Education/CredentialsMD/PhD: Ohio State University College of MedicineDoctor of Philosophy : Ohio State UniversityMaster of Science : University of CincinnatiBS: University of Notre Dame (Pre-professional Sciences) Contact Information Research InterestsI studied roles of the complement system in the pathogenesis of F. tularensis. This deadly bacterium is given the highest research priority classification by the CDC as a Category A Select Agent. Most successful human pathogens have evolved molecular mechanisms to subvert, inactivate, or exploit proteins of the complement system. Working in biosafety level 2 and 3 laboratories, my dissertation project was fourfold: 1) to identify complement components activated by specific bacterial surface moieties expre... Abstract Publications Khodoun, M.V., Kucuk, Z.Y., Strait, R.T., Krishnamurthy, D., Janek, K., Clay, C.D., Morris, S.C. and Finkelman, F.D. 2013. Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis Allergy and Clinical Immunology, 132(6) , 1375Mohapatra, N.P., Soni, S., Rajaram, M.V., Dang, P.M.C., Reilly, T.J., El-Benna, J., Clay, C.D., Schlesinger, L.S. and Gunn, J.S. 2010. Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes The Journal of Immunology, 184(9) , 5141Cremer, T.J., Ravneberg, D.H., Clay, C.D., Piper-Hunter, M.G., Marsh, C.B., Elton, T.S., Gunn, J.S., Amer, A., Kanneganti, T.D., Schlesinger, L.S. and Butchar, J.P. 2009. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response PloS one, 4(12) , 8508
Research InterestsI studied roles of the complement system in the pathogenesis of F. tularensis. This deadly bacterium is given the highest research priority classification by the CDC as a Category A Select Agent. Most successful human pathogens have evolved molecular mechanisms to subvert, inactivate, or exploit proteins of the complement system. Working in biosafety level 2 and 3 laboratories, my dissertation project was fourfold: 1) to identify complement components activated by specific bacterial surface moieties expre...
Abstract Publications Khodoun, M.V., Kucuk, Z.Y., Strait, R.T., Krishnamurthy, D., Janek, K., Clay, C.D., Morris, S.C. and Finkelman, F.D. 2013. Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis Allergy and Clinical Immunology, 132(6) , 1375Mohapatra, N.P., Soni, S., Rajaram, M.V., Dang, P.M.C., Reilly, T.J., El-Benna, J., Clay, C.D., Schlesinger, L.S. and Gunn, J.S. 2010. Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes The Journal of Immunology, 184(9) , 5141Cremer, T.J., Ravneberg, D.H., Clay, C.D., Piper-Hunter, M.G., Marsh, C.B., Elton, T.S., Gunn, J.S., Amer, A., Kanneganti, T.D., Schlesinger, L.S. and Butchar, J.P. 2009. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response PloS one, 4(12) , 8508
Khodoun, M.V., Kucuk, Z.Y., Strait, R.T., Krishnamurthy, D., Janek, K., Clay, C.D., Morris, S.C. and Finkelman, F.D. 2013. Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis Allergy and Clinical Immunology, 132(6) , 1375Mohapatra, N.P., Soni, S., Rajaram, M.V., Dang, P.M.C., Reilly, T.J., El-Benna, J., Clay, C.D., Schlesinger, L.S. and Gunn, J.S. 2010. Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes The Journal of Immunology, 184(9) , 5141Cremer, T.J., Ravneberg, D.H., Clay, C.D., Piper-Hunter, M.G., Marsh, C.B., Elton, T.S., Gunn, J.S., Amer, A., Kanneganti, T.D., Schlesinger, L.S. and Butchar, J.P. 2009. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response PloS one, 4(12) , 8508