Richard L. Thompson, PhD

Sawtell, Nancy M; Thompson, Richard L 2016. De Novo Herpes Simplex Virus VP16 Expression Gates a Dynamic Programmatic Transition and Sets the Latent/Lytic Balance during Acute Infection in Trigeminal Ganglia. PLoS pathogens, 12 9, e1005877

Sawtell, Nancy M; Thompson, Richard L 2016. Herpes simplex virus and the lexicon of latency and reactivation: a call for defining terms and building an integrated collective framework. F1000Research, 5 ,

Sawtell, Nancy M; Thompson, Richard L 2014. Herpes simplex virus mutant generation and dual-detection methods for gaining insight into latent/lytic cycles in vivo. Methods in molecular biology (Clifton, N.J.), 1144 , 129-47

Thompson, Richard L; Williams, Robert W; Kotb, Malak; Sawtell, Nancy M 2014. A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. PloS one, 9 3, e92342

Sawtell, Nancy M; Triezenberg, Steven J; Thompson, Richard L 2011. VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo. Journal of neurovirology, 17 6, 546-51

Thompson, Richard L; Sawtell, Nancy M 2011. The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections. Journal of neurovirology, 17 6, 552-8

Thompson, Richard L; Sawtell, Nancy M 2010. Therapeutic implications of new insights into the critical role of VP16 in initiating the earliest stages of HSV reactivation from latency. Future medicinal chemistry, 2 7, 1099-105

Thompson, Richard L; Preston, Chris M; Sawtell, Nancy M 2009. De novo synthesis of VP16 coordinates the exit from HSV latency in vivo. PLoS pathogens, 5 3, e1000352

Sawtell, N M; Thompson, R L; Haas, R L 2006. Herpes simplex virus DNA synthesis is not a decisive regulatory event in the initiation of lytic viral protein expression in neurons in vivo during primary infection or reactivation from latency. Journal of virology, 80 1, 38-50

Thompson, R L; Sawtell, N M 2006. Evidence that the herpes simplex virus type 1 ICP0 protein does not initiate reactivation from latency in vivo. Journal of virology, 80 22, 10919-30

Sawtell, N M; Thompson, R L 2004. Comparison of herpes simplex virus reactivation in ganglia in vivo and in explants demonstrates quantitative and qualitative differences. Journal of virology, 78 14, 7784-94

Thompson, R L; Shieh, May T; Sawtell, N M 2003. Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo. Journal of virology, 77 22, 12319-30

Sawtell, N M; Thompson, R L; Stanberry, L R; Bernstein, D I 2001. Early intervention with high-dose acyclovir treatment during primary herpes simplex virus infection reduces latency and subsequent reactivation in the nervous system in vivo. The Journal of infectious diseases, 184 8, 964-71

Thompson, R L; Sawtell, N M 2001. Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. Journal of virology, 75 14, 6660-75

Thompson, R L; Sawtell, N M 2000. HSV latency-associated transcript and neuronal apoptosis. Science (New York, N.Y.), 289 5485, 1651

Thompson, R L; Sawtell, N M 2000. Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency. Journal of virology, 74 2, 965-74

Sawtell, N M; Poon, D K; Tansky, C S; Thompson, R L 1998. The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. Journal of virology, 72 7, 5343-50

Thompson, R L; Sawtell, N M 1997. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. Journal of virology, 71 7, 5432-40

Perng, G C; Chokephaibulkit, K; Thompson, R L; Sawtell, N M; Slanina, S M; Ghiasi, H; Nesburn, A B; Wechsler, S L 1996. The region of the herpes simplex virus type 1 LAT gene that is colinear with the ICP34.5 gene is not involved in spontaneous reactivation. Journal of virology, 70 1, 282-91

Perng, G C; Thompson, R L; Sawtell, N M; Taylor, W E; Slanina, S M; Ghiasi, H; Kaiwar, R; Nesburn, A B; Wechsler, S L 1995. An avirulent ICP34.5 deletion mutant of herpes simplex virus type 1 is capable of in vivo spontaneous reactivation. Journal of virology, 69 5, 3033-41

Bolovan, C A; Sawtell, N M; Thompson, R L 1994. ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures. Journal of virology, 68 1, 48-55

Pyles, R B; Thompson, R L 1994. Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system. Journal of virology, 68 8, 4963-72

Pyles, R B; Sawtell, N M; Thompson, R L 1992. Herpes simplex virus type 1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. Journal of virology, 66 11, 6706-13

Sawtell, N M; Thompson, R L 1992. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency. Journal of virology, 66 4, 2157-69

Sawtell, N M; Thompson, R L 1992. Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. Journal of virology, 66 4, 2150-6

Thompson, R L; Rogers, S K; Zerhusen, M A 1989. Herpes simplex virus neurovirulence and productive infection of neural cells is associated with a function which maps between 0.82 and 0.832 map units on the HSV genome. Virology, 172 2, 435-50

Thompson, R L; Devi-Rao, G V; Wagner, E K 1988. DNA sequence and RNA transcription through a site of recombination in a non-neurovirulent herpes simplex virus intertypic recombinant. Virus genes, 1 3, 275-86

Thompson, R L; Wagner, E K 1988. Partial rescue of herpes simplex virus neurovirulence with a 3.2 kb cloned DNA fragment. Virus genes, 1 3, 261-73

Cook, M L; Thompson, R L; Stevens, J G 1986. A herpes simplex virus mutant is temperature sensitive for reactivation from the latent state: evidence for selective restriction in neuronal cells. Virology, 155 1, 293-6

Draper, K G; Devi-Rao, G; Costa, R H; Blair, E D; Thompson, R L; Wagner, E K 1986. Characterization of the genes encoding herpes simplex virus type 1 and type 2 alkaline exonucleases and overlapping proteins. Journal of virology, 57 3, 1023-36

Thompson, R L; Cook, M L; Devi-Rao, G B; Wagner, E K; Stevens, J G 1986. Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS. Journal of virology, 58 1, 203-11

Thompson, R L; Nakashizuka, M; Stevens, J G 1986. Vaccine potential of a live avirulent herpes simplex virus. Microbial pathogenesis, 1 4, 409-16

Costa, R H; Draper, K G; Devi-Rao, G; Thompson, R L; Wagner, E K 1985. Virus-induced modification of the host cell is required for expression of the bacterial chloramphenicol acetyltransferase gene controlled by a late herpes simplex virus promoter (VP5). Journal of virology, 56 1, 19-30

Thompson, R L; Devi-Rao, G V; Stevens, J G; Wagner, E K 1985. Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment. Journal of virology, 55 2, 504-8

Thompson, R L; Stevens, J G 1983. Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent. Virology, 131 1, 171-9

Thompson, R L; Stevens, J G 1983. Replication at body temperature selects a neurovirulent herpes simplex virus type 2. Infection and immunity, 41 2, 855-7

Thompson, R L; Wagner, E K; Stevens, J G 1983. Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence. Virology, 131 1, 180-92