Departments / Internal Medicine / Divisions / Cardiovascular Health and Disease / Research Activity / Kevin Haworth / Publications

Publications

For the most up-to-date list, please find our publications via ORCID, PubMed, or Google Scholar.

Last updated 1 April 2022

Peer-Reviewed Publications

  1. Mirna Lechpammer, Rohan Rao, Sanjit Shah, Mona Mirheydari, Debanjan Bhattacharya, Abigail Koehler, Donatien K. Toukam, Kevin J. Haworth, Daniel A. Pomeranz Krummel, Soma Sengupta. (2022) Advances in Immunotherapy for the Treatment of Adult Glioblastoma: overcoming chemical and physical barriers. Cancers. 14(7):1627 1-22 doi: 10.3390/cancers1407162

  2. Adam D. Maxwell, Kevin J. Haworth, Christy K. Holland, Samuel A. Hendley, Wayne Keider, Kenneth, B. Bader. (2022). Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 69(1):156-165 doi: 10.1109/TUFFC.2021.3113635

  3. Demetria M. Fischesser, Bin Bo, Rachel P. Benton, Haili Su, Newsha Jahanpanah, Kevin J. Haworth. (2021) Controlling Reperfusion Injury with Controlled Reperfusion: Historical Perspectives and New Paradigms. Journal of Cardiovascular Pharmacology and Therapeutics. 26(6):504-523 doi: 10.1177/10742484211046674

  4. Samuel A. Hendley, Jonathan D. Paul, Adam D. Maxwell, Kevin J. Haworth, Christy K. Holland, Kenneth, B. Bader. (2021). Clot degradation under the action of histotripsy bubble activity and a lytic drug. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 68(9):2942-2952 doi: 10.1109/TUFFC.2021.3052393

  5. Maxime Lafond, Nuria G. Salido, Kevin J. Haworth, Alexander S. Hannah, Curtis Genstler, Christy K. Holland. (2021). Cavitation emissions Nucleated by Definity(R) Infused Through an EkoSonic(R) Catheter in a Flow Phantom. Ultrasound in Medicine and Biology. 47(3):693-709 doi: 10.1016/j.ultrasmedbio.2020.10.010

  6. Patrick H. Kee, Melanie R. Moody, Shao-Ling Huang, Hyunggun Kim, Xing Yin, Tao Peng, Susan T. Laing, Melvin E. Klegerman, Mohammad H. Rahbar, Deborah Vela, Curtis Genstler, Kevin J. Haworth, Christy K. Holland, David D. McPherson. (accepted) “Stabilizing peri- stent restenosis using a novel therapeutic carrier.” JACC: Basic to Translational Science.

  7. Viktor Bollen, Samuel A. Hendley, Jonathan D. Paul, Adam D. Maxwell, Kevin J. Haworth, Christy K. Holland, Kenneth B. Bader. (2020) “In vitro thrombolytic efficacy of single- and five-cycle histotripsy pulses and rt-PA.” Ultrasound in Medicine and Biology. 46(2):336-349 doi: 10.1016/j.ultrasmedbio.2019.10.009

  8. Robert Kleven, Himanshu Shekhar, Kunal Karani, Nuria Salido, T. Douglas Mast, Kevin J. Haworth, Christy K. Holland. (2019) “The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro.” Physics in Medicine and Biology. 64(16):165015(1-17) doi: 10.1088/1361-6560/ab293b

  9. Karla P. Mercado-Shekhar, Haili Su, Deepak S. Kalaikadal, John N. Lorenz, Raj M. Manglik, Christy K. Holland, Andrew N. Redington, Kevin J. Haworth. (2019) “Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.” Ultrasonics Sonochemistry. 56:114-124 doi: 10.1016/j.ultsonch.2019.03.029

  10. Himanshu Shekhar, Pala Arunkumar, Tao Peng, Melanie R. Moody, Kevin J. Haworth, Shaoling Huang, David D. McPherson, Christy K. Holland. (2019) “Lipid-shelled microbubbles for ultrasound-triggered release of xenon.” Neurotherapeutics. doi: 10.1007/s13311-019-00733-4

  11. Khoi Nguyen, Hsuan-Yeh Pan, Kevin J. Haworth, Eric Mahoney, Karla P. Mercado-Shekhar, Chia-Ying Lin, Zhe Zhang, Yoonjee Park. (2019) “Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment.” Ultrasound in Medicine and Biology. 45(1):160-169 doi: 10.1016/j.ultrasmedbio.2018.09.014

  12. Karla P. Mercado-Shekhar, Robert Kleven, Hermes Aponte Rivera, Ryden Lewis, Kunal B. Karani, Hendrick J. Vos, Todd A. Abruzzo, Kevin J. Haworth, Christy K. Holland. (2018) “The Effect of Clot Stiffness on rt-PA Lytic Susceptibility In Vitro.” Ultrasound in Medicine and Biology. 44(12):2710-2727 doi: 10.1016/j.ultrasmedbio.2018.08.005 

  13. Kenneth B. Bader, Kevin J. Haworth, Adam D. Maxwell, and Christy K. Holland. (2018). Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-induced Liq- uefaction In Vitro. IEEE Medical Imaging. 37(1):106-115 doi: 10.1109/TMI.2017.2735238

  14. Kevin J. Haworth, Kenneth B. Bader, Kyle T. Rich, Christy K. Holland, T. Douglas Mast. (2017). Quantitative Frequency-Domain Passive Cavitation Imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64(1):177-191 doi: 10.1109/TUFFC.2016.2620492

  15. Mark J. Schulz, Guangfeng Hou, Vianessa Ng, Massoud Rabiee, Marc Cahay, Sumeet Chaud- hary, Dustin Lindley, Devika Chauhan, Michael Paine, Dineshwaran Vijayakumar, Chenhao Xu, Zhangzhang Yin, Kevin J. Haworth, Yijun Liu, Murali Sundaram, Weifeng Li, David Mast, Vesselin N. Shanov. (2017). Science to commercialization of carbon nanotube sheet and yarn. WSEAS Transactions on Applied and Theoretical Mechanics. 12:41-50.

  16. Jonathan T. Sutton, Kevin J. Haworth, Shiva Kumar Shanmukhappa, Melanie R. Moody, Melvin R. Klegerman, Joseph K. Griffin, Daniella M. Patton, David D. McPherson, Christy K. Holland. (2016). Delivery of bevacizumab to atheromatous porcine carotid tissue using echogenic liposomes. Drug Delivery. 23(9):3594-3605 doi: 10.1080/10717544.2016.1212441

  17. Kenneth B. Bader, Kevin J. Haworth, Himanshu Shekhar, Adam Maxwell, Tao Peng, David D. McPherson, Christy K. Holland. (2016). Efficacy of histotripsy combined with rt-PA in vitro. Physics in Medicine and Biology. 61(14):5253-5274 doi: 10.1088/0031-9155/61/14/5253

  18. Karla P. Mercado, Kirthi Radhakrishnan, Kyle Stewart, Lindsay Snider, Devin Ryan, Kevin J. Haworth. (2016). Empirical model for size isolating ultrasound-triggered phase-shift emulsions using differential centrifugation. Journal of the Acoustical Society of America - Express Letters. 135(5):EL142-148 doi: 10.1121/1.4946831

  19. Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth. (2016). Scavenging dissolved oxygen via acoustic droplet vaporization. Ultrasonics Sonochemistry. 31:394-403 doi: 10.1016/j.ultsonch.2016.01.019

  20. Kevin J. Haworth, Jason L. Raymond, Kirthi Radhakrishnan, Melanie R. Moody, Shaoling Huang, Tao Peng, Himanshu Shekhar, Melvin E. Klegerman, Hyunggun Kim, David D. McPherson, and Christy K. Holland. (2016). Trans-stent B-mode ultrasound and passive cav- itation imaging. Ultrasound in Medicine and Biology. 42(2):518-527 doi: 10.1016/j.ultrasmedbio.2015.08.014

  21. Melvin E. Klegerman, Ali K. Naji, Kevin J. Haworth, Yuejiao Zou, Eva Golunski, Tao Peng, George L. Britton, Shao-Ling Huang, Christy K. Holland, David D. McPherson. (2016). Ultrasound-enhanced bevacizumab release from echogenic liposomes for inhibition of atheroma progression. Journal of Liposome Research. 26(1):47-56 doi: 10.3109/08982104.2015.1029494

  22. Kevin J. Haworth, Vasant A. Salgaonkar, Nicholas M. Corregan, Christy K. Holland, T. Douglas Mast. (2015). Using passive cavitation images to classify high-intensity focused ultrasound lesions. Ultrasound in Medicine and Biology. 41(9):2420-2434 doi: 10.1016/j.ultrasmedbio.2015.04.025

  23. Kevin J. Haworth, Christopher R. Weidner, Todd A. Abruzzo, Jason T. Shearn, Christy K. Holland. (2015). Mechanical properties and fibrin characteristics of endovascular coil- clot complexes: Relevance to endovascular cerebral aneurysm repair paradigms. Journal of NeuroInterventional Surgery. 7(4):291-296 doi: 10.1136/neurintsurg-2013-011076

  24. Kirthi Radhakrishnan, Kevin J. Haworth, Shao-Ling Huang, David D. McPherson, Christy K. Holland. (2015). Loss of echogenicity and onset of cavitation from echogenic liposomes: Pulse repetition frequency independence. Ultrasound in Medicine and Biology. 41(1):208-221 doi: 10.1016/j.ultrasmedbio.2014.08.021

  25. Jason L. Raymond, Kevin J. Haworth, Kenneth B. Bader, Kirthi Radhakrishnan, Joseph K. Griffin, Shao-Ling Huang, David D. McPherson, Christy K. Holland. (2014). Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents. Ultrasound in Medicine and Biology. 40(2):410-421 doi: 10.1016/j.ultrasmedbio.2013.09.018

  26. Kirthi Radhakrishnan, Kenneth B. Bader, Kevin J. Haworth, Jonathan A. Kopechek, Jason L. Raymond, Bin Huang, Shao-Ling Huang, David D. McPherson, Christy K. Holland. (2013). Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.Physics in Medicine and Biology. 58(18):6541-6563 doi: 10.1088/0031-9155/58/18/6541

  27. Sheryl E. Koch, Kevin J. Haworth, Nathan Robbins, Margaret A. Smith, Navneet Lather, Ahmad Anjak, Min Jiang, Priyanka Varma, W. Keith Jones, and Jack Rubinstein. (2013). Age and gender related changes in myocardial function in wild type FVB/N mice as evaluated by conventional and vector velocity echocardiography imaging. Ultrasound in Medicine and Biology. 39(11):2034-2043 doi: 10.1016/j.ultrasmedbio.2013.04.002

  28. Jonathan T. Sutton, Kevin J. Haworth, Gail J. Pyne-Geithman, Christy K. Holland. (2013). Ultrasound-mediated drug delivery for cardiovascular disease. Expert Opinions on Drug De- livery. 10(5):573-592 doi: 10.1517/17425247.2013.772578

  29. Jonathan A. Kopechek, Kevin J. Haworth, Kirthi Radhakrishnan, Shao-Ling Huang, Melvin E. Klegerman, David D. McPherson, Christy K. Holland. (2013). The impact of microbub- bles on measurement of drug release from echogenic liposomes. UItrasonics Sonochemistry. 20(4):1121-1130 doi: 10.1016/j.ultsonch.2012.12.005

  30. Robert Littleton, Kevin J. Haworth, Hong Tang, Kenneth Setchell, Sandra Nelson, Jay Hove. (2013). Automated in vivo platform for the discovery of functional food treatments of hypercholesterolemia in zebrafish. PLoS ONE. 8(1):e52409 1-9 doi: 10.1371/journal.pone.0052409

  31. Kirthi Radhakrishnan, Kevin J. Haworth, Shao-Ling Huang, Melvin E. Klegerman, David D. McPherson, Christy K. Holland. (2012). Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom. Ultrasound in Medicine and Biology. 38(11):1970-1981 doi: 10.1016/j.ultrasmedbio.2012.06.012

  32. Kevin J. Haworth, T. Douglas Mast, Kirthi Radhakrishnan, Mark T. Burgess, Jonathan A. Kopechek, Shao-Ling Huang, David D. McPherson, Christy K. Holland. (2012). Passive imaging with pulsed ultrasound insonations. Journal of the Acoustical Society of America. 132(1):544-553 doi: 10.1121/1.4728230

  33. Jonathan A. Kopechek, Kevin J. Haworth, Jason L. Raymond, T. Douglas Mast, Stephen R. Perrin Jr., Melvin E. Klegerman, Shao-Ling Huang, Tyrone M. Porter, David D. McPherson, Christy K. Holland. (2011). Acoustic characterization of echogenic liposomes: frequency- dependent attenuation and backscatter. Journal of the Acoustical Society of America. 130(5, Pt. 2):3472-3481 doi: 10.1121/1.3626124

  34. Man Zhang, Mario L. Fabiilli, Kevin J. Haworth, Frederic R. Padilla, Scott D. Swanson, Oliver D. Kripfgans, Paul L. Carson, J. Brian Fowlkes. (2011). Acoustic droplet vaporization for enhancement of thermal ablation by high intensity focused ultrasound. Academic Radiology. 18(9):1123-1132 doi: 10.1016/j.acra.2011.04.012

  35. Kathryn E. Hitchcock, Nikolas M. Ivancevich, Kevin J. Haworth, Danielle N. Caudell, Deborah C. Vela, Jonathan T. Sutton, Gail J. Pyne-Geithman, Christy K. Holland. (2011). Ultrasound-enhanced rt-PA thrombolysis in an ex vivo porcine carotid artery model. Ultra- sound in Medicine and Biology. 37(8):1240-1251, doi: 10.1016/j.ultrasmedbio.2011.05.011

  36. Man Zhang, Mario L. Fabiilli, Kevin J. Haworth, J. Brian Fowlkes, Oliver D. Kripfgans, William W. Roberts, Kimberly A. Ives, Paul L. Carson. (2010). Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound in Medicine and Biology. 36(10):1691-1703, doi: 10.1016/j.ultrasmedbio.2010.06.020

  37. Mario L. Fabiilli, Kevin J. Haworth, Ian E. Sebastian, Oliver D. Kripfgans, Paul L. Carson, J. Brian Fowlkes. (2010). Delivery of chlorambucil using acoustically-triggered, perfluoropen- tane emulsions. Ultrasound in Medicine and Biology. 36(8):1364-1375, doi: 10.1016/j.ultrasmedbio.2010.04.019

  38. Kevin J. Haworth, J. Brian Fowlkes, Paul L. Carson, Oliver D. Kripfgans. (2009). Gen- eralized shot noise model for time-reversal in multiple-scattering media allowing for arbitrary inputs and windowing. Journal of the Acoustical Society of America. 125(5):3129-3140, doi: 10.1121/1.3106133

  39. Mario L. Fabiilli, Kevin J. Haworth, Oliver D. Kripfgans, Paul L. Carson, J. Brian Fowlkes. (2009). The role of inertial cavitation in acoustic droplet vaporization. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 56(5):1006-1017, doi: 10.1109/TUFFC.2009.1132

  40. Kevin J. Haworth, J. Brian Fowlkes, Paul L. Carson, Oliver D. Kripfgans. (2008). Towards aberration correction of transcranial ultrasound using acoustic droplet vaporization.Ultrasound in Medicine and Biology. 34(3):435-445, doi: 10.1016/j.ultrasmedbio.2007.08.004

Proceedings Articles

  1. Newsha Jahanpanah, Sneha Sharma, Karla P. Mercado-Shekhar, Haili Su, Hunter A. Palcich, Austin M. Wanek, Kevin J. Haworth. (2019). Hemolysis Resulting from Acoustic Droplet Vaporization and Inertial Cavitation. Proceedings of Meetings on Acoustics. 36(1):020001 doi: 10.1121/2.0001240

  2. Kevin J. Haworth, Bryan H. Goldstein, Karla P. Mercado-Shekhar, Rohan Srivastava, P. Arunkumar, Haili Su, Ellena M. Privitera, Christy K. Holland, Andrew N. Redington. (2017). Dissolved Oxygen Scavenging by Acoustic Droplet Vaporization using Intravascular Ultrasound. 2017 IEEE International Ultrasonics Symposium Proceedings. 1:1-4 doi: 10.1109/ULT-SYM.2017.8091704

  3. Kevin J. Haworth, Vasant A. Salgaonkar, Nicholas M. Corregan, Christy K. Holland, T. Douglas Mast. (2013). Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focused ultrasound thermal ablation in ex vivo bovine liver. Proceedings of Meetings on Acoustics. 19:075022 doi: 10.1121/1.4800327

  4. Kevin J. Haworth, Oliver D. Kripfgans. (2008). Initial Growth of Ultrasonically Vaporized Perfluorocarbon Microdroplets. 2008 IEEE International Ultrasonics Symposium Proceedings. 1:623-626

  5. Kevin J. Haworth, Mario L. Fabiilli, J. Brian Fowlkes, Man Zhang, Oliver D. Kripfgans, William W. Roberts, Paul L. Carson. (2008). Mean Echo Power as a Measure of Flow Reduction for Bubble Occlusion Therapy. 2008 IEEE International Ultrasonics Symposium Proceedings. 1:768-771

  6. Mario L. Fabiilli, Kevin J. Haworth, Oliver D. Kripfgans, Paul L. Carson, J. Brian Fowlkes. (2008). The Role of Inertial Cavitation in Acoustic Droplet Vaporization. 2008 IEEE Inter- national Ultrasonics Symposium Proceedings. 1:776-779

 

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