Publications

Complete list of our publications, please visit: Guo Chang Fan Publications (Pubmed)
Citations of our published work:  Guo Chang Fan Citations (Google Scholar)

2024

• Ni R, Ji XY, Cao T, Liu XW, Wang C, Lu C, Peng A, Zhang ZX, Fan GC, Zhang J, Su ZL, Peng TQ. Nicotinamide Mononucleotide Protects Septic Hearts in Mice via Preventing Cyclophilin F Modification and Lysosomal Dysfunction. Acta Pharmacol Sin. 2024 Dec 2. doi: 10.1038/s41401-024-01424-3. Epub ahead of print. PMID: 39623043.
• Zhu R, Zhang Y, Wang X, Liu BD, Chowdhury D, Li Z, Pan M, Peng T, Chen J, Huang W, Zhan L, Fan GC. Probiotic Bacteria-Released Extracellular Vesicles Enhance Macrophage Phagocytosis in Polymicrobial Sepsis by Activating the FPR1/2 Pathway. Mol Med. 2024 Nov 14;30(1):216. doi: 10.1186/s10020-024-00959-9. PMID: 39543493; PMCID: PMC11566284.
• Ni R, Cao T, Ji X, Peng A, Zhang Z, Fan GC, Stathopulos P, Chakrabarti S, Su Z, Peng T. DNA Damage-Inducible Transcript 3 Positively Regulates RIPK1-Mediated Necroptosis. Cell Death Differ. 2024 Oct 3. doi: 10.1038/s41418-024-01385-4. Epub ahead of print. PMID: 39362992.
• Wang X, Du W, Li Y, Yang HH, Zhang Y, Akbar R, Morgan H, Peng T, Chen J, Sadayappan S, Hu YC, Fan Y, Huang W, Fan GC. Macrophage-Enriched Sectm1a Promotes Efficient Efferocytosis to Attenuate Ischemia/Reperfusion-Induced Cardiac Injury. JCI Insight. 2024 Mar 8;9(5): e173832. doi: 10.1172/jci.insight.173832. PMID: 38456501; PMCID: PMC10972593.
  

2023

• Cao T, Ni R, Ding W, Ji X, Fan GC, Zhang Z, Peng T. Nicotinamide Mononucleotide as a Therapeutic Agent to Alleviate Multi-Organ Failure in Sepsis. J Transl Med. 2023 Dec 6;21(1):883. doi: 10.1186/s12967-023-04767-3. PMID: 38057866; PMCID: PMC10699070.
• Liu BD, Akbar R, Oliverio A, Thapa K, Wang X, Fan GC. Bacterial Extracellular Vesicles in the Regulation of Inflammatory Response and Host-Microbe Interactions. Shock. 2024 Feb 1;61(2):175-188. doi: 10.1097/SHK.0000000000002252. Epub 2023 Oct 12. PMID: 37878470; PMCID: PMC10921997.
• Feng Y, Cai L, Pook M, Liu F, Chang CH, Mouti MA, Nibhani R, Militi S, Dunford J, Philpott M, Fan Y, Fan GC, Liu Q, Qi J, Wang C, Hong W, Morgan H, Wang M, Sadayappan S, Jegga AG, Oppermann U, Wang Y, Huang W, Jiang L, Pauklin S. BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2024 Jan;166(1):139-154. doi: 10.1053/j.gastro.2023.09.021. Epub 2023 Sep 21. PMID: 37739089; PMCID: PMC11304550.
• Yang HH, Wang X, Li S, Liu Y, Akbar R, Fan GC. Lipocalin Family Proteins and Their Diverse Roles in Cardiovascular Disease. Pharmacol Ther. 2023 Apr;244:108385. doi: 10.1016/j.pharmthera.2023.108385. Epub 2023 Mar 24. PMID: 36966973; PMCID: PMC10079643
• Saas P, Fan GC. Hypoxia and Inflammation: A Two-Way Street. Front Immunol. 2023 Mar 8; 14:1171116. doi: 3389/fimmu.2023.1171116. PMID: 36969222; PMCID: PMC10031103.

2022

• Li H, Cao T, Ding W, Liang L, Fan GC, Qu L, Peng T. Pharmacological Inhibition of Rac1 Attenuates Myocardial Abnormalities in Tail-Suspended Mice. J Cardiovasc Transl Res. 2022 Aug;15(4):805-815. doi: 10.1007/s12265-021-10197-7.
• Ren L, Du W, Song D, Lu H, Hamblin MH, Wang C, Du C, Fan GC, Becker RC, Fan Y. Genetic Ablation of Diabetes-Associated Gene Ccdc92 Reduces Obesity and Insulin Resistance in Mice. iScience. 2022 Dec 8;26(1):105769. doi: 10.1016/j.isci.2022.105769. PMID: 36594018; PMCID: PMC9804112.
• Cao T, Ni R, Ding W, Ji X, Li L, Liao G, Lu Y, Fan GC, Zhang Z, Peng T. MLKL-Mediated Necroptosis is a Target for Cardiac Protection in Mouse Models of Type-1 Diabetes. Cardiovasc Diabetol. 2022 Aug 27;21(1):165. doi: 10.1186/s12933-022-01602-9. PMID: 36030201; PMCID: PMC9420252.
• Ji XY, Zheng D, Ni R, Wang JX, Shao JQ, Vue Z, Hinton A Jr, Song LS, Fan GC, Chakrabarti S, Su ZL, Peng TQ. Sustained Over-Expression of Calpain-2 Induces Age-Dependent Dilated Cardiomyopathy in Mice Through Aberrant Autophagy. Acta Pharmacol Sin. 2022 Nov;43(11):2873-2884. doi: 10.1038/s41401-022-00965-9. Epub 2022 Aug 19. PMID: 35986214; PMCID: PMC9622835.
• Li Q, Li Y, Huang W, Wang X, Liu Z, Chen J, Fan Y, Peng T, Sadayappan S, Wang Y, Fan GC. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Front Immunol. 2022 Jun 10; 13:930397. doi: 10.3389/fimmu.2022.930397. PMID: 35757735; PMCID: PMC9226549.
• Feng Y, Cai L, Hong W, Zhang C, Tan N, Wang M, Wang C, Liu F, Wang X, Ma J, Gao C, Kumar M, Mo Y, Geng Q, Luo C, Lin Y, Chen H, Wang SY, Watson MJ, Jegga AG, Pedersen RA, Fu JD, Wang ZV, Fan GC, Sadayappan S, Wang Y, Pauklin S, Huang F, Huang W, Jiang L. Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation. 2022 May 31;145(22):1663-1683. doi: 10.1161/CIRCULATIONAHA.121.055781.
• Zhang M, Zhong H, Cao T, Huang Y, Ji X, Fan GC, Peng T. Gamma-Aminobutyrate Transaminase Protects against Lipid Overload-Triggered Cardiac Injury in Mice. Int J Mol Sci. 2022 Feb 16;23(4):2182. doi: 10.3390/ijms23042182. PMID: 35216295; PMCID: PMC8874535.
• Jiang L, Liang J, Huang W, Ma J, Park KH, Wu Z, Chen P, Zhu H, Ma JJ, Cai W, Paul C, Niu L, Fan GC, Wang HS, Kanisicak O, Xu M, Wang Y. CRISPR Activation of Endogenous Genes Reprograms Fibroblasts into Cardiovascular Progenitor Cells for Myocardial Infarction Therapy. Mol Ther. 2022 Jan 5;30(1):54-74. doi: 10.1016/j.ymthe.2021.10.015. PMID: 34678511; PMCID: PMC8753567.

2021

• Wang P, Mu X, Zhao H, Li Y, Wang L, Wolfe V, Cui SN, Wang X, Peng T, Zingarelli B, Wang C, Fan GC. Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXRα-Mediated Macrophage Phagocytosis. Front Immunol. 2021 Feb 17; 12:647070. doi: 10.3389/fimmu.2021.647070. PMID: 33679812; PMCID: PMC7925632
• Cui SN, Tan HY, Fan GC. Immunopathological Roles of Neutrophils in Virus Infection and COVID-19. Shock. 2021 Sep 1;56(3):345-351. doi: 10.1097/SHK.0000000000001740. PMID: 33534399; PMCID: PMC8354486.
• Mu X, Fan H, Wang P, Li Y, Domenico K, Li Q, Wang X, Essandoh K, Chen J, Peng T, Fan GC. Sectm1a Facilitates Protection Against Inflammation-Induced Organ Damage Through Promoting TRM Self-Renewal. Mol Ther. 2021 Mar 3;29(3):1294-1311. doi: 10.1016/j.ymthe.2020.12.001. Epub 2020 Dec 3. PMID: 33279722; PMCID: PMC7934637.
• Liang L, Li H, Cao T, Qu L, Zhang L, Fan GC, Greer PA, Li J, Jones DL, Peng T. Calpain Activation Mediates Microgravity-Induced Myocardial Abnormalities in Mice via p38 and ERK1/2 MAPK Pathways. J Biol Chem. 2020 Dec 4;295(49):16840-16851. doi: 10.1074/jbc.RA119.011890. Epub 2020 Sep 28. PMID: 32989050; PMCID: PMC7864076.
• Zheng D, Cao T, Zhang LL, Fan GC, Qiu J, Peng TQ. Targeted Inhibition of Calpain in Mitochondria Alleviates Oxidative Stress-Induced Myocardial Injury. Acta Pharmacol Sin. 2021 Jun;42(6):909-920. doi: 10.1038/s41401-020-00526-y. Epub 2020 Sep 23. PMID: 32968209; PMCID: PMC8149722.
• Li Y, Li Q, Fan GC. Macrophage Efferocytosis in Cardiac Pathophysiology and Repair. Shock. 2021 Feb 1;55(2):177-188. doi: 10.1097/SHK.0000000000001625. PMID: 32694395; PMCID: PMC8875399.
• Mu X, Li Y, Fan GC. Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation. Shock. 2021 Jan 1;55(1):14-23. doi: 10.1097/SHK.0000000000001601. PMID: 32590701; PMCID: PMC8859816.
• Li Y, Deng S, Wang X, Huang W, Chen J, Robbins N, Mu X, Essandoh K, Peng T, Jegga AG, Rubinstein J, Adams DE, Wang Y, Peng J, Fan GC. Sectm1a Deficiency Aggravates Inflammation-Triggered Cardiac Dysfunction Through Disruption of LXRα Signaling in Macrophages. Cardiovasc Res. 2021 Feb 22;117(3):890-902. doi: 10.1093/cvr/cvaa067. PMID: 32170929; PMCID: PMC8453795

2020

• Essandoh K, Deng S, Wang X, Li Y, Li Q, Mu X, Peng T, Fan GC. Tsg101 Is Involved in the Sorting and Re-Distribution of Glucose Transporter-4 to the Sarcolemma Membrane of Cardiac Myocytes. Cells. 2020 Aug 21;9(9):1936. doi: 10.3390/cells9091936. PMID: 32839388; PMCID: PMC7565110.
• Mu X, Wang P, Wang X, Li Y, Zhao H, Li Q, Essandoh K, Deng S, Peng T, Fan GC. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR. J Immunol. 2020 Sep 15;205(6):1633-1643. doi: 10.4049/jimmunol.2000440. Epub 2020 Aug 7. PMID: 32769121; PMCID: PMC7484034.
• Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan JL, Wang Y, Jegga A, Huang K, Fan GC. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox Biol. 2020 May; 32:101453. doi: 10.1016/j.redox.2020.101453. Epub 2020 Feb 6. PMID: 32057709; PMCID: PMC7264471.
• Wang L, Li Y, Wang X, Wang P, Essandoh K, Cui S, Huang W, Mu X, Liu Z, Wang Y, Peng T, Fan GC. GDF3 Protects Mice Against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. Cells. 2020 Jan 3;9(1):120. doi: 10.3390/cells9010120. PMID: 31947892; PMCID: PMC7017037.