Education/CredentialsPostdoctoral Research Associate: University of OxfordDoctoral Degree: Virginia Polytechnic Institute & State University (Genetics) Contact Information Medical Sciences Building 4260 Office 513-558-6156 Email zhangtl@ucmail.uc.edu Research InterestsCells, working machines in our body, respond to environmental signals (e.g. food, hormone, and infection, etc.) and make critical decisions such as proliferation, differentiation, defense, or even death. The decision makings of cells are carried out by their molecular control networks. Although no single molecule is directing the cellular behaviors by itself, the dynamical properties emerging from the interaction between the control molecules serve as clear commands to the cells. ... Peer Reviewed Publications Kalantzaki M, Kitamura E, Zhang T, Mino A, Novak B, Tanaka T 2015. Kinetochore microtubule error correction is driven by differentially regulated interaction modes Nat Cell Biol, online, Sero J, Sailem H, Ardy R, Almuttaqi H, Zhang T, Bakal C 2015. Cell shape and the microenvironment regulate nuclear translocation of NF-kB in breast epithelial and tumor cells. Mol Syst Biol, online, Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA 2013. The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell, 52 , 393-405Tuck C, Zhang T, Potapova T, Malumbres M, Novak B 2013. Robust mitotic entry is ensured by a latching switch. Biol Open, 2 , 924-31Zhang T, Oliveira RA, Schmierer B, Novak B 2013. Dynamical scenarios for chromosome bi-orientation. Biophys J, 104 , 2595-606Zhang T, TYson JJ, Novak B 2013. Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts Proc Natl Acad Sci USA, 110 , 20539-44Barr A, Zhang T, Novak B, Bakal C . Systemic characterization of G1/S transition. , , Lossaint G, Bacevic K, Zhang T, Fraillery D, Charrier-Savournin F, Piette J, Fisher D, Dulic V. . Output of a reciprocally regulated Chk1-p21 network controls cell fate after DNA damage-induced G2 arrest. , , Zhang T, Kalantzaki M, Kitamura E, Novak B, Tanaka T . An improved dynamical model of chromosome bi-orientation. , , Zhang T, Novak B, Tyson JJ . Integrative analysis of cell cycle control in mammalian cells. , ,
Research InterestsCells, working machines in our body, respond to environmental signals (e.g. food, hormone, and infection, etc.) and make critical decisions such as proliferation, differentiation, defense, or even death. The decision makings of cells are carried out by their molecular control networks. Although no single molecule is directing the cellular behaviors by itself, the dynamical properties emerging from the interaction between the control molecules serve as clear commands to the cells. ...
Peer Reviewed Publications Kalantzaki M, Kitamura E, Zhang T, Mino A, Novak B, Tanaka T 2015. Kinetochore microtubule error correction is driven by differentially regulated interaction modes Nat Cell Biol, online, Sero J, Sailem H, Ardy R, Almuttaqi H, Zhang T, Bakal C 2015. Cell shape and the microenvironment regulate nuclear translocation of NF-kB in breast epithelial and tumor cells. Mol Syst Biol, online, Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA 2013. The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell, 52 , 393-405Tuck C, Zhang T, Potapova T, Malumbres M, Novak B 2013. Robust mitotic entry is ensured by a latching switch. Biol Open, 2 , 924-31Zhang T, Oliveira RA, Schmierer B, Novak B 2013. Dynamical scenarios for chromosome bi-orientation. Biophys J, 104 , 2595-606Zhang T, TYson JJ, Novak B 2013. Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts Proc Natl Acad Sci USA, 110 , 20539-44Barr A, Zhang T, Novak B, Bakal C . Systemic characterization of G1/S transition. , , Lossaint G, Bacevic K, Zhang T, Fraillery D, Charrier-Savournin F, Piette J, Fisher D, Dulic V. . Output of a reciprocally regulated Chk1-p21 network controls cell fate after DNA damage-induced G2 arrest. , , Zhang T, Kalantzaki M, Kitamura E, Novak B, Tanaka T . An improved dynamical model of chromosome bi-orientation. , , Zhang T, Novak B, Tyson JJ . Integrative analysis of cell cycle control in mammalian cells. , ,
Kalantzaki M, Kitamura E, Zhang T, Mino A, Novak B, Tanaka T 2015. Kinetochore microtubule error correction is driven by differentially regulated interaction modes Nat Cell Biol, online, Sero J, Sailem H, Ardy R, Almuttaqi H, Zhang T, Bakal C 2015. Cell shape and the microenvironment regulate nuclear translocation of NF-kB in breast epithelial and tumor cells. Mol Syst Biol, online, Cundell MJ, Bastos RN, Zhang T, Holder J, Gruneberg U, Novak B, Barr FA 2013. The BEG (PP2A-B55/ENSA/Greatwall) pathway ensures cytokinesis follows chromosome separation. Mol Cell, 52 , 393-405Tuck C, Zhang T, Potapova T, Malumbres M, Novak B 2013. Robust mitotic entry is ensured by a latching switch. Biol Open, 2 , 924-31Zhang T, Oliveira RA, Schmierer B, Novak B 2013. Dynamical scenarios for chromosome bi-orientation. Biophys J, 104 , 2595-606Zhang T, TYson JJ, Novak B 2013. Role for regulated phosphatase activity in generating mitotic oscillations in Xenopus cell-free extracts Proc Natl Acad Sci USA, 110 , 20539-44Barr A, Zhang T, Novak B, Bakal C . Systemic characterization of G1/S transition. , , Lossaint G, Bacevic K, Zhang T, Fraillery D, Charrier-Savournin F, Piette J, Fisher D, Dulic V. . Output of a reciprocally regulated Chk1-p21 network controls cell fate after DNA damage-induced G2 arrest. , , Zhang T, Kalantzaki M, Kitamura E, Novak B, Tanaka T . An improved dynamical model of chromosome bi-orientation. , , Zhang T, Novak B, Tyson JJ . Integrative analysis of cell cycle control in mammalian cells. , ,