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Department of Internal Medicine

Nephrology and Hypertension

Photo of  John Galla, MD

John Galla, MD

Emeritus of Nephrology

Education/Credentials
  • Bachelor's Degree: U.S. Naval Academy
  • Medical Degree: Cornell University Medical College
  • Residency: University of California, San Francisco

Board Certifications & Licenses
  • Diplomate National Board of Medical Examiners, 1968
  • Diplomate American Board of Internal Medicine, 1972
  • Diplomate American Board of Internal Medicine - Nephrology, 1976
  • Renal Physicians Association Health Management Program - Fuqua School of Business - Duke University, 2004
  • Medical License Ohio State Medical Board, 1989
  • Medical License Indiana State Medical Board, 1989
Contact Information
  • Medical Science Building
  • Room G259
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0585
  • Office 513-558-5471
  • Fax 513-558-4309
  • Email john.galla@uc.edu

Peer Reviewed Publications

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Luke RG, Galla JH 2012. It is chloride depletion - not "contraction" - alkalosis J Am Soc Nephrol, 23 , 204-207

Adrogue HJ, Gennari FJ, Galla JH, Madais NE 2009. Assessing acid-base disorders Kidney Int, 76 , 1239-1247

Luke RG, Galla JH 2000. Economics of an academic renal division: an approach Semin Nephrol, 20 , 556-564

Nakamura S, Amlal H, Soleimani M, Galla J 2000. Pathways for HCO3-reabsorption in mouse medullary collecting duct segments J Lab Clin Med, 136 , 218-223

Luke RG, Wones RG, Galla JH, Rouan GW, Tsevat J, Dorfmeister JW 1999. Development and implementation of a teaching practice plan in a department of medicine (1995-1998): relative teaching units (RTU's) Trans Am Clin Climatol Assn, 110 , 214-216

Nakamura S, Amlal H, Galla J, Soleimani M 1999. NH4+ secretioni in inner medullary collecting duct in potassium deprivation: role of colonic H+-K+-ATPase Kidney Int, 56 , 2160-2167

Nakamura S,Amlal H, Schultheis P, Galla J, Shull G, Soleimani M 1999. HCO3-reabsorption in renal collecting duct of NHE-e-deficient mouse: a compensatory response Am J Physiol, 276 , F914-F921

Rouan G, Wones R, Tsevat J, Galla J, Dorfmeister J 1999. Rewarding a teaching faculty with a reimbursement plan J Gen Int Med, 14 , 327-332

Nakamura S, Amlal H, Galla J, Soleimani M. 1998. Colonic H+-K+-ATPase is induced and mediates increased HCO3 reabsorption in inner medullary collecting duct in potassium depletion Kidney Int, 54 , 1233-1239

Nakamura S, Wang Z, Galla J, Soleimani M. 1998. K+ depletion increases HCO3 reabsorption in OMCD by activation of colonic H+-K+ATPase Am J Physiol, 274 , F687-F692

Smith R, Galla J, Skahan K, Anderson P, Linnemann C, ault G, Ryschkewitsch C, Stoner G 1998. Tubulointerstitial nephritis due to a mutant polyomavirus BK strain BKV (GW) causing end-stage renal disease J Clin Microbiol, 36 , 1660-1665

Galla J, Rome L, Luke R 1995. Bicarbonate transport in collecting duct segments during chloride-depletion alkalosis Kidney Int, 48 , 52-55

Gifford JD, Ware MW, Luke RG, Galla JH 1993. HCO3 transport in rat CCD: rapid adaptation by in vivo but not in vitro alkalosis Am J Physiol, 264 , F435-F440

Gifford J, Rome L, Galla J 1992. H+-K+ -ATPase activity in rat collecting duct segments Am J Physiol, 262 , F692-F695

Jackson S, Moldoveanu Z, Kirk K, Julian B, Patterson T, Mullins A, Mestecky J, Galla J 1992. IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy Clin Exp Immunol, 89 , 315-320

Thornley-Brown D, Galla J, Williams P, Kant K, Rashkin M 1992. Lithium toxicity associated with a tricobezoar Ann Int Med, 116 , 739-740

Verlander J, Madsen K, Galla J, Luke R, Tisher C 1992. Response of intercalated cells to chloride depletion metabolic alkalosis Am J Physiol, 262 F309-F319,

Crowley-Nowick P, Julian B, Wyatt R, Galla J, Wall BM, Warnock DG, Mestecky J, Jackson S 1991. IgA nephropathy in Blacks: studies of IgA2 allotypes and clinical course Kidney Int , 39 , 1218-1224

Jackson S, Galla J, Kirk K, thorn B, Julian B 1991. Epstein-Barr virus transformation of B lymphocytes from IgA nephropathy patients and first-degree relatives results in increased immunoglobulin synthesis not restricted to IgA Am J Kidney Dis, 17 , 55-61

Sanders PW, Herrera GA, Kirk KA, Old CW, Galla JH 1991. The spectrum of glomerular and tubulointerstitial renal lesions ssociated wih monotypical immunoglobulin light chain deposition Lab Invest, 64 , 527-537

Walters E, Rome L, Luke R, Galla J. 1991. Absence of a regulatory role of angiotensin II in acute chloride-depletion alkalosis in the rat Am J Physiol, 261 , F741-745

Gifford J, Rick R, Luke R, Galla J 1990. Ion concentrations in the rat CCD: differences between cell types and effect of alkalosis Am J Physiol, 259 , F778-F782

Gifford J, Sharkins K, Work J, Luke R, Galla J 1990. Total Co2 transport in rat cortical collecting duct in chloride-depletion alkalosis Am J Physiol, 258 , F848-F853

Galla JH, Bonduris DN, Luke RG 1989. Superficial distal and deep nephrons in the correction of metabolic alkalosis Am J Physiol, 257 , F107-F113

Prchal J, Scott C, Rahbar S, Nael R, Kutlar A, Galla J and Hall K. 1989. Mild sickle cell anemia associated with alpha globin mutant, alpha Montgomery Am J Med, 86 , 232-236

Rosen RA, Julian BA, Dubovsky EV, Galla JH and Luke RG 1988. On the mechanism by which chloride corrects metabolic alkaosis in man Am J Med, 84 , 449-458

Sanders P, Herrera G, Chen A, Booker B and Galla J 1988. Differential toxicity of low molecular weight proteins including Bence Jones proteins in the profused rat nephron in vivo J Clin Invest , 82 , 2086-2096

Sanders PW, Herrera GA, Lott RL and Galla JH 1988. Morphologic alterations of the proximal tubules of patients with light chain-related renal disease Kidney Internat, 33 , 881-889

Barton J, Herrera G, Galla J, Bertoli L, Work J and Koopman W 1987. Acute cryoglobulinemic renal failure after infusion of gammaglobulin Am J Med, 82 , 624-629

Galla JH, Bonduris DN and Luke RG 1987. Effects of chloride and extracellular fluid volume on bicarbonate reabsorption along the nephron in metabolic alkalosis in the rat J Clin Invest, 80 , 41-50

Holland MD, Galla JH, Dubovsky EV and Luke RG 1987. Predictive value of beside effective renal plasma flow for renal recovery in severe acute renal failure Renal Failure, 10 , 83-89

Jackson S, Montgomery R, Julian B, Galla J and Czerkinsky C 1987. Aberrant synthesis of antibodies directed at the Fab frament of IgA in patients with IgA nephropathies Clin Immunol Immunopathol, 45 , 208-213

Julian B, Czerkinsky C, Russell M, Galla J, Koopman W, Mestecky J, Moldoveanu Z and Jackson S 1987. Striking elevation of serum IgA, Ig-containing immune complexes and IgA rheumatoid factor in clinically-silent dermatitis herpetiformis Am J Kidney Diseases, 10 , 378-384

Sanders PW, Hererra GA and Galla JH 1987. Human Bence Jones protein toxicity in rat proximal tubule epithelium in vivo Kidney Internat, 32 , 851-861

Wall BM, Byrum GV, Galla JH and Luke RG 1987. Importance of chloride for the correction of chronic metabolic alkalosis in the rat Am J Physiol, 253 , F1031-F1039

Craig DM, Galla JH, Bonduris DN and Luke RG 1986. Importance of the kidney in the correction of chloride-depletion alkalosis in the rat Am J Physiol, 250 , F54-F57

Czerkinsky C, Koopman W, Jackson S, Collins J, Crago S, Schrohenloher R, Julian B, Galla J and Mestecky J. 1986. Circulating immune complexes and IgA rheumatoid factor in patients with mesangial IgA nephropathies J Clin Invest, 77 , 1931-1938

Galla JH, Bonduris DN, Kirk KA and Luke RG 1986. Effect of dietary NaC1 on chloride uptake in the rat collecting duct segment Am J Physiol, 251 , F454-F459

Galla JH, Booker BB and Luke RG 1986. Role of the loop segment in the urinary concentrating effect of hypercalcemia Kidney Internat, 29 , 977-982

Russell M, Mestecky J, Julian B and Galla J 1986. IgA-associated renal diseases. Antibodies to environmental antigens in sera and deposition of immunoglobulins and antigens in glomeruli J Clin Immunol, 6 , 74-86

Sanders PW, Volanakis JE, Rostand SG and Galla JH 1986. Human complement proteinD catabolism by the rat kidney J Clin Invest , 77 , 1299-1304

Galla JH, Spotswood MF, Harrison LA and Mestecky J 1985. Urinary IgA in IgA nephropathy and Henoch-Schoenlien purpura J Clin Ummunol, 5 , 298-306

Holland MD, Galla JH, Sanders PW and Luke RG 1985. Effect of urinary pH and diatrizoate on Bence Jones protein nephrotoxicity in the rat Kidney Internat, 27 , 46-50

Luke RG, Booker BB and Galla JH 1985. Effect of potassium depletion on chloride transport in the loop of Henle in the rat Am J Physiol, 248 , F682-F687

Volanakis J, Barnum S, Giddens M and Galla J 1985. Renal filtration and catabolism of complement protein D N Engl J Med, 312 , 395-399

Work J, Galla J, Booker B, Schafer J and Luke R 1985. Effect of ADH on chloride reabsorption in the loop of Henle of the Brattleboro rat Am J Physiol, 249 , F698-F703

Galla J, Kohaut E, Alexander R and Mestecky J 1984. Racial difference in the prevalence of IgA-associated nephropathies Lancet, 2 , 522

Galla JH, Bonduris DN, Dumbauld SL and Luke RG 1984. Segmental chloride and fluid handling during correction of chloride-depletion alkalosis without volume expansion in the rat J Clin Invest, 73 , 96-106

Galla JH, Bondurs DN, SAnders PW and Luke RG 1984. Volume-independent reductions in glomerular filtration rate in acute chloride-depletion alkalosis in the rat J Clin Invest, 74 , 2002-2008

Wyatt RJ, Julian BA, Galla JH and McLean RH 1984. Increased frequency of C3 fast alleles in IgA nephropathy Disease Markers, 2 , 419-428

Dekich SE, Galla JH and Pacifico AD 1983. Proteinuria and hemoglobinuria: A diagnostic problem N Engl J Med, 309 , 857 & 1532

Galla JH, Bonduris DN and Luke RG 1983. Correction of acute chloride-depletion alkalosis in the rat without volume expansion Am J Physiol, 244 , F217-F221

Julian BA, Wyatt RJ, McMorrow RG and Galla JH 1983. Serum complement proteins in IgA nephropathy Clin Nephrol, 20 , 251-258

Kotchen TA, Guthrie GP Jr, Galla JH, Luke RG and Welch WJ 1983. Effect of NaC1 on the renin and aldosterone responses to potassium depletion Am J Physiol, 244 , E164-E169

Kotchen TA, Luke RG, Ott CB, Galla JH and Whitescarver S 1983. Effect of chloride on renin and blood pressue responses to sodium chloride Ann Int Med, 98 , 817-822

Curtis JJ, Galla JH, Woodford SY, Lucas BA and Luke RG 1982. Effect of alternate-day prednisone on plasma lipids in renal transplant recipients Kidney Internat, 22 , 42-47

Galla JH and Luke RG 1982. Influence of aortic constriction on proximal chloride reabsorption during volume expansion Mineral Elect Metab, 8 , 13-20

Julian BA, Galla JH, Guthrie GP Jr. and Kotchen TA 1982. Renin and aldosterone responses to short-term NaC1 or NaHCO3 loading in man J Lab Clin Med, 100 , 261-268

Luke R, Lyerly R, Anderson J, Galla J and Kotchen T 1982. Effect of potassium depletion on renin release Kidney Internat, 21 , 14-19

McMorrow RG, Galla JH and Luke RG 1982. Quantitative urinary protein excretion in chronic renal failure Am J Nephrol, 2 , 208-212

Abboud HE, Galla JH, Lucas BA, Curis JJ and Luke RG 1981. Acute renal failure due to seminoma metastatic to the kidneys Nephron, 27 , 101-103

Curtis JJ, Galla JH, Woodford SY, Saykaly RJ and Luke RG 1981. Comparison of daily and alternate-day prednisone during chronic maintenance therapy: A controlled crossover study Am J Kidney, 1 , 166-171

Galla JH, Kirchner KA, Kotchen TA and Luke RG 1981. Effect of hypochloremia on loop segment chloride and solute reabsorption in the rat during volume expansion Kidney Internat, 20 , 569-574

Weiss JH, Williams RH, Galla JH, Gottschall JL, Rees ED, Bhathena D and Luke RG 1981. Pathophysiology of acute Bence Jones protein nephrotoxicity in the rat Kidney Internat, 20 , 198-210

Wyatt RJ, Julian BA and Galla JH 1981. Properdin deficiency in IgA nephropathy N Engl J Med, 305 , 1097

Galla JH, Curtis JJ, Woodford SY, Rees ED, Somes GW and Luke RG 1980. Effect of prednisone dose spacing on plasma lipids J Lab Clin Med, 95 , 801-807

Kirchner KA, Galla JH and Luke RG 1980. Factors influencing chloride reabsorption in the collecting duct segment in the rat Am J Physiol , 239 , F552-F559

Kotchen TA, Krzyzaniak KE, Anderson JE, Ernst CB, Galla JH and Luke RG 1980. Inhibition of renin secretion by HCI is related to chloride in both dog and rat Am J Physiol, 239 , F44-F49

Talwalker RT, Kotchen TA, Welch WJ, Curtis JJ and Galla JH 1980. Different mechanisms for the increased enzymatic acivity of renin in plasma of patients with chronic renal failure and patients receiving glucocorticoid therapy J Clin Endocrinol Metab, 50 , 989-993

Abboud HE, Luke RG, Galla JH and Kotchen TA 1979. Stimulation of renin by acute selective chloride depletion in the rat Circ Res, 44 , 815-821

Galla JH and Luke RG 1979. Volume expansion-induced alterations in proximal tubule chloride gradient in the rat Am J Physiol, 237 , F473-478

Kirchner KA, Galla JH, Curtis JJ and Luke RG 1979. Hemodialysis and kidney transplantation in a patient with glucose phosphate isomerase deficiency Transplantation, 28 , 316-317

Curt JJ, Galla JH, Woodford SY, Rees ED and Luke RG 1978. Effect of renal transplantation on hyperlipidemia and high-density lipoprotein cholesterol (HDL) Transplantation, 26 , 364-366

Dominic J, Koch M, Guthrie G and Galla J 1978. Primary aldosteronism presenting as myoglobinuric acute renal failure Arch Int Med, 138 , 1433-1434

Galla J and Bhathena D 1978. Malacoplakia of the kidney: apparent improvement following medical management Clin Nephrol, 9 , 35-37

Galla JH, Beaumont JE, Curtis JJ, Rees ED and Luke RG 1978. Alternate-day corticosteroid effect on lipid metabolisum J Lab Clin Med, 91 , 123-126

Kirchner KA, Kotchen TA, Galla JH and Luke RG 1978. Importance of chloride for acute inhibition of renin by sodium chloride Am J Physiol, 235 , F444-F450

Kotchen TA, Galla JH and Luke RG 1978. Contribution of chloride to the inhibition of plasma renin by sodium chloride in the rat Kidney Internat, 13 , 201-207

Baehler R, Kotchen T, Burke J, Galla J and Bhathena D 1977. Considerations on the pathophysiology of mercuric chloride-induced acute renal failure Journal of Laboratory and Clinical Medicine, 90 , 330-340

Beaumont JE, Kotchen TA, Galla JH and Luke RG 1977. Failure of loading with sodium bicarbonate to protect against acute renal failure induced by mercuric chloride in the rat Clinical Journal of Scientific Molecular Medicine, 55 , 149-154

Galla JH, Beaumont JE and Luke RG 1977. Effect of volume expansion with NaCI or NaHCO3 on nephron fluid and C1 transport American Journal of Physiology, 233 , F118-F125

Galla JH, Kotchen TA and Luke RG 1977. Failure of sodium iodide loading to inhibit renin in the rat Proceedings of the Society for Experimental Biology and Medicine, 154 , 30-32

Galla JH, Schneider G, Kotchen TA and Hayslett P 1977. Renin and aldosterone in the cardiomyopathic hamster in congestive heart failure Endocrinology, 101 , 389-395

Kotchen TA, Galla JH and Luke RG 1977. Effects of calcium on renin and aldosterone in the rat American Journal of Physiology, 232 , E388-E393

Luke RG, Khanh BT, Schmidt RD and Galla JH 1977. Natriuresis in rats acutely depleted of chloride Clinical Science of Molecular Medicine, 52 , 23-31

Curtis J, Bhathena D, Leach R, Galla J, Lucas B and Luke R 1976. Goodpasture's syndrome in a patient with the nail-patella syndrome American Journal of Medicine, 61 , 401-406

Curtis J, Galla J, Kotchen T, Lucas B, McRoberts J and Luke R 1976. Prevalence of hypertension in a renal transplant population on alternate-day steroid therapy Clinical Nephrology, 5 , 123-127

Kotchen TA, Galla JH and Luke RG 1976. Failure of NaHCO3 and KHCO3 to inhibit renin in the rat American Journal of Physiology, 231 , 1050-1056

Beaumont JE, Galla JH, Luke RG, Rees ED and Siegel RR 1975. Normal serum lipids in renal-transplant patients Lancet, 1 , 599-605

Galla J, Forrest J, Hecht B, Kashgarian M and Hayslett J 1975. Effect of lithium on water and electrolyte metabolism Yale Journal of Biology and Medicine, 48 , 305-314

Bullock JD, Albert DM, Skinner CW, Miller WH and Galla JH 1974. Calcium oxalate retinopathy associated with generalized oxalosis: X-ray diffraction and electron microscopic studies of crystal deposits Investigative Ophthalmology, 13 , 256-265

Galla JH, Klein-Robbenhaar T and Hayslett JP 1974. Influence of age on the compensatory response in growth and function to unilateral nephrectomy Yale Journal of Biology and Medicine, 47 , 218-226

Brenner BM and Galla JH 1971. Influence of postglomerular hematocrit and protein concentration on rat nephron fluid transfer American Journal of Physiology, 220 , 148-161

Published Abstracts

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Galla JH, Bhat G, Mangu P, Clemens TL, First MR 1999. Novel syndrome of heritable hypercalciuria and nephrocalcinosis , ,


Nakamura S, Spicer Z, Amlal H, Shull GE, Galla JH, Soleimani M 1999. Renal NH4+ Secretion in Colonic H+-K+-ATPase (HKAc) Deficient Mouse: Effect of K+ Deprivation , ,


Nakamura S, Wang Z, Soleimani M, Galla J 1998. Colonic H-K-ATPase (cHKA) mediates ouabain-sensitive HCO3- reabsorption outer medullary collecting duct (OMCD) in rats with chloride-depletion alkalosis (CDA) , ,


Nakamura S, Wang Z, Soleimani M, Galla JH 1998. Colonic H-K-ATPase (cHKA) mediates ouabain-sensitive HCO3- reabsorption in outer medullary collecting duct (OMCD) in rats with chloride-depletion alkalosis (CDA) , ,


Sanders PW, Herrera GA, Galla JH 1998. Transcytosis and transtubular movement of human immunoglobulin light chains in the proximal tubule of the rat in vivo , ,


Roy-Chaudhury P, Heffelfinger SC, Miller MA, Denman D, Munda R, First MR, Galla JH, Whiting J 1997. An immunohistological analysis of venous stenosis in PTFE dialysis grafts , ,


Wang Z, Silver R, Frindt G, Galla J, Soleimani M 1997. Renal colonic H+-K+-ATPase (cHKA) upregulation in Na depletion or hypotonicity: possible roles in acid-base homeostasis , ,


Duncan J, Galla JH 1996. Changes in chemosensory dysfunction in dialysis patients and their relationship to malnutrition , ,


Duncan H, Frank R, Kues J, Johnson L, Warshaw GA, Heacock P, Heile S, Nortol P, Galla JH 1995. Chemosensory complaints and their relationships to malnutrition in ESRD patients , ,


Galla JH, Duncan H 1995. Mortality in dialysis patients with chemosensory disorders and malnutrition , ,


Duncan H, Kues J, Heacock P, Heile S, Norton P, Johnson L, Galla JH 1994. Malnutrition in hemodialysis patients correlates with chemosensory disorders , ,


Galla JH, Cuppoletti J, Rome L 1994. Chloride-depletion alkalosis (CDA) inhibits net HCO3 transport and activates H+K+ATPase in terminal inner medullary collecting duct (IMCDt) , ,


Galla JH, Cuppoletti J, Rome L 1994. Chloride-depletion alkalosis (CDA) inhibits net HCO3 transport and activates H+K+ATPase in terminal inner medullary collecting duct (IMCDt). , ,


Duncan H, Kues J, Frank R, Heacock P, Heile S, Norton P, Johnson L, Galla JH 1993. Chemosensory disorders in hemodialysis patients as assessed by interview , ,


Rome L, Gifford JD, Galla JH 1992. HCO3 transport in terminal inner medullary collecting duct (IMCDt) by acute chloride-depletion alkalosis (CDA) , ,


Wall BM, King G, Phillips N, Bobal MA, Galla JH, Luke RG 1992. Chloride decreases net acid excretion and corrects chronic chloride-depletion alkalosis in the absence of Na and K intake , ,


Gifford JD, Ware M, Shull GE, Luke RG, Burnham C, Galla JH 1991. Effect of acid-base disorders on expression of rat kidney band 3 (AE-1) mRN , ,


Verlander JW, Madsen KM, Galla JH, Luke RG, Tisher CC 1991. Effect of chloride infusion on the respone of itnercalated cells (IC) to chloride depletion metabolic alkalosis , ,


Galla JH, Booker BB, Work J, Luke RG 1988. Aldosterone alters NaCl reabsorption in the loop segment during changes in dietary NaCl intake , ,


Booker BB, Galla JH, Luke RG 1987. Indomethacin interferes with the inhibitory effect of luminal furosemide on chloride absorption in the thick ascending limb , ,


Julian BA, Waldo FB, Wyatt R, Galla J, Kohaut EC 1987. Relationship between age and disease profnosis in IgA nephropathy , ,


Galla JH, Booker BB, Luke RG 1986. Dietary NaCl intake alters chloride reabsorption in the loop segment of superficial nephrons , ,


Galla JH, Booker BB, Work J, Luke RG 1986. Effects of hyperkalemia with and without hyperchloremia on superficial loop of Henle function in the rat , ,


Luke RG, Booker BB, Galla JH 1986. Relationship between furosemide and prostaglandin inhibitionin the loop segment , ,


Wall BM, Galla JH, Luke RG 1986. The role of aldosterone in the maintenance of chronic metabolic alkalosis in the rat , ,


Booker BB, Galla JH, Luke RG 1985. Dietary sodium chloride intake alters chloride reabsorption in the loop segment of superficial nephrons (LS) , ,


Galla JH, Booker BB, Luke RG 1985. Chronic dietary sodium chloride loading alters chloride reabsorption in the loop segment of superficial nephrons , ,


Work J, Booker BB, Galls JH, Luke RG 1985. Acute KCl loading increases superficial loop of Henle chloride reabsorption , ,


Luke RG, Booker BB, Galla JH 1984. Prostaglandin inhibits ADH-stimulated loop chloride absorption in the rat in vivo , ,


Dumbauld SL, Galla JH and Luke RG 1982. Micropuncture study of chronic selective mineralcorticoid deficiency in the rat. Clin Res, 30 , 785A