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Representative publications are listed below (*, Corresponding Author)
Complete list of our publications, please visit: Guo Chang Fan Publications (Pubmed)
Citations of our published work:  Guo Chang Fan Citations (Google Scholar)

  1. Fan GC, Singh RR. Vaccination with minigenes encoding VH-derived MHC class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus.  J. Exp. Med. 2002, 196 (6): 731-741.
  2. Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG. Small heat-shock protein Hsp20 phos-phorylation inhibits beta-agonist-induced cardiac apoptosis. Circ. Res. 2004, 94(11):1474-1482.
  3. Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, Jones WK, Chu G, Kranias EG. A novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005, 111 (14): 1792-1799.
  4. Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG.  Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ Res. 2006; 99(11):1233-1242.
  5. Fan GC*, Zhou X, Wang X, Song G, Qian J, Nicolaou P, Chen G, Ren X, and Kranias EG.  Hsp20 Interacting with Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity.  Circ. Res. 2008, 103:1270-1279.
  6. Ren XP, Wu J, Wang XH, Sartor MA, Qian J, Nicoloau P, Jones WK, Pritchard TJ, and Fan GC*.  MicroRNA-320 is involved in regulation of ischemia/reperfusion-induced cardiac injury by targeting Hsp20. Circulation. 2009, 119:2357-2366.
  7. Qian J, Ren X, Wang X, Zhang P, Jones K, Molkentin J, Fan GC*, and Kranias EG*. Blockade of Hsp20 phosphorylation reduces ischemia/reperfusion-induced autophagy and exaggerates cardiac injury. Circ. Res. 2009, 105:1223-1231.
  8. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, and Fan GC*.  Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and secretion of growth factors.  Stem Cells, 2009 27(12):3021-31.
  9. Wang XH, Zhang X, Ren X, Chen J, Liu H, Medvedvic M, Yang J, Hu Z and Fan GC*.  MicroRNA-494 Targeting both Pro-apoptotic and Anti-apoptotic Proteins Protects against Ischemia/Reperfusion-Induced Cardiac Injury. Circulation, 2010, 122:1308-1318.
  10. Qian J, Vafiadaki E, Florea SM, Singh VP, Lam CK, Wang Y, Yuan Q, Song W, Pritchard TJ, Cai W, Wang HS, Fan GC*, and Kranias EG*. The Small Heat Shock Protein 20 (Hsp20) Interacts with Protein Phosphatase-1 and Enhances Sarcoplasmic Reticulum Ca-Cycling. Circ. Res. 2011, 108(12):1429-38.
  11. Wang X, Zhu H, Zhang X, Liu Y, Chen J, Medvedovi M, Weiss M, Ren X, Fan GC*. Loss of MiR-144/451 Cluster Impairs Ischemic Preconditioning-Mediated Cardioprotection via Targeting Rac-1. Cardiovasc Res. 2012, 94:379-390.
  12. Fan GC. Hypoxic exosomes promote angiogenesis. Blood, 2014, 124:3669-70.
  13. Wang X, Gu H, Huang W, Qin D, Yang L, Peng J, Li Y, Wang Y, Peng T, Fan GC*. Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Diabetes. 2016, 65(10):3111-28.
  14. Yang L, Wang X, Li Y, Peng J, Huang W, Wang Y, Fan GC*. Overexpression of miR-223 tips the balance of pro-/anti-hypertrophic signaling cascades toward physiological cardiac hypertrophy. J Biol Chem. 2016; 291(30):15700-13. 
  15. Qin D, Wang X, Li Y, Yang L, Wang R, Peng J, Essandoh K, Mu X, Peng T, Han Q, Yu KJ, Fan GC*. MicroRNA-223-5p and -3p cooperatively suppress necroptosis in ischemic/reperfused hearts. J Biol Chem. 2016; 291(38):20247-59.
  16. Liu GS, Zhu H, Cai WF, Wang X, Jiang M, Essandoh K, Vafiadaki E, Haghighi K, Lam CK, Gardner G, Adly G, Nicolaou P, Sanoudou D, Liang Q, Rubinstein J, Fan GC*, Kranias EG*. Regulation of BECN1-mediated autophagy by HSPB6: insights from a human HSPB6-S10F mutant. Autophagy.2018, 14 (1):80-97.
  17. Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, Chen J, Gu H, Essandoh K, Mu X, McNamara RK, Peng T, Jegga AG, Liu T, Nakamura T, Huang K, Perez-Tilve D, Fan GC*. An Hsp20-FBXO4 axis regulates adipocyte function through modulating PPARγ ubiquitination. Cell Rep. 2018; 23 (12):3607-3620.
  18. Essandoh K, Deng S, Wang X, Jiang M, Mu X, Peng J, Li Y, Peng T, Rubinstein J, Wagner KW, Fan GC*. Tsg101-mediated endosomal recycling of IGF-1R is essential for exercise-induced physiological cardiac growth. FASEB J. 2019 Jun; 33(6):7451-7466.
  19. Li Y, Peng J, Deng S, Wang X, Essandoh K, Mu X, Peng T, Meng Z, Fan GC*. MiR-223 is essential for maintaining functional β-cell mass during diabetes through targeting unique bipartite Foxo1 and Sox6 pathways. J Biol Chem. 2019, 294(27):10438-10448.
  20. Essandoh K, Wang X, Huang W, Deng S, Mu X, Peng J, Li Y, Wang Y, Fan GC*. Tsg101 ameliorates endotoxin-induced cardiac dysfunction via enhancing Parkin-mediated mitophagy. J Biol Chem. 2019; 294(48):18057-18068.
  21. Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan J-L, Wang Y, Jegga A, Huang K, and Fan GC*. Tsg101 positively regulate P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.  Redox Biology. 2020; 32:101453.
  22. Mu X, Wang P, Wang X, Li Y, Zhao H, Li Q, Essandoh K, Deng S, Peng T, Fan GC*.  Identification of a novel anti-sepsis pathway: Sectm1a enhances macrophage phagocytosis of bacteria through activating GITR. J Immunol. 2020, 205(6):1633-1643.
  23. Li Y, Deng S, Wang X, Huang W, Chen J, Robbins N, Mu X, Essandoh E, Peng T, Jegga AG, Rubinstein J, Adams DE, Wang Y, Peng J, Fan GC*.  Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signaling in macrophages. Cardiovasc Res. 2021,117(3): 890-902.
  24. Mu X, Fan H, Wang P, Li Y, Domenico K, Li Q, Wang X, Essandoh K, Chen J, Peng T, Fan GC*. Sectm1a facilitates protection against inflammation-induced organ damage through promoting tissue-resident macrophage self-renewal. Mol Ther. 2021, 29(3):1294-1311.
  25. Wang P, Mu X, Zhao H, Li Y, Wang L, Wolfe V, Cui S-N, Wang X, Peng T, Zingarelli B, Wang C, Fan GC*. Administration of GDF3 into septic mice improves survival via enhancing macrophage phagocytosis through activation of the LXR-a pathway. Front Immunol., 2021;12: E647070.
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