HDL cartoon

Name: HDL cartoon.

Description:  We think this is a better representation of HDL composition and structure than most cartoons you will find on the internet. It is drawn approximately to scale with protein structures based on our work.

Reference: Huang et al, Nature Structural and Molecular Biology 2011 4; 416-422.

Image file (JPG, 658x658 pixels):  HDL Cartoon

Name: Classic 5/5 double belt model as described by Segrest

Description: Original double belt of two apoA-I molecules on a 96 angstrom rHDL particle. Helix 5 of each antiparellel belt overlap. Note: This model does not include residues 1-43.

Reference: Segrest et al., J Biol Chem. 1999 Nov 5;274(45):31755-8.

Name: Altered registry of 5/5 double belt model as proposed by us.

Description: Two apoA-I molecules on a 96 angstrom rHDL particle. Instead of helix 5 of each antiparellel belt overlapping, helix 5 overlapes with helix 2. Note: This model does not include residues 1-43.

Reference: Silva et al, Biochemistry 2005 44(24); 8600-8607.

Name: ApoA-I, lipid-free homology and cross-linking model.

Description: Full length apoA-I monomer folded as dictated by homology modeling and cross-linking with BS3. This was the first molecular detailed model of lipid-free apoA-I.

Reference: Silva et al, Biochemistry 2005 44(8); 2759-2769.

Name: ApoA-IV, lipid-free homology and cross-linking model.

Description:  Full length apoA-IV monomer folded as dictated by homology modeling and cross-linking with BS3. This was the first molecular detailed model of lipid-free apoA-IV.

Reference: Tubb et al, JBC 2008 283(25); 17314-17323.

Name: ApoA-I Trefoil.

Description: Three apoA-I molecules on a spherical HDL particle. Note: This model does not include residues 1-43 and may include breaks in the sequence.

Reference: Silva et al, PNAS 2008 105(34); 12176-12181.

Name: ApoA-IV 64-335 dimer crystal structure 2.4 Angstroms.
Description: ApoA-IV 64-335 was crystallized as a dimer, revealing an interesting helix swapping dimeric interface.
Reference: Deng et al, Structure 2012 20(5); 767-779.

Name: ApoA-I 1-185 deletion mutant dimer and monomer.

Description: The deletion mutant of apoA-I that was crystallized by Mei et al was evaluated in solution both as a dimer and monomer by isotope-assisted chemical crosslinking and SAXS.

Reference: Melchior et al, JBC 2016 291(10); 5439-5451.

Name: Full-length, lipid-free human apoA-I consensus model.

Description: This model was generated by combining cross-linking data from 3 laboratories as well as SAXS, HDX and X-ray crystallography data. It was generated in a collaborative effort from 8 different lipoprotein structural biology groups.

Reference: Melchior et al, Nature Structure and Molecular Biology 2017 24:1093-1099.