Publications

2025

Webster, Rose P; Kirley, Terence L; Ray, Andrew R; Chan, Zhen-Hin; Norman, Andrew B 2025. Synthesis and characterization of a functional benzoylecgonine - bovine serum albumin conjugate for quantification of a humanized monoclonal anti-cocaine antibody. Biochemistry and biophysics reports, 44 , 102282

Kirley, Terence L; Norman, Andrew B 2025. Selective real-time disulfide reduction with simultaneous fluorescent labeling of a humanized anti-cocaine mAb. Biochemistry and biophysics reports, 44 , 102243

Song, Heather J; Desai, Jhanvi N; Norman, Mantana K; Norman, Andrew B 2025. Using cocaine and apomorphine self-administration in rats to measure the pharmacokinetics of competitive dopamine receptor antagonists administered by different routes. Scientific reports, 15 1, 24087

Kirley, Terence L; Norman, Andrew B 2025. Decreased solubility and increased adsorptivity of a biotinylated humanized anti-cocaine mAb. Analytical biochemistry, 696 , 115690

2024

Kirley, Terence L; Norman, Andrew B 2024. Novel partial reduction of the humanized anti-cocaine mAb h2E2 for selective cysteine labeling. Biochemical and biophysical research communications, 692 , 149362

2023

Webster, Rose P; Marckel, Jordan A; Norman, Andrew B 2023. Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity. Human vaccines & immunotherapeutics, 19 3, 2274222

Desai, Jhanvi N; Tron Esqueda, Luis E; Norman, Andrew B 2023. The ascending limb of the cocaine unit dose-response function in rats as an experimental artifact. Scientific reports, 13 1, 16614

Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Scientific reports, 13 1, 14566

Kirley, Terence L; Norman, Andrew B 2023. Characterization and optimization of fluorescein isothiocyanate labeling of humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 35 , 101520

Zinani, Dakota B; Desai, Jhanvi N; Norman, Andrew B 2023. The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose. Heliyon, 9 7, e17988

Kirley, Terence L; Norman, Andrew B 2023. Reformulation and Thermal Stability of a Therapeutic Anti-Cocaine mAb. Journal of pharmaceutical sciences, 112 6, 1595-1602

Koch, Sheryl E; Marckel, Jordan A; Rubinstein, Jack; Norman, Andrew B 2023. A humanized anti-cocaine mAb antagonizes the cardiovascular effects of cocaine in rats. Pharmacology research & perspectives, 11 1, e01045

Desai, Jhanvi N; Muccilli, Abigail R; Tron Esqueda, Luis E; Welge, Jeffrey A; Norman, Andrew B 2023. Differential Effect of Fixed Ratio Magnitude on the Rate of Lever-Pressing and Interinjection Intervals of Cocaine Self-Administration in Rats. Current therapeutic research, clinical and experimental, 99 , 100727

2022

Kirley, Terence L; Norman, Andrew B 2022. Isothermal titration calorimetry determination of thermodynamics of binding of cocaine and its metabolites to humanized h2E2 anti-cocaine mAb. Biochemistry and biophysics reports, 32 , 101354

Tsibulsky, Vladimir L; Norman, Andrew B 2022. The progressive ratio and fixed ratio 1 schedules of cocaine self-administration in rats convey the same information. Scientific reports, 12 1, 19683

Turner, Mackenzie E; Wetzel, Hanna N; Zinani, Dakota B; Crutchfield, Christopher A; Norman, Andrew B 2022. Effects of a recombinant humanized anti-cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice. Pharmacology research & perspectives, 10 5, e01009

Kirley, Terence L; Norman, Andrew B 2022. Critical evaluation of fluorescent dyes to evaluate the stability and ligand binding properties of an anti-cocaine mAb, h2E2. Journal of immunological methods, 508 , 113323

Kirley, Terence L; Greis, Kenneth D; Norman, Andrew B 2022. Tyrosine nitration of a humanized anti-cocaine mAb differentially affects ligand binding of cocaine and its metabolites. Biochemistry and biophysics reports, 30 , 101278

Wetzel, Hanna N; Tsibulsky, Vladimir L; Norman, Andrew B 2022. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats. Scientific reports, 12 1, 8782

Kirley, Terence L; Norman, Andrew B; Greis, Kenneth D 2022. Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb. The Journal of biological chemistry, 298 3, 101689

Zinani, Dakota B; Wetzel, Hanna N; Norman, Andrew B 2022. The compulsion zone explains the self-administration of cocaine, RTI-55 and bupropion in rats. Brain research, 1774 , 147707