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Nicolas Nassar

Research Associate Professor-Affiliate

Pediatrics | College of Medicine

Contact Information

Peer Reviewed Publications

Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N 2020. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PloS one, 15 3, e0229801

Seu, Katie G; Trump, Lisa R; Emberesh, Sana; Lorsbach, Robert B; Johnson, Clarissa; Meznarich, Jessica; Underhill, Hunter R; Chou, Stella T; Sakthivel, Haripriya; Nassar, Nicolas N; Seu, Kalani J; Blanc, Lionel; Zhang, Wenying; Lutzko, Carolyn M; Kalfa, Theodosia A 2020. VPS4A Mutations in Humans Cause Syndromic Congenital Dyserythropoietic Anemia due to Cytokinesis and Trafficking Defects. American journal of human genetics, 107 6, 1149-1156

Liu, Wei; Du, Wei; Shang, Xun; Wang, Lei; Evelyn, Chris; Florian, Maria Carolina; A Ryan, Marnie; Rayes, Ahmad; Zhao, Xueheng; Setchell, Kenneth; Meller, Jarek; Guo, Fukun; Nassar, Nicolas; Geiger, Hartmut; Pang, Qishen; Zheng, Yi 2019. Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization. Leukemia, 33 3, 749-761

Lee, Lynn H; Gasilina, Anjelika; Roychoudhury, Jayeeta; Clark, Jason; McCormack, Francis X; Pressey, Joseph; Grimley, Michael S; Lorsbach, Robert; Ali, Siraj; Bailey, Mark; Stephens, Philip; Ross, Jeffrey S; Miller, Vincent A; Nassar, Nicolas N; Kumar, Ashish R 2017. Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes. JCI insight, 2 3, e89473

Privette Vinnedge, Lisa M; Kappes, Ferdinand; Nassar, Nicolas; Wells, Susanne I 2013. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex.), 12 1, 51-66

San Luis, Boris; Nassar, Nicolas; Carpino, Nick 2013. New insights into the catalytic mechanism of histidine phosphatases revealed by a functionally essential arginine residue within the active site of the Sts phosphatases. The Biochemical journal, 453 1, 27-35

San Luis, Boris; Sondgeroth, Ben; Nassar, Nicolas; Carpino, Nick 2011. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. The Journal of biological chemistry, 286 18, 15943-54

Jakoncic, Jean; Sondgeroth, Benjamin; Carpino, Nick; Nassar, Nicolas 2010. The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate. Acta crystallographica. Section F, Structural biology and crystallization communications, 66 Pt 6, 643-7

Nassar, Nicolas; Singh, Kavita; Garcia-Diaz, Miguel 2010. Structure of the dominant negative S17N mutant of Ras. Biochemistry, 49 9, 1970-4

Carpino, Nick; Chen, Yunting; Nassar, Nicolas; Oh, Hye-Won 2009. The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways. Molecular immunology, 46 16, 3224-31

Chen, Yunting; Jakoncic, Jean; Carpino, Nick; Nassar, Nicolas 2009. Structural and functional characterization of the 2H-phosphatase domain of Sts-2 reveals an acid-dependent phosphatase activity. Biochemistry, 48 8, 1681-90

Chen, Yunting; Jakoncic, Jean; Parker, Kathlyn A; Carpino, Nick; Nassar, Nicolas 2009. Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2. Biochemistry, 48 34, 8129-35

Ford, Bradley; Boykevisch, Sean; Zhao, Chen; Kunzelmann, Simone; Bar-Sagi, Dafna; Herrmann, Christian; Nassar, Nicolas 2009. Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry, 48 48, 11449-57

Chen, Yunting; Jakoncic, Jean; Wang, Jin; Zheng, Xiliang; Carpino, Nick; Nassar, Nicolas 2008. Structural and functional characterization of the c-terminal domain of the ecdysteroid phosphate phosphatase from bombyx mori reveals a new enzymatic activity. Biochemistry, 47 46, 12135-45

Mikhailik, Anatoly; Ford, Bradley; Keller, James; Chen, Yunting; Nassar, Nicolas; Carpino, Nick 2007. A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Molecular cell, 27 3, 486-97

Ford, Bradley; Hornak, Viktor; Kleinman, Holly; Nassar, Nicolas 2006. Structure of a transient intermediate for GTP hydrolysis by ras. Structure (London, England : 1993), 14 3, 427-36

Kleinman, Holly; Ford, Bradley; Keller, James; Carpino, Nick; Nassar, Nicolas 2006. Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1. Acta crystallographica. Section F, Structural biology and crystallization communications, 62 Pt 3, 218-20

Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi 2006. Structure-function based design of small molecule inhibitors targeting Rho family GTPases. Current topics in medicinal chemistry, 6 11, 1109-16

Xiang, Song; Kim, Eun Young; Connelly, Jessica J; Nassar, Nicolas; Kirsch, Joachim; Winking, Jan; Schwarz, Günter; Schindelin, Hermann 2006. The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor. Journal of molecular biology, 359 1, 35-46

Ford, Bradley; Skowronek, Karlheinz; Boykevisch, Sean; Bar-Sagi, Dafna; Nassar, Nicolas 2005. Structure of the G60A mutant of Ras: implications for the dominant negative effect. The Journal of biological chemistry, 280 27, 25697-705

Skowronek, Karlheinz R; Guo, Fukun; Zheng, Yi; Nassar, Nicolas 2004. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids. The Journal of biological chemistry, 279 36, 37895-907

Skowronek, Karlheinz; Ghumman, Mohammed; Zheng, Yi; Nassar, Nicolas 2003. Crystallization and initial crystal characterization of the N-terminal DH/PH domain of Trio. Acta crystallographica. Section D, Biological crystallography, 59 Pt 7, 1273-5

Smith, William James; Nassar, Nicolas; Bretscher, Anthony; Cerione, Richard A; Karplus, P Andrew 2003. Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. The Journal of biological chemistry, 278 7, 4949-56

Hall, Brian E; Bar-Sagi, Dafna; Nassar, Nicolas 2002. The structural basis for the transition from Ras-GTP to Ras-GDP. Proceedings of the National Academy of Sciences of the United States of America, 99 19, 12138-42