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Photo of  Yuhang Zhang, PHD

Yuhang Zhang, PHD


  • Ph.D: South China University of Technology (Biotechnology)
Contact Information
Research Interests

The Mesenchymal Compartment, Epithelial-Mesenchymal Interaction and Hair Follicle Biology
Reversing hair loss disorders and creating relatively normal skin replacement after injury have long been major clinical challenges to dermatologists and surgeons. A stumbling block is the lack of an effective means to regulate epithelial-mesenchymal interactions (EMIs) between epidermal keratinocytes and dermal fibroblasts, which is necessary to control stem cell activation and ...

Peer Reviewed Publications

Xiao, Yao; Zhou, Linli; Andl, Thomas; Zhang, Yuhang 2024. YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression. Oncogene, ,

Andl, Thomas; Zhou, Linli; Zhang, Yuhang 2023. The dermal papilla dilemma and potential breakthroughs in bioengineering hair follicles. Cell and tissue research, 391 2, 221-233

Zhou, Linli; Ji, Wei; Dicolandrea, Teresa; Finlay, Deborah; Supp, Dorothy; Boyce, Steven; Wei, Karl; Kadekaro, Ana Luisa; Zhang, Yuhang 2023. An improved human skin explant culture method for testing and assessing personal care products. Journal of cosmetic dermatology, 22 5, 1585-1594

Liu, Tianyi; Zhou, Linli; Xiao, Yao; Andl, Thomas; Zhang, Yuhang 2022. BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma. Cancer research, 82 3, 419-432

Dunaway, Spencer; Rothaus, Alexandra; Zhang, Yuhang; Luisa Kadekaro, Ana; Andl, Thomas; Andl, Claudia D 2019. Divide and conquer: two stem cell populations in squamous epithelia, reserves and the active duty forces. International journal of oral science, 11 3, 26

Liu, Tianyi; Zhou, Linli; Li, Danni; Andl, Thomas; Zhang, Yuhang 2019. Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment. Frontiers in cell and developmental biology, 7 , 60

Liu, Tianyi; Zhou, Linli; Yang, Kun; Iwasawa, Kentaro; Kadekaro, Ana Luisa; Takebe, Takanori; Andl, Thomas; Zhang, Yuhang 2019. The ?-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal transduction and targeted therapy, 4 , 63

Andl, Thomas; Andl, Claudia D; Zhang, Yuhang 2018. Two-edged sword: how activation of the "proto-oncogene" yes-associated protein 1 in lung squamous cell carcinoma can surprisingly inhibit tumor growth. Journal of thoracic disease, 10 Suppl 33, S3870-S3874

Dunaway, Spencer; Odin, Rachel; Zhou, Linli; Ji, Liyuan; Zhang, Yuhang; Kadekaro, Ana L 2018. Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation. Frontiers in pharmacology, 9 , 392

Song, Yaolin; Boncompagni, Ana C; Kim, Sang-Seok; Gochnauer, Heather R; Zhang, Yuhang; Loots, Gabriela G; Wu, Dianqing; Li, Yulin; Xu, Mingang; Millar, Sarah E 2018. Regional Control of Hairless versus Hair-Bearing Skin by Dkk2. Cell reports, 25 11, 2981-2991.e3

Andl, Thomas; Zhang, Yuhang 2017. Reaping Wnt after calming Hippo: Wnt and Hippo signaling cross paths in lung cancer. Journal of thoracic disease, 9 11, 4174-4179

Andl, Thomas; Zhou, Linli; Yang, Kun; Kadekaro, Ana Luisa; Zhang, Yuhang 2017. YAP and WWTR1: New targets for skin cancer treatment. Cancer letters, ,

Zhou, Linli; Yang, Kun; Dunaway, Spencer; Abdel-Malek, Zalfa; Andl, Thomas; Kadekaro, Ana Luisa; Zhang, Yuhang 2017. Suppression of MAPK signaling in BRAF-activated PTEN-deficient melanoma by blocking ?-catenin signaling in cancer-associated fibroblasts. Pigment cell & melanoma research, ,

Andl, Claudia D; Le Bras, Grégoire F; Loomans, Holli; Kim, Annette S; Zhou, Linli; Zhang, Yuhang; Andl, Thomas 2016. Association of TGF-beta signaling with the maintenance of a quiescent stem cell niche in human oral mucosa. Histochemistry and cell biology, 146 5, 539-555

Zhou, Linli; Xu, Mingang; Yang, Yongguang; Yang, Kun; Wickett, Randall R; Andl, Thomas; Millar, Sarah E; Zhang, Yuhang 2016. Activation of beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth. PloS one, 11 7, e0160425

Zhou, Linli; Yang, Kun; Carpenter, April; Lang, Richard A; Andl, Thomas; Zhang, Yuhang 2016. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth. The Biochemical journal, 473 19, 3291-305

Zhou, Linli; Yang, Kun; Randall Wickett, R; Zhang, Yuhang 2016. Dermal fibroblasts induce cell cycle arrest and block epithelial-mesenchymal transition to inhibit the early stage melanoma development. Cancer medicine, 5 7, 1566-79

Zhou, Linli; Yang, Kun; Wickett, R Randall; Kadekaro, Ana Luisa; Zhang, Yuhang 2016. Targeted deactivation of cancer-associated fibroblasts by beta-catenin ablation suppresses melanoma growth. Tumour biology, 37 10, 14235-14248

Zhou, Linli; Yang, Kun; Wickett, Randall R; Andl, Thomas; Zhang, Yuhang 2016. Dermal sheath cells contribute to postnatal hair follicle growth and cycling. Journal of dermatological science, 82 2, 129-31

Zhou, Linli; Yang, Kun; Xu, Mingang; Andl, Thomas; Millar, Sarah E; Boyce, Steven; Zhang, Yuhang 2016. Activating beta-catenin signaling in CD133-positive dermal papilla cells increases hair inductivity. The FEBS journal, 283 15, 2823-35

Zhou, Linli; Yang, Kun; Andl, Thomas; Wickett, R Randall; Zhang, Yuhang 2015. Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma. Journal of Cancer, 6 8, 717-26

Choi, Yeon Sook; Zhang, Yuhang; Xu, Mingang; Yang, Yongguang; Ito, Mayumi; Peng, Tien; Cui, Zheng; Nagy, Andras; Hadjantonakis, Anna-Katerina; Lang, Richard A; Cotsarelis, George; Andl, Thomas; Morrisey, Edward E; Millar, Sarah E 2013. Distinct functions for Wnt/beta-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell stem cell, 13 6, 720-33

Liu F, Dangaria S, Andl T, Zhang Y, Wright AC, Damek-Poprawa M, Piccolo S, Nagy A, Taketo MM, Diekwisch TG, Akintoye SO, Millar SE. 2010. beta-Catenin initiates tooth neogenesis in adult rodent incisors Journal of Dental Research, 89 9, 904

Zhang, Yuhang; Tomann, Philip; Andl, Thomas; Gallant, Natalie M; Huelsken, Joerg; Jerchow, Boris; Birchmeier, Walter; Paus, Ralf; Piccolo, Stefano; Mikkola, Marja L; Morrisey, Edward E; Overbeek, Paul A; Scheidereit, Claus; Millar, Sarah E; Schmidt-Ullrich, Ruth 2009. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Developmental cell, 17 1, 49-61

Liu, Fei; Chu, Emily Y; Watt, Brenda; Zhang, Yuhang; Gallant, Natalie M; Andl, Thomas; Yang, Steven H; Lu, Min-Min; Piccolo, Stefano; Schmidt-Ullrich, Ruth; Taketo, Makoto M; Morrisey, Edward E; Atit, Radhika; Dlugosz, Andrzej A; Millar, Sarah E 2008. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Developmental biology, 313 1, 210-24

Zhang, Yuhang; Andl, Thomas; Yang, Steven H; Teta, Monica; Liu, Fei; Seykora, John T; Tobias, John W; Piccolo, Stefano; Schmidt-Ullrich, Ruth; Nagy, Andras; Taketo, Makoto M; Dlugosz, Andrzej A; Millar, Sarah E 2008. Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (Cambridge, England), 135 12, 2161-72

Andl, Thomas; Murchison, Elizabeth P; Liu, Fei; Zhang, Yuhang; Yunta-Gonzalez, Monica; Tobias, John W; Andl, Claudia D; Seykora, John T; Hannon, Gregory J; Millar, Sarah E 2006. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Current biology : CB, 16 10, 1041-9

Zhang, Yuhang*; Imtiyaz, Hongxia Z*; Rosenberg, Stephen*; Rahman, Ziaur S M; Hou, Ying-Ju; Manser, Tim; Zhang, Jianke 2006. The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. Journal of immunology (Baltimore, Md. : 1950), 176 11, 6852-61

Imtiyaz, Hongxia Z; Zhang, Yuhang; Zhang, Jianke 2005. Structural requirements for signal-induced target binding of FADD determined by functional reconstitution of FADD deficiency. The Journal of biological chemistry, 280 36, 31360-7

Zhang, Yuhang; Rosenberg, Stephen; Wang, Hanming; Imtiyaz, Hongxia Z; Hou, Ying-Ju; Zhang, Jianke 2005. Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 175 5, 3033-44