul M L; Kass, David A; Jones, Walter Keith; Gilbert, Richard J; Sadayappan, Sakthivel 2019. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. Journal of molecular and cellular cardiology, 129 , 236-246Becker, Richard C; Cotarlan, Vlad; Sadayappan, Sakthi 2019. The rapid proliferation of solicited content online journals: a quest to disseminate knowledge? Journal of thrombosis and thrombolysis, 47 3, 337-344Boyer, Justin G; Prasad, Vikram; Song, Taejeong; Lee, Donghoon; Fu, Xing; Grimes, Kelly M; Sargent, Michelle A; Sadayappan, Sakthivel; Molkentin, Jeffery D 2019. ERK1/2 signaling induces skeletal muscle slow fiber-type switching and reduces muscular dystrophy disease severity. JCI insight, 5 , Goh, Qingnian; Song, Taejeong; Petrany, Michael J; Cramer, Alyssa Aw; Sun, Chengyi; Sadayappan, Sakthivel; Lee, Se-Jin; Millay, Douglas P 2019. Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle. eLife, 8 , Ikeda, Shohei; Mizushima, Wataru; Sciarretta, Sebastiano; Abdellatif, Maha; Zhai, Peiyong; Mukai, Risa; Fefelova, Nadezhda; Oka, Shin-Ichi; Nakamura, Michinari; Del Re, Dominic P; Farrance, Iain; Park, Ji Yeon; Tian, Bin; Xie, Lai-Hua; Kumar, Mohit; Hsu, Chiao-Po; Sadayappan, Sakthivel; Shimokawa, Hiroaki; Lim, Dae-Sik; Sadoshima, Junichi 2019. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circulation research, 124 2, 292-305Kuster, Diederik W D; Lynch, Thomas L; Barefield, David Y; Sivaguru, Mayandi; Kuffel, Gina; Zilliox, Michael J; Lee, Kyoung Hwan; Craig, Roger; Namakkal-Soorappan, Rajasekaran; Sadayappan, Sakthivel 2019. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy. Cardiovascular research, 115 14, 1986-1997Li, Amy; Nelson, Shane R; Rahmanseresht, Sheema; Braet, Filip; Cornachione, Anabelle S; Previs, Samantha Beck; O'Leary, Thomas S; McNamara, James W; Rassier, Dilson E; Sadayappan, Sakthivel; Previs, Michael J; Warshaw, David M 2019. Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems. Proceedings of the National Academy of Sciences of the United States of America, 116 43, 21882-21892Manoharan, Palanikumar; Song, Taejeong; Radzyukevich, Tatiana L; Sadayappan, Sakthivel; Lingrel, Jerry B; Heiny, Judith A 2019. KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration. iScience, 17 , 334-346McNamara, James W; Singh, Rohit R; Sadayappan, Sakthivel 2019. Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. Proceedings of the National Academy of Sciences of the United States of America, 116 24, 11731-11736O'Leary, Thomas S; Snyder, Julia; Sadayappan, Sakthivel; Day, Sharlene M; Previs, Michael J 2019. MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology, 127 , 165-173Sadayappan, Sakthivel 2019. Cardiovascular Leaders Are Made, not Born. Circulation research, 124 4, 484-487Sadayappan, Sakthivel; Gilbert, Richard J 2019. The potential role of neddylation in pre- and postnatal cardiac remodeling. American journal of physiology. Heart and circulatory physiology, 317 2, H276-H278Song, Taejeong; Manoharan, Palanikumar; Millay, Douglas P; Koch, Sheryl E; Rubinstein, Jack; Heiny, Judith A; Sadayappan, Sakthivel 2019. Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation. Skeletal muscle, 9 1, 4Song, Taejeong; Sadayappan, Sakthivel 2019. Featured characteristics and pivotal roles of satellite cells in skeletal muscle regeneration. Journal of muscle research and cell motility, , Tabish, Ali M; Arif, Mohammed; Song, Taejeong; Elbeck, Zaher; Becker, Richard C; Knöll, Ralph; Sadayappan, Sakthivel 2019. Association of intronic DNA methylation and hydroxymethylation alterations in the epigenetic etiology of dilated cardiomyopathy. American journal of physiology. Heart and circulatory physiology, 317 1, H168-H180Toepfer, Christopher N; Wakimoto, Hiroko; Garfinkel, Amanda C; McDonough, Barbara; Liao, Dan; Jiang, Jianming; Tai, Angela C; Gorham, Joshua M; Lunde, Ida G; Lun, Mingyue; Lynch, Thomas L; McNamara, James W; Sadayappan, Sakthivel; Redwood, Charles S; Watkins, Hugh C; Seidman, Jonathan G; Seidman, Christine E 2019. Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Science translational medicine, 11 476, Vagnozzi, Ronald J; Pfleger, Jessica; Sadayappan, Sakthivel 2019. Basic Cardiovascular Sciences Scientific Sessions 2019: Integrative Approaches to Complex Cardiovascular Diseases. Circulation research, 125 10, 924-931Hoffman, Matthew P; Taylor, Erik N; Aninwene, George E; Sadayappan, Sakthivel; Gilbert, Richard J 2018. Assessing the multiscale architecture of muscular tissue with Q-space magnetic resonance imaging: Review. Microscopy research and technique, 81 2, 162-170Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang 2018. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nature communications, 9 1, 700Lin, Brian Leei; Li, Amy; Mun, Ji Young; Previs, Michael J; Previs, Samantha Beck; Campbell, Stuart G; Dos Remedios, Cristobal G; Tombe, Pieter de P; Craig, Roger; Warshaw, David M; Sadayappan, Sakthivel 2018. Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner. Scientific reports, 8 1, 2604McNamara, James W; Grimes, Kelly M; Sadayappan, Sakthivel 2018. Basic Cardiovascular Sciences Scientific Sessions 2018. Circulation research, 123 9, 1024-1029McNamara, James W; Sadayappan, Sakthivel 2018. Skeletal myosin binding protein-C: An increasingly important regulator of striated muscle physiology. Archives of biochemistry and biophysics, 660 , 121-128Robbins, Nathan; Gilbert, Mark; Kumar, Mohit; McNamara, James W; Daly, Patrick; Koch, Sheryl E; Conway, Ginger; Effat, Mohamed; Woo, Jessica G; Sadayappan, Sakthivel; Rubinstein, Jack 2018. Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro. Journal of the American Heart Association, 7 2, Sadayappan, Sakthivel 2018. My Life, My Heart, and My(osin) Binding Protein-C. Circulation research, 122 7, 918-920Smyrnias, Ioannis; Goodwin, Normann; Wachten, Dagmar; Skogestad, Jonas; Aronsen, Jan Magnus; Robinson, Emma L; Demydenko, Kateryna; Segonds-Pichon, Anne; Oxley, David; Sadayappan, Sakthivel; Sipido, Karin; Bootman, Martin D; Roderick, H Llewelyn 2018. Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes. Journal of molecular and cellular cardiology, 117 , 1-18Viswanathan, Shiv Kumar; Puckelwartz, Megan J; Mehta, Ashish; Ramachandra, Chrishan J A; Jagadeesan, Aravindakshan; Fritsche-Danielson, Regina; Bhat, Ratan V; Wong, Philip; Kandoi, Sangeetha; Schwanekamp, Jennifer A; Kuffel, Gina; Pesce, Lorenzo L; Zilliox, Michael J; Durai, U Nalla B; Verma, Rama Shanker; Molokie, Robert E; Suresh, Domodhar P; Khoury, Philip R; Thomas, Annie; Sanagala, Thriveni; Tang, Hak Chiaw; Becker, Richard C; Knöll, Ralph; Shim, Winston; McNally, Elizabeth M; Sadayappan, Sakthivel 2018. Association of Cardiomyopathy With MYBPC3 D389V and MYBPC3?25bpIntronic Deletion in South Asian Descendants. JAMA cardiology, 3 6, 481-488Arif, Mohammed; Pandey, Raghav; Alam, Perwez; Jiang, Shujia; Sadayappan, Sakthivel; Paul, Arghya; Ahmed, Rafeeq P H 2017. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. Journal of molecular medicine (Berlin, Germany), 95 12, 1369-1385Grimes, Kelly M; Barefield, David Y; Kumar, Mohit; McNamara, James W; Weintraub, Susan T; de Tombe, Pieter P; Sadayappan, Sakthivel; Buffenstein, Rochelle 2017. The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent. Pflugers Archiv : European journal of physiology, 469 12, 1603-1613Lin, Brian Leei; Song, Taejeong; Sadayappan, Sakthivel 2017. Myofilaments: Movers and Rulers of the Sarcomere. Comprehensive Physiology, 7 2, 675-692Lynch, Thomas L; Ismahil, Mohamed Ameen; Jegga, Anil G; Zilliox, Michael J; Troidl, Christian; Prabhu, Sumanth D; Sadayappan, Sakthivel 2017. Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation. Journal of molecular and cellular cardiology, 102 , 83-93Lynch, Thomas L; Kuster, Diederik W D; Gonzalez, Beverly; Balasubramanian, Neelam; Nair, Nandini; Day, Sharlene; Calvino, Jenna E; Tan, Yanli; Liebetrau, Christoph; Troidl, Christian; Hamm, Christian W; Güçlü, Ahmet; McDonough, Barbara; Marian, Ali J; van der Velden, Jolanda; Seidman, Christine E; Huggins, Gordon S; Sadayappan, Sakthivel 2017. Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome. JACC. Basic to translational science, 2 2, 122-131Sadayappan, Sakthivel 2017. The Myofilament Field Revisited in the Age of Cellular and Molecular Biology. Circulation research, 121 6, 601-603Sadayappan, Sakthivel 2017. Cardiovascular Early Careers: Past and Present. Circulation research, 121 2, 100-102Sivaguru, Mayandi; Kabir, Mohammad M; Gartia, Manas Ranjan; Biggs, David S C; Sivaguru, Barghav S; Sivaguru, Vignesh A; Fried, Glenn A; Liu, Gang Logan; Sadayappan, Sakthivel; Toussaint, Kimani C 2017. Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy. Journal of microscopy, 267 3, 397-408Tong, Carl W; Dusio, Giuseppina F; Govindan, Suresh; Johnson, Dustin W; Kidwell, David T; De La Rosa, Lisa M; Rosas, Paola C; Liu, Yang; Ebert, Elizabeth; Newell-Rogers, M Karen; Michel, Jeffrey B; Trzeciakowski, Jerome P; Sadayappan, Sakthivel 2017. Usefulness of Released Cardiac Myosin Binding Protein-C as a Predictor of Cardiovascular Events. The American journal of cardiology, 120 9, 1501-1507Viswanathan, Shiv Kumar; Sanders, Heather K; McNamara, James W; Jagadeesan, Aravindakshan; Jahangir, Arshad; Tajik, A Jamil; Sadayappan, Sakthivel 2017. Hypertrophic cardiomyopathy clinical phenotype is independent of gene mutation and mutation dosage. PloS one, 12 11, e0187948Barefield, David Y; Lynch, Thomas L; Jagadeesan, Aravindakshan; Sanagala, Thriveni; Sadayappan, Sakthivel 2016. High-Throughput Diagnostic Assay for a Highly Prevalent Cardiomyopathy-Associated MYBPC3 Variant. Journal of molecular biomarkers & diagnosis, 7 6, Kraker, Jessica; Viswanathan, Shiv Kumar; Knöll, Ralph; Sadayappan, Sakthivel 2016. Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian Descendants. Frontiers in physiology, 7 , 499Lipps, Christoph; Nguyen, Jenine H; Pyttel, Lukas; Lynch, Thomas L; Liebetrau, Christoph; Aleshcheva, Ganna; Voss, Sandra; Dörr, Oliver; Nef, Holger M; Möllmann, Helge; Hamm, Christian W; Sadayappan, Sakthivel; Troidl, Christian 2016. N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro. Journal of molecular and cellular cardiology, 99 , 47-56Stathopoulou, Konstantina; Wittig, Ilka; Heidler, Juliana; Piasecki, Angelika; Richter, Florian; Diering, Simon; van der Velden, Jolanda; Buck, Friedrich; Donzelli, Sonia; Schröder, Ewald; Wijnker, Paul J M; Voigt, Niels; Dobrev, Dobromir; Sadayappan, Sakthivel; Eschenhagen, Thomas; Carrier, Lucie; Eaton, Philip; Cuello, Friederike 2016. S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30 5, 1849-64Taylor, Erik N; Hoffman, Matthew P; Barefield, David Y; Aninwene, George E; Abrishamchi, Aurash D; Lynch, Thomas L; Govindan, Suresh; Osinska, Hanna; Robbins, Jeffrey; Sadayappan, Sakthivel; Gilbert, Richard J 2016. Alterations in Multi-Scale Cardiac Architecture in Association With Phosphorylation of Myosin Binding Protein-C. Journal of the American Heart Association, 5 3, e002836Barefield, David; Kumar, Mohit; Gorham, Joshua; Seidman, Jonathan G; Seidman, Christine E; de Tombe, Pieter P; Sadayappan, Sakthivel 2015. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. Journal of molecular and cellular cardiology, 79 , 234-43Kumar, Mohit; Govindan, Suresh; Zhang, Mengjie; Khairallah, Ramzi J; Martin, Jody L; Sadayappan, Sakthivel; de Tombe, Pieter P 2015. Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation. The Journal of biological chemistry, 290 49, 29241-9Kuster, Diederik W D; Govindan, Suresh; Springer, Tzvia I; Martin, Jody L; Finley, Natosha L; Sadayappan, Sakthivel 2015. A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction. The Journal of biological chemistry, 290 9, 5855-67Lee, Kyounghwan; Harris, Samantha P; Sadayappan, Sakthivel; Craig, Roger 2015. Orientation of myosin binding protein C in the cardiac muscle sarcomere determined by domain-specific immuno-EM. Journal of molecular biology, 427 2, 274-86Lynch, Thomas L; Sivaguru, Mayandi; Velayutham, Murugesan; Cardounel, Arturo J; Michels, Michelle; Barefield, David; Govindan, Suresh; dos Remedios, Cristobal; van der Velden, Jolanda; Sadayappan, Sakthivel 2015. Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxidative medicine and cellular longevity, 2015 , 424751Sivaguru, Mayandi; Fried, Glenn; Sivaguru, Barghav S; Sivaguru, Vignesh A; Lu, Xiaochen; Choi, Kyung Hwa; Saif, M Taher A; Lin, Brian; Sadayappan, Sakthivel 2015. Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy. 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Heart and circulatory physiology, 306 6, H807-15Gao, Xianlong; Lin, Brian; Sadayappan, Sakthivel; Patel, Tarun B 2014. Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Molecular pharmacology, 85 2, 357-67Haynes, Premi; Nava, Kristofer E; Lawson, Benjamin A; Chung, Charles S; Mitov, Mihail I; Campbell, Stuart G; Stromberg, Arnold J; Sadayappan, Sakthivel; Bonnell, Mark R; Hoopes, Charles W; Campbell, Kenneth S 2014. Transmural heterogeneity of cellular level power output is reduced in human heart failure. Journal of molecular and cellular cardiology, 72 , 1-8Helms, Adam S; Davis, Frank M; Coleman, David; Bartolone, Sarah N; Glazier, Amelia A; Pagani, Francis; Yob, Jaime M; Sadayappan, Sakthivel; Pedersen, Ellen; Lyons, Robert; Westfall, Margaret V; Jones, Richard; Russell, Mark W; Day, Sharlene M 2014. Sarcomere mutation-specific expression patterns in human hypertrophic cardiomyopathy. Circulation. 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MYBPC3's alternate ending: consequences and therapeutic implications of a highly prevalent 25 bp deletion mutation. Pflugers Archiv : European journal of physiology, 466 2, 207-13Lynch, Thomas L; Sadayappan, Sakthivel 2014. Surviving the infarct: A profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium. Proteomics. Clinical applications, 8 7-8, 569-77Sadayappan, Sakthivel; de Tombe, Pieter P 2014. Cardiac myosin binding protein-C as a central target of cardiac sarcomere signaling: a special mini review series. Pflugers Archiv : European journal of physiology, 466 2, 195-200Simon, Jillian N; Chowdhury, Shamim A K; Warren, Chad M; Sadayappan, Sakthivel; Wieczorek, David F; Solaro, R John; Wolska, Beata M 2014. Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation. Basic research in cardiology, 109 6, 445Wang, Li; Ji, Xiang; Barefield, David; Sadayappan, Sakthivel; Kawai, Masakata 2014. Phosphorylation of cMyBP-C affects contractile mechanisms in a site-specific manner. Biophysical journal, 106 5, 1112-22Wang, Li; Sadayappan, Sakthivel; Kawai, Masakata 2014. Cardiac myosin binding protein C phosphorylation affects cross-bridge cycle's elementary steps in a site-specific manner. PloS one, 9 11, e113417Wilson, Kristin; Guggilam, Anuradha; West, T Aaron; Zhang, Xiaojin; Trask, Aaron J; Cismowski, Mary J; de Tombe, Pieter; Sadayappan, Sakthivel; Lucchesi, Pamela A 2014. Effects of a myofilament calcium sensitizer on left ventricular systolic and diastolic function in rats with volume overload heart failure. American journal of physiology. Heart and circulatory physiology, 307 11, H1605-17Witayavanitkul, Namthip; Ait Mou, Younss; Kuster, Diederik W D; Khairallah, Ramzi J; Sarkey, Jason; Govindan, Suresh; Chen, Xin; Ge, Ying; Rajan, Sudarsan; Wieczorek, David F; Irving, Thomas; Westfall, Margaret V; de Tombe, Pieter P; Sadayappan, Sakthivel 2014. Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. The Journal of biological chemistry, 289 13, 8818-27Govindan, Suresh; Kuster, Diederik Wd; Lin, Brian; Kahn, Daniel J; Jeske, Walter P; Walenga, Jeanine M; Leya, Fred; Hoppensteadt, Debra; Fareed, Jawed; Sadayappan, Sakthivel 2013. Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. American journal of cardiovascular disease, 3 2, 60-70Guggilam, Anuradha; Hutchinson, Kirk R; West, T Aaron; Kelly, Amy P; Galantowicz, Maarten L; Davidoff, Amy J; Sadayappan, Sakthivel; Lucchesi, Pamela A 2013. In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure. Journal of molecular and cellular cardiology, 57 , 47-58Guillory, Ashley N; Yin, Xing; Wijaya, Cori S; Diaz Diaz, Andrea C; Rababa'h, Abeer; Singh, Sonal; Atrooz, Fatin; Sadayappan, Sakthivel; McConnell, Bradley K 2013. Enhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade. PloS one, 8 9, e74784Hwang, Hyosook; Robinson, Dustin; Rogers, Julie B; Stevenson, Tamara K; Lang, Sarah E; Sadayappan, Sakthivel; Day, Sharlene M; Sivaramakrishnan, Sivaraj; Westfall, Margaret V 2013. Agonist activated PKC?II translocation and modulation of cardiac myocyte contractile function. Scientific reports, 3 , 1971Jin, Chun Zi; Jang, Ji Hyun; Kim, Hae Jin; Wang, Yue; Hwang, In-Chang; Sadayappan, Sakthivel; Park, Byung Mun; Kim, Suhn Hee; Jin, Zhe Hu; Seo, Eun Yeong; Kim, Kyung-Hee; Kim, Yong-Jin; Kim, Sung Joon; Zhang, Yin Hua 2013. Myofilament Ca2+ desensitization mediates positive lusitropic effect of neuronal nitric oxide synthase in left ventricular myocytes from murine hypertensive heart. Journal of molecular and cellular cardiology, 60 , 107-15Khairallah, Ramzi J; Sadayappan, Sakthivel 2013. Finding the missing link: disulfide-containing proteins via a high-throughput proteomics approach. Proteomics, 13 22, 3245-6Kuster, Diederik W D; Barefield, David; Govindan, Suresh; Sadayappan, Sakthivel 2013. A sensitive and specific quantitation method for determination of serum cardiac myosin binding protein-C by electrochemiluminescence immunoassay. 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PloS one, 8 7, e69671Sequeira, Vasco; Wijnker, Paul J M; Nijenkamp, Louise L A M; Kuster, Diederik W D; Najafi, Aref; Witjas-Paalberends, E Rosalie; Regan, Jessica A; Boontje, Nicky; Ten Cate, Folkert J; Germans, Tjeerd; Carrier, Lucie; Sadayappan, Sakthivel; van Slegtenhorst, Marjon A; Zaremba, Ruud; Foster, D Brian; Murphy, Anne M; Poggesi, Corrado; Dos Remedios, Cris; Stienen, Ger J M; Ho, Carolyn Y; Michels, Michelle; van der Velden, Jolanda 2013. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations. Circulation research, 112 11, 1491-505Dirkx, Ellen; Cazorla, Olivier; Schwenk, Robert W; Lorenzen-Schmidt, Ilka; Sadayappan, Sakthivel; Van Lint, Johan; Carrier, Lucie; van Eys, Guillaume J J M; Glatz, Jan F C; Luiken, Joost J F P 2012. Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315. American journal of physiology. Heart and circulatory physiology, 303 3, H323-31Govindan, Suresh; McElligott, Andrew; Muthusamy, Saminathan; Nair, Nandini; Barefield, David; Martin, Jody L; Gongora, Enrique; Greis, Kenneth D; Luther, Pradeep K; Winegrad, Saul; Henderson, Kyle K; Sadayappan, Sakthivel 2012. Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction. Journal of molecular and cellular cardiology, 52 1, 154-64Govindan, Suresh; Sarkey, Jason; Ji, Xiang; Sundaresan, Nagalingam R; Gupta, Mahesh P; de Tombe, Pieter P; Sadayappan, Sakthivel 2012. Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. Journal of muscle research and cell motility, 33 1, 17-30Hinken, Aaron C; Hanft, Laurin M; Scruggs, Sarah B; Sadayappan, Sakthivel; Robbins, Jeffery; Solaro, R John; McDonald, Kerry S 2012. Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. Journal of muscle research and cell motility, 33 6, 439-48Howarth, Jack W; Ramisetti, Srinivas; Nolan, Kristof; Sadayappan, Sakthivel; Rosevear, Paul R 2012. Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain. The Journal of biological chemistry, 287 11, 8254-62Hwang, Hyosook; Robinson, Dustin A; Stevenson, Tamara K; Wu, Helen C; Kampert, Sarah E; Pagani, Francis D; Dyke, D Brad; Martin, Jody L; Sadayappan, Sakthival; Day, Sharlene M; Westfall, Margaret V 2012. PKC?II modulation of myocyte contractile performance. Journal of molecular and cellular cardiology, 53 2, 176-86Sadayappan, Sakthivel 2012. Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury. Biomarkers in medicine, 6 1, 69-72Sadayappan, Sakthivel; de Tombe, Pieter P 2012. Cardiac myosin binding protein-C: redefining its structure and function. Biophysical reviews, 4 2, 93-106van Dijk, Sabine J; Paalberends, E Rosalie; Najafi, Aref; Michels, Michelle; Sadayappan, Sakthivel; Carrier, Lucie; Boontje, Nicky M; Kuster, Diederik W D; van Slegtenhorst, Marjon; Dooijes, Dennis; dos Remedios, Cris; ten Cate, Folkert J; Stienen, Ger J M; van der Velden, Jolanda 2012. Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function. Circulation. Heart failure, 5 1, 36-46Verma, Suresh Kumar; Krishnamurthy, Prasanna; Barefield, David; Singh, Neha; Gupta, Rajesh; Lambers, Erin; Thal, Melissa; Mackie, Alexander; Hoxha, Eneda; Ramirez, Veronica; Qin, Gangjian; Sadayappan, Sakthivel; Ghosh, Asish K; Kishore, Raj 2012. Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-?B. Circulation, 126 4, 418-29Weith, Abbey; Sadayappan, Sakthivel; Gulick, James; Previs, Michael J; Vanburen, Peter; Robbins, Jeffrey; Warshaw, David M 2012. Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. Journal of molecular and cellular cardiology, 52 1, 219-27Cuello, Friederike; Bardswell, Sonya C; Haworth, Robert S; Ehler, Elisabeth; Sadayappan, Sakthivel; Kentish, Jonathan C; Avkiran, Metin 2011. Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation. The Journal of biological chemistry, 286 7, 5300-10Palmer, Bradley M; Sadayappan, Sakthivel; Wang, Yuan; Weith, Abbey E; Previs, Michael J; Bekyarova, Tanya; Irving, Thomas C; Robbins, Jeffrey; Maughan, David W 2011. Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical journal, 101 7, 1661-9Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Barefield, David; Cuello, Friederike; Avkiran, Metin; Lasko, Valerie M; Lorenz, John N; Maillet, Marjorie; Martin, Jody L; Brown, Joan Heller; Bers, Donald M; Molkentin, Jeffery D; James, Jeanne; Robbins, Jeffrey 2011. A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circulation research, 109 2, 141-50Bardswell, Sonya C; Cuello, Friederike; Rowland, Alexandra J; Sadayappan, Sakthivel; Robbins, Jeffrey; Gautel, Mathias; Walker, Jeffery W; Kentish, Jonathan C; Avkiran, Metin 2010. Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. The Journal of biological chemistry, 285 8, 5674-82Barefield, David; Sadayappan, Sakthivel 2010. Phosphorylation and function of cardiac myosin binding protein-C in health and disease. Journal of molecular and cellular cardiology, 48 5, 866-75Copeland, O'Neal; Sadayappan, Sakthivel; Messer, Andrew E; Steinen, Ger J M; van der Velden, Jolanda; Marston, Steven B 2010. Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle. Journal of molecular and cellular cardiology, 49 6, 1003-11Senapathy, Periannan; Bhasi, Ashwini; Mattox, Jeffrey; Dhandapany, Perundurai S; Sadayappan, Sakthivel 2010. Targeted genome-wide enrichment of functional regions. PloS one, 5 6, e11138Dhandapany, Perundurai S; Sadayappan, Sakthivel; Xue, Yali; Powell, Gareth T; Rani, Deepa Selvi; Nallari, Prathiba; Rai, Taranjit Singh; Khullar, Madhu; Soares, Pedro; Bahl, Ajay; Tharkan, Jagan Mohan; Vaideeswar, Pradeep; Rathinavel, Andiappan; Narasimhan, Calambur; Ayapati, Dharma Rakshak; Ayub, Qasim; Mehdi, S Qasim; Oppenheimer, Stephen; Richards, Martin B; Price, Alkes L; Patterson, Nick; Reich, David; Singh, Lalji; Tyler-Smith, Chris; Thangaraj, Kumarasamy 2009. 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The Journal of biological chemistry, 282 33, 24057-64Nagayama, Takahiro; Takimoto, Eiki; Sadayappan, Sakthivel; Mudd, James O; Seidman, J G; Robbins, Jeffrey; Kass, David A 2007. Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation, 116 21, 2399-408Yasuda, So-ichiro; Coutu, Pierre; Sadayappan, Sakthivel; Robbins, Jeffrey; Metzger, Joseph M 2007. Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circulation research, 101 4, 377-86Annapoorani, Ponnambalam; Dhandapany, Perundurai S; Sadayappan, Sakthivel; Ramasamy, Subbiah; Rathinavel, Andiappan; Selvam, Govindan Sadasivam 2006. Cardiac isoform of alpha-2 macroglobulin--a new biomarker for myocardial infarcted diabetic patients. Atherosclerosis, 186 1, 173-6Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey 2006. Cardiac myosin binding protein C phosphorylation is cardioprotective. Proceedings of the National Academy of Sciences of the United States of America, 103 45, 16918-23Wang, Hao; Grant, Jennifer E; Doede, Christopher M; Sadayappan, Sakthivel; Robbins, Jeffrey; Walker, Jeffery W 2006. PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. Journal of molecular and cellular cardiology, 41 5, 823-33Sadayappan, Sakthivel; Gulick, James; Osinska, Hanna; Martin, Lisa A; Hahn, Harvey S; Dorn, Gerald W; Klevitsky, Raisa; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey 2005. Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circulation research, 97 11, 1156-63
Becker, Richard C; Owens, A Phillip; Sadayappan, Sakthivel 2020. Tissue-level inflammation and ventricular remodeling in hypertrophic cardiomyopathy. Journal of thrombosis and thrombolysis, 49 2, 177-183Becker, Richard C; Sadayappan, Sakthivel 2020. Designing Human In Vitro Models for Drug Development. Journal of the American College of Cardiology, 75 6, 587-589Butts, Brittany; Ahmed, Mustafa I; Bajaj, Navkaranbir S; Cox Powell, Pamela; Pat, Betty; Litovsky, Silvio; Gupta, Himanshu; Lloyd, Steven G; Denney, Thomas S; Zhang, Xiaoxia; Aban, Inmaculada; Sadayappan, Sakthivel; McNamara, James W; Watson, Michael J; Ferrario, Carlos M; Collawn, James F; Lewis, Clifton; Davies, James E; Dell'Italia, Louis J 2020. Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation. JACC. 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Proceedings of the National Academy of Sciences of the United States of America, 116 43, 21882-21892Manoharan, Palanikumar; Song, Taejeong; Radzyukevich, Tatiana L; Sadayappan, Sakthivel; Lingrel, Jerry B; Heiny, Judith A 2019. KLF2 in Myeloid Lineage Cells Regulates the Innate Immune Response during Skeletal Muscle Injury and Regeneration. iScience, 17 , 334-346McNamara, James W; Singh, Rohit R; Sadayappan, Sakthivel 2019. Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin. Proceedings of the National Academy of Sciences of the United States of America, 116 24, 11731-11736O'Leary, Thomas S; Snyder, Julia; Sadayappan, Sakthivel; Day, Sharlene M; Previs, Michael J 2019. MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy. Journal of molecular and cellular cardiology, 127 , 165-173Sadayappan, Sakthivel 2019. Cardiovascular Leaders Are Made, not Born. 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