- Master's Degree: University of Cincinnati College of Medicine (Clinical Research/Molecular Epidemiology)
- Fellowship : University of Cincinnati College of Medicine (Allergy & Immunology )
- Resident : Barnes-Jewish Hospital/Washington University (Internal Medicine )
- Medical Degree: Indiana University School of Medicine
- Bachelor's Degree: Indiana University (Biology & Spanish (English Minor))
American Board of Allergy and Immunology (Certification Date: 2010-10-08)
American Board of Internal Medicine (Certification Date: 2006-09-01)
- Medical Sciences Building
- Email epsteite@ucmail.uc.edu
Research interests: Allergen immunotherapy, Asthma in Older Adults, Impact of Air pollutants on Asthma and Allergic Diseases
Practice interests: A wide range of allergic disorders including asthma, rhinitis, food allergy, hives/angioedema, and contact dermatitis, as well as immunologic disorders including immune deficiencies
Epstein, Tolly G; Berendts, Karen; Bernstein, David I 2026. Impact of Dose Adjustment After Gaps in Subcutaneous Immunotherapy: Update From the North American Immunotherapy Surveillance Study (2008-2023). The journal of allergy and clinical immunology. In practice, 14 1, 253-259.e2
Epstein, Tolly; Bernstein, David I 2026. Immunotherapy in Allergic and Mixed Rhinitis. Immunology and allergy clinics of North America, 46 1, 111-124
Epstein, Tolly E G; Rorie, Andrew C; Ramon, German D; Keswani, Anjeni; Bernstein, Jonathan; Codina, Rosa; Codispoti, Christopher; Craig, Timothy; Dykewicz, Mark; Ferastraoaru, Denisa; Katz, Daniel; Kim, Jean; Larenas-Linnemann, Désirée; Nanda, Anil; Nguyen, Anh; Anand, Mahesh Padukudru; Patterson, Amber; Ponda, Punita; Toskala, Elina; Wasan, Anita N 2025. Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology. The Journal of allergy and clinical immunology, 155 6, 1767-1782.e2
Bernstein, David I; Khan, Najeeb; Epstein, Tolly G 2023. Reply to "Does hydroxychloroquine work for chronic spontaneous urticaria?". The journal of allergy and clinical immunology. In practice, 11 6, 1983-1984
Larenas-Linnemann, Désirée; Ponda, Punita; Creticos, Peter; Bernstein, David; Epstein, Tolly; Williams, Paul 2023. Dose Adjustment After Gaps in Administration of Subcutaneous Immunotherapy From a Past Survey: Work Group Report of the AAAAI Allergen Standardization and Allergy Diagnostics Committee. The journal of allergy and clinical immunology. In practice, 11 1, 145-148.e4
Bernstein, David I; Epstein, Tolly G 2022. Managing risk of anaphylaxis in patients receiving allergen immunotherapy: Assessing benefit versus risk. The Journal of allergy and clinical immunology, 149 3, 884-886
Chow, Timothy G; Palka, Jayme M; Stone, Brian; Trojan, Timothy; Epstein, Tolly G; Khan, David A 2022. Safety of subcutaneous immunotherapy in patients with severe asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 129 5, 585-591.e3
Dhamija, Yashu; Epstein, Tolly E G; Bernstein, David I 2022. Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy. Immunology and allergy clinics of North America, 42 1, 105-119
Epstein, Tolly E G; Calabria, Christopher W 2022. Is immunotherapy safe for treatment of severe asthma. Current opinion in allergy and clinical immunology, 22 6, 396-401
Khan, Najeeb; Epstein, Tolly G; DuBuske, Ilona; Strobel, Maria; Bernstein, David I 2022. Effectiveness of Hydroxychloroquine and Omalizumab in Chronic Spontaneous Urticaria: A Real-World Study. The journal of allergy and clinical immunology. In practice, 10 12, 3300-3305
Epstein, Tolly G; Murphy-Berendts, Karen; Liss, Gary M; Bernstein, David I 2021. Risk factors for fatal and nonfatal reactions to immunotherapy (2008-2018): postinjection monitoring and severe asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 127 1, 64-69.e1
Larenas-Linnemann, Désirée Erlinda; Epstein, Tolly; Ponda, Punita; Bernstein, David; Williams, Paul; Creticos, Peter 2020. Gaps in allergen immunotherapy administration and subcutaneous allergen immunotherapy dose adjustment schedules: Need for prospective data. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 125 5, 505-506.e2
Epstein, Tolly G; Liss, Gary M; Berendts, Karen Murphy; Bernstein, David I 2019. AAAAI/ACAAI Subcutaneous Immunotherapy Surveillance Study (2013-2017): Fatalities, Infections, Delayed Reactions, and Use of Epinephrine Autoinjectors. The journal of allergy and clinical immunology. In practice, 7 6, 1996-2003.e1
Epstein, Tolly E; Tankersley, Mike S 2017. Are Allergen Immunotherapy Dose Adjustments Needed for Local Reactions, Peaks of Season, or Gaps in Treatment? The journal of allergy and clinical immunology. In practice, 5 5, 1227-1233
Epstein, Tolly G; Calabria, Christopher; Cox, Linda S; Dreborg, Sten 2017. Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States. The journal of allergy and clinical immunology. In practice, 5 1, 34-40.e2
Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I 2017. Evaluation of the risk of infection associated with subcutaneous allergen immunotherapy: American Academy of Allergy, Asthma, and Immunology and American College of Allergy, Asthma, and Immunology National Surveillance Study on Allergen Immunotherapy, 2014-2015. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 118 4, 511-512
Davis, Benjamin P; Epstein, Tolly; Kottyan, Leah; Amin, Priyal; Martin, Lisa J; Maddox, Avery; Collins, Margaret H; Sherrill, Joseph D; Abonia, J Pablo; Rothenberg, Marc E 2016. Association of eosinophilic esophagitis and hypertrophic cardiomyopathy. The Journal of allergy and clinical immunology, 137 3, 934-6.e5
Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I 2016. Risk factors for fatal and nonfatal reactions to subcutaneous immunotherapy: National surveillance study on allergen immunotherapy (2008-2013). Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 116 4, 354-359.e2
Kannan, Jennifer A; Bernstein, David I; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Epstein, Tolly G 2015. Significant predictors of poor quality of life in older asthmatics. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 115 3, 198-204
Amin, Priyal; Levin, Linda; Epstein, Tolly; Ryan, Pat; LeMasters, Grace; Khurana Hershey, Gurjit; Reponen, Tina; Villareal, Manuel; Lockey, James; Bernstein, David I 2014. Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index? The journal of allergy and clinical immunology. In practice, 2 6, 709-15
Cheng, G; Smith, A M; Levin, L; Epstein, T; Ryan, P H; LeMasters, G K; Khurana Hershey, G K; Reponen, T; Villareal, M; Lockey, J; Bernstein, D I 2014. Duration of day care attendance during infancy predicts asthma at the age of seven: the Cincinnati Childhood Allergy and Air Pollution Study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44 10, 1274-81
Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I 2014. AAAAI/ACAAI surveillance study of subcutaneous immunotherapy, years 2008-2012: an update on fatal and nonfatal systemic allergic reactions. The journal of allergy and clinical immunology. In practice, 2 2, 161-7
Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I 2013. Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics. The Journal of asthma : official journal of the Association for the Care of Asthma, 50 9, 983-9
Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I 2013. AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions? Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110 4, 274-8, 278.e1
Kannan, Jennifer A; Epstein, Tolly G 2013. Immunotherapy safety: what have we learned from surveillance surveys? Current allergy and asthma reports, 13 4, 381-8
Epstein, Tolly G; LeMasters, Grace K; Bernstein, David I; Ericksen, Mark B; Martin, Lisa J; Ryan, Patrick H; Biagini Myers, Jocelyn M; Butsch Kovacic, Melinda S; Lindsey, Mark A; He, Hua; Reponen, Tiina; Villareal, Manuel S; Lockey, James E; Bernstein, Cheryl K; Khurana Hershey, Gurjit K 2012. Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 108 3, 145-50
Epstein, Tolly G; Ryan, Patrick H; LeMasters, Grace K; Bernstein, Cheryl K; Levin, Linda S; Bernstein, Jonathan A; Villareal, Manuel S; Bernstein, David I 2012. Poor asthma control and exposure to traffic pollutants and obesity in older adults. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 108 6, 423-428.e2
Bernstein, David I; Epstein, Tolly 2011. Systemic reactions to subcutaneous allergen immunotherapy. Immunology and allergy clinics of North America, 31 2, 241-9, viii-ix
Epstein, Tolly G; Bernstein, David I; Levin, Linda; Khurana Hershey, Gurjit K; Ryan, Patrick H; Reponen, Tiina; Villareal, Manuel; Lockey, James E; Lemasters, Grace K 2011. Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort. The Journal of pediatrics, 158 2, 265-71.e1-5
Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I 2011. Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 107 5, 426-431.e1
Bernstein, David I; Epstein, Tolly; Murphy-Berendts, Karen; Liss, Gary M 2010. Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 104 6, 530-5
Biagini Myers, Jocelyn M; Wang, Ning; LeMasters, Grace K; Bernstein, David I; Epstein, Tolly G; Lindsey, Mark A; Ericksen, Mark B; Chakraborty, Ranajit; Ryan, Patrick H; Villareal, Manuel S; Burkle, Jeff W; Lockey, James E; Reponen, Tiina; Khurana Hershey, Gurjit K 2010. Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort. The Journal of investigative dermatology, 130 2, 430-7
Epstein, Tolly G; Bernstein, Jonathan A 2008. Current and emerging management options for hereditary angioedema in the US. Drugs, 68 18, 2561-73