Publications

2024

• Daugherty EC, Zhang Y, Xiao Z, Mascia AE, Sertorio M, Woo J, McCann C, Russell KJ, Sharma RA, Khuntia D, Bradley JD, Simone CB 2nd, Breneman JC, Perentesis JP. FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach. Radiat Oncol. 2024 Mar 12;19(1):34. doi: 10.1186/s13014-024-02419-4. PMID: 38475815; PMCID: PMC10935811.

• Chimote AA, Lehn MA, Bhati J, Mascia AE, Sertorio M, Lamba MA, Ionascu D, Tang AL, Langevin SM, Khodoun MV, Wise-Draper TM, Conforti L. Proton Treatment Suppresses Exosome Production in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2024 Feb 29;16(5):1008. doi: 10.3390/cancers16051008. PMID: 38473367; PMCID: PMC10931005.

• Mascia A, McCauley S, Speth J, Nunez SA, Boivin G, Vilalta M, Sharma RA, Perentesis JP, Sertorio M. Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice. Int J Radiat Oncol Biol Phys. 2024 Jan 1;118(1):253-261. doi: 10.1016/j.ijrobp.2023.07.024. Epub 2023 Aug 2. PMID: 37541394.

2023

• Pathak, B.; Lange, T.E.; Lampe, K.; Hollander, E.; Oria, M.; Murphy, K.P.; Salomonis, N.; Sertorio, M.; Oria, M. Development of a Single-Neurosphere Culture to Assess Radiation Toxicity and Pre-Clinical Cancer Combination Therapy Safety.  Cancers 2023, 15, 4916. https://doi.org/10.3390/cancers15204916

• Siddiqui NA, Ventrola AJ, Hartman AR, Konare T, Kamble NS, Thomas SC, Madaan T, Kharofa J, Sertorio MG, Kotagiri N. An Engineered Probiotic Platform for Cancer Epitope-Independent Targeted Radionuclide Therapy of Solid Tumors. Adv Healthc Mater. 2023 Mar 13:e2202870. doi: 10.1002/adhm.202202870. Epub ahead of print. PMID: 36913614.

• Korns J, McCauley S, Lehn M, Takiar V, Sertorio M, Lamba M. Varied Photon Radiation Sources Produce Differences in Cellular Response. Radiat Res. 2023 Apr 1;199(4):422-428. doi: 10.1667/RADE-22-00210.1. PMID: 37039678.

• Mascia A, McCauley S, Speth J, Nunez SA, Boivin G, Vilalta M, Sharma RA, Perentesis JP, Sertorio M. Impact of Multiple Beams on the FLASH Effect in Soft Tissue and Skin in Mice. Int J Radiat Oncol Biol Phys. 2023 Aug 2:S0360-3016(23)07678-2. doi: 10.1016/j.ijrobp.2023.07.024. Epub ahead of print. PMID: 37541394.

2022

• Chihanga, T., S. Vicente-Muñoz, S. Ruiz-Torres, B. Pal, M. Sertorio, P. R. Andreassen, R. Khoury, P. Mehta, S. M. Davies, A. N. Lane, L. E. Romick-Rosendale, and S. I. Wells. "Head and Neck Cancer Susceptibility and Metabolism in Fanconi Anemia." Cancers (Basel) 14, no. 8 (Apr 18 2022). http://dx.doi.org/10.3390/cancers14082040.

• Dubey, P., M. Sertorio, and V. Takiar. "Therapeutic Advancements in Metal and Metal Oxide Nanoparticle-Based Radiosensitization for Head and Neck Cancer Therapy." Cancers (Basel) 14, no. 3 (Jan 20 2022). http://dx.doi.org/10.3390/cancers14030514.
  

• Williams MT, Sugimoto C, Regan SL, Pitzer EM, Fritz AL, Sertorio M, Mascia AE, Vatner RE, Perentesis JP, Vorhees CV. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS One. 2022 Sep 16;17(9):e0274007. doi: 10.1371/journal.pone.0274007. PMID: 36112695; PMCID: PMC9481014

• Mascia AE, Daugherty EC, Zhang Y, Lee E, Xiao Z, Sertorio M, Woo J, Backus LR, McDonald JM, McCann C, Russell K, Levine L, Sharma RA, Khuntia D, Bradley JD, Simone CB 2nd, Perentesis JP, Breneman JC. Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial. JAMA Oncol. 2022 Oct 23:e225843. doi: 10.1001/jamaoncol.2022.5843. Epub ahead of print. PMID: 36273324; PMCID: PMC9589460.

• Daugherty EC, Mascia AE, Zhang Y, Lee E, Xiao Z, Sertorio M, Woo J, McCann C, Russell KJ, Levine LL, Sharma RA, Khuntia D, Bradley J, Simone Nd CB, Perentesis JP, Breneman JC. FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study. JMIR Res Protoc. 2022 Oct 4. doi: 10.2196/41812. Epub ahead of print. PMID: 36206189.

2021

• Cunningham S, McCauley S, Vairamani K, Speth J, Girdhani S, Abel E, Sharma RA, Perentesis JP, Wells SI, Mascia A, Sertorio M. FLASH Proton Pencil Beam Scanning Irradiation Minimizes Radiation-Induced Leg Contracture and Skin Toxicity in Mice. Cancers (Basel). 2021 Mar 1;13(5):1012. doi: 10.3390/cancers13051012. PMID: 33804336; PMCID: PMC7957631.

• Ruiz-Torres, S., M. G. Brusadelli, D. P. Witte, K. A. Wikenheiser-Brokamp, S. Sauter, A. S. Nelson, M.Sertorio, T. M. Chlon, A. Lane, P. A. Mehta, K. C. Myers, M. C. Bedard, B. Pal, D. M. Supp, P. F. Lambert, K. Komurov, M. B. Kovacic, S. M. Davies, and S. I. Wells. "Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin." Cell Stem Cell 28, no. 3 (Mar 4 2021): 424-35.e6. http://dx.doi.org/10.1016/j.stem.2020.10.012,

• Sertorio, M., A. Nowrouzi, M. Akbarpour, K. Chetal, N. Salomonis, S. Brons, A. Mascia, D. Ionascu, S. McCauley, T. Kupneski, A. Köthe, J. Debus, J. P. Perentesis, A. Abdollahi, Y. Zheng, and S. I. Wells. "Differential Transcriptome Response to Proton Versus X-Ray Radiation Reveals Novel Candidate Targets for Combinatorial Pt Therapy in Lymphoma." Radiother Oncol 155 (Feb 2021): 293-303. http://dx.doi.org/10.1016/j.radonc.2020.10.024.

2020

• Williams MT, Sugimoto C, Regan SL, Pitzer EM, Fritz AL, Mascia AE, Sertorio M, Vatner RE, Perentesis JP, Vorhees CV. Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Sci Rep. 2020 Dec 9;10(1):21584. doi: 10.1038/s41598-020-78128-1. PMID: 33299021; PMCID: PMC7726106.

• Ruiz-Torres S, Brusadelli MG, Witte DP, Wikenheiser-Brokamp KA, Sauter S, Nelson AS, Sertorio M, Chlon TM, Lane A, Mehta PA, Myers KC, Bedard MC, Pal B, Supp DM, Lambert PF, Komurov K, Kovacic MB, Davies SM, Wells SI. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell Stem Cell. 2021 Mar 4;28(3):424-435.e6. doi: 10.1016/j.stem.2020.10.012. Epub 2020 Nov 23. PMID: 33232662; PMCID: PMC7935766.

• Sertorio M, Nowrouzi A, Akbarpour M, Chetal K, Salomonis N, Brons S, Mascia A, Ionascu D, McCauley S, Kupneski T, Köthe A, Debus J, Perentesis JP, Abdollahi A, Zheng Y, Wells SI. Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma. Radiother Oncol. 2021 Feb;155:293-303. doi: 10.1016/j.radonc.2020.10.024. Epub 2020 Oct 20. PMID: 33096164.

• Pease NA, Shephard MS, Sertorio M, Waltz SE, Vinnedge LMP. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers (Basel). 2020 Jul 17;12(7):1936. doi: 10.3390/cancers12071936. PMID: 32708944; PMCID: PMC7409092.

• Nowrouzi A, Sertorio MG, Akbarpour M, Knoll M, Krunic D, Kuhar M, Schwager C, Brons S, Debus J, Wells SI, Wells JM, Abdollahi A. Personalized Assessment of Normal Tissue Radiosensitivity via Transcriptome Response to Photon, Proton and Carbon Irradiation in Patient-Derived Human Intestinal Organoids. Cancers (Basel). 2020 Feb 18;12(2):469. doi: 10.3390/cancers12020469. PMID: 32085439; PMCID: PMC7072449.