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Photo of  Andrew P. Duker, MD

Andrew P. Duker, MD

Professor of Clinical

Division Director, Clinical Endowed Chair; James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders

Neurology & Rehabilitation Medicine | College of Medicine

Education/Credentials
  • Fellowship: University of Cincinnati (Movement Disorders)
  • Residency: University of Cincinnati (Neurology)
  • Internship: The Christ Hospital (Internal Medicine )
  • Bachelor's Degree: The College of Wooster (Psychology)
  • Medical Degree: University of Toledo
Board Certifications & Licenses

American Board of Psychiatry and Neurology (Neurology) (Certification Date: 2008-05-11) - (Recertification Date: 2018-10-29)

Specialties

Neurology

Contact Information
Research Interests

Movement Disorders, Parkinson's Disease

Clinical Interests

Movement Disorders

Neurology

Parkinson's Disease

Alzheimer's Disease

Ataxia

Balance Disorders

Bell's Palsy

Cataplexy

Catatonia

Cerebellar Ataxia

Chorea

Corticobasal Degeneration (CBD)

Dementia

Dyskinesias

Dystonia

Essential Tremor (ET)

Gait Disorders

Hemifacial Spasm

Hereditary Spastic Paraplegia

Huntington's Disease

Hyperkalemic Periodic Paralysis

Hypokalemic Periodic Paralysis

Lewy Body Dementia

Lewy Body Disease

Multiple System Atrophy (MSA)

Muscle Rigidity

Muscle Spasticity

Myoclonic Seizures

Normal Pressure Hydrocephalus

Orthostatic Hypotension (Postural Hypotension)

Paraparesis

Parkinson's Hypophonia (Bowing/Atrophy)

Posterior Cortical Atrophy

Prion Disease

Psychomotor Disorders

Sensory Ataxia

Serotonin Syndrome

Spasms

Spinocerebellar Ataxia (SCA)

Spinocerebellar Degenerations

Stiff-Person Syndrome

Subacute Combined Degeneration

Tauopathies

Tay-Sachs Disease

TDP-43 Proteinopathies

Tics and Tourette Syndrome

Tourette Syndrome

Tremors

Tropical Spastic Paraparesis

Vascular Cognitive Impairment

Vascular Dementia

Wernicke Encephalopathy

Peer Reviewed Publications

Brownstein, Michael J; Simon, Neal G; Long, Jeffrey D; Yankey, Jon; Maibach, Hilda T; Cudkowicz, Merit; Coffey, Christopher; Conwit, Robin A; Lungu, Codrin; Anderson, Karen E; Hersch, Steven M; Ecklund, Dixie J; Damiano, Eve M; Itzkowitz, Debra E; Lu, Shifang; Chase, Marianne K; Shefner, Jeremy M; McGarry, Andrew; Thornell, Brenda; Gladden, Catherine; Costigan, Michele; O'Suilleabhain, Padraig; Marshall, Frederick J; Chesire, Amy M; Deritis, Paul; Adams, Jamie L; Hedera, Peter; Lowen, Kelly; Rosas, H Diana; Hiller, Amie L; Quinn, Joseph; Keith, Kellie; Duker, Andrew P; Gruenwald, Christina; Molloy, Angela; Jacob, Cara; Factor, Stewart; Sperin, Elaine; Bega, Danny; Brown, Zsazsa R; Seeberger, Lauren C; Sung, Victor W; Benge, Melanie; Kostyk, Sandra K; Daley, Allison M; Perlman, Susan; Suski, Valerie; Conlon, Patricia; Barrett, Matthew J; Lowenhaupt, Stephanie; Quigg, Mark; Perlmutter, Joel S; Wright, Brenton A; Most, Elaine; Schwartz, Guy J; Lamb, Jessica; Chuang, Rosalind S; Singer, Carlos; Marder, Karen; Moran, Joyce A; Singleton, John R; Zorn, Meghan; Wall, Paola V; Dubinsky, Richard M; Gray, Carolyn; Drazinic, Carolyn 2020. Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial. Journal of clinical medicine, 9 11,

Mahajan, Abhimanyu; Bader, Alexander; Wang, Lily L; Rekhtman, Aleksander; Espay, Alberto J; Dwivedi, Alok K; Sturchio, Andrea; Marsili, Luca; Duker, Andrew P; Krishna, Vibhor; Mandybur, George T; Merola, Aristide 2020. Thalamic Deep Brain Stimulation for tremor: The critical role of intraoperative testing. Parkinsonism & related disorders, 73 , 45-49

Merola, Aristide; Romagnolo, Alberto; Krishna, Vibhor; Pallavaram, Srivatsan; Carcieri, Stephen; Goetz, Steven; Mandybur, George; Duker, Andrew P; Dalm, Brian; Rolston, John D; Fasano, Alfonso; Verhagen, Leo 2020. Current Directions in Deep Brain Stimulation for Parkinson's Disease-Directing Current to Maximize Clinical Benefit. Neurology and therapy, 9 1, 25-41

Sturchio, Andrea; Marsili, Luca; Vizcarra, Joaquin A; Dwivedi, Alok K; Kauffman, Marcelo A; Duker, Andrew P; Lu, Peixin; Pauciulo, Michael W; Wissel, Benjamin D; Hill, Emily J; Stecher, Benjamin; Keeling, Elizabeth G; Vagal, Achala S; Wang, Lily; Haslam, David B; Robson, Matthew J; Tanner, Caroline M; Hagey, Daniel W; El Andaloussi, Samir; Ezzat, Kariem; Fleming, Ronan M T; Lu, Long J; Little, Max A; Espay, Alberto J 2020. Phenotype-Agnostic Molecular Subtyping of Neurodegenerative Disorders: The Cincinnati Cohort Biomarker Program (CCBP). Frontiers in aging neuroscience, 12 , 553635

Vitek, Jerrold L; Jain, Roshini; Chen, Lilly; Tröster, Alexander I; Schrock, Lauren E; House, Paul A; Giroux, Monique L; Hebb, Adam O; Farris, Sierra M; Whiting, Donald M; Leichliter, Timothy A; Ostrem, Jill L; San Luciano, Marta; Galifianakis, Nicholas; Verhagen Metman, Leo; Sani, Sepehr; Karl, Jessica A; Siddiqui, Mustafa S; Tatter, Stephen B; Ul Haq, Ihtsham; Machado, Andre G; Gostkowski, Michal; Tagliati, Michele; Mamelak, Adam N; Okun, Michael S; Foote, Kelly D; Moguel-Cobos, Guillermo; Ponce, Francisco A; Pahwa, Rajesh; Nazzaro, Jules M; Buetefisch, Cathrin M; Gross, Robert E; Luca, Corneliu C; Jagid, Jonathan R; Revuelta, Gonzalo J; Takacs, Istvan; Pourfar, Michael H; Mogilner, Alon Y; Duker, Andrew P; Mandybur, George T; Rosenow, Joshua M; Cooper, Scott E; Park, Michael C; Khandhar, Suketu M; Sedrak, Mark; Phibbs, Fenna T; Pilitsis, Julie G; Uitti, Ryan J; Starr, Philip A 2020. Subthalamic nucleus deep brain stimulation with a multiple independent constant current-controlled device in Parkinson's disease (INTREPID): a multicentre, double-blind, randomised, sham-controlled study. The Lancet. Neurology, 19 6, 491-501

Krikorian, Robert; Shidler, Marcelle D; Summer, Suzanne S; Sullivan, Patrick G; Duker, Andrew P; Isaacson, Richard S; Espay, Alberto J 2019. Nutritional ketosis for mild cognitive impairment in Parkinson's disease: A controlled pilot trial. Clinical parkinsonism & related disorders, 1 , 41-47

Vizcarra, Joaquin A; Situ-Kcomt, Miguel; Artusi, Carlo Alberto; Duker, Andrew P; Lopiano, Leonardo; Okun, Michael S; Espay, Alberto J; Merola, Aristide 2019. Subthalamic deep brain stimulation and levodopa in Parkinson's disease: a meta-analysis of combined effects. Journal of neurology, 266 2, 289-297

Zaidi, Syed Amir; Saal, Howard M; Espay, Alberto J; Duker, Andrew P 2019. The "broken wishbone" splenial sign: A diagnostic hallmark for SPG54 spastic ataxia. Journal of the neurological sciences, 403 , 114-116

Artusi, Carlo Alberto; Farooqi, Ashar; Romagnolo, Alberto; Marsili, Luca; Balestrino, Roberta; Sokol, Leonard L; Wang, Lily L; Zibetti, Maurizio; Duker, Andrew P; Mandybur, George T; Lopiano, Leonardo; Merola, Aristide 2018. Deep brain stimulation in uncommon tremor disorders: indications, targets, and programming. Journal of neurology, 265 11, 2473-2493

Tareen, Tamour Khan; Artusi, Carlo Alberto; Rodriguez-Porcel, Federico; Devoto, Johnna L; Sheikh, Habibullah; Mandybur, George T; Duker, Andrew P; Espay, Alberto J; Merola, Aristide 2018. Dopaminergic dose adjustment and negative affective symptoms after deep brain stimulation. Journal of the neurological sciences, 390 , 33-35

Wissel, Benjamin D; Dwivedi, Alok K; Merola, Aristide; Chin, Danielle; Jacob, Cara; Duker, Andrew P; Vaughan, Jennifer E; Lovera, Lilia; LaFaver, Kathrin; Levy, Ariel; Lang, Anthony E; Morgante, Francesca; Nirenberg, Melissa Jill; Stephen, Christopher; Sharma, Nutan; Romagnolo, Alberto; Lopiano, Leonardo; Balint, Bettina; Yu, Xin X; Bhatia, Kailash P; Espay, Alberto J 2018. Functional neurological disorders in Parkinson disease. Journal of neurology, neurosurgery, and psychiatry, 89 6, 566-571

Espay, Alberto J; Da Prat, Gustavo A; Dwivedi, Alok K; Rodriguez-Porcel, Federico; Vaughan, Jennifer E; Rosso, Michela; Devoto, Johnna L; Duker, Andrew P; Masellis, Mario; Smith, Charles D; Mandybur, George T; Merola, Aristide; Lang, Anthony E 2017. Deconstructing normal pressure hydrocephalus: Ventriculomegaly as early sign of neurodegeneration. Annals of neurology, 82 4, 503-513

Merola, A; Mandybur, G; Biddell, K; Tareen, T K; Wilson-Perez, H; Espay, A J; Duker, A P 2017. Subthalamic or red nucleus? A puzzling question arising during intraoperative recording for DBS. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 128 4, 558-560

Merola, Aristide; Duker, Andrew P; Mandybur, George; Tareen, Tamour Khan; Tuazon, Jasmine; Espay, Alberto J; Fasano, Alfonso 2017. Thalamic deep brain stimulation and gait in orthostatic tremor. Movement disorders : official journal of the Movement Disorder Society, 32 6, 937-938

Merola, Aristide; Fasano, Alfonso; Hassan, Anhar; Ostrem, Jill L; Contarino, Maria Fiorella; Lyons, Mark; Krauss, Joachim K; Wolf, Marc E; Klassen, Bryan T; van Rootselaar, Anne-Fleur; Regidor, Ignacio; Duker, Andrew P; Ondo, William; Guridi, Jorge; Volkmann, Jens; Wagle Shukla, Aparna; Mandybur, George T; Okun, Michael S; Witt, Karsten; Starr, Philip A; Deuschl, Günther; Espay, Alberto J 2017. Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry. Movement disorders : official journal of the Movement Disorder Society, 32 8, 1240-1244

Merola, Aristide; Romagnolo, Alberto; Comi, Cristoforo; Rosso, Michela; Artusi, Carlo Alberto; Zibetti, Maurizio; Lanotte, Michele; Duker, Andrew P; Maule, Simona; Lopiano, Leonardo; Espay, Alberto J 2017. Prevalence and burden of dysautonomia in advanced Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 32 5, 796-797

Merola, Aristide; Romagnolo, Alberto; Rizzi, Laura; Rizzone, Mario Giorgio; Zibetti, Maurizio; Lanotte, Michele; Mandybur, George; Duker, Andrew P; Espay, Alberto J; Lopiano, Leonardo 2017. Impulse control behaviors and subthalamic deep brain stimulation in Parkinson disease. Journal of neurology, 264 1, 40-48

Tetrud, James; Nausieda, Paul; Kreitzman, David; Liang, Grace S; Nieves, Anette; Duker, Andrew P; Hauser, Robert A; Farbman, Eric S; Ellenbogen, Aaron; Hsu, Ann; Kell, Sherron; Khanna, Sarita; Rubens, Robert; Gupta, Suneel 2017. Conversion to carbidopa and levodopa extended-release (IPX066) followed by its extended use in patients previously taking controlled-release carbidopa-levodopa for advanced Parkinson's disease. Journal of the neurological sciences, 373 , 116-123

Rodriguez-Porcel, Federico; Jamali, Sheheryar; Duker, Andrew P; Espay, Alberto J 2016. Dopamine transporter scanning in the evaluation of patients with suspected Parkinsonism: a case-based user's guide. Expert review of neurotherapeutics, 16 1, 23-9

Laub, Holly N; Dwivedi, Alok K; Revilla, Fredy J; Duker, Andrew P; Pecina-Jacob, Cara; Espay, Alberto J 2015. Diagnostic performance of the "Huffing and Puffing" sign in psychogenic (functional) movement disorders. Movement disorders clinical practice, 2 1, 29-32

Hadjivassiliou, Marios; Duker, Andrew P; Sanders, David S 2014. Gluten-related neurologic dysfunction. Handbook of clinical neurology, 120 , 607-19

Duker, Andrew P 2013. Video recording in movement disorders: practical issues. Continuum (Minneapolis, Minn.), 19 5 Movement Disorders, 1401-5

Duker, Andrew P; Espay, Alberto J 2013. Surgical treatment of Parkinson disease: past, present, and future. Neurologic clinics, 31 3, 799-808

Mehta, Shyamal H; Nichols, Fenwick T; Espay, Alberto J; Duker, Andrew P; Morgan, John C; Sethi, Kapil D 2013. Dilated Virchow-Robin spaces and parkinsonism. Movement disorders : official journal of the Movement Disorder Society, 28 5, 589-90

Revilla, Fredy J; Larsh, Travis R; Mani, Ashutosh; Duker, Andrew P; Cox, Cyndy; Succop, Paul; Gartner, Maureen; Jarrin Tejada, Claudia; Bhattacharya, Amit 2013. Effect of dopaminergic medication on postural sway in advanced Parkinson's disease. Frontiers in neurology, 4 , 202

Duker, Andrew P; Espay, Alberto J; Wszolek, Zbigniew K; Rademakers, Rosa; Dickson, Dennis W; Kelley, Brendan J 2012. Atypical motor and behavioral presentations of Alzheimer disease: a case-based approach. The neurologist, 18 5, 266-72

Fasano, Alfonso; Valadas, Anabela; Bhatia, Kailash P; Prashanth, L K; Lang, Anthony E; Munhoz, Renato P; Morgante, Francesca; Tarsy, Daniel; Duker, Andrew P; Girlanda, Paolo; Bentivoglio, Anna Rita; Espay, Alberto J 2012. Psychogenic facial movement disorders: clinical features and associated conditions. Movement disorders : official journal of the Movement Disorder Society, 27 12, 1544-51

Kelley, Brendan J; Duker, Andrew P; Chiu, Peter 2012. Dopamine agonists and pathologic behaviors. Parkinson's disease, 2012 , 603631

Espay, A J; Dwivedi, A K; Payne, M; Gaines, L; Vaughan, J E; Maddux, B N; Slevin, J T; Gartner, M; Sahay, A; Revilla, F J; Duker, A P; Shukla, R 2011. Methylphenidate for gait impairment in Parkinson disease: a randomized clinical trial. Neurology, 76 14, 1256-62

Espay, Alberto J; Giuffrida, Joe P; Chen, Robert; Payne, Megan; Mazzella, Filomena; Dunn, Emily; Vaughan, Jennifer E; Duker, Andrew P; Sahay, Alok; Kim, Sang Jin; Revilla, Fredy J; Heldman, Dustin A 2011. Differential response of speed, amplitude, and rhythm to dopaminergic medications in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 26 14, 2504-8

Espay, Alberto J; Vaughan, Jennifer E; Shukla, Rakesh; Gartner, Maureen; Sahay, Alok; Revilla, Fredy J; Duker, Andrew P 2011. Botulinum toxin type A for Levodopa-induced cervical dyskinesias in Parkinson's disease: unfavorable risk-benefit ratio. Movement disorders : official journal of the Movement Disorder Society, 26 5, 913-4

Heldman, Dustin A; Giuffrida, Joseph P; Chen, Robert; Payne, Megan; Mazzella, Filomena; Duker, Andrew P; Sahay, Alok; Kim, Sang Jin; Revilla, Fredy J; Espay, Alberto J 2011. The modified bradykinesia rating scale for Parkinson's disease: reliability and comparison with kinematic measures. Movement disorders : official journal of the Movement Disorder Society, 26 10, 1859-63

Duker, Andrew P; Espay, Alberto J 2010. Images in clinical medicine. Hemichorea–hemiballism after diabetic ketoacidosis. The New England journal of medicine, 363 17, e27

Espay, Alberto J; Baram, Yoram; Dwivedi, Alok Kumar; Shukla, Rakesh; Gartner, Maureen; Gaines, Laura; Duker, Andrew P; Revilla, Fredy J 2010. At-home training with closed-loop augmented-reality cueing device for improving gait in patients with Parkinson disease. Journal of rehabilitation research and development, 47 6, 573-81

Espay, Alberto J; Duker, Andrew P; Chen, Robert; Okun, Michael S; Barrett, Edwin T; Devoto, Johnna; Zeilman, Pamela; Gartner, Maureen; Burton, Noël; Miranda, Helard A; Mandybur, George T; Zesiewicz, Theresa A; Foote, Kelly D; Revilla, Fredy J 2008. Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations. Movement disorders : official journal of the Movement Disorder Society, 23 16, 2357-62

Espay, Alberto J; Narayan, Raj K; Duker, Andrew P; Barrett, Edwin T; de Courten-Myers, Gabrielle 2008. Lower-body parkinsonism: reconsidering the threshold for external lumbar drainage. Nature clinical practice. Neurology, 4 1, 50-5

Espay,A. J., Duker,A. P., Chen,R., Okun,M. S., Barrett,E. T., Devoto,J., Zeilman,P., Gartner,M., Burton,N., Miranda,H. A., Mandybur,G. T., Zesiewicz,T. A., Foote,K. D., Revilla,F. J. 2008. Deep brain stimulation of the ventral intermediate nucleus of the thalamus in medically refractory orthostatic tremor: preliminary observations Movement disorders : official journal of the Movement Disorder Society, 23 16, 2357

Espay,A. J., Narayan,R. K., Duker,A. P., Barrett,E. T.,Jr, de Courten-Myers,G. 2008. Lower-body parkinsonism: reconsidering the threshold for external lumbar drainage Nature clinical practice.Neurology, 4 1, 50

Duker, Andrew P; Espay, Alberto J 2007. Parkinsonism associated with striatal perivascular space dilation. Neurology, 68 18, 1540

Duker,A. P., Espay,A. J. 2007. Parkinsonism associated with striatal perivascular space dilation Neurology, 68 18, 1540

Jacob, Cara; Espay, Alberto J; Hagen, Matthew C; Duker, Andrew P . Misleading Imaging and Clinical Features in Pathology-Proven Corticobasal Degeneration. Movement disorders clinical practice, 3 3, 315-317

Wissel, Benjamin D; Mitsi, Georgia; Dwivedi, Alok K; Papapetropoulos, Spyridon; Larkin, Sydney; López Castellanos, José Ricardo; Shanks, Emily; Duker, Andrew P; Rodriguez-Porcel, Federico; Vaughan, Jennifer E; Lovera, Lilia; Tsoulos, Ioannis; Stavrakoudis, Athanassios; Espay, Alberto J . Tablet-Based Application for Objective Measurement of Motor Fluctuations in Parkinson Disease. Digital biomarkers, 1 2, 126-135