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Department of

Surgery

Photo of  Steven Boyce, PhD

Steven Boyce, PhD

Professor of Surgery; Director, Engineered Skin Laboratories, Shriners Hospitals for Children - Cincinnati

Education/Credentials
  • Doctoral Degree: University of Colorado
  • Bachelor's Degree: University of Colorado
  • Postdoctoral Training: University of California - San Diego

Contact Information

Peer Reviewed Publications

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Boyce, S.T.; Bailey, J.K.; Warner, P.; Yakuboff, K.P.; Simpson, P.S.; Rieman, M.T.; and Kagan, R.J. 2015. Reduced mortality and donor site harvesting after treatment of deep, extensive burns with autologous engineered skin substitutes. Submitted , ,

Boyce, S.T.; Lloyd, C.M.; and Supp, D.M. 2015. Tyrosinase inhibitors for regulation of cellular viability and melanin synthesis in cultured human melanocytes for clinical transplantation J Invest Dermatol, ,

Boyce, S.T.; Lloyd, C.M.; and Supp, D.M. 2015. Induction of VEGF expression in engineered skin substitutes by hypobaric oxygen Tissue Engineering, ,

Boyce, S.T.; Supp, A.P.; Reed, M.A.; Kagan, R.J. 2015. Quantitative assessment of skin pliability after treatment of full thickness burns with cultured skin substitutes and split-thickness autografts combined with Integra Artifical Skin or cadaveric allograft J Burn Care Res, ,

Boyce, S.T.; Zimmerman, R.L.; Lloyd, C.M.; Supp, D.M. 2015. Restoration of skin color by human melanocytes in engineered skin substitutes grafted to full-thickness wounds. J Invest Dermatol, ,

Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, ,

Lloyd, C.M.; Besse, J.A.; and Boyce, S.T. 2014. Controlled rate freezing to regulate the structure of collagen-glycosaminoglycan scaffolds in engineered skin substitutes. J Biomed Mater Res- Part B, ,

Rieman, Mary T; Neely, Alice N; Boyce, Steven T; Kossenjans, William J; Durkee, Paula J; Zembrodt, Jacquelyn M; Puthoff, Barbara K; Kagan, Richard J 2014. Amish burn ointment and burdock leaf dressings: assessments of antimicrobial and cytotoxic activities. Journal of burn care & research : official publication of the American Burn Association, 35 4, e217-23

Sander, Edward A; Lynch, Kaari A; Boyce, Steven T 2014. Development of the mechanical properties of engineered skin substitutes after grafting to full-thickness wounds. Journal of biomechanical engineering, 136 5, 051008

Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M 2013. Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370

Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664

Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M 2012. Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51

Chavez-Munoz, Claudia; Hartwell, Ryan; Jalili, Reza B; Carr, Matthew; Kilani, Ruhangiz T; Jafarnejad, Seyed Mehdi; Rahmani-Neishabour, Elham; Forouzandeh, Farshad; Boyce, Steven T; Ghahary, Aziz 2012. Application of an indoleamine 2,3-dioxygenase-expressing skin substitute improves scar formation in a fibrotic animal model. The Journal of investigative dermatology, 132 5, 1501-5

Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5

Supp, D.M.; Glaser, K.; Hahn, J.M.; McFarland, K.L.; Boyce, S.T. 2012. Abnormal responses of keloid tissue to wounding identified using an in vitro model system Eplasty, 12 , 184-187

Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Differential contributions of deep and superficial keloid fibroblasts revealed using a novel in vivo model of keloid scar Plast Reconstruct Surg, 129 6, 1259-71

McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2011. Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association, 32 4, 498-508

Powell, Heather M; Armour, Alexis D; Boyce, Steven T 2011. Fluorescein diacetate for determination of cell viability in 3D fibroblast-collagen-GAG constructs. Methods in molecular biology (Clifton, N.J.), 740 , 115-26

Forouzandeh, F.; Jalili, R.B.; Boyce, S.T.; Supp, D.M.; and Ghahary, A. 2010. Local expression of indoleamine 2, 3-dioxygenase (IDO) suppresses T-cell mediated rejection of an engineered bilayered skin substitute. Wound Repair Regen, 18 6, 614-623

Kinneberg, Kirsten R C; Nirmalanandhan, Victor S; Juncosa-Melvin, Natalia; Powell, Heather M; Boyce, Steven T; Shearn, Jason T; Butler, David L 2010. Chondroitin-6-sulfate incorporation and mechanical stimulation increase MSC-collagen sponge construct stiffness. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 28 8, 1092-9

Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601

Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92

Kalyanaraman, Balaji; Boyce, Steven T 2009. Wound healing on athymic mice with engineered skin substitutes fabricated with keratinocytes harvested from an automated bioreactor. The Journal of surgical research, 152 2, 296-302

Powell, Heather M; Boyce, Steven T 2009. Engineered human skin fabricated using electrospun collagen-PCL blends: morphogenesis and mechanical properties. Tissue engineering. Part A, 15 8, 2177-87

Armour, Alexis D; Powell, Heather M; Boyce, Steven T 2008. Fluorescein diacetate for determination of cell viability in tissue-engineered skin. Tissue engineering. Part C, Methods, 14 1, 89-96

Barai, Namrata D; Boyce, Steven T; Hoath, Steven B; Visscher, Marty O; Kasting, Gerald B 2008. Improved barrier function observed in cultured skin substitutes developed under anchored conditions. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 14 4, 418-24

Boyce, S.T.; Simpson, P.S.; and Kagan,R.J. 2008. Survival of burns involving 90% of the total body surface area after treatment with autologous engineered skin substitutes. Proc 26th Army Science Conference; http://www.asc2008.com/manuscripts/L/LO-02.pdf, ,

Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93

McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2008. Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 16 4, 534-41

Powell, H M; Boyce, S T 2008. Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes. Journal of biomedical materials research. Part A, 84 4, 1078-86

Powell,H.M.; Supp,D.M.; Boyce,S.T. 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes Biomaterials, 29 7, 834

Warner, P.; Warden, G.D.; Yakuboff,K.P.; Boyce, S.T.; and Kagan, R.J. 2008. An 18-year experience in the management of congenital nevomelanocytic nevi Ann Plast Surg, 60 3, 283-287

Barai, Namrata D; Supp, Andrew P; Kasting, Gerald B; Visscher, Marty O; Boyce, Steven T 2007. Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice. Skin pharmacology and physiology, 20 1, 21-8

Kalyanaraman,B.; Boyce,S. 2007. Assessment of an automated bioreactor to propagate and harvest keratinocytes for fabrication of engineered skin substitutes Tissue Engineering, 13 5, 983

Powell,H.M.; Boyce,S.T. 2007. Wound closure with edc cross-linked cultured skin substitutes grafted to athymic mice Biomaterials, 28 6, 1084

Barai,N.D.; Supp,A.P.; Kasting,G.B.; Visscher,M.O.; Boyce,S.T. 2006. Improvement of epidermal barrier properties in cultured skin substitutes after grafting onto athymic mice Skin Pharmacology and Physiology, 20 1, 21

Boyce,S.T.; Anderson,B.A.; Rodriguez-Rilo,H.L. 2006. Quantitative assay for quality assurance of human cells for clinical transplantation Cell Transplantation, 15 2, 169

Boyce,S.T.; Kagan,R.J.; Greenhalgh,D.G.; Warner,P.; Yakuboff,K.P.; Palmieri,T.; Warden,G.D. 2006. Cultured skin substitutes reduce requirements for harvesting of skin autograft for closure of excised, full-thickness burns Journal of Trauma - Injury, Infection and Critical Care, 60 4, 821

Powell,H.M.; Boyce,S.T. 2006. EDC cross-linking improves skin substitute strength and stability Biomaterials, 27 34, 5821

Smiley,A.K.; Klingenberg,J.M.; Boyce,S.T.; Supp,D.M. 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting Burns, 32 2, 135

Swope,V.B.; Supp,A.P.; Schwemberger,S.; Babcock,G.; Boyce,S. 2006. Increased expression of integrins and decreased apoptosis correlate with increased melanocyte retention in cultured skin substitutes Pigment Cell Research, 19 5, 424

Smiley,A.K.; Klingenberg,J.M.; Aronow,B.J.; Boyce,S.T.; Kitzmiller,W.J.; Supp,D.M. 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin Journal of Investigative Dermatology, 125 6, 1286

Supp,A.P.; Neely,A.N.; Supp,D.M.; Warden,G.D.; Boyce,S.T. 2005. Evaluation of cytotoxicity and antimicrobial activity of acticoat® burn dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice Journal of Burn Care and Rehabilitation, 26 3, 238

Swope,V.B.; Boyce,S.T. 2005. Differential expression of matrix metalloproteinase-1 in vitro corresponds to tissue morphogenesis and quality assurance of cultured skin substitutes Journal of Surgical Research, 128 1, 79

Passaretti,D.; Billmire,D.; Kagan,R.; Corcoran,J.; Boyce,S. 2004. Autologous cultured skin substitutes conserve donor autograft in elective treatment of congenital giant melanocytic nevus Plastic and Reconstructive Surgery, 114 6, 1523

Supp,D.M.; Karpinski,A.C.; Boyce,S.T. 2004. Expression of human β-defensins hbd-1, hbd-2, and hbd-3 in cultured keratinocytes and skin substitutes Burns, 30 7, 643

Supp,D.M.; Karpinski,A.C.; Boyce,S.T. 2004. Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice Journal of Burn Care and Rehabilitation, 25 4, 337

Holder,I.A.; Durkee,P.; Supp,A.P.; Boyce,S.T. 2003. Assessment of a silver-coated barrier dressing for potential use with skin grafts on excised burns Burns, 29 5, 445

Boyce,S.T.; Kagan,R.J.; Yakuboff,K.P.; Meyer,N.A.; Rieman,M.T.; Greenhalgh,D.G.; Warden,G.D. 2002. Cultured skin substitutes reduce donor skin harvesting for closure of excised, full-thickness burns Annals of Surgery, 235 2, 269

Boyce,S.T.; Supp,A.P.; Swope,V.B.; Warden,G.D. 2002. Vitamin c regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes Journal of Investigative Dermatology, 118 4, 565

Supp,D.M.; Boyce,S.T. 2002. Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes Journal of Burn Care and Rehabilitation, 23 1, 10

Supp,D.M.; Wilson-Landy,K.; Boyce,S.T. 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice FASEB Journal, 16 8, 797

Swope,V.B.; Supp,A.P.; Boyce,S.T. 2002. Regulation of cutaneous pigmentation by titration of human melanocytes in cultured skin substitutes grafted to athymic mice Wound Repair and Regeneration, 10 6, 378

Robb,E.C.; Bechmann,N.; Plessinger,R.T.; Boyce,S.T.; Warden,G.D.; Kagan,R.J. 2001. Storage media and temperature maintain normal anatomy of cadaveric human skin for transplantation to full-thickness skin wounds Journal of Burn Care and Rehabilitation, 22 6, 393

Swope,V.B.; Supp,A.P.; Greenhalgh,D.G.; Warden,G.D.; Boyce,S.T. 2001. Expression of insulin-like growth factor i by cultured skin substitutes does not replace the physiologic requirement for insulin in vitro Journal of Investigative Dermatology, 116 5, 650

Boyce,S.T.; Supp,A.P.; Wickett,R.R.; Hoath,S.B.; Warden,G.D. 2000. Assessment with the dermal torque meter of skin pliability after treatment of burns with cultured skin substitutes Journal of Burn Care and Rehabilitation, 21 1 I, 55

Supp,D.M.; Bell,S.M.; Morgan,J.R.; Boyce,S.T. 2000. Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-a Wound Repair and Regeneration, 8 1, 26

Supp,D.M.; Supp,A.P.; Bell,S.M.; Boyce,S.T. 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor Journal of Investigative Dermatology, 114 1, 5

Boyce, S T 1999. Methods for the Serum-Free Culture of Keratinocytes and Transplantation of Collagen-GAG-Based Skin Substitutes. Methods in molecular medicine, 18 , 365-89

Boyce, S T; Kagan, R J; Meyer, N A; Yakuboff, K P; Warden, G D 1999. The 1999 clinical research award. Cultured skin substitutes combined with Integra Artificial Skin to replace native skin autograft and allograft for the closure of excised full-thickness burns. The Journal of burn care & rehabilitation, 20 6, 453-61

Boyce,S.T.; Supp,A.P.; Swope,V.B.; Warden,G.D. 1999. Topical sulfamylon reduces engraftment of cultured skin substitutes on athymic mice Journal of Burn Care and Rehabilitation, 20 1 I, 33

Holder,I.A.; Boyce,S.T. 1999. Assessment of the potential for microbial resistance to topical use of multiple antimicrobial agents Wound Repair and Regeneration, 7 4, 238

Le Poole,I.C.; Boyce,S.T. 1999. Keratinocytes suppress transforming growth factor-β1 expression by fibroblasts in cultured skin substitutes British Journal of Dermatology, 140 3, 409

Supp,A.P.; Wickett,R.R.; Swope,V.B.; Harriger,M.D.; Hoath,S.B.; Boyce,S.T. 1999. Incubation of cultured skin substitutes in reduced humidity promotes cornification in vitro and stable engraftment in athymic mice Wound Repair and Regeneration, 7 4, 226

Boyce, S.T. 1998. Cultured skin substitutes for treatment of burn wounds Med Res Prog Shriners Hospitals for Children 1998, , 3-8

Can,G.; Abdel-Malek,Z.; Porter-Gill,P.A.; Gill,P.; Boyce,S.; Grabowski,G.A.; Nordlund,J.; Farooqui,J. 1998. Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture Journal of Investigative Dermatology, 111 3, 485

Wang, Q.; Wang, J.J.; Boyce, S.T.; Fischer, J.E.; Hasselgren, P-O. 1998. Endotoxemia and IL-1beta stimulate mucosal IL-6 production in different parts of the gastrointestinal tract J Surg Res, 76 1, 27-31

Wang, Q; Meyer, T A; Boyce, S T; Wang, J J; Sun, X; Tiao, G; Fischer, J E; Hasselgren, P O 1998. Endotoxemia in mice stimulates production of complement C3 and serum amyloid A in mucosa of small intestine The American journal of physiology, 275 5 Pt 2, R1584-92

Boyce,S.T.; Harriger,M.D.; Supp,A.P.; Warden,G.D.; Holder,I.A. 1997. Effective management of microbial contamination in cultured skin substitutes after grafting to athymic mice Wound Repair and Regeneration, 5 2, 191

Harriger, M D; Supp, A P; Swope, V B; Boyce, S T 1997. Reduced engraftment and wound closure of cryopreserved cultured skin substitutes grafted to athymic mice Cryobiology, 35 2, 132-42

Harriger,M.D.; Supp,A.P.; Warden,G.D.; Boyce,S.T. 1997. Glutaraldehyde crosslinking of collagen substrates inhibits degradation in skin substitutes grafted to athymic mice Journal of Biomedical Materials Research, 35 2, 137

Swope,V.B.; Supp,A.P.; Cornelius,J.R.; Babcock,G.F.; Boyce,S.T. 1997. Regulation of pigmentation in cultured skin substitutes by cytometric sorting of melanocytes and keratinocytes Journal of Investigative Dermatology, 109 3, 289

Vicanova ,J.; Ponec, M.; Weerheim, A.; Swope,V.; Westbrook,M.; Harriger,D.; Boyce,S. 1997. Epidermal lipid metabolism of cultured skin substitutes during healing of full-thickness wounds in athymic mice Wound Repair and Regeneration, 5 4, 329

Boyce,S.T.; Supp,A.P.; Harriger,M.D.; Pickens,W.L.; Wickett,R.R.; Hoath,S.B. 1996. Surface electrical capacitance as a no index of epidermal barrier in cultured skin substitutes in athymic mice Journal of Investigative Dermatology, 107 1, 82

Gennari,R.; Alexander,J.W.; Boyce,S.T.; Lilly,N.; Babcock,G.F.; Cornaggia,M. 1996. Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge Shock, 6 2, 95

Goretsky,M.J.; Harriger,M.D.; Supp,A.P.; Greenhalgh,D.G.; Boyce,S.T. 1996. Expression of interleukin-1α, interleukin-6, and basic fibroblast growth factor by cultured skin substitutes before and after grafting to full-thickness wounds in athymic mice Journal of Trauma - Injury, Infection and Critical Care, 40 6, 894

Holder,I.A.; Boyce,S.T. 1996. Formulation of 'idealized' topical antimicrobial mixtures for use with cultured skin grafts Journal of Antimicrobial Chemotherapy, 38 3, 457

Abdel-Malek,Z.; Swope,V.B.; Suzuki,I.; Akcali,C.; Harriger,M.D.; Boyce,S.T.; Urabe,K.; Hearing,V.J. 1995. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides Proceedings of the National Academy of Sciences of the United States of America, 92 5, 1789

Boyce, S.T; Glatter, R.; and Kitzmiller, W.J. 1995. Treatment of chronic wounds with cultured cells and biopolymers: a pilot study Wounds, 7 1, 24-29

Boyce,S.T.; Goretsky,M.J.; Greenhalgh,D.G.; Kagan,R.J.; Rieman,M.T.; Warden,G.D. 1995. Comparative assessment of cultured skin substitutes and native skin autograft for treatment of full-thickness burns Annals of Surgery, 222 6, 743

Boyce,S.T.; Supp,A.P.; Harriger,M.D.; Greenhalgh,D.G.; Warden,G.D. 1995. Topical nutrients promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice Journal of Investigative Dermatology, 104 3, 345

Boyce,S.T.; Warden,G.D.; Holder,I.A. 1995. Cytotoxicity testing of topical antimicrobial agents on human keratinocytes and fibroblasts for cultured skin grafts Journal of Burn Care and Rehabilitation, 16 2 I, 97

Boyce,S.T.; Warden,G.D.; Holder,I.A. 1995. Noncytotoxic combinations of topical antimicrobial agents for use with cultured skin substitutes Antimicrobial Agents and Chemotherapy, 39 6, 1324

Farooqui,J.Z.; Robb,E.; Boyce,S.T.; Warden,G.D.; Nordlund,J.J. 1995. Isolation of a unique melanogenic inhibitor from human skin xenografts: initial in vitro and in vivo characterization Journal of Investigative Dermatology, 104 5, 739

Goretsky, M J; Breeden, M; Pisarski, G; Harriger, M D; Boyce, S T; Greenhalgh, D G 1995. Capillary morphogenesis during healing of full-thickness skin grafts: an ultrastructural study Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 3 2, 213-20

Goretsky, M J; Supp, A P; Greenhalgh, D G; Warden, G D; Boyce, S T 1995. Surface electrical capacitance as an index of epidermal barrier properties of composite skin substitutes and skin autografts Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 3 4, 419-25

Harriger,M.D.; Warden,G.D.; Greenhalgh,D.G.; Kagan,R.J.; Boyce,S.T. 1995. Pigmentation and microanatomy of skin regenerated from composite grafts of cultured cells and biopolymers applied to full-thickness burn wounds Transplantation, 59 5, 702

Boyce,S.T.; Holder,I.A.; Supp,A.P.; Warden,G.D.; Greenhalgh,D.G. 1994. Delivery and activity of antimicrobial drugs released from human fibrin sealant Journal of Burn Care and Rehabilitation, 15 3, 251

Holder,I.A.; Boyce,S.T. 1994. Agar well diffusion assay testing of bacterial susceptibility to various antimicrobials in concentrations non-toxic for human cells in culture Burns, 20 5, 426

Krueger, G G; Morgan, J R; Jorgensen, C M; Schmidt, L; Li, H L; Kwan, M K; Boyce, S T; Wiley, H S; Kaplan, J; Petersen, M J 1994. Genetically modified skin to treat disease: potential and limitations. The Journal of investigative dermatology, 103 5 Suppl, 76S-84S

Boyce,S.T.; Greenhalgh,D.G.; Kagan,R.J.; Housinger,T.; Sorrell,J.M.; Childress,C.P.; Rieman,M.; Warden,G.D. 1993. Skin anatomy and antigen expression after burn wound closure with composite grafts of cultured skin cells and biopolymers Plastic and Reconstructive Surgery, 91 4, 632

Boyce,S.T.; Holder,I.A. 1993. Selection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity Plastic and Reconstructive Surgery, 92 3, 493

Boyce,S.T.; Medrano,E.E.; Abdel-Malek,Z.; Supp,A.P.; Dodick,J.M.; Nordlund,J.J.; Warden,G.D. 1993. Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice Journal of Investigative Dermatology, 100 4, 360

Boyce,S.T.; Supp,A.P.; Warden,G.D.; Holder,I.A. 1993. Attachment of an aminoglycoside, amikacin, to implantable collagen for local delivery in wounds Antimicrobial Agents and Chemotherapy, 37 9, 1890

Boyce,S.T.; Williams,M.L. 1993. Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin Journal of Investigative Dermatology, 101 2, 180

Hoath,S.B.; Tanaka,R.; Boyce,S.T. 1993. Stratum corneum formation in the perinatal rat Journal of Investigative Dermatology, 100 4, 400

Porembka, D.T.; Kier, A; Sehlhorst, S; Boyce, S; Orlowski, J.P; and Davis, K. 1993. The pathophysiologic changes following bile aspiration in a porcine lung model Chest, 104 3, 919-924

Boyce, S T; Stompro, B E; Hansbrough, J F 1992. Biotinylation of implantable collagen for drug delivery. Journal of biomedical materials research, 26 4, 547-53

Boyce,S.T.; Foreman,T.J.; Furmanski,P.; Hansbrough,J.F. 1992. Absence of tumorigenicity in athymic mice by normal human epidermal keratinocytes after culture in serum-free medium Cancer Letters, 62 2, 141

Boyce, S T; Foreman, T J; English, K B; Stayner, N; Cooper, M L; Sakabu, S; Hansbrough, J F 1991. Skin wound closure in athymic mice with cultured human cells, biopolymers, and growth factors. Surgery, 110 5, 866-76

Cooper,M.L.; Spielvogel,R.L.; Hanbrough,J.F.; Boyce,S.T.; Frank,D.H. 1991. Reconstitution of the histologic characteristics of a giant congenital nevomelanocytic nevus employing the athymic mouse and a cultured skin substitute Journal of Investigative Dermatology, 97 4, 649

Kuroiwa,K.; Nelson,J.L.; Boyce,S.T.; Alexander,J.W.; Ogle,C.K.; Inoue,S. 1991. Metabolic and immune effect of vitamin e supplementation after burn Journal of Parenteral and Enteral Nutrition, 15 1, 22

Sakai, J; Hung, J; Zhu, G; Cardell, R; Boyce, S; Kao, WW-Y 1991. Collagen metabolism during healing of lacerated rabbit corneas. Exptl Eye Res, 52 , 237-244

Alexander, J W; Boyce, S T; Babcock, G F; Gianotti, L; Peck, M D; Dunn, D L; Pyles, T; Childress, C P; Ash, S K 1990. The process of microbial translocation. Annals of surgery, 212 4, 496-510; discussion

Cooper, M L; Boyce, S T; Hansbrough, J F; Foreman, T J; Frank, D H 1990. Cytotoxicity to cultured human keratinocytes of topical antimicrobial agents. The Journal of surgical research, 48 3, 190-5

Boyce, S T; Cooper, M L; Foreman, T J; Stompro B E; Hansbrough, J F. 1989. Serum-free culture of human epidermal keratinocytes and application to skin substitutes. Proceedings of the Second Bioscience Conference, Tokyo Metropolitan University, Tokyo, Japan, , 18-27

Hansbrough,J.F.; Boyce,S.T.; Cooper,M.L.; Foreman,T.J. 1989. Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate Journal of the American Medical Association, 262 15, 2125

Stompro,B.E.; Hansbrough,J.F.; Boyce,S.T. 1989. Attachment of peptide growth factors to implantable collagen Journal of Surgical Research, 46 5, 413

Boyce, S T; Christianson, D J; Hansbrough, J F 1988. Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes. Journal of biomedical materials research, 22 10, 939-57

Boyce, S T; Hansbrough, J F 1988. Biologic attachment, growth, and differentiation of cultured human epidermal keratinocytes on a graftable collagen and chondroitin-6-sulfate substrate. Surgery, 103 4, 421-31

Boyce,S.T.; Glafkides,M.C.; Foreman,T.J.; Hansbrough,J.F. 1988. Reduced wound contraction after grafting of full-thickness burns with a collagen and chondroitin-6-sulfate (gag) dermal skin substitute and coverage with biobrane Journal of Burn Care and Rehabilitation, 9 4, 364

Boyce ST 1987. Medical and biological criteria for preparation from cultured keratinocytes and a collagen-chondroitin-sulfate membrane of a human skin replacement for treatment of full-thickness skin loss injuries. Proceedings of the 17th World Congress on Dermatology Workshop-14, , 210

Wikner, N E; Huff, J C; Norris, D A; Boyce, S T; Cary, M; Kissinger, M; Weston, W L 1986. Study of HLA-DR synthesis in cultured human keratinocytes. The Journal of investigative dermatology, 87 5, 559-64

Boyce, ST; Ham, RG 1985. Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media. J Tiss Cult Meth, 9 2, 83-93

Norris, D A; Ryan, S B; Kissinger, R M; Fritz, K A; Boyce, S T 1985. Systematic comparison of antibody-mediated mechanisms of keratinocyte lysis in vitro. Journal of immunology (Baltimore, Md. : 1950), 135 2, 1073-9

Hansbrough JF; Boyce ST 1984. What criteria should be used for designing artificial skin replacements and how well do the current materials meet these criteria. J. Trauma, 24 9 Supplement, S31-S35

LeFeber, W P; Norris, D A; Ryan, S R; Huff, J C; Lee, L A; Kubo, M; Boyce, S T; Kotzin, B L; Weston, W L 1984. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. The Journal of clinical investigation, 74 4, 1545-51

Boyce,S.T.; Ham,R.G. 1983. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture Journal of Investigative Dermatology, 81 1 Suppl., 33S

Bettger, W J; Boyce, S T; Walthall, B J; Ham, R G 1981. Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone. Proceedings of the National Academy of Sciences of the United States of America, 78 9, 5588-92

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207. Boyce ST, Simpson PS, Rieman MT, Warner P, Yakuboff KP, Bailey JK, Nelson JK, Fowler LA, Kagan RJ 2015. Autologous engineered skin substitutes reduce mortality and harvesting of skin graft donor sites for closure of extensive, full-thickness burns. J Burn Care Res , 36 3, S107


Boyce ST, C Lloyd, R Zimmerman, and DM Supp 2015. Regulation of pigmentation in engineered skin substitutes. Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), Investigators Meeting; Bethesda, MD., ,


Boyce ST, CM Lloyd, RL Zimmerman, and DM Supp 2015. Restoration of skin color by human melanocytes in engineered skin substitutes grafted to full-thickness wounds. J Burn Care Res, 36 3, S83


Supp DM, JM Hahn, ST Boyce, and KL McFarland 2015. Involvement of TGF-β1-mediated epithelial-mesenchymal transition in keloid scarring. J Burn Care Res, 36 3, S84


Supp DM, JM Hahn, K Glaser, KL McFarland, ST Boyce, BJ Aronow, and RJ Kagan 2013. Keloid keratinocytes altered expression of genes involved in differentiation, adhesion, and epithelial-mesenchymal transition. J Burn Care Res, 34 2, S94


Boyce ST, KA Lynch, RL Zimmerman, and DM Supp 2012. Transition to Technology Readiness Level 5 of engineered skin substitutes with pigment: scientific, regulatory and institutional considerations. Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; St. Pete’s Beach, FL., ,


Boyce ST, MT Rieman, and RJ Kagan 2012. Reduced mortality in pediatric burn patients treated with autologous cultured skin substitutes during an FDA Integrity Hold. Proceedings of an FDA Public Workshop on Medical Countermeasures for a Burn Mass Casualty Incident. , ,


Chavez-Munoz C, R Hartwell, RB Jalili, ST Boyce, and A Ghahary 2012. Functioning of IDO-expressing engineered skin composite in a fibrotic animal model. J Burn Care Res , 33 2, S64


Rieman MT, A Neeley, ST Boyce, and RJ Kagan 2012. Amish Burn Wound Ointment (ABWO) and burdock leaf dressings: assessments of antimicrobial & cytotoxic activities. J Burn Care Res, 33 2, S142


Supp DM, JM Hahn, K Glaser, KL McFarland, and ST Boyce 2012. Distinct phenotypes of deep vs. superficial keloid fibroblasts in keloid skin substitutes transplanted to athymic mice. J Burn Care Res, 33 2, S64


Boyce ST, KA Lynch, RL Zimmerman, DM Supp, and RJ Kagan 2011. Flow cytometry for regulation of melanocyte density in engineered skin substitutes. Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; , ,


Boyce ST, RL Zimmerman, DM Supp, and RJ Kagan 2011. Tumorigenicity testing of human melanocytes for engineered skin substitutes. Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; , ,


Boyce ST, RL Zimmerman, KA Lynch, DM Supp, and RJ Kagan 2011. Regulation of skin pigmentation in engineered skin substitutes Proc Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting; , ,


Glaser K, JM Hahn, KL McFarland, ST Boyce, and DM Supp 2011. Abnormal responses of keloid tissue to wounding identified using an in vitro model system. Wound Repair Regen , 19 2, A24


McFarland KL, K Glaser, JM Hahn, ST Boyce, and DM Supp 2011. Culture medium formulation and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. J Burn Care Res, 32 2, S177


Sriwiriyanont P, EA Maier, KA Lynch, DM Supp, and ST Boyce 2011. Dermal papilla cells promote trichogenesis in engineered skin substitutes. J Invest Dermatol , 131 , S79


Boyce ST, AP Supp, RK Rice, VB Swope, DM Supp, and RJ Kagan 2010. Pulse-chase assessment of label-retaining keratinocytes in engineered skin substitutes after grafting to athymic mice J Burn Care Res , 31 2, S54


Boyce ST, J Pruszka, M Lockhard, M Estes, M Rust, DM supp and RJ Kagan 2010. Formation of vascular channels in engineered skin substitutes Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting, ,


Boyce ST, R Zimmerman, VB Swope, DM Supp and RJ Kagan 2010. Regulation of pigmentation in engineered skin substitutes Annual report of the Armed Forces Institute for Regenerative Medicine (AFIRM), All Hands Meeting, ,


Supp DM, JM Klingenberg, KL McFarland, K Glaser, ST Boyce, K Bailey, K Yakuboff, P Warner, and RJ Kagan 2010. Engineered skin as an organotypic model for keloid scarring J Burn Care Res, 31 2, S53