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Photo of  Charles C. Caldwell, PhD

Charles C. Caldwell, PhD

Professor

Director, Division of Research

Surgery | College of Medicine

Education/Credentials
  • Postdoctoral Training: National Institutes of Health (Immunology)
  • Doctoral Degree: San Diego State University (Biochemistry)
  • Bachelor's Degree: University of California - San Diego (Chemistry)
Contact Information
Research Interests

Host Immune Response to Sepsis and Trauma Injury

Peer Reviewed Publications

Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M; Hammock, Bruce D 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proceedings of the National Academy of Sciences of the United States of America, 119 13, e2120691119

Pulliam, Kasiemobi E; Joseph, Bernadin; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A 2022. Improving packed red blood cell storage with a high-viscosity buffered storage solution. Surgery, 171 3, 833-842

Salyer, Christen E; Bergmann, Christian B; Hotchkiss, Richard S; Crisologo, Peter A; Caldwell, Charles C 2022. Functional Characterization of Neutrophils Allows Source Control Evaluation in a Murine Sepsis Model. The Journal of surgical research, 274 , 94-101

Wallen, Taylor E; Hanseman, Dennis; Caldwell, Charles C; Wang, Yao-Wei W; Wade, Charles E; Holcomb, John B; Pritts, Timothy A; Goodman, Michael D 2022. Survival analysis by inflammatory biomarkers in severely injured patients undergoing damage control resuscitation. Surgery, 171 3, 818-824

Zhang, Liyuan; Patel, Shailey; Soulakova, Julia N; Caldwell, Charles C; St Pierre Schneider, Barbara 2022. Mild hypobaric hypoxia influences splenic proliferation during the later phase of stress erythropoiesis. Experimental biology and medicine (Maywood, N.J.), 247 6, 509-518

Beckmann, Nadine; Schumacher, Fabian; Kleuser, Burkhard; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C 2021. Burn Injury Impairs Neutrophil Chemotaxis Through Increased Ceramide. Shock (Augusta, Ga.), 56 1, 125-132

Bergmann, Christian B; Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C 2021. Lymphocyte Immunosuppression and Dysfunction Contributing to Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS). Shock (Augusta, Ga.), 55 6, 723-741

Bergmann, Christian B; Beckmann, Nadine; Salyer, Christen E; Hanschen, Marc; Crisologo, Peter A; Caldwell, Charles C 2021. Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression. Frontiers in immunology, 12 , 622601

Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports, 11 1, 16555

Johnson, Lance J; Crisologo, Peter A; Sivaganesan, Siva; Caldwell, Charles C; Henning, Jordan 2021. Evaluation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for detecting necrotizing soft tissue infections in patients with diabetes and lower extremity infection. Diabetes research and clinical practice, 171 , 108520

Mazer, Monty B; Davitt, Ethan; Turnbull, Isaiah R; Caldwell, Charles C; Brakenridge, Scott C; Remy, Kenneth E; Hotchkiss, Richard S 2021. In Vitro-Administered Dexamethasone Suppresses T Cell Function With Reversal by Interleukin-7 in Coronavirus Disease 2019. Critical care explorations, 3 4, e0378

Mazer, Monty B; Turnbull, Isaiah R; Miles, Sydney; Blood, Teresa M; Sadler, Brooke; Hess, Annie; Botney, Mitchell D; Martin, Robert S; Bosanquet, James P; Striker, David A; Anand, Nitin S; Morre, Michel; Caldwell, Charles C; Brakenridge, Scott C; Moldawer, Lyle L; Di Paola, Jorge A; Hotchkiss, Richard S; Remy, Kenneth E 2021. Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report. Critical care explorations, 3 7, e0500

Pulliam, Kasiemobi E; Joseph, Bernadin; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A 2021. Washing packed red blood cells decreases red blood cell storage lesion formation. Surgery, 169 3, 666-670

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A 2021. Expired But Not Yet Dead: Examining the Red Blood Cell Storage Lesion in Extended-Storage Whole Blood. Shock (Augusta, Ga.), 55 4, 526-535

Baker, Jennifer E; Seitz, Aaron P; Boudreau, Ryan M; Skinner, Mitchell J; Beydoun, Ahmed; Kaval, Necati; Caldwell, Charles C; Gulbins, Erich; Edwards, Michael J; Gobble, Ryan M 2020. Doxycycline-Coated Silicone Breast Implants Reduce Acute Surgical-Site Infection and Inflammation. Plastic and reconstructive surgery, 146 5, 1029-1041

Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C 2020. Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling. Frontiers in immunology, 11 , 876

Beckmann, Nadine; Pugh, Amanda M; Auteri, Nicholas J; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C 2020. Therapeutic Inhaled Sphingosine for Treating Lung Infection in a Mouse Model of Critical Illness. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54 5, 1054-1067

Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C 2020. Staging and Personalized Intervention for Infection and Sepsis. Surgical infections, ,

Beckmann, Nadine; Sutton, Jeffrey M; Hoehn, Richard S; Jernigan, Peter L; Friend, Lou Ann; Johanningman, Taylor A; Schuster, Rebecca M; Lentsch, Alex B; Caldwell, Charles C; Pritts, Timothy A 2020. IFN? and TNF? mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation. American journal of physiology. Lung cellular and molecular physiology, 318 5, L864-L872

Bergmann, Christian B; Salyer, Christen E; Beckmann, Nadine; Caldwell, Charles C 2020. Intraperitoneal Neutrophil IL-10 production is promoted by interferon ? in a murine model of sepsis model in the acute phase of sepsis. Biochemical and biophysical research communications, 530 1, 278-284

Caldwell, Colleen C; Spies, Maria 2020. Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. Critical reviews in biochemistry and molecular biology, 55 5, 482-507

Jung, Andrew D; Friend, Lou Ann; Stevens-Topie, Sabre; Schuster, Rebecca; Lentsch, Alex B; Gavitt, Brian; Caldwell, Charles C; Pritts, Timothy A 2020. Direct Peritoneal Resuscitation Improves Survival in a Murine Model of Combined Hemorrhage and Burn Injury. Military medicine, 185 9-10, e1528-e1535

Kim, Young; Goodman, Michael D; Jung, Andrew D; Abplanalp, William A; Schuster, Rebecca M; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A 2020. Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin. Thrombosis research, 185 , 160-166

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B 2020. Fibrotic liver has prompt recovery after ischemia-reperfusion injury. American journal of physiology. Gastrointestinal and liver physiology, 318 3, G390-G400

Morris, Mackenzie C; John, Devin; Singer, Kathleen E; Moran, Ryan; McGlone, Emily; Veile, Rosalie; Goetzman, Holly S; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D 2020. Post-TBI splenectomy may exacerbate coagulopathy and platelet activation in a murine model. Thrombosis research, 193 , 211-217

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A 2020. SAVE IT - DON'T WASTE IT! MAXIMIZING UTILIZATION OF ERYTHROCYTES FROM PREVIOUSLY STORED WHOLE BLOOD. The journal of trauma and acute care surgery, ,

Remy, Kenneth E; Mazer, Monty; Striker, David A; Ellebedy, Ali H; Walton, Andrew H; Unsinger, Jacqueline; Blood, Teresa M; Mudd, Philip A; Yi, Daehan J; Mannion, Daniel A; Osborne, Dale F; Martin, R Scott; Anand, Nitin J; Bosanquet, James P; Blood, Jane; Drewry, Anne M; Caldwell, Charles C; Turnbull, Isaiah R; Brakenridge, Scott C; Moldawer, Lyle L; Hotchkiss, Richard S 2020. Severe immunosuppression and not a cytokine storm characterize COVID-19 infections. JCI insight, ,

Salyer, Christen E; Bomholt, Christina; Beckmann, Nadine; Bergmann, Christian B; Plattner, Courtney A; Caldwell, Charles C 2020. Novel Therapeutics for the Treatment of Burn Infection. Surgical infections, ,

Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa 2020. Distinct Neutrophil Populations in the Spleen During PICS. Frontiers in immunology, 11 , 804

Winer, Leah K; Salyer, Christen; Beckmann, Nadine; Caldwell, Charles C; Nomellini, Vanessa 2020. Enigmatic role of coagulopathy among sepsis survivors: a review of coagulation abnormalities and their possible link to chronic critical illness. Trauma surgery & acute care open, 5 1, e000462

Crouser, Elliott D; Caldwell, Charles C; Hotchkiss, Richard S 2019. What Is the Skinny on Obesity During Sepsis? Critical care medicine, 47 5, 735-736

Hefele, Friederike; Ditsch, Alexander; Krysiak, Niels; Caldwell, Charles C; Biberthaler, Peter; van Griensven, Martijn; Huber-Wagner, Stefan; Hanschen, Marc 2019. Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Platelet Dysfunction. Frontiers in immunology, 10 , 2389

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B 2019. Cell-specific regulatory effects of CXCR2 on cholestatic liver injury. American journal of physiology. Gastrointestinal and liver physiology, 317 6, G773-G783

Martin, Grace E; Pugh, Amanda M; Moran, Ryan; Veile, Rose; Friend, Lou Ann; Pritts, Timothy A; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D 2019. Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine diphosphate receptor. The journal of trauma and acute care surgery, 86 4, 592-600

Seitz, Aaron P; Schumacher, Fabian; Baker, Jennifer; Soddemann, Matthias; Wilker, Barbara; Caldwell, Charles C; Gobble, Ryan M; Kamler, Markus; Becker, Katrin Anne; Beck, Sascha; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich 2019. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia. Journal of molecular medicine (Berlin, Germany), 97 8, 1195-1211

Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa 2019. Consumptive coagulopathy is associated with organ dysfunction during PICS. American journal of physiology. Lung cellular and molecular physiology, 316 5, L946-L952

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C 2019. Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. Shock (Augusta, Ga.), 51 3, 356-363

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C 2019. Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 52 3, 565-579

Becker, Katrin Anne; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Caldwell, Charles C; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich 2018. Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide. Infection and immunity, 86 1,

Becker, Katrin Anne; Riethmüller, Joachim; Seitz, Aaron P; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C; Edwards, Michael J; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich 2018. Sphingolipids as targets for inhalation treatment of cystic fibrosis. Advanced drug delivery reviews, 133 , 66-75

Beckmann, Nadine; Pugh, Amanda M; Caldwell, Charles C 2018. Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression. PloS one, 13 10, e0205307

Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P; Edwards, Michael J; Goodman, Michael; Caldwell, Charles C; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich 2018. Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide. Molecular psychiatry, 23 12, 2324-2346

Keitsch, Simone; Riethmüller, Joachim; Soddemann, Matthias; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Gulbins, Erich; Becker, Katrin Anne 2018. Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin. Biological chemistry, 399 10, 1203-1213

Kim, Young; Abplanalp, William A; Jung, Andrew D; Schuster, Rebecca M; Lentsch, Alex B; Gulbins, Erich; Caldwell, Charles C; Pritts, Timothy A 2018. Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5. Shock (Augusta, Ga.), 49 3, 288-294

Kim, Young; Xia, Brent T; Jung, Andrew D; Chang, Alex L; Abplanalp, William A; Caldwell, Charles C; Goodman, Michael D; Pritts, Timothy A 2018. Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion. Surgery, 163 2, 423-429

Martin, Grace E; Xia, Brent; Kim, Young; Johnson, Mark D; Veile, Rosalie; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D 2018. Platelet Function Changes in a Time-Dependent Manner Following Traumatic Brain Injury in a Murine Model. Shock (Augusta, Ga.), 50 5, 551-556

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang 2018. Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation. Shock (Augusta, Ga.), 49 4, 429-441

Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C 2018. Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished? Shock (Augusta, Ga.), 49 1, 4-14

Becker, Katrin Anne; Li, Xiang; Seitz, Aaron; Steinmann, Joerg; Koch, Anne; Schuchman, Edward; Kamler, Markus; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich 2017. Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 4, 1603-1616

Boudreau, Ryan M; Johnson, Mark; Veile, Rosalie; Friend, Lou Ann; Goetzman, Holly; Pritts, Timothy A; Caldwell, Charles C; Makley, Amy T; Goodman, Michael D 2017. Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhage. The Journal of surgical research, 215 , 47-54

Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P; Steinmann, Joerg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H; Caldwell, Charles C; Kamler, Markus; Edwards, Michael J; Brodlie, Malcolm; Gulbins, Erich 2017. ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections. Cell host & microbe, 21 6, 707-718.e8

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A 2017. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Annals of surgery, 265 1, 218-226

Johnson, Bobby L; Midura, Emily F; Prakash, Priya S; Rice, Teresa C; Kunz, Natalia; Kalies, Kathrin; Caldwell, Charles C 2017. Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis. Biochimica et biophysica acta. Molecular basis of disease, 1863 10 Pt B, 2554-2563

Kunz, Natalia; Hauenschild, Eva; Maass, Sebastian; Kalies, Kai-Uwe; Klinger, Matthias; Barra, Melanie; Hecht, Lars; Helbig, Franz; Soellner, Stefan; Caldwell, Charles C; Ludwig, Ralf J; Westermann, Jürgen; Kalies, Kathrin 2017. Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin. Experimental dermatology, 26 12, 1199-1206

Kunz, Natalia; Xia, Brent T; Kalies, Kai-Uwe; Klinger, Matthias; Gemoll, Timo; Habermann, Jens K; Whitacre, Brynne E; Seitz, Aaron P; Kalies, Kathrin; Caldwell, Charles C 2017. Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis With Therapeutic Potential. Shock (Augusta, Ga.), 48 3, 346-354

Ma, Jie; Gulbins, Erich; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Becker, Katrin Anne 2017. Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43 6, 2170-2184

Martin, Grace E; Boudreau, Ryan M; Couch, Caroline; Becker, Katrin Anne; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Seitz, Aaron 2017. Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic. Biochimie, 141 , 91-96

Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa 2017. A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome. International journal of molecular sciences, 18 8,

Rice, Teresa C; Armocida, Stephanie M; Kuethe, Joshua W; Midura, Emily F; Jain, Ayushi; Hildeman, David A; Healy, Daniel P; Gulbins, Erich; Caldwell, Charles C 2017. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner. Cellular immunology, 313 , 25-31

Rice, Teresa C; Pugh, Amanda M; Caldwell, Charles C; Schneider, Barbara St Pierre 2017. Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Sepsis. Critical care nursing clinics of North America, 29 3, 331-340

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C 2017. Sphingosine rescues aged mice from pulmonary pseudomonas infection. The Journal of surgical research, 219 , 354-359

Rice, Teresa C; Pugh, Amanda M; Xia, Brent T; Seitz, Aaron P; Whitacre, Brynne E; Gulbins, Erich; Caldwell, Charles C 2017. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection. Journal of the American College of Surgeons, 225 4, 538-547

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A 2016. Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 39 1, 331-40

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A 2016. Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation. Annals of surgery, ,

Johnson, Bobby L; Rice, Teresa C; Xia, Brent T; Boone, Kirsten I; Green, Ellis A; Gulbins, Erich; Caldwell, Charles C 2016. Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury. Shock (Augusta, Ga.), ,

Kuethe, Joshua W; Armocida, Stephanie M; Midura, Emily F; Rice, Teresa C; Hildeman, David A; Healy, Daniel P; Caldwell, Charles C 2016. Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury. Shock (Augusta, Ga.), 45 6, 647-52

Midura, Emily F; Kuethe, Joshua W; Rice, Teresa C; Veile, Rosalie; England, Lisa G; Friend, Lou Ann; Caldwell, Charles C; Goodman, Michael D 2016. Impact of Platelets and Platelet-Derived Microparticles on Hypercoagulability Following Burn Injury. Shock (Augusta, Ga.), 45 1, 82-7

Midura, Emily F; Prakash, Priya S; Johnson, Bobby L; Rice, Teresa C; Kunz, Natalia; Caldwell, Charles C 2016. Impact of caspase-8 and PKA in regulating neutrophil-derived microparticle generation. Biochemical and biophysical research communications, 469 4, 917-22

Rice, Teresa C; Seitz, Aaron P; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C 2016. Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection. Journal of leukocyte biology, ,

Kuethe, Joshua W; Midura, Emily F; Rice, Teresa C; Caldwell, Charles C 2015. Peritoneal wash contents used to predict mortality in a murine sepsis model. The Journal of surgical research, ,

Midura, Emily F; Jernigan, Peter L; Kuethe, Joshua W; Friend, Lou Ann; Veile, Rosalie; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D 2015. Microparticles impact coagulation after traumatic brain injury. The Journal of surgical research, 197 1, 25-31

Siegl, Daniel; Midura, Emily F; Annecke, Thorsten; Conzen, Peter; Caldwell, Charles C; Tschoep, Johannes 2015. The effect of ghrelin upon the early immune response in lean and obese mice during sepsis. PloS one, 10 4, e0122211

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang 2015. Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis. Scientific reports, 5 , 13721

Wilson, Gregory C; Freeman, Christopher M; Kuethe, Joshua W; Quillin, Ralph C; Nojima, Hiroyuki; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B 2015. CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice. American journal of physiology. Gastrointestinal and liver physiology, 308 8, G702-9

Freeman, Christopher M; Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Johnson, Bobby L; Sutton, Jeffrey M; Schuster, Rebecca M; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B 2014. Characterization of microparticles after hepatic ischemia-reperfusion injury. PloS one, 9 5, e97945

Johnson, Bobby L; Iii, ; Kuethe, Josh W; Caldwell, Charles C 2014. Neutrophil derived microvesicles: emerging role of a key mediator to the immune response. Endocrine, metabolic & immune disorders drug targets, 14 3, 210-7

Kuethe, Joshua W; Prakash, Priya S; Midura, Emily F; Johnson, Bobby L; Kasten, Kevin R; Caldwell, Charles C 2014. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. The Journal of surgical research, 191 1, 19-24

Lehmann, Christian; Sharawi, Nivin; Al-Banna, Nadia; Corbett, Nathan; Kuethe, Joshua W; Caldwell, Charles C 2014. Novel approaches to the development of anti-sepsis drugs. Expert opinion on drug discovery, 9 5, 523-31

Siegl, Daniel; Annecke, Thorsten; Johnson, Bobby L; Schlag, Christian; Martignoni, Andre; Huber, Nadine; Conzen, Peter; Caldwell, Charles C; Tschöp, Johannes 2014. Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis. Anesthesiology, 121 1, 98-114

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang 2014. Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis. Biochimica et biophysica acta, 1842 5, 701-11

Yang, Sung; Stepien, David; Hanseman, Dennis; Robinson, Bryce; Goodman, Michael D; Pritts, Timothy A; Caldwell, Charles C; Remick, Daniel G; Lentsch, Alex B 2014. Substance P mediates reduced pneumonia rates after traumatic brain injury. Critical care medicine, 42 9, 2092-100

Johnson, Bobby L; Goetzman, Holly S; Prakash, Priya S; Caldwell, Charles C 2013. Mechanisms underlying mouse TNF-? stimulated neutrophil derived microparticle generation. Biochemical and biophysical research communications, 437 4, 591-6

Van Sweringen, Heather L; Sakai, Nozomu; Quillin, Ralph C; Bailey, Jeff; Schuster, Rebecca; Blanchard, John; Goetzman, Holly; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B 2013. Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice. Hepatology (Baltimore, Md.), 57 1, 331-8

Belizaire, Ritha M; Prakash, Priya S; Richter, Jillian R; Robinson, Bryce R; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A 2012. Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation. Journal of the American College of Surgeons, 214 4, 648-55; discussion 6

Nowak, Jeffrey E; Harmon, Kelli; Caldwell, Charles C; Wong, Hector R 2012. Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13 5, e323-9

Prakash, Priya S; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A; Robinson, Bryce R H 2012. Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response. The journal of trauma and acute care surgery, 73 2, 401-6; discussion 40

Standage, Stephen W; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector R 2012. Reduced peroxisome proliferator-activated receptor ? expression is associated with decreased survival and increased tissue bacterial load in sepsis. Shock (Augusta, Ga.), 37 2, 164-9

Unsinger, Jacqueline; Burnham, Carey-Ann D; McDonough, Jacquelyn; Morre, Michel; Prakash, Priya S; Caldwell, Charles C; Dunne, W Michael; Hotchkiss, Richard S 2012. Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. The Journal of infectious diseases, 206 4, 606-16

Caldwell, Charles C; Hotchkiss, Richard S 2011. The first step in utilizing immune-modulating therapies: immune status determination. Critical care (London, England), 15 1, 108

Clarke, Callisia; Kuboki, Satoshi; Sakai, Nozomu; Kasten, Kevin R; Tevar, Amit D; Schuster, Rebecca; Blanchard, John; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B 2011. CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury. Hepatology (Baltimore, Md.), 53 1, 261-71

Adediran, Samuel G; Dauplaise, Derrick J; Kasten, Kevin R; Tschöp, Johannes; Dattilo, Jonathan; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Robinson, Chad T; Caldwell, Charles C 2010. Early infection during burn-induced inflammatory response results in increased mortality and p38-mediated neutrophil dysfunction. American journal of physiology. Regulatory, integrative and comparative physiology, 299 3, R918-25

Kasten, Kevin R; Goetzman, Holly S; Reid, Maria R; Rasper, Alison M; Adediran, Samuel G; Robinson, Chad T; Cave, Cindy M; Solomkin, Joseph S; Lentsch, Alex B; Johannigman, Jay A; Caldwell, Charles C 2010. Divergent adaptive and innate immunological responses are observed in humans following blunt trauma. BMC immunology, 11 , 4

Kasten, Kevin R; Muenzer, Jared T; Caldwell, Charles C 2010. Neutrophils are significant producers of IL-10 during sepsis. Biochemical and biophysical research communications, 393 1, 28-31

Kasten, Kevin R; Prakash, Priya S; Unsinger, Jacqueline; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Seitz, Aaron P; Mazuski, Cristina N; Zhou, Tony T; Morre, Michel; Hotchkiss, Richard S; Hildeman, David A; Caldwell, Charles C 2010. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infection and immunity, 78 11, 4714-22

Kasten, Kevin R; Tschöp, Johannes; Adediran, Samuel G; Hildeman, David A; Caldwell, Charles C 2010. T cells are potent early mediators of the host response to sepsis. Shock (Augusta, Ga.), 34 4, 327-36

Kasten, Kevin R; Tschöp, Johannes; Goetzman, Holly S; England, Lisa G; Dattilo, Jonathan R; Cave, Cindy M; Seitz, Aaron P; Hildeman, David A; Caldwell, Charles C 2010. T-cell activation differentially mediates the host response to sepsis. Shock (Augusta, Ga.), 34 4, 377-83

Kasten, Kevin Richard; Tschöp, Johannes; Tschöp, Matthias Hans; Caldwell, Charles Curtis 2010. The cannabinoid 2 receptor as a potential therapeutic target for sepsis. Endocrine, metabolic & immune disorders drug targets, 10 3, 224-34

Tschöp, Johannes; Dattilo, Jonathan R; Prakash, Priya S; Kasten, Kevin R; Tschöp, Matthias H; Caldwell, Charles C 2010. The leptin system: a potential target for sepsis induced immune suppression. Endocrine, metabolic & immune disorders drug targets, 10 4, 336-47

Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H 2010. CNS leptin action modulates immune response and survival in sepsis. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 17, 6036-47

Unsinger, Jacqueline; McGlynn, Margaret; Kasten, Kevin R; Hoekzema, Andrew S; Watanabe, Eizo; Muenzer, Jared T; McDonough, Jacquelyn S; Tschoep, Johannes; Ferguson, Thomas A; McDunn, Jonathan E; Morre, Michel; Hildeman, David A; Caldwell, Charles C; Hotchkiss, Richard S 2010. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 184 7, 3768-79

Caldwell, Charles C; Chen, Yi; Goetzmann, Holly S; Hao, Yonghua; Borchers, Michael T; Hassett, Daniel J; Young, Lisa R; Mavrodi, Dmitri; Thomashow, Linda; Lau, Gee W 2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis. The American journal of pathology, 175 6, 2473-88

Hassett, Daniel J; Sutton, Mark D; Schurr, Michael J; Herr, Andrew B; Caldwell, Charles C; Matu, Joseph O 2009. Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. Trends in microbiology, 17 3, 130-8

Kuboki, Satoshi; Sakai, Nozomu; Tschöp, Johannes; Edwards, Michael J; Lentsch, Alex B; Caldwell, Charles C 2009. Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury. American journal of physiology. Gastrointestinal and liver physiology, 296 5, G1054-9

Tschöp, Johannes; Kasten, Kevin R; Nogueiras, Ruben; Goetzman, Holly S; Cave, Cynthia M; England, Lisa G; Dattilo, Jonathan; Lentsch, Alex B; Tschöp, Matthias H; Caldwell, Charles C 2009. The cannabinoid receptor 2 is critical for the host response to sepsis. Journal of immunology (Baltimore, Md. : 1950), 183 1, 499-505

Tschöp, Johannes; Martignoni, André; Reid, Maria D; Adediran, Samuel G; Gardner, Jason; Noel, Greg J; Ogle, Cora K; Neely, Alice N; Caldwell, Charles C 2009. Differential immunological phenotypes are exhibited after scald and flame burns. Shock (Augusta, Ga.), 31 2, 157-63

Caldwell, Charles C; Lentsch, Alex B 2008. Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion. Gastroenterology, 135 5, 1460-2

Caldwell, Charles C; Martignoni, Andre; Leonis, Mike A; Ondiveeran, Hari Kumar; Fox-Robichaud, Alison E; Waltz, Susan E 2008. Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis. Critical care medicine, 36 5, 1585-93

Martignoni, André; Tschöp, Johannes; Goetzman, Holly S; Choi, Lisa G; Reid, Maria D; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C 2008. CD4-expressing cells are early mediators of the innate immune system during sepsis. Shock (Augusta, Ga.), 29 5, 591-7

Tschöp, Johannes; Martignoni, André; Goetzman, Holly S; Choi, Lisa G; Wang, Quan; Noel, John G; Ogle, Cora K; Pritts, Timothy A; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C 2008. Gammadelta T cells mitigate the organ injury and mortality of sepsis. Journal of leukocyte biology, 83 3, 581-8

Caldwell, Charles C; Tschoep, Johannes; Lentsch, Alex B 2007. Lymphocyte function during hepatic ischemia/reperfusion injury. Journal of leukocyte biology, 82 3, 457-64

Huang, Julie H; Cárdenas-Navia, L Isabel; Caldwell, Charles C; Plumb, Troy J; Radu, Caius G; Rocha, Paulo N; Wilder, Tuere; Bromberg, Jonathan S; Cronstein, Bruce N; Sitkovsky, Michail; Dewhirst, Mark W; Dustin, Michael L 2007. Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950), 178 12, 7747-55

Noel, John G; Osterburg, Andrew; Wang, Quan; Guo, Xialing; Byrum, Denise; Schwemberger, Sandy; Goetzman, Holly; Caldwell, Charles C; Ogle, Cora K 2007. Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments. Shock (Augusta, Ga.), 28 6, 684-93

Thiel, Manfred; Caldwell, Charles C; Kreth, Simone; Kuboki, Satoshi; Chen, P; Smith, Patrick; Ohta, Akio; Lentsch, Alex B; Lukashev, Dmitry; Sitkovsky, Michail V 2007. Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. PloS one, 2 9, e853

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E 2007. Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury. American journal of physiology. Gastrointestinal and liver physiology, 292 1, G253-61

Caldwell, Charles C; Okaya, Tomohisa; Martignoni, Andre; Husted, Thomas; Schuster, Rebecca; Lentsch, Alex B 2005. Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion. American journal of physiology. Gastrointestinal and liver physiology, 289 5, G969-76

Noel, John G; Guo, Xialing; Wells-Byrum, Denise; Schwemberger, Sandy; Caldwell, Charles C; Ogle, Cora K 2005. Effect of thermal injury on splenic myelopoiesis. Shock (Augusta, Ga.), 23 2, 115-22

Okaya, Tomohisa; Blanchard, John; Schuster, Rebecca; Kuboki, Satoshi; Husted, Thomas; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector; Solomkin, Joseph S; Lentsch, Alex B 2005. Age-dependent responses to hepatic ischemia/reperfusion injury. Shock (Augusta, Ga.), 24 5, 421-7

Lukashev, Dmitriy E; Caldwell, Charles C; Chen, Pearl; Apasov, Sergey G; Margulies, David H; Sitkovsky, Michail V 2003. A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen. Journal of receptor and signal transduction research, 23 1, 33-52

Lukashev, Dmitriy E; Smith, Patrick T; Caldwell, Charles C; Ohta, Akio; Apasov, Sergey G; Sitkovsky, Michail V 2003. Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs. Biochemical pharmacology, 65 12, 2081-90

Olah, Mark E; Caldwell, Charles C 2003. Adenosine receptors and mammalian toll-like receptors: synergism in macrophages. Molecular interventions, 3 7, 370-4

Thiel, Manfred; Caldwell, Charles C; Sitkovsky, Michail V 2003. The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes and infection / Institut Pasteur, 5 6, 515-26

Wen, Long T; Caldwell, Charles C; Knowles, Aileen F 2003. Poly(ADP-ribose) polymerase activation and changes in Bax protein expression associated with extracellular ATP-mediated apoptosis in human embryonic kidney 293-P2X7 cells. Molecular pharmacology, 63 3, 706-13

Kojima, Hidefumi; Gu, Hua; Nomura, Saeko; Caldwell, Charles C; Kobata, Tetsuji; Carmeliet, Peter; Semenza, Gregg L; Sitkovsky, Michail V 2002. Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proceedings of the National Academy of Sciences of the United States of America, 99 4, 2170-4

Caldwell, C C; Hornyak, S C; Pendleton, E; Campbell, D; Knowles, A F 2001. Regulation of chicken gizzard ecto-ATPase activity by modulators that affect its oligomerization status. Archives of biochemistry and biophysics, 387 1, 107-16

Caldwell, C C; Kojima, H; Lukashev, D; Armstrong, J; Farber, M; Apasov, S G; Sitkovsky, M V 2001. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. Journal of immunology (Baltimore, Md. : 1950), 167 11, 6140-9

Zhou, P; Freidag, B L; Caldwell, C C; Seder, R A 2001. Perforin is required for primary immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), 166 3, 1968-74

Caldwell, C C; Davis, M D; Knowles, A F 1999. Ectonucleotidases of avian gizzard smooth muscle and liver plasma membranes: a comparative study. Archives of biochemistry and biophysics, 362 1, 46-58

Redegeld, F A; Caldwell, C C; Sitkovsky, M V 1999. Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation? Trends in pharmacological sciences, 20 11, 453-9

Hurt, R D; Dale, L C; Fredrickson, P A; Caldwell, C C; Lee, G A; Offord, K P; Lauger, G G; Mar?si?, Z; Neese, L W; Lundberg, T G 1994. Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. JAMA, 271 8, 595-600

Myers, T F; Patrinos, M E; Muraskas, J; Caldwell, C C; Lambert, G H; Anderson, C L 1987. Dynamic trend monitoring of cerebral blood flow velocity in newborn infants. The Journal of pediatrics, 110 4, 611-6

Caldwell, C C; Hurley, R M; Anderson, C L; Ahmed, G S; Myers, T F 1985. Nonimmune hydrops fetalis managed with peritoneal dialysis. American journal of perinatology, 2 3, 211-3

Caldwell, C C; Stankiewicz, J; Anderson, C L; Ahmed, G S; Myers, T F 1985. Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment. American journal of diseases of children (1960), 139 6, 618-20

Anderson, C L; Collin, M F; O'Keefe, J P; Challapalli, M; Myers, T F; Caldwell, C C; Ahmed, G S 1984. A widespread epidemic of mild necrotizing enterocolitis of unknown cause. American journal of diseases of children (1960), 138 10, 979-83

Puczynski, M S; Dvonch, V M; Menendez, C E; Caldwell, C C 1984. Osteomyelitis of the great toe secondary to phlebotomy. Clinical orthopaedics and related research, 190, 239-40

Caldwell, C C; Levkoff, A H; Purohit, D M 1977. Paroxysmal supraventricular tachycardia in a neonate: a complication of racemic epinephrine inhalation for post-extubation stridor. Clinical pediatrics, 16 6, 579-80

Purohit, D M; Caldwell, C C; Webb, H N; Levkoff, A H 1976. Effects of assisted ventilation on echocardiographic findings in two infants with patent ductus arteriosus. The Journal of thoracic and cardiovascular surgery, 72 2, 294-5

Lukashev D.;Caldwell C.;Ohta A.;Chen P.;Sitkovsky M. 12-28-2001. Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1? in Acti Journal of Biological Chemistry, 276 52, 48754-48763

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. 12-01-2018. Antidepressants regulate autophagy by targeting acid sphingomyelinase Molecular Psychiatry, 23 12, 2251

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. 12-01-2018. Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide Molecular Psychiatry, 23 12, 2324-2346

Kunz N.;Hauenschild E.;Maass S.;Kalies K.U.;Klinger M.;Barra M.;Hecht L.;Helbig F.;Soellner S.;Caldwell C.C.;Ludwig R.J.;Westermann J.;Kalies K. 12-01-2017. Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and Experimental Dermatology, 26 12, 1199-1206

Ma J.;Gulbins E.;Edwards M.;Caldwell C.;Fraunholz M.;Becker K. 12-01-2017. Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Cellular Physiology and Biochemistry, 43 6, 2170-2184

Caldwell C.;Hornyak S.;Stephen Dahms A. 12-01-1998. Probes at the chicken smooth muscle ECTO-ATPASE: A comprehensive regulatory model FASEB Journal, 12 8,

Stitt O.L.;Davis M.;Caldwell C.;Dahms A.S. 12-01-1998. Kinetic differentiation of ecto-aptase sub-families from chicken smooth muscle and liver FASEB Journal, 12 8,

Caldwell C.;Campbell D.;Gospaderic T.;Dahms A. 12-01-1997. Modulation of smooth muscle ecto-atpase activity by lipid covalent/ non-covalent probes FASEB Journal, 11 9,

Baker J.;Boudreau R.;Seitz A.;Caldwell C.;Gulbins E.;Edwards M. 11-01-2018. Sphingolipids and innate immunity: A new approach to infection in the post-antibiotic era? Surgical Infections, 19 8, 792-803

Becker K.;Li X.;Seitz A.;Steinmann J.;Koch A.;Schuchman E.;Kamler M.;Edwards M.;Caldwell C.;Gulbins E. 11-01-2017. Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine Cellular Physiology and Biochemistry, 43 4, 1603-1616

Rice T.;Pugh A.;Seitz A.;Gulbins E.;Nomellini V.;Caldwell C. 11-01-2017. Sphingosine rescues aged mice from pulmonary pseudomonas infection Journal of Surgical Research, 219 , 354-359

Hefele F.;Ditsch A.;Krysiak N.;Caldwell C.;Biberthaler P.;van Griensven M.;Huber-Wagner S.;Hanschen M. 10-11-2019. Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Plate Frontiers in Immunology, 10 ,

Beckmann N.;Pugh A.;Caldwell C. 10-01-2018. Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression PLoS ONE, 13 10,

Johnson B.L.;Midura E.F.;Prakash P.S.;Rice T.C.;Kunz N.;Kalies K.;Caldwell C.C. 10-01-2017. Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a muri Biochimica et Biophysica Acta - Molecular Basis of Disease, 1863 10, 2554-2563

Martin G.;Boudreau R.;Couch C.;Becker K.;Edwards M.;Caldwell C.;Gulbins E.;Seitz A. 10-01-2017. Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic Biochimie, 141 , 91-96

Rice T.;Pugh A.;Xia B.;Seitz A.;Whitacre B.;Gulbins E.;Caldwell C. 10-01-2017. Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection Journal of the American College of Surgeons, 225 4, 538-547

Caldwell C.;Norman V.;Urbina A.;Jarvis A.;Quinonez C.;Stemm M.;Dahms A.S. 09-29-1997. Regulatory differences among avian Ecto-ATPases Biochemical and Biophysical Research Communications, 238 3, 728-732

Keitsch S.;Riethmüller J.;Soddemann M.;Sehl C.;Wilker B.;Edwards M.;Caldwell C.;Fraunholz M.;Gulbins E.;Becker K. 09-25-2018. Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-Toxi Biological Chemistry, 399 10, 1203-1213

Kunz N.;Xia B.T.;Kalies K.U.;Klinger M.;Gemoll T.;Habermann J.K.;Whitacre B.E.;Seitz A.P.;Kalies K.;Caldwell C.C. 09-01-2017. Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis with Therapeutic Potential Shock, 48 3, 346-354

Rice T.;Pugh A.;Caldwell C.;Schneider B. 09-01-2017. Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Critical Care Nursing Clinics of North America, 29 3, 331-340

Pugh A.;Auteri N.;Goetzman H.;Caldwell C.;Nomellini V. 08-10-2017. A murine model of persistent inflammation, immune suppression, and catabolism syndrome International Journal of Molecular Sciences, 18 8,

Seitz A.P.;Schumacher F.;Baker J.;Soddemann M.;Wilker B.;Caldwell C.C.;Gobble R.M.;Kamler M.;Becker K.A.;Beck S.;Kleuser B.;Edwards M.J.;Gulbins E. 08-01-2019. Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia Journal of Molecular Medicine, 97 8, 1195-1211

Becker K.A.;Riethmüller J.;Seitz A.P.;Gardner A.;Boudreau R.;Kamler M.;Kleuser B.;Schuchman E.;Caldwell C.C.;Edwards M.J.;Grassmé H.;Brodlie M.;Gulbins E. 08-01-2018. Sphingolipids as targets for inhalation treatment of cystic fibrosis Advanced Drug Delivery Reviews, 133 , 66-75

Boudreau R.M.;Johnson M.;Veile R.;Friend L.A.;Goetzman H.;Caldwell C.C.;Makley A.T.;Goodman M.D. 07-01-2017. Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury Journal of Surgical Research, 215 , 47-54

Grassmé H.;Henry B.;Ziobro R.;Becker K.A.;Riethmüller J.;Gardner A.;Seitz A.P.;Steinmann J.;Lang S.;Ward C.;Schuchman E.H.;Caldwell C.C.;Kamler M.;Edwards M.J.;Brodlie M.;Gulbins E. 06-14-2017. ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingo Cell Host and Microbe, 21 6, 707-718.e8

Sitkovsky M.;Lukashev D.;Apasov S.;Kojima H.;Koshiba M.;Caldwell C.;Ohta A.;Thiel M. 06-07-2004. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors Annual Review of Immunology, 22 , 657-682

Thiel M.;Chouker A.;Ohta A.;Jackson E.;Caldwell C.;Smith P.;Lukashev D.;Bittmann I.;Sitkovsky M. 06-01-2005. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inf PLoS Biology, 3 6, 1088-1100

Crouser E.;Caldwell C.;Hotchkiss R. 05-01-2019. What Is the Skinny on Obesity during Sepsis? Critical Care Medicine, 47 5, 735-736

Winer L.;Beckmann N.;Veile R.;Goodman M.;Caldwell C.;Nomellini V. 05-01-2019. Consumptive coagulopathy is associated with organ dysfunction during PICS American Journal of Physiology - Lung Cellular and Molecular Physiology, 316 5, L946-L952

Martin G.E.;Pugh A.M.;Moran R.;Veile R.;Friend L.A.;Pritts T.A.;Makley A.T.;Caldwell C.C.;Goodman M.D. 04-01-2019. Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine d Journal of Trauma and Acute Care Surgery, 86 4, 592-599

Mu X.;Wang X.;Huang W.;Wang R.;Essandoh K.;Li Y.;Pugh A.;Peng J.;Deng S.;Wang Y.;Caldwell C.;Peng T.;Yu K.;Fan G. 04-01-2018. Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promo Shock, 49 4, 429-441

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. 03-01-2020. Fibrotic liver has prompt recovery after ischemia-reperfusion injury American journal of physiology. Gastrointestinal and liver physiology, 318 3, G390-G400

Xia B.T.;Beckmann N.;Winer L.K.;Kim Y.;Goetzman H.S.;Veile R.E.;Gulbins E.;Goodman M.D.;Nomellini V.;Caldwell C.C. 03-01-2019. Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy Shock, 51 3, 356-363

Kim Y.;Abplanalp W.;Jung A.;Schuster R.;Lentsch A.;Gulbins E.;Caldwell C.;Pritts T. 03-01-2018. Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5 Shock, 49 3, 288-294

Rice T.;Armocida S.;Kuethe J.;Midura E.;Jain A.;Hildeman D.;Healy D.;Gulbins E.;Caldwell C. 03-01-2017. Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner Cellular Immunology, 313 , 25-31

Armstrong J.M.;Chen J.F.;Schwarzschild M.A.;Apasov S.;Smith P.T.;Caldwell C.;Chen P.;Figler H.;Sullivan G.;Fink S.;Linden J.;Sitkovsky M. 02-15-2001. Gene dose effect reveals G<inf>S</inf>-coupled A<inf>2A</inf> adenosine rece Biochemical Journal, 354 1, 123-130

Kim Y.;Xia B.;Jung A.;Chang A.;Abplanalp W.;Caldwell C.;Goodman M.;Pritts T. 02-01-2018. Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of tran Surgery (United States), 163 2, 423-429

Kim Y.;Goodman M.;Jung A.;Abplanalp W.;Schuster R.;Caldwell C.;Lentsch A.;Pritts T. 01-01-2020. Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via Thrombosis Research, 185 , 160-166

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. 01-01-2019. Cell-specific regulatory effects of CXCR2 on cholestatic liver injury American Journal of Physiology - Gastrointestinal and Liver Physiology, 317 6, G773-G783

Xia B.;Beckmann N.;Winer L.;Pugh A.;Pritts T.;Nomellini V.;Gulbins E.;Caldwell C. 01-01-2019. Amitriptyline reduces inflammation and mortality in a murine model of sepsis Cellular Physiology and Biochemistry, 52 3, 565-579

Becker K.;Fahsel B.;Kemper H.;Mayeres J.;Li C.;Wilker B.;Keitsch S.;Soddemann M.;Sehl C.;Kohnen M.;Edwards M.;Grassmé H.;Caldwell C.;Seitz A.;Fraunholz M.;Gulbins E. 01-01-2018. Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinas Infection and Immunity, 86 1,

Martin G.;Xia B.;Kim Y.;Johnson M.;Veile R.;Friend L.;Makley A.;Caldwell C.;Goodman M. 01-01-2018. Platelet function changes in a time-dependent manner following traumatic brain injury in a murine mo Shock, 50 5, 551-556

Nomellini V.;Kaplan L.;Sims C.;Caldwell C. 01-01-2018. Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, S Shock, 49 1, 4-14

Hoehn R.;Jernigan P.;Japtok L.;Chang A.;Midura E.;Caldwell C.;Kleuser B.;Lentsch A.;Edwards M.;Gulbins E.;Pritts T. 01-01-2017. Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflamma Annals of Surgery, 265 1, 218-226

Lehmann C.;Burkovskiy I.;Kuethe J.;Zhou J.;Caldwell C.;Kelly M. 01-01-2014. Inhibition of the cannabinoid 2 receptor in CNS-injury induced immunodeficiency syndrome Medical Hypotheses, 82 6, 736-739

Siegmann N.;Worbs D.;Effinger F.;Bormann T.;Gebhardt M.;Ulrich M.;Wermeling F.;Müller-Hermelink E.;Biedermann T.;Tighe M.;Edwards M.;Caldwell C.;Leadbetter E.;Karlsson M.;Becker K.;Gulbins E.;Döring G. 01-01-2014. Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in c Cellular Physiology and Biochemistry, 34 1, 56-70

Caldwell C.C.;Chen Y.;Goetzmann H.S.;Hao Y.;Borchers M.T.;Hassett D.J.;Young L.R.;Mavrodi D.;Thomashow L.;Lau G.W. 01-01-2009. Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis American Journal of Pathology, 175 6, 2473-2488

Nogueiras R.;Veyrat-Durebex C.;Suchanek P.M.;Klein M.;Tschöp J.;Caldwell C.;Woods S.C.;Wittmann G.;Watanabe M.;Liposits Z.;Fekete C.;Reizes O.;Rohner-Jeanrenaud F.;Tschöp M.H. 01-01-2008. Peripheral, but Not Central, CB1 antagonism provides food intake-independent metabolic benefits in d Diabetes, 57 11, 2977-2991

Shivakumar P.;Sabla G.;Mohanty S.;McNeal M.;Ward R.;Stringer K.;Caldwell C.;Chougnet C.;Bezerra J. 01-01-2007. Effector Role of Neonatal Hepatic CD8<sup>+</sup> Lymphocytes in Epithelial Injury and A Gastroenterology, 133 1, 268-277

Baker, Jennifer E; Boudreau, Ryan M; Seitz, Aaron P; Caldwell, Charles C; Gulbins, Erich; Edwards, Michael J . Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era? Surgical infections, 19 8, 792-803

Kuethe, Joshua W; Mintz-Cole, Rachael; Johnson, Bobby L; Midura, Emily F; Caldwell, Charles C; Schneider, Barbara St Pierre . Assessing the immune status of critically ill trauma patients by flow cytometry. Nursing research, 63 6, 426-34