Education/CredentialsPostdoctoral Research : University of Cincinnati College of Medicine (Pharmacology and Cell Biophysics)Postdoctoral Fellowship: University of Cincinnati (Immunology)Postdoctoral : Beijing Institute of Radiation MedicineDoctoral Degree: Zhejiang University (Molecular Cell Biology)Master's Degree: Chinese Academy of Sciences (Microbiology)Bachelor's Degree: Nanjing Normal University (Biology) Contact Information Cardiovascular Rsrch Cntr 5923 Office 513-558-2340 Email fangg@ucmail.uc.edu Research InterestsFan laboratory is dedicated to performing cardiovascular research that involves: 1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-triggered cardiovascular dysfunction. Peer Reviewed Publications Wang, Xiaohong; Du, Wa; Li, Yutian; Yang, Hui-Hui; Zhang, Yu; Akbar, Rubab; Morgan, Hannah; Peng, Tianqing; Chen, Jing; Sadayappan, Sakthivel; Hu, Yueh-Chiang; Fan, Yanbo; Huang, Wei; Fan, Guo-Chang 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI insight, 9 5, Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing 2023. Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis. Journal of translational medicine, 21 1, 883Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. Gastroenterology, , Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. bioRxiv : the preprint server for biology, , Liu, Benjamin D; Akbar, Rubab; Oliverio, Anna; Thapa, Kajol; Wang, Xiaohong; Fan, Guo-Chang 2023. Bacterial Extracellular Vesicles in the Regulation of Inflammatory Response and Host-Microbe Interactions. Shock (Augusta, Ga.), , Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Saas, Philippe; Fan, Guo-Chang 2023. Editorial: Hypoxia and inflammation: A two-way street. Frontiers in immunology, 14 , 1171116Wu, Zhichao; Huang, Wei; He, Xingyu; Dutta, Suchandrima; Paul, Christian; Fan, Guo-Chang; Kanisicak, Onur; Xu, Meifeng; Liang, Jialiang; Wang, Yigang 2023. Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury. bioRxiv : the preprint server for biology, , Yang, Hui-Hui; Wang, Xiaohong; Li, Siru; Liu, Yueying; Akbar, Rubab; Fan, Guo-Chang 2023. Lipocalin family proteins and their diverse roles in cardiovascular disease. Pharmacology & therapeutics, 244 , 108385Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway. Cardiovascular research, , Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Li, Lan; Liao, Guangneng; Lu, Yanrong; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing 2022. MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes. Cardiovascular diabetology, 21 1, 165Feng, Yuliang; Cai, Liuyang; Hong, Wanzi; Zhang, Chunxiang; Tan, Ning; Wang, Mingyang; Wang, Cheng; Liu, Feng; Wang, Xiaohong; Ma, Jianyong; Gao, Chen; Kumar, Mohit; Mo, Yuanxi; Geng, Qingshan; Luo, Changjun; Lin, Yan; Chen, Haiyang; Wang, Shuang-Yin; Watson, Michael J; Jegga, Anil G; Pedersen, Roger A; Fu, Ji-Dong; Wang, Zhao V; Fan, Guo-Chang; Sadayappan, Sakthivel; Wang, Yigang; Pauklin, Siim; Huang, Feng; Huang, Wei; Jiang, Lei 2022. Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation, 145 22, 1663-1683Ji, Xiao-Yun; Zheng, Dong; Ni, Rui; Wang, Jin-Xi; Shao, Jian-Qiang; Vue, Zer; Hinton, Antentor; Song, Long-Sheng; Fan, Guo-Chang; Chakrabarti, Subrata; Su, Zhao-Liang; Peng, Tian-Qing 2022. Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. Acta pharmacologica Sinica, 43 11, 2873-2884Jiang, Lin; Liang, Jialiang; Huang, Wei; Ma, Jianyong; Park, Ki Ho; Wu, Zhichao; Chen, Peng; Zhu, Hua; Ma, Jian-Jie; Cai, Wenfeng; Paul, Christian; Niu, Liang; Fan, Guo-Chang; Wang, Hong-Sheng; Kanisicak, Onur; Xu, Meifeng; Wang, Yigang 2022. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Molecular therapy : the journal of the American Society of Gene Therapy, 30 1, 54-74Li, Huili; Cao, Ting; Ding, Weimin; Liang, Liwen; Fan, Guo-Chang; Qu, Lina; Peng, Tianqing 2022. Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice. Journal of cardiovascular translational research, 15 4, 805-815Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang 2022. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in immunology, 13 , 930397Zhang, Mengxiao; Zhong, Huiting; Cao, Ting; Huang, Yifan; Ji, Xiaoyun; Fan, Guo-Chang; Peng, Tianqing 2022. Gamma-Aminobutyrate Transaminase Protects against Lipid Overload-Triggered Cardiac Injury in Mice. International journal of molecular sciences, 23 4, Cui, Shu-Nan; Tan, Hong-Yu; Fan, Guo-Chang 2021. Immunopathological Roles of Neutrophils in Virus Infection and COVID-19. Shock (Augusta, Ga.), , Mu, Xingjiang; Fan, Hongkuan; Wang, Peng; Li, Yutian; Domenico, Karen; Li, Qianqian; Wang, Xiaohong; Essandoh, Kobina; Chen, Jing; Peng, Tianqing; Fan, Guo-Chang 2021. Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal. Molecular therapy : the journal of the American Society of Gene Therapy, 29 3, 1294-1311Wang, Peng; Mu, Xingjiang; Zhao, Hongyan; Li, Yutian; Wang, Lu; Wolfe, Vivian; Cui, Shu-Nan; Wang, Xiaohong; Peng, Tianqing; Zingarelli, Basilia; Wang, Chunting; Fan, Guo-Chang 2021. Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXR?-Mediated Macrophage Phagocytosis. Frontiers in immunology, 12 , 647070Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang 2020. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox biology, 32 , 101453Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Li, Yutian; Li, Qianqian; Mu, Xingjiang; Peng, Tianqing; Fan, Guo-Chang 2020. Tsg101 Is Involved in the Sorting and Re-Distribution of Glucose Transporter-4 to the Sarcolemma Membrane of Cardiac Myocytes. Cells, 9 9, Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang 2020. Sectm1a Deficiency Aggravates Inflammation-Triggered Cardiac Dysfunction through Disruption of LXR? Signaling in Macrophages. Cardiovascular research, , Li, Yutian; Li, Qianqian; Fan, Guo-Chang 2020. Macrophage Efferocytosis in Cardiac Pathophysiology and Repair. Shock (Augusta, Ga.), , Liang, Liwen; Li, Huili; Cao, Ting; Qu, Lina; Zhang, Lulu; Fan, Guo-Chang; Greer, Peter A; Li, Jianmin; Jones, Douglas L; Peng, Tianqing 2020. Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways. The Journal of biological chemistry, 295 49, 16840-16851Liang, Liwen; Li, Huili; Cao, Ting; Qu, Lina; Zhang, Lulu; Fan, Guo-Chang; Greer, Peter A; Li, Jianmin; Jones, Douglas L; Peng, Tianqing 2020. Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways. The Journal of biological chemistry, 295 49, 16840-16851Mu, Xingjiang; Li, Yutian; Fan, Guo-Chang 2020. Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation. Shock (Augusta, Ga.), , Mu, Xingjiang; Wang, Peng; Wang, Xiaohong; Li, Yutian; Zhao, Hongyan; Li, Qianqian; Essandoh, Kobina; Deng, Shan; Peng, Tianqing; Fan, Guo-Chang 2020. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR. Journal of immunology (Baltimore, Md. : 1950), 205 6, 1633-1643Wang, Lu; Li, Yutian; Wang, Xiaohong; Wang, Peng; Essandoh, Kobina; Cui, Shunan; Huang, Wei; Mu, Xingjiang; Liu, Zhenling; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang 2020. GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. Cells, 9 1, Zheng, Dong; Cao, Ting; Zhang, Lu-Lu; Fan, Guo-Chang; Qiu, Jun; Peng, Tian-Qing 2020. Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. Acta pharmacologica Sinica, , Cao, Ting; Fan, Shuai; Zheng, Dong; Wang, Grace; Yu, Yong; Chen, Ruizhen; Song, Long-Sheng; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing 2019. Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion. Basic research in cardiology, 114 3, 17Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Jiang, Min; Mu, Xingjiang; Peng, Jiangtong; Li, Yutian; Peng, Tianqing; Wagner, Kay-Uwe; Rubinstein, Jack; Fan, Guo-Chang 2019. Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 6, 7451-7466Essandoh, Kobina; Wang, Xiaohong; Huang, Wei; Deng, Shan; Gardner, George; Mu, Xingjiang; Li, Yutian; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2019. Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy. The Journal of biological chemistry, 294 48, 18057-18068Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G 2019. Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure. JACC. Basic to translational science, 4 2, 188-199Li, Yutian; Deng, Shan; Peng, Jiangtong; Wang, Xiaohong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Meng, Zhuo-Xian; Fan, Guo-Chang 2019. MicroRNA-223 is essential for maintaining functional ?-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways. The Journal of biological chemistry, 294 27, 10438-10448Liang, Liwen; Yuan, Wenyi; Qu, Lina; Li, Huili; Zhang, Lulu; Fan, Guo-Chang; Peng, Tianqing 2019. Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression. Journal of translational medicine, 17 1, 279Ren, Xiaoping; Roessler, Anne E; Lynch, Thomas L; Haar, Lauren; Mallick, Faryal; Lui, Yong; Tranter, Michael; Ren, Michelle Huan; Xie, Wen Rui; Fan, Guo-Chang; Zhang, Jun-Ming; Kranias, Evangelia G; Anjak, Ahmad; Koch, Sheryl; Jiang, Min; Miao, Qing; Wang, Yang; Cohen, Albert; Rubinstein, Jack; Weintraub, Neal L; Jones, W Keith 2019. Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time. American journal of physiology. Heart and circulatory physiology, 316 3, H543-H553Teng, Xiaomei; Ji, Chen; Zhong, Huiting; Zheng, Dong; Ni, Rui; Hill, David J; Xiong, Sidong; Fan, Guo-Chang; Greer, Peter A; Shen, Zhenya; Peng, Tianqing 2019. Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis. Diabetologia, 62 5, 860-872Zheng, Dong; Su, Zhaoliang; Zhang, Yi; Ni, Rui; Fan, Guo-Chang; Robbins, Jeffrey; Song, Long-Sheng; Li, Jianmin; Peng, Tianqing 2019. Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity. Archives of toxicology, 93 4, 1051-1065Zheng, Dong; Zhang, Yi; Zheng, Ming; Cao, Ting; Wang, Grace; Zhang, Lulu; Ni, Rui; Brockman, Joseph; Zhong, Huiting; Fan, Guo-Chang; Peng, Tianqing 2019. Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity. Clinical science (London, England : 1979), 133 13, 1505-1521Chen, Yanfang; Tang, Yaoliang; Fan, Guo-Chang; Duan, Dayue Darrel 2018. Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases. Acta pharmacologica Sinica, 39 4, 499-500Hong, Guangliang; Zheng, Dong; Zhang, Lulu; Ni, Rui; Wang, Grace; Fan, Guo-Chang; Lu, Zhongqiu; Peng, Tianqing 2018. Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis. Free radical biology & medicine, 123 , 125-137Liu, Guan-Sheng; Zhu, Hongyan; Cai, Wen-Feng; Wang, Xiaohong; Jiang, Min; Essandoh, Kobina; Vafiadaki, Elizabeth; Haghighi, Kobra; Lam, Chi Keung; Gardner, George; Adly, George; Nicolaou, Persoulla; Sanoudou, Despina; Liang, Qiangrong; Rubinstein, Jack; Fan, Guo-Chang; Kranias, Evangelia G 2018. Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant. Autophagy, 14 1, 80-97Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang 2018. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination. Cell reports, 23 12, 3607-3620Yu, You-Jiang; Wang, Xiao-Hong; Fan, Guo-Chang 2018. Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases. Acta pharmacologica Sinica, 39 4, 514-533Li, S; Zhang, L; Ni, R; Cao, T; Zheng, D; Xiong, S; Greer, P A; Fan, G C; Peng, T 2017. Corrigendum to "Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress" [Biochim. Biophy.Acta 1862 (11): 2023-2033]. Biochimica et biophysica acta. Molecular basis of disease, 1863 9, 2409Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang 2017. Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation. Shock (Augusta, Ga.), , Salem, Esam S B; Fan, Guo-Chang 2017. Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy. Advances in experimental medicine and biology, 998 , 113-138Essandoh, Kobina; Li, Yutian; Huo, Jiuzhou; Fan, Guo-Chang 2016. MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response. Shock (Augusta, Ga.), 46 2, 122-31Hu, Jing; Al-Waili, Daniah; Hassan, Aishlin; Fan, Guo-Chang; Xin, Mei; Hao, Jiukuan 2016. Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex. Neuroscience, 329 , 30-42Li, Shengcun; Zhang, Lulu; Ni, Rui; Cao, Ting; Zheng, Dong; Xiong, Sidong; Greer, Peter A; Fan, Guo-Chang; Peng, Tianqing 2016. Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. Biochimica et biophysica acta, 1862 11, 2023-2033Liu, Zhi-Feng; Zheng, Dong; Fan, Guo-Chang; Peng, Tianqing; Su, Lei 2016. Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling. Apoptosis : an international journal on programmed cell death, 21 8, 896-904Ni, Rui; Cao, Ting; Xiong, Sidong; Ma, Jian; Fan, Guo-Chang; Lacefield, James C; Lu, Yanrong; Le Tissier, Sydney; Peng, Tianqing 2016. Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy. Free radical biology & medicine, 90 , 12-23Ni, Rui; Zheng, Dong; Xiong, Sidong; Hill, David J; Sun, Tao; Gardiner, Richard B; Fan, Guo-Chang; Lu, Yanrong; Abel, E Dale; Greer, Peter A; Peng, Tianqing 2016. Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes, 65 1, 255-68Qin, Dongze; Wang, Xiaohong; Li, Yutian; Yang, Liwang; Wang, Ruitao; Peng, Jiangtong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Han, Qinghua; Yu, Kai-Jiang; Fan, Guo-Chang 2016. MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts. The Journal of biological chemistry, 291 38, 20247-59Wang, Xiaohong; Gu, Haitao; Huang, Wei; Peng, Jiangtong; Li, Yutian; Yang, Liwang; Qin, Dongze; Essandoh, Kobina; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang 2016. Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Diabetes, 65 10, 3111-28Yang, Liwang; Li, Yutian; Wang, Xiaohong; Mu, Xingjiang; Qin, Dongze; Huang, Wei; Alshahrani, Saeed; Nieman, Michelle; Peng, Jiangtong; Essandoh, Kobina; Peng, Tianqing; Wang, Yigang; Lorenz, John; Soleimani, Manoocher; Zhao, Zhi-Qing; Fan, Guo-Chang 2016. Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy. The Journal of biological chemistry, 291 30, 15700-13Zheng, Dong; Yu, Yong; Li, Minghui; Wang, Grace; Chen, Ruizhen; Fan, Guo-Chang; Martin, Claudio; Xiong, Sidong; Peng, Tianqing 2016. Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis. The Journal of infectious diseases, 213 10, 1661-70Ailawadi, Shaina; Wang, Xiaohong; Gu, Haitao; Fan, Guo-Chang 2015. Pathologic function and therapeutic potential of exosomes in cardiovascular disease. Biochimica et biophysica acta, 1852 1, 1-11Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G 2015. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. European journal of heart failure, 17 8, 782-93Essandoh, Kobina; Yang, Liwang; Wang, Xiaohong; Huang, Wei; Qin, Dongze; Hao, Jiukuan; Wang, Yigang; Zingarelli, Basilia; Peng, Tianqing; Fan, Guo-Chang 2015. Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction. Biochimica et biophysica acta, 1852 11, 2362-71Ni, Rui; Zheng, Dong; Wang, Qiang; Yu, Yong; Chen, Ruizhen; Sun, Tao; Wang, Wang; Fan, Guo-Chang; Greer, Peter A; Gardiner, Richard B; Peng, Tianqing 2015. Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation. Circulation. Heart failure, 8 5, 988-96Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang 2015. Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. Scientific reports, 5 , 13721Zheng, Dong; Ma, Jian; Yu, Yong; Li, Minghui; Ni, Rui; Wang, Grace; Chen, Ruizhen; Li, Jianmin; Fan, Guo-Chang; Lacefield, James C; Peng, Tianqing 2015. Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia, 58 8, 1949-58Zheng, Dong; Wang, Grace; Li, Shuai; Fan, Guo-Chang; Peng, Tianqing 2015. Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation. Biochimica et biophysica acta, 1852 5, 882-92Essandoh, Kobina; Fan, Guo-Chang 2014. Role of extracellular and intracellular microRNAs in sepsis. Biochimica et biophysica acta, 1842 11, 2155-2162Essandoh, Kobina; Fan, Guo-Chang 2014. Role of extracellular and intracellular microRNAs in sepsis. Biochimica et biophysica acta, 1842 11, 2155-2162Fan, Guo-Chang 2014. Hypoxic exosomes promote angiogenesis. Blood, 124 25, 3669-70Jiang, Ding-Sheng; Liu, Yu; Zhou, Heng; Zhang, Yan; Zhang, Xiao-Dong; Zhang, Xiao-Fei; Chen, Ke; Gao, Lu; Peng, Juan; Gong, Hui; Chen, Yingjie; Yang, Qinglin; Liu, Peter P; Fan, Guo-Chang; Zou, Yunzeng; Li, Hongliang 2014. Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy. Hypertension, , Jiang, Ding-Sheng; Wei, Xiang; Zhang, Xiao-Fei; Liu, Yu; Zhang, Yan; Chen, Ke; Gao, Lu; Zhou, Heng; Zhu, Xue-Hai; Liu, Peter P; Bond Lau, Wayne; Ma, Xinliang; Zou, Yunzeng; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang 2014. IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling. Nature communications, 5 , 3303Li, Shang-Ze; Zhang, Hui-Hui; Liang, Jun-Bo; Song, Yang; Jin, Bing-Xue; Xing, Na-Na; Fan, Guo-Chang; Du, Run-Lei; Zhang, Xiao-Dong 2014. Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK?. Biochimica et biophysica acta, 1843 7, 1365-72Liu, Yi; Jiang, Xiao-Li; Liu, Yu; Jiang, Ding-Sheng; Zhang, Yan; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang 2014. Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice. Cardiovascular research, 101 1, 87-96Wang, Xiaohong; Huang, Wei; Liu, Guansheng; Cai, Wenfeng; Millard, Ronald W; Wang, Yigang; Chang, Jiang; Peng, Tianqing; Fan, Guo-Chang 2014. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. Journal of molecular and cellular cardiology, , Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang 2014. Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochimica et biophysica acta, 1842 5, 701-711Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang 2014. MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF. PloS one, 9 9, e104666Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang 2014. MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PloS one, 9 9, e104666Yue, X; Yang, X; Lin, X; Yang, T; Yi, X; Dai, Y; Guo, J; Li, T; Shi, J; Wei, L; Fan, G-C; Chen, C; Chang, J 2014. Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell death & disease, 5 , e1284Zhang, Yan; Liu, Yu; Zhu, Xue-Hai; Zhang, Xiao-Dong; Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Xiao-Fei; Chen, Ke; Wei, Xiang; Gao, Lu; Zhu, Li-Hua; Yang, Qinglin; Fan, Guo-Chang; Lau, Wayne B; Ma, Xinliang; Li, Hongliang 2014. 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Hypertension, , Jiang, Ding-Sheng; Zhang, Xiao-Fei; Gao, Lu; Zong, Jing; Zhou, Heng; Liu, Yu; Zhang, Yan; Bian, Zhou-Yan; Zhu, Li-Hua; Fan, Guo-Chang; Zhang, Xiao-Dong; Li, Hongliang 2013. Signal Regulatory Protein-? Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling. Hypertension, , Li, Qi; Guo, Junli; Lin, Xi; Yang, Xiangsheng; Ma, Yanlin; Fan, Guo-Chang; Chang, Jiang 2013. An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression. PloS one, 8 9, e75470Lu, Yan-Yun; Li, Zuo-Zhi; Jiang, Ding-Sheng; Wang, Lang; Zhang, Yan; Chen, Ke; Zhang, Xiao-Fei; Liu, Yi; Fan, Guo-Chang; Chen, Yingjie; Yang, Qinglin; Zhou, Yan; Zhang, Xiao-Dong; Liu, De-Pei; Li, Hongliang 2013. TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death. Nature communications, 4 , 2852Ribeiro, Mara Fernandes; Zhu, Hongyan; Millard, Ronald W; Fan, Guo-Chang 2013. Exosomes Function in Pro- and Anti-Angiogenesis. Current angiogenesis, 2 1, 54-59Zhu, Hongyan; Fan, Guo-Chang 2013. Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction. Journal of biomarkers in drug development, 1 1, Zhu, Hongyan; Fan, Guo-Chang 2013. Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction. Journal of biomarkers in drug development, 1 1, Fan, Guo-Chang 2012. Role of heat shock proteins in stem cell behavior. Progress in molecular biology and translational science, 111 , 305-22Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G 2012. The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Journal of molecular and cellular cardiology, 52 3, 773-82Huang, Wei; Wang, Tao; Zhang, Dongsheng; Zhao, Tiemin; Dai, Bo; Ashraf, Atif; Wang, Xiaohong; Xu, Meifeng; Millard, Ronald W; Fan, Guo-Chang; Ashraf, Muhammad; Yu, Xi-Yong; Wang, Yigang 2012. Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9. Stem cells and development, 21 5, 778-89Ma, Jian; Wei, Meng; Wang, Qiang; Li, Jianmin; Wang, Hao; Liu, Weihua; Lacefield, James C; Greer, Peter A; Karmazyn, Morris; Fan, Guo-Chang; Peng, Tianqing 2012. Deficiency of Capn4 gene inhibits nuclear factor-?B (NF-?B) protein signaling/inflammation and reduces remodeling after myocardial infarction. The Journal of biological chemistry, 287 33, 27480-9Ma, Yonggang; Zhang, Xiaowei; Bao, Huayan; Mi, Su; Cai, Wenfeng; Yan, Huimin; Wang, Qingqing; Wang, Ziyan; Yan, Jun; Fan, Guo-Chang; Fan, Guochang; Lindsey, Merry L; Hu, Zhuowei 2012. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PloS one, 7 7, e40763Wang, Xiaohong; Zhu, Hongyan; Zhang, Xiaowei; Liu, Yong; Chen, Jing; Medvedovic, Mario; Li, Hongliang; Weiss, Mitchell J; Ren, Xiaoping; Fan, Guo-Chang 2012. Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1. Cardiovascular research, 94 2, 379-90Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Kranias, Evangelia G; Tang, Yaoliang; Peng, Tianqing; Chang, Jiang; Fan, Guo-Chang 2012. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PloS one, 7 3, e32765Zhu, Hongyan; Fan, Guo-Chang 2012. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovascular research, 94 2, 284-92Zuo, Shi; Jones, W Keith; Li, Hongxia; He, Zhisong; Pasha, Zeeshan; Yang, Yueting; Wang, Yigang; Fan, Guo-Chang; Ashraf, Muhammad; Xu, Meifeng 2012. Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury. Stem cells and development, 21 4, 598-608Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G 2011. Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling. Circulation research, 108 12, 1429-38Zhu, Hongyan; Fan, Guo-Chang 2011. Extracellular/circulating microRNAs and their potential role in cardiovascular disease. American journal of cardiovascular disease, 1 2, 138-149Chen, Guoli; Zhou, Xiaoyang; Florea, Stela; Qian, Jiang; Cai, Wenfeng; Zhang, Zhiguo; Fan, Guo-Chang; Lorenz, John; Hajjar, Roger J; Kranias, Evangelia G 2010. Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis. Basic research in cardiology, 105 5, 573-81Fan, Guo-Chang; Kranias, Evangelia G 2010. Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure. Journal of molecular and cellular cardiology, , Huang, Wei; Zhang, Dongsheng; Millard, Ronald W; Wang, Tao; Zhao, Tiemin; Fan, Guo-Chang; Ashraf, Atif; Xu, Meifeng; Ashraf, Muhammad; Wang, Yigang 2010. Gene manipulated peritoneal cell patch repairs infarcted myocardium. Journal of molecular and cellular cardiology, 48 4, 702-12Wang, Xiaohong; Zhang, Xiaowei; Ren, Xiao-Ping; Chen, Jing; Liu, Hongzhu; Yang, Junqi; Medvedovic, Mario; Hu, Zhuowei; Fan, Guo-Chang 2010. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Circulation, 122 13, 1308-18Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Zhu, Cheng; Wang, Yigang; Pu, William T; Jegga, Anil G; Fan, Guo-Chang 2010. Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. Journal of molecular and cellular cardiology, 49 5, 841-50Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation, 120 11 Suppl, S1-9Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping 2009. Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation, 120 11 Suppl, S1-9Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G 2009. Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death. Circulation research, 105 12, 1223-31Ren, Xiao-Ping; Wu, Jinghai; Wang, Xiaohong; Sartor, Maureen A; Qian, Jiang; Jones, Keith; Nicolaou, Persoulla; Pritchard, Tracy J; Fan, Guo-Chang 2009. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation, 119 17, 2357-66Wang, Xiaohong; Zhao, Tiemin; Huang, Wei; Wang, Tao; Qian, Jiang; Xu, Meifeng; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2009. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem cells (Dayton, Ohio), 27 12, 3021-31Wang, Xiaohong; Zingarelli, Basilia; O'Connor, Michael; Zhang, Pengyuan; Adeyemo, Adeola; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang 2009. Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation. Journal of molecular and cellular cardiology, 47 3, 382-90Zhao, Wen; Fan, Guo-Chang; Zhang, Zhi-Guo; Bandyopadhyay, Arun; Zhou, Xiaoyang; Kranias, Evangelia G 2009. Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis. Basic research in cardiology, 104 4, 377-89Chen, Guoli; Zhou, Xiaoyang; Nicolaou, Persoulla; Rodriguez, Patricia; Song, Guojie; Mitton, Bryan; Pathak, Anand; Zachariah, Amit; Fan, Guo-Chang; Dorn, Gerald W; Kranias, Evangelia G 2008. A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 22 6, 1790-6Fan, Guo-Chang; Yuan, Qunying; Kranias, Evangelia G 2008. Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function. Trends in cardiovascular medicine, 18 1, 1-5Fan, Guo-Chang; Zhou, Xiaoyang; Wang, Xiaohong; Song, Guojie; Qian, Jiang; Nicolaou, Persoulla; Chen, Guoli; Ren, Xiaoping; Kranias, Evangelia G 2008. Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity. Circulation research, 103 11, 1270-9Haghighi, Kobra; Chen, Guoli; Sato, Yoji; Fan, Guo-Chang; He, Suiwen; Kolokathis, Fotis; Pater, Luke; Paraskevaidis, Ioannis; Jones, W Keith; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2008. A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids. Human mutation, 29 5, 640-7Nicolaou, Persoulla; Knöll, Ralph; Haghighi, Kobra; Fan, Guo-Chang; Dorn, Gerald W; Hasenfub, Gerd; Kranias, Evangelia G 2008. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of biological chemistry, 283 48, 33465-71Zhang, Dongsheng; Fan, Guo-Chang; Zhou, Xiaoyang; Zhao, Tiemin; Pasha, Zeeshan; Xu, Meifeng; Zhu, Yi; Ashraf, Muhammad; Wang, Yigang 2008. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. Journal of molecular and cellular cardiology, 44 2, 281-92Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Fan, Guo-Chang; Mitton, Bryan A; Gregory, Kimberly N; Del Monte, Federica; Kontrogianni-Konstantopoulos, Aikaterini; Sanoudou, Despina; Kranias, Evangelia G 2007. Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase. American journal of physiology. Heart and circulatory physiology, 293 3, H1581-9Fan, Guo-Chang; Yuan, Qunying; Zhao, Wen; Chu, Guoxiang; Kranias, Evangelia G 2007. Junctin is a prominent regulator of contractility in cardiomyocytes. Biochemical and biophysical research communications, 352 3, 617-22Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G 2007. Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation, 115 3, 300-9Zhou, Xiaoyang; Fan, Guo-Chang; Ren, Xiaoping; Waggoner, Jason R; Gregory, Kimberly N; Chen, Guoli; Jones, W Keith; Kranias, Evangelia G 2007. Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury. Cardiovascular research, 75 3, 487-97Fan, Guo-Chang; Yuan, Qunying; Song, Guojie; Wang, Yigang; Chen, Guoli; Qian, Jiang; Zhou, Xiaoyang; Lee, Yong J; Ashraf, Muhammad; Kranias, Evangelia G 2006. Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circulation research, 99 11, 1233-42Haghighi, Kobra; Kolokathis, Fotis; Gramolini, Anthony O; Waggoner, Jason R; Pater, Luke; Lynch, Roy A; Fan, Guo-Chang; Tsiapras, Dimitris; Parekh, Rohan R; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios Th; Kranias, Evangelia G 2006. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America, 103 5, 1388-93Fan, Guo-Chang; Chu, Guoxiang; Kranias, Evangelia G 2005. Hsp20 and its cardioprotection. Trends in cardiovascular medicine, 15 4, 138-41Fan, Guo-Chang; Ren, Xiaoping; Qian, Jiang; Yuan, Qunying; Nicolaou, Persoulla; Wang, Yang; Jones, W Keith; Chu, Guoxiang; Kranias, Evangelia G 2005. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation, 111 14, 1792-9Chu, Guoxiang; Egnaczyk, Gregory F; Zhao, Wen; Jo, Su-Hyun; Fan, Guo-Chang; Maggio, John E; Xiao, Rui-Ping; Kranias, Evangelia G 2004. Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20. Circulation research, 94 2, 184-93Fan, Guo-Chang; Chu, Guoxiang; Mitton, Bryan; Song, Qiujing; Yuan, Qunying; Kranias, Evangelia G 2004. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circulation research, 94 11, 1474-82Fan, Guo-Chang; Gregory, Kimberly N; Zhao, Wen; Park, Woo Jin; Kranias, Evangelia G 2004. Regulation of myocardial function by histidine-rich, calcium-binding protein. American journal of physiology. Heart and circulatory physiology, 287 4, H1705-11Haghighi, Kobra; Kolokathis, Fotis; Pater, Luke; Lynch, Roy A; Asahi, Michio; Gramolini, Anthony O; Fan, Guo-Chang; Tsiapras, Dimitris; Hahn, Harvey S; Adamopoulos, Stamatis; Liggett, Stephen B; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios T; Kranias, Evangelia G 2003. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of clinical investigation, 111 6, 869-76Fan, Guo-Chang; Singh, Ram Raj 2002. Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. The Journal of experimental medicine, 196 6, 731-41
Research InterestsFan laboratory is dedicated to performing cardiovascular research that involves: 1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-triggered cardiovascular dysfunction.
Peer Reviewed Publications Wang, Xiaohong; Du, Wa; Li, Yutian; Yang, Hui-Hui; Zhang, Yu; Akbar, Rubab; Morgan, Hannah; Peng, Tianqing; Chen, Jing; Sadayappan, Sakthivel; Hu, Yueh-Chiang; Fan, Yanbo; Huang, Wei; Fan, Guo-Chang 2024. Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury. JCI insight, 9 5, Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing 2023. Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis. Journal of translational medicine, 21 1, 883Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma. Gastroenterology, , Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim 2023. BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma. bioRxiv : the preprint server for biology, , Liu, Benjamin D; Akbar, Rubab; Oliverio, Anna; Thapa, Kajol; Wang, Xiaohong; Fan, Guo-Chang 2023. Bacterial Extracellular Vesicles in the Regulation of Inflammatory Response and Host-Microbe Interactions. Shock (Augusta, Ga.), , Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo 2023. Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice. iScience, 26 1, 105769Saas, Philippe; Fan, Guo-Chang 2023. Editorial: Hypoxia and inflammation: A two-way street. Frontiers in immunology, 14 , 1171116Wu, Zhichao; Huang, Wei; He, Xingyu; Dutta, Suchandrima; Paul, Christian; Fan, Guo-Chang; Kanisicak, Onur; Xu, Meifeng; Liang, Jialiang; Wang, Yigang 2023. Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury. bioRxiv : the preprint server for biology, , Yang, Hui-Hui; Wang, Xiaohong; Li, Siru; Liu, Yueying; Akbar, Rubab; Fan, Guo-Chang 2023. Lipocalin family proteins and their diverse roles in cardiovascular disease. Pharmacology & therapeutics, 244 , 108385Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang 2023. Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway. Cardiovascular research, , Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Li, Lan; Liao, Guangneng; Lu, Yanrong; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing 2022. MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes. Cardiovascular diabetology, 21 1, 165Feng, Yuliang; Cai, Liuyang; Hong, Wanzi; Zhang, Chunxiang; Tan, Ning; Wang, Mingyang; Wang, Cheng; Liu, Feng; Wang, Xiaohong; Ma, Jianyong; Gao, Chen; Kumar, Mohit; Mo, Yuanxi; Geng, Qingshan; Luo, Changjun; Lin, Yan; Chen, Haiyang; Wang, Shuang-Yin; Watson, Michael J; Jegga, Anil G; Pedersen, Roger A; Fu, Ji-Dong; Wang, Zhao V; Fan, Guo-Chang; Sadayappan, Sakthivel; Wang, Yigang; Pauklin, Siim; Huang, Feng; Huang, Wei; Jiang, Lei 2022. Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation, 145 22, 1663-1683Ji, Xiao-Yun; Zheng, Dong; Ni, Rui; Wang, Jin-Xi; Shao, Jian-Qiang; Vue, Zer; Hinton, Antentor; Song, Long-Sheng; Fan, Guo-Chang; Chakrabarti, Subrata; Su, Zhao-Liang; Peng, Tian-Qing 2022. Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. Acta pharmacologica Sinica, 43 11, 2873-2884Jiang, Lin; Liang, Jialiang; Huang, Wei; Ma, Jianyong; Park, Ki Ho; Wu, Zhichao; Chen, Peng; Zhu, Hua; Ma, Jian-Jie; Cai, Wenfeng; Paul, Christian; Niu, Liang; Fan, Guo-Chang; Wang, Hong-Sheng; Kanisicak, Onur; Xu, Meifeng; Wang, Yigang 2022. CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy. Molecular therapy : the journal of the American Society of Gene Therapy, 30 1, 54-74Li, Huili; Cao, Ting; Ding, Weimin; Liang, Liwen; Fan, Guo-Chang; Qu, Lina; Peng, Tianqing 2022. Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice. Journal of cardiovascular translational research, 15 4, 805-815Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang 2022. Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages. Frontiers in immunology, 13 , 930397Zhang, Mengxiao; Zhong, Huiting; Cao, Ting; Huang, Yifan; Ji, Xiaoyun; Fan, Guo-Chang; Peng, Tianqing 2022. Gamma-Aminobutyrate Transaminase Protects against Lipid Overload-Triggered Cardiac Injury in Mice. International journal of molecular sciences, 23 4, Cui, Shu-Nan; Tan, Hong-Yu; Fan, Guo-Chang 2021. Immunopathological Roles of Neutrophils in Virus Infection and COVID-19. Shock (Augusta, Ga.), , Mu, Xingjiang; Fan, Hongkuan; Wang, Peng; Li, Yutian; Domenico, Karen; Li, Qianqian; Wang, Xiaohong; Essandoh, Kobina; Chen, Jing; Peng, Tianqing; Fan, Guo-Chang 2021. Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal. 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