Education/CredentialsResidency: Washington University-Barnes/Jewish Hospital (Anatomic Pathology )Clinical Trainee: Washington UniversityMedical Degree: University of Cincinnati College of MedicineDoctorate: Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine (Developmental Biology) Contact Information Email wikenhka@ucmail.uc.edu Research InterestsPulmonary pathology, lung development, lung cancer Peer Reviewed Publications Bedard, Mary C; Brusadelli, Marion G; Carlile, Adrean; Ruiz-Torres, Sonya; Lodin, Hannah; Lee, Denis; Kofron, Matthew; Lambert, Paul F; Lane, Adam; Ameziane, Najim; Bahassi, El Mustapha; Wikenheiser-Brokamp, Kathryn A; de Alarcon, Alessandro; Smith, David F; Wells, Susanne I 2021. Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. Viruses, 13 1, Bedard, Mary C; de Alarcon, Alessandro; Kou, Yann-Fuu; Lee, David; Sestito, Alexandra; Duggins, Angela L; Brusadelli, Marion; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I; Smith, David F 2021. HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening. Cancers, 13 11, Benzaquen, Sadia; Kaini, Navin; Gupta, Ena; Litwin, Dianne; Wikenheiser-Brokamp, Kathryn A; Aragaki-Nakahodo, Alejandro 2021. Women Presenting With Asthma and Persistent Wheezing: A Case Series. Chest, 159 4, e267-e275Gao, Denny K; Salomonis, Nathan; Henderlight, Maggie; Woods, Christopher; Thakkar, Kairavee; Grom, Alexei A; Thornton, Sherry; Jordan, Michael B; Wikenheiser-Brokamp, Kathryn A; Schulert, Grant S 2021. IFN-? is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI insight, 6 17, Hawkins, Padraig; Chawke, Liam; Cormican, Liam; Wikenheiser-Brokamp, Kathryn A; Fabre, Aurelie; Keane, Michael P; McCarthy, Cormac 2021. Autoimmune pulmonary alveolar proteinosis: a discrepancy between symptoms and CT findings. Lancet (London, England), 398 10296, e7Hayes, Don; Darland, Leanna K; Hjelm, Michelle A; Mansour, Heidi M; Wikenheiser-Brokamp, Kathryn A 2021. To treat or not to treat: CFTR modulators after lung transplantation. Pediatric transplantation, 25 4, e14007Ogden, Herbert Luke; Kim, Hoyeol; Wikenheiser-Brokamp, Kathryn A; Naren, Anjaparavanda P; Mun, Kyu Shik 2021. Cystic Fibrosis Human Organs-on-a-Chip. Micromachines, 12 7, Pearson, Joel D; Huang, Katherine; Pacal, Marek; McCurdy, Sean R; Lu, Suying; Aubry, Arthur; Yu, Tao; Wadosky, Kristine M; Zhang, Letian; Wang, Tao; Gregorieff, Alex; Ahmad, Mohammad; Dimaras, Helen; Langille, Ellen; Cole, Susan P C; Monnier, Philippe P; Lok, Benjamin H; Tsao, Ming-Sound; Akeno, Nagako; Schramek, Daniel; Wikenheiser-Brokamp, Kathryn A; Knudsen, Erik S; Witkiewicz, Agnieszka K; Wrana, Jeffrey L; Goodrich, David W; Bremner, Rod 2021. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer cell, 39 8, 1115-1134.e12Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Ruiz-Torres, Sonya; Lambert, Paul F; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2021. Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. Molecular biology reports, 48 8, 6213-6222Guo, Minzhe; Yu, Jane J; Perl, Anne Karina; Wikenheiser-Brokamp, Kathryn A; Riccetti, Matt; Zhang, Erik Y; Sudha, Parvathi; Adam, Mike; Potter, Andrew; Kopras, Elizabeth J; Giannikou, Krinio; Potter, S Steven; Sherman, Sue; Hammes, Stephen R; Kwiatkowski, David J; Whitsett, Jeffrey A; McCormack, Francis X; Xu, Yan 2020. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American journal of respiratory and critical care medicine, 202 10, 1373-1387Kosciuk, Patrick; Meyer, Cristopher; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2020. Pulmonary alveolar microlithiasis. European respiratory review : an official journal of the European Respiratory Society, 29 158, Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T 2020. MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI insight, 5 4, Obaidat, Baha; Yazdani, Dina; Wikenheiser-Brokamp, Kathryn A; Gupta, Nishant 2020. Diffuse Cystic Lung Diseases. Respiratory care, 65 1, 111-126Oltvai, Zoltán N; Smith, Eric A; Wiens, Katie; Nogee, Lawrence M; Luquette, Mark; Nelson, Andrew C; Wikenheiser-Brokamp, Kathryn A 2020. Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter. Cold Spring Harbor molecular case studies, 6 3, Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Suzuki, Takuji; McCarthy, Cormac; Carey, Brenna C; Borchers, Michael; Beck, David; Wikenheiser-Brokamp, Kathryn A; Black, Dianna; Chalk, Claudia; Trapnell, Bruce C 2020. Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis. American journal of respiratory cell and molecular biology, 62 1, 87-94Schulert, Grant S; Yasin, Shima; Carey, Brenna; Chalk, Claudia; Do, Thuy; Schapiro, Andrew H; Husami, Ammar; Watts, Allen; Brunner, Hermine I; Huggins, Jennifer; Mellins, Elizabeth D; Morgan, Esi M; Ting, Tracy; Trapnell, Bruce C; Wikenheiser-Brokamp, Kathryn A; Towe, Christopher; Grom, Alexei A 2019. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis & rheumatology (Hoboken, N.J.), 71 11, 1943-1954Suhrie, Kristen; Pajor, Nathan M; Ahlfeld, Shawn K; Dawson, D Brian; Dufendach, Kevin R; Kitzmiller, Joseph A; Leino, Daniel; Lombardo, Rachel C; Smolarek, Teresa A; Rathbun, Pamela A; Whitsett, Jeffrey A; Towe, Christopher; Wikenheiser-Brokamp, Kathryn A 2019. Neonatal Lung Disease Associated with TBX4 Mutations. The Journal of pediatrics, 206 , 286-292.e1Taylor, Deanne M; Aronow, Bruce J; Tan, Kai; Bernt, Kathrin; Salomonis, Nathan; Greene, Casey S; Frolova, Alina; Henrickson, Sarah E; Wells, Andrew; Pei, Liming; Jaiswal, Jyoti K; Whitsett, Jeffrey; Hamilton, Kathryn E; MacParland, Sonya A; Kelsen, Judith; Heuckeroth, Robert O; Potter, S Steven; Vella, Laura A; Terry, Natalie A; Ghanem, Louis R; Kennedy, Benjamin C; Helbig, Ingo; Sullivan, Kathleen E; Castelo-Soccio, Leslie; Kreigstein, Arnold; Herse, Florian; Nawijn, Martijn C; Koppelman, Gerard H; Haendel, Melissa; Harris, Nomi L; Rokita, Jo Lynne; Zhang, Yuanchao; Regev, Aviv; Rozenblatt-Rosen, Orit; Rood, Jennifer E; Tickle, Timothy L; Vento-Tormo, Roser; Alimohamed, Saif; Lek, Monkol; Mar, Jessica C; Loomes, Kathleen M; Barrett, David M; Uapinyoying, Prech; Beggs, Alan H; Agrawal, Pankaj B; Chen, Yi-Wen; Muir, Amanda B; Garmire, Lana X; Snapper, Scott B; Nazarian, Javad; Seeholzer, Steven H; Fazelinia, Hossein; Singh, Larry N; Faryabi, Robert B; Raman, Pichai; Dawany, Noor; Xie, Hongbo Michael; Devkota, Batsal; Diskin, Sharon J; Anderson, Stewart A; Rappaport, Eric F; Peranteau, William; Wikenheiser-Brokamp, Kathryn A; Teichmann, Sarah; Wallace, Douglas; Peng, Tao; Ding, Yang-Yang; Kim, Man S; Xing, Yi; Kong, Sek Won; Bönnemann, Carsten G; Mandl, Kenneth D; White, Peter S 2019. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental cell, 49 1, 10-29Wang, Yuhua; Pandey, Ram Naresh; York, Allen J; Mallela, Jaya; Nichols, William C; Hu, Yueh-Chiang; Molkentin, Jeffery D; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2019. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature communications, 10 1, 4143Gupta, Nishant; Colby, Thomas V; Meyer, Cristopher A; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn A 2018. Smoking-Related Diffuse Cystic Lung Disease. Chest, 154 2, e31-e35Matrka, Marie C; Cimperman, Katherine A; Haas, Sarah R; Guasch, Geraldine; Ehrman, Lisa A; Waclaw, Ronald R; Komurov, Kakajan; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2018. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS genetics, 14 3, e1007227Wang, Yuhua; Pandey, Ram Naresh; Riffle, Stephen; Chintala, Hemabindu; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2018. The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular cancer therapeutics, 17 8, 1659-1669Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A 2018. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 121 2, 179-185Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A 2017. Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response. Molecular cancer therapeutics, , Gupta, N; Wikenheiser-Brokamp, K; Zander, D; Balestra, R; Selvaraju, A; Niehaus, K; Benzaquen, S 2017. Successful diagnosis of lymphangioleiomyomatosis with transbronchial lung cryobiopsy. Lymphology, 50 3, 154-157Gupta, Nishant; Finlay, Geraldine A; Kotloff, Robert M; Strange, Charlie; Wilson, Kevin C; Young, Lisa R; Taveira-DaSilva, Angelo M; Johnson, Simon R; Cottin, Vincent; Sahn, Steven A; Ryu, Jay H; Seyama, Kuniaki; Inoue, Yoshikazu; Downey, Gregory P; Han, MeiLan K; Colby, Thomas V; Wikenheiser-Brokamp, Kathryn A; Meyer, Cristopher A; Smith, Karen; Moss, Joel; McCormack, Francis X 2017. Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline. American journal of respiratory and critical care medicine, 196 10, 1337-1348Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 10, 1318-1330Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A 2017. p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis, 6 4, e320Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia 2017. A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique. Journal of bronchology & interventional pulmonology, 24 2, 131-135Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K 2017. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of pediatrics, 181 , 5-6.e3Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2016. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem cell reports, 6 1, 44-54Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X 2016. Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome. Annals of the American Thoracic Society, 13 3, 371-5McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel 2016. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American journal of respiratory and critical care medicine, 194 6, 748-61Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T 2016. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI insight, 1 16, e87270Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A 2016. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI insight, 1 20, e90558Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A 2015. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene, 34 5, 589-99Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part II. American journal of respiratory and critical care medicine, 192 1, 17-29Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part I. American journal of respiratory and critical care medicine, 191 12, 1354-66Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G 2015. Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships. The Journal of pediatrics, 167 3, 506-7.e1Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I 2015. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 8, 1962-72Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 313, 313ra181Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A 2015. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. The Journal of pathology, 236 1, 41-52Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2014. High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells. Journal of virology, 88 19, 11315-26Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia 2014. Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis. American journal of respiratory and critical care medicine, 189 4, 490-1Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan 2014. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International journal of oncology, 45 3, 978-84McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine 2014. TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development (Cambridge, England), 141 23, 4628-39Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A 2013. Mucoepidermoid carcinoma of the lung: a case report and literature review. Case reports in oncological medicine, 2013 , 625243McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn 2013. An atoll variant that mocks. American journal of respiratory and critical care medicine, 188 1, 110Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M 2013. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 9, 1167-70Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J 2012. Occam's razor or Hickam's dictum? Journal of bronchology & interventional pulmonology, 19 3, 216-9Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The fanconi anemia pathway limits human papillomavirus replication. Journal of virology, 86 15, 8131-8Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X 2012. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Frontiers of medicine, 6 4, 395-405Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X 2012. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Seminars in respiratory and critical care medicine, 33 5, 486-97Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W 2011. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases Chest, 139 2, 353-60Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan 2011. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC cancer, 11 , 513Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer Oncogene, , Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J 2009. DICER1 mutations in familial pleuropulmonary blastoma Science (New York, N.Y.), 325 5943, 965Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis Cancer research, 69 22, 8733-41Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program The American journal of pathology, 174 1, 71-81Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. 2009. Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, 136 3, 962-933Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E 2007. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocrine-related cancer, 14 2, 445-52Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S 2007. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology, 133 3, 976-84Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley . Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 18 6, 504-11
Peer Reviewed Publications Bedard, Mary C; Brusadelli, Marion G; Carlile, Adrean; Ruiz-Torres, Sonya; Lodin, Hannah; Lee, Denis; Kofron, Matthew; Lambert, Paul F; Lane, Adam; Ameziane, Najim; Bahassi, El Mustapha; Wikenheiser-Brokamp, Kathryn A; de Alarcon, Alessandro; Smith, David F; Wells, Susanne I 2021. Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. Viruses, 13 1, Bedard, Mary C; de Alarcon, Alessandro; Kou, Yann-Fuu; Lee, David; Sestito, Alexandra; Duggins, Angela L; Brusadelli, Marion; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I; Smith, David F 2021. HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening. Cancers, 13 11, Benzaquen, Sadia; Kaini, Navin; Gupta, Ena; Litwin, Dianne; Wikenheiser-Brokamp, Kathryn A; Aragaki-Nakahodo, Alejandro 2021. Women Presenting With Asthma and Persistent Wheezing: A Case Series. Chest, 159 4, e267-e275Gao, Denny K; Salomonis, Nathan; Henderlight, Maggie; Woods, Christopher; Thakkar, Kairavee; Grom, Alexei A; Thornton, Sherry; Jordan, Michael B; Wikenheiser-Brokamp, Kathryn A; Schulert, Grant S 2021. IFN-? is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI insight, 6 17, Hawkins, Padraig; Chawke, Liam; Cormican, Liam; Wikenheiser-Brokamp, Kathryn A; Fabre, Aurelie; Keane, Michael P; McCarthy, Cormac 2021. Autoimmune pulmonary alveolar proteinosis: a discrepancy between symptoms and CT findings. Lancet (London, England), 398 10296, e7Hayes, Don; Darland, Leanna K; Hjelm, Michelle A; Mansour, Heidi M; Wikenheiser-Brokamp, Kathryn A 2021. To treat or not to treat: CFTR modulators after lung transplantation. Pediatric transplantation, 25 4, e14007Ogden, Herbert Luke; Kim, Hoyeol; Wikenheiser-Brokamp, Kathryn A; Naren, Anjaparavanda P; Mun, Kyu Shik 2021. Cystic Fibrosis Human Organs-on-a-Chip. Micromachines, 12 7, Pearson, Joel D; Huang, Katherine; Pacal, Marek; McCurdy, Sean R; Lu, Suying; Aubry, Arthur; Yu, Tao; Wadosky, Kristine M; Zhang, Letian; Wang, Tao; Gregorieff, Alex; Ahmad, Mohammad; Dimaras, Helen; Langille, Ellen; Cole, Susan P C; Monnier, Philippe P; Lok, Benjamin H; Tsao, Ming-Sound; Akeno, Nagako; Schramek, Daniel; Wikenheiser-Brokamp, Kathryn A; Knudsen, Erik S; Witkiewicz, Agnieszka K; Wrana, Jeffrey L; Goodrich, David W; Bremner, Rod 2021. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer cell, 39 8, 1115-1134.e12Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Ruiz-Torres, Sonya; Lambert, Paul F; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2021. Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. Molecular biology reports, 48 8, 6213-6222Guo, Minzhe; Yu, Jane J; Perl, Anne Karina; Wikenheiser-Brokamp, Kathryn A; Riccetti, Matt; Zhang, Erik Y; Sudha, Parvathi; Adam, Mike; Potter, Andrew; Kopras, Elizabeth J; Giannikou, Krinio; Potter, S Steven; Sherman, Sue; Hammes, Stephen R; Kwiatkowski, David J; Whitsett, Jeffrey A; McCormack, Francis X; Xu, Yan 2020. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American journal of respiratory and critical care medicine, 202 10, 1373-1387Kosciuk, Patrick; Meyer, Cristopher; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2020. Pulmonary alveolar microlithiasis. European respiratory review : an official journal of the European Respiratory Society, 29 158, Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T 2020. MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI insight, 5 4, Obaidat, Baha; Yazdani, Dina; Wikenheiser-Brokamp, Kathryn A; Gupta, Nishant 2020. Diffuse Cystic Lung Diseases. Respiratory care, 65 1, 111-126Oltvai, Zoltán N; Smith, Eric A; Wiens, Katie; Nogee, Lawrence M; Luquette, Mark; Nelson, Andrew C; Wikenheiser-Brokamp, Kathryn A 2020. Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter. Cold Spring Harbor molecular case studies, 6 3, Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Suzuki, Takuji; McCarthy, Cormac; Carey, Brenna C; Borchers, Michael; Beck, David; Wikenheiser-Brokamp, Kathryn A; Black, Dianna; Chalk, Claudia; Trapnell, Bruce C 2020. Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis. American journal of respiratory cell and molecular biology, 62 1, 87-94Schulert, Grant S; Yasin, Shima; Carey, Brenna; Chalk, Claudia; Do, Thuy; Schapiro, Andrew H; Husami, Ammar; Watts, Allen; Brunner, Hermine I; Huggins, Jennifer; Mellins, Elizabeth D; Morgan, Esi M; Ting, Tracy; Trapnell, Bruce C; Wikenheiser-Brokamp, Kathryn A; Towe, Christopher; Grom, Alexei A 2019. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis & rheumatology (Hoboken, N.J.), 71 11, 1943-1954Suhrie, Kristen; Pajor, Nathan M; Ahlfeld, Shawn K; Dawson, D Brian; Dufendach, Kevin R; Kitzmiller, Joseph A; Leino, Daniel; Lombardo, Rachel C; Smolarek, Teresa A; Rathbun, Pamela A; Whitsett, Jeffrey A; Towe, Christopher; Wikenheiser-Brokamp, Kathryn A 2019. Neonatal Lung Disease Associated with TBX4 Mutations. The Journal of pediatrics, 206 , 286-292.e1Taylor, Deanne M; Aronow, Bruce J; Tan, Kai; Bernt, Kathrin; Salomonis, Nathan; Greene, Casey S; Frolova, Alina; Henrickson, Sarah E; Wells, Andrew; Pei, Liming; Jaiswal, Jyoti K; Whitsett, Jeffrey; Hamilton, Kathryn E; MacParland, Sonya A; Kelsen, Judith; Heuckeroth, Robert O; Potter, S Steven; Vella, Laura A; Terry, Natalie A; Ghanem, Louis R; Kennedy, Benjamin C; Helbig, Ingo; Sullivan, Kathleen E; Castelo-Soccio, Leslie; Kreigstein, Arnold; Herse, Florian; Nawijn, Martijn C; Koppelman, Gerard H; Haendel, Melissa; Harris, Nomi L; Rokita, Jo Lynne; Zhang, Yuanchao; Regev, Aviv; Rozenblatt-Rosen, Orit; Rood, Jennifer E; Tickle, Timothy L; Vento-Tormo, Roser; Alimohamed, Saif; Lek, Monkol; Mar, Jessica C; Loomes, Kathleen M; Barrett, David M; Uapinyoying, Prech; Beggs, Alan H; Agrawal, Pankaj B; Chen, Yi-Wen; Muir, Amanda B; Garmire, Lana X; Snapper, Scott B; Nazarian, Javad; Seeholzer, Steven H; Fazelinia, Hossein; Singh, Larry N; Faryabi, Robert B; Raman, Pichai; Dawany, Noor; Xie, Hongbo Michael; Devkota, Batsal; Diskin, Sharon J; Anderson, Stewart A; Rappaport, Eric F; Peranteau, William; Wikenheiser-Brokamp, Kathryn A; Teichmann, Sarah; Wallace, Douglas; Peng, Tao; Ding, Yang-Yang; Kim, Man S; Xing, Yi; Kong, Sek Won; Bönnemann, Carsten G; Mandl, Kenneth D; White, Peter S 2019. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental cell, 49 1, 10-29Wang, Yuhua; Pandey, Ram Naresh; York, Allen J; Mallela, Jaya; Nichols, William C; Hu, Yueh-Chiang; Molkentin, Jeffery D; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2019. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature communications, 10 1, 4143Gupta, Nishant; Colby, Thomas V; Meyer, Cristopher A; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn A 2018. Smoking-Related Diffuse Cystic Lung Disease. Chest, 154 2, e31-e35Matrka, Marie C; Cimperman, Katherine A; Haas, Sarah R; Guasch, Geraldine; Ehrman, Lisa A; Waclaw, Ronald R; Komurov, Kakajan; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2018. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS genetics, 14 3, e1007227Wang, Yuhua; Pandey, Ram Naresh; Riffle, Stephen; Chintala, Hemabindu; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2018. The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular cancer therapeutics, 17 8, 1659-1669Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A 2018. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 121 2, 179-185Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A 2017. Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response. Molecular cancer therapeutics, , Gupta, N; Wikenheiser-Brokamp, K; Zander, D; Balestra, R; Selvaraju, A; Niehaus, K; Benzaquen, S 2017. Successful diagnosis of lymphangioleiomyomatosis with transbronchial lung cryobiopsy. Lymphology, 50 3, 154-157Gupta, Nishant; Finlay, Geraldine A; Kotloff, Robert M; Strange, Charlie; Wilson, Kevin C; Young, Lisa R; Taveira-DaSilva, Angelo M; Johnson, Simon R; Cottin, Vincent; Sahn, Steven A; Ryu, Jay H; Seyama, Kuniaki; Inoue, Yoshikazu; Downey, Gregory P; Han, MeiLan K; Colby, Thomas V; Wikenheiser-Brokamp, Kathryn A; Meyer, Cristopher A; Smith, Karen; Moss, Joel; McCormack, Francis X 2017. Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline. American journal of respiratory and critical care medicine, 196 10, 1337-1348Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 10, 1318-1330Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A 2017. p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis, 6 4, e320Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia 2017. A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique. Journal of bronchology & interventional pulmonology, 24 2, 131-135Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K 2017. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of pediatrics, 181 , 5-6.e3Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2016. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem cell reports, 6 1, 44-54Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X 2016. Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome. Annals of the American Thoracic Society, 13 3, 371-5McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel 2016. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American journal of respiratory and critical care medicine, 194 6, 748-61Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T 2016. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI insight, 1 16, e87270Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A 2016. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI insight, 1 20, e90558Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A 2015. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene, 34 5, 589-99Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part II. American journal of respiratory and critical care medicine, 192 1, 17-29Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part I. American journal of respiratory and critical care medicine, 191 12, 1354-66Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G 2015. Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships. The Journal of pediatrics, 167 3, 506-7.e1Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I 2015. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 8, 1962-72Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 313, 313ra181Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A 2015. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. The Journal of pathology, 236 1, 41-52Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2014. High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells. Journal of virology, 88 19, 11315-26Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia 2014. Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis. American journal of respiratory and critical care medicine, 189 4, 490-1Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan 2014. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International journal of oncology, 45 3, 978-84McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine 2014. TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development (Cambridge, England), 141 23, 4628-39Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A 2013. Mucoepidermoid carcinoma of the lung: a case report and literature review. Case reports in oncological medicine, 2013 , 625243McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn 2013. An atoll variant that mocks. American journal of respiratory and critical care medicine, 188 1, 110Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M 2013. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 9, 1167-70Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J 2012. Occam's razor or Hickam's dictum? Journal of bronchology & interventional pulmonology, 19 3, 216-9Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The fanconi anemia pathway limits human papillomavirus replication. Journal of virology, 86 15, 8131-8Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X 2012. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Frontiers of medicine, 6 4, 395-405Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X 2012. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Seminars in respiratory and critical care medicine, 33 5, 486-97Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W 2011. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases Chest, 139 2, 353-60Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan 2011. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC cancer, 11 , 513Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer Oncogene, , Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J 2009. DICER1 mutations in familial pleuropulmonary blastoma Science (New York, N.Y.), 325 5943, 965Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis Cancer research, 69 22, 8733-41Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program The American journal of pathology, 174 1, 71-81Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. 2009. Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, 136 3, 962-933Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E 2007. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocrine-related cancer, 14 2, 445-52Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S 2007. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology, 133 3, 976-84Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley . Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 18 6, 504-11
Bedard, Mary C; Brusadelli, Marion G; Carlile, Adrean; Ruiz-Torres, Sonya; Lodin, Hannah; Lee, Denis; Kofron, Matthew; Lambert, Paul F; Lane, Adam; Ameziane, Najim; Bahassi, El Mustapha; Wikenheiser-Brokamp, Kathryn A; de Alarcon, Alessandro; Smith, David F; Wells, Susanne I 2021. Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis. Viruses, 13 1, Bedard, Mary C; de Alarcon, Alessandro; Kou, Yann-Fuu; Lee, David; Sestito, Alexandra; Duggins, Angela L; Brusadelli, Marion; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I; Smith, David F 2021. HPV Strain Predicts Severity of Juvenile-Onset Recurrent Respiratory Papillomatosis with Implications for Disease Screening. Cancers, 13 11, Benzaquen, Sadia; Kaini, Navin; Gupta, Ena; Litwin, Dianne; Wikenheiser-Brokamp, Kathryn A; Aragaki-Nakahodo, Alejandro 2021. Women Presenting With Asthma and Persistent Wheezing: A Case Series. Chest, 159 4, e267-e275Gao, Denny K; Salomonis, Nathan; Henderlight, Maggie; Woods, Christopher; Thakkar, Kairavee; Grom, Alexei A; Thornton, Sherry; Jordan, Michael B; Wikenheiser-Brokamp, Kathryn A; Schulert, Grant S 2021. IFN-? is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome. JCI insight, 6 17, Hawkins, Padraig; Chawke, Liam; Cormican, Liam; Wikenheiser-Brokamp, Kathryn A; Fabre, Aurelie; Keane, Michael P; McCarthy, Cormac 2021. Autoimmune pulmonary alveolar proteinosis: a discrepancy between symptoms and CT findings. Lancet (London, England), 398 10296, e7Hayes, Don; Darland, Leanna K; Hjelm, Michelle A; Mansour, Heidi M; Wikenheiser-Brokamp, Kathryn A 2021. To treat or not to treat: CFTR modulators after lung transplantation. Pediatric transplantation, 25 4, e14007Ogden, Herbert Luke; Kim, Hoyeol; Wikenheiser-Brokamp, Kathryn A; Naren, Anjaparavanda P; Mun, Kyu Shik 2021. Cystic Fibrosis Human Organs-on-a-Chip. Micromachines, 12 7, Pearson, Joel D; Huang, Katherine; Pacal, Marek; McCurdy, Sean R; Lu, Suying; Aubry, Arthur; Yu, Tao; Wadosky, Kristine M; Zhang, Letian; Wang, Tao; Gregorieff, Alex; Ahmad, Mohammad; Dimaras, Helen; Langille, Ellen; Cole, Susan P C; Monnier, Philippe P; Lok, Benjamin H; Tsao, Ming-Sound; Akeno, Nagako; Schramek, Daniel; Wikenheiser-Brokamp, Kathryn A; Knudsen, Erik S; Witkiewicz, Agnieszka K; Wrana, Jeffrey L; Goodrich, David W; Bremner, Rod 2021. Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Cancer cell, 39 8, 1115-1134.e12Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I 2021. Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin. Cell stem cell, 28 3, 424-435.e6Ruiz-Torres, Sonya; Lambert, Paul F; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2021. Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells. Molecular biology reports, 48 8, 6213-6222Guo, Minzhe; Yu, Jane J; Perl, Anne Karina; Wikenheiser-Brokamp, Kathryn A; Riccetti, Matt; Zhang, Erik Y; Sudha, Parvathi; Adam, Mike; Potter, Andrew; Kopras, Elizabeth J; Giannikou, Krinio; Potter, S Steven; Sherman, Sue; Hammes, Stephen R; Kwiatkowski, David J; Whitsett, Jeffrey A; McCormack, Francis X; Xu, Yan 2020. Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell. American journal of respiratory and critical care medicine, 202 10, 1373-1387Kosciuk, Patrick; Meyer, Cristopher; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2020. Pulmonary alveolar microlithiasis. European respiratory review : an official journal of the European Respiratory Society, 29 158, Liu, Huan; Osterburg, Andrew R; Flury, Jennifer; Swank, Zulma; McGraw, Dennis W; Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Kumar, Ashish; Tazi, Abdellatif; Inoue, Yoshikazu; Hirose, Masaki; McCormack, Francis X; Borchers, Michael T 2020. MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI insight, 5 4, Obaidat, Baha; Yazdani, Dina; Wikenheiser-Brokamp, Kathryn A; Gupta, Nishant 2020. Diffuse Cystic Lung Diseases. Respiratory care, 65 1, 111-126Oltvai, Zoltán N; Smith, Eric A; Wiens, Katie; Nogee, Lawrence M; Luquette, Mark; Nelson, Andrew C; Wikenheiser-Brokamp, Kathryn A 2020. Neonatal respiratory failure due to novel compound heterozygous mutations in the ABCA3 lipid transporter. Cold Spring Harbor molecular case studies, 6 3, Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K 2020. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk. Nature communications, 11 1, 4092Suzuki, Takuji; McCarthy, Cormac; Carey, Brenna C; Borchers, Michael; Beck, David; Wikenheiser-Brokamp, Kathryn A; Black, Dianna; Chalk, Claudia; Trapnell, Bruce C 2020. Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis. American journal of respiratory cell and molecular biology, 62 1, 87-94Schulert, Grant S; Yasin, Shima; Carey, Brenna; Chalk, Claudia; Do, Thuy; Schapiro, Andrew H; Husami, Ammar; Watts, Allen; Brunner, Hermine I; Huggins, Jennifer; Mellins, Elizabeth D; Morgan, Esi M; Ting, Tracy; Trapnell, Bruce C; Wikenheiser-Brokamp, Kathryn A; Towe, Christopher; Grom, Alexei A 2019. Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Arthritis & rheumatology (Hoboken, N.J.), 71 11, 1943-1954Suhrie, Kristen; Pajor, Nathan M; Ahlfeld, Shawn K; Dawson, D Brian; Dufendach, Kevin R; Kitzmiller, Joseph A; Leino, Daniel; Lombardo, Rachel C; Smolarek, Teresa A; Rathbun, Pamela A; Whitsett, Jeffrey A; Towe, Christopher; Wikenheiser-Brokamp, Kathryn A 2019. Neonatal Lung Disease Associated with TBX4 Mutations. The Journal of pediatrics, 206 , 286-292.e1Taylor, Deanne M; Aronow, Bruce J; Tan, Kai; Bernt, Kathrin; Salomonis, Nathan; Greene, Casey S; Frolova, Alina; Henrickson, Sarah E; Wells, Andrew; Pei, Liming; Jaiswal, Jyoti K; Whitsett, Jeffrey; Hamilton, Kathryn E; MacParland, Sonya A; Kelsen, Judith; Heuckeroth, Robert O; Potter, S Steven; Vella, Laura A; Terry, Natalie A; Ghanem, Louis R; Kennedy, Benjamin C; Helbig, Ingo; Sullivan, Kathleen E; Castelo-Soccio, Leslie; Kreigstein, Arnold; Herse, Florian; Nawijn, Martijn C; Koppelman, Gerard H; Haendel, Melissa; Harris, Nomi L; Rokita, Jo Lynne; Zhang, Yuanchao; Regev, Aviv; Rozenblatt-Rosen, Orit; Rood, Jennifer E; Tickle, Timothy L; Vento-Tormo, Roser; Alimohamed, Saif; Lek, Monkol; Mar, Jessica C; Loomes, Kathleen M; Barrett, David M; Uapinyoying, Prech; Beggs, Alan H; Agrawal, Pankaj B; Chen, Yi-Wen; Muir, Amanda B; Garmire, Lana X; Snapper, Scott B; Nazarian, Javad; Seeholzer, Steven H; Fazelinia, Hossein; Singh, Larry N; Faryabi, Robert B; Raman, Pichai; Dawany, Noor; Xie, Hongbo Michael; Devkota, Batsal; Diskin, Sharon J; Anderson, Stewart A; Rappaport, Eric F; Peranteau, William; Wikenheiser-Brokamp, Kathryn A; Teichmann, Sarah; Wallace, Douglas; Peng, Tao; Ding, Yang-Yang; Kim, Man S; Xing, Yi; Kong, Sek Won; Bönnemann, Carsten G; Mandl, Kenneth D; White, Peter S 2019. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental cell, 49 1, 10-29Wang, Yuhua; Pandey, Ram Naresh; York, Allen J; Mallela, Jaya; Nichols, William C; Hu, Yueh-Chiang; Molkentin, Jeffery D; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2019. The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension. Nature communications, 10 1, 4143Gupta, Nishant; Colby, Thomas V; Meyer, Cristopher A; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn A 2018. Smoking-Related Diffuse Cystic Lung Disease. Chest, 154 2, e31-e35Matrka, Marie C; Cimperman, Katherine A; Haas, Sarah R; Guasch, Geraldine; Ehrman, Lisa A; Waclaw, Ronald R; Komurov, Kakajan; Lane, Adam; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2018. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS genetics, 14 3, e1007227Wang, Yuhua; Pandey, Ram Naresh; Riffle, Stephen; Chintala, Hemabindu; Wikenheiser-Brokamp, Kathryn A; Hegde, Rashmi S 2018. The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular cancer therapeutics, 17 8, 1659-1669Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A 2018. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 121 2, 179-185Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A 2017. Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response. Molecular cancer therapeutics, , Gupta, N; Wikenheiser-Brokamp, K; Zander, D; Balestra, R; Selvaraju, A; Niehaus, K; Benzaquen, S 2017. Successful diagnosis of lymphangioleiomyomatosis with transbronchial lung cryobiopsy. Lymphology, 50 3, 154-157Gupta, Nishant; Finlay, Geraldine A; Kotloff, Robert M; Strange, Charlie; Wilson, Kevin C; Young, Lisa R; Taveira-DaSilva, Angelo M; Johnson, Simon R; Cottin, Vincent; Sahn, Steven A; Ryu, Jay H; Seyama, Kuniaki; Inoue, Yoshikazu; Downey, Gregory P; Han, MeiLan K; Colby, Thomas V; Wikenheiser-Brokamp, Kathryn A; Meyer, Cristopher A; Smith, Karen; Moss, Joel; McCormack, Francis X 2017. Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline. American journal of respiratory and critical care medicine, 196 10, 1337-1348Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 10, 1318-1330Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A 2017. p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis, 6 4, e320Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia 2017. A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique. Journal of bronchology & interventional pulmonology, 24 2, 131-135Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K 2017. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of pediatrics, 181 , 5-6.e3Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2016. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem cell reports, 6 1, 44-54Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X 2016. Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome. Annals of the American Thoracic Society, 13 3, 371-5McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel 2016. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American journal of respiratory and critical care medicine, 194 6, 748-61Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T 2016. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI insight, 1 16, e87270Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A 2016. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI insight, 1 20, e90558Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A 2015. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene, 34 5, 589-99Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part II. American journal of respiratory and critical care medicine, 192 1, 17-29Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part I. American journal of respiratory and critical care medicine, 191 12, 1354-66Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G 2015. Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships. The Journal of pediatrics, 167 3, 506-7.e1Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I 2015. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 8, 1962-72Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 313, 313ra181Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A 2015. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. The Journal of pathology, 236 1, 41-52Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2014. High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells. Journal of virology, 88 19, 11315-26Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia 2014. Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis. American journal of respiratory and critical care medicine, 189 4, 490-1Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan 2014. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International journal of oncology, 45 3, 978-84McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine 2014. TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development (Cambridge, England), 141 23, 4628-39Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A 2013. Mucoepidermoid carcinoma of the lung: a case report and literature review. Case reports in oncological medicine, 2013 , 625243McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn 2013. An atoll variant that mocks. American journal of respiratory and critical care medicine, 188 1, 110Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M 2013. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 9, 1167-70Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J 2012. Occam's razor or Hickam's dictum? Journal of bronchology & interventional pulmonology, 19 3, 216-9Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The fanconi anemia pathway limits human papillomavirus replication. Journal of virology, 86 15, 8131-8Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X 2012. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Frontiers of medicine, 6 4, 395-405Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X 2012. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Seminars in respiratory and critical care medicine, 33 5, 486-97Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W 2011. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases Chest, 139 2, 353-60Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan 2011. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC cancer, 11 , 513Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer Oncogene, , Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J 2009. DICER1 mutations in familial pleuropulmonary blastoma Science (New York, N.Y.), 325 5943, 965Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis Cancer research, 69 22, 8733-41Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program The American journal of pathology, 174 1, 71-81Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. 2009. Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, 136 3, 962-933Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E 2007. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocrine-related cancer, 14 2, 445-52Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S 2007. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology, 133 3, 976-84Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley . Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 18 6, 504-11