Human Health Risk Assessment
Risk Science Center scientists combine a practitioner’s knowledge of the issues and pitfalls involved in the development of human health risk assessments, together with cutting-edge toxicology expertise, to develop state-of-the-science assessments. Our research, aimed at improving risk assessment methods particularly in the areas of dose-response and mode of action, further enhance our analyses. In solving risk problems for a diverse array of government and private sponsors, we apply a collaborative philosophy that emphasizes partnership building, allowing us to expand our pool of expertise, build on multiple perspectives, and ensure the use of the best science. These strengths form the basis for our development of independent and science-driven analyses for a range of risk assessment products such as screening-level assessments, dossiers for HPV and REACH, occupational assessments, and in-depth evaluations considering mechanistic data and using sophisticated modeling techniques.
Risk Methods Development
The field of risk assessment is changing rapidly as the "omics" revolution and the burgeoning field of molecular toxicology provide a wealth of data that were not traditionally available.
The Risk Science Center's research seeks to enhance the use of data on mode and mechanism of action to inform qualitative and quantitative aspects of risk assessment. We do this by designing targeted studies and decision frameworks to address key MOA questions, incorporating biomarker data to extend the dose-response curve using advanced PBPK and BBDR modeling approaches, and developing approaches to evaluate health risk assessment for potentially-susceptible populations and other areas of uncertainty in risk assessment.
Occupational Risk & Exposure
Although a number of U.S. organizations develop occupational exposure limits (OELs), much of the effort has focused on a relatively small subset of high volume chemicals, or those with particularly severe toxic endpoints. As a result, many workers are exposed to substances for which no guidance on acceptable exposure levels has been developed. The Risk Science Center uses the best available science to develop risk values to protect worker and public health. The Center's goal is to work cooperatively with other organizations’ efforts to see that more OELs are developed and take full advantage of advances in risk assessment methods. We work to support OEL development through two distinct programs: development of sound OELs by Center staff, and organizing independent peer reviews of values developed by others.
At the Risk Science Center, we embrace the principles of Green Chemistry to help our sponsors design products and processes that reduce or eliminate the generation of hazardous substances. We offer systematic approaches to weighing comparative health and environmental risks, to help prevent waste, design safer products, and minimize the potential for accidents.