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Pharmacology: Dissertation Research

Careers & Alumni in Pharmacology

Physiology: Dissertation Research

Careers & Alumni in Physiology

 

 

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Faculty Research 

Guochang Fan, PhD
Department of Pharmacology & Systems Physiology

Regulatory roles of microRNAs and exosome signaling pathway in sepsis-, diabetes- and infarction-induced heart failure; 2) protective roles of stem cell-derived exosomes in cardiovascular disease; and 3) the influence of microRNAs on bone marrow-derived mesenchymal stem cell behavior 

James Herman, PhD
Department of Pharmacology & Systems Physiology

1) limbic system regulation of the stress response and, consequently, on the generation of stress-related disorders, ranging from major depressive illness to essential hypertension to neurodegeneration and aging, and
2) defining the role of central adrenocorticosteroid receptors in transducing stress-related signals in normal physiology, aging and disease states.

Andy Norman, PhD
Department of Pharmacology & Systems Physiology

Development of quantitative pharmacological models of addictive behavior. These models can then be used to predict the clinical efficacy of potential medications for the treatment of cocaine and other addictions. Dr. Norman leads a multidisciplinary team that is developing human anti-cocaine monoclonal antibodies suitable for use as therapeutic agents for the prevention of relapse in cocaine addicts.

Hong-Sheng Wang, PhD
Department of Pharmacology & Systems Physiology

We are interested in the impact of environmental pollutants on the heart and circulatory system. We use a combination of pharmacology, toxicology, cardiac physiology and electrophysiology techniques to address how environmental chemicals may contribute to abnormal heart function, arrhythmias, and excessive blood coagulation. We are also interested in cardiac ion channels and how they contribute to heart physiology and diseases.

Tongli Zhang, PhD
Department of Pharmacology & Systems Physiology

In my research, I combine biological intuition with mathematical modeling to make clear the seemingly confusing networks. My biological intuition is on cell cycle, apoptosis, p53 pathway and NF-κB pathway. My modeling expertise is on positive feedbacks, negative feedbacks, switches, and oscillations. 

Zalfa Abdel-Malek, PhD
Department of Dermatology

Regulation of human pigmentation, photobiology and photocarcinogenesis, genetic susceptibility to melanoma; role of melanocortins and the melanocortin 1 receptor

Hassane Amlal, PhD
Internal Medicine
Nephrology

Regulation of acid-base transporters, glutamine metabolism, and inorganic phosphate in health and disease

Mark Baccei, PhD
Department of Anesthesiology

Characterization of the short- and long-term consequences of tissue injury during early life for the function of developing synaptic networks in the superficial dorsal horn of the spinal cord

George Deepe, MD
Department of Internal Medicine
Division of Infectious Diseases

Cellular immunology of fungal infections; characterization of the protective T-cell epitopes of H. capsulatum antigens and analysis of the functional activity of antigen-reactive T-cells 

Senad Divanovic, PhD
Cincinnati Children's
Division of Immunobiology

Our research program focuses on the role of immune response in inflammation and metabolism. Our expertise in pathways that regulate innate immunity — developed through the pursuit of studies ranging from reductive analysis of TLR ligand signaling to the role of IL-17 axis in experimental models of obesity and infection — have spearheaded the projects aimed at defining the role of the immune mediators in the development and progression of obesity, obesity-associated sequelae and infection / inflammation driven preterm birth. 

David Hui, PhD
Department of Pathology and Laboratory Medicine

Lipid Metabolism, Atherosclerosis, Diabetes, Obesity, Vascular Biology
Our research program focuses on three specific areas relating cholesterol metabolism with individual susceptibility for coronary heart disease. 

Jeffrey Molkentin, PhD
Cincinnati Children's
Division of Molecular Cardiovascular Biology

Molecular biology of heart and skeletal muscle disease

Laura Ramsey, PhD
Cincinnati Children's
Research in Patient Services

The Ramsey lab is interested in all aspects of pharmacogenetics, from basic research to implementation in patient care. Pharmacogenetics refers to the effect of a person’s genetic code on his/her response to a medication. Research has been done in this field for decades, but only recently has pharmacogenetic information been incorporated into clinical care. There are now guidelines for dosing of more than 30 drugs based on genetic information, provided by the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC). Many of the genes involved in response to medication alter the pharmacokinetics of the drug (the speed at which it’s absorbed, distributed, metabolized or eliminated).

Jack Rubinstein, MD
Department of Internal Medicine
Division of Cardiology

Advanced Echocardiographic Imaging, Myocardial Energy Utilization 

Sakthivel Sadayappan, PhD, MBA
Department of Internal Medicine
Division of Cardiology

The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. The sarcomere is the functional unit of striated muscle to generate contractility.

Michael Tranter, PhD
Department of Internal Medicine 
Division of Cardiology

The long-term goals of my research are to increase our understanding of the molecular mechanisms of cardiovascular disease. Within this realm, the ongoing work in the laboratory is broadly centered around post-transcriptional gene regulation in the setting of (1) pathological left ventricular hypertrophy and fibrosis, and (2) the mechanisms of cardioprotection against ischemia/reperfusion injury.

Patrick Tso, PhD
Department of Pathology and Laboratory Medicine

One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine.  The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology.

Jun-Ming Zhang, MD
Department of Anesthesiology

Physiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain.  Specifically, we are interested in whether extended nerve block provides additional benefit for patients with traumatic injury in lowing the risk of chronic pain; and how to improve efficacy of epidural steroids for managing low back pain.