Education/CredentialsFellowship: University of Cincinnati College of MedicineDoctoral Degree: St. Thomas Institute (The biological and immunological activities of phospholipids)Bachelor's Degree: St. Joseph's College (Biology-Chemistry) Contact Information Email cushiomt@ucmail.uc.edu Research InterestsFungi in the genus Pneumocystis cause an oftentimes lethal pneumonia (PCP) in humans and other mammals with compromised immune status. The niche of these fungi include patients with underlying chronic diseases such as COPD or HIV and those receiving anti-inflammatory or immunosuppressive agents. PCP is not responsive to standard antifungal therapy with few treatment alternatives besides trimethoprim-sulfamethoxazole. My laboratory focuses on pre-clinical drug development that inc... Peer Reviewed Publications Cissé, Ousmane H; Curran, Shelly J; Folco, H Diego; Liu, Yueqin; Bishop, Lisa; Wang, Honghui; Fischer, Elizabeth R; Davis, A Sally; Combs, Christian; Thapar, Sabrina; Dekker, John P; Grewal, Shiv; Cushion, Melanie; Ma, Liang; Kovacs, Joseph A 2024. Regional centromere configuration in the fungal pathogens of the Pneumocystis genus. mBio, , e0318523Sayson, Steven G; Ashbaugh, Alan; Cushion, Melanie T 2024. Extracellular vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions. Microbiology spectrum, 12 2, e0365323Sayson, Steven G; Ashbaugh, Alan; Porollo, Aleksey; Cushion, Melanie T 2024. Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia. bioRxiv : the preprint server for biology, , Cissé, Ousmane H; Curran, Shelly; Folco, H Diego; Liu, Yueqin; Bishop, Lisa; Wang, Honghui; Fischer, Elizabeth R; Davis, A Sally; Babb-Biernacki, Spenser; Doyle, Vinson P; Richards, Jonathan K; Hassan, Sergio A; Dekker, John P; Khil, Pavel P; Brenchley, Jason M; Grewal, Shiv; Cushion, Melanie; Ma, Liang; Kovacs, Joseph A 2023. The Host Adapted Fungal Pathogens of Pneumocystis Genus Utilize Genic Regional Centromeres. bioRxiv : the preprint server for biology, , Meier, Caroline S; Pagni, Marco; Richard, Sophie; Mühlethaler, Konrad; Almeida, João M G C F; Nevez, Gilles; Cushion, Melanie T; Calderón, Enrique J; Hauser, Philippe M 2023. Publisher Correction: Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 1, 7928Meier, Caroline S; Pagni, Marco; Richard, Sophie; Mühlethaler, Konrad; Almeida, João M G C F; Nevez, Gilles; Cushion, Melanie T; Calderón, Enrique J; Hauser, Philippe M 2023. Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 1, 7026Sayson, Steven G; Ashbaugh, Alan; Cushion, Melanie T 2023. Extracellular Vesicles from Pneumocystis carinii -Infected Rats Impair Fungal Viability but are Dispensable for Macrophage Functions. bioRxiv : the preprint server for biology, , Wiederhold, Nathan P; Patterson, Thomas F; Rebholz, Sandra; Brennan, James; Patton, Thomas; Barrett, John; Boal, Connell W C; Ehrensberger, Monika; Boyle, Ryan; Cushion, Melanie T 2023. Erratum for Wiederhold et al., "The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate)". Antimicrobial agents and chemotherapy, 67 2, e0147522Cushion, Melanie T; Ashbaugh, Alan; Sayson, Steven G; Mosley, Christopher; Hauser, Philippe M 2022. Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication. Microbiology spectrum, 10 6, e0290622Macioce-Tisdale, Nikeya L; Ashbaugh, Alan; Hendrix, Keeley; Collins, Margaret S; Porollo, Aleksey; Cushion, Melanie T 2022. The Effects of Sex and Strain on Pneumocystis murina Fungal Burdens in Mice. Journal of fungi (Basel, Switzerland), 8 10, Wiederhold, Nathan P; Patterson, Thomas F; Rebholz, Sandra; Boal, Connell W C; Ehrensberger, Monika; Boyle, Ryan; Cushion, Melanie T 2022. The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate). Antimicrobial agents and chemotherapy, 66 8, e0052122Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. Genomic insights into the host specific adaptation of the Pneumocystis genus. Communications biology, 4 1, 305Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. Genomic insights into the host specific adaptation of the Pneumocystis genus. Communications biology, 4 1, 305Cushion, Melanie T; Ashbaugh, Alan 2021. The Long-Acting Echinocandin, Rezafungin, Prevents Pneumocystis Pneumonia and Eliminates Pneumocystis from the Lungs in Prophylaxis and Murine Treatment Models. Journal of fungi (Basel, Switzerland), 7 9, Cushion, Melanie T; Tisdale-Macioce, Nikeya; Sayson, Steven G; Porollo, Aleksey 2021. The Persistent Challenge of Pneumocystis Growth Outside the Mammalian Lung: Past and Future Approaches. Frontiers in microbiology, 12 , 681474Miesel, Lynn; Cushion, Melanie T; Ashbaugh, Alan; Lopez, Santiago R; Ong, Voon 2021. Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia. Antimicrobial agents and chemotherapy, 65 3, Tisdale-Macioce, Nikeya; Green, Jenna; Perl, Anne-Karina T; Ashbaugh, Alan; Wiederhold, Nathan P; Patterson, Thomas F; Cushion, Melanie T 2021. The Promise of Lung Organoids for Growth and Investigation of Pneumocystis Species. Frontiers in fungal biology, 2 , 740845Cushion, Melanie T; Kumar, Parag; Lu, Ruying; Ashbaugh, Alan; Adeojo, Lilian W; Alfaro, Raul; Mannino, Raphael; Tramont, Edmund; Kovacs, Joseph A 2020. A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia. The Journal of infectious diseases, , Ma, Liang; Chen, Zehua; Huang, Da Wei; Cissé, Ousmane H; Rothenburger, Jamie L; Latinne, Alice; Bishop, Lisa; Blair, Robert; Brenchley, Jason M; Chabé, Magali; Deng, Xilong; Hirsch, Vanessa; Keesler, Rebekah; Kutty, Geetha; Liu, Yueqin; Margolis, Daniel; Morand, Serge; Pahar, Bapi; Peng, Li; Van Rompay, Koen K A; Song, Xiaohong; Song, Jun; Sukura, Antti; Thapar, Sabrina; Wang, Honghui; Weissenbacher-Lang, Christiane; Xu, Jie; Lee, Chao-Hung; Jardine, Claire; Lempicki, Richard A; Cushion, Melanie T; Cuomo, Christina A; Kovacs, Joseph A 2020. Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple Pneumocystis Species. mBio, 11 2, Liu, Guan-Sheng; Ballweg, Richard; Ashbaugh, Alan; Zhang, Yin; Facciolo, Joseph; Cushion, Melanie T; Zhang, Tongli 2019. Correction to: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC systems biology, 13 1, 40Luraschi, A; Richard, S; Almeida, J M G C F; Pagni, M; Cushion, M T; Hauser, P M 2019. Expression and Immunostaining Analyses Suggest that Pneumocystis Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors. mBio, 10 4, Cushion, Melanie T 2018. Reply to Nevez et al., "The Fascinating Echinocandin-Treated Mouse Model of Pneumocystis murina To Understand Pneumocystis jirovecii". Antimicrobial agents and chemotherapy, 62 8, Cushion, Melanie T; Ashbaugh, Alan; Hendrix, Keeley; Linke, Michael J; Tisdale, Nikeya; Sayson, Steven G; Porollo, Aleksey 2018. Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation. Antimicrobial agents and chemotherapy, 62 5, Cushion, Melanie T; Limper, Andrew H; Porollo, Aleksey; Saper, Vivian E; Sinai, Anthony P; Weiss, Louis M 2018. The 14th International Workshops on Opportunistic Protists (IWOP 14). The Journal of eukaryotic microbiology, 65 6, 934-939Gomes, Ana; Ferraz, Ricardo; Ficker, Lauren; Collins, Margaret S; Prudêncio, Cristina; Cushion, Melanie T; Teixeira, Cátia; Gomes, Paula 2018. Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial agents and chemotherapy, 62 11, Hauser, Philippe M; Cushion, Melanie T 2018. Is sex necessary for the proliferation and transmission of Pneumocystis? PLoS pathogens, 14 12, e1007409Lazzarini, Cristina; Haranahalli, Krupanandan; Rieger, Robert; Ananthula, Hari Krishna; Desai, Pankaj B; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie T; Ruzsicska, Bela; Haley, John; Ojima, Iwao; Del Poeta, Maurizio 2018. Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids. Antimicrobial agents and chemotherapy, 62 5, Liu, Guan-Sheng; Ballweg, Richard; Ashbaugh, Alan; Zhang, Yin; Facciolo, Joseph; Cushion, Melanie T; Zhang, Tongli 2018. A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC systems biology, 12 1, 77Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio 2018. Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids". mBio, 9 2, Maciejewska, D; Zabinski, J; Rezler, M; Kazmierczak, P; Collins, M S; Ficker, L; Cushion, M T 2017. Correction: Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 11, 2164Maciejewska, D; Zabinski, J; Rezler, M; Kazmierczak, P; Collins, M S; Ficker, L; Cushion, M T 2017. Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 10, 2003-2011Baker, Frazier N; Cushion, Melanie T; Porollo, Aleksey 2016. A Quantitative Model to Estimate Drug Resistance in Pathogens. Journal of fungi (Basel, Switzerland), 2 4, Cushion, Melanie T; Collins, Margaret S; Sesterhenn, Thomas; Porollo, Aleksey; Vadukoot, Anish Kizhakkekkara; Merino, Edward J 2016. Functional Characterization of Pneumocystis carinii Inositol Transporter 1. mBio, 7 6, Koselny, Kristy; Green, Julianne; DiDone, Louis; Halterman, Justin P; Fothergill, Annette W; Wiederhold, Nathan P; Patterson, Thomas F; Cushion, Melanie T; Rappelye, Chad; Wellington, Melanie; Krysan, Damian J 2016. The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis. Antimicrobial agents and chemotherapy, 60 12, 7115-7127Calderon, Enrique J; Cushion, Melanie T; Xiao, Lihua; Lorenzo-Morales, Jacob; Matos, Olga; Kaneshiro, Edna S; Weiss, Louis M 2015. The 13th International Workshops on Opportunistic Protists (IWOP13). The Journal of eukaryotic microbiology, 62 5, 701-9Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio 2015. Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids. mBio, 6 3, e00647Porollo, Aleksey; Sesterhenn, Thomas M; Collins, Margaret S; Welge, Jeffrey A; Cushion, Melanie T 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. mBio, 5 6, e01834Cushion, Melanie T; Keely, Scott P 2013. Assembly and annotation of Pneumocystis jirovecii from the human lung microbiome. mBio, 4 2, e00224Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T 2013. Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infection and immunity, 81 3, 984-95Lobo, Maria Luísa; Esteves, Francisco; de Sousa, Bruno; Cardoso, Fernando; Cushion, Melanie T; Antunes, Francisco; Matos, Olga 2013. Therapeutic potential of caspofungin combined with trimethoprim-sulfamethoxazole for pneumocystis pneumonia: a pilot study in mice. PloS one, 8 8, e70619Weiss, Louis M; Cushion, Melanie T; Didier, Elizabeth; Xiao, Lihua; Marciano-Cabral, Francine; Sinai, Anthony P; Matos, Olga; Calderon, Enrique J; Kaneshiro, Edna S 2013. The 12th International Workshops on Opportunistic Protists (IWOP-12). The Journal of eukaryotic microbiology, 60 3, 298-308Maciejewska, Dorota; Zabinski, Jerzy; Ka?mierczak, Pawel; Rezler, Mateusz; Krassowska-?wiebocka, Barbara; Collins, Margaret S; Cushion, Melanie T 2012. Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics. European journal of medicinal chemistry, 48 , 164-73Porollo, Aleksey; Meller, Jaroslaw; Joshi, Yogesh; Jaiswal, Vikash; Smulian, A George; Cushion, Melanie T 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current drug targets, 13 12, 1575-85Sinai, Anthony P; Kaneshiro, Edna S; Ward, Honorine; Weiss, Louis M; Cushion, Melanie T 2012. The state of research for AIDS-associated opportunistic infections and the importance of sustaining smaller research communities. Eukaryotic cell, 11 2, 90-7Cushion, Melanie T; Collins, Margaret S 2011. Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures. Antimicrobial agents and chemotherapy, 55 10, 4513-8Cushion, Melanie T 2010. Are members of the fungal genus pneumocystis (a) commensals; (b) opportunists; (c) pathogens; or (d) all of the above? PLoS pathogens, 6 9, Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D 2010. Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PloS one, 5 1, e8524Cushion, Melanie T; Stringer, James R 2010. Stealth and opportunism: alternative lifestyles of species in the fungal genus Pneumocystis. Annual review of microbiology, 64 , 431-52Joffrion, Tiffany M; Collins, Margaret S; Sesterhenn, Thomas; Cushion, Melanie T 2010. Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryotic cell, 9 1, 107-15Joffrion, Tiffany M; Cushion, Melanie T 2010. Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii. FEMS microbiology letters, 311 1, 1-9Sesterhenn, Thomas M; Slaven, Bradley E; Keely, Scott P; Smulian, A George; Lang, B Franz; Cushion, Melanie T 2010. Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii. Molecular genetics and genomics : MGG, 283 1, 63-72Beck, James M; Cushion, Melanie T 2009. Pneumocystis workshop: 10th anniversary summary. Eukaryotic cell, 8 4, 446-60Brubaker, R; Redhead, S A; Stringer, J R; Keely, S P; Cushion, M T 2009. Misinformation about Pneumocystis. Clinical and experimental dermatology, 34 7, e426-7Cushion, Melanie T; Collins, Margaret S; Linke, Michael J 2009. Biofilm formation by Pneumocystis spp. Eukaryotic cell, 8 2, 197-206Cushion, Melanie T; Walzer, Peter D 2009. Preclinical drug discovery for new anti-pneumocystis compounds. Current medicinal chemistry, 16 20, 2514-30Huang, Tien L; Vanden Eynde, Jean Jacques; Mayence, Annie; Collins, Margaret S; Cushion, Melanie T; Rattendi, Donna; Londono, Indira; Mazumder, Lakshman; Bacchi, Cyrus J; Yarlett, Nigel 2009. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorganic & medicinal chemistry letters, 19 20, 5884-6Liu, Yu; Leigh, Jessica W; Brinkmann, Henner; Cushion, Melanie T; Rodriguez-Ezpeleta, Naiara; Philippe, Hervé; Lang, B Franz 2009. Phylogenomic analyses support the monophyly of Taphrinomycotina, including Schizosaccharomyces fission yeasts. Molecular biology and evolution, 26 1, 27-34Vale, Nuno; Prudêncio, Miguel; Marques, Catarina A; Collins, Margaret S; Gut, Jiri; Nogueira, Fátima; Matos, Joana; Rosenthal, Philip J; Cushion, Melanie T; do Rosário, Virgílio E; Mota, Maria M; Moreira, Rui; Gomes, Paula 2009. Imidazoquines as antimalarial and antipneumocystis agents. Journal of medicinal chemistry, 52 23, 7800-7Mayence, Annie; Pietka, Aurélie; Collins, Margaret S; Cushion, Melanie T; Tekwani, Babu L; Huang, Tien L; Vanden Eynde, Jean Jacques 2008. Novel bisbenzimidazoles with antileishmanial effectiveness. Bioorganic & medicinal chemistry letters, 18 8, 2658-61Vale, Nuno; Collins, Margaret S; Gut, Jiri; Ferraz, Ricardo; Rosenthal, Philip J; Cushion, Melanie T; Moreira, Rui; Gomes, Paula 2008. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorganic & medicinal chemistry letters, 18 2, 485-8Cushion, Melanie T; Smulian, A George; Slaven, Bradley E; Sesterhenn, Tom; Arnold, Jonathan; Staben, Chuck; Porollo, Aleksey; Adamczak, Rafal; Meller, Jarek 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS one, 2 5, e423Cushion,M.T.; Smulian,A.G.; Slaven,B.E.; Sesterhenn,T.; Arnold,J.; Staben,C.; Porollo,A.; Adamczak,R.; Meller,J. 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite PLoS ONE, 2 , e423Keely, Scott P; Linke, Michael J; Cushion, Melanie T; Stringer, James R 2007. Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription. Fungal genetics and biology : FG & B, 44 9, 905-19Keely,S.P.; Linke,M.J.; Cushion,M.T.; Stringer,J.R. 2007. Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription Fungal genetics and biology : FG & B, , Keely,S.P.; Linke,M.J.; Cushion,M.T.; Stringer,J.R. 2007. Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription Fungal genetics and biology : FG & B, 44 9, 905Tachado, Souvenir D; Zhang, Jianmin; Zhu, Jinping; Patel, Naimish; Cushion, Melanie; Koziel, Henry 2007. Pneumocystis-mediated IL-8 release by macrophages requires coexpression of mannose receptors and TLR2. Journal of leukocyte biology, 81 1, 205-11Cushion, Melanie T; Smulian, A George 2006. Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists. The Journal of eukaryotic microbiology, 53 Suppl 1 , S80-4Cushion, Melanie T; Walzer, Peter D; Ashbaugh, Alan; Rebholz, Sandra; Brubaker, Ronald; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L 2006. In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice. Antimicrobial agents and chemotherapy, 50 7, 2337-43Cushion,M.T.; Smulian,A.G. 2006. Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, 53 Suppl 1 , S80Cushion,M.T.; Walzer,P.D.; Ashbaugh,A.; Rebholz,S.; Brubaker,R.; Vanden Eynde,J.J.; Mayence,A.; Huang,T.L. 2006. In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice Antimicrobial Agents and Chemotherapy, 50 7, 2337Dei-Cas, Eduardo; Chabé, Magali; Moukhlis, Raya; Durand-Joly, Isabelle; Aliouat, El Moukhtar; Stringer, James R; Cushion, Melanie; Noël, Christophe; de Hoog, G Sybren; Guillot, Jacques; Viscogliosi, Eric 2006. Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic bases. FEMS microbiology reviews, 30 6, 853-71Icenhour, Crystal R; Arnold, Jonathan; Medvedovic, Mario; Cushion, Melanie T 2006. Competitive coexistence of two Pneumocystis species. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 6 3, 177-86Icenhour,C.R.; Arnold,J.; Medvedovic,M.; Cushion,M.T. 2006. Competitive coexistence of two Pneumocystis species Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 6 3, 177Joffrion, Tiffany M; Collins, Margaret S; Cushion, Melanie T 2006. Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro. The Journal of eukaryotic microbiology, 53 Suppl 1 , S117-8Joffrion,T.M.; Collins,M.S.; Cushion,M.T. 2006. Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro The Journal of eukaryotic microbiology, 53 Suppl 1 , S117Kaneshiro, Edna S; Cali, Ann; Cushion, Melanie T; Lindsay, David S; Marciano-Cabral, Francine; Mead, Jan R; Weiss, Louis M 2006. The International Workshops on Opportunistic Protists. The Journal of eukaryotic microbiology, 53 Suppl 1 , S1-7Redhead,S.A.; Cushion,M.T.; Frenkel,J.K.; Stringer,J.R. 2006. Pneumocystis and Trypanosoma cruzi: nomenclature and typifications The Journal of eukaryotic microbiology, 53 1, 2Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E; Smulian, A George 2006. Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets. The Journal of eukaryotic microbiology, 53 Suppl 1 , S154-5Sesterhenn,T.M.; Cushion,M.T.; Slaven,B.E.; Smulian,A.G. 2006. Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets The Journal of eukaryotic microbiology, 53 Suppl 1 , S154Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S89-91Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S151-3Slaven,B.E.; Meller,J.; Porollo,A.; Sesterhenn,T.; Smulian,A.G.; Cushion,M.T. 2006. Draft assembly and annotation of the Pneumocystis carinii genome The Journal of eukaryotic microbiology, 53 Suppl 1 , S89Slaven,B.E.; Porollo,A.; Sesterhenn,T.; Smulian,A.G.; Cushion,M.T.; Meller,J. 2006. Large-scale characterization of introns in the Pneumocystis carinii genome The Journal of eukaryotic microbiology, 53 Suppl 1 , S151Cushion, Melanie T; Stringer, James R 2005. Has the name really been changed? It has for most researchers. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 12, 1756-8Cushion,M.T.; Stringer,J.R. 2005. Has the name really been changed? It has for most researchers Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 12, 1756Keely, Scott P; Renauld, Hubert; Wakefield, Ann E; Cushion, Melanie T; Smulian, A George; Fosker, Nigel; Fraser, Audrey; Harris, David; Murphy, Lee; Price, Claire; Quail, Michael A; Seeger, Kathy; Sharp, Sarah; Tindal, Carolyn J; Warren, Tim; Zuiderwijk, Eduard; Barrell, Barclay G; Stringer, James R; Hall, Neil 2005. Gene arrays at Pneumocystis carinii telomeres. Genetics, 170 4, 1589-600Keely,S.P.; Renauld,H.; Wakefield,A.E.; Cushion,M.T.; Smulian,A.G.; Fosker,N.; Fraser,A.; Harris,D.; Murphy,L.; Price,C.; Quail,M.A.; Seeger,K.; Sharp,S.; Tindal,C.J.; Warren,T.; Zuiderwijk,E.; Barrell,B.G.; Stringer,J.R.; Hall,N. 2005. Gene arrays at Pneumocystis carinii telomeres Genetics, 170 4, 1589Peterson, J Chad; Cushion, Melanie T 2005. Pneumocystis: not just pneumonia. Current opinion in microbiology, 8 4, 393-8Peterson,J.C.; Cushion,M.T. 2005. Pneumocystis: not just pneumonia Current opinion in microbiology, 8 4, 393Zhang, Jianmin; Tachado, Souvenir D; Patel, Naimish; Zhu, Jinping; Imrich, Amy; Manfruelli, Pascal; Cushion, Melanie; Kinane, T Bernard; Koziel, Henry 2005. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. Journal of leukocyte biology, 78 3, 665-74Zhang, Jianmin; Zhu, Jinping; Bu, Xia; Cushion, Melanie; Kinane, T Bernard; Avraham, Hava; Koziel, Henry 2005. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Molecular biology of the cell, 16 2, 824-34Cushion, Melanie T 2004. Pneumocystis: unraveling the cloak of obscurity. Trends in microbiology, 12 5, 243-9Cushion, Melanie T; Walzer, Peter D; Collins, Margaret S; Rebholz, Sandra; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L 2004. 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Early acquisition of Pneumocystis carinii in neonatal rats as evidenced by PCR and oral swabs Eukaryotic cell, 1 3, 414Zhou, Wenxu; Nguyen, Thi Thuy Minh; Collins, Margaret S; Cushion, Melanie T; Nes, W David 2002. Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. Lipids, 37 12, 1177-86Zhou,W.; Nguyen,T.T.; Collins,M.S.; Cushion,M.T.; Nes,W.D. 2002. Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii Lipids, 37 12, 1177Collins, M S; Cushion, M T 2001. Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations. The Journal of eukaryotic microbiology, Suppl , 178S-179SCollins,M.S.; Cushion,M.T. 2001. Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations The Journal of eukaryotic microbiology, Suppl , 178SCushion, M T; Beck, J M 2001. Summary of Pneumocystis research presented at the 7th International Workshop on Opportunistic Protists. The Journal of eukaryotic microbiology, Suppl , 101S-105SCushion, M T; Orr, S; Keely, S P; Stringer, J R 2001. Time between inoculations and karyotype forms of Pneumocystis carinii f. sp. Carinii influence outcome of experimental coinfections in rats. Infection and immunity, 69 1, 97-107Cushion, M T; Smulian, A G 2001. The pneumocystis genome project: update and issues. The Journal of eukaryotic microbiology, Suppl , 182S-183SCushion,M.T.; Beck,J.M. 2001. Summary of Pneumocystis research presented at the 7th International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, Suppl , 101SCushion,M.T.; Orr,S.; Keely,S.P.; Stringer,J.R. 2001. Time between inoculations and karyotype forms of Pneumocystis carinii f. sp. Carinii influence outcome of experimental coinfections in rats Infection and immunity, 69 1, 97Cushion,M.T.; Smulian,A.G. 2001. 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Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats. Journal of clinical microbiology, 39 12, 4563-5Nahimana,A.; Cushion,M.T.; Blanc,D.S.; Hauser,P.M. 2001. Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats Journal of clinical microbiology, 39 12, 4563Rebholz, S L; Cushion, M T 2001. Three new karyotype forms of Pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (CHEF) electrophoresis. The Journal of eukaryotic microbiology, Suppl , 109S-110SRebholz,S.L.; Cushion,M.T. 2001. 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Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo. The Journal of infectious diseases, 184 10, 1355-7Walzer, P D; Ashbaugh, A; Collins, M; Cushion, M T 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii. Antimicrobial agents and chemotherapy, 45 11, 3234-7Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo The Journal of infectious diseases, 184 10, 1355Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii Antimicrobial Agents and Chemotherapy, 45 11, 3234Cushion, M T; Collins, M; Hazra, B; Kaneshiro, E S 2000. Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. 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The minimum number of Pneumocystis carinii f. sp. carinii organisms required to establish infections is very low The Journal of eukaryotic microbiology, 46 5, 111SIcenhour,C.R.; Arnold,J.; Cushion,M.T. 1999. Interactions of two Pneumocystis carinii populations within rat lungs The Journal of eukaryotic microbiology, 46 5, 107SKaneshiro,E.S.; Collins,M.; Cushion,M.T. 1999. Effects of sterol inhibitors on the ATP content of Pneumocystis carinii The Journal of eukaryotic microbiology, 46 5, 142SKeely,S.P.; Cushion,M.T.; Stringer,J.R. 1999. Determination of the maximum frequency of genetic rearrangements associated with Pneumocystis carinii surface antigen variation The Journal of eukaryotic microbiology, 46 5, 128SPalmer, R J; Cushion, M T; Wakefield, A E 1999. Discrimination of rat-derived Pneumocystis carinii f. sp. Carinii and Pneumocystis carinii f. sp. Ratti using the polymerase chain reaction. 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Evaluation of procedures used to isolate Pneumocystis carinii from infected rat lungs The Journal of eukaryotic microbiology, 41 5, 95SSettnes,O.P.; Nielsen,P.B.; Bucala,R.; Linke,M.J.; Cushion,M.T. 1994. A survey of birds in Denmark for the presence of Pneumocystis carinii Avian Diseases, 38 1, 1Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), 8 11, 1555-62Smulian,A.G.; Linke,M.J.; Cushion,M.T.; Baughman,R.P.; Frame,P.T.; Dohn,M.N.; White,M.L.; Walzer,P.D. 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity AIDS (London, England), 8 11, 1555Vasquez,J.; Smulian,A.G.; Linke,M.J.; Cushion,M.T. 1994. Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 114SWeinberg,G.A.; Dykstra,C.C.; Durant,P.J.; Cushion,M.T. 1994. Chromosomal localization of 20 genes to five distinct pulsed field gel karyotypic forms of rat Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 117SWeinberg,G.A.; O'Gara,M.J.; Cushion,M.T. 1994. Coinfection of rats with genetically diverse forms of Pneumocystis carinii demonstrated by P. carinii inosine monophosphate dehydrogenase gene polymorphism The Journal of eukaryotic microbiology, 41 5, 119SCushion, M T; Kaselis, M; Stringer, S L; Stringer, J R 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infection and immunity, 61 11, 4801-13Cushion, M T; Zhang, J; Kaselis, M; Giuntoli, D; Stringer, S L; Stringer, J R 1993. Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats. Journal of clinical microbiology, 31 5, 1217-23Cushion,M.T.; Kaselis,M.; Stringer,S.L.; Stringer,J.R. 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies Infection and immunity, 61 11, 4801Cushion,M.T.; Zhang,J.; Kaselis,M.; Giuntoli,D.; Stringer,S.L.; Stringer,J.R. 1993. Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats Journal of clinical microbiology, 31 5, 1217Stringer,J.R.; Stringer,S.L.; Zhang,J.; Baughman,R.; Smulian,A.G.; Cushion,M.T. 1993. Molecular genetic distinction of Pneumocystis carinii from rats and humans The Journal of eukaryotic microbiology, 40 6, 733Zhang, J; Cushion, M T; Stringer, J R 1993. Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats. Journal of clinical microbiology, 31 2, 244-8Zhang,J.; Cushion,M.T.; Stringer,J.R. 1993. Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats Journal of clinical microbiology, 31 2, 244De Stefano, J A; Trinkle, L S; Walzer, P D; Cushion, M T 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates. The Journal of parasitology, 78 2, 271-80De Stefano,J.A.; Trinkle,L.S.; Walzer,P.D.; Cushion,M.T. 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates The Journal of parasitology, 78 2, 271Stringer, J R; Edman, J C; Cushion, M T; Richards, F F; Watanabe, J 1992. The fungal nature of Pneumocystis. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 271-8Stringer,J.R.; Edman,J.C.; Cushion,M.T.; Richards,F.F.; Watanabe,J. 1992. The fungal nature of Pneumocystis Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 271Cushion, M T; Stringer, J R; Walzer, P D 1991. Cellular and molecular biology of Pneumocystis carinii. International review of cytology, 131 , 59-107Cushion,M.T.; Linke,M.J. 1991. Factors influencing Pneumocystis infection in the immunocompromised rat The Journal of protozoology, 38 6, 133SCushion,M.T.; Stringer,J.R.; Walzer,P.D. 1991. Cellular and molecular biology of Pneumocystis carinii International review of cytology, 131 , 59Kaneshiro,E.S.; Wu,Y.P.; Cushion,M.T. 1991. Assays for testing Pneumocystis carinii viability The Journal of protozoology, 38 6, 85SZhang,J.X.; Cushion,M.T.; Giuntoli,D.; Hong,S.T.; Meade,J.C.; Smulian,A.G.; Stringer,S.L.; Stringer,J.J. 1991. Analysis of the Pneumocystis carinii genome The Journal of protozoology, 38 6, 69SCushion, M T; Ebbets, D 1990. Growth and metabolism of Pneumocystis carinii in axenic culture. Journal of clinical microbiology, 28 6, 1385-94Cushion, M T; Hong, S T; Steele, P E; Stringer, S L; Walzer, P D; Stringer, J R 1990. Molecular biology of Pneumocystis carinii. Annals of the New York Academy of Sciences, 616 , 415-20Cushion,M.T.; Ebbets,D. 1990. Growth and metabolism of Pneumocystis carinii in axenic culture Journal of clinical microbiology, 28 6, 1385Cushion,M.T.; Hong,S.T.; Steele,P.E.; Stringer,S.L.; Walzer,P.D.; Stringer,J.R. 1990. Molecular biology of Pneumocystis carinii Annals of the New York Academy of Sciences, 616 , 415De Stefano,J.A.; Cushion,M.T.; Puvanesarajah,V.; Walzer,P.D. 1990. Analysis of Pneumocystis carinii cyst wall. II. Sugar composition The Journal of protozoology, 37 5, 436De Stefano,J.A.; Cushion,M.T.; Sleight,R.G.; Walzer,P.D. 1990. Analysis of Pneumocystis carinii cyst wall. I. Evidence for an outer surface membrane The Journal of protozoology, 37 5, 428Hong, S T; Steele, P E; Cushion, M T; Walzer, P D; Stringer, S L; Stringer, J R 1990. Pneumocystis carinii karyotypes. Journal of clinical microbiology, 28 8, 1785-95Hong,S.T.; Steele,P.E.; Cushion,M.T.; Walzer,P.D.; Stringer,S.L.; Stringer,J.R. 1990. Pneumocystis carinii karyotypes Journal of clinical microbiology, 28 8, 1785Cushion,M.T. 1989. In vitro studies of Pneumocystis carinii The Journal of protozoology, 36 1, 45Cushion,M.T.; Blase,M.A.; Walzer,P.D. 1989. A method for isolation of RNA from Pneumocystis carinii The Journal of protozoology, 36 1, 12SDe Stefano,J.A.; Cushion,M.T.; Trinkle,L.S.; Walzer,P.D. 1989. Lectins as probes to Pneumocystis carinii surface glycocomplexes The Journal of protozoology, 36 1, 65SKaneshiro,E.S.; Cushion,M.T.; Walzer,P.D.; Jayasimhulu,K. 1989. Analyses of Pneumocystis fatty acids The Journal of protozoology, 36 1, 69SLinke, M J; Cushion, M T; Walzer, P D 1989. Properties of the major antigens of rat and human Pneumocystis carinii. Infection and immunity, 57 5, 1547-55Linke,M.J.; Cushion,M.T.; Walzer,P.D. 1989. Properties of the major antigens of rat and human Pneumocystis carinii Infection and immunity, 57 5, 1547Ruffolo,J.J.; Cushion,M.T.; Walzer,P.D. 1989. Ultrastructural observations on life cycle stages of Pneumocystis carinii The Journal of protozoology, 36 1, 53SStringer, S L; Stringer, J R; Blase, M A; Walzer, P D; Cushion, M T 1989. Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi. Experimental parasitology, 68 4, 450-61Stringer,S.L.; Hudson,K.; Blase,M.A.; Walzer,P.D.; Cushion,M.T.; Stringer,J.R. 1989. Sequence from ribosomal RNA of Pneumocystis carinii compared to those of four fungi suggests an ascomycetous affinity The Journal of protozoology, 36 1, 14SStringer,S.L.; Stringer,J.R.; Blase,M.A.; Walzer,P.D.; Cushion,M.T. 1989. Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi Experimental parasitology, 68 4, 450Walzer, P D; Cushion, M T 1989. Immunobiology of Pneumocystis carinii. Pathology and immunopathology research, 8 3-4, 127-40Walzer,P.D.; Cushion,M.T. 1989. Immunobiology of Pneumocystis carinii Pathology and immunopathology research, 8 3-4, 127Cushion, M T; DeStefano, J A; Walzer, P D 1988. Pneumocystis carinii: surface reactive carbohydrates detected by lectin probes. Experimental parasitology, 67 2, 137-47Cushion, M T; Ruffolo, J J; Walzer, P D 1988. Analysis of the developmental stages of Pneumocystis carinii, in vitro. Laboratory investigation; a journal of technical methods and pathology, 58 3, 324-31Cushion,M.T.; DeStefano,J.A.; Walzer,P.D. 1988. Pneumocystis carinii: surface reactive carbohydrates detected by lectin probes Experimental parasitology, 67 2, 137Cushion,M.T.; Ruffolo,J.J.; Walzer,P.D. 1988. Analysis of the developmental stages of Pneumocystis carinii, in vitro Laboratory investigation; a journal of technical methods and pathology, 58 3, 324Walzer, P D; Kim, C K; Foy, J M; Linke, M J; Cushion, M T 1988. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, 32 1, 96-103Walzer, P D; Kim, C K; Foy, J; Linke, M J; Cushion, M T 1988. Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, 32 6, 896-905Walzer,P.D.; Kim,C.K.; Foy,J.; Linke,M.J.; Cushion,M.T. 1988. Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia Antimicrobial Agents and Chemotherapy, 32 6, 896Walzer,P.D.; Kim,C.K.; Foy,J.M.; Linke,M.J.; Cushion,M.T. 1988. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia Antimicrobial Agents and Chemotherapy, 32 1, 96Kim, C K; Foy, J M; Cushion, M T; Stanforth, D; Linke, M J; Hendrix, H L; Walzer, P D 1987. Comparison of histologic and quantitative techniques in evaluation of therapy for experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, 31 2, 197-201Kim,C.K.; Foy,J.M.; Cushion,M.T.; Stanforth,D.; Linke,M.J.; Hendrix,H.L.; Walzer,P.D. 1987. Comparison of histologic and quantitative techniques in evaluation of therapy for experimental Pneumocystis carinii pneumonia Antimicrobial Agents and Chemotherapy, 31 2, 197Walzer, P D; Cushion, M T; Juranek, D; Walls, K; Armstrong, D; Gold, J; Young, L S; Pesanti, E; Graves, D C; Ivey, M B 1987. Serology and P carinii. Chest, 91 6, 935-6Walzer, P D; Stanforth, D; Linke, M J; Cushion, M T 1987. Pneumocystis carinii: immunoblotting and immunofluorescent analyses of serum antibodies during experimental rat infection and recovery. Experimental parasitology, 63 3, 319-28Walzer,P.D.; Cushion,M.T.; Juranek,D.; Walls,K.; Armstrong,D.; Gold,J.; Young,L.S.; Pesanti,E.; Graves,D.C.; Ivey,M.B. 1987. Serology and P carinii Chest, 91 6, 935Walzer,P.D.; Stanforth,D.; Linke,M.J.; Cushion,M.T. 1987. Pneumocystis carinii: immunoblotting and immunofluorescent analyses of serum antibodies during experimental rat infection and recovery Experimental parasitology, 63 3, 319Ruffolo, J J; Cushion, M T; Walzer, P D 1986. Techniques for examining Pneumocystis carinii in fresh specimens. Journal of clinical microbiology, 23 1, 17-21Ruffolo,J.J.; Cushion,M.T.; Walzer,P.D. 1986. Techniques for examining Pneumocystis carinii in fresh specimens Journal of clinical microbiology, 23 1, 17Cushion, M T; Ruffolo, J J; Linke, M J; Walzer, P D 1985. Pneumocystis carinii: growth variables and estimates in the A549 and WI-38 VA13 human cell lines. Experimental parasitology, 60 1, 43-54Cushion, M T; Stanforth, D; Linke, M J; Walzer, P D 1985. Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro. Antimicrobial agents and chemotherapy, 28 6, 796-801Cushion,M.T.; Ruffolo,J.J.; Linke,M.J.; Walzer,P.D. 1985. Pneumocystis carinii: growth variables and estimates in the A549 and WI-38 VA13 human cell lines Experimental parasitology, 60 1, 43Cushion,M.T.; Stanforth,D.; Linke,M.J.; Walzer,P.D. 1985. Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro Antimicrobial Agents and Chemotherapy, 28 6, 796Cushion, M T; Walzer, P D 1984. Growth and serial passage of Pneumocystis carinii in the A549 cell line. Infection and immunity, 44 2, 245-51Cushion, M T; Walzer, P D 1984. Cultivation of Pneumocystis carinii in lung-derived cell lines. The Journal of infectious diseases, 149 4, 644Cushion,M.T.; Walzer,P.D. 1984. Growth and serial passage of Pneumocystis carinii in the A549 cell line Infection and immunity, 44 2, 245Cushion,M.T.; Walzer,P.D. 1984. Cultivation of Pneumocystis carinii in lung-derived cell lines The Journal of infectious diseases, 149 4, 644Walzer, P D; LaBine, M; Redington, T J; Cushion, M T 1984. Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts. Infection and immunity, 46 3, 747-53Walzer, P D; LaBine, M; Redington, T J; Cushion, M T 1984. Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia. Journal of immunology (Baltimore, Md. : 1950), 133 5, 2502-8Walzer,P.D.; LaBine,M.; Redington,T.J.; Cushion,M.T. 1984. Predisposing factors in Pneumocystis carinii pneumonia: effects of tetracycline, protein malnutrition, and corticosteroids on hosts Infection and immunity, 46 3, 747Walzer,P.D.; LaBine,M.; Redington,T.J.; Cushion,M.T. 1984. Lymphocyte changes during chronic administration of and withdrawal from corticosteroids: relation to Pneumocystis carinii pneumonia Journal of immunology (Baltimore, Md.: 1950), 133 5, 2502 Gomes A.; Ferraz R.; Ficker L.; Collins M.S.; Prudêncio C.; Cushion M.T.; Teixeira C.; Gomes P. 11-01-2018. Chloroquine analogues as leads against Pneumocystis lung pathogens Antimicrobial Agents and Chemotherapy, 62 11, Luraschi A.; Richard S.; Almeida J.M.; Pagni M.; Cushion M.T.; Hauser P.M. 07-01-2019. Expression and immunostaining analyses suggest that pneumocystis primary homothallism involves troph mBio, 10 4, Maciejewska D.; Zabi?ski J.; Rezler M.; Ka?mierczak P.; Collins M.; Ficker L.; Cushion M. 01-01-2017. Development of highly active anti-: Pneumocystis bisbenzamidines: Insight into the influence of sele MedChemComm, 8 10, 2003-2011Andrews, R P; Theus, S A; Cushion, M T; Walzer, P D . Comparison of the antigenic recognition of the major surface glycoprotein of Pneumocystis carinii isolated from different rat strains. The Journal of eukaryotic microbiology, 41 5, 72SArnold, J; Cushion, M T . Constructing a physical map of the Pneumocystis genome. The Journal of eukaryotic microbiology, 44 6, 8SChen, F; Cushion, M T . Use of fluorescent probes to investigate the metabolic state of Pneumocystis carinii mitochondria. The Journal of eukaryotic microbiology, 41 5, 79SCushion, M T . Summary of the Pneumocystis research presented at the 6th International Workshop on Opportunistic Protists. The Journal of eukaryotic microbiology, 46 5, 85S-88SCushion, M T . In vitro studies of Pneumocystis carinii. The Journal of protozoology, 36 1, 45-52Cushion, M T; Arnold, J . Proposal for a Pneumocystis genome project. The Journal of eukaryotic microbiology, 44 6, 7SCushion, M T; Blase, M A; Walzer, P D . A method for isolation of RNA from Pneumocystis carinii. The Journal of protozoology, 36 1, 12S-14SCushion, M T; Linke, M J . Factors influencing Pneumocystis infection in the immunocompromised rat. The Journal of protozoology, 38 6, 133S-135SCushion, M T; Linke, M J; Collins, M; Keely, S P; Stringer, J R . The minimum number of Pneumocystis carinii f. sp. carinii organisms required to establish infections is very low. The Journal of eukaryotic microbiology, 46 5, 111SCushion, M T; Orr, S . Kinetics of 2 genetically distinct Pneumocystis carinii populations in rat colonies. The Journal of eukaryotic microbiology, 43 5, 46SCushion, M T; Orr, S; Arnold, J . Interactions between 2 Pneumocystis populations within the same host. The Journal of eukaryotic microbiology, 44 6, 9SCushion, M T; Walzer, P D . Closing comments: a retrospective perspective 4th International Workshop on Pneumocystis. The Journal of eukaryotic microbiology, 43 5, 60S-61SCushion, Melanie T . Comparative genomics of Pneumocystis carinii with other protists: implications for life style. The Journal of eukaryotic microbiology, 51 1, 30-7Cushion, Melanie T; Keely, Scott P; Stringer, James R . Molecular and phenotypic description of Pneumocystis wakefieldiae sp. nov., a new species in rats. Mycologia, 96 3, 429-38De Stefano, J A; Cushion, M T; Puvanesarajah, V; Walzer, P D . Analysis of Pneumocystis carinii cyst wall. II. Sugar composition. The Journal of protozoology, 37 5, 436-41De Stefano, J A; Cushion, M T; Sleight, R G; Walzer, P D . Analysis of Pneumocystis carinii cyst wall. I. Evidence for an outer surface membrane. The Journal of protozoology, 37 5, 428-35De Stefano, J A; Cushion, M T; Trinkle, L S; Walzer, P D . Lectins as probes to Pneumocystis carinii surface glycocomplexes. The Journal of protozoology, 36 1, 65S-66SIcenhour, C R; Arnold, J; Cushion, M T . Interactions of two Pneumocystis carinii populations within rat lungs. The Journal of eukaryotic microbiology, 46 5, 107S-108SKaneshiro, E S; Collins, M; Cushion, M T . Effects of sterol inhibitors on the ATP content of Pneumocystis carinii. The Journal of eukaryotic microbiology, 46 5, 142S-143SKaneshiro, E S; Cushion, M T; Walzer, P D; Jayasimhulu, K . Analyses of Pneumocystis fatty acids. The Journal of protozoology, 36 1, 69S-72SKaneshiro, E S; Wu, Y P; Cushion, M T . Assays for testing Pneumocystis carinii viability. The Journal of protozoology, 38 6, 85S-87SKaneshiro, Edna S; Cushion, Melanie T; Marciano-Cabral, Francine; Weiss, Louis M; Xiao, Lihua . Highlights and summaries of the 11th International Workshops on Opportunistic Protists. The Journal of eukaryotic microbiology, 58 1, 1-6Keely, S P; Cushion, M T; Stringer, J R . Determination of the maximum frequency of genetic rearrangements associated with Pneumocystis carinii surface antigen variation. The Journal of eukaryotic microbiology, 46 5, 128SKeely, S P; Cushion, M T; Stringer, J R . Stability of four genetic loci in Pneumocystis carinii sp. f. carinii. The Journal of eukaryotic microbiology, 43 5, 49SLangreth, S G; Kim, G M; Cushion, M T . Evaluation of procedures used to isolate Pneumocystis carinii from infected rat lungs. The Journal of eukaryotic microbiology, 41 5, 95S-96SRedhead, Scott A; Cushion, Melanie T; Frenkel, Jacob K; Stringer, James R . Pneumocystis and Trypanosoma cruzi: nomenclature and typifications. The Journal of eukaryotic microbiology, 53 1, 2-11Ruffolo, J J; Cushion, M T; Walzer, P D . Ultrastructural observations on life cycle stages of Pneumocystis carinii. The Journal of protozoology, 36 1, 53S-54SSettnes, O P; Nielsen, P B; Bucala, R; Linke, M J; Cushion, M T . A survey of birds in Denmark for the presence of Pneumocystis carinii. Avian diseases, 38 1, 1-10Sloand, E; Laughon, B; Armstrong, M; Bartlett, M S; Blumenfeld, W; Cushion, M; Kalica, A; Kovacs, J A; Martin, W; Pitt, E . The challenge of Pneumocystis carinii culture. The Journal of eukaryotic microbiology, 40 2, 188-95Stringer, J R; Stringer, S L; Zhang, J; Baughman, R; Smulian, A G; Cushion, M T . Molecular genetic distinction of Pneumocystis carinii from rats and humans. The Journal of eukaryotic microbiology, 40 6, 733-41Stringer, J R; Wakefield, A E; Cushion, M T; Dei-Cas, E . Pneumocystis taxonomy and nomenclature: an update. The Journal of eukaryotic microbiology, 44 6, 5S-6SStringer, S L; Hudson, K; Blase, M A; Walzer, P D; Cushion, M T; Stringer, J R . Sequence from ribosomal RNA of Pneumocystis carinii compared to those of four fungi suggests an ascomycetous affinity. The Journal of protozoology, 36 1, 14S-16SVasquez, J; Smulian, A G; Linke, M J; Cushion, M T . Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii. The Journal of eukaryotic microbiology, 41 5, 114SWeinberg, G A; Dykstra, C C; Durant, P J; Cushion, M T . Chromosomal localization of 20 genes to five distinct pulsed field gel karyotypic forms of rat Pneumocystis carinii. The Journal of eukaryotic microbiology, 41 5, 117SWeinberg, G A; O'Gara, M J; Cushion, M T . Coinfection of rats with genetically diverse forms of Pneumocystis carinii demonstrated by P. carinii inosine monophosphate dehydrogenase gene polymorphism. The Journal of eukaryotic microbiology, 41 5, 119SZhang, J X; Cushion, M T; Giuntoli, D; Hong, S T; Meade, J C; Smulian, A G; Stringer, S L; Stringer, J J . Analysis of the Pneumocystis carinii genome. The Journal of protozoology, 38 6, 69S
Research InterestsFungi in the genus Pneumocystis cause an oftentimes lethal pneumonia (PCP) in humans and other mammals with compromised immune status. The niche of these fungi include patients with underlying chronic diseases such as COPD or HIV and those receiving anti-inflammatory or immunosuppressive agents. PCP is not responsive to standard antifungal therapy with few treatment alternatives besides trimethoprim-sulfamethoxazole. My laboratory focuses on pre-clinical drug development that inc...
Peer Reviewed Publications Cissé, Ousmane H; Curran, Shelly J; Folco, H Diego; Liu, Yueqin; Bishop, Lisa; Wang, Honghui; Fischer, Elizabeth R; Davis, A Sally; Combs, Christian; Thapar, Sabrina; Dekker, John P; Grewal, Shiv; Cushion, Melanie; Ma, Liang; Kovacs, Joseph A 2024. Regional centromere configuration in the fungal pathogens of the Pneumocystis genus. mBio, , e0318523Sayson, Steven G; Ashbaugh, Alan; Cushion, Melanie T 2024. Extracellular vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions. Microbiology spectrum, 12 2, e0365323Sayson, Steven G; Ashbaugh, Alan; Porollo, Aleksey; Cushion, Melanie T 2024. Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia. bioRxiv : the preprint server for biology, , Cissé, Ousmane H; Curran, Shelly; Folco, H Diego; Liu, Yueqin; Bishop, Lisa; Wang, Honghui; Fischer, Elizabeth R; Davis, A Sally; Babb-Biernacki, Spenser; Doyle, Vinson P; Richards, Jonathan K; Hassan, Sergio A; Dekker, John P; Khil, Pavel P; Brenchley, Jason M; Grewal, Shiv; Cushion, Melanie; Ma, Liang; Kovacs, Joseph A 2023. The Host Adapted Fungal Pathogens of Pneumocystis Genus Utilize Genic Regional Centromeres. bioRxiv : the preprint server for biology, , Meier, Caroline S; Pagni, Marco; Richard, Sophie; Mühlethaler, Konrad; Almeida, João M G C F; Nevez, Gilles; Cushion, Melanie T; Calderón, Enrique J; Hauser, Philippe M 2023. Publisher Correction: Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 1, 7928Meier, Caroline S; Pagni, Marco; Richard, Sophie; Mühlethaler, Konrad; Almeida, João M G C F; Nevez, Gilles; Cushion, Melanie T; Calderón, Enrique J; Hauser, Philippe M 2023. Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes' repertoires. Nature communications, 14 1, 7026Sayson, Steven G; Ashbaugh, Alan; Cushion, Melanie T 2023. Extracellular Vesicles from Pneumocystis carinii -Infected Rats Impair Fungal Viability but are Dispensable for Macrophage Functions. bioRxiv : the preprint server for biology, , Wiederhold, Nathan P; Patterson, Thomas F; Rebholz, Sandra; Brennan, James; Patton, Thomas; Barrett, John; Boal, Connell W C; Ehrensberger, Monika; Boyle, Ryan; Cushion, Melanie T 2023. Erratum for Wiederhold et al., "The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate)". Antimicrobial agents and chemotherapy, 67 2, e0147522Cushion, Melanie T; Ashbaugh, Alan; Sayson, Steven G; Mosley, Christopher; Hauser, Philippe M 2022. Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication. Microbiology spectrum, 10 6, e0290622Macioce-Tisdale, Nikeya L; Ashbaugh, Alan; Hendrix, Keeley; Collins, Margaret S; Porollo, Aleksey; Cushion, Melanie T 2022. The Effects of Sex and Strain on Pneumocystis murina Fungal Burdens in Mice. Journal of fungi (Basel, Switzerland), 8 10, Wiederhold, Nathan P; Patterson, Thomas F; Rebholz, Sandra; Boal, Connell W C; Ehrensberger, Monika; Boyle, Ryan; Cushion, Melanie T 2022. The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate). Antimicrobial agents and chemotherapy, 66 8, e0052122Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. Genomic insights into the host specific adaptation of the Pneumocystis genus. Communications biology, 4 1, 305Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. Genomic insights into the host specific adaptation of the Pneumocystis genus. Communications biology, 4 1, 305Cushion, Melanie T; Ashbaugh, Alan 2021. The Long-Acting Echinocandin, Rezafungin, Prevents Pneumocystis Pneumonia and Eliminates Pneumocystis from the Lungs in Prophylaxis and Murine Treatment Models. Journal of fungi (Basel, Switzerland), 7 9, Cushion, Melanie T; Tisdale-Macioce, Nikeya; Sayson, Steven G; Porollo, Aleksey 2021. The Persistent Challenge of Pneumocystis Growth Outside the Mammalian Lung: Past and Future Approaches. Frontiers in microbiology, 12 , 681474Miesel, Lynn; Cushion, Melanie T; Ashbaugh, Alan; Lopez, Santiago R; Ong, Voon 2021. Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia. Antimicrobial agents and chemotherapy, 65 3, Tisdale-Macioce, Nikeya; Green, Jenna; Perl, Anne-Karina T; Ashbaugh, Alan; Wiederhold, Nathan P; Patterson, Thomas F; Cushion, Melanie T 2021. The Promise of Lung Organoids for Growth and Investigation of Pneumocystis Species. Frontiers in fungal biology, 2 , 740845Cushion, Melanie T; Kumar, Parag; Lu, Ruying; Ashbaugh, Alan; Adeojo, Lilian W; Alfaro, Raul; Mannino, Raphael; Tramont, Edmund; Kovacs, Joseph A 2020. A Novel Encochleated Formulation Improves Atovaquone Activity in a Murine Model of Pneumocystis Pneumonia. The Journal of infectious diseases, , Ma, Liang; Chen, Zehua; Huang, Da Wei; Cissé, Ousmane H; Rothenburger, Jamie L; Latinne, Alice; Bishop, Lisa; Blair, Robert; Brenchley, Jason M; Chabé, Magali; Deng, Xilong; Hirsch, Vanessa; Keesler, Rebekah; Kutty, Geetha; Liu, Yueqin; Margolis, Daniel; Morand, Serge; Pahar, Bapi; Peng, Li; Van Rompay, Koen K A; Song, Xiaohong; Song, Jun; Sukura, Antti; Thapar, Sabrina; Wang, Honghui; Weissenbacher-Lang, Christiane; Xu, Jie; Lee, Chao-Hung; Jardine, Claire; Lempicki, Richard A; Cushion, Melanie T; Cuomo, Christina A; Kovacs, Joseph A 2020. Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple Pneumocystis Species. mBio, 11 2, Liu, Guan-Sheng; Ballweg, Richard; Ashbaugh, Alan; Zhang, Yin; Facciolo, Joseph; Cushion, Melanie T; Zhang, Tongli 2019. Correction to: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC systems biology, 13 1, 40Luraschi, A; Richard, S; Almeida, J M G C F; Pagni, M; Cushion, M T; Hauser, P M 2019. Expression and Immunostaining Analyses Suggest that Pneumocystis Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors. mBio, 10 4, Cushion, Melanie T 2018. Reply to Nevez et al., "The Fascinating Echinocandin-Treated Mouse Model of Pneumocystis murina To Understand Pneumocystis jirovecii". Antimicrobial agents and chemotherapy, 62 8, Cushion, Melanie T; Ashbaugh, Alan; Hendrix, Keeley; Linke, Michael J; Tisdale, Nikeya; Sayson, Steven G; Porollo, Aleksey 2018. Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation. Antimicrobial agents and chemotherapy, 62 5, Cushion, Melanie T; Limper, Andrew H; Porollo, Aleksey; Saper, Vivian E; Sinai, Anthony P; Weiss, Louis M 2018. The 14th International Workshops on Opportunistic Protists (IWOP 14). The Journal of eukaryotic microbiology, 65 6, 934-939Gomes, Ana; Ferraz, Ricardo; Ficker, Lauren; Collins, Margaret S; Prudêncio, Cristina; Cushion, Melanie T; Teixeira, Cátia; Gomes, Paula 2018. Chloroquine Analogues as Leads against Pneumocystis Lung Pathogens. Antimicrobial agents and chemotherapy, 62 11, Hauser, Philippe M; Cushion, Melanie T 2018. Is sex necessary for the proliferation and transmission of Pneumocystis? PLoS pathogens, 14 12, e1007409Lazzarini, Cristina; Haranahalli, Krupanandan; Rieger, Robert; Ananthula, Hari Krishna; Desai, Pankaj B; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie T; Ruzsicska, Bela; Haley, John; Ojima, Iwao; Del Poeta, Maurizio 2018. Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids. Antimicrobial agents and chemotherapy, 62 5, Liu, Guan-Sheng; Ballweg, Richard; Ashbaugh, Alan; Zhang, Yin; Facciolo, Joseph; Cushion, Melanie T; Zhang, Tongli 2018. A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC systems biology, 12 1, 77Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio 2018. Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids". mBio, 9 2, Maciejewska, D; Zabinski, J; Rezler, M; Kazmierczak, P; Collins, M S; Ficker, L; Cushion, M T 2017. Correction: Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 11, 2164Maciejewska, D; Zabinski, J; Rezler, M; Kazmierczak, P; Collins, M S; Ficker, L; Cushion, M T 2017. Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 10, 2003-2011Baker, Frazier N; Cushion, Melanie T; Porollo, Aleksey 2016. A Quantitative Model to Estimate Drug Resistance in Pathogens. Journal of fungi (Basel, Switzerland), 2 4, Cushion, Melanie T; Collins, Margaret S; Sesterhenn, Thomas; Porollo, Aleksey; Vadukoot, Anish Kizhakkekkara; Merino, Edward J 2016. Functional Characterization of Pneumocystis carinii Inositol Transporter 1. mBio, 7 6, Koselny, Kristy; Green, Julianne; DiDone, Louis; Halterman, Justin P; Fothergill, Annette W; Wiederhold, Nathan P; Patterson, Thomas F; Cushion, Melanie T; Rappelye, Chad; Wellington, Melanie; Krysan, Damian J 2016. The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis. Antimicrobial agents and chemotherapy, 60 12, 7115-7127Calderon, Enrique J; Cushion, Melanie T; Xiao, Lihua; Lorenzo-Morales, Jacob; Matos, Olga; Kaneshiro, Edna S; Weiss, Louis M 2015. The 13th International Workshops on Opportunistic Protists (IWOP13). The Journal of eukaryotic microbiology, 62 5, 701-9Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio 2015. Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids. mBio, 6 3, e00647Porollo, Aleksey; Sesterhenn, Thomas M; Collins, Margaret S; Welge, Jeffrey A; Cushion, Melanie T 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. mBio, 5 6, e01834Cushion, Melanie T; Keely, Scott P 2013. Assembly and annotation of Pneumocystis jirovecii from the human lung microbiome. mBio, 4 2, e00224Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T 2013. Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infection and immunity, 81 3, 984-95Lobo, Maria Luísa; Esteves, Francisco; de Sousa, Bruno; Cardoso, Fernando; Cushion, Melanie T; Antunes, Francisco; Matos, Olga 2013. Therapeutic potential of caspofungin combined with trimethoprim-sulfamethoxazole for pneumocystis pneumonia: a pilot study in mice. PloS one, 8 8, e70619Weiss, Louis M; Cushion, Melanie T; Didier, Elizabeth; Xiao, Lihua; Marciano-Cabral, Francine; Sinai, Anthony P; Matos, Olga; Calderon, Enrique J; Kaneshiro, Edna S 2013. The 12th International Workshops on Opportunistic Protists (IWOP-12). The Journal of eukaryotic microbiology, 60 3, 298-308Maciejewska, Dorota; Zabinski, Jerzy; Ka?mierczak, Pawel; Rezler, Mateusz; Krassowska-?wiebocka, Barbara; Collins, Margaret S; Cushion, Melanie T 2012. Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics. European journal of medicinal chemistry, 48 , 164-73Porollo, Aleksey; Meller, Jaroslaw; Joshi, Yogesh; Jaiswal, Vikash; Smulian, A George; Cushion, Melanie T 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current drug targets, 13 12, 1575-85Sinai, Anthony P; Kaneshiro, Edna S; Ward, Honorine; Weiss, Louis M; Cushion, Melanie T 2012. The state of research for AIDS-associated opportunistic infections and the importance of sustaining smaller research communities. Eukaryotic cell, 11 2, 90-7Cushion, Melanie T; Collins, Margaret S 2011. Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures. Antimicrobial agents and chemotherapy, 55 10, 4513-8Cushion, Melanie T 2010. Are members of the fungal genus pneumocystis (a) commensals; (b) opportunists; (c) pathogens; or (d) all of the above? PLoS pathogens, 6 9, Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D 2010. Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PloS one, 5 1, e8524Cushion, Melanie T; Stringer, James R 2010. Stealth and opportunism: alternative lifestyles of species in the fungal genus Pneumocystis. Annual review of microbiology, 64 , 431-52Joffrion, Tiffany M; Collins, Margaret S; Sesterhenn, Thomas; Cushion, Melanie T 2010. Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryotic cell, 9 1, 107-15Joffrion, Tiffany M; Cushion, Melanie T 2010. Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii. FEMS microbiology letters, 311 1, 1-9Sesterhenn, Thomas M; Slaven, Bradley E; Keely, Scott P; Smulian, A George; Lang, B Franz; Cushion, Melanie T 2010. Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii. Molecular genetics and genomics : MGG, 283 1, 63-72Beck, James M; Cushion, Melanie T 2009. Pneumocystis workshop: 10th anniversary summary. Eukaryotic cell, 8 4, 446-60Brubaker, R; Redhead, S A; Stringer, J R; Keely, S P; Cushion, M T 2009. Misinformation about Pneumocystis. Clinical and experimental dermatology, 34 7, e426-7Cushion, Melanie T; Collins, Margaret S; Linke, Michael J 2009. Biofilm formation by Pneumocystis spp. Eukaryotic cell, 8 2, 197-206Cushion, Melanie T; Walzer, Peter D 2009. Preclinical drug discovery for new anti-pneumocystis compounds. Current medicinal chemistry, 16 20, 2514-30Huang, Tien L; Vanden Eynde, Jean Jacques; Mayence, Annie; Collins, Margaret S; Cushion, Melanie T; Rattendi, Donna; Londono, Indira; Mazumder, Lakshman; Bacchi, Cyrus J; Yarlett, Nigel 2009. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorganic & medicinal chemistry letters, 19 20, 5884-6Liu, Yu; Leigh, Jessica W; Brinkmann, Henner; Cushion, Melanie T; Rodriguez-Ezpeleta, Naiara; Philippe, Hervé; Lang, B Franz 2009. Phylogenomic analyses support the monophyly of Taphrinomycotina, including Schizosaccharomyces fission yeasts. Molecular biology and evolution, 26 1, 27-34Vale, Nuno; Prudêncio, Miguel; Marques, Catarina A; Collins, Margaret S; Gut, Jiri; Nogueira, Fátima; Matos, Joana; Rosenthal, Philip J; Cushion, Melanie T; do Rosário, Virgílio E; Mota, Maria M; Moreira, Rui; Gomes, Paula 2009. Imidazoquines as antimalarial and antipneumocystis agents. Journal of medicinal chemistry, 52 23, 7800-7Mayence, Annie; Pietka, Aurélie; Collins, Margaret S; Cushion, Melanie T; Tekwani, Babu L; Huang, Tien L; Vanden Eynde, Jean Jacques 2008. Novel bisbenzimidazoles with antileishmanial effectiveness. Bioorganic & medicinal chemistry letters, 18 8, 2658-61Vale, Nuno; Collins, Margaret S; Gut, Jiri; Ferraz, Ricardo; Rosenthal, Philip J; Cushion, Melanie T; Moreira, Rui; Gomes, Paula 2008. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. 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In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice. Antimicrobial agents and chemotherapy, 50 7, 2337-43Cushion,M.T.; Smulian,A.G. 2006. Pneumocystis 2006: summary of the research presented at the ninth International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, 53 Suppl 1 , S80Cushion,M.T.; Walzer,P.D.; Ashbaugh,A.; Rebholz,S.; Brubaker,R.; Vanden Eynde,J.J.; Mayence,A.; Huang,T.L. 2006. In vitro selection and in vivo efficacy of piperazine- and alkanediamide-linked bisbenzamidines against Pneumocystis pneumonia in mice Antimicrobial Agents and Chemotherapy, 50 7, 2337Dei-Cas, Eduardo; Chabé, Magali; Moukhlis, Raya; Durand-Joly, Isabelle; Aliouat, El Moukhtar; Stringer, James R; Cushion, Melanie; Noël, Christophe; de Hoog, G Sybren; Guillot, Jacques; Viscogliosi, Eric 2006. Pneumocystis oryctolagi sp. nov., an uncultured fungus causing pneumonia in rabbits at weaning: review of current knowledge, and description of a new taxon on genotypic, phylogenetic and phenotypic bases. FEMS microbiology reviews, 30 6, 853-71Icenhour, Crystal R; Arnold, Jonathan; Medvedovic, Mario; Cushion, Melanie T 2006. Competitive coexistence of two Pneumocystis species. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 6 3, 177-86Icenhour,C.R.; Arnold,J.; Medvedovic,M.; Cushion,M.T. 2006. Competitive coexistence of two Pneumocystis species Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 6 3, 177Joffrion, Tiffany M; Collins, Margaret S; Cushion, Melanie T 2006. Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro. The Journal of eukaryotic microbiology, 53 Suppl 1 , S117-8Joffrion,T.M.; Collins,M.S.; Cushion,M.T. 2006. Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro The Journal of eukaryotic microbiology, 53 Suppl 1 , S117Kaneshiro, Edna S; Cali, Ann; Cushion, Melanie T; Lindsay, David S; Marciano-Cabral, Francine; Mead, Jan R; Weiss, Louis M 2006. The International Workshops on Opportunistic Protists. The Journal of eukaryotic microbiology, 53 Suppl 1 , S1-7Redhead,S.A.; Cushion,M.T.; Frenkel,J.K.; Stringer,J.R. 2006. Pneumocystis and Trypanosoma cruzi: nomenclature and typifications The Journal of eukaryotic microbiology, 53 1, 2Sesterhenn, Thomas M; Cushion, Melanie T; Slaven, Bradley E; Smulian, A George 2006. Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets. The Journal of eukaryotic microbiology, 53 Suppl 1 , S154-5Sesterhenn,T.M.; Cushion,M.T.; Slaven,B.E.; Smulian,A.G. 2006. Sequence of the mitochondrial genome of Pneumocystis carinii: implications for biological function and identification of potential drug targets The Journal of eukaryotic microbiology, 53 Suppl 1 , S154Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S89-91Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S151-3Slaven,B.E.; Meller,J.; Porollo,A.; Sesterhenn,T.; Smulian,A.G.; Cushion,M.T. 2006. Draft assembly and annotation of the Pneumocystis carinii genome The Journal of eukaryotic microbiology, 53 Suppl 1 , S89Slaven,B.E.; Porollo,A.; Sesterhenn,T.; Smulian,A.G.; Cushion,M.T.; Meller,J. 2006. Large-scale characterization of introns in the Pneumocystis carinii genome The Journal of eukaryotic microbiology, 53 Suppl 1 , S151Cushion, Melanie T; Stringer, James R 2005. Has the name really been changed? It has for most researchers. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 12, 1756-8Cushion,M.T.; Stringer,J.R. 2005. Has the name really been changed? It has for most researchers Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 41 12, 1756Keely, Scott P; Renauld, Hubert; Wakefield, Ann E; Cushion, Melanie T; Smulian, A George; Fosker, Nigel; Fraser, Audrey; Harris, David; Murphy, Lee; Price, Claire; Quail, Michael A; Seeger, Kathy; Sharp, Sarah; Tindal, Carolyn J; Warren, Tim; Zuiderwijk, Eduard; Barrell, Barclay G; Stringer, James R; Hall, Neil 2005. Gene arrays at Pneumocystis carinii telomeres. Genetics, 170 4, 1589-600Keely,S.P.; Renauld,H.; Wakefield,A.E.; Cushion,M.T.; Smulian,A.G.; Fosker,N.; Fraser,A.; Harris,D.; Murphy,L.; Price,C.; Quail,M.A.; Seeger,K.; Sharp,S.; Tindal,C.J.; Warren,T.; Zuiderwijk,E.; Barrell,B.G.; Stringer,J.R.; Hall,N. 2005. Gene arrays at Pneumocystis carinii telomeres Genetics, 170 4, 1589Peterson, J Chad; Cushion, Melanie T 2005. Pneumocystis: not just pneumonia. Current opinion in microbiology, 8 4, 393-8Peterson,J.C.; Cushion,M.T. 2005. Pneumocystis: not just pneumonia Current opinion in microbiology, 8 4, 393Zhang, Jianmin; Tachado, Souvenir D; Patel, Naimish; Zhu, Jinping; Imrich, Amy; Manfruelli, Pascal; Cushion, Melanie; Kinane, T Bernard; Koziel, Henry 2005. Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro. Journal of leukocyte biology, 78 3, 665-74Zhang, Jianmin; Zhu, Jinping; Bu, Xia; Cushion, Melanie; Kinane, T Bernard; Avraham, Hava; Koziel, Henry 2005. Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. Molecular biology of the cell, 16 2, 824-34Cushion, Melanie T 2004. Pneumocystis: unraveling the cloak of obscurity. Trends in microbiology, 12 5, 243-9Cushion, Melanie T; Walzer, Peter D; Collins, Margaret S; Rebholz, Sandra; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L 2004. Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds. Antimicrobial agents and chemotherapy, 48 11, 4209-16Cushion,M.T. 2004. Pneumocystis: unraveling the cloak of obscurity Trends in microbiology, 12 5, 243Cushion,M.T. 2004. Comparative genomics of Pneumocystis carinii with other protists: implications for life style The Journal of eukaryotic microbiology, 51 1, 30Cushion,M.T.; Walzer,P.D.; Collins,M.S.; Rebholz,S.; Vanden Eynde,J.J.; Mayence,A.; Huang,T.L. 2004. Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds Antimicrobial Agents and Chemotherapy, 48 11, 4209Keely, Scott P; Fischer, Jared M; Cushion, Melanie T; Stringer, James R 2004. Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice. Microbiology (Reading, England), 150 Pt 5, 1153-65Keely,S.P.; Fischer,J.M.; Cushion,M.T.; Stringer,J.R. 2004. Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice Microbiology (Reading, England), 150 Pt 5, 1153Mayence, Annie; Vanden Eynde, Jean Jacques; Krogstad, Fran M; Krogstad, Donald J; Cushion, Melanie T; Huang, Tien L 2004. Parallel solution-phase synthesis of conformationally restricted congeners of pentamidine and evaluation of their antiplasmodial activities. Journal of medicinal chemistry, 47 10, 2700-5Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L; Collins, Margaret S; Rebholz, Sandra; Walzer, Peter D; Cushion, Melanie T 2004. Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia. Bioorganic & medicinal chemistry letters, 14 17, 4545-8Vanden Eynde,J.J.; Mayence,A.; Huang,T.L.; Collins,M.S.; Rebholz,S.; Walzer,P.D.; Cushion,M.T. 2004. 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Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats. Infection and immunity, 71 1, 47-60Keely,S.P.; Cushion,M.T.; Stringer,J.R. 2003. Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats Infection and immunity, 71 1, 47Linke, Michael J; Rebholz, Sandy; Collins, Margaret; Tanaka, Reiko; Cushion, Melanie T 2003. Noninvasive method for monitoring Pneumocystis carinii pneumonia. Emerging infectious diseases, 9 12, 1613-6Linke,M.J.; Rebholz,S.; Collins,M.; Tanaka,R.; Cushion,M.T. 2003. Noninvasive method for monitoring Pneumocystis carinii pneumonia Emerging infectious diseases, 9 12, 1613Sesterhenn, Thomas M; Slaven, Bradley E; Smulian, A George; Cushion, Melanie T 2003. Generation of sequencing libraries for the Pneumocystis Genome project. The Journal of eukaryotic microbiology, 50 Suppl , 663-5Sesterhenn,T.M.; Slaven,B.E.; Smulian,A.G.; Cushion,M.T. 2003. Generation of sequencing libraries for the Pneumocystis Genome project The Journal of eukaryotic microbiology, 50 Suppl , 663Xu, Zheng; Lance, Britton; Vargas, Claudia; Arpinar, Budak; Bhandarkar, Suchendra; Kraemer, Eileen; Kochut, Krys J; Miller, John A; Wagner, Jeff R; Weise, Michael J; Wunderlich, John K; Stringer, James; Smulian, George; Cushion, Melanie T; Arnold, Jonathan 2003. Mapping by sequencing the Pneumocystis genome using the ordering DNA sequences V3 tool. Genetics, 163 4, 1299-313Xu,Z.; Lance,B.; Vargas,C.; Arpinar,B.; Bhandarkar,S.; Kraemer,E.; Kochut,K.J.; Miller,J.A.; Wagner,J.R.; Weise,M.J.; Wunderlich,J.K.; Stringer,J.; Smulian,G.; Cushion,M.T.; Arnold,J. 2003. 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Early acquisition of Pneumocystis carinii in neonatal rats as evidenced by PCR and oral swabs Eukaryotic cell, 1 3, 414Zhou, Wenxu; Nguyen, Thi Thuy Minh; Collins, Margaret S; Cushion, Melanie T; Nes, W David 2002. Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. Lipids, 37 12, 1177-86Zhou,W.; Nguyen,T.T.; Collins,M.S.; Cushion,M.T.; Nes,W.D. 2002. Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii Lipids, 37 12, 1177Collins, M S; Cushion, M T 2001. Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations. The Journal of eukaryotic microbiology, Suppl , 178S-179SCollins,M.S.; Cushion,M.T. 2001. Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations The Journal of eukaryotic microbiology, Suppl , 178SCushion, M T; Beck, J M 2001. Summary of Pneumocystis research presented at the 7th International Workshop on Opportunistic Protists. The Journal of eukaryotic microbiology, Suppl , 101S-105SCushion, M T; Orr, S; Keely, S P; Stringer, J R 2001. Time between inoculations and karyotype forms of Pneumocystis carinii f. sp. Carinii influence outcome of experimental coinfections in rats. Infection and immunity, 69 1, 97-107Cushion, M T; Smulian, A G 2001. The pneumocystis genome project: update and issues. The Journal of eukaryotic microbiology, Suppl , 182S-183SCushion,M.T.; Beck,J.M. 2001. Summary of Pneumocystis research presented at the 7th International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, Suppl , 101SCushion,M.T.; Orr,S.; Keely,S.P.; Stringer,J.R. 2001. Time between inoculations and karyotype forms of Pneumocystis carinii f. sp. Carinii influence outcome of experimental coinfections in rats Infection and immunity, 69 1, 97Cushion,M.T.; Smulian,A.G. 2001. The pneumocystis genome project: update and issues The Journal of eukaryotic microbiology, Suppl , 182SIcenhour, C R; Cushion, M T 2001. Putative transmissive form of Pneumocystis carinii f. sp. carinii. The Journal of eukaryotic microbiology, Suppl , 139S-140SIcenhour, C R; Rebholz, S L; Collins, M S; Cushion, M T 2001. Widespread occurrence of Pneumocystis carinii in commercial rat colonies detected using targeted PCR and oral swabs. Journal of clinical microbiology, 39 10, 3437-41Icenhour, C R; Rebholz, S L; Collins, M S; Cushion, M T 2001. Early acquisition of Pneumocystis carinii in neonatal rats using targeted PCR and oral swabs. The Journal of eukaryotic microbiology, Suppl , 135S-136SIcenhour,C.R.; Cushion,M.T. 2001. Putative transmissive form of Pneumocystis carinii f. sp. carinii The Journal of eukaryotic microbiology, Suppl , 139SIcenhour,C.R.; Rebholz,S.L.; Collins,M.S.; Cushion,M.T. 2001. Early acquisition of Pneumocystis carinii in neonatal rats using targeted PCR and oral swabs The Journal of eukaryotic microbiology, Suppl , 135SIcenhour,C.R.; Rebholz,S.L.; Collins,M.S.; Cushion,M.T. 2001. Widespread occurrence of Pneumocystis carinii in commercial rat colonies detected using targeted PCR and oral swabs Journal of clinical microbiology, 39 10, 3437Keely, S P; Wakefield, A E; Cushion, M T; Smulian, A G; Hall, N; Barrell, B G; Stringer, J R 2001. Detailed structure of Pneumocystis carinii chromosome ends. The Journal of eukaryotic microbiology, Suppl , 118S-120SKeely,S.P.; Wakefield,A.E.; Cushion,M.T.; Smulian,A.G.; Hall,N.; Barrell,B.G.; Stringer,J.R. 2001. Detailed structure of Pneumocystis carinii chromosome ends The Journal of eukaryotic microbiology, Suppl , 118SNahimana, A; Cushion, M T; Blanc, D S; Hauser, P M 2001. Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats. Journal of clinical microbiology, 39 12, 4563-5Nahimana,A.; Cushion,M.T.; Blanc,D.S.; Hauser,P.M. 2001. Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats Journal of clinical microbiology, 39 12, 4563Rebholz, S L; Cushion, M T 2001. Three new karyotype forms of Pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (CHEF) electrophoresis. The Journal of eukaryotic microbiology, Suppl , 109S-110SRebholz,S.L.; Cushion,M.T. 2001. Three new karyotype forms of Pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (CHEF) electrophoresis The Journal of eukaryotic microbiology, Suppl , 109SSmulian, A G; Sesterhenn, T; Tanaka, R; Cushion, M T 2001. The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes. Genetics, 157 3, 991-1002Smulian,A.G.; Sesterhenn,T.; Tanaka,R.; Cushion,M.T. 2001. The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes Genetics, 157 3, 991Stringer, J R; Cushion, M T; Wakefield, A E 2001. New nomenclature for the genus Pneumocystis. The Journal of eukaryotic microbiology, Suppl , 184S-189SStringer,J.R.; Cushion,M.T.; Wakefield,A.E. 2001. New nomenclature for the genus Pneumocystis The Journal of eukaryotic microbiology, Suppl , 184SWalzer, P D; Ashbaugh, A; Collins, M; Cushion, M T 2001. Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo. The Journal of infectious diseases, 184 10, 1355-7Walzer, P D; Ashbaugh, A; Collins, M; Cushion, M T 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii. Antimicrobial agents and chemotherapy, 45 11, 3234-7Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo The Journal of infectious diseases, 184 10, 1355Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii Antimicrobial Agents and Chemotherapy, 45 11, 3234Cushion, M T; Collins, M; Hazra, B; Kaneshiro, E S 2000. Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. Antimicrobial agents and chemotherapy, 44 3, 713-9Cushion,M.T.; Collins,M.; Hazra,B.; Kaneshiro,E.S. 2000. Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii Antimicrobial Agents and Chemotherapy, 44 3, 713Kaneshiro, E S; Collins, M S; Cushion, M T 2000. Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. Antimicrobial agents and chemotherapy, 44 6, 1630-8Kaneshiro,E.S.; Collins,M.S.; Cushion,M.T. 2000. Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii Antimicrobial Agents and Chemotherapy, 44 6, 1630Cushion,M.T. 1999. Summary of the Pneumocystis research presented at the 6th International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, 46 5, 85SCushion,M.T.; Linke,M.J.; Collins,M.; Keely,S.P.; Stringer,J.R. 1999. The minimum number of Pneumocystis carinii f. sp. carinii organisms required to establish infections is very low The Journal of eukaryotic microbiology, 46 5, 111SIcenhour,C.R.; Arnold,J.; Cushion,M.T. 1999. Interactions of two Pneumocystis carinii populations within rat lungs The Journal of eukaryotic microbiology, 46 5, 107SKaneshiro,E.S.; Collins,M.; Cushion,M.T. 1999. Effects of sterol inhibitors on the ATP content of Pneumocystis carinii The Journal of eukaryotic microbiology, 46 5, 142SKeely,S.P.; Cushion,M.T.; Stringer,J.R. 1999. Determination of the maximum frequency of genetic rearrangements associated with Pneumocystis carinii surface antigen variation The Journal of eukaryotic microbiology, 46 5, 128SPalmer, R J; Cushion, M T; Wakefield, A E 1999. Discrimination of rat-derived Pneumocystis carinii f. sp. Carinii and Pneumocystis carinii f. sp. Ratti using the polymerase chain reaction. Molecular and cellular probes, 13 2, 147-55Palmer,R.J.; Cushion,M.T.; Wakefield,A.E. 1999. Discrimination of rat-derived Pneumocystis carinii f. sp. Carinii and Pneumocystis carinii f. sp. Ratti using the polymerase chain reaction Molecular and cellular probes, 13 2, 147Weisbroth, S H; Geistfeld, J; Weisbroth, S P; Williams, B; Feldman, S H; Linke, M J; Orr, S; Cushion, M T 1999. Latent Pneumocystis carinii infection in commercial rat colonies: comparison of inductive immunosuppressants plus histopathology, PCR, and serology as detection methods. Journal of clinical microbiology, 37 5, 1441-6Weisbroth,S.H.; Geistfeld,J.; Weisbroth,S.P.; Williams,B.; Feldman,S.H.; Linke,M.J.; Orr,S.; Cushion,M.T. 1999. Latent Pneumocystis carinii infection in commercial rat colonies: comparison of inductive immunosuppressants plus histopathology, PCR, and serology as detection methods Journal of clinical microbiology, 37 5, 1441Cushion, M T 1998. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii. Seminars in respiratory infections, 13 4, 304-12Cushion, M T 1998. Genetic heterogeneity of rat-derived Pneumocystis. FEMS immunology and medical microbiology, 22 1-2, 51-8Cushion,M.T. 1998. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii Seminars in respiratory infections, 13 4, 304Cushion,M.T. 1998. Genetic heterogeneity of rat-derived Pneumocystis FEMS immunology and medical microbiology, 22 1-2, 51Stringer, J R; Cushion, M T 1998. The genome of Pneumocystis carinii. FEMS immunology and medical microbiology, 22 1-2, 15-26Stringer,J.R.; Cushion,M.T. 1998. The genome of Pneumocystis carinii FEMS immunology and medical microbiology, 22 1-2, 15Arnold,J.; Cushion,M.T. 1997. Constructing a physical map of the Pneumocystis genome The Journal of eukaryotic microbiology, 44 6, 8SBeach, D H; Chen, F; Cushion, M T; Macomber, R S; Krudy, G A; Wyder, M A; Kaneshiro, E S 1997. Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii. Antimicrobial agents and chemotherapy, 41 1, 162-8Beach,D.H.; Chen,F.; Cushion,M.T.; Macomber,R.S.; Krudy,G.A.; Wyder,M.A.; Kaneshiro,E.S. 1997. Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii Antimicrobial Agents and Chemotherapy, 41 1, 162Cushion, M T; Chen, F; Kloepfer, N 1997. A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents. Antimicrobial agents and chemotherapy, 41 2, 379-84Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R 1997. Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, 65 10, 4365; author reply 4Cushion,M.T.; Arnold,J. 1997. Proposal for a Pneumocystis genome project The Journal of eukaryotic microbiology, 44 6, 7SCushion,M.T.; Chen,F.; Kloepfer,N. 1997. A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents Antimicrobial Agents and Chemotherapy, 41 2, 379Cushion,M.T.; Orr,S.; Arnold,J. 1997. Interactions between 2 Pneumocystis populations within the same host The Journal of eukaryotic microbiology, 44 6, 9SCushion,M.T.; Walzer,P.D.; Smulian,A.G.; Linke,M.J.; Ruffolo,J.J.; Kaneshiro,E.S.; Stringer,J.R. 1997. Terminology for the life cycle of Pneumocystis carinii Infection and immunity, 65 10, 4365; author reply 4366Perlada, D E; Smulian, A G; Cushion, M T 1997. Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. Journal of clinical microbiology, 35 9, 2342-7Stringer,J.R.; Wakefield,A.E.; Cushion,M.T.; Dei-Cas,E. 1997. Pneumocystis taxonomy and nomenclature: an update The Journal of eukaryotic microbiology, 44 6, 5SCushion,M.T.; Orr,S. 1996. Kinetics of 2 genetically distinct Pneumocystis carinii populations in rat colonies The Journal of eukaryotic microbiology, 43 5, 46SCushion,M.T.; Walzer,P.D. 1996. Closing comments: a retrospective perspective 4th International Workshop on Pneumocystis The Journal of eukaryotic microbiology, 43 5, 60SKeely,S.P.; Cushion,M.T.; Stringer,J.R. 1996. Stability of four genetic loci in Pneumocystis carinii sp. f. carinii The Journal of eukaryotic microbiology, 43 5, 49SSmulian, A G; Ryan, M; Staben, C; Cushion, M 1996. Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti. Infection and immunity, 64 3, 691-701Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T 1996. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Infection and immunity, 64 1, 290-7Vasquez,J.; Smulian,A.G.; Linke,M.J.; Cushion,M.T. 1996. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats Infection and immunity, 64 1, 290O'Leary, T J; Tsai, M M; Wright, C F; Cushion, M T 1995. Use of semiquantitative PCR to assess onset and treatment of Pneumocystis carinii infection in rat model. Journal of clinical microbiology, 33 3, 718-24O'Leary,T.J.; Tsai,M.M.; Wright,C.F.; Cushion,M.T. 1995. Use of semiquantitative PCR to assess onset and treatment of Pneumocystis carinii infection in rat model Journal of clinical microbiology, 33 3, 718Andrews,R.P.; Theus,S.A.; Cushion,M.T.; Walzer,P.D. 1994. Comparison of the antigenic recognition of the major surface glycoprotein of Pneumocystis carinii isolated from different rat strains The Journal of eukaryotic microbiology, 41 5, 72SChen, F; Cushion, M T 1994. Use of an ATP bioluminescent assay to evaluate viability of Pneumocystis carinii from rats. Journal of clinical microbiology, 32 11, 2791-800Chen,F.; Cushion,M.T. 1994. Use of an ATP bioluminescent assay to evaluate viability of Pneumocystis carinii from rats Journal of clinical microbiology, 32 11, 2791Chen,F.; Cushion,M.T. 1994. Use of fluorescent probes to investigate the metabolic state of Pneumocystis carinii mitochondria The Journal of eukaryotic microbiology, 41 5, 79SCushion, M T; Harmsen, A; Matsumoto, Y; Stringer, J R; Wakefield, A E; Yamada, M 1994. Recent advances in the biology of Pneumocystis carinii. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 32 Suppl 1 , 217-28Cushion,M.T.; Harmsen,A.; Matsumoto,Y.; Stringer,J.R.; Wakefield,A.E.; Yamada,M. 1994. 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Evaluation of procedures used to isolate Pneumocystis carinii from infected rat lungs The Journal of eukaryotic microbiology, 41 5, 95SSettnes,O.P.; Nielsen,P.B.; Bucala,R.; Linke,M.J.; Cushion,M.T. 1994. A survey of birds in Denmark for the presence of Pneumocystis carinii Avian Diseases, 38 1, 1Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), 8 11, 1555-62Smulian,A.G.; Linke,M.J.; Cushion,M.T.; Baughman,R.P.; Frame,P.T.; Dohn,M.N.; White,M.L.; Walzer,P.D. 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity AIDS (London, England), 8 11, 1555Vasquez,J.; Smulian,A.G.; Linke,M.J.; Cushion,M.T. 1994. Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 114SWeinberg,G.A.; Dykstra,C.C.; Durant,P.J.; Cushion,M.T. 1994. Chromosomal localization of 20 genes to five distinct pulsed field gel karyotypic forms of rat Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 117SWeinberg,G.A.; O'Gara,M.J.; Cushion,M.T. 1994. Coinfection of rats with genetically diverse forms of Pneumocystis carinii demonstrated by P. carinii inosine monophosphate dehydrogenase gene polymorphism The Journal of eukaryotic microbiology, 41 5, 119SCushion, M T; Kaselis, M; Stringer, S L; Stringer, J R 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infection and immunity, 61 11, 4801-13Cushion, M T; Zhang, J; Kaselis, M; Giuntoli, D; Stringer, S L; Stringer, J R 1993. Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats. 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Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats Journal of clinical microbiology, 31 2, 244De Stefano, J A; Trinkle, L S; Walzer, P D; Cushion, M T 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates. The Journal of parasitology, 78 2, 271-80De Stefano,J.A.; Trinkle,L.S.; Walzer,P.D.; Cushion,M.T. 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates The Journal of parasitology, 78 2, 271Stringer, J R; Edman, J C; Cushion, M T; Richards, F F; Watanabe, J 1992. The fungal nature of Pneumocystis. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 271-8Stringer,J.R.; Edman,J.C.; Cushion,M.T.; Richards,F.F.; Watanabe,J. 1992. 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Antimicrobial agents and chemotherapy, 67 2, e0147522Cushion, Melanie T; Ashbaugh, Alan; Sayson, Steven G; Mosley, Christopher; Hauser, Philippe M 2022. Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication. Microbiology spectrum, 10 6, e0290622Macioce-Tisdale, Nikeya L; Ashbaugh, Alan; Hendrix, Keeley; Collins, Margaret S; Porollo, Aleksey; Cushion, Melanie T 2022. The Effects of Sex and Strain on Pneumocystis murina Fungal Burdens in Mice. Journal of fungi (Basel, Switzerland), 8 10, Wiederhold, Nathan P; Patterson, Thomas F; Rebholz, Sandra; Boal, Connell W C; Ehrensberger, Monika; Boyle, Ryan; Cushion, Melanie T 2022. The Antifungal and Anti-Pneumocystis Activities of the Novel Compound A3IS (Mycosinate). Antimicrobial agents and chemotherapy, 66 8, e0052122Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. Genomic insights into the host specific adaptation of the Pneumocystis genus. Communications biology, 4 1, 305Cissé, Ousmane H; Ma, Liang; Dekker, John P; Khil, Pavel P; Youn, Jung-Ho; Brenchley, Jason M; Blair, Robert; Pahar, Bapi; Chabé, Magali; Van Rompay, Koen K A; Keesler, Rebekah; Sukura, Antti; Hirsch, Vanessa; Kutty, Geetha; Liu, Yueqin; Peng, Li; Chen, Jie; Song, Jun; Weissenbacher-Lang, Christiane; Xu, Jie; Upham, Nathan S; Stajich, Jason E; Cuomo, Christina A; Cushion, Melanie T; Kovacs, Joseph A 2021. 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Diversity and Complexity of the Large Surface Protein Family in the Compacted Genomes of Multiple Pneumocystis Species. mBio, 11 2, Liu, Guan-Sheng; Ballweg, Richard; Ashbaugh, Alan; Zhang, Yin; Facciolo, Joseph; Cushion, Melanie T; Zhang, Tongli 2019. Correction to: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice. BMC systems biology, 13 1, 40Luraschi, A; Richard, S; Almeida, J M G C F; Pagni, M; Cushion, M T; Hauser, P M 2019. Expression and Immunostaining Analyses Suggest that Pneumocystis Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors. mBio, 10 4, Cushion, Melanie T 2018. Reply to Nevez et al., "The Fascinating Echinocandin-Treated Mouse Model of Pneumocystis murina To Understand Pneumocystis jirovecii". Antimicrobial agents and chemotherapy, 62 8, Cushion, Melanie T; Ashbaugh, Alan; Hendrix, Keeley; Linke, Michael J; Tisdale, Nikeya; Sayson, Steven G; Porollo, Aleksey 2018. 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Correction: Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 11, 2164Maciejewska, D; Zabinski, J; Rezler, M; Kazmierczak, P; Collins, M S; Ficker, L; Cushion, M T 2017. Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity. MedChemComm, 8 10, 2003-2011Baker, Frazier N; Cushion, Melanie T; Porollo, Aleksey 2016. A Quantitative Model to Estimate Drug Resistance in Pathogens. Journal of fungi (Basel, Switzerland), 2 4, Cushion, Melanie T; Collins, Margaret S; Sesterhenn, Thomas; Porollo, Aleksey; Vadukoot, Anish Kizhakkekkara; Merino, Edward J 2016. Functional Characterization of Pneumocystis carinii Inositol Transporter 1. mBio, 7 6, Koselny, Kristy; Green, Julianne; DiDone, Louis; Halterman, Justin P; Fothergill, Annette W; Wiederhold, Nathan P; Patterson, Thomas F; Cushion, Melanie T; Rappelye, Chad; Wellington, Melanie; Krysan, Damian J 2016. The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis. Antimicrobial agents and chemotherapy, 60 12, 7115-7127Calderon, Enrique J; Cushion, Melanie T; Xiao, Lihua; Lorenzo-Morales, Jacob; Matos, Olga; Kaneshiro, Edna S; Weiss, Louis M 2015. The 13th International Workshops on Opportunistic Protists (IWOP13). 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Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. mBio, 5 6, e01834Cushion, Melanie T; Keely, Scott P 2013. Assembly and annotation of Pneumocystis jirovecii from the human lung microbiome. mBio, 4 2, e00224Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T 2013. Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia. Infection and immunity, 81 3, 984-95Lobo, Maria Luísa; Esteves, Francisco; de Sousa, Bruno; Cardoso, Fernando; Cushion, Melanie T; Antunes, Francisco; Matos, Olga 2013. Therapeutic potential of caspofungin combined with trimethoprim-sulfamethoxazole for pneumocystis pneumonia: a pilot study in mice. PloS one, 8 8, e70619Weiss, Louis M; Cushion, Melanie T; Didier, Elizabeth; Xiao, Lihua; Marciano-Cabral, Francine; Sinai, Anthony P; Matos, Olga; Calderon, Enrique J; Kaneshiro, Edna S 2013. The 12th International Workshops on Opportunistic Protists (IWOP-12). The Journal of eukaryotic microbiology, 60 3, 298-308Maciejewska, Dorota; Zabinski, Jerzy; Ka?mierczak, Pawel; Rezler, Mateusz; Krassowska-?wiebocka, Barbara; Collins, Margaret S; Cushion, Melanie T 2012. Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics. European journal of medicinal chemistry, 48 , 164-73Porollo, Aleksey; Meller, Jaroslaw; Joshi, Yogesh; Jaiswal, Vikash; Smulian, A George; Cushion, Melanie T 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current drug targets, 13 12, 1575-85Sinai, Anthony P; Kaneshiro, Edna S; Ward, Honorine; Weiss, Louis M; Cushion, Melanie T 2012. The state of research for AIDS-associated opportunistic infections and the importance of sustaining smaller research communities. Eukaryotic cell, 11 2, 90-7Cushion, Melanie T; Collins, Margaret S 2011. Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures. Antimicrobial agents and chemotherapy, 55 10, 4513-8Cushion, Melanie T 2010. Are members of the fungal genus pneumocystis (a) commensals; (b) opportunists; (c) pathogens; or (d) all of the above? PLoS pathogens, 6 9, Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D 2010. Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection. PloS one, 5 1, e8524Cushion, Melanie T; Stringer, James R 2010. Stealth and opportunism: alternative lifestyles of species in the fungal genus Pneumocystis. Annual review of microbiology, 64 , 431-52Joffrion, Tiffany M; Collins, Margaret S; Sesterhenn, Thomas; Cushion, Melanie T 2010. Functional characterization and localization of Pneumocystis carinii lanosterol synthase. Eukaryotic cell, 9 1, 107-15Joffrion, Tiffany M; Cushion, Melanie T 2010. Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii. FEMS microbiology letters, 311 1, 1-9Sesterhenn, Thomas M; Slaven, Bradley E; Keely, Scott P; Smulian, A George; Lang, B Franz; Cushion, Melanie T 2010. Sequence and structure of the linear mitochondrial genome of Pneumocystis carinii. Molecular genetics and genomics : MGG, 283 1, 63-72Beck, James M; Cushion, Melanie T 2009. Pneumocystis workshop: 10th anniversary summary. Eukaryotic cell, 8 4, 446-60Brubaker, R; Redhead, S A; Stringer, J R; Keely, S P; Cushion, M T 2009. Misinformation about Pneumocystis. Clinical and experimental dermatology, 34 7, e426-7Cushion, Melanie T; Collins, Margaret S; Linke, Michael J 2009. Biofilm formation by Pneumocystis spp. Eukaryotic cell, 8 2, 197-206Cushion, Melanie T; Walzer, Peter D 2009. Preclinical drug discovery for new anti-pneumocystis compounds. Current medicinal chemistry, 16 20, 2514-30Huang, Tien L; Vanden Eynde, Jean Jacques; Mayence, Annie; Collins, Margaret S; Cushion, Melanie T; Rattendi, Donna; Londono, Indira; Mazumder, Lakshman; Bacchi, Cyrus J; Yarlett, Nigel 2009. Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity. Bioorganic & medicinal chemistry letters, 19 20, 5884-6Liu, Yu; Leigh, Jessica W; Brinkmann, Henner; Cushion, Melanie T; Rodriguez-Ezpeleta, Naiara; Philippe, Hervé; Lang, B Franz 2009. Phylogenomic analyses support the monophyly of Taphrinomycotina, including Schizosaccharomyces fission yeasts. Molecular biology and evolution, 26 1, 27-34Vale, Nuno; Prudêncio, Miguel; Marques, Catarina A; Collins, Margaret S; Gut, Jiri; Nogueira, Fátima; Matos, Joana; Rosenthal, Philip J; Cushion, Melanie T; do Rosário, Virgílio E; Mota, Maria M; Moreira, Rui; Gomes, Paula 2009. Imidazoquines as antimalarial and antipneumocystis agents. Journal of medicinal chemistry, 52 23, 7800-7Mayence, Annie; Pietka, Aurélie; Collins, Margaret S; Cushion, Melanie T; Tekwani, Babu L; Huang, Tien L; Vanden Eynde, Jean Jacques 2008. Novel bisbenzimidazoles with antileishmanial effectiveness. Bioorganic & medicinal chemistry letters, 18 8, 2658-61Vale, Nuno; Collins, Margaret S; Gut, Jiri; Ferraz, Ricardo; Rosenthal, Philip J; Cushion, Melanie T; Moreira, Rui; Gomes, Paula 2008. Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorganic & medicinal chemistry letters, 18 2, 485-8Cushion, Melanie T; Smulian, A George; Slaven, Bradley E; Sesterhenn, Tom; Arnold, Jonathan; Staben, Chuck; Porollo, Aleksey; Adamczak, Rafal; Meller, Jarek 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS one, 2 5, e423Cushion,M.T.; Smulian,A.G.; Slaven,B.E.; Sesterhenn,T.; Arnold,J.; Staben,C.; Porollo,A.; Adamczak,R.; Meller,J. 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite PLoS ONE, 2 , e423Keely, Scott P; Linke, Michael J; Cushion, Melanie T; Stringer, James R 2007. Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription. Fungal genetics and biology : FG & B, 44 9, 905-19Keely,S.P.; Linke,M.J.; Cushion,M.T.; Stringer,J.R. 2007. 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Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds. Antimicrobial agents and chemotherapy, 48 11, 4209-16Cushion,M.T. 2004. Pneumocystis: unraveling the cloak of obscurity Trends in microbiology, 12 5, 243Cushion,M.T. 2004. Comparative genomics of Pneumocystis carinii with other protists: implications for life style The Journal of eukaryotic microbiology, 51 1, 30Cushion,M.T.; Walzer,P.D.; Collins,M.S.; Rebholz,S.; Vanden Eynde,J.J.; Mayence,A.; Huang,T.L. 2004. Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds Antimicrobial Agents and Chemotherapy, 48 11, 4209Keely, Scott P; Fischer, Jared M; Cushion, Melanie T; Stringer, James R 2004. Phylogenetic identification of Pneumocystis murina sp. nov., a new species in laboratory mice. 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Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats. Infection and immunity, 71 1, 47-60Keely,S.P.; Cushion,M.T.; Stringer,J.R. 2003. Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats Infection and immunity, 71 1, 47Linke, Michael J; Rebholz, Sandy; Collins, Margaret; Tanaka, Reiko; Cushion, Melanie T 2003. Noninvasive method for monitoring Pneumocystis carinii pneumonia. Emerging infectious diseases, 9 12, 1613-6Linke,M.J.; Rebholz,S.; Collins,M.; Tanaka,R.; Cushion,M.T. 2003. Noninvasive method for monitoring Pneumocystis carinii pneumonia Emerging infectious diseases, 9 12, 1613Sesterhenn, Thomas M; Slaven, Bradley E; Smulian, A George; Cushion, Melanie T 2003. Generation of sequencing libraries for the Pneumocystis Genome project. 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Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats. Journal of clinical microbiology, 39 12, 4563-5Nahimana,A.; Cushion,M.T.; Blanc,D.S.; Hauser,P.M. 2001. Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats Journal of clinical microbiology, 39 12, 4563Rebholz, S L; Cushion, M T 2001. Three new karyotype forms of Pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (CHEF) electrophoresis. The Journal of eukaryotic microbiology, Suppl , 109S-110SRebholz,S.L.; Cushion,M.T. 2001. Three new karyotype forms of Pneumocystis carinii f. sp. carinii identified by contoured clamped homogeneous electrical field (CHEF) electrophoresis The Journal of eukaryotic microbiology, Suppl , 109SSmulian, A G; Sesterhenn, T; Tanaka, R; Cushion, M T 2001. The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes. Genetics, 157 3, 991-1002Smulian,A.G.; Sesterhenn,T.; Tanaka,R.; Cushion,M.T. 2001. The ste3 pheromone receptor gene of Pneumocystis carinii is surrounded by a cluster of signal transduction genes Genetics, 157 3, 991Stringer, J R; Cushion, M T; Wakefield, A E 2001. New nomenclature for the genus Pneumocystis. The Journal of eukaryotic microbiology, Suppl , 184S-189SStringer,J.R.; Cushion,M.T.; Wakefield,A.E. 2001. New nomenclature for the genus Pneumocystis The Journal of eukaryotic microbiology, Suppl , 184SWalzer, P D; Ashbaugh, A; Collins, M; Cushion, M T 2001. Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo. The Journal of infectious diseases, 184 10, 1355-7Walzer, P D; Ashbaugh, A; Collins, M; Cushion, M T 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii. Antimicrobial agents and chemotherapy, 45 11, 3234-7Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. Anti-human immunodeficiency virus drugs are ineffective against Pneumocystis carinii in vitro and in vivo The Journal of infectious diseases, 184 10, 1355Walzer,P.D.; Ashbaugh,A.; Collins,M.; Cushion,M.T. 2001. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii Antimicrobial Agents and Chemotherapy, 45 11, 3234Cushion, M T; Collins, M; Hazra, B; Kaneshiro, E S 2000. Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii. Antimicrobial agents and chemotherapy, 44 3, 713-9Cushion,M.T.; Collins,M.; Hazra,B.; Kaneshiro,E.S. 2000. Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii Antimicrobial Agents and Chemotherapy, 44 3, 713Kaneshiro, E S; Collins, M S; Cushion, M T 2000. Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. Antimicrobial agents and chemotherapy, 44 6, 1630-8Kaneshiro,E.S.; Collins,M.S.; Cushion,M.T. 2000. Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii Antimicrobial Agents and Chemotherapy, 44 6, 1630Cushion,M.T. 1999. Summary of the Pneumocystis research presented at the 6th International Workshop on Opportunistic Protists The Journal of eukaryotic microbiology, 46 5, 85SCushion,M.T.; Linke,M.J.; Collins,M.; Keely,S.P.; Stringer,J.R. 1999. The minimum number of Pneumocystis carinii f. sp. carinii organisms required to establish infections is very low The Journal of eukaryotic microbiology, 46 5, 111SIcenhour,C.R.; Arnold,J.; Cushion,M.T. 1999. Interactions of two Pneumocystis carinii populations within rat lungs The Journal of eukaryotic microbiology, 46 5, 107SKaneshiro,E.S.; Collins,M.; Cushion,M.T. 1999. Effects of sterol inhibitors on the ATP content of Pneumocystis carinii The Journal of eukaryotic microbiology, 46 5, 142SKeely,S.P.; Cushion,M.T.; Stringer,J.R. 1999. Determination of the maximum frequency of genetic rearrangements associated with Pneumocystis carinii surface antigen variation The Journal of eukaryotic microbiology, 46 5, 128SPalmer, R J; Cushion, M T; Wakefield, A E 1999. Discrimination of rat-derived Pneumocystis carinii f. sp. Carinii and Pneumocystis carinii f. sp. Ratti using the polymerase chain reaction. Molecular and cellular probes, 13 2, 147-55Palmer,R.J.; Cushion,M.T.; Wakefield,A.E. 1999. Discrimination of rat-derived Pneumocystis carinii f. sp. Carinii and Pneumocystis carinii f. sp. Ratti using the polymerase chain reaction Molecular and cellular probes, 13 2, 147Weisbroth, S H; Geistfeld, J; Weisbroth, S P; Williams, B; Feldman, S H; Linke, M J; Orr, S; Cushion, M T 1999. Latent Pneumocystis carinii infection in commercial rat colonies: comparison of inductive immunosuppressants plus histopathology, PCR, and serology as detection methods. Journal of clinical microbiology, 37 5, 1441-6Weisbroth,S.H.; Geistfeld,J.; Weisbroth,S.P.; Williams,B.; Feldman,S.H.; Linke,M.J.; Orr,S.; Cushion,M.T. 1999. Latent Pneumocystis carinii infection in commercial rat colonies: comparison of inductive immunosuppressants plus histopathology, PCR, and serology as detection methods Journal of clinical microbiology, 37 5, 1441Cushion, M T 1998. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii. Seminars in respiratory infections, 13 4, 304-12Cushion, M T 1998. Genetic heterogeneity of rat-derived Pneumocystis. FEMS immunology and medical microbiology, 22 1-2, 51-8Cushion,M.T. 1998. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii Seminars in respiratory infections, 13 4, 304Cushion,M.T. 1998. Genetic heterogeneity of rat-derived Pneumocystis FEMS immunology and medical microbiology, 22 1-2, 51Stringer, J R; Cushion, M T 1998. The genome of Pneumocystis carinii. FEMS immunology and medical microbiology, 22 1-2, 15-26Stringer,J.R.; Cushion,M.T. 1998. The genome of Pneumocystis carinii FEMS immunology and medical microbiology, 22 1-2, 15Arnold,J.; Cushion,M.T. 1997. Constructing a physical map of the Pneumocystis genome The Journal of eukaryotic microbiology, 44 6, 8SBeach, D H; Chen, F; Cushion, M T; Macomber, R S; Krudy, G A; Wyder, M A; Kaneshiro, E S 1997. Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii. Antimicrobial agents and chemotherapy, 41 1, 162-8Beach,D.H.; Chen,F.; Cushion,M.T.; Macomber,R.S.; Krudy,G.A.; Wyder,M.A.; Kaneshiro,E.S. 1997. Effects of steroidal allenic phosphonic acid derivatives on the parasitic protists Leishmania donovani, Leishmania mexicana mexicana, and Pneumocystis carinii carinii Antimicrobial Agents and Chemotherapy, 41 1, 162Cushion, M T; Chen, F; Kloepfer, N 1997. A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents. Antimicrobial agents and chemotherapy, 41 2, 379-84Cushion, M T; Walzer, P D; Smulian, A G; Linke, M J; Ruffolo, J J; Kaneshiro, E S; Stringer, J R 1997. Terminology for the life cycle of Pneumocystis carinii. Infection and immunity, 65 10, 4365; author reply 4Cushion,M.T.; Arnold,J. 1997. Proposal for a Pneumocystis genome project The Journal of eukaryotic microbiology, 44 6, 7SCushion,M.T.; Chen,F.; Kloepfer,N. 1997. A cytotoxicity assay for evaluation of candidate anti-Pneumocystis carinii agents Antimicrobial Agents and Chemotherapy, 41 2, 379Cushion,M.T.; Orr,S.; Arnold,J. 1997. Interactions between 2 Pneumocystis populations within the same host The Journal of eukaryotic microbiology, 44 6, 9SCushion,M.T.; Walzer,P.D.; Smulian,A.G.; Linke,M.J.; Ruffolo,J.J.; Kaneshiro,E.S.; Stringer,J.R. 1997. Terminology for the life cycle of Pneumocystis carinii Infection and immunity, 65 10, 4365; author reply 4366Perlada, D E; Smulian, A G; Cushion, M T 1997. Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. Journal of clinical microbiology, 35 9, 2342-7Stringer,J.R.; Wakefield,A.E.; Cushion,M.T.; Dei-Cas,E. 1997. Pneumocystis taxonomy and nomenclature: an update The Journal of eukaryotic microbiology, 44 6, 5SCushion,M.T.; Orr,S. 1996. Kinetics of 2 genetically distinct Pneumocystis carinii populations in rat colonies The Journal of eukaryotic microbiology, 43 5, 46SCushion,M.T.; Walzer,P.D. 1996. Closing comments: a retrospective perspective 4th International Workshop on Pneumocystis The Journal of eukaryotic microbiology, 43 5, 60SKeely,S.P.; Cushion,M.T.; Stringer,J.R. 1996. Stability of four genetic loci in Pneumocystis carinii sp. f. carinii The Journal of eukaryotic microbiology, 43 5, 49SSmulian, A G; Ryan, M; Staben, C; Cushion, M 1996. Signal transduction in Pneumocystis carinii: characterization of the genes (pcg1) encoding the alpha subunit of the G protein (PCG1) of Pneumocystis carinii carinii and Pneumocystis carinii ratti. Infection and immunity, 64 3, 691-701Vasquez, J; Smulian, A G; Linke, M J; Cushion, M T 1996. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats. Infection and immunity, 64 1, 290-7Vasquez,J.; Smulian,A.G.; Linke,M.J.; Cushion,M.T. 1996. Antigenic differences associated with genetically distinct Pneumocystis carinii from rats Infection and immunity, 64 1, 290O'Leary, T J; Tsai, M M; Wright, C F; Cushion, M T 1995. Use of semiquantitative PCR to assess onset and treatment of Pneumocystis carinii infection in rat model. Journal of clinical microbiology, 33 3, 718-24O'Leary,T.J.; Tsai,M.M.; Wright,C.F.; Cushion,M.T. 1995. Use of semiquantitative PCR to assess onset and treatment of Pneumocystis carinii infection in rat model Journal of clinical microbiology, 33 3, 718Andrews,R.P.; Theus,S.A.; Cushion,M.T.; Walzer,P.D. 1994. Comparison of the antigenic recognition of the major surface glycoprotein of Pneumocystis carinii isolated from different rat strains The Journal of eukaryotic microbiology, 41 5, 72SChen, F; Cushion, M T 1994. Use of an ATP bioluminescent assay to evaluate viability of Pneumocystis carinii from rats. Journal of clinical microbiology, 32 11, 2791-800Chen,F.; Cushion,M.T. 1994. Use of an ATP bioluminescent assay to evaluate viability of Pneumocystis carinii from rats Journal of clinical microbiology, 32 11, 2791Chen,F.; Cushion,M.T. 1994. Use of fluorescent probes to investigate the metabolic state of Pneumocystis carinii mitochondria The Journal of eukaryotic microbiology, 41 5, 79SCushion, M T; Harmsen, A; Matsumoto, Y; Stringer, J R; Wakefield, A E; Yamada, M 1994. Recent advances in the biology of Pneumocystis carinii. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 32 Suppl 1 , 217-28Cushion,M.T.; Harmsen,A.; Matsumoto,Y.; Stringer,J.R.; Wakefield,A.E.; Yamada,M. 1994. 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Evaluation of procedures used to isolate Pneumocystis carinii from infected rat lungs The Journal of eukaryotic microbiology, 41 5, 95SSettnes,O.P.; Nielsen,P.B.; Bucala,R.; Linke,M.J.; Cushion,M.T. 1994. A survey of birds in Denmark for the presence of Pneumocystis carinii Avian Diseases, 38 1, 1Smulian, A G; Linke, M J; Cushion, M T; Baughman, R P; Frame, P T; Dohn, M N; White, M L; Walzer, P D 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity. AIDS (London, England), 8 11, 1555-62Smulian,A.G.; Linke,M.J.; Cushion,M.T.; Baughman,R.P.; Frame,P.T.; Dohn,M.N.; White,M.L.; Walzer,P.D. 1994. Analysis of Pneumocystis carinii organism burden, viability and antigens in bronchoalveolar lavage fluid in AIDS patients with pneumocystosis: correlation with disease severity AIDS (London, England), 8 11, 1555Vasquez,J.; Smulian,A.G.; Linke,M.J.; Cushion,M.T. 1994. Antigenic differences among genetically distinct types of rat-derived Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 114SWeinberg,G.A.; Dykstra,C.C.; Durant,P.J.; Cushion,M.T. 1994. Chromosomal localization of 20 genes to five distinct pulsed field gel karyotypic forms of rat Pneumocystis carinii The Journal of eukaryotic microbiology, 41 5, 117SWeinberg,G.A.; O'Gara,M.J.; Cushion,M.T. 1994. Coinfection of rats with genetically diverse forms of Pneumocystis carinii demonstrated by P. carinii inosine monophosphate dehydrogenase gene polymorphism The Journal of eukaryotic microbiology, 41 5, 119SCushion, M T; Kaselis, M; Stringer, S L; Stringer, J R 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies. Infection and immunity, 61 11, 4801-13Cushion, M T; Zhang, J; Kaselis, M; Giuntoli, D; Stringer, S L; Stringer, J R 1993. Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats. Journal of clinical microbiology, 31 5, 1217-23Cushion,M.T.; Kaselis,M.; Stringer,S.L.; Stringer,J.R. 1993. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies Infection and immunity, 61 11, 4801Cushion,M.T.; Zhang,J.; Kaselis,M.; Giuntoli,D.; Stringer,S.L.; Stringer,J.R. 1993. Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats Journal of clinical microbiology, 31 5, 1217Stringer,J.R.; Stringer,S.L.; Zhang,J.; Baughman,R.; Smulian,A.G.; Cushion,M.T. 1993. Molecular genetic distinction of Pneumocystis carinii from rats and humans The Journal of eukaryotic microbiology, 40 6, 733Zhang, J; Cushion, M T; Stringer, J R 1993. Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats. Journal of clinical microbiology, 31 2, 244-8Zhang,J.; Cushion,M.T.; Stringer,J.R. 1993. Molecular characterization of a novel repetitive element from Pneumocystis carinii from rats Journal of clinical microbiology, 31 2, 244De Stefano, J A; Trinkle, L S; Walzer, P D; Cushion, M T 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates. The Journal of parasitology, 78 2, 271-80De Stefano,J.A.; Trinkle,L.S.; Walzer,P.D.; Cushion,M.T. 1992. Flow cytometric analyses of lectin binding to Pneumocystis carinii surface carbohydrates The Journal of parasitology, 78 2, 271Stringer, J R; Edman, J C; Cushion, M T; Richards, F F; Watanabe, J 1992. The fungal nature of Pneumocystis. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 30 Suppl 1 , 271-8Stringer,J.R.; Edman,J.C.; Cushion,M.T.; Richards,F.F.; Watanabe,J. 1992. 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Evidence for an outer surface membrane The Journal of protozoology, 37 5, 428Hong, S T; Steele, P E; Cushion, M T; Walzer, P D; Stringer, S L; Stringer, J R 1990. Pneumocystis carinii karyotypes. Journal of clinical microbiology, 28 8, 1785-95Hong,S.T.; Steele,P.E.; Cushion,M.T.; Walzer,P.D.; Stringer,S.L.; Stringer,J.R. 1990. Pneumocystis carinii karyotypes Journal of clinical microbiology, 28 8, 1785Cushion,M.T. 1989. In vitro studies of Pneumocystis carinii The Journal of protozoology, 36 1, 45Cushion,M.T.; Blase,M.A.; Walzer,P.D. 1989. A method for isolation of RNA from Pneumocystis carinii The Journal of protozoology, 36 1, 12SDe Stefano,J.A.; Cushion,M.T.; Trinkle,L.S.; Walzer,P.D. 1989. Lectins as probes to Pneumocystis carinii surface glycocomplexes The Journal of protozoology, 36 1, 65SKaneshiro,E.S.; Cushion,M.T.; Walzer,P.D.; Jayasimhulu,K. 1989. Analyses of Pneumocystis fatty acids The Journal of protozoology, 36 1, 69SLinke, M J; Cushion, M T; Walzer, P D 1989. Properties of the major antigens of rat and human Pneumocystis carinii. Infection and immunity, 57 5, 1547-55Linke,M.J.; Cushion,M.T.; Walzer,P.D. 1989. Properties of the major antigens of rat and human Pneumocystis carinii Infection and immunity, 57 5, 1547Ruffolo,J.J.; Cushion,M.T.; Walzer,P.D. 1989. Ultrastructural observations on life cycle stages of Pneumocystis carinii The Journal of protozoology, 36 1, 53SStringer, S L; Stringer, J R; Blase, M A; Walzer, P D; Cushion, M T 1989. Pneumocystis carinii: sequence from ribosomal RNA implies a close relationship with fungi. Experimental parasitology, 68 4, 450-61Stringer,S.L.; Hudson,K.; Blase,M.A.; Walzer,P.D.; Cushion,M.T.; Stringer,J.R. 1989. Sequence from ribosomal RNA of Pneumocystis carinii compared to those of four fungi suggests an ascomycetous affinity The Journal of protozoology, 36 1, 14SStringer,S.L.; Stringer,J.R.; Blase,M.A.; Walzer,P.D.; Cushion,M.T. 1989. 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Analysis of the developmental stages of Pneumocystis carinii, in vitro Laboratory investigation; a journal of technical methods and pathology, 58 3, 324Walzer, P D; Kim, C K; Foy, J M; Linke, M J; Cushion, M T 1988. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, 32 1, 96-103Walzer, P D; Kim, C K; Foy, J; Linke, M J; Cushion, M T 1988. Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. Antimicrobial agents and chemotherapy, 32 6, 896-905Walzer,P.D.; Kim,C.K.; Foy,J.; Linke,M.J.; Cushion,M.T. 1988. Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia Antimicrobial Agents and Chemotherapy, 32 6, 896Walzer,P.D.; Kim,C.K.; Foy,J.M.; Linke,M.J.; Cushion,M.T. 1988. 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