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Photo of  Jed A. Hartings, PhD

Jed A. Hartings, PhD

Professor

Vice Chair of Research

Neurosurgery | College of Medicine

Education/Credentials
  • Doctoral Degree: University of Pittsburgh School of Medicine (Neuroscience)
  • Undergraduate: University of Notre Dame (Biological Sciences)
Contact Information
Research Interests

Areas of expertise - pathophysiology and treatment of traumatic brain injury and stroke, with emphasis on spreading depression, seizures, and neuromonitoring

Peer Reviewed Publications

Claassen, Jan; Akbari, Yama; Alexander, Sheila; Bader, Mary Kay; Bell, Kathleen; Bleck, Thomas P; Boly, Melanie; Brown, Jeremy; Chou, Sherry H-Y; Diringer, Michael N; Edlow, Brian L; Foreman, Brandon; Giacino, Joseph T; Gosseries, Olivia; Green, Theresa; Greer, David M; Hanley, Daniel F; Hartings, Jed A; Helbok, Raimund; Hemphill, J Claude; Hinson, H E; Hirsch, Karen; Human, Theresa; James, Michael L; Ko, Nerissa; Kondziella, Daniel; Livesay, Sarah; Madden, Lori K; Mainali, Shraddha; Mayer, Stephan A; McCredie, Victoria; McNett, Molly M; Meyfroidt, Geert; Monti, Martin M; Muehlschlegel, Susanne; Murthy, Santosh; Nyquist, Paul; Olson, DaiWai M; Provencio, J Javier; Rosenthal, Eric; Sampaio Silva, Gisele; Sarasso, Simone; Schiff, Nicholas D; Sharshar, Tarek; Shutter, Lori; Stevens, Robert D; Vespa, Paul; Videtta, Walter; Wagner, Amy; Ziai, Wendy; Whyte, John; Zink, Elizabeth; Suarez, Jose I 2021. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical care, 35 Suppl 1, 4-23

Foreman, Brandon; Lee, Hyunjo; Mizrahi, Moshe A; Hartings, Jed A; Ngwenya, Laura B; Privitera, Michael; Tortella, Frank C; Zhang, Nanhua; Kramer, Joel H 2021. Seizures and Cognitive Outcome After Traumatic Brain Injury: A Post Hoc Analysis. Neurocritical care, ,

Hartings, Jed A; Carroll, Christopher P; Lee, Gregory 2021. Spreading Diffusion-Restriction Events in the Gyrencephalic Brain After Subarachnoid Hemorrhage Revealed by Continuous Magnetic Resonance Imaging. Neurocritical care, ,

Jewell, Sharon; Hobson, Stephen; Brewer, Grant; Rogers, Michelle; Hartings, Jed A; Foreman, Brandon; Lavrador, José-Pedro; Sole, Michael; Pahl, Clemens; Boutelle, Martyn G; Strong, Anthony J 2021. Development and Evaluation of a Method for Automated Detection of Spreading Depolarizations in the Injured Human Brain. Neurocritical care, 35 Suppl 2, 160-175

Barhorst, Kinsey A; Alfawares, Yara; McGuire, Jennifer L; Danzer, Steve C; Hartings, Jed A; Ngwenya, Laura B 2020. Remote and Persistent Alterations in Glutamate Receptor Subunit Composition Induced by Spreading Depolarizations in Rat Brain. Cellular and molecular neurobiology, ,

Hartings, Jed A; Andaluz, Norberto; Bullock, M Ross; Hinzman, Jason M; Mathern, Bruce; Pahl, Clemens; Puccio, Ava; Shutter, Lori A; Strong, Anthony J; Vagal, Achala; Wilson, J Adam; Dreier, Jens P; Ngwenya, Laura B; Foreman, Brandon; Pahren, Laura; Lingsma, Hester; Okonkwo, David O 2020. Prognostic Value of Spreading Depolarizations in Patients With Severe Traumatic Brain Injury. JAMA neurology, 77 4, 489-499

Helbok, Raimund; Hartings, Jed A; Schiefecker, Alois; Balança, Baptiste; Jewel, Sharon; Foreman, Brandon; Ercole, Ari; Balu, Ramani; Ayata, Cenk; Ngwenya, Laura; Rosenthal, Eric; Boutelle, Martyn G; Farkas, Eszter; Dreier, Jens P; Fabricius, Martin; Shuttleworth, C William; Carlson, Andrew 2020. What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient? Neurocritical care, 32 1, 306-310

Provencio, J Javier; Hemphill, J Claude; Claassen, Jan; Edlow, Brian L; Helbok, Raimund; Vespa, Paul M; Diringer, Michael N; Polizzotto, Len; Shutter, Lori; Suarez, Jose I; Stevens, Robert D; Hanley, Daniel F; Akbari, Yama; Bleck, Thomas P; Boly, Melanie; Foreman, Brandon; Giacino, Joseph T; Hartings, Jed A; Human, Theresa; Kondziella, Daniel; Ling, Geoffrey S F; Mayer, Stephan A; McNett, Molly; Menon, David K; Meyfroidt, Geert; Monti, Martin M; Park, Soojin; Pouratian, Nader; Puybasset, Louis; Rohaut, Benjamin; Rosenthal, Eric S; Schiff, Nicholas D; Sharshar, Tarek; Wagner, Amy; Whyte, John; Olson, DaiWai M 2020. The Curing Coma Campaign: Framing Initial Scientific Challenges-Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting. Neurocritical care, 33 1, 1-12

Shuttleworth, C William; Andrew, R David; Akbari, Yama; Ayata, Cenk; Balu, Ramani; Brennan, K C; Boutelle, Martyn; Carlson, Andrew P; Dreier, Jens P; Fabricius, Martin; Farkas, Eszter; Foreman, Brandon; Helbok, Raimund; Henninger, Nils; Jewell, Sharon L; Jones, Stephen C; Kirov, Sergei A; Lindquist, Britta E; Maciel, Carolina B; Okonkwo, David; Reinhart, Katelyn M; Robertson, R Meldrum; Rosenthal, Eric S; Watanabe, Tomas; Hartings, Jed A 2020. Which Spreading Depolarizations Are Deleterious To Brain Tissue? Neurocritical care, 32 1, 317-322

Dreier, Jens P; Major, Sebastian; Lemale, Coline L; Kola, Vasilis; Reiffurth, Clemens; Schoknecht, Karl; Hecht, Nils; Hartings, Jed A; Woitzik, Johannes 2019. Correlates of Spreading Depolarization, Spreading Depression, and Negative Ultraslow Potential in Epidural Versus Subdural Electrocorticography. Frontiers in neuroscience, 13 , 373

Eriksen, Nina; Pakkenberg, Bente; Rostrup, Egill; Okonkwo, David O; Mathern, Bruce; Shutter, Lori A; Strong, Anthony J; Woitzik, Johannes; Pahl, Clemens; Dreier, Jens P; Martus, Peter; Lauritzen, Martin J; Fabricius, Martin; Hartings, Jed A 2019. Neurostereologic Lesion Volumes and Spreading Depolarizations in Severe Traumatic Brain Injury Patients: A Pilot Study. Neurocritical care, 30 3, 557-568

Eriksen, Nina; Rostrup, Egill; Fabricius, Martin; Scheel, Michael; Major, Sebastian; Winkler, Maren K L; Bohner, Georg; Santos, Edgar; Sakowitz, Oliver W; Kola, Vasilis; Reiffurth, Clemens; Hartings, Jed A; Vajkoczy, Peter; Woitzik, Johannes; Martus, Peter; Lauritzen, Martin; Pakkenberg, Bente; Dreier, Jens P 2019. Early focal brain injury after subarachnoid hemorrhage correlates with spreading depolarizations. Neurology, 92 4, e326-e341

Hartings, Jed A 2019. How slow can you go? Nature materials, 18 3, 194-196

Lee, Hyunjo; Mizrahi, Moshe A; Hartings, Jed A; Sharma, Sameer; Pahren, Laura; Ngwenya, Laura B; Moseley, Brian D; Privitera, Michael; Tortella, Frank C; Foreman, Brandon 2019. Continuous Electroencephalography After Moderate to Severe Traumatic Brain Injury. Critical care medicine, 47 4, 574-582

Santos, Edgar; Olivares-Rivera, Arturo; Major, Sebastian; Sánchez-Porras, Renán; Uhlmann, Lorenz; Kunzmann, Kevin; Zerelles, Roland; Kentar, Modar; Kola, Vasilis; Aguilera, Adrian Hernández; Herrera, Mildred Gutierrez; Lemale, Coline L; Woitzik, Johannes; Hartings, Jed A; Sakowitz, Oliver W; Unterberg, Andreas W; Dreier, Jens P 2019. Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study. Critical care (London, England), 23 1, 427

Carlson, Andrew P; Shuttleworth, C William; Major, Sebastian; Lemale, Coline L; Dreier, Jens P; Hartings, Jed A 2018. Terminal spreading depolarizations causing electrocortical silencing prior to clinical brain death: case report. Journal of neurosurgery, 131 6, 1773-1779

Dreier, Jens P; Major, Sebastian; Foreman, Brandon; Winkler, Maren K L; Kang, Eun-Jeung; Milakara, Denny; Lemale, Coline L; DiNapoli, Vince; Hinzman, Jason M; Woitzik, Johannes; Andaluz, Norberto; Carlson, Andrew; Hartings, Jed A 2018. Terminal spreading depolarization and electrical silence in death of human cerebral cortex. Annals of neurology, 83 2, 295-310

Foreman, Brandon; Ngwenya, Laura B; Stoddard, Erica; Hinzman, Jason M; Andaluz, Norberto; Hartings, Jed A 2018. Safety and Reliability of Bedside, Single Burr Hole Technique for Intracranial Multimodality Monitoring in Severe Traumatic Brain Injury. Neurocritical care, 29 3, 469-480

Hartings, Jed A; Ngwenya, Laura B; Carroll, Christopher P; Foreman, Brandon 2018. Letter to the Editor. Ketamine sedation for the suppression of spreading depolarizations. Journal of neurosurgery, , 1-2

Hartings, Jed A; Ngwenya, Laura B; Watanabe, Tomas; Foreman, Brandon 2018. Commentary: Detecting Cortical Spreading Depolarization with Full Band Scalp Electroencephalography: An Illusion? Frontiers in systems neuroscience, 12 , 19

Lückl, Janos; Lemale, Coline L; Kola, Vasilis; Horst, Viktor; Khojasteh, Uldus; Oliveira-Ferreira, Ana I; Major, Sebastian; Winkler, Maren K L; Kang, Eun-Jeung; Schoknecht, Karl; Martus, Peter; Hartings, Jed A; Woitzik, Johannes; Dreier, Jens P 2018. The negative ultraslow potential, electrophysiological correlate of infarction in the human cortex. Brain : a journal of neurology, 141 6, 1734-1752

Schinke, Christian; Horst, Viktor; Schlemm, Ludwig; Wawra, Matthias; Scheel, Michael; Hartings, Jed A; Dreier, Jens P 2018. A case report of delayed cortical infarction adjacent to sulcal clots after traumatic subarachnoid hemorrhage in the absence of proximal vasospasm. BMC neurology, 18 1, 210

Cnossen, Maryse C; Huijben, Jilske A; van der Jagt, Mathieu; Volovici, Victor; van Essen, Thomas; Polinder, Suzanne; Nelson, David; Ercole, Ari; Stocchetti, Nino; Citerio, Giuseppe; Peul, Wilco C; Maas, Andrew I R; Menon, David; Steyerberg, Ewout W; Lingsma, Hester F 2017. Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study. Critical care (London, England), 21 1, 233

Hartings JA 2017. Spreading depolarization monitoring in neurocritical care of acute brain injury Current Opinion in Critical Care, 23 2, 94

Hartings, Jed A 2017. Spreading depolarization monitoring in neurocritical care of acute brain injury. Current opinion in critical care, 23 2, 94-102

Hartings, Jed A; Dreier, Jens P 2017. Real-time detection of lesion development in acute brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37 5, 1550-1552

Hartings, Jed A; York, Jonathan; Carroll, Christopher P; Hinzman, Jason M; Mahoney, Eric; Krueger, Bryan; Winkler, Maren K L; Major, Sebastian; Horst, Viktor; Jahnke, Paul; Woitzik, Johannes; Kola, Vasilis; Du, Yifeng; Hagen, Matthew; Jiang, Jianxiong; Dreier, Jens P 2017. Subarachnoid blood acutely induces spreading depolarizations and early cortical infarction. Brain : a journal of neurology, 140 10, 2673-2690

Maas, Andrew I R; Menon, David K; Adelson, P David; Andelic, Nada; Bell, Michael J; Belli, Antonio; Bragge, Peter; Brazinova, Alexandra; Büki, András; Chesnut, Randall M; Citerio, Giuseppe; Coburn, Mark; Cooper, D Jamie; Crowder, A Tamara; Czeiter, Endre; Czosnyka, Marek; Diaz-Arrastia, Ramon; Dreier, Jens P; Duhaime, Ann-Christine; Ercole, Ari; van Essen, Thomas A; Feigin, Valery L; Gao, Guoyi; Giacino, Joseph; Gonzalez-Lara, Laura E; Gruen, Russell L; Gupta, Deepak; Hartings, Jed A; Hill, Sean; Jiang, Ji-Yao; Ketharanathan, Naomi; Kompanje, Erwin J O; Lanyon, Linda; Laureys, Steven; Lecky, Fiona; Levin, Harvey; Lingsma, Hester F; Maegele, Marc; Majdan, Marek; Manley, Geoffrey; Marsteller, Jill; Mascia, Luciana; McFadyen, Charles; Mondello, Stefania; Newcombe, Virginia; Palotie, Aarno; Parizel, Paul M; Peul, Wilco; Piercy, James; Polinder, Suzanne; Puybasset, Louis; Rasmussen, Todd E; Rossaint, Rolf; Smielewski, Peter; Söderberg, Jeannette; Stanworth, Simon J; Stein, Murray B; von Steinbüchel, Nicole; Stewart, William; Steyerberg, Ewout W; Stocchetti, Nino; Synnot, Anneliese; Te Ao, Braden; Tenovuo, Olli; Theadom, Alice; Tibboel, Dick; Videtta, Walter; Wang, Kevin K W; Williams, W Huw; Wilson, Lindsay; Yaffe, Kristine 2017. Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research. The Lancet. Neurology, 16 12, 987-1048

Milakara, Denny; Grozea, Cristian; Dahlem, Markus; Major, Sebastian; Winkler, Maren K L; Lückl, Janos; Scheel, Michael; Kola, Vasilis; Schoknecht, Karl; Lublinsky, Svetlana; Friedman, Alon; Martus, Peter; Hartings, Jed A; Woitzik, Johannes; Dreier, Jens P 2017. Simulation of spreading depolarization trajectories in cerebral cortex: Correlation of velocity and susceptibility in patients with aneurysmal subarachnoid hemorrhage. NeuroImage. Clinical, 16 , 524-538

Pinczolits A, Zdunczyk A, Dengler NF, Hecht N, Kowoll CM, Dohmen C, Graf R, Winkler MK, Major S, Hartings JA, Dreier JP, Vajkoczy P, Woitzik J. 2017. Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke Journal of Cerebral Blood Flow and Metabolism , 37 5, 1896

Pinczolits, Alexandra; Zdunczyk, Anna; Dengler, Nora F; Hecht, Nils; Kowoll, Christina M; Dohmen, Christian; Graf, Rudolf; Winkler, Maren Kl; Major, Sebastian; Hartings, Jed A; Dreier, Jens P; Vajkoczy, Peter; Woitzik, Johannes 2017. Standard-sampling microdialysis and spreading depolarizations in patients with malignant hemispheric stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37 5, 1896-1905

5. Wu Z, Li C, Hartings JA, Narayan R, Ahn C 2016. Polysilicon thin film developed on flexible polyimide for biomedical applications . IEEE Journal of Microelectromechanical Systems , 25 4, 585

Bogdanov, Volodymyr B; Middleton, Natalie A; Theriot, Jeremy J; Parker, Patrick D; Abdullah, Osama M; Ju, Y Sungtaek; Hartings, Jed A; Brennan, K C 2016. Susceptibility of Primary Sensory Cortex to Spreading Depolarizations. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 17, 4733-43

Dreier, Jens P; Fabricius, Martin; Ayata, Cenk; Sakowitz, Oliver W; William Shuttleworth, C; Dohmen, Christian; Graf, Rudolf; Vajkoczy, Peter; Helbok, Raimund; Suzuki, Michiyasu; Schiefecker, Alois J; Major, Sebastian; Winkler, Maren Kl; Kang, Eun-Jeung; Milakara, Denny; Oliveira-Ferreira, Ana I; Reiffurth, Clemens; Revankar, Gajanan S; Sugimoto, Kazutaka; Dengler, Nora F; Hecht, Nils; Foreman, Brandon; Feyen, Bart; Kondziella, Daniel; Friberg, Christian K; Piilgaard, Henning; Rosenthal, Eric S; Westover, M Brandon; Maslarova, Anna; Santos, Edgar; Hertle, Daniel; Sánchez-Porras, Renán; Jewell, Sharon L; Balança, Baptiste; Platz, Johannes; Hinzman, Jason M; Lückl, Janos; Schoknecht, Karl; Schöll, Michael; Drenckhahn, Christoph; Feuerstein, Delphine; Eriksen, Nina; Horst, Viktor; Bretz, Julia S; Jahnke, Paul; Scheel, Michael; Bohner, Georg; Rostrup, Egill; Pakkenberg, Bente; Heinemann, Uwe; Claassen, Jan; Carlson, Andrew P; Kowoll, Christina M; Lublinsky, Svetlana; Chassidim, Yoash; Shelef, Ilan; Friedman, Alon; Brinker, Gerrit; Reiner, Michael; Kirov, Sergei A; Andrew, R David; Farkas, Eszter; Güresir, Erdem; Vatter, Hartmut; Chung, Lee S; Brennan, K C; Lieutaud, Thomas; Marinesco, Stephane; Maas, Andrew Ir; Sahuquillo, Juan; Dahlem, Markus A; Richter, Frank; Herreras, Oscar; Boutelle, Martyn G; Okonkwo, David O; Bullock, M Ross; Witte, Otto W; Martus, Peter; van den Maagdenberg, Arn Mjm; Ferrari, Michel D; Dijkhuizen, Rick M; Shutter, Lori A; Andaluz, Norberto; Schulte, André P; MacVicar, Brian; Watanabe, Tomas; Woitzik, Johannes; Lauritzen, Martin; Strong, Anthony J; Hartings, Jed A 2016. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Drenckhahn, Christoph; Windler, Claudia; Major, Sebastian; Kang, Eun-Jeung; Scheel, Michael; Vajkoczy, Peter; Hartings, Jed A; Woitzik, Johannes; Dreier, Jens P 2016. Complications in Aneurysmal Subarachnoid Hemorrhage Patients With and Without Subdural Electrode Strip for Electrocorticography. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 33 3, 250-9

Hartings, Jed A; Li, Chunyan; Hinzman, Jason M; Shuttleworth, C William; Ernst, Griffin L; Dreier, Jens P; Wilson, J Adam; Andaluz, Norberto; Foreman, Brandon; Carlson, Andrew P 2016. Direct current electrocorticography for clinical neuromonitoring of spreading depolarizations. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Hartings, Jed A; Shuttleworth, C William; Kirov, Sergei A; Ayata, Cenk; Hinzman, Jason M; Foreman, Brandon; Andrew, R David; Boutelle, Martyn G; Brennan, K C; Carlson, Andrew P; Dahlem, Markus A; Drenckhahn, Christoph; Dohmen, Christian; Fabricius, Martin; Farkas, Eszter; Feuerstein, Delphine; Graf, Rudolf; Helbok, Raimund; Lauritzen, Martin; Major, Sebastian; Oliveira-Ferreira, Ana I; Richter, Frank; Rosenthal, Eric S; Sakowitz, Oliver W; Sánchez-Porras, Renán; Santos, Edgar; Schöll, Michael; Strong, Anthony J; Urbach, Anja; Westover, M Brandon; Winkler, Maren Kl; Witte, Otto W; Woitzik, Johannes; Dreier, Jens P 2016. The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Li, Chunyan; Narayan, Raj K; Wang, Ping; Hartings, Jed A 2016. Regional temperature and quantitative cerebral blood flow responses to cortical spreading depolarization in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Li, Chunyan; Narayan, Raj K; Wu, Pei-Ming; Rajan, Neena; Wu, Zhizhen; Mehan, Neal; Golanov, Eugene V; Ahn, Chong H; Hartings, Jed A 2016. Evaluation of microelectrode materials for direct-current electrocorticography. Journal of neural engineering, 13 1, 016008

Li, Chunyan; Wu, Zhizhen; Limnuson, Kanokwan; Cheyuo, Cletus; Wang, Ping; Ahn, Chong H; Narayan, Raj K; Hartings, Jed A 2016. Development and application of a microfabricated multimodal neural catheter for neuroscience. Biomedical microdevices, 18 1, 8

Toth, Peter; Szarka, Nikolett; Farkas, Eszter; Ezer, Erzsebet; Czeiter, Endre; Amrein, Krisztina; Ungvari, Zoltan; Hartings, Jed A; Buki, Andras; Koller, Akos 2016. Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications. American journal of physiology. Heart and circulatory physiology, 311 5, H1118-H1131

Winkler, Maren Kl; Dengler, Nora; Hecht, Nils; Hartings, Jed A; Kang, Eun J; Major, Sebastian; Martus, Peter; Vajkoczy, Peter; Woitzik, Johannes; Dreier, Jens P 2016. Oxygen availability and spreading depolarizations provide complementary prognostic information in neuromonitoring of aneurysmal subarachnoid hemorrhage patients. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Wu Z, Li C, Hartings JA, Narayan RK, Ahn C 2016. Polysilicon based flexible temperature sensor for high resolution brain temperature monitoring . Conf Proc IEEE Eng Med Biol Soc , , 500

Hinzman, Jason M; DiNapoli, Vince A; Mahoney, Eric J; Gerhardt, Greg A; Hartings, Jed A 2015. Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions. Experimental neurology, 267 , 243-53

Hinzman, Jason M; Gibson, Justin L; Tackla, Ryan D; Costello, Mark S; Burmeister, Jason J; Quintero, Jorge E; Gerhardt, Greg A; Hartings, Jed A 2015. Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays. Biosensors & bioelectronics, 74 , 512-517

Hinzman, Jason; Wilson, J Adam; Mazzeo, Anna Teresa; Bullock, Ross; Hartings, Jed A 2015. Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients. Journal of neurotrauma, ,

Li, Chunyan; Limnuson, Kanokwan; Wu, Zhizhen; Amin, Aseer; Narayan, Anjali; Golanov, Eugene V; Ahn, Chong H; Hartings, Jed A; Narayan, Raj K 2015. Single probe for real-time simultaneous monitoring of neurochemistry and direct-current electrocorticography. Biosensors & bioelectronics, 77 , 62-68

Li, Chunyan; Wu, Pei-Ming; Wu, Zhizhen; Limnuson, Kanokwan; Mehan, Neal; Mozayan, Cameron; Golanov, Eugene V; Ahn, Chong H; Hartings, Jed A; Narayan, Raj K 2015. Highly accurate thermal flow microsensor for continuous and quantitative measurement of cerebral blood flow. Biomedical microdevices, 17 5, 9992

Maas, Andrew I R; Menon, David K; Steyerberg, Ewout W; Citerio, Giuseppe; Lecky, Fiona; Manley, Geoffrey T; Hill, Sean; Legrand, Valerie; Sorgner, Annina 2015. Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study. Neurosurgery, 76 1, 67-80

Tackla, Ryan; Hinzman, Jason M; Foreman, Brandon; Magner, Mark; Andaluz, Norberto; Hartings, Jed A 2015. Assessment of Cerebrovascular Autoregulation Using Regional Cerebral Blood Flow in Surgically Managed Brain Trauma Patients. Neurocritical care, ,

Jeffcote, Toby; Hinzman, Jason M; Jewell, Sharon L; Learney, Robert M; Pahl, Clemens; Tolias, Christos; Walsh, Daniel C; Hocker, Sara; Zakrzewska, Agnieszka; Fabricius, Martin E; Strong, Anthony J; Hartings, Jed A; Boutelle, Martyn G 2014. Detection of spreading depolarization with intraparenchymal electrodes in the injured human brain. Neurocritical care, 20 1, 21-31

Dreier, Jens P; Drenckhahn, Christoph; Woitzik, Johannes; Major, Sebastian; Offenhauser, Nikolas; Weber-Carstens, Steffen; Wolf, Stefan; Strong, Anthony J; Vajkoczy, Peter; Hartings, Jed A 2013. Spreading Ischemia After Aneurysmal Subarachnoid Hemorrhage. Acta neurochirurgica. Supplement, 115 , 125-129

Hartings, Jed A; Vidgeon, Steven; Strong, Anthony J; Zacko, Chris; Vagal, Achala; Andaluz, Norberto; Ridder, Thomas; Stanger, Richard; Fabricius, Martin; Mathern, Bruce; Pahl, Clemens; Tolias, Christos M; Bullock, M Ross 2013. Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers. Journal of neurosurgery, ,

Hartings, Jed A; Wilson, J Adam; Look, Andrew C; Vagal, Achala; Shutter, Lori A; Dreier, Jens P; Ringer, Andrew; Zuccarello, Mario 2013. Full-band electrocorticography of spreading depolarizations in patients with aneurysmal subarachnoid hemorrhage. Acta neurochirurgica. Supplement, 115 , 131-41

Serrone, Joseph C; Wash, Erin M; Hartings, Jed A; Andaluz, Norberto; Zuccarello, Mario 2013. Venous Thromboembolism in Subarachnoid Hemorrhage. World neurosurgery, ,

Wilson, J Adam; Shutter, Lori A; Hartings, Jed A 2013. COSBID-M3: A Platform for Multimodal Monitoring, Data Collection, and Research in Neurocritical Care. Acta neurochirurgica. Supplement, 115 , 67-74

Dreier, Jens P; Major, Sebastian; Pannek, Heinz-Wolfgang; Woitzik, Johannes; Scheel, Michael; Wiesenthal, Dirk; Martus, Peter; Winkler, Maren K L; Hartings, Jed A; Fabricius, Martin; Speckmann, Erwin-Josef; Gorji, Ali 2012. Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex. Brain : a journal of neurology, 135 Pt 1, 259-75

Drenckhahn, Christoph; Winkler, Maren K L; Major, Sebastian; Scheel, Michael; Kang, Eun-Jeung; Pinczolits, Alexandra; Grozea, Cristian; Hartings, Jed A; Woitzik, Johannes; Dreier, Jens P 2012. Correlates of spreading depolarization in human scalp electroencephalography. Brain : a journal of neurology, 135 Pt 3, 853-68

Hertle, Daniel N; Dreier, Jens P; Woitzik, Johannes; Hartings, Jed A; Bullock, Ross; Okonkwo, David O; Shutter, Lori A; Vidgeon, Steven; Strong, Anthony J; Kowoll, Christina; Dohmen, Christian; Diedler, Jennifer; Veltkamp, Roland; Bruckner, Thomas; Unterberg, Andreas W; Sakowitz, Oliver W 2012. Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury. Brain : a journal of neurology, 135 Pt 8, 2390-2398

Li, Chunyan; Wu, Pei-Ming; Hartings, Jed A; Wu, Zhizhen; Cheyuo, Cletus; Wang, Ping; Ledoux, David; Shutter, Lori A; Ramaswamy, Bharat Ram; Ahn, Chong H; Narayan, Raj K 2012. Micromachined lab-on-a-tube sensors for simultaneous brain temperature and cerebral blood flow measurements. Biomedical microdevices, ,

Li, Chunyan; Wu, Pei-Ming; Wu, Zhizhen; Ahn, Chong H; LeDoux, David; Shutter, Lori A; Hartings, Jed A; Narayan, Raj K 2012. Brain temperature measurement: A study of in vitro accuracy and stability of smart catheter temperature sensors. Biomedical microdevices, 14 1, 109-18

Li, Chunyan; Wu, Zhizhen; Hartings, Jed A; Rajan, Neena; Chahine, Nadeen; Cheyuo, Cletus; Wang, Ping; Wu, Pei-Ming; Golanov, Eugene V; Ahn, Chong H; Narayan, Raj K 2012. Brain-friendly amperometric enzyme biosensor based on encapsulated oxygen generating biomaterial. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2012 , 6003-6

Fioravanti, Beatriz; Kasasbeh, Aimen; Edelmayer, Rebecca; Skinner, David P; Hartings, Jed A; Burklund, Ryan D; De Felice, Milena; French, Edward D; Dussor, Greg O; Dodick, David W; Porreca, Frank; Vanderah, Todd W 2011. Evaluation of cutaneous allodynia following induction of cortical spreading depression in freely moving rats. Cephalalgia : an international journal of headache, 31 10, 1090-100

Hartings, Jed A; Bullock, M Ross; Okonkwo, David O; Murray, Lilian S; Murray, Gordon D; Fabricius, Martin; Maas, Andrew Ir; Woitzik, Johannes; Sakowitz, Oliver; Mathern, Bruce; Roozenbeek, Bob; Lingsma, Hester; Dreier, Jens P; Puccio, Ava M; Shutter, Lori A; Pahl, Clemens; Strong, Anthony J 2011. Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study. Lancet neurology, 10 12, 1058-64

Hartings, Jed A; Watanabe, Tomas; Bullock, M Ross; Okonkwo, David O; Fabricius, Martin; Woitzik, Johannes; Dreier, Jens P; Puccio, Ava; Shutter, Lori A; Pahl, Clemens; Strong, Anthony J 2011. Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma. Brain : a journal of neurology, 134 Pt 5, 1529-40

Lauritzen, Martin; Dreier, Jens Peter; Fabricius, Martin; Hartings, Jed A; Graf, Rudolf; Strong, Anthony John 2011. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 31 1, 17-35

Lu, Xi-Chun May; Hartings, Jed A; Si, Yuanzheng; Balbir, Alexander; Cao, Ying; Tortella, Frank C 2011. Electrocortical pathology in a rat model of penetrating ballistic-like brain injury. Journal of neurotrauma, 28 1, 71-83

Eriksen, N; Rostrup, E; Andersen, K; Lauritzen, M J; Fabricius, M; Larsen, V A; Dreier, J P; Strong, A J; Hartings, J A; Pakkenberg, B 2010. Application of stereological estimates in patients with severe head injuries using CT and MR scanning images. The British journal of radiology, 83 988, 307-17

Oliveira-Ferreira, Ana I; Milakara, Denny; Alam, Mesbah; Jorks, Devi; Major, Sebastian; Hartings, Jed A; Lückl, Janos; Martus, Peter; Graf, Rudolf; Dohmen, Christian; Bohner, Georg; Woitzik, Johannes; Dreier, Jens P 2010. Experimental and preliminary clinical evidence of an ischemic zone with prolonged negative DC shifts surrounded by a normally perfused tissue belt with persistent electrocorticographic depression. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 30 8, 1504-19

Dreier, Jens P; Major, Sebastian; Manning, Andrew; Woitzik, Johannes; Drenckhahn, Chistoph; Steinbrink, Jens; Tolias, Christos; Oliveira-Ferreira, Ana I; Fabricius, Martin; Hartings, Jed A; Vajkoczy, Peter; Lauritzen, Martin; Dirnagl, Ulrich; Bohner, Georg; Strong, Anthony J 2009. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain : a journal of neurology, 132 Pt 7, 1866-81

Hartings, Jed A; Strong, Anthony J; Fabricius, Martin; Manning, Andrew; Bhatia, Robin; Dreier, Jens P; Mazzeo, Anna Teresa; Tortella, Frank C; Bullock, M Ross 2009. Spreading depolarizations and late secondary insults after traumatic brain injury. Journal of neurotrauma, 26 11, 1857-66

Hartings, Jed A; Watanabe, Tomas; Dreier, Jens P; Major, Sebastian; Vendelbo, Leif; Fabricius, Martin 2009. Recovery of slow potentials in AC-coupled electrocorticography: application to spreading depolarizations in rat and human cerebral cortex. Journal of neurophysiology, 102 4, 2563-75

Lu, Xi-Chun M; Si, Yuanzheng; Williams, Anthony J; Hartings, Jed A; Gryder, Divina; Tortella, Frank C 2009. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29 12, 1924-32

Fabricius, Martin; Fuhr, Susanne; Willumsen, Lisette; Dreier, Jens P; Bhatia, Robin; Boutelle, Martyn G; Hartings, Jed A; Bullock, Ross; Strong, Anthony J; Lauritzen, Martin 2008. Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 119 9, 1973-84

Hartings, Jed A; Gugliotta, Marinella; Gilman, Charlotte; Strong, Anthony J; Tortella, Frank C; Bullock, M Ross 2008. Repetitive cortical spreading depolarizations in a case of severe brain trauma. Neurological research, 30 8, 876-82

Wei, Guo; Hartings, Jed A; Yang, Xiaofang; Tortella, Frank C; Lu, Xi-Chun M 2008. Extraluminal cooling of bilateral common carotid arteries as a method to achieve selective brain cooling for neuroprotection. Journal of neurotrauma, 25 5, 549-59

Williams, Anthony J; Tortella, Frank C; Gryder, Divina; Hartings, Jed A 2008. Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat. Neuroscience letters, 430 1, 7-12

Strong, Anthony J; Hartings, Jed A; Dreier, Jens P 2007. Cortical spreading depression: an adverse but treatable factor in intensive care? Current opinion in critical care, 13 2, 126-33

Dreier, Jens P; Woitzik, Johannes; Fabricius, Martin; Bhatia, Robin; Major, Sebastian; Drenckhahn, Chistoph; Lehmann, Thomas-Nicolas; Sarrafzadeh, Asita; Willumsen, Lisette; Hartings, Jed A; Sakowitz, Oliver W; Seemann, Jörg H; Thieme, Anja; Lauritzen, Martin; Strong, Anthony J 2006. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain : a journal of neurology, 129 Pt 12, 3224-37

Hartings, Jed A; Tortella, Frank C; Rolli, Michael L 2006. AC electrocorticographic correlates of peri-infarct depolarizations during transient focal ischemia and reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 26 5, 696-707

Williams, Anthony J; Bautista, Charisma C; Chen, Ren-Wu; Dave, Jitendra R; Lu, Xi-Chun M; Tortella, Frank C; Hartings, Jed A 2006. Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. The Journal of pharmacology and experimental therapeutics, 318 3, 947-55

Williams, Anthony J; Hartings, Jed A; Lu, Xi-Chun M; Rolli, Michael L; Tortella, Frank C 2006. Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration. Journal of neurotrauma, 23 12, 1828-46

Lu, X-C May; Williams, Anthony J; Wagstaff, John D; Tortella, Frank C; Hartings, Jed A 2005. Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations. Brain research, 1056 2, 200-8

Williams, Anthony J; Hartings, Jed A; Lu, X-C May; Rolli, Michael L; Dave, Jitendra R; Tortella, Frank C 2005. Characterization of a new rat model of penetrating ballistic brain injury. Journal of neurotrauma, 22 2, 313-31

Yao, C; Williams, A J; Hartings, J A; Lu, X-C M; Tortella, F C; Dave, J R 2005. Down-regulation of the sodium channel Na(v)1.1 alpha-subunit following focal ischemic brain injury in rats: in situ hybridization and immunohistochemical analysis. Life sciences, 77 10, 1116-29

Khatri, V; Hartings, J A; Simons, D J 2004. Adaptation in thalamic barreloid and cortical barrel neurons to periodic whisker deflections varying in frequency and velocity. Journal of neurophysiology, 92 6, 3244-54

Lu, X-C May; Williams, Anthony J; Yao, Changping; Berti, Rossana; Hartings, Jed A; Whipple, Rebecca; Vahey, Maryanne T; Polavarapu, Ratna G; Woller, Kimberly L; Tortella, Frank C; Dave, Jitendra R 2004. Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion. Journal of neuroscience research, 77 6, 843-57

Williams, A J; Tortella, F C; Lu, X M; Moreton, J E; Hartings, J A 2004. Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. The Journal of pharmacology and experimental therapeutics, 311 1, 220-7

Hartings, Jed A; Rolli, Michael L; Lu, X-C May; Tortella, Frank C 2003. Delayed secondary phase of peri-infarct depolarizations after focal cerebral ischemia: relation to infarct growth and neuroprotection. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 37, 11602-10

Hartings, Jed A; Temereanca, Simona; Simons, Daniel J 2003. Processing of periodic whisker deflections by neurons in the ventroposterior medial and thalamic reticular nuclei. Journal of neurophysiology, 90 5, 3087-94

Hartings, Jed A; Temereanca, Simona; Simons, Daniel J 2003. State-dependent processing of sensory stimuli by thalamic reticular neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 12, 5264-71

Hartings, Jed A; Williams, Anthony J; Tortella, Frank C 2003. Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia. Experimental neurology, 179 2, 139-49

Pinto, David J; Hartings, Jed A; Brumberg, Joshua C; Simons, Daniel J 2003. Cortical damping: analysis of thalamocortical response transformations in rodent barrel cortex. Cerebral cortex (New York, N.Y. : 1991), 13 1, 33-44

Williams, Anthony J; Lu, Xi-Chun M; Hartings, Jed A; Tortella, Frank C 2003. Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats. Fundamental & clinical pharmacology, 17 5, 581-93

Kelly, M K; Carvell, G E; Hartings, J A; Simons, D J 2001. Axonal conduction properties of antidromically identified neurons in rat barrel cortex. Somatosensory & motor research, 18 3, 202-10

Hartings, J A; Simons, D J 2000. Inhibition suppresses transmission of tonic vibrissa-evoked activity in the rat ventrobasal thalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience, 20 19, RC100

Hartings, J A; Temereanca, S; Simons, D J 2000. High responsiveness and direction sensitivity of neurons in the rat thalamic reticular nucleus to vibrissa deflections. Journal of neurophysiology, 83 5, 2791-801

Hartings, J A; Simons, D J 1998. Thalamic relay of afferent responses to 1- to 12-Hz whisker stimulation in the rat. Journal of neurophysiology, 80 2, 1016-9

Fraser, George; Hartings, Jed A; Simons, Daniel J . Adaptation of trigeminal ganglion cells to periodic whisker deflections. Somatosensory & motor research, 23 3-4, 111-8