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Photo of  Shekhar Pasare, PhD

Shekhar Pasare, PhD


Pediatrics | College of Medicine

Contact Information
Research Interests

In my research, I pursue topics such as regulation of inflammation, dendritic cell biology, innate immunity, toll-like receptor signaling and the cross-talk between the innate and adaptive immune systems. Our lab’s primary goals are to understand how the innate and adaptive immune system interact with each other and to define the molecules that are part of this interaction.

We are also studying how inflammation is prompted by microbial recognition and during autoimmunity. In general, ...

Peer Reviewed Publications

McDaniel, Margaret M; Chawla, Amanpreet Singh; Jain, Aakanksha; Meibers, Hannah E; Saha, Irene; Gao, Yajing; Jain, Viral; Roskin, Krishna; Way, Sing Sing; Pasare, Chandrashekhar 2022. Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells. Science immunology, 7 67, eabk0182

Brusilovsky, Michael; Rochman, Mark; Rochman, Yrina; Caldwell, Julie M; Mack, Lydia E; Felton, Jennifer M; Habel, Jeff E; Porollo, Aleksey; Pasare, Chandrashekhar; Rothenberg, Marc E 2021. Environmental allergens trigger type 2 inflammation through ripoptosome activation. Nature immunology, 22 10, 1316-1326

McDaniel, Margaret M; Meibers, Hannah E; Pasare, Chandrashekhar 2021. Innate control of adaptive immunity and adaptive instruction of innate immunity: bi-directional flow of information. Current opinion in immunology, 73 , 25-33

Song, Ran; Gao, Yajing; Dozmorov, Igor; Malladi, Venkat; Saha, Irene; McDaniel, Margaret M; Parameswaran, Sreeja; Liang, Chaoying; Arana, Carlos; Zhang, Bo; Wakeland, Benjamin; Zhou, Jinchun; Weirauch, Matthew T; Kottyan, Leah C; Wakeland, Edward K; Pasare, Chandrashekhar 2021. IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility. Cell reports, 34 12, 108891

Antoniou, Konstantina; Ender, Fanny; Vollbrandt, Tillman; Laumonnier, Yves; Rathmann, Franziska; Pasare, Chandrashekhar; Singh, Harinder; Köhl, Jörg 2020. Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b+ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40. Cells, 9 2,

Gao, Yajing; Deason, Krystin; Jain, Aakanksha; Irizarry-Caro, Ricardo A; Dozmorov, Igor; Coughlin, Laura A; Rauch, Isabella; Evers, Bret M; Koh, Andrew Y; Wakeland, Edward K; Pasare, Chandrashekhar 2020. Transcriptional profiling identifies caspase-1 as a T cell-intrinsic regulator of Th17 differentiation. The Journal of experimental medicine, 217 4,

Irizarry-Caro, Ricardo A; McDaniel, Margaret M; Overcast, Garrett R; Jain, Viral G; Troutman, Ty Dale; Pasare, Chandrashekhar 2020. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation. Proceedings of the National Academy of Sciences of the United States of America, 117 48, 30628-30638

Jain, Aakanksha; Irizarry-Caro, Ricardo A; McDaniel, Margaret M; Chawla, Amanpreet Singh; Carroll, Kaitlin R; Overcast, Garrett R; Philip, Naomi H; Oberst, Andrew; Chervonsky, Alexander V; Katz, Jonathan D; Pasare, Chandrashekhar 2020. T cells instruct myeloid cells to produce inflammasome-independent IL-1? and cause autoimmunity. Nature immunology, 21 1, 65-74

Jain, Viral G; Kong, Fansheng; Kallapur, Suhas G; Presicce, Pietro; Senthamaraikannnan, Paranthaman; Cappelletti, Monica; Chougnet, Claire A; Bhattacharyya, Sandip; Pasare, Chandrashekhar; Muglia, Louis J 2020. IRAK1 Is a Critical Mediator of Inflammation-Induced Preterm Birth. Journal of immunology (Baltimore, Md. : 1950), 204 10, 2651-2660

McDaniel, Margaret M; Kottyan, Leah C; Singh, Harinder; Pasare, Chandrashekhar 2020. Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Cell reports, 31 5, 107604

Zhang, Jian; Tracy, Charles; Pasare, Chandrashekhar; Zeng, Jinsheng; Krämer, Helmut 2020. Hypersensitivity of Vps33B mutant flies to non-pathogenic infections is dictated by aberrant activation of p38b MAP kinase. Traffic (Copenhagen, Denmark), 21 9, 578-589

Khan, Arshad; Bakhru, Pearl; Saikolappan, Sankaralingam; Das, Kishore; Soudani, Emily; Singh, Christopher R; Estrella, Jaymie L; Zhang, Dekai; Pasare, Chandrashekhar; Ma, Yue; Sun, Jianjun; Wang, Jin; Hunter, Robert L; Tony Eissa, N; Dhandayuthapani, Subramanian; Jagannath, Chinnaswamy 2019. An autophagy-inducing and TLR-2 activating BCG vaccine induces a robust protection against tuberculosis in mice. NPJ vaccines, 4 , 34

Jain, Aakanksha; Song, Ran; Wakeland, Edward K; Pasare, Chandrashekhar 2018. T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells. Nature communications, 9 1, 3185

Kong, Fansheng; Liu, Zhiwei; Jain, Viral G; Shima, Kenjiro; Suzuki, Takuji; Muglia, Louis J; Starczynowski, Daniel T; Pasare, Chandrashekhar; Bhattacharyya, Sandip 2017. Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages. Journal of immunology (Baltimore, Md. : 1950), 199 10, 3654-3667

Raj, Prithvi; Rai, Ekta; Song, Ran; Khan, Shaheen; Wakeland, Benjamin E; Viswanathan, Kasthuribai; Arana, Carlos; Liang, Chaoying; Zhang, Bo; Dozmorov, Igor; Carr-Johnson, Ferdicia; Mitrovic, Mitja; Wiley, Graham B; Kelly, Jennifer A; Lauwerys, Bernard R; Olsen, Nancy J; Cotsapas, Chris; Garcia, Christine K; Wise, Carol A; Harley, John B; Nath, Swapan K; James, Judith A; Jacob, Chaim O; Tsao, Betty P; Pasare, Chandrashekhar; Karp, David R; Li, Quan Zhen; Gaffney, Patrick M; Wakeland, Edward K 2016. Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. eLife, 5 ,