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Photo of  Foong-Yen Lim, MD

Foong-Yen Lim, MD

Professor of Clinical-Affiliate

Surgical Director of Cincinnati Fetal Center

Surgery | College of Medicine

Education/Credentials
  • Pediatric Surgery Fellowship: Children's Hospital of Philadelphia
  • General Surgery Residency: Penn State Milton S. Hershey Medical Center
  • Pediatric Surgery Research and Fetal Surgery Fellowship: Children's Hospital of Philadelphia
  • Medical Degree: Medical University of South Carolina
  • Bachelor's Degree: Graceland College
Contact Information
Research Interests

Fetal Surgery, Neonatal Lung Malformations, Diaphragmatic Hernia

Peer Reviewed Publications

Chiu, Joanne S; Ma, Lijiang; Wynn, Julia; Krishnan, Usha; Rosenzweig, Erika B; Aspelund, Gudrun; Arkovitz, Marc; Warner, Brad W; Lim, Foong-Yen; Mychaliska, George B; Azarow, Kenneth; Cusick, Robert A; Chung, Dai H; Chung, Wendy K 2017. Mutations in BMPR2 are not present in patients with pulmonary hypertension associated with congenital diaphragmatic hernia. Journal of pediatric surgery, ,

Farkouh-Karoleski, Christiana; Najaf, Tasnim; Wynn, Julia; Aspelund, Gudrun; Chung, Wendy K; Stolar, Charles J; Mychaliska, George B; Warner, Brad W; Wagner, Amy J; Cusick, Robert A; Lim, Foong-Yen; Schindel, David T; Potoka, Douglas; Azarow, Kenneth; Cotten, C Michael; Hesketh, Anthony; Soffer, Samuel; Crombleholme, Timothy; Needelman, Howard 2017. A definition of gentle ventilation in congenital diaphragmatic hernia: a survey of neonatologists and pediatric surgeons. Journal of perinatal medicine, ,

Coleman, Alan; Kline-Fath, Beth; Stanek, Jerzy; Lim, Foong-Yen 2016. Pleuropulmonary Blastoma in a Neonate Diagnosed Prenatally as Congenital Pulmonary Airway Malformation. Fetal diagnosis and therapy, 39 3, 234-7

Emery, Stephen P; Hasley, Steve K; Catov, Janet M; Miller, Russell S; Moon-Grady, Anita J; Baschat, Ahmet A; Johnson, Anthony; Lim, Foong-Yen; Gagnon, Alain L; O'Shaughnessy, Richard W; Ozcan, Tulin; Luks, Francois I 2016. North American Fetal Therapy Network: intervention vs expectant management for stage I twin-twin transfusion syndrome. American journal of obstetrics and gynecology, 215 3, 346.e1-7

Johnston, Jennifer H; Kline-Fath, Beth M; Bitters, Constance; Calvo-Garcia, Maria A; Lim, Foong-Yen Y 2016. Congenital overinflation: prenatal MRI and US findings and outcomes. Prenatal diagnosis, 36 6, 568-75

Akinkuotu, Adesola C; Coleman, Alan; Shue, Eveline; Sheikh, Fariha; Hirose, Shinjiro; Lim, Foong-Yen; Olutoye, Oluyinka O 2015. Predictors of poor prognosis in prenatally diagnosed sacrococcygeal teratoma: A multiinstitutional review. Journal of pediatric surgery, 50 5, 771-4

Azarow, Kenneth S; Cusick, Robert; Wynn, Julia; Chung, Wendy; Mychaliska, George B; Crombleholme, Timothy M; Chung, Dai H; Lim, Foong Yen; Potoka, Douglas; Warner, Brad W; Aspelund, Gundrun; Arkovitz, Marc S 2015. The association between congenital diaphragmatic hernia and undescended testes. Journal of pediatric surgery, 50 5, 744-5

Coleman, Alan M; Merrow, Arnold C; Crombleholme, Timothy M; Jaekle, Ronald; Lim, Foong-Yen 2015. Fetal MRI of Torsed Bronchopulmonary Sequestration with Tension Hydrothorax and Hydrops in a Twin Gestation. Fetal diagnosis and therapy, ,

Coleman, Alan; Phithakwatchara, Nisarat; Shaaban, Aimen; Keswani, Sundeep; Kline-Fath, Beth; Kingma, Paul; Haberman, Beth; Lim, Foong-Yen 2015. Fetal lung growth represented by longitudinal changes in MRI-derived fetal lung volume parameters predicts survival in isolated left-sided congenital diaphragmatic hernia. Prenatal diagnosis, 35 2, 160-6

Lim, Foong-Yen; Coleman, Alan; Polzin, William; Jaekle, Ronald; Habli, Mounira; Van Hook, James; Lewis, David; Crombleholme, Timothy 2015. Giant chorioangiomas: perinatal outcomes and techniques in fetoscopic devascularization. Fetal diagnosis and therapy, 37 1, 18-23

Michelfelder, Erik; Tan, Xiao; Cnota, James; Divanovic, Allison; Statile, Christopher; Lim, Foong-Yen; Crombleholme, Timothy 2015. Prevalence, Spectrum, and Outcome of Right Ventricular Outflow Tract Abnormalities in Twin-twin Transfusion Syndrome: A Large, Single-center Experience. Congenital heart disease, 10 3, 209-18

Phithakwatchara, Nisarat; Coleman, Alan; Peiro, Jose L; Lee, Amanda E; Keswani, Sundeep G; Kline-Fath, Beth; Lim, Foong-Yen; Shaaban, Aimen F 2015. Differential patterns of prenatal ipsilateral and contralateral lung growth in cases of isolated left-sided congenital diaphragmatic hernia. Prenatal diagnosis, ,

Phithakwatchara, Nisarat; Coleman, Alan; Peiro, Jose L; Lee, Amanda E; Keswani, Sundeep G; Kline-Fath, Beth; Lim, Foong-Yen; Shaaban, Aimen F 2015. Expanded intrathoracic space in fetal cases of isolated congenital diaphragmatic hernia contributes to disparity between percent predicted lung volume and observed to expected total lung volume. Prenatal diagnosis, 35 2, 154-9

Radhakrishnan, Rupa; Calvo-Garcia, Maria A; Lim, Foong-Yen; Elluru, Ravindhra G; Koch, Bernadette L 2015. Congenital salivary gland anlage tumor - in utero and postnatal imaging. Pediatric radiology, 45 3, 453-6

Votava-Smith, Jodie K; Habli, Mounira; Cnota, James F; Divanovic, Allison; Polzin, William; Lim, Foong-Yen; Michelfelder, Erik C 2015. Diastolic dysfunction and cerebrovascular redistribution precede overt recipient twin cardiomyopathy in early-stage twin-twin transfusion syndrome. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 28 5, 533-40

Calvo-Garcia, Maria A; Kline-Fath, Beth M; Adams, Denise M; Gupta, Anita; Koch, Bernadette L; Lim, Foong-Yen; Laor, Tal 2014. Imaging evaluation of fetal vascular anomalies. Pediatric radiology, ,

Calvo-Garcia, Maria A; Lim, Foong-Yen; Stanek, Jerzy; Bitters, Constance; Kline-Fath, Beth M 2014. Congenital peribronchial myofibroblastic tumor: prenatal imaging clues to differentiate from other fetal chest lesions. Pediatric radiology, 44 4, 479-83

Coleman, Alan M; Calvo-Garcia, Maria A; Zbojniewicz, Andrew M; Alonso, Maria; Lim, Foong-Yen 2014. Prenatal Diagnosis of Infantile Myofibroma with Postnatal Imaging Correlation. Fetal diagnosis and therapy, ,

Coleman, Alan; Habli, Mounira; Hinton, Robert B; Polzin, William; Lim, Foong-Yen 2014. Altered amniotic fluid leptin levels in twin-twin transfusion syndrome with concurrent placental insufficiency. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, , 1-6

Coleman, Alan; Shaaban, Aimen; Keswani, Sundeep; Lim, Foong-Yen 2014. Sacrococcygeal teratoma growth rate predicts adverse outcomes. Journal of pediatric surgery, 49 6, 985-9

Weaver, K Nicole; Johnson, Jodie; Kline-Fath, Beth; Zhang, Xue; Lim, Foong-Yen; Tinkle, Brad; Saal, Howard M; Hopkin, Robert J 2014. Predictive value of fetal lung volume in prenatally diagnosed skeletal dysplasia. Prenatal diagnosis, 34 13, 1326-31

Yu, Lan; Bennett, James T; Wynn, Julia; Carvill, Gemma L; Cheung, Yee Him; Shen, Yufeng; Mychaliska, George B; Azarow, Kenneth S; Crombleholme, Timothy M; Chung, Dai H; Potoka, Douglas; Warner, Brad W; Bucher, Brian; Lim, Foong-Yen; Pietsch, John; Stolar, Charles; Aspelund, Gudrun; Arkovitz, Marc S ; Mefford, Heather; Chung, Wendy K 2014. Whole exome sequencing identifies de novo mutations in GATA6 associated with congenital diaphragmatic hernia. Journal of medical genetics, 51 3, 197-202

Calvo-Garcia, Maria A; Kline-Fath, Beth M; Rubio, Eva I; Merrow, Arnold C; Guimaraes, Carolina V; Lim, Foong-Yen 2013. Fetal MRI of cloacal exstrophy. Pediatric radiology, 43 5, 593-604

Coleman, Alan M; Merrow, Arnold C; Elluru, Ravindhra G; Polzin, William J; Lim, Foong-Yen 2013. Tracheal agenesis with tracheoesophageal fistulae: fetal MRI diagnosis with confirmation by ultrasound during an ex utero intrapartum therapy (EXIT) delivery and postdelivery MRI. Pediatric radiology, 43 10, 1385-90

Coleman, Alan; Kline-Fath, Beth; Keswani, Sundeep; Lim, Foong-Yen 2013. Prenatal solid tumor volume index: novel prenatal predictor of adverse outcome in sacrococcygeal teratoma. The Journal of surgical research, 184 1, 330-6

Cost, Nicholas G; Geller, James I; Le, Louis D; Crombleholme, Timothy M; Keswani, Sundeep G; Lim, Foong-Yen; Alam, Shumyle 2013. Urologic co-morbidities associated with sacrococcygeal teratoma and a rational plan for urologic surveillance. Pediatric blood & cancer, 60 10, 1626-9

Landis, Melissa W; Butler, Dawn; Lim, Foong Yen; Keswani, Sundeep; Frischer, Jason; Haberman, Beth; Kingma, Paul S 2013. Octreotide for chylous effusions in congenital diaphragmatic hernia. Journal of pediatric surgery, 48 11, 2226-9

Ngamprasertwong, Pornswan; Habli, Mounira; Boat, Anne; Lim, Foong Yen; Esslinger, Hope; Ding, Lili; Sadhasivam, Senthilkumar 2013. Maternal hypotension during fetoscopic surgery: incidence and its impact on fetal survival outcomes. TheScientificWorldJournal, 2013 , 709059

Wolfe, Katherine; Lewis, David; Witte, David; Kline-Fath, Beth; Lim, Foong-Yen; Jaekle, Ronald; Habli, Mounira; Hostiuck, Judith; Baregamian, Naira; Keswani, Sundeep; Crombleholme, Timothy 2013. Fetal cervical teratoma: What is the role of fetal MRI in predicting pulmonary hypoplasia? Fetal diagnosis and therapy, 33 4, 252-6

Wynn, Julia; Aspelund, Gudrun; Zygmunt, Annette; Stolar, Charles J H; Mychaliska, George; Butcher, Jennifer; Lim, Foong-Yen; Gratton, Teresa; Potoka, Douglas; Brennan, Kate; Azarow, Ken; Jackson, Barbara; Needelman, Howard; Crombleholme, Timothy; Zhang, Yuan; Duong, Jimmy; Arkovitz, Marc S; Chung, Wendy K; Farkouh, Christiana 2013. Developmental outcomes of children with congenital diaphragmatic hernia: a multicenter prospective study. Journal of pediatric surgery, 48 10, 1995-2004

Yu, Lan; Wynn, Julia; Cheung, Yee Him; Shen, Yufeng; Mychaliska, George B; Crombleholme, Timothy M; Azarow, Kenneth S; Lim, Foong Yen; Chung, Dai H; Potoka, Douglas; Warner, Brad W; Bucher, Brian; Stolar, Charles; Aspelund, Gudrun; Arkovitz, Marc S; Chung, Wendy K 2013. Variants in GATA4 are a rare cause of familial and sporadic congenital diaphragmatic hernia. Human genetics, 132 3, 285-92

Bischoff, Andrea; Calvo-Garcia, Maria A; Baregamian, Naira; Levitt, Marc A; Lim, Foong-Yen; Hall, Jennifer; Peña, Alberto 2012. Prenatal counseling for cloaca and cloacal exstrophy-challenges faced by pediatric surgeons. Pediatric surgery international, 28 8, 781-8

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Katz, Anna B; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M 2012. Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis. PloS one, 7 8, e43633

Le, Louis D; Keswani, Sundeep G; Biesiada, Jacek; Lim, Foong-Yen; Kingma, Paul S; Haberman, Beth E; Frischer, Jason; Habli, Mounira; Crombleholme, Timothy M 2012. The congenital diaphragmatic hernia composite prognostic index correlates with survival in left-sided congenital diaphragmatic hernia. Journal of pediatric surgery, 47 1, 57-62

Neuman, Jeremy; Calvo-Garcia, Maria A; Kline-Fath, Beth M; Bitters, Constance; Merrow, Arnold C; Guimaraes, Carolina V A; Lim, Foong-Yen 2012. Prenatal imaging of amniotic band sequence: utility and role of fetal MRI as an adjunct to prenatal US. Pediatric radiology, 42 5, 544-51

Pokall, Stefan; Maldonado, Arturo R; Klanke, Charles A; Katayama, Shuichi; Morris, Lee M; Vuletin, Jose F; Lim, Foong-Yen; Crombleholme, Timothy M 2012. Compensatory lung growth in NOS3 knockout mice suggests synthase isoform redundancy. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie, 22 2, 148-56

Yu, Lan; Wynn, Julia; Ma, Lijiang; Guha, Saurav; Mychaliska, George B; Crombleholme, Timothy M; Azarow, Kenneth S; Lim, Foong Yen; Chung, Dai H; Potoka, Douglas; Warner, Brad W; Bucher, Brian; LeDuc, Charles A; Costa, Katherine; Stolar, Charles; Aspelund, Gudrun; Arkovitz, Marc S; Chung, Wendy K 2012. De novo copy number variants are associated with congenital diaphragmatic hernia. Journal of medical genetics, 49 10, 650-9

Calvo-Garcia, Maria A; Kline-Fath, Beth M; Levitt, Marc A; Lim, Foong-Yen; Linam, Leann E; Patel, Manish N; Kraus, Steven; Crombleholme, Timothy M; Peña, Alberto 2011. Fetal MRI clues to diagnose cloacal malformations. Pediatric radiology, 41 9, 1117-28

Guimaraes, Carolina V A; Kline-Fath, Beth M; Linam, Leann E; Garcia, Maria A Calvo; Rubio, Eva I; Lim, Foong-Yen 2011. MRI findings in multifetal pregnancies complicated by twin reversed arterial perfusion sequence (TRAP). Pediatric radiology, 41 6, 694-701

Keswani, Sundeep G; Le, Louis D; Morris, Lee M; Lim, Foong-Yen; Katz, Anna B; Ghobril, Nabil; Habli, Mounira; Frischer, Jason S; Crombleholme, Timothy M 2011. Submucosal gland development in the human fetal trachea xenograft model: implications for fetal gene therapy. Journal of pediatric surgery, 46 1, 33-8

Le, Louis D; Alam, Shumyle; Lim, Foong-Yen; Keswani, Sundeep G; Crombleholme, Timothy M 2011. Prenatal and postnatal urologic complications of sacrococcygeal teratomas. Journal of pediatric surgery, 46 6, 1186-90

Bischoff, Andrea; Levitt, Marc A; Lim, Foong Yen; Guimarães, Carolina; Peña, Alberto 2010. Prenatal diagnosis of cloacal malformations. Pediatric surgery international, 26 11, 1071-5

Crombleholme, Timothy M; Lim, Foong-Yen; Habli, Mounira; Polzin, William; Jaekle, Ronald; Michelfelder, Erik; Cnota, James; Liu, Chunyan; Kim, Mi-Ok 2010. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. American journal of obstetrics and gynecology, 203 4, 397.e1-9

Habli, Mounira; Cnota, James; Michelfelder, Erik; Salisbury, Shelia; Schnell, Beverly; Polzin, William; Lim, Foong Yen; Crombleholme, Timothy M 2010. The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome. American journal of obstetrics and gynecology, 203 4, 404.e1-7

Vuletin, Jose F; Lim, Foong-Yen; Cnota, James; Kline-Fath, Beth; Salisbury, Shelia; Haberman, Beth; Kingma, Paul; Frischer, Jason; Crombleholme, Timothy 2010. Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia. Journal of pediatric surgery, 45 4, 703-8

Habli, Mounira; Bombrys, Annette; Lewis, David; Lim, Foong-Yen; Polzin, William; Maxwell, Rose; Crombleholme, Timothy 2009. Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience. American journal of obstetrics and gynecology, 201 4, 417.e1-7

Habli, Mounira; Lim, Foong Yen; Crombleholme, Timothy 2009. Twin-to-twin transfusion syndrome: a comprehensive update. Clinics in perinatology, 36 2, 391-416, x

Morris, Lee M; Lim, Foong-Yen; Crombleholme, Timothy M 2009. Ex utero intrapartum treatment procedure: a peripartum management strategy in particularly challenging cases. The Journal of pediatrics, 154 1, 126-131.e3

Morris, Lee M; Lim, Foong-Yen; Elluru, Ravindhra G; Hopkin, Robert J; Jaekle, Ronald K; Polzin, William J; Crombleholme, Timothy M 2009. Severe micrognathia: indications for EXIT-to-Airway. Fetal diagnosis and therapy, 26 3, 162-6

Morris, Lee M; Lim, Foong-Yen; Livingston, Jeffrey C; Polzin, William J; Crombleholme, Timothy M 2009. High-risk fetal congenital pulmonary airway malformations have a variable response to steroids. Journal of pediatric surgery, 44 1, 60-5

Vaikunth, Sachin S; Morris, Lee M; Polzin, William; Gottliebson, William; Lim, Foong-Yen; Kline-Faith, Beth; Crombleholme, Timothy M 2009. Congenital high airway obstruction syndrome due to complete tracheal agenesis: an accident of nature with clues for tracheal development and lessons in management. Fetal diagnosis and therapy, 26 2, 93-7

Habli, Mounira; Livingston, Jeffrey; Harmon, Jeffery; Lim, Foong Yen; Plozin, William; Crombleholme, Timothy 2008. The outcome of twin-twin transfusion syndrome complicated with placental insufficiency. American journal of obstetrics and gynecology, 199 4, 424.e1-6

Habli, Mounira; Michelfelder, Erik; Livingston, Jeffrey; Harmon, Jeffrey; Lim, Foong Yen; Polzin, William; Crombleholme, Timothy 2008. Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome. American journal of obstetrics and gynecology, 199 4, 412.e1-6

Adibe, Obinna O; Nichol, Peter F; Lim, Foong-Yen; Mattei, Peter 2007. Ad libitum feeds after laparoscopic pyloromyotomy: a retrospective comparison with a standardized feeding regimen in 227 infants. Journal of laparoendoscopic & advanced surgical techniques. Part A, 17 2, 235-7

Livingston, Jeffrey C; Lim, Foong-Yen; Polzin, William; Mason, Jennifer; Crombleholme, Timothy M 2007. Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experience. American journal of obstetrics and gynecology, 197 4, 399.e1-3

Livingston, Jeffrey C; Malik, Khurram M; Crombleholme, Timothy M; Lim, Foong-Yen; Sibai, Baha M 2007. Mirror syndrome: a novel approach to therapy with fetal peritoneal-amniotic shunt. Obstetrics and gynecology, 110 2 Pt 2, 540-3

Wilson, R Douglas; Pawel, Bruce; Bebbington, Michael; Johnson, Mark P; Lim, Foong-Yen; Stamilio, David; Silber, Angela; Zakii, Elaine; Flake, Alan W 2006. Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion. Prenatal diagnosis, 26 11, 1058-61

Liu, Steven; de Blacam, Catherine; Lim, Foong-Yen; Mattei, Peter; Mamula, Petar 2005. Magnetic foreign body ingestions leading to duodenocolonic fistula. Journal of pediatric gastroenterology and nutrition, 41 5, 670-2

Lim, Foong-Yen; Crombleholme, Timothy M; Hedrick, Holly L; Flake, Alan W; Johnson, Mark P; Howell, Lori J; Adzick, N Scott 2003. Congenital high airway obstruction syndrome: natural history and management. Journal of pediatric surgery, 38 6, 940-5

Lim, Foong-Yen; Kobinger, Gary P; Weiner, Daniel J; Radu, Antoneta; Wilson, James M; Crombleholme, Timothy M 2003. Human fetal trachea-SCID mouse xenografts: efficacy of vesicular stomatitis virus-G pseudotyped lentiviral-mediated gene transfer. Journal of pediatric surgery, 38 6, 834-9

Lim, Foong-Yen; Martin, Bernard G; Sena-Esteves, Miguel; Radu, Antoneta; Crombleholme, Timothy M 2002. Adeno-associated virus (AAV)-mediated gene transfer in respiratory epithelium and submucosal gland cells in human fetal tracheal organ culture. Journal of pediatric surgery, 37 7, 1051-7; discussion 1

Guimaraes, Carolina V A; Linam, Leann E; Kline-Fath, Beth M; Donnelly, Lane F; Calvo-Garcia, Maria A; Rubio, Eva I; Livingston, Jeffrey C; Hopkin, Robert J; Peach, Elizabeth; Lim, Foong-Yen; Crombleholme, Timothy M . Prenatal MRI findings of fetuses with congenital high airway obstruction sequence. Korean journal of radiology, 10 2, 129-34

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M . Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 592-600

Keswani, Sundeep G; Katz, Anna B; Lim, Foong-Yen; Zoltick, Philip; Radu, Antoneta; Alaee, Datis; Herlyn, Meenhard; Crombleholme, Timothy M . Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 12 5, 497-504

Morris, Lee M; Klanke, Charles A; Lang, Stephanie A; Pokall, Stefan; Maldonado, Arturo R; Vuletin, Jose F; Alaee, Datis; Keswani, Sundeep G; Lim, Foong-Yen; Crombleholme, Timothy M . Characterization of endothelial progenitor cells mobilization following cutaneous wounding. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 18 4, 383-90