Education/CredentialsFellowship: Childrens Hospital Research Foundation (Postdoctoral )Doctoral Degree: University of Cincinnati College of Medicine (Developmental Biology)Bachelor's Degree: Cornell University, College of Agriculture and Life SciencesFellowship: Shriners Hospitals for Children (Research Fellowship ) Contact Information Medical Sciences Building 2463 Office 513-558-4617 Email suppdm@ucmail.uc.edu Research InterestsThe purpose of my research is to enhance the performance of cultured skin substitutes for the healing of burns and other skin wounds. Cultured skin substitutes have been used at the Shriners Burns Hospital and the University of Cincinnati as an adjunctive treatment for large burn wounds. Although significant improvements over recent years have led to better clinical outcomes, cultured skin substitutes are still limited by deficiencies in anatomy and physiology compared to native skin autograft. Using the ... Peer Reviewed Publications Blackstone, Britani N; Malara, Megan M; Baumann, Molly E; McFarland, Kevin L; Supp, Dorothy M; Powell, Heather M 2023. Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation. Bioengineering (Basel, Switzerland), 10 7, Carney, Bonnie C; Bailey, John K; Powell, Heather M; Supp, Dorothy M; Travis, Taryn E 2023. Scar Management and Dyschromia: A Summary Report from the 2021 American Burn Association State of the Science Meeting. Journal of burn care & research : official publication of the American Burn Association, 44 3, 535-545Hahn, Jennifer M; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2023. A Role for Vitamin D and the Vitamin D Receptor in Keloid Disorder. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Bergmann, C. B.; McReynolds, C. B.; Wan, D.; Singh, N.; Goetzman, H.; Caldwell, C. C.; Supp, D. M.; Hammock, B. D. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury Proc Natl Acad Sci U S A, 119 13 , e2120691119Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M; Hammock, Bruce D 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences of the United States of America, 119 13, e2120691119Burmeister, David M; Supp, Dorothy M; Clark, Richard A; Tredget, Edward E; Powell, Heather M; Enkhbaatar, Perenlei; Bohannon, Julia K; Cancio, Leopoldo C; Hill, David M; Nygaard, Rachel M 2022. Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group. Journal of burn care & research : official publication of the American Burn Association, 43 5, 1032-1041Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2022. Myofibroblasts Are Not Characteristic Features of Keloid Lesions. Plastic and reconstructive surgery. Global open, 10 11, e4680Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Powell, H. M. 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample STAR Protoc, 3 1 , 101172Supp, Dorothy M; Hahn, Jennifer M; Combs, Kelly A; McFarland, Kevin L; Powell, Heather M 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample. STAR protocols, 3 1, 101172Baumann, Molly E; DeBruler, Danielle M; Blackstone, Britani N; Coffey, Rebecca A; Boyce, Steven T; Supp, Dorothy M; Bailey, J Kevin; Powell, Heather M 2021. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties. Burns : journal of the International Society for Burn Injuries, 47 2, 466-478Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports, 11 1, 16555Gibson, A. L. F.; Carney, B. C.; Cuttle, L.; Andrews, C. J.; Kowalczewski, C. J.; Liu, A.; Powell, H. M.; Stone, R.; Supp, D. M.; Singer, A. J.; Shupp, J. W.; Stalter, L.; Moffatt, L. T. 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? J Burn Care Res, 42 1 , 98-109Gibson, Angela L F; Carney, Bonnie C; Cuttle, Leila; Andrews, Christine J; Kowalczewski, Christine J; Liu, Aiping; Powell, Heather M; Stone, Randolph; Supp, Dorothy M; Singer, Adam J; Shupp, Jeffrey W; Stalter, Lily; Moffatt, Lauren T 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? Journal of burn care & research : official publication of the American Burn Association, 42 1, 98-109Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Anness, M. C.; Supp, D. M. 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin Wound Repair Regen, 29 5 , 777-791Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Anness, Meridith C; Supp, Dorothy M 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 29 5, 777-791Powell, Heather M; Supp, Dorothy M; Bailey, J Kevin; Baumann, Molly E 2021. Response to the Letter to the Editor: Fractional CO2 laser ablation of porcine burn scars after grafting: Is deeper better? Burns : journal of the International Society for Burn Injuries, 47 2, 494-495Ruiz-Torres, S.; Brusadelli, M. G.; Witte, D. P.; Wikenheiser-Brokamp, K. A.; Sauter, S.; Nelson, A. S.; Sertorio, M.; Chlon, T. M.; Lane, A.; Mehta, P. A.; Myers, K. C.; Bedard, M. C.; Pal, B.; Supp, D. M.; Lambert, P. F.; Komurov, K.; Kovacic, M. B.; Davies, S. M.; Wells, S. I. 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin Cell Stem Cell, 28 3 , 424-435.e6Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Baumann, M. E.; DeBruler, D. M.; Blackstone, B. N.; Coffey, R. A.; Boyce, S. T.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2020. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties Burns, 102 3-4 , 287-297Blackstone, B. N.; Malara, M. M.; Baumann, M. E.; McFarland, K. L.; Supp, D. M.; Powell, H. M. 2020. Fractional CO2 laser micropatterning of cell-seeded electrospun collagen scaffolds enables rete ridge formation in 3D engineered skin Acta Biomater, 102 3-4 , 287-297Boyce, S. T.; Supp, D. M.; Lloyd, C. M. 2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Isogeneic Cell Types Tissue Eng Part A, 26 3-4 , 214-224DeBruler, D. M.; Baumann, M. E.; Zbinden, J. C.; Blackstone, B. N.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy Adv Wound Care (New Rochelle), 9 8 , 453-61DeBruler, Danielle M; Baumann, Molly E; Zbinden, Jacob C; Blackstone, Britani N; Bailey, John Kevin; Supp, Dorothy M; Powell, Heather M 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy. Advances in wound care, 9 8, 453-461Malara, M. M.; Blackstone, B. N.; Baumann, M. E.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo Tissue Eng Part A, 26 21-22 , 1138-1146Malara, Megan M; Blackstone, Britani N; Baumann, Molly E; Bailey, J Kevin; Supp, Dorothy M; Powell, Heather M 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo. Tissue engineering. Part A, 26 21-22, 1138-1146Satish, L.; Evdokiou, A.; Geletu, E.; Hahn, J. M.; Supp, D. M. 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes Burns Trauma, 8 4 , tkz007Satish, Latha; Evdokiou, Alexander; Geletu, Eleni; Hahn, Jennifer M; Supp, Dorothy M 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes. Burns & trauma, 8 , tkz007Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Supp, D. M.; Hahn, J. M.; Lloyd, C. M.; Combs, K. A.; Swope, V. B.; Abdel-Malek, Z.; Boyce, S. T. 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo J Burn Care Res, 41 4 , 751-760Supp, Dorothy M; Hahn, Jennifer M; Lloyd, Christopher M; Combs, Kelly A; Swope, Viki B; Abdel-Malek, Zalfa; Boyce, Steven T 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo. Journal of burn care & research : official publication of the American Burn Association, 41 4, 751-760DeBruler, D. M.; Baumann, M. E.; Blackstone, B. N.; Zbinden, J. C.; McFarland, K. L.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plast Reconstr Surg, 143 2 , 310e-321eHahn, J. M.; Combs, K. A.; Lloyd, C. M.; McFarland, K. L.; Boyce, S. T.; Supp, D. M. 2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds PLoS One, 14 3 , e0213325Supp, D. M. 2019. Animal Models for Studies of Keloid Scarring Adv Wound Care (New Rochelle), 8 2 , 77-89Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Schwentker, A.; Boissy, R. E.; Boyce, S. T.; Powell, H. M.; Lucky, A. W. 2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes Burns, 28 9-10 , 1242-1256Supp, Dorothy M 2019. Animal Models for Studies of Keloid Scarring. Advances in wound care, 8 2, 77-89Bailey, J. K.; Blackstone, B. N.; DeBruler, D. M.; Kim, J. Y.; Baumann, M. E.; McFarland, K. L.; Imeokparia, F. O.; Supp, D. M.; Powell, H. M. 2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser Acta Biomater, 50 1 , 78-87Blackstone, B. N.; Hahn, J. M.; McFarland, K. L.; DeBruler, D. M.; Supp, D. M.; Powell, H. M. 2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro and post-grafting Acta Biomater, 80 17 , 247-257DeBruler, D. M.; Zbinden, J. C.; Baumann, M. E.; Blackstone, B. N.; Malara, M. M.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Early cessation of pressure garment therapy results in scar contraction and thickening J Burn Care Res, 13 6 , e0197558DeBruler, D. M.; Blackstone, B. N.; McFarland, K. L.; Baumann, M. E.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2018. Effect of skin graft thickness on scar development in a porcine burn model J Burn Care Res, 13 17 , 10Malara, M. M.; Kim, J. Y.; Clark, J. A.; Blackstone, B. N.; Ruegsegger, M. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use and Repeated Laundering J Burn Care Res, 39 4 , 562-571Blackstone, B. N.; Kim, J. Y.; McFarland, K. L.; Sen, C. K.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair Regen., 25 4 , 618-631Boyce, S. T.; Lloyd, C. M.; Kleiner, M. C.; Swope, V. B.; Abdel-Malek, Z.; Supp, D. M. 2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes Acta Biomater, 30 6 , 531-540DeBruler, D. M.; Blackstone, B. N.; Baumann, M. E.; McFarland, K. L.; Wulff, B. C.; Wilgus, T. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of scars Acta Biomater, 49 7 , 675-685Hahn, J. M.; Supp, D. M. 2017. Abnormal expression of the vitamin D receptor in keloid scars Acta Biomater, 43 7 , 1506-1515Sethuraman, S. A.; Gottschlich, M. M.; Supp, D. M.; Khoury, J.; Kagan, R. J. 2017. Vitamin D biomarkers associated with abnormal scar formation in pediatric burn patients Acta Biomater, 1 1 , 78-87Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Supp, D. M. 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-á1 Burns Trauma, 4 2 , 30Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Supp, Dorothy M 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns & trauma, 4 1, 30Kim, J. Y.; Dunham, D. M.; Supp, D. M.; Sen, C. K.; Powell, H. M. 2016. Novel burn device for rapid, reproducible burn wound generation Plast Reconstr Surg Glob Open, 42 2 , 384-391Supp, D. M.; Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Lee, K. S.; Inceoglu, B.; Wan, D.; Boyce, S. T.; Hammock, B. D. 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes Plast Reconstr Surg Glob Open, 4 12 , e1151Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Lee, Kin Sing Stephen; Inceoglu, Bora; Wan, Debin; Boyce, Steven T; Hammock, Bruce D 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plastic and reconstructive surgery. Global open, 4 12, e1151Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M 2015. Burn Scar Biomechanics Following Pressure Garment Therapy. Plastic and reconstructive surgery, , Alexander, J Wesley; Supp, Dorothy M 2014. Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection. Advances in wound care, 3 11, 682-690Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, , Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5Supp, Dorothy M 2012. Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes. Advances in wound care, 1 2, 63-68Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T 2012. LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, 12 , e19Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plastic and reconstructive surgery, 129 6, 1259-71Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4. Burns : journal of the International Society for Burn Injuries, 35 7, 949-55Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93Powell, Heather M; Supp, Dorothy M; Boyce, Steven T 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials, 29 7, 834-43Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman 2007. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1545-51Supp, Dorothy M 2007. Gene therapy to fight infection in skin transplants. Pharmacogenomics, 8 5, 483-6Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns : journal of the International Society for Burn Injuries, 32 2, 135-8Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. The Journal of investigative dermatology, 125 6, 1286-301Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns : journal of the International Society for Burn Injuries, 30 7, 643-8Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 8, 797-804Supp, D M; Supp, A P; Bell, S M; Boyce, S T 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. The Journal of investigative dermatology, 114 1, 5-13Boyce S.;Lloyd C.;Kleiner M.;Swope V.;Abdel-Malek Z.;Supp D. 11-01-2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in d Pigment Cell and Melanoma Research, 30 6, 531-540Hahn J.;Supp D. 11-01-2017. Abnormal expression of the vitamin D receptor in keloid scars Burns, 43 7, 1506-1515Forouzandeh F.;Jalili R.;Hartwell R.;Allan S.;Boyce S.;Supp D.;Ghahary A. 11-01-2010. Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineere Wound Repair and Regeneration, 18 6, 614-623Blackstone B.;Hahn J.;McFarland K.;DeBruler D.;Supp D.;Powell H. 10-15-2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro Acta Biomaterialia, 80 , 247-257Supp D.M.;Hahn J.M.;Combs K.A.;McFarland K.L.;Schwentker A.;Boissy R.E.;Boyce S.T.;Powell H.M.;Lucky A.W. 09-01-2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Forma Cell Transplantation, 28 9-10, 1242-1256DeBruler D.;Blackstone B.;Baumann M.;McFarland K.;Wulff B.;Wilgus T.;Bailey J.;Supp D.;Powell H. 09-01-2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO<inf>2& Lasers in Surgery and Medicine, 49 7, 675-685Lander J.;Supp D.;He H.;Martin L.;Chen X.;Weirauch M.;Boyce S.;Kopan R. 09-01-2017. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensi PLoS ONE, 12 9, Blackstone B.;Kim J.;McFarland K.;Sen C.;Supp D.;Bailey J.;Powell H. 07-01-2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair and Regeneration, 25 4, 618-631Malara M.;Kim J.;Clark J.;Blackstone B.;Ruegsegger M.;Bailey J.;Supp D.;Powell H. 06-13-2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use Journal of Burn Care and Research, 39 4, 562-571DeBruler D.;Blackstone B.;McFarland K.;Baumann M.;Supp D.;Bailey J.;Powell H. 06-01-2018. Effect of skin graft thickness on scar development in a porcine burn model Burns, 44 4, 917-930DeBruler D.;Zbinden J.;Baumann M.;Blackstone B.;Malara M.;Bailey J.;Supp D.;Powell H. 06-01-2018. Early cessation of pressure garment therapy results in scar contraction and thickening PLoS ONE, 13 6, Kalyanaraman B.;Supp D.;Boyce S. 05-01-2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusio Tissue Engineering - Part A., 14 5, 583-593Supp D.;Boyce S. 04-19-2016. Bioengineering of human skin substitutes Tissue Engineering and Artificial Organs, , 715-731Supp D. 04-01-2011. Skin substitutes for burn wound healing: Current and future approaches Expert Review of Dermatology, 6 2, 217-227Hahn J.M.;Combs K.A.;Lloyd C.M.;McFarland K.L.;Boyce S.T.;Supp D.M. 03-01-2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting PLoS ONE, 14 3, Kim J.;Dunham D.;Supp D.;Sen C.;Powell H. 03-01-2016. Novel burn device for rapid, reproducible burn wound generation Burns, 42 2, 384-391Boyce S.T.;Supp D.M.;Lloyd C.M. 02-01-2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Tissue Engineering - Part A, 26 3-4, 214-224Debruler D.;Baumann M.;Blackstone B.;Zbinden J.;McFarland K.;Bailey J.;Supp D.;Powell H. 02-01-2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plastic and Reconstructive Surgery, 143 2, 310e-321eSupp D. 02-01-2019. Animal Models for Studies of Keloid Scarring Advances in Wound Care, 8 2, 77-89Abdel-Malek Z.;Supp D. 02-01-2008. ?-Defensin 3: A novel and unexpected key that unlocks the melanocortin 1 receptor Pigment Cell and Melanoma Research, 21 1, 7-8Supp D.;Neely A. 02-01-2008. Cutaneous antimicrobial gene therapy: Engineering human skin replacements to combat wound infection Expert Review of Dermatology, 3 1, 73-84Blackstone B.;Malara M.;Baumann M.;McFarland K.;Supp D.;Powell H. 01-15-2020. Fractional CO<inf>2</inf> laser micropatterning of cell-seeded electrospun collagen scaf Acta Biomaterialia, 102 , 287-297Baumann M.E.;Blackstone B.N.;Malara M.M.;Clairmonte I.A.;Supp D.M.;Bailey J.K.;Powell H.M. 01-01-2019. Fractional CO<inf>2</inf> laser ablation of porcine burn scars after grafting: Is deeper Burns, , Bailey J.;Blackstone B.;DeBruler D.;Kim J.;Baumann M.;McFarland K.;Imeokparia F.;Supp D.;Powell H. 01-01-2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig Lasers in Surgery and Medicine, 50 1, 78-87Boyce S.;Supp D. 01-01-2016. Biologic Skin Substitutes Skin Tissue Engineering and Regenerative Medicine, , 211-238Supp D.M.;Hahn J.M.;McFarland K.L.;Combs K.A.;Lee K.S.S.;Inceoglu B.;Wan D.;Boyce S.T.;Hammock B.D. 01-01-2016. Soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acid treatment improve vascularization Plastic and Reconstructive Surgery - Global Open, 4 12, Swope V.B.;Jameson J.A.;McFarland K.L.;Supp D.M.;Miller W.E.;McGraw D.W.;Patel M.A.;Nix M.A.;Millhauser G.L.;Babcock G.F.;Abdel-Malek Z.A. 01-01-2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti s Journal of Investigative Dermatology, 132 9, 2255-2262Kadekaro A.L.;Leachman S.;Kavanagh R.J.;Swope V.;Cassidy P.;Supp D.;Sartor M.;Schwemberger S.;Babcock G.;Wakamatsu K.;Ito S.;Koshoffer A.;Boissy R.E.;Manga P.;Sturm R.A.;Abdel-Malek Z.A. 01-01-2010. Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to FASEB Journal, 24 10, 3850-3860Supp D.;Boyce S. 01-01-2007. Bioengineering of human skin substitutes Tissue Engineering, , 275-291Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M . Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M . Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association, 32 4, 498-508McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 16 4, 534-41Smiley, Andrea K; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N; Supp, Dorothy M . Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity. Journal of burn care & research : official publication of the American Burn Association, 28 1, 127-32Supp, Andrew P; Neely, Alice N; Supp, Dorothy M; Warden, Glenn D; Boyce, Steven T . Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 26 3, 238-46Supp, D M; Bell, S M; Morgan, J R; Boyce, S T . Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 8 1, 26-35Supp, Dorothy M; Boyce, Steven T . Engineered skin substitutes: practices and potentials. Clinics in dermatology, 23 4, 403-12Supp, Dorothy M; Boyce, Steven T . Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. The Journal of burn care & rehabilitation, 23 1, 10-20Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Glaser, Kathryn . Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes. Journal of burn care & research : official publication of the American Burn Association, 35 1, 84-92Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T . Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 25 4, 337-45
Research InterestsThe purpose of my research is to enhance the performance of cultured skin substitutes for the healing of burns and other skin wounds. Cultured skin substitutes have been used at the Shriners Burns Hospital and the University of Cincinnati as an adjunctive treatment for large burn wounds. Although significant improvements over recent years have led to better clinical outcomes, cultured skin substitutes are still limited by deficiencies in anatomy and physiology compared to native skin autograft. Using the ...
Peer Reviewed Publications Blackstone, Britani N; Malara, Megan M; Baumann, Molly E; McFarland, Kevin L; Supp, Dorothy M; Powell, Heather M 2023. Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation. Bioengineering (Basel, Switzerland), 10 7, Carney, Bonnie C; Bailey, John K; Powell, Heather M; Supp, Dorothy M; Travis, Taryn E 2023. Scar Management and Dyschromia: A Summary Report from the 2021 American Burn Association State of the Science Meeting. Journal of burn care & research : official publication of the American Burn Association, 44 3, 535-545Hahn, Jennifer M; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2023. A Role for Vitamin D and the Vitamin D Receptor in Keloid Disorder. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Bergmann, C. B.; McReynolds, C. B.; Wan, D.; Singh, N.; Goetzman, H.; Caldwell, C. C.; Supp, D. M.; Hammock, B. D. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury Proc Natl Acad Sci U S A, 119 13 , e2120691119Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M; Hammock, Bruce D 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences of the United States of America, 119 13, e2120691119Burmeister, David M; Supp, Dorothy M; Clark, Richard A; Tredget, Edward E; Powell, Heather M; Enkhbaatar, Perenlei; Bohannon, Julia K; Cancio, Leopoldo C; Hill, David M; Nygaard, Rachel M 2022. Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group. Journal of burn care & research : official publication of the American Burn Association, 43 5, 1032-1041Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2022. Myofibroblasts Are Not Characteristic Features of Keloid Lesions. Plastic and reconstructive surgery. Global open, 10 11, e4680Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Powell, H. M. 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample STAR Protoc, 3 1 , 101172Supp, Dorothy M; Hahn, Jennifer M; Combs, Kelly A; McFarland, Kevin L; Powell, Heather M 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample. STAR protocols, 3 1, 101172Baumann, Molly E; DeBruler, Danielle M; Blackstone, Britani N; Coffey, Rebecca A; Boyce, Steven T; Supp, Dorothy M; Bailey, J Kevin; Powell, Heather M 2021. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties. Burns : journal of the International Society for Burn Injuries, 47 2, 466-478Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports, 11 1, 16555Gibson, A. L. F.; Carney, B. C.; Cuttle, L.; Andrews, C. J.; Kowalczewski, C. J.; Liu, A.; Powell, H. M.; Stone, R.; Supp, D. M.; Singer, A. J.; Shupp, J. W.; Stalter, L.; Moffatt, L. T. 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? J Burn Care Res, 42 1 , 98-109Gibson, Angela L F; Carney, Bonnie C; Cuttle, Leila; Andrews, Christine J; Kowalczewski, Christine J; Liu, Aiping; Powell, Heather M; Stone, Randolph; Supp, Dorothy M; Singer, Adam J; Shupp, Jeffrey W; Stalter, Lily; Moffatt, Lauren T 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? Journal of burn care & research : official publication of the American Burn Association, 42 1, 98-109Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Anness, M. C.; Supp, D. M. 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin Wound Repair Regen, 29 5 , 777-791Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Anness, Meridith C; Supp, Dorothy M 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 29 5, 777-791Powell, Heather M; Supp, Dorothy M; Bailey, J Kevin; Baumann, Molly E 2021. Response to the Letter to the Editor: Fractional CO2 laser ablation of porcine burn scars after grafting: Is deeper better? Burns : journal of the International Society for Burn Injuries, 47 2, 494-495Ruiz-Torres, S.; Brusadelli, M. G.; Witte, D. P.; Wikenheiser-Brokamp, K. A.; Sauter, S.; Nelson, A. S.; Sertorio, M.; Chlon, T. M.; Lane, A.; Mehta, P. A.; Myers, K. C.; Bedard, M. C.; Pal, B.; Supp, D. M.; Lambert, P. F.; Komurov, K.; Kovacic, M. B.; Davies, S. M.; Wells, S. I. 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin Cell Stem Cell, 28 3 , 424-435.e6Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Baumann, M. E.; DeBruler, D. M.; Blackstone, B. N.; Coffey, R. A.; Boyce, S. T.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2020. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties Burns, 102 3-4 , 287-297Blackstone, B. N.; Malara, M. M.; Baumann, M. E.; McFarland, K. L.; Supp, D. M.; Powell, H. M. 2020. Fractional CO2 laser micropatterning of cell-seeded electrospun collagen scaffolds enables rete ridge formation in 3D engineered skin Acta Biomater, 102 3-4 , 287-297Boyce, S. T.; Supp, D. M.; Lloyd, C. M. 2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Isogeneic Cell Types Tissue Eng Part A, 26 3-4 , 214-224DeBruler, D. M.; Baumann, M. E.; Zbinden, J. C.; Blackstone, B. N.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy Adv Wound Care (New Rochelle), 9 8 , 453-61DeBruler, Danielle M; Baumann, Molly E; Zbinden, Jacob C; Blackstone, Britani N; Bailey, John Kevin; Supp, Dorothy M; Powell, Heather M 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy. Advances in wound care, 9 8, 453-461Malara, M. M.; Blackstone, B. N.; Baumann, M. E.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo Tissue Eng Part A, 26 21-22 , 1138-1146Malara, Megan M; Blackstone, Britani N; Baumann, Molly E; Bailey, J Kevin; Supp, Dorothy M; Powell, Heather M 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo. Tissue engineering. Part A, 26 21-22, 1138-1146Satish, L.; Evdokiou, A.; Geletu, E.; Hahn, J. M.; Supp, D. M. 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes Burns Trauma, 8 4 , tkz007Satish, Latha; Evdokiou, Alexander; Geletu, Eleni; Hahn, Jennifer M; Supp, Dorothy M 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes. Burns & trauma, 8 , tkz007Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Supp, D. M.; Hahn, J. M.; Lloyd, C. M.; Combs, K. A.; Swope, V. B.; Abdel-Malek, Z.; Boyce, S. T. 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo J Burn Care Res, 41 4 , 751-760Supp, Dorothy M; Hahn, Jennifer M; Lloyd, Christopher M; Combs, Kelly A; Swope, Viki B; Abdel-Malek, Zalfa; Boyce, Steven T 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo. Journal of burn care & research : official publication of the American Burn Association, 41 4, 751-760DeBruler, D. M.; Baumann, M. E.; Blackstone, B. N.; Zbinden, J. C.; McFarland, K. L.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plast Reconstr Surg, 143 2 , 310e-321eHahn, J. M.; Combs, K. A.; Lloyd, C. M.; McFarland, K. L.; Boyce, S. T.; Supp, D. M. 2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds PLoS One, 14 3 , e0213325Supp, D. M. 2019. Animal Models for Studies of Keloid Scarring Adv Wound Care (New Rochelle), 8 2 , 77-89Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Schwentker, A.; Boissy, R. E.; Boyce, S. T.; Powell, H. M.; Lucky, A. W. 2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes Burns, 28 9-10 , 1242-1256Supp, Dorothy M 2019. Animal Models for Studies of Keloid Scarring. Advances in wound care, 8 2, 77-89Bailey, J. K.; Blackstone, B. N.; DeBruler, D. M.; Kim, J. Y.; Baumann, M. E.; McFarland, K. L.; Imeokparia, F. O.; Supp, D. M.; Powell, H. M. 2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser Acta Biomater, 50 1 , 78-87Blackstone, B. N.; Hahn, J. M.; McFarland, K. L.; DeBruler, D. M.; Supp, D. M.; Powell, H. M. 2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro and post-grafting Acta Biomater, 80 17 , 247-257DeBruler, D. M.; Zbinden, J. C.; Baumann, M. E.; Blackstone, B. N.; Malara, M. M.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Early cessation of pressure garment therapy results in scar contraction and thickening J Burn Care Res, 13 6 , e0197558DeBruler, D. M.; Blackstone, B. N.; McFarland, K. L.; Baumann, M. E.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2018. Effect of skin graft thickness on scar development in a porcine burn model J Burn Care Res, 13 17 , 10Malara, M. M.; Kim, J. Y.; Clark, J. A.; Blackstone, B. N.; Ruegsegger, M. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use and Repeated Laundering J Burn Care Res, 39 4 , 562-571Blackstone, B. N.; Kim, J. Y.; McFarland, K. L.; Sen, C. K.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair Regen., 25 4 , 618-631Boyce, S. T.; Lloyd, C. M.; Kleiner, M. C.; Swope, V. B.; Abdel-Malek, Z.; Supp, D. M. 2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes Acta Biomater, 30 6 , 531-540DeBruler, D. M.; Blackstone, B. N.; Baumann, M. E.; McFarland, K. L.; Wulff, B. C.; Wilgus, T. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of scars Acta Biomater, 49 7 , 675-685Hahn, J. M.; Supp, D. M. 2017. Abnormal expression of the vitamin D receptor in keloid scars Acta Biomater, 43 7 , 1506-1515Sethuraman, S. A.; Gottschlich, M. M.; Supp, D. M.; Khoury, J.; Kagan, R. J. 2017. Vitamin D biomarkers associated with abnormal scar formation in pediatric burn patients Acta Biomater, 1 1 , 78-87Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Supp, D. M. 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-á1 Burns Trauma, 4 2 , 30Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Supp, Dorothy M 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns & trauma, 4 1, 30Kim, J. Y.; Dunham, D. M.; Supp, D. M.; Sen, C. K.; Powell, H. M. 2016. Novel burn device for rapid, reproducible burn wound generation Plast Reconstr Surg Glob Open, 42 2 , 384-391Supp, D. M.; Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Lee, K. S.; Inceoglu, B.; Wan, D.; Boyce, S. T.; Hammock, B. D. 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes Plast Reconstr Surg Glob Open, 4 12 , e1151Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Lee, Kin Sing Stephen; Inceoglu, Bora; Wan, Debin; Boyce, Steven T; Hammock, Bruce D 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plastic and reconstructive surgery. Global open, 4 12, e1151Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M 2015. Burn Scar Biomechanics Following Pressure Garment Therapy. Plastic and reconstructive surgery, , Alexander, J Wesley; Supp, Dorothy M 2014. Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection. Advances in wound care, 3 11, 682-690Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, , Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5Supp, Dorothy M 2012. Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes. Advances in wound care, 1 2, 63-68Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T 2012. LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, 12 , e19Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plastic and reconstructive surgery, 129 6, 1259-71Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4. Burns : journal of the International Society for Burn Injuries, 35 7, 949-55Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93Powell, Heather M; Supp, Dorothy M; Boyce, Steven T 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials, 29 7, 834-43Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman 2007. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1545-51Supp, Dorothy M 2007. Gene therapy to fight infection in skin transplants. Pharmacogenomics, 8 5, 483-6Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns : journal of the International Society for Burn Injuries, 32 2, 135-8Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. The Journal of investigative dermatology, 125 6, 1286-301Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns : journal of the International Society for Burn Injuries, 30 7, 643-8Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 8, 797-804Supp, D M; Supp, A P; Bell, S M; Boyce, S T 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. The Journal of investigative dermatology, 114 1, 5-13Boyce S.;Lloyd C.;Kleiner M.;Swope V.;Abdel-Malek Z.;Supp D. 11-01-2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in d Pigment Cell and Melanoma Research, 30 6, 531-540Hahn J.;Supp D. 11-01-2017. Abnormal expression of the vitamin D receptor in keloid scars Burns, 43 7, 1506-1515Forouzandeh F.;Jalili R.;Hartwell R.;Allan S.;Boyce S.;Supp D.;Ghahary A. 11-01-2010. Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineere Wound Repair and Regeneration, 18 6, 614-623Blackstone B.;Hahn J.;McFarland K.;DeBruler D.;Supp D.;Powell H. 10-15-2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro Acta Biomaterialia, 80 , 247-257Supp D.M.;Hahn J.M.;Combs K.A.;McFarland K.L.;Schwentker A.;Boissy R.E.;Boyce S.T.;Powell H.M.;Lucky A.W. 09-01-2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Forma Cell Transplantation, 28 9-10, 1242-1256DeBruler D.;Blackstone B.;Baumann M.;McFarland K.;Wulff B.;Wilgus T.;Bailey J.;Supp D.;Powell H. 09-01-2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO<inf>2& Lasers in Surgery and Medicine, 49 7, 675-685Lander J.;Supp D.;He H.;Martin L.;Chen X.;Weirauch M.;Boyce S.;Kopan R. 09-01-2017. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensi PLoS ONE, 12 9, Blackstone B.;Kim J.;McFarland K.;Sen C.;Supp D.;Bailey J.;Powell H. 07-01-2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair and Regeneration, 25 4, 618-631Malara M.;Kim J.;Clark J.;Blackstone B.;Ruegsegger M.;Bailey J.;Supp D.;Powell H. 06-13-2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use Journal of Burn Care and Research, 39 4, 562-571DeBruler D.;Blackstone B.;McFarland K.;Baumann M.;Supp D.;Bailey J.;Powell H. 06-01-2018. Effect of skin graft thickness on scar development in a porcine burn model Burns, 44 4, 917-930DeBruler D.;Zbinden J.;Baumann M.;Blackstone B.;Malara M.;Bailey J.;Supp D.;Powell H. 06-01-2018. Early cessation of pressure garment therapy results in scar contraction and thickening PLoS ONE, 13 6, Kalyanaraman B.;Supp D.;Boyce S. 05-01-2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusio Tissue Engineering - Part A., 14 5, 583-593Supp D.;Boyce S. 04-19-2016. Bioengineering of human skin substitutes Tissue Engineering and Artificial Organs, , 715-731Supp D. 04-01-2011. Skin substitutes for burn wound healing: Current and future approaches Expert Review of Dermatology, 6 2, 217-227Hahn J.M.;Combs K.A.;Lloyd C.M.;McFarland K.L.;Boyce S.T.;Supp D.M. 03-01-2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting PLoS ONE, 14 3, Kim J.;Dunham D.;Supp D.;Sen C.;Powell H. 03-01-2016. Novel burn device for rapid, reproducible burn wound generation Burns, 42 2, 384-391Boyce S.T.;Supp D.M.;Lloyd C.M. 02-01-2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Tissue Engineering - Part A, 26 3-4, 214-224Debruler D.;Baumann M.;Blackstone B.;Zbinden J.;McFarland K.;Bailey J.;Supp D.;Powell H. 02-01-2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plastic and Reconstructive Surgery, 143 2, 310e-321eSupp D. 02-01-2019. Animal Models for Studies of Keloid Scarring Advances in Wound Care, 8 2, 77-89Abdel-Malek Z.;Supp D. 02-01-2008. ?-Defensin 3: A novel and unexpected key that unlocks the melanocortin 1 receptor Pigment Cell and Melanoma Research, 21 1, 7-8Supp D.;Neely A. 02-01-2008. Cutaneous antimicrobial gene therapy: Engineering human skin replacements to combat wound infection Expert Review of Dermatology, 3 1, 73-84Blackstone B.;Malara M.;Baumann M.;McFarland K.;Supp D.;Powell H. 01-15-2020. Fractional CO<inf>2</inf> laser micropatterning of cell-seeded electrospun collagen scaf Acta Biomaterialia, 102 , 287-297Baumann M.E.;Blackstone B.N.;Malara M.M.;Clairmonte I.A.;Supp D.M.;Bailey J.K.;Powell H.M. 01-01-2019. Fractional CO<inf>2</inf> laser ablation of porcine burn scars after grafting: Is deeper Burns, , Bailey J.;Blackstone B.;DeBruler D.;Kim J.;Baumann M.;McFarland K.;Imeokparia F.;Supp D.;Powell H. 01-01-2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig Lasers in Surgery and Medicine, 50 1, 78-87Boyce S.;Supp D. 01-01-2016. Biologic Skin Substitutes Skin Tissue Engineering and Regenerative Medicine, , 211-238Supp D.M.;Hahn J.M.;McFarland K.L.;Combs K.A.;Lee K.S.S.;Inceoglu B.;Wan D.;Boyce S.T.;Hammock B.D. 01-01-2016. Soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acid treatment improve vascularization Plastic and Reconstructive Surgery - Global Open, 4 12, Swope V.B.;Jameson J.A.;McFarland K.L.;Supp D.M.;Miller W.E.;McGraw D.W.;Patel M.A.;Nix M.A.;Millhauser G.L.;Babcock G.F.;Abdel-Malek Z.A. 01-01-2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti s Journal of Investigative Dermatology, 132 9, 2255-2262Kadekaro A.L.;Leachman S.;Kavanagh R.J.;Swope V.;Cassidy P.;Supp D.;Sartor M.;Schwemberger S.;Babcock G.;Wakamatsu K.;Ito S.;Koshoffer A.;Boissy R.E.;Manga P.;Sturm R.A.;Abdel-Malek Z.A. 01-01-2010. Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to FASEB Journal, 24 10, 3850-3860Supp D.;Boyce S. 01-01-2007. Bioengineering of human skin substitutes Tissue Engineering, , 275-291Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M . Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M . Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association, 32 4, 498-508McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 16 4, 534-41Smiley, Andrea K; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N; Supp, Dorothy M . Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity. Journal of burn care & research : official publication of the American Burn Association, 28 1, 127-32Supp, Andrew P; Neely, Alice N; Supp, Dorothy M; Warden, Glenn D; Boyce, Steven T . Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 26 3, 238-46Supp, D M; Bell, S M; Morgan, J R; Boyce, S T . Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 8 1, 26-35Supp, Dorothy M; Boyce, Steven T . Engineered skin substitutes: practices and potentials. Clinics in dermatology, 23 4, 403-12Supp, Dorothy M; Boyce, Steven T . Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. The Journal of burn care & rehabilitation, 23 1, 10-20Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Glaser, Kathryn . Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes. Journal of burn care & research : official publication of the American Burn Association, 35 1, 84-92Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T . Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 25 4, 337-45
Blackstone, Britani N; Malara, Megan M; Baumann, Molly E; McFarland, Kevin L; Supp, Dorothy M; Powell, Heather M 2023. Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation. Bioengineering (Basel, Switzerland), 10 7, Carney, Bonnie C; Bailey, John K; Powell, Heather M; Supp, Dorothy M; Travis, Taryn E 2023. Scar Management and Dyschromia: A Summary Report from the 2021 American Burn Association State of the Science Meeting. Journal of burn care & research : official publication of the American Burn Association, 44 3, 535-545Hahn, Jennifer M; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2023. A Role for Vitamin D and the Vitamin D Receptor in Keloid Disorder. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , Bergmann, C. B.; McReynolds, C. B.; Wan, D.; Singh, N.; Goetzman, H.; Caldwell, C. C.; Supp, D. M.; Hammock, B. D. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury Proc Natl Acad Sci U S A, 119 13 , e2120691119Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M; Hammock, Bruce D 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences of the United States of America, 119 13, e2120691119Burmeister, David M; Supp, Dorothy M; Clark, Richard A; Tredget, Edward E; Powell, Heather M; Enkhbaatar, Perenlei; Bohannon, Julia K; Cancio, Leopoldo C; Hill, David M; Nygaard, Rachel M 2022. Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group. Journal of burn care & research : official publication of the American Burn Association, 43 5, 1032-1041Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M 2022. Myofibroblasts Are Not Characteristic Features of Keloid Lesions. Plastic and reconstructive surgery. Global open, 10 11, e4680Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Powell, H. M. 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample STAR Protoc, 3 1 , 101172Supp, Dorothy M; Hahn, Jennifer M; Combs, Kelly A; McFarland, Kevin L; Powell, Heather M 2022. Isolation and feeder-free primary culture of four cell types from a single human skin sample. STAR protocols, 3 1, 101172Baumann, Molly E; DeBruler, Danielle M; Blackstone, Britani N; Coffey, Rebecca A; Boyce, Steven T; Supp, Dorothy M; Bailey, J Kevin; Powell, Heather M 2021. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties. Burns : journal of the International Society for Burn Injuries, 47 2, 466-478Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports, 11 1, 16555Gibson, A. L. F.; Carney, B. C.; Cuttle, L.; Andrews, C. J.; Kowalczewski, C. J.; Liu, A.; Powell, H. M.; Stone, R.; Supp, D. M.; Singer, A. J.; Shupp, J. W.; Stalter, L.; Moffatt, L. T. 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? J Burn Care Res, 42 1 , 98-109Gibson, Angela L F; Carney, Bonnie C; Cuttle, Leila; Andrews, Christine J; Kowalczewski, Christine J; Liu, Aiping; Powell, Heather M; Stone, Randolph; Supp, Dorothy M; Singer, Adam J; Shupp, Jeffrey W; Stalter, Lily; Moffatt, Lauren T 2021. Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? Journal of burn care & research : official publication of the American Burn Association, 42 1, 98-109Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Anness, M. C.; Supp, D. M. 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin Wound Repair Regen, 29 5 , 777-791Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Anness, Meridith C; Supp, Dorothy M 2021. Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 29 5, 777-791Powell, Heather M; Supp, Dorothy M; Bailey, J Kevin; Baumann, Molly E 2021. Response to the Letter to the Editor: Fractional CO2 laser ablation of porcine burn scars after grafting: Is deeper better? Burns : journal of the International Society for Burn Injuries, 47 2, 494-495Ruiz-Torres, S.; Brusadelli, M. G.; Witte, D. P.; Wikenheiser-Brokamp, K. A.; Sauter, S.; Nelson, A. S.; Sertorio, M.; Chlon, T. M.; Lane, A.; Mehta, P. A.; Myers, K. C.; Bedard, M. C.; Pal, B.; Supp, D. M.; Lambert, P. F.; Komurov, K.; Kovacic, M. B.; Davies, S. M.; Wells, S. I. 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin Cell Stem Cell, 28 3 , 424-435.e6Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Baumann, M. E.; DeBruler, D. M.; Blackstone, B. N.; Coffey, R. A.; Boyce, S. T.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2020. Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties Burns, 102 3-4 , 287-297Blackstone, B. N.; Malara, M. M.; Baumann, M. E.; McFarland, K. L.; Supp, D. M.; Powell, H. M. 2020. Fractional CO2 laser micropatterning of cell-seeded electrospun collagen scaffolds enables rete ridge formation in 3D engineered skin Acta Biomater, 102 3-4 , 287-297Boyce, S. T.; Supp, D. M.; Lloyd, C. M. 2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Isogeneic Cell Types Tissue Eng Part A, 26 3-4 , 214-224DeBruler, D. M.; Baumann, M. E.; Zbinden, J. C.; Blackstone, B. N.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy Adv Wound Care (New Rochelle), 9 8 , 453-61DeBruler, Danielle M; Baumann, Molly E; Zbinden, Jacob C; Blackstone, Britani N; Bailey, John Kevin; Supp, Dorothy M; Powell, Heather M 2020. Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy. Advances in wound care, 9 8, 453-461Malara, M. M.; Blackstone, B. N.; Baumann, M. E.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo Tissue Eng Part A, 26 21-22 , 1138-1146Malara, Megan M; Blackstone, Britani N; Baumann, Molly E; Bailey, J Kevin; Supp, Dorothy M; Powell, Heather M 2020. Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo. Tissue engineering. Part A, 26 21-22, 1138-1146Satish, L.; Evdokiou, A.; Geletu, E.; Hahn, J. M.; Supp, D. M. 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes Burns Trauma, 8 4 , tkz007Satish, Latha; Evdokiou, Alexander; Geletu, Eleni; Hahn, Jennifer M; Supp, Dorothy M 2020. Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes. Burns & trauma, 8 , tkz007Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Supp, D. M.; Hahn, J. M.; Lloyd, C. M.; Combs, K. A.; Swope, V. B.; Abdel-Malek, Z.; Boyce, S. T. 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo J Burn Care Res, 41 4 , 751-760Supp, Dorothy M; Hahn, Jennifer M; Lloyd, Christopher M; Combs, Kelly A; Swope, Viki B; Abdel-Malek, Zalfa; Boyce, Steven T 2020. Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo. Journal of burn care & research : official publication of the American Burn Association, 41 4, 751-760DeBruler, D. M.; Baumann, M. E.; Blackstone, B. N.; Zbinden, J. C.; McFarland, K. L.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plast Reconstr Surg, 143 2 , 310e-321eHahn, J. M.; Combs, K. A.; Lloyd, C. M.; McFarland, K. L.; Boyce, S. T.; Supp, D. M. 2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds PLoS One, 14 3 , e0213325Supp, D. M. 2019. Animal Models for Studies of Keloid Scarring Adv Wound Care (New Rochelle), 8 2 , 77-89Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Schwentker, A.; Boissy, R. E.; Boyce, S. T.; Powell, H. M.; Lucky, A. W. 2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes Burns, 28 9-10 , 1242-1256Supp, Dorothy M 2019. Animal Models for Studies of Keloid Scarring. Advances in wound care, 8 2, 77-89Bailey, J. K.; Blackstone, B. N.; DeBruler, D. M.; Kim, J. Y.; Baumann, M. E.; McFarland, K. L.; Imeokparia, F. O.; Supp, D. M.; Powell, H. M. 2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser Acta Biomater, 50 1 , 78-87Blackstone, B. N.; Hahn, J. M.; McFarland, K. L.; DeBruler, D. M.; Supp, D. M.; Powell, H. M. 2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro and post-grafting Acta Biomater, 80 17 , 247-257DeBruler, D. M.; Zbinden, J. C.; Baumann, M. E.; Blackstone, B. N.; Malara, M. M.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Early cessation of pressure garment therapy results in scar contraction and thickening J Burn Care Res, 13 6 , e0197558DeBruler, D. M.; Blackstone, B. N.; McFarland, K. L.; Baumann, M. E.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2018. Effect of skin graft thickness on scar development in a porcine burn model J Burn Care Res, 13 17 , 10Malara, M. M.; Kim, J. Y.; Clark, J. A.; Blackstone, B. N.; Ruegsegger, M. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use and Repeated Laundering J Burn Care Res, 39 4 , 562-571Blackstone, B. N.; Kim, J. Y.; McFarland, K. L.; Sen, C. K.; Supp, D. M.; Bailey, J. K.; Powell, H. M. 2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair Regen., 25 4 , 618-631Boyce, S. T.; Lloyd, C. M.; Kleiner, M. C.; Swope, V. B.; Abdel-Malek, Z.; Supp, D. M. 2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes Acta Biomater, 30 6 , 531-540DeBruler, D. M.; Blackstone, B. N.; Baumann, M. E.; McFarland, K. L.; Wulff, B. C.; Wilgus, T. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. 2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of scars Acta Biomater, 49 7 , 675-685Hahn, J. M.; Supp, D. M. 2017. Abnormal expression of the vitamin D receptor in keloid scars Acta Biomater, 43 7 , 1506-1515Sethuraman, S. A.; Gottschlich, M. M.; Supp, D. M.; Khoury, J.; Kagan, R. J. 2017. Vitamin D biomarkers associated with abnormal scar formation in pediatric burn patients Acta Biomater, 1 1 , 78-87Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Supp, D. M. 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-á1 Burns Trauma, 4 2 , 30Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Supp, Dorothy M 2016. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Burns & trauma, 4 1, 30Kim, J. Y.; Dunham, D. M.; Supp, D. M.; Sen, C. K.; Powell, H. M. 2016. Novel burn device for rapid, reproducible burn wound generation Plast Reconstr Surg Glob Open, 42 2 , 384-391Supp, D. M.; Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Lee, K. S.; Inceoglu, B.; Wan, D.; Boyce, S. T.; Hammock, B. D. 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes Plast Reconstr Surg Glob Open, 4 12 , e1151Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Lee, Kin Sing Stephen; Inceoglu, Bora; Wan, Debin; Boyce, Steven T; Hammock, Bruce D 2016. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plastic and reconstructive surgery. Global open, 4 12, e1151Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M 2015. Burn Scar Biomechanics Following Pressure Garment Therapy. Plastic and reconstructive surgery, , Alexander, J Wesley; Supp, Dorothy M 2014. Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection. Advances in wound care, 3 11, 682-690Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, , Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5Supp, Dorothy M 2012. Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes. Advances in wound care, 1 2, 63-68Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T 2012. LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, 12 , e19Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plastic and reconstructive surgery, 129 6, 1259-71Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4. Burns : journal of the International Society for Burn Injuries, 35 7, 949-55Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93Powell, Heather M; Supp, Dorothy M; Boyce, Steven T 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials, 29 7, 834-43Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman 2007. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1545-51Supp, Dorothy M 2007. Gene therapy to fight infection in skin transplants. Pharmacogenomics, 8 5, 483-6Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns : journal of the International Society for Burn Injuries, 32 2, 135-8Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. The Journal of investigative dermatology, 125 6, 1286-301Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns : journal of the International Society for Burn Injuries, 30 7, 643-8Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 8, 797-804Supp, D M; Supp, A P; Bell, S M; Boyce, S T 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. The Journal of investigative dermatology, 114 1, 5-13Boyce S.;Lloyd C.;Kleiner M.;Swope V.;Abdel-Malek Z.;Supp D. 11-01-2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in d Pigment Cell and Melanoma Research, 30 6, 531-540Hahn J.;Supp D. 11-01-2017. Abnormal expression of the vitamin D receptor in keloid scars Burns, 43 7, 1506-1515Forouzandeh F.;Jalili R.;Hartwell R.;Allan S.;Boyce S.;Supp D.;Ghahary A. 11-01-2010. Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineere Wound Repair and Regeneration, 18 6, 614-623Blackstone B.;Hahn J.;McFarland K.;DeBruler D.;Supp D.;Powell H. 10-15-2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro Acta Biomaterialia, 80 , 247-257Supp D.M.;Hahn J.M.;Combs K.A.;McFarland K.L.;Schwentker A.;Boissy R.E.;Boyce S.T.;Powell H.M.;Lucky A.W. 09-01-2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Forma Cell Transplantation, 28 9-10, 1242-1256DeBruler D.;Blackstone B.;Baumann M.;McFarland K.;Wulff B.;Wilgus T.;Bailey J.;Supp D.;Powell H. 09-01-2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO<inf>2& Lasers in Surgery and Medicine, 49 7, 675-685Lander J.;Supp D.;He H.;Martin L.;Chen X.;Weirauch M.;Boyce S.;Kopan R. 09-01-2017. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensi PLoS ONE, 12 9, Blackstone B.;Kim J.;McFarland K.;Sen C.;Supp D.;Bailey J.;Powell H. 07-01-2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair and Regeneration, 25 4, 618-631Malara M.;Kim J.;Clark J.;Blackstone B.;Ruegsegger M.;Bailey J.;Supp D.;Powell H. 06-13-2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use Journal of Burn Care and Research, 39 4, 562-571DeBruler D.;Blackstone B.;McFarland K.;Baumann M.;Supp D.;Bailey J.;Powell H. 06-01-2018. Effect of skin graft thickness on scar development in a porcine burn model Burns, 44 4, 917-930DeBruler D.;Zbinden J.;Baumann M.;Blackstone B.;Malara M.;Bailey J.;Supp D.;Powell H. 06-01-2018. Early cessation of pressure garment therapy results in scar contraction and thickening PLoS ONE, 13 6, Kalyanaraman B.;Supp D.;Boyce S. 05-01-2008. 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Bioengineering of human skin substitutes Tissue Engineering, , 275-291Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M . Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M . Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M . 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