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Department of

Neurology and Rehabilitation Medicine

Photo of  Joseph Clark, PhD

Joseph Clark, PhD

Professor of Neurology

Education/Credentials
  • Bachelor's Degree: Susquehanna University
  • Athletic Training Certification (ATC): Susquehanna University
  • Master's Degree: Michigan State University
  • Doctoral Degree: Michigan State University
  • Fellowship: Centre University de Paris Sud
  • Fellowship: University of Oxford

Research/Clinical Interests

Neurology

Board Certifications & Licenses
  • Certified Athletic Trainer National Athletic Trainer's Association, 1984
Contact Information
  • Medical Sciences Building
  • Room 7112
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-7009
  • Email joseph.clark@uc.edu

Peer Reviewed Publications

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Brewster, Lizzy M; Coronel, Carmen M D; Sluiter, Willem; Clark, Joseph F; van Montfrans, Gert A 2012. Ethnic differences in tissue creatine kinase activity: an observational study. PloS one, 7 3, e32471

Clark, Joseph F; Ellis, James K; Bench, Johnny; Khoury, Jane; Graman, Pat 2012. High-performance vision training improves batting statistics for university of cincinnati baseball players. PloS one, 7 1, e29109

Kurosawa, Yuko; Degrauw, Ton J; Lindquist, Diana M; Blanco, Victor M; Pyne-Geithman, Gail J; Daikoku, Takiko; Chambers, James B; Benoit, Stephen C; Clark, Joseph F 2012. Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency. The Journal of clinical investigation, ,

Suofu, Y; Clark, J F; Broderick, J P; Kurosawa, Y; Wagner, K R; Lu, A 2012. Matrix metalloproteinase-2 or -9 deletions protect against hemorrhagic transformation during early stage of cerebral ischemia and reperfusion. Neuroscience, 212 , 180-9

Alla, Suresh K; Huddle, Adam; Butler, Joshua D; Bowman, Peggy S; Clark, Joseph F; Beyette, Fred R 2011. Point-of-care device for quantification of bilirubin in skin tissue. IEEE transactions on bio-medical engineering, 58 3, 777-80

Beyette, Fred R; Booher, Blaine; Drennan, James; Carraher, Lee; Butler, Josh; Bowman, Peggy S; Clark, Joseph F; Wilsey, Philip A 2011. Device for quantification of bilirubin in cerebral spinal fluid. IEEE transactions on bio-medical engineering, 58 3, 773-6

Brewster, Lizzy M; Clark, Joseph F; van Montfrans, Gert A 2011. The Tromsø study confirms the association between creatine kinase and blood pressure. Journal of hypertension, 29 5, 1019; author reply 1

Butler, Joshua; Booher, Blaine; Bowman, Peggy S; Clark, Joseph F; Beyette, Fred R 2011. Improved quantification of CSF bilirubin in the presence of hemoglobin using least squares curve-fitting. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2011 , 1-4

Clark, Joseph F; Harm, Amanda; Saffire, Ashlie; Biehle, Susan J; Lu, Aigang; Pyne-Geithman, Gail J 2011. Bilirubin oxidation products seen post subarachnoid hemorrhage have greater effects on aged rat brain compared to young. Acta neurochirurgica. Supplement, 110 Pt 1, 157-62

Loftspring, Matthew C; Johnson, Holly L; Feng, Rui; Johnson, Aaron J; Clark, Joseph F 2011. Unconjugated bilirubin contributes to early inflammation and edema after intracerebral hemorrhage. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 31 4, 1133-42

Skelton, Matthew R; Schaefer, Tori L; Graham, Devon L; Degrauw, Ton J; Clark, Joseph F; Williams, Michael T; Vorhees, Charles V 2011. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PloS one, 6 1, e16187

Alla, Suresh K; Huddle, Adam; Clark, Joseph F; Beyette, Fred R 2010. Signal processing system to quantify bilirubin in the jaundice clinical model spectra. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2010 , 1356-9

Beyette, Fred R; Booher, Blaine; Drennan, James; Carraher, Lee; Butler, Josh; Bowman, Peggy; Clark, Joseph F; Wilsey, Philip A 2010. Development of a point-of-care device for the quantification of bilirubin in cerebral spinal fluid. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2010 , 915-8

Brewster, L M; Taherzadeh, Z; Volger, S; Clark, J F; Rolf, T; Wolf, H; Vanbavel, E; van Montfrans, G A 2010. Ethnic differences in resistance artery contractility of normotensive pregnant women. American journal of physiology. Heart and circulatory physiology, 299 2, H431-6

Hou, Shangwei; Xu, Rong; Clark, Joseph F; Wurster, William L; Heinemann, Stefan H; Hoshi, Toshinori 2010. Bilirubin oxidation end products directly alter K(+) channels important in the regulation of vascular tone. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, ,

Kroening, Karolin K; Kuhlmann, Julia; Easter, Renee; Clark, Joseph F; Pyne-Geithman, Gail; Caruso, Joseph A 2010. Protein phosphorylation studies of cerebral spinal fluid for potential biomarker development. Metallomics : integrated biometal science, 2 5, 334-41

Kroening, Karolin K; Kuhlmann, Julia; Easter, Renee; Clark, Joseph F; Pyne-Geithman, Gail; Caruso, Joseph A 2010. Protein phosphorylation studies of cerebral spinal fluid for potential biomarker development. Metallomics : integrated biometal science, 2 5, 334-41

Kurosawa, Yuko; Lu, Aigang; Khatri, Pooja; Carrozzella, Janice A; Clark, Joseph F; Khoury, Jane; Tomsick, Thomas A 2010. Intra-arterial iodinated radiographic contrast material injection administration in a rat middle cerebral artery occlusion and reperfusion model: possible effects on intracerebral hemorrhage. Stroke; a journal of cerebral circulation, 41 5, 1013-7

Loftspring, Matthew C; Hansen, Craig; Clark, Joseph F 2010. A novel brain injury mechanism after intracerebral hemorrhage: the interaction between heme products and the immune system. Medical hypotheses, 74 1, 63-6

McMullan, Jason T; Knight, William A; Clark, Joseph F; Beyette, Fred R; Pancioli, Arthur 2010. Time-critical neurological emergencies: the unfulfilled role for point-of-care testing. International journal of emergency medicine, 3 2, 127-31

Zhang, Yaofang; Clark, Joseph F; Pyne-Geithman, Gail; Caruso, Joseph 2010. Metallomics study in CSF for putative biomarkers to predict cerebral vasospasm. Metallomics : integrated biometal science, 2 9, 628-37

Alla, Suresh K; Clark, Joseph F; Beyette, Fred R 2009. Signal processing system to extract serum bilirubin concentration from diffuse reflectance spectrum of human skin. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009 , 1290-3

Loftspring,M. C., McDole,J., Lu,A., Clark,J. F., Johnson,A. J. 2009. Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 29 1, 137

Lu, Aigang; Clark, Joseph F; Broderick, Joseph P; Pyne-Geithman, Gail J; Wagner, Kenneth R; Khatri, Pooja; Tomsick, Thomas; Sharp, Frank R 2009. Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brain. Experimental neurology, 216 2, 407-12

Lu, Aigang; Clark, Joseph F; Ran, Ruiqiong; Pyne-Geithman, Gail; Wagner, Kenneth R; Millhorn, David E; Sharp, Frank R 2009. Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependent. Neurological research, 31 5, 545-9

Pyne-Geithman, Gail J; Caudell, Danielle N; Cooper, Matthew; Clark, Joseph F; Shutter, Lori A 2009. Dopamine D2-receptor-mediated increase in vascular and endothelial NOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in vitro. Neurocritical care, 10 2, 225-31

Pyne-Geithman, Gail J; Caudell, Danielle N; Prakash, Porus; Clark, Joseph F 2009. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurological research, 31 2, 195-9

Brewster,L. M., van Bree,S., Reijneveld,J. C., Notermans,N. C., Verschuren,W. M., Clark,J. F., van Montfrans,G. A., de Visser,M. 2008. Hypertension risk in idiopathic hyperCKemia Journal of neurology, 255 1, 11

Clark,J. F., Loftspring,M., Wurster,W. L., Beiler,S., Beiler,C., Wagner,K. R., Pyne-Geithman,G. J. 2008. Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage Acta neurochirurgica.Supplement, 105 , 7

Clark,J. F., Loftspring,M., Wurster,W. L., Pyne-Geithman,G. J. 2008. Chemical and biochemical oxidations in spinal fluid after subarachnoid hemorrhage Frontiers in bioscience : a journal and virtual library, 13 , 1806

Ellis,J., Del Castillo,E., Montes Bayon,M., Grimm,R., Clark,J. F., Pyne-Geithman,G., Wilbur,S., Caruso,J. A. 2008. A preliminary study of metalloproteins in CSF by CapLC-ICPMS and NanoLC-CHIP/ITMS Journal of proteome research, 7 9, 3747

Ellis,J., Grimm,R., Clark,J. F., Pyne-Gaithman,G., Wilbur,S., Caruso,J. A. 2008. Studying protein phosphorylation in low MW CSF fractions with capLC-ICPMS and nanoLC-CHIP-ITMS for identification of phosphoproteins Journal of proteome research, 7 11, 4736

Lu,A., Clark,J. F., Broderick,J. P., Pyne-Geithman,G. J., Wagner,K. R., Ran,R., Khatri,P., Tomsick,T., Sharp,F. R. 2008. Reperfusion activates metalloproteinases that contribute to neurovascular injury Experimental neurology, 210 2, 549

Pyne-Geithman,G. J., Nair,S. G., Caudell,D. N., Clark,J. F. 2008. PKC and Rho in vascular smooth muscle: activation by BOXes and SAH CSF Frontiers in bioscience : a journal and virtual library, 13 , 1526

Wurster,W. L., Pyne-Geithman,G. J., Peat,I. R., Clark,J. F. 2008. Bilirubin oxidation products (BOXes): synthesis, stability and chemical characteristics Acta neurochirurgica.Supplement, 104 , 43

Bhadri,P. R., Salgaonkar,V. A., Pyne-Geithman,G. J., Caffery,J. J.,Jr, Shukla,R., Beyette,F. R.,Jr, Clark,J. F. 2007. Spectrophotometric quantification of bilirubin in hemorrhagic spinal fluid using an innovative algorithm Medicinal chemistry (Shariqah (United Arab Emirates)), 3 1, 21

Loftspring,M. C., Clark,J. F., Wagner,K. R. 2007. A novel duplex ELISA method for quantitation of plasma proteins in areas of brain edema Brain research, 1162 , 130

Loftspring,M. C., Wurster,W. L., Pyne-Geithman,G. J., Clark,J. F. 2007. An in vitro model of aneurysmal subarachnoid hemorrhage: oxidation of unconjugated bilirubin by cytochrome oxidase Journal of neurochemistry, 102 6, 1990

Brewster,L. M., Mairuhu,G., Bindraban,N. R., Koopmans,R. P., Clark,J. F., van Montfrans,G. A. 2006. Creatine kinase activity is associated with blood pressure Circulation, 114 19, 2034

Clark,J. F., Doepke,A., Filosa,J. A., Wardle,R. L., Lu,A., Meeker,T. J., Pyne-Geithman,G. J. 2006. N-acetylaspartate as a reservoir for glutamate Medical hypotheses, 67 3, 506

Clark,J. F., Sharp,F. R. 2006. Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhage Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 26 10, 1223

Field,M. L., Khan,O., Abbaraju,J., Clark,J. F. 2006. Functional compartmentation of glycogen phosphorylase with creatine kinase and Ca2+ ATPase in skeletal muscle Journal of theoretical biology, 238 2, 257

Clark,J. F., Pyne-Geithman,G. 2005. Vascular smooth muscle function: The physiology and pathology of vasoconstriction Pathophysiology : the official journal of the International Society for Pathophysiology / ISP, 12 1, 35

Newmeyer,A., Cecil,K. M., Schapiro,M., Clark,J. F., Degrauw,T. J. 2005. Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imaging Journal of developmental and behavioral pediatrics : JDBP, 26 4, 276

Pyne-Geithman,G. J., Morgan,C. J., Wagner,K., Dulaney,E. M., Carrozzella,J., Kanter,D. S., Zuccarello,M., Clark,J. F. 2005. Bilirubin production and oxidation in CSF of patients with cerebral vasospasm after subarachnoid hemorrhage Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 25 8, 1070

Biehle,S. J., Carrozzella,J., Shukla,R., Popplewell,J., Swann,M., Freeman,N., Clark,J. F. 2004. Apolipoprotein E isoprotein-specific interactions with tissue plasminogen activator Biochimica et biophysica acta, 1689 3, 244

Jain,S., Jayasimhulu,K., Clark,J. F. 2004. Metabolomic analysis of molecular species of phospholipids from normotensive and preeclamptic human placenta electrospray ionization mass spectrometry Frontiers in bioscience : a journal and virtual library, 9 , 3167

Lyons,M. A., Shukla,R., Zhang,K., Pyne,G. J., Singh,M., Biehle,S. J., Clark,J. F. 2004. Increase of metabolic activity and disruption of normal contractile protein distribution by bilirubin oxidation products in vascular smooth-muscle cells Journal of neurosurgery, 100 3, 505

Morgan,C. J., Pyne-Geithman,G. J., Jauch,E. C., Shukla,R., Wagner,K. R., Clark,J. F., Zuccarello,M. 2004. Bilirubin as a cerebrospinal fluid marker of sentinel subarachnoid hemorrhage: a preliminary report in pigs Journal of neurosurgery, 101 6, 1026

Pyne-Geithman,G. J., deGrauw,T. J., Cecil,K. M., Chuck,G., Lyons,M. A., Ishida,Y., Clark,J. F. 2004. Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study Molecular and cellular biochemistry, 262 1-2, 35

Cecil,K. M., DeGrauw,T. J., Salomons,G. S., Jakobs,C., Egelhoff,J. C., Clark,J. F. 2003. Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency Journal of computer assisted tomography, 27 1, 44

Kreider,R. B., Burke,E. R., Clark,J. F., Earnest,C., Greenwood,M., Harris,R., Kalman,D. S., Kleiner,S. M., Serrano,E., Volek,J. S., Ziegenfuss,T. N., Willoughby,D. S. 2003. The neurosurgeon in sport: awareness of the risks of heatstroke and dietary supplements Neurosurgery, 52 1, 252

Lu,A., Tang,Y., Ran,R., Clark,J. F., Aronow,B. J., Sharp,F. R. 2003. Genomics of the periinfarction cortex after focal cerebral ischemia Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23 7, 786

Nakayama,S., Clark,J. F. 2003. Smooth muscle and NMR review: an overview of smooth muscle metabolism Molecular and cellular biochemistry, 244 1-2, 17

Nakayama,S., Nomura,H., Smith,L. M., Clark,J. F., Uetani,T., Matsubara,T. 2003. Mechanisms for monovalent cation-dependent depletion of intracellular Mg2+:Na(+)-independent Mg2+ pathways in guinea-pig smooth muscle The Journal of physiology, 551 Pt 3, 843

Pyne,G. J., Cadoux-Hudson,T. A., Clark,J. F. 2003. Platelets play an essential role in the aetiology of cerebral vasospasm after subarachnoid haemorrhage Medical hypotheses, 60 4, 525

Wagner,K. R., Sharp,F. R., Ardizzone,T. D., Lu,A., Clark,J. F. 2003. Heme and iron metabolism: role in cerebral hemorrhage Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23 6, 629

Clark,J. F., Huri,D. A., Carrozzella,J., Jauch,E. C., Mehta,P., Heaton,D., Biehle,S. J., Broderick,J. P. 2002. Isoforms of apolipoprotein E can modulate tPA-induced clot lysis in vitro Frontiers in bioscience : a journal and virtual library, 7 , a163

Clark,J. F., Reilly,M., Sharp,F. R. 2002. Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: a contributor to subarachnoid hemorrhage-induced vasospasm Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 22 4, 472

Nakayama,S., Nomura,H., Smith,L. M., Clark,J. F. 2002. Simultaneous estimation of intracellular free Mg2+ and pH by use of a new pH-dependent dissociation constant of MgATP The Japanese journal of physiology, 52 3, 323

Cadoux-Hudson,T. A., Pyne,G. J., Domingo,Z., Clark,J. F. 2001. The stimulation of vascular smooth muscle oxidative metabolism by CSF from subarachnoid haemorrhage patients increases with Fisher and WFNS grades Acta Neurochirurgica, 143 1, 65

Clark,J. F., Pyne,G. J., Choutka,J., Carrozzella,J. A., Khoury,J., Broderick,J. P., Cadoux-Hudson,T. A. 2001. In vitro therapy with dobutamine, isoprenaline and sodium nitroprusside protects vascular smooth muscle metabolism from subarachnoid haemorrhage induced cerebral vasospasm Acta Neurochirurgica, 143 7, 721

Pyne,G. J., Cadoux-Hudson,T. A., Clark,J. F. 2001. Cerebrospinal fluid from subarachnoid haemorrhage patients causes excessive oxidative metabolism compared to vascular smooth muscle force generation Acta Neurochirurgica, 143 1, 59

Pyne,G. J., Cadoux-Hudson,T. A., Clark,J. F. 2001. Magnesium protection against in vitro cerebral vasospasm after subarachnoid haemorrhage British journal of neurosurgery, 15 5, 409

Brewster,L. M., Clark,J. F., van Montfrans,G. A. 2000. Is greater tissue activity of creatine kinase the genetic factor increasing hypertension risk in black people of sub-Saharan African descent? Journal of hypertension, 18 11, 1537

Clark,J. F., Matsumoto,T., Nakayama,S. 2000. Intact smooth muscle metabolism: its responses to cyanide poisoning and pyruvate stimulation Frontiers in bioscience : a journal and virtual library, 5 , A18

Clark,J. F., Radda,G. K., Boehm,E. A. 2000. The effects of anti-hypertensive therapy on the structural, mechanical and metabolic properties of the rat aorta Journal of muscle research and cell motility, 21 3, 255

Kranc,K. R., Pyne,G. J., Tao,L., Claridge,T. D., Harris,D. A., Cadoux-Hudson,T. A., Turnbull,J. J., Schofield,C. J., Clark,J. F. 2000. Oxidative degradation of bilirubin produces vasoactive compounds European journal of biochemistry / FEBS, 267 24, 7094

Pyne,G. J., Cadoux-Hudson,T. A., Clark,J. F. 2000. The presence of an extractable substance in the CSF of humans with cerebral vasospasm after subarachnoid haemorrhage that correlates with phosphatase inhibition Biochimica et biophysica acta, 1474 3, 283

Thomson,N. F., Thornton,S., Clark,J. F. 2000. The effects of placental extracts from normotensive and preeclamptic women on vasoconstriction and oxidative metabolism American Journal of Obstetrics and Gynecology, 183 1, 206

Kunz,W. S., Kuznetsov,A. V., Clark,J. F., Tracey,I., Elger,C. E. 1999. Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-deficient Mo(vbr) mice Journal of neurochemistry, 72 4, 1580

Bearchell,M. C., Redman,C. W., Pyne,G. J., Cadoux-Hudson,T., Clark,J. F. 1998. Vascular smooth muscle oxygen consumption is reversibly stimulated by sera from women with preeclampsia American Journal of Obstetrics and Gynecology, 179 6 Pt 1, 1534

Clark,J. F. 1998. Creatine: a review of its nutritional applications in sport Nutrition (Burbank, Los Angeles County, Calif.), 14 3, 322

Kemp,G. J., Manners,D. N., Clark,J. F., Bastin,M. E., Radda,G. K. 1998. Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle Molecular and cellular biochemistry, 184 1-2, 249

Clark,J. F. 1997. Creatine and Phosphocreatine: A Review of Their Use in Exercise and Sport Journal of athletic training, 32 1, 45

Clark,J. F., Kuznetsov,A. V., Radda,G. K. 1997. ADP-regenerating enzyme systems in mitochondria of guinea pig myometrium and heart The American Journal of Physiology, 272 2 Pt 1, C399

Field,M. L., Clark,J. F. 1997. Inappropriate ubiquitin conjugation: a proposed mechanism contributing to heart failure Cardiovascular research, 33 1, 8

Kemp,G. J., Manners,D. N., Clark,J. F., Bastin,M. E., Radda,G. K. 1997. A theoretical model of some spatial and temporal aspects of the mitochondrion creatine kinase myofibril system in muscle Molecular and cellular biochemistry, 174 1-2, 29

Nakayama,S., Chihara,S., Clark,J. F., Huang,S. M., Horiuchi,T., Tomita,T. 1997. Consequences of metabolic inhibition in smooth muscle isolated from guinea-pig stomach The Journal of physiology, 505 ( Pt 1) Pt 1, 229

Boehm,E. A., Radda,G. K., Tomlin,H., Clark,J. F. 1996. The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase Biochimica et biophysica acta, 1274 3, 119

Kuznetsov,A. V., Clark,J. F., Winkler,K., Kunz,W. S. 1996. Increase of flux control of cytochrome c oxidase in copper-deficient mottled brindled mice The Journal of biological chemistry, 271 1, 283

Leighton,B., Sanderson,A. L., Young,M. E., Radda,G. K., Boehm,E. A., Clark,J. F. 1996. Effects of treatment of spontaneously hypertensive rats with the angiotensin-converting enzyme inhibitor trandolapril and the calcium antagonist verapamil on the sensitivity of glucose metabolism to insulin in rat soleus muscle in vitro Diabetes, 45 Suppl 1 , S120

Boehm,E. A., Clark,J. F., Radda,G. K. 1995. Metabolite utilization and compartmentation in porcine carotid artery: a study using beta-guanidinopropionic acid The American Journal of Physiology, 268 3 Pt 1, C628

Clark,J. F., Dillon,P. F. 1995. Phosphocreatine and creatine kinase in energetic metabolism of the porcine carotid artery Journal of vascular research, 32 1, 24

Clark,J. F., Kemp,G. J., Radda,G. K. 1995. The creatine kinase equilibrium, free [ADP] and myosin ATPase in vascular smooth muscle cross-bridges Journal of theoretical biology, 173 2, 207

Clark,J. F. 1994. The creatine kinase system in smooth muscle Molecular and cellular biochemistry, 133-134 , 221

Clark,J. F., Khuchua,Z., Boehm,E., Ventura-Clapier,R. 1994. Creatine kinase activity associated with the contractile proteins of the guinea-pig carotid artery Journal of muscle research and cell motility, 15 4, 432

Clark,J. F., Khuchua,Z., Kuznetsov,A. V., Vassil'eva,E., Boehm,E., Radda,G. K., Saks,V. 1994. Actions of the creatine analogue beta-guanidinopropionic acid on rat heart mitochondria The Biochemical journal, 300 ( Pt 1) Pt 1, 211

Clark,J. F., Kuznetsov,A. V., Khuchua,Z., Veksler,V., Ventura-Clapier,R., Saks,V. 1994. Creatine kinase function in mitochondria isolated from gravid and non-gravid guinea-pig uteri FEBS letters, 347 2-3, 147

Field,M. L., Clark,J. F., Henderson,C., Seymour,A. M., Radda,G. K. 1994. Alterations in the myocardial creatine kinase system during chronic anaemic hypoxia Cardiovascular research, 28 1, 86

Clark,J. F., Khuchua,Z., Kuznetsov,A., Saks,V. A., Ventura-Clapier,R. 1993. Compartmentation of creatine kinase isoenzymes in myometrium of gravid guinea-pig The Journal of physiology, 466 , 553

Clark,J. F., Khuchua,Z., Ventura-Clapier,R. 1992. Creatine kinase binding and possible role in chemically skinned guinea-pig taenia coli Biochimica et biophysica acta, 1100 2, 137

Khuchua,Z. A., Vasiljeva,E. V., Clark,J. F., Korchazhkina,O. V., Branishte,T., Kapelko,V. I., Kuznetsov,A. V., Ventura-Clapier,R., Steinschneider,A. Ya, Lakomkin,V. L. 1992. The creatine kinase system and cardiomyopathy The American Journal of Cardiovascular Pathology, 4 3, 223

Clark,J. F., Harris,G. I., Dillon,P. F. 1991. Multisite saturation transfer using DANTE and continuous wave Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 17 1, 274

Dillon,P. F., Clark,J. F. 1990. The theory of diazymes and functional coupling of pyruvate kinase and creatine kinase Journal of theoretical biology, 143 2, 275

Dillon,P. F., Fisher,M. J., Adams,G. R., Clark,J. F. 1989. The use of 31P-NMR to study smooth muscle Progress in clinical and biological research, 315 , 439