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Department of

Surgery

Photo of Dorothy Supp, PhD

Dorothy Supp, PhD

Research Professor (Adjunct); Investigator, Shriners Hospitals for Children - Cincinnati

Education/Credentials
  • B.S.: Cornell University, College of Agriculture and Life Sciences
  • PhD.: University of Cincinnati College of Medicine
  • Postdoctoral Fellowship: Childrens Hospital Research Foundation

Contact Information
  • Shriners Hospitals for Children - Cincinnati
  • 3229 Burnet Avenue
  • Cincinnati, Ohio 45229-3095
  • Email dorothy.supp@uc.edu

Peer Reviewed Publications

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Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M 2015. Burn Scar Biomechanics Following Pressure Garment Therapy. Plastic and reconstructive surgery, ,

Alexander, J Wesley; Supp, Dorothy M 2014. Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection. Advances in wound care, 3 11, 682-690

Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, ,

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370

Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664

Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5

Supp, Dorothy M 2012. Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes. Advances in wound care, 1 2, 63-68

Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T 2012. LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, 12 , e19

Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plastic and reconstructive surgery, 129 6, 1259-71

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62

Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601

Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92

Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4. Burns : journal of the International Society for Burn Injuries, 35 7, 949-55

Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93

Powell, Heather M; Supp, Dorothy M; Boyce, Steven T 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials, 29 7, 834-43

Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman 2007. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1545-51

Supp, Dorothy M 2007. Gene therapy to fight infection in skin transplants. Pharmacogenomics, 8 5, 483-6

Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns : journal of the International Society for Burn Injuries, 32 2, 135-8

Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. The Journal of investigative dermatology, 125 6, 1286-301

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns : journal of the International Society for Burn Injuries, 30 7, 643-8

Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 8, 797-804

Supp, D M; Supp, A P; Bell, S M; Boyce, S T 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. The Journal of investigative dermatology, 114 1, 5-13

Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M . Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51

Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M . Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44

McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association, 32 4, 498-508

McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 16 4, 534-41

Smiley, Andrea K; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N; Supp, Dorothy M . Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity. Journal of burn care & research : official publication of the American Burn Association, 28 1, 127-32

Supp, Andrew P; Neely, Alice N; Supp, Dorothy M; Warden, Glenn D; Boyce, Steven T . Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 26 3, 238-46

Supp, D M; Bell, S M; Morgan, J R; Boyce, S T . Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 8 1, 26-35

Supp, Dorothy M; Boyce, Steven T . Engineered skin substitutes: practices and potentials. Clinics in dermatology, 23 4, 403-12

Supp, Dorothy M; Boyce, Steven T . Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. The Journal of burn care & rehabilitation, 23 1, 10-20

Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Glaser, Kathryn . Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes. Journal of burn care & research : official publication of the American Burn Association, 35 1, 84-92

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T . Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 25 4, 337-45