Contact Information Email vinksa@ucmail.uc.edu Peer Reviewed Publications Cervantes, Francisco C; Mizuno, Tomoyuki; Dong, Min; Tang, Peter; Arbough, Trent; Vinks, Alexander A; Kaplan, Jennifer M; Tang Girdwood, Sonya C 2023. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic drug monitoring, 45 6, 832-836Choi, Yewon; Vinks, Alexander A; van der Graaf, Piet H 2023. Novel Therapeutic Modalities: The Future is Now. Clinical pharmacology and therapeutics, 114 3, 493-496Dong, Min; Ware, Russell E; Dallmann, André; Vinks, Alexander A 2023. Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps. Pharmacotherapy, 43 5, 419-429Jodele, Sonata; Mizuno, Kana; Sabulski, Anthony; Vinks, Alexander A 2023. Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies. Clinical pharmacology and therapeutics, 114 3, 511-514McIntire, Carter; Luna Torres, Julie; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Tang Girdwood, Sonya 2023. Piperacillin Pharmacokinetics and Pharmacodynamics in Paediatric Patients Who Received High Frequency Intra-Operative Piperacillin/Tazobactam Dosing. International journal of antimicrobial agents, 63 3, 107079Mizuno, Kana; Capparelli, Edmund V; Fukuda, Tsuyoshi; Dong, Min; Adamson, Peter C; Blumer, Jeffery L; Cnaan, Avital; Clark, Peggy O; Reed, Michael D; Shinnar, Shlomo; Vinks, Alexander A; Glauser, Tracy A 2023. Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Clinical pharmacology and therapeutics, 114 2, 459-469Pavia, Kathryn; Hambrick, H Rhodes; Paice, Kelli; Tang, Peter; Punt, Nieko; Kaplan, Jennifer; Goldstein, Stuart L; Vinks, Alexander A; Mizuno, Tomoyuki; Tang Girdwood, Sonya 2023. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. The Journal of antimicrobial chemotherapy, 78 9, 2140-2147Poweleit, Ethan A; Vinks, Alexander A; Mizuno, Tomoyuki 2023. Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic drug monitoring, , Power-Hays, Alexandra; Dong, Min; Punt, Nieko; Mizuno, Tomoyuki; Smart, Luke R; Vinks, Alexander A; Ware, Russell E 2023. Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical pharmacology and therapeutics, , Ramsey, Laura B; Prows, Cynthia A; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Quinn, Charles T; Teusink-Cross, Ashley; Girdwood, Sonya Tang; Dawson, D Brian; Vinks, Alexander A; Glauser, Tracy A 2023. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, , Smart, Luke R; Charles, Mwesige; McElhinney, Kathryn E; Dong, Min; Power-Hays, Alexandra; Howard, Thad; Vinks, Alexander A; Ambrose, Emmanuela E; Ware, Russell E 2023. Hydroxyurea pharmacokinetics and precision dosing in low-resource settings. Frontiers in molecular biosciences, 10 , 1130206Tang Girdwood, Sonya; Hasson, Denise; Caldwell, J Timothy; Slagle, Cara; Dong, Shun; Fei, Lin; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Goldstein, Stuart L 2023. Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury. The Journal of antimicrobial chemotherapy, 78 2, 478-487Tang Girdwood, Sonya; Tang, Peter; Fenchel, Matthew; Dong, Min; Stoneman, Erin; Jones, Rhonda; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Diseroad, Emily; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2023. Pharmacokinetic Parameters over Time during Sepsis and the Association of Target Attainment and Outcomes in Critically Ill Children and Young Adults Receiving Ceftriaxone. Pharmacotherapy, , Taylor, Zachary L; Poweleit, Ethan A; Paice, Kelli; Somers, Katherine M; Pavia, Kathryn; Vinks, Alexander A; Punt, Nieko; Mizuno, Tomoyuki; Girdwood, Sonya Tang 2023. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: pharmacometrics & systems pharmacology, 12 12, 1827-1845Chandra, Sharat; Mizuno, Kana; Zhao, Junfang; Davies, Stella M; Marsh, Rebecca A; Fukuda, Tsuyoshi; Setchell, Kenneth D R; Vinks, Alexander A; Mehta, Parinda A 2022. Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders. British journal of clinical pharmacology, 88 1, 115-127Colman, Ruben J; Mizuno, Tomoyuki; Fukushima, Keizo; Haslam, David B; Hyams, Jeffrey S; Boyle, Brendan; Noe, Joshua D; D'Haens, Geert R; Van Limbergen, Johan; Chun, Kelly; Yang, Jane; Denson, Lee A; Ollberding, Nicholas J; Vinks, Alexander A; Minar, Phillip 2022. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary pharmacology & therapeutics, , Colman, Ruben J; Samuels, Abigail; Mizuno, Tomoyuki; Punt, Nieko; Vinks, Alexander A; Minar, Phillip 2022. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases, , Colman, Ruben J; Xiong, Ye; Mizuno, Tomoyuki; Hyams, Jeffrey S; Noe, Joshua D; Boyle, Brendan; D'Haens, Geert R; van Limbergen, Johan; Chun, Kelly; Yang, Jane; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2022. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary pharmacology & therapeutics, 55 5, 593-603Dong, Min; Emoto, Chie; Fukuda, Tsuyoshi; Arnold, Danielle E; Mehta, Parinda A; Marsh, Rebecca A; Vinks, Alexander A 2022. Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation. British journal of clinical pharmacology, 88 1, 248-259Miyagawa, Bradley; Lazear, Danielle; Hooper, David K; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Model-informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient with Posterior Reversible Encephalopathy Syndrome. Therapeutic drug monitoring, , Mizuno, Kana; Dandoy, Christopher E; Teusink-Cross, Ashley; Davies, Stella M; Vinks, Alexander A; Jodele, Sonata 2022. Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT. Blood advances, 6 5, 1454-1463Mizuno, Tomoyuki; Dong, Min; Taylor, Zachary L; Ramsey, Laura B; Vinks, Alexander A 2022. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British journal of clinical pharmacology, 88 4, 1418-1426Tang Girdwood, Sonya; Dong, Min; Tang, Peter; Stoneman, Erin; Jones, Rhonda; Yunger, Toni; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Lahni, Patrick; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2022. Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment. Antimicrobial agents and chemotherapy, 66 1, e0142721Tang Girdwood, Sonya; Pavia, Kathryn; Paice, Kelli; Hambrick, H Rhodes; Kaplan, Jennifer; Vinks, Alexander A 2022. β-lactam precision dosing in critically ill children: Current state and knowledge gaps. Frontiers in pharmacology, 13 , 1044683van Hoogdalem, Matthijs W; Johnson, Trevor N; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott L; Ward, Laura P; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical pharmacology and therapeutics, 111 2, 496-508van Hoogdalem, Matthijs W; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology & therapeutics, 234 , 108045Whaley, Kaitlin G; Xiong, Ye; Karns, Rebekah; Hyams, Jeffrey S; Kugathasan, Subra; Boyle, Brendan M; Walters, Thomas D; Kelsen, Judith; LeLeiko, Neal; Shapiro, Jason; Waddell, Amanda; Fox, Sejal; Bezold, Ramona; Bruns, Stephanie; Widing, Robin; Haberman, Yael; Collins, Margaret H; Mizuno, Tomoyuki; Minar, Phillip; D'Haens, Geert R; Denson, Lee A; Vinks, Alexander A; Rosen, Michael J 2022. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, , Yi, Jae-Sung; Perla, Sravan; Huang, Yan; Mizuno, Kana; Giordano, Frank J; Vinks, Alexander A; Bennett, Anton M 2022. Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. Cardiovascular drugs and therapy, 36 4, 589-604Arnold, Danielle E; Emoto, Chie; Fukuda, Tsuyoshi; Dong, Min; Vinks, Alexander A; Lane, Adam; McIntosh, Kelly; Neumeier, Lisa; Lankester, Arjan C; Achini, Federica; Teusink-Cross, Ashley; Chandra, Sharat; Jordan, Michael B; Nelson, Adam S; Myers, Kasiani C; Davies, Stella M; Mehta, Parinda A; Marsh, Rebecca A 2021. A prospective pilot study of a novel alemtuzumab target concentration intervention strategy. Bone marrow transplantation, 56 12, 3029-3031Barrett, Jeffrey S; Barrett, Ryan F; Vinks, Alexander A 2021. Status Toward the Implementation of Precision Dosing in Children. Journal of clinical pharmacology, 61 Suppl 1 , S36-S51Bergan, Stein; Brunet, Mercè; Hesselink, Dennis A; Johnson-Davis, Kamisha L; Kunicki, Paweł K; Lemaitre, Florian; Marquet, Pierre; Molinaro, Mariadelfina; Noceti, Ofelia; Pattanaik, Smita; Pawinski, Tomasz; Seger, Christoph; Shipkova, Maria; Swen, Jesse J; van Gelder, Teun; Venkataramanan, Raman; Wieland, Eberhard; Woillard, Jean-Baptiste; Zwart, Tom C; Barten, Markus J; Budde, Klemens; Dieterlen, Maja-Theresa; Elens, Laure; Haufroid, Vincent; Masuda, Satohiro; Millan, Olga; Mizuno, Tomoyuki; Moes, Dirk J A R; Oellerich, Michael; Picard, Nicolas; Salzmann, Linda; Tönshoff, Burkhard; van Schaik, Ron H N; Vethe, Nils Tore; Vinks, Alexander A; Wallemacq, Pierre; Åsberg, Anders; Langman, Loralie J 2021. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic drug monitoring, 43 2, 150-200Boucher, Alexander A; Dong, Min; Vinks, Alexander A; Marahatta, Anu; Howard, Thad A; Ware, Russell E; Nathan, Jaimie D; Abu-El-Haija, Maisam; Luchtman-Jones, Lori 2021. Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation. Journal of clinical pharmacology, 61 4, 547-554Dong, Min; Rodriguez, Anna V; Blankenship, Chelsea A; McPhail, Gary; Vinks, Alexander A; Hunter, Lisa L 2021. Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis. The Journal of antimicrobial chemotherapy, 76 11, 2923-2931Girdwood, Sonya Tang; Kaplan, Jennifer; Vinks, Alexander A 2021. Methodologic Progress Note: Opportunistic Sampling for Pharmacology Studies in Hospitalized Children. Journal of hospital medicine, 16 1, 35-37Karkoska, Kristine; Quinn, Charles T; Niss, Omar; Pfeiffer, Amanda; Dong, Min; Vinks, Alexander A; McGann, Patrick T 2021. Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia. American journal of hematology, 96 5, 538-544McPhail, Brooks T; Emoto, Chie; Butler, Dawn; Fukuda, Tsuyoshi; Akinbi, Henry; Vinks, Alexander A 2021. Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches. Journal of clinical pharmacology, 61 7, 857-870Mizuno, Tomoyuki; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott; Ward, Laura; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A 2021. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clinical pharmacokinetics, 60 2, 249-259Neely, Michael N; Vinks, Alexander A 2021. Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing. Clinical pharmacology and therapeutics, 109 1, 22-24Peck, Richard W; Shahin, Mohamed H; Vinks, Alexander A 2021. Precision Dosing: The Clinical Pharmacology of Goldilocks. Clinical pharmacology and therapeutics, 109 1, 11-14Quinn, Charles T; Niss, Omar; Dong, Min; Pfeiffer, Amanda; Korpik, Jennifer; Reynaud, Mary; Bonar, Holly; Kalfa, Theodosia A; Smart, Luke R; Malik, Punam; Ware, Russell E; Vinks, Alexander A; McGann, Patrick T 2021. Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. British journal of haematology, 194 3, 617-625Sebold, Alison J; Day, Alyssa M; Ewen, Joshua; Adamek, Jack; Byars, Anna; Cohen, Bernard; Kossoff, Eric H; Mizuno, Tomoyuki; Ryan, Matthew; Sievers, Jacqueline; Smegal, Lindsay; Suskauer, Stacy J; Thomas, Cameron; Vinks, Alexander; Zabel, T Andrew; Hammill, Adrienne M; Comi, Anne M 2021. Sirolimus Treatment in Sturge-Weber Syndrome. Pediatric neurology, 115 , 29-40Soul, Janet S; Bergin, Ann M; Stopp, Christian; Hayes, Breda; Singh, Avantika; Fortuno, Carmen R; O'Reilly, Deirdre; Krishnamoorthy, Kalpathy; Jensen, Frances E; Rofeberg, Valerie; Dong, Min; Vinks, Alexander A; Wypij, David; Staley, Kevin J 2021. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Annals of neurology, 89 2, 327-340Tang Girdwood, Sonya C; Tang, Peter H; Murphy, Mark E; Chamberlain, Andrea R; Benken, Laura A; Jones, Rhonda L; Stoneman, Erin M; Kaplan, Jennifer M; Vinks, Alexander A 2021. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology, 61 4, 565-573Taylor, Zachary L; Thompson, Lauren E; Bear, Heather; Mizuno, Tomoyuki; Vinks, Alexander A; Ramsey, Laura B 2021. Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clinical and translational science, 14 6, 2267-2277van Gelder, Teun; Vinks, Alexander A 2021. Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing. Clinical pharmacology and therapeutics, 110 2, 273-276van Hoogdalem, Matthijs W; McPhail, Brooks T; Hahn, David; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2021. Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics. Expert opinion on drug metabolism & toxicology, 17 1, 87-103Vinks, Alexander A; Barrett, Jeffrey S 2021. Model-Informed Pediatric Drug Development: Application of Pharmacometrics to Define the Right Dose for Children. Journal of clinical pharmacology, 61 Suppl 1 , S52-S59Weiss, Brian D; Wolters, Pamela L; Plotkin, Scott R; Widemann, Brigitte C; Tonsgard, James H; Blakeley, Jaishri; Allen, Jeffrey C; Schorry, Elizabeth; Korf, Bruce; Robison, Nathan J; Goldman, Stewart; Vinks, Alexander A; Emoto, Chie; Fukuda, Tsuyoshi; Robinson, Coretta T; Cutter, Gary; Edwards, Lloyd; Dombi, Eva; Ratner, Nancy; Packer, Roger; Fisher, Michael J 2021. NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39 7, 797-806Wong, Steven H; Marquet, Pierre; Cattaneo, Dario; Svinarov, Dobrin; Bergan, Stein; Walson, Philip; Vinks, Alexander A; Shipkova, Maria 2021. Therapeutic Drug Monitoring in the Era of Precision Medicine: Achievements, Gaps, and Perspectives-An Interview in Honor of Professor Charles Pippenger. Therapeutic drug monitoring, 43 6, 719-727Wright, Karen D; Yao, Xiaopan; London, Wendy B; Kao, Pei-Chi; Gore, Lia; Hunger, Stephen; Geyer, Russ; Cohen, Kenneth J; Allen, Jeffrey C; Katzenstein, Howard M; Smith, Amy; Boklan, Jessica; Nazemi, Kellie; Trippett, Tanya; Karajannis, Matthias; Herzog, Cynthia; Destefano, Joseph; Direnzo, Jennifer; Pietrantonio, Jay; Greenspan, Lianne; Cassidy, Danielle; Schissel, Debra; Perentesis, John; Basu, Mitali; Mizuno, Tomoyuki; Vinks, Alexander A; Prabhu, Sanjay P; Chi, Susan N; Kieran, Mark W 2021. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma. Pediatric blood & cancer, 68 2, e28787Xiong, Ye; Mizuno, Tomoyuki; Colman, Ruben; Hyams, Jeffrey; Noe, Joshua D; Boyle, Brendan; Tsai, Yi-Ting; Dong, Min; Jackson, Kimberly; Punt, Nieko; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2021. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical pharmacology and therapeutics, 109 6, 1639-1647Zhao, Junfang; Sharat, Chandra; Mehta, Parinda A; Mizuno, Kana; Vinks, Alexander A; Setchell, Kenneth D R 2021. Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan. The journal of applied laboratory medicine, 6 3, 625-636Balyan, Rajiv; Dong, Min; Pilipenko, Valentina; Geisler, Kristie; Vinks, Alexander A; Chidambaran, Vidya 2020. Hydromorphone population pharmacokinetics in pediatric surgical patients. Paediatric anaesthesia, 30 10, 1091-1101Bauman, Laura E; Xiong, Ye; Mizuno, Tomoyuki; Minar, Philip; Fukuda, Tsuyoshi; Dong, Min; Rosen, Michael J; Vinks, Alexander A 2020. Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases, 26 3, 429-439Cazelles, Remi; Shukla, Rajendra P; Ware, Russell E; Vinks, Alexander A; Ben-Yoav, Hadar 2020. Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS2-Modified Electrodes and Chemometrics. Biomedicines, 9 1, Chen, Yewei; Sun, Li; Xu, Hong; Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A; Brunner, Hermine I; Li, Yifan; Li, Zhiping 2020. PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing. Frontiers in pharmacology, 11 , 605060Emoto, Chie; Hahn, David; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2020. Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates. Clinical pharmacology and therapeutics, 107 2, 319-320Euteneuer, Joshua C; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Zhao, Junfang; Setchell, Kenneth D R; Muglia, Louis J; Vinks, Alexander A 2020. Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants. Therapeutic drug monitoring, 42 5, 778-786Hahn, David; Fukuda, Tsuyoshi; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Sadhasivam, Senthilkumar; Emoto, Chie 2020. Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients. Journal of clinical pharmacology, 60 8, 992-998McPhail, Brooks T; Emoto, Chie; Fukuda, Tsuyoshi; Butler, Dawn; Wiles, Jason R; Akinbi, Henry; Vinks, Alexander A 2020. Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. Journal of clinical pharmacology, 60 4, 453-465Meier, Emily R; Creary, Susan E; Heeney, Matthew M; Dong, Min; Appiah-Kubi, Abena O; Nelson, Stephen C; Niss, Omar; Piccone, Connie; Quarmyne, Maa-Ohui; Quinn, Charles T; Saving, Kay L; Scott, John P; Talati, Ravi; Latham, Teresa S; Pfeiffer, Amanda; Shook, Lisa M; Vinks, Alexander A; Lane, Adam; McGann, Patrick T 2020. Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia. Trials, 21 1, 983Somberg, John C; Vinks, Alexander A; Dong, Min; Molnar, Janos 2020. Model-Informed Development of Sotalol Loading and Dose Escalation Employing an Intravenous Infusion. Cardiology research, 11 5, 294-304Tang Girdwood, Sonya; Arbough, Trent; Dong, Min; Mizuno, Tomoyuki; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer 2020. Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets. Pharmacotherapy, 40 10, 1061-1068Taylor, Zachary L; Mizuno, Tomoyuki; Punt, Nieko C; Baskaran, Balaji; Navarro Sainz, Adriana; Shuman, William; Felicelli, Nicholas; Vinks, Alexander A; Heldrup, Jesper; Ramsey, Laura B 2020. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical pharmacology and therapeutics, 108 3, 635-643Ullrich, Nicole J; Prabhu, Sanjay P; Reddy, Alyssa T; Fisher, Michael J; Packer, Roger; Goldman, Stewart; Robison, Nathan J; Gutmann, David H; Viskochil, David H; Allen, Jeffrey C; Korf, Bruce; Cantor, Alan; Cutter, Gary; Thomas, Coretta; Perentesis, John P; Mizuno, Tomoyuki; Vinks, Alexander A; Manley, Peter E; Chi, Susan N; Kieran, Mark W 2020. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro-oncology, 22 10, 1527-1535van Hoogdalem, Matthijs W; Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Mehta, Parinda A; Vinks, Alexander A 2020. Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients. British journal of clinical pharmacology, 86 5, 933-943Vinks, Alexander A; Peck, Richard W; Neely, Michael; Mould, Diane R 2020. Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs. Clinical pharmacology and therapeutics, 107 1, 129-135Vinks, Alexander A; Punt, Nieko C; Menke, Frank; Kirkendall, Eric; Butler, Dawn; Duggan, Thomas J; Cortezzo, DonnaMaria E; Kiger, Sam; Dietrich, Tom; Spencer, Paul; Keefer, Rob; Setchell, Kenneth D R; Zhao, Junfang; Euteneuer, Joshua C; Mizuno, Tomoyuki; Dufendach, Kevin R 2020. Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical pharmacology and therapeutics, 107 1, 186-194Ware, Russell E; Marahatta, Anu; Ware, Julie L; McElhinney, Kathryn; Dong, Min; Vinks, Alexander A 2020. Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS). The Journal of pediatrics, 222 , 236-239Boucher, Alexander A; Mizuno, Tomoyuki; Vinks, Alexander A; Goldstein, Stuart L; Tiao, Greg M; Geller, James I 2019. Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma. Pediatric blood & cancer, 66 1, e27425Brunet, Mercè; van Gelder, Teun; Åsberg, Anders; Haufroid, Vincent; Hesselink, Dennis A; Langman, Loralie; Lemaitre, Florian; Marquet, Pierre; Seger, Christoph; Shipkova, Maria; Vinks, Alexander; Wallemacq, Pierre; Wieland, Eberhard; Woillard, Jean Baptiste; Barten, Markus J; Budde, Klemens; Colom, Helena; Dieterlen, Maja-Theresa; Elens, Laure; Johnson-Davis, Kamisha L; Kunicki, Paweł K; MacPhee, Iain; Masuda, Satohiro; Mathew, Binu S; Millán, Olga; Mizuno, Tomoyuki; Moes, Dirk-Jan A R; Monchaud, Caroline; Noceti, Ofelia; Pawinski, Tomasz; Picard, Nicolas; van Schaik, Ron; Sommerer, Claudia; Vethe, Nils Tore; de Winter, Brenda; Christians, Uwe; Bergan, Stein 2019. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Therapeutic drug monitoring, 41 3, 261-307Emoto, Chie; Johnson, Trevor N; Hahn, David; Christians, Uwe; Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition. CPT: pharmacometrics & systems pharmacology, 8 5, 273-284Euteneuer, Joshua C; Kamatkar, Suyog; Fukuda, Tsuyoshi; Vinks, Alexander A; Akinbi, Henry T 2019. Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy. Journal of clinical pharmacology, 59 2, 168-176Hahn, David; Emoto, Chie; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study. Clinical pharmacology and therapeutics, 105 3, 761-768Leino, Abbie D; Emoto, Chie; Fukuda, Tsuyoshi; Privitera, Michael; Vinks, Alexander A; Alloway, Rita R 2019. Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 10, 2944-2948Leino, Abbie D; King, Eileen C; Jiang, Wenlei; Vinks, Alexander A; Klawitter, Jost; Christians, Uwe; Woodle, E Steve; Alloway, Rita R; Rohan, Jennifer M 2019. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 5, 1410-1420Lichvar, Alicia; Tremblay, Simon; Naik, Devanshi; Lipscomb, Jessi; King, Eileen; Vinks, Alexander A; Christians, Uwe; Alloway, Rita R 2019. Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients. Pharmacotherapy, 39 5, 564-575McGann, Patrick T; Niss, Omar; Dong, Min; Marahatta, Anu; Howard, Thad A; Mizuno, Tomoyuki; Lane, Adam; Kalfa, Theodosia A; Malik, Punam; Quinn, Charles T; Ware, Russell E; Vinks, Alexander A 2019. Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia. American journal of hematology, 94 8, 871-879Mehta, Parinda A; Emoto, Chie; Fukuda, Tsuyoshi; Seyboth, Brian; Teusink-Cross, Ashley; Davies, Stella M; Wilhelm, Jamie; Fuller, Kirsten; Vinks, Alexander A; Boulad, Farid 2019. Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different? Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 25 12, 2416-2421Mizuno, Tomoyuki; Gist, Katja M; Gao, Zhiqian; Wempe, Michael F; Alten, Jeffrey; Cooper, David S; Goldstein, Stuart L; Vinks, Alexander A 2019. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clinical pharmacokinetics, 58 6, 793-803Mizuno, Tomoyuki; O'Brien, Maureen M; Vinks, Alexander A 2019. Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128 , 209-214Ramsey, Laura B; Mizuno, Tomoyuki; Vinks, Alexander A; O'Brien, Maureen M 2019. Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib. Pediatric blood & cancer, 66 5, e27618Ramsey, Laura B; Prows, Cynthia A; Zhang, Kejian; Saldaña, Shannon N; Sorter, Michael T; Pestian, John P; Wenstrup, Richard J; Vinks, Alexander A; Glauser, Tracy A 2019. Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine. Clinical pharmacology and therapeutics, 105 1, 49-52Soul, Janet S; Pressler, Ronit; Allen, Marilee; Boylan, Geraldine; Rabe, Heike; Portman, Ron; Hardy, Pollyanna; Zohar, Sarah; Romero, Klaus; Tseng, Brian; Bhatt-Mehta, Varsha; Hahn, Cecil; Denne, Scott; Auvin, Stephane; Vinks, Alexander; Lantos, John; Marlow, Neil; Davis, Jonathan M 2019. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatric research, 85 7, 943-954Tang Girdwood, Sonya C; Mizuno, Tomoyuki; Krallman, Kelli A; Benken, Laura A; Stoneman, Erin M; Yunger, Toni M; Wong, Hector R; Vinks, Alexander A; Kaplan, Jennifer M 2019. Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children. The Pediatric infectious disease journal, 38 12, 1224-1227Vinks, Alexander A 2019. From Molecule to Patient and Ways to Get the Dose Precisely Right. Clinical pharmacology and therapeutics, 105 3, 534-537Berry, Susan A; Vockley, Jerry; Vinks, Alexander A; Dong, Min; Diaz, George A; McCandless, Shawn E; Smith, Wendy E; Harding, Cary O; Zori, Roberto; Ficicioglu, Can; Lichter-Konecki, Uta; Perdok, Renee; Robinson, Beth; Holt, Robert J; Longo, Nicola 2018. Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders. Molecular genetics and metabolism, 125 3, 251-257Chandra, Sharat; Fukuda, Tsuyoshi; Mizuno, Kana; Davies, Stella M; Teusink-Cross, Ashley; Tarin, Rich; Marsh, Rebecca A; Vinks, Alexander A; Mehta, Parinda A 2018. Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study. The Journal of antimicrobial chemotherapy, 73 6, 1651-1658Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2018. Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management. British journal of clinical pharmacology, 84 7, 1410-1412Emoto, Chie; Johnson, Trevor N; McPhail, Brooks T; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations. CPT: pharmacometrics & systems pharmacology, 7 4, 237-250Emoto, Chie; Johnson, Trevor N; Neuhoff, Sibylle; Hahn, David; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants. CPT: pharmacometrics & systems pharmacology, 7 7, 464-473Farag, Elmoubasher; Sikkema, Reina S; Vinks, Tinka; Islam, Md Mazharul; Nour, Mohamed; Al-Romaihi, Hamad; Al Thani, Mohammed; Atta, Muzzamil; Alhajri, Farhoud H; Al-Marri, Salih; AlHajri, Mohd; Reusken, Chantal; Koopmans, Marion 2018. Drivers of MERS-CoV Emergence in Qatar. Viruses, 11 1, Gist, Katja M; Cooper, David S; Wrona, Julia; Faubel, Sarah; Altmann, Christopher; Gao, Zhiqian; Marino, Bradley S; Alten, Jeffrey; Hock, Kristal M; Mizuno, Tomoyuki; Vinks, Alexander A; Joy, Melanie S; Wempe, Michael F; Bennett, Michael R; Goldstein, Stuart L 2018. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Therapeutic drug monitoring, 40 2, 186-194Kaplan, Jennifer M; Zingarelli, Basilia; Krallman, Kelli; Tang Girdwood, Sonya; Lagory, Denise; Mizuno, Tomoyuki; Fei, Lin; Wong, Hector R; Vinks, Alexander A 2018. Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial. Intensive care medicine, 44 11, 2006-2008Miller, J W; Balyan, R; Dong, M; Mahmoud, M; Lam, J E; Pratap, J N; Paquin, J R; Li, B L; Spaeth, J P; Vinks, A; Loepke, A W 2018. Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study. British journal of anaesthesia, 120 5, 1056-1065Mizuno, Kana; Dong, Min; Fukuda, Tsuyoshi; Chandra, Sharat; Mehta, Parinda A; McConnell, Scott; Anaissie, Elias J; Vinks, Alexander A 2018. Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation. Clinical pharmacokinetics, 57 5, 625-636Ramsey, Laura B; Balis, Frank M; O'Brien, Maureen M; Schmiegelow, Kjeld; Pauley, Jennifer L; Bleyer, Archie; Widemann, Brigitte C; Askenazi, David; Bergeron, Sharon; Shirali, Anushree; Schwartz, Stefan; Vinks, Alexander A; Heldrup, Jesper 2018. Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance. The oncologist, 23 1, 52-61Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; King, Eileen C; Zou, Yuanshu; Jiang, Wenlei; Woodle, E Steve; Tremblay, Simon; Klawitter, Jelena; Klawitter, Jost; Christians, Uwe 2017. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS medicine, 14 11, e1002428Balyan, Rajiv; Mecoli, Marc; Venkatasubramanian, Raja; Chidambaran, Vidya; Kamos, Nichole; Clay, Smokey; Moore, David L; Mavi, Jagroop; Glover, Chris D; Szmuk, Peter; Vinks, Alexander; Sadhasivam, Senthilkumar 2017. CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients. Pharmacogenomics, 18 4, 337-348Balyan, Rajiv; Zhang, Xue; Chidambaran, Vidya; Martin, Lisa J; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Vinks, Alexander A; Sadhasivam, Senthilkumar 2017. OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children. Pharmacogenomics, 18 7, 621-629Cabrera-Salcedo, Catalina; Mizuno, Tomoyuki; Tyzinski, Leah; Andrew, Melissa; Vinks, Alexander A; Frystyk, Jan; Wasserman, Halley; Gordon, Catherine M; Hwa, Vivian; Backeljauw, Philippe; Dauber, Andrew 2017. Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density. The Journal of clinical endocrinology and metabolism, 102 12, 4568-4577Chidambaran, V; Venkatasubramanian, R; Zhang, X; Martin, L J; Niu, J; Mizuno, T; Fukuda, T; Meller, J; Vinks, A A; Sadhasivam, S 2017. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. The pharmacogenomics journal, 17 2, 162-169Chidambaran, Vidya; Pilipenko, Valentina; Spruance, Kristie; Venkatasubramanian, Raja; Niu, Jing; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Zhang, Kejian; Kaufman, Kenneth; Vinks, Alexander A; Martin, Lisa J; Sadhasivam, Senthilkumar 2017. Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children. Pharmacogenomics, 18 2, 143-156Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; Reny, J-L; Marsousi, N; Daali, Y; Fairman, D; Cook, J; Lesko, L J; McCune, J S; Knibbe, Caj; de Wildt, S N; Leeder, J S; Neely, M; Zuppa, A F; Vicini, P; Aarons, L; Johnson, T N; Boiani, J; Rostami-Hodjegan, A 2017. Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clinical pharmacology and therapeutics, 101 5, 646-656Diwan, Tayyab S; Lichvar, Alicia B; Leino, Abbie D; Vinks, Alexander A; Christians, Uwe; Shields, Adele R; Cardi, Michael A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Kaiser, Tiffany; Woodle, E Steve; Alloway, Rita R 2017. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clinical transplantation, 31 6, Dong, Min; Fukuda, Tsuyoshi; Selim, Sally; Smith, Mark A; Rabinovich-Guilatt, Laura; Cassella, James V; Vinks, Alexander A 2017. Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents. Clinical pharmacokinetics, 56 10, 1207-1217Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A 2017. Opportunities for model-based precision dosing in the treatment of sickle cell anemia. Blood cells, molecules & diseases, 67 , 143-147Downes, Kevin J; Dong, Min; Fukuda, Tsuyoshi; Clancy, John P; Haffner, Christopher; Bennett, Michael R; Vinks, Alexander A; Goldstein, Stuart L 2017. Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis. The Journal of antimicrobial chemotherapy, 72 1, 254-260Emoto, C; Fukuda, T; Johnson, T N; Neuhoff, S; Sadhasivam, S; Vinks, A A 2017. Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter. CPT: pharmacometrics & systems pharmacology, 6 2, 110-119Faircloth, Jenna M; Miner, Kristin M; Alsaied, Tarek; Nelson, Nicole; Ciambarella, Julie; Mizuno, Tomoyuki; Palumbo, Joseph S; Vinks, Alexander A; Veldtman, Gruschen R 2017. Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients. Journal of thrombosis and thrombolysis, 44 1, 38-47Faircloth, Jenna M; Roe, Olivia; Alsaied, Tarek; Palumbo, Joseph S; Vinks, Alexander; Veldtman, Gruschen R 2017. Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations. Journal of thrombosis and thrombolysis, 44 3, 275-280Hahn, David; Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2017. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children. Drug metabolism and disposition: the biological fate of chemicals, 45 1, 23-26Marsh, Rebecca A; Fukuda, Tsuyoshi; Emoto, Chie; Neumeier, Lisa; Khandelwal, Pooja; Chandra, Sharat; Teusink-Cross, Ashley; Vinks, Alexander A; Mehta, Parinda A 2017. Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 23 4, 635-641Mizuno, Tomoyuki; Emoto, Chie; Fukuda, Tsuyoshi; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109S , S124-S131Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Christians, Uwe; Perentesis, John P; Fouladi, Maryam; Vinks, Alexander A 2017. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. British journal of clinical pharmacology, 83 5, 1097-1107Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Emoto, Chie; Mobberley-Schuman, Paula S; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatric blood & cancer, 64 8, Ramsey, L B; Mizuno, T; Vinks, A A; Margolis, P A 2017. Learning Health Systems as Facilitators of Precision Medicine. Clinical pharmacology and therapeutics, 101 3, 359-367Rohan, Jennifer M; Fukuda, Tsuyoshi; Alderfer, Melissa A; Wetherington Donewar, Crista; Ewing, Linda; Katz, Ernest R; Muriel, Anna C; Vinks, Alexander A; Drotar, Dennis 2017. Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation. Journal of pediatric psychology, 42 2, 232-244Selim, Sally; Riesenberg, Robert; Cassella, James; Kunta, Jeevan; Hellriegel, Edward; Smith, Mark A; Vinks, Alexander A; Rabinovich-Guilatt, Laura 2017. Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents. Journal of clinical pharmacology, 57 10, 1244-1257Varnell, Charles D; Fukuda, Tsuyoshi; Kirby, Cassie L; Martin, Lisa J; Warshaw, Barry L; Patel, Hiren P; Chand, Deepa H; Barletta, Gina-Marie; Van Why, Scott K; VanDeVoorde, Rene G; Weaver, Donald J; Wilson, Amy; Verghese, Priya S; Vinks, Alexander A; Greenbaum, Larry A; Goebel, Jens; Hooper, David K 2017. Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs. Pediatric transplantation, 21 7, Vinks, A A 2017. Precision Medicine-Nobody Is Average. Clinical pharmacology and therapeutics, 101 3, 304-307Xiong, Ye; Fukuda, Tsuyoshi; Knibbe, Catherijne A J; Vinks, Alexander A 2017. Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies. Pediatric clinics of North America, 64 6, 1417-1438Yu, Tian; Enioutina, Elena Y; Brunner, Hermine I; Vinks, Alexander A; Sherwin, Catherine M 2017. Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clinical pharmacokinetics, 56 2, 107-125Adams, Denise M; Trenor, Cameron C; Hammill, Adrienne M; Vinks, Alexander A; Patel, Manish N; Chaudry, Gulraiz; Wentzel, Mary Sue; Mobberley-Schuman, Paula S; Campbell, Lisa M; Brookbank, Christine; Gupta, Anita; Chute, Carol; Eile, Jennifer; McKenna, Jesse; Merrow, Arnold C; Fei, Lin; Hornung, Lindsey; Seid, Michael; Dasgupta, A Roshni; Dickie, Belinda H; Elluru, Ravindhra G; Lucky, Anne W; Weiss, Brian; Azizkhan, Richard G 2016. Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies. Pediatrics, 137 2, e20153257Arya, Ravindra; Gillespie, Catherine W; Cnaan, Avital; Devarajan, Mahima; Clark, Peggy; Shinnar, Shlomo; Vinks, Alexander A; Mizuno, Kana; Glauser, Tracy A 2016. Obesity and overweight as CAE comorbidities and differential drug response modifiers. Neurology, 86 17, 1613-21Cvijanovich, Natalie Z; King, Janet C; Flori, Heidi R; Gildengorin, Ginny; Vinks, Alexander A; Wong, Hector R 2016. Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness. JPEN. Journal of parenteral and enteral nutrition, 40 6, 860-8Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2016. Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia. British journal of clinical pharmacology, 81 4, 742-52Downes, Kevin J; Goldstein, Stuart L; Vinks, Alexander A 2016. Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe. Journal of the Pediatric Infectious Diseases Society, 5 1, 65-7Emoto, C; Fukuda, T; Mizuno, T; Schniedewind, B; Christians, Uwe; Adams, D M; Vinks, A A 2016. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 5 8, 411-7Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2016. Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. Therapeutic drug monitoring, 38 5, 607-13Gist, Katja M; Goldstein, Stuart L; Joy, Melanie S; Vinks, Alexander A 2016. Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review. Journal of cardiovascular pharmacology, 67 2, 175-81Hahn, Andrea; Fukuda, Tsuyoshi; Hahn, David; Mizuno, Tomoyuki; Frenck, Robert W; Vinks, Alexander A 2016. Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia. Pharmacogenomics, 17 6, 547-59Jodele, Sonata; Fukuda, Tsuyoshi; Mizuno, Kana; Vinks, Alexander A; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Chima, Ranjit S; Hirsch, Russel; Teusink, Ashley; Lazear, Danielle; Lane, Adam; Myers, Kasiani C; Dandoy, Christopher E; Davies, Stella M 2016. Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 2, 307-315Khandelwal, Pooja; Emoto, Chie; Fukuda, Tsuyoshi; Vinks, Alexander A; Neumeier, Lisa; Dandoy, Christopher E; El-Bietar, Javier; Chandra, Sharat; Davies, Stella M; Bleesing, Jacob J; Jordan, Michael B; Mehta, Parinda A; Jodele, Sonata; Grimley, Michael S; Kumar, Ashish; Myers, Kasiani C; Marsh, Rebecca A 2016. A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 12, 2220-2225Khandelwal, Pooja; Fukuda, Tsuyoshi; Mizuno, Kana; Teusink-Cross, Ashley; Mehta, Parinda A; Marsh, Rebecca A; Kashuba, Angela D M; Vinks, Alexander A; Davies, Stella M 2016. A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 10, 1829-1835Nehus, Edward J; Mizuno, Tomoyuki; Cox, Shareen; Goldstein, Stuart L; Vinks, Alexander A 2016. Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations. Journal of clinical pharmacology, 56 3, 291-7Ngamprasertwong, Pornswan; Dong, Min; Niu, Jing; Venkatasubramanian, Raja; Vinks, Alexander A; Sadhasivam, Senthilkumar 2016. Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model. PloS one, 11 1, e0146563Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2016. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum. Therapeutic drug monitoring, 38 2, 284Teusink, Ashley; Vinks, Alexander; Zhang, Kejian; Davies, Stella; Fukuda, Tsuyoshi; Lane, Adam; Nortman, Shannon; Kissell, Diane; Dell, Sarah; Filipovich, Alexandra; Mehta, Parinda 2016. Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 3, 482-6Vinks, Alexander A 2016. Therapeutic Optimization as Part of the Precision Medicine Paradigm. Clinical pharmacology and therapeutics, 99 4, 340-2Birdwell, K A; Decker, B; Barbarino, J M; Peterson, J F; Stein, C M; Sadee, W; Wang, D; Vinks, A A; He, Y; Swen, J J; Leeder, J S; van Schaik, Rhn; Thummel, K E; Klein, T E; Caudle, K E; MacPhee, I A M 2015. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical pharmacology and therapeutics, 98 1, 19-24Brouwer, K L R; Aleksunes, L M; Brandys, B; Giacoia, G P; Knipp, G; Lukacova, V; Meibohm, B; Nigam, S K; Rieder, M; de Wildt, S N 2015. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical pharmacology and therapeutics, 98 3, 266-87Chidambaran, Vidya; Venkatasubramanian, Raja; Sadhasivam, Senthilkumar; Esslinger, Hope; Cox, Shareen; Diepstraten, Jeroen; Fukuda, Tsuyoshi; Inge, Thomas; Knibbe, Catherijne A J; Vinks, Alexander A 2015. Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. Paediatric anaesthesia, 25 9, 911-923Christians, Uwe; Vinks, Alexander A; Langman, Loralie J; Clarke, William; Wallemacq, Pierre; van Gelder, Teun; Renjen, Varun; Marquet, Pierre; Meyer, Eric J 2015. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Therapeutic drug monitoring, 37 6, 718-24Emoto, C; Fukuda, T; Johnson, T N; Adams, D M; Vinks, A A 2015. Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 4 2, e17Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2015. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Therapeutic drug monitoring, 37 3, 395-9Emoto, Chie; Fukuda, Tsuyoshi; Venkatasubramanian, Raja; Vinks, Alexander A 2015. The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model. British journal of clinical pharmacology, 80 6, 1438-46Fouladi, Maryam; Perentesis, John P; Wagner, Lars M; Vinks, Alexander A; Reid, Joel M; Ahern, Charlotte; Thomas, George; Mercer, Carol A; Krueger, Darcy A; Houghton, Peter J; Doyle, L Austin; Chen, Helen; Weigel, Brenda; Blaney, Susan M 2015. A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 7, 1558-65Gist, Katja M; Mizuno, Tomoyuki; Goldstein, Stuart L; Vinks, Alexander 2015. Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury. Therapeutic drug monitoring, 37 6, 792-6Hahn, Andrea; Frenck, Robert W; Allen-Staat, Mary; Zou, Yuanshu; Vinks, Alexander A 2015. Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia. Therapeutic drug monitoring, 37 5, 619-25Hahn, Andrea; Frenck, Robert W; Zou, Yuanshu; Vinks, Alexander A 2015. Validation of a pediatric population pharmacokinetic model for vancomycin. Therapeutic drug monitoring, 37 3, 413-6Rosen, M J; Minar, P; Vinks, A A 2015. Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply. Alimentary pharmacology & therapeutics, 42 2, 241Rosen, M J; Minar, P; Vinks, A A 2015. Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis. Alimentary pharmacology & therapeutics, 41 11, 1094-103Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming; Clark, Peggy; Dlugos, Dennis; Hirtz, Deborah G; Masur, David; Mizrahi, Eli M; Moshé, Solomon L; Glauser, Tracy A 2015. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology, 85 13, 1108-14Shokati, Touraj; Bodenberger, Nicholas; Gadpaille, Holly; Schniedewind, Björn; Vinks, Alexander A; Jiang, Wenlei; Alloway, Rita R; Christians, Uwe 2015. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. Journal of visualized experiments : JoVE, 105, e52424Vinks, A A; Emoto, C; Fukuda, T 2015. Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children. Clinical pharmacology and therapeutics, 98 3, 298-308Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander; Cantor, Alan; Perentesis, John; Schorry, Elizabeth; Ullrich, Nicole; Gutmann, David H; Tonsgard, James; Viskochil, David; Korf, Bruce; Packer, Roger J; Fisher, Michael J 2015. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro-oncology, 17 4, 596-603Wiles, Jason R; Isemann, Barbara; Mizuno, Tomoyuki; Tabangin, Meredith E; Ward, Laura P; Akinbi, Henry; Vinks, Alexander A 2015. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. The Journal of pediatrics, 167 6, 1214-20.e3Yang, Xiaoyan; Sherwin, Catherine M T; Yu, Tian; Yellepeddi, Venkata K; Brunner, Hermine I; Vinks, Alexander A 2015. Pharmacokinetic modeling of therapies for systemic lupus erythematosus. Expert review of clinical pharmacology, 8 5, 587-603Dong, Min; Fukuda, Tsuyoshi; Cox, Shareen; de Vries, Marij T; Hooper, David K; Goebel, Jens; Vinks, Alexander A 2014. Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period. British journal of clinical pharmacology, 78 5, 1102-12Dong, Min; Fukuda, Tsuyoshi; Vinks, Alexander A 2014. Optimization of mycophenolic acid therapy using clinical pharmacometrics. Drug metabolism and pharmacokinetics, 29 1, 4-11Downes, Kevin J; Hahn, Andrea; Wiles, Jason; Courter, Joshua D; Vinks, Alexander A 2014. Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics. International journal of antimicrobial agents, 43 3, 223-30Filler, Guido; Vinks, Alexander A; Huang, Shih-Han S; Jevnikar, Anthony; Muirhead, Norman 2014. Similar MPA exposure on modified release and regular tacrolimus. Therapeutic drug monitoring, 36 3, 353-7Jarvik, Gail P; Amendola, Laura M; Berg, Jonathan S; Brothers, Kyle; Clayton, Ellen W; Chung, Wendy; Evans, Barbara J; Evans, James P; Fullerton, Stephanie M; Gallego, Carlos J; Garrison, Nanibaa' A; Gray, Stacy W; Holm, Ingrid A; Kullo, Iftikhar J; Lehmann, Lisa Soleymani; McCarty, Cathy; Prows, Cynthia A; Rehm, Heidi L; Sharp, Richard R; Salama, Joseph; Sanderson, Saskia; Van Driest, Sara L; Williams, Marc S; Wolf, Susan M; Wolf, Wendy A ; Burke, Wylie 2014. Return of genomic results to research participants: the floor, the ceiling, and the choices in between. American journal of human genetics, 94 6, 818-26Jodele, Sonata; Fukuda, Tsuyoshi; Vinks, Alexander; Mizuno, Kana; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Teusink, Ashley; Pluthero, Fred G; Lu, Lily; Licht, Christoph; Davies, Stella M 2014. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20 4, 518-25Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Masuda, Satohiro; Uemoto, Shinji; Matsubara, Kazuo; Inui, Ken-Ichi; Vinks, Alexander A 2014. Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children. British journal of clinical pharmacology, 77 5, 910-2Mizuno, Tomoyuki; Fukudo, Masahide; Fukuda, Tsuyoshi; Terada, Tomohiro; Dong, Min; Kamba, Tomomi; Yamasaki, Toshinari; Ogawa, Osamu; Katsura, Toshiya; Inui, Ken-Ichi; Vinks, Alexander A; Matsubara, Kazuo 2014. The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma. Therapeutic drug monitoring, 36 3, 310-6Nehus, Edward J; Mouksassi, Samer; Vinks, Alexander A; Goldstein, Stuart 2014. Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates. Journal of clinical pharmacology, 54 12, 1421-8Rasmussen-Torvik, L J; Stallings, S C; Gordon, A S; Almoguera, B; Basford, M A; Bielinski, S J; Brautbar, A; Brilliant, M H; Carrell, D S; Connolly, J J; Crosslin, D R; Doheny, K F; Gallego, C J; Gottesman, O; Kim, D S; Leppig, K A; Li, R; Lin, S; Manzi, S; Mejia, A R; Pacheco, J A; Pan, V; Pathak, J; Perry, C L; Peterson, J F; Prows, C A; Ralston, J; Rasmussen, L V; Ritchie, M D; Sadhasivam, S; Scott, S A; Smith, M; Vega, A; Vinks, A A; Volpi, S; Wolf, W A; Bottinger, E; Chisholm, R L; Chute, C G; Haines, J L; Harley, J B; Keating, B; Holm, I A; Kullo, I J; Jarvik, G P; Larson, E B; Manolio, T; McCarty, C A; Nickerson, D A; Scherer, S E; Williams, M S; Roden, D M; Denny, J C 2014. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clinical pharmacology and therapeutics, 96 4, 482-9Roberts, Jason A; Abdul-Aziz, Mohd H; Lipman, Jeffrey; Mouton, Johan W; Vinks, Alexander A; Felton, Timothy W; Hope, William W; Farkas, Andras; Neely, Michael N; Schentag, Jerome J; Drusano, George; Frey, Otto R; Theuretzbacher, Ursula; Kuti, Joseph L 2014. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. The Lancet. Infectious diseases, 14 6, 498-509Sherwin, Catherine M T; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar; Vinks, Alexander A 2014. Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study. Current clinical pharmacology, 9 1, 64-9Smits, Thomas A; Cox, Shareen; Fukuda, Tsuyoshi; Sherbotie, Joseph R; Ward, Robert M; Goebel, Jens; Vinks, Alexander A 2014. Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients. Therapeutic drug monitoring, 36 6, 716-23Venkatasubramanian, Raja; Fukuda, Tsuyoshi; Niu, Jing; Mizuno, Tomoyuki; Chidambaran, Vidya; Vinks, Alexander A; Sadhasivam, Senthilkumar 2014. ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics, 15 10, 1297-309Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander A; Cantor, Alan; Korf, Bruce; Perentesis, John; Gutmann, David H; Schorry, Elizabeth; Packer, Roger; Fisher, Michael J 2014. Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatric blood & cancer, 61 6, 982-6Wiles, Jason R; Isemann, Barbara; Ward, Laura P; Vinks, Alexander A; Akinbi, Henry 2014. Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure. The Journal of pediatrics, 165 3, 440-6Chidambaran, Vidya; Sadhasivam, Senthilkumar; Diepstraten, Jeroen; Esslinger, Hope; Cox, Shareen; Schnell, Beverly M; Samuels, Paul; Inge, Thomas; Vinks, Alexander A; Knibbe, Catherijne A 2013. Evaluation of propofol anesthesia in morbidly obese children and adolescents. BMC anesthesiology, 13 , 8Diepstraten, J; Chidambaran, V; Sadhasivam, S; Blussé van Oud-Alblas, H J; Inge, T; van Ramshorst, B; van Dongen, E P A; Vinks, A A; Knibbe, C A J 2013. An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children. CPT: pharmacometrics & systems pharmacology, 2 9, e73Emoto, C; Fukuda, T; Cox, S; Christians, U; Vinks, A A 2013. Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. CPT: pharmacometrics & systems pharmacology, 2 7, e59Fukuda, Tsuyoshi; Chidambaran, Vidya; Mizuno, Tomoyuki; Venkatasubramanian, Raja; Ngamprasertwong, Pornswan; Olbrecht, Vanessa; Esslinger, Hope R; Vinks, Alexander A; Sadhasivam, Senthilkumar 2013. OCT1 genetic variants influence the pharmacokinetics of morphine in children. Pharmacogenomics, 14 10, 1141-51Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Adamson, Peter C 2013. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia, 54 1, 141-55Gottesman, Omri; Kuivaniemi, Helena; Tromp, Gerard; Faucett, W Andrew; Li, Rongling; Manolio, Teri A; Sanderson, Saskia C; Kannry, Joseph; Zinberg, Randi; Basford, Melissa A; Brilliant, Murray; Carey, David J; Chisholm, Rex L; Chute, Christopher G; Connolly, John J; Crosslin, David; Denny, Joshua C; Gallego, Carlos J; Haines, Jonathan L; Hakonarson, Hakon; Harley, John; Jarvik, Gail P; Kohane, Isaac; Kullo, Iftikhar J; Larson, Eric B; McCarty, Catherine; Ritchie, Marylyn D; Roden, Dan M; Smith, Maureen E; Böttinger, Erwin P; Williams, Marc S 2013. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in medicine : official journal of the American College of Medical Genetics, 15 10, 761-71Hahn, Andrea; Vinks, Alexander A 2013. Lower vancomycin serum trough concentrations might not be the answer. The Pediatric infectious disease journal, 32 12, 1403-4Pian, Phillip; Labovitz, Edward; Hoffman, Keith; Clavijo, Claudia F; Rzasa Lynn, Rachael; Galinkin, Jeffrey L; Vinks, Alexander A; Malik, Punam; Christians, Uwe 2013. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 937 , 79-83Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2013. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1. Therapeutic drug monitoring, 35 3, 332-7Vinks, A A 2013. The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women. CPT: pharmacometrics & systems pharmacology, 2 3, e33Wang, Chenguang; Sadhavisvam, Senthilkumar; Krekels, Elke H J; Dahan, Albert; Tibboel, Dick; Danhof, Meindert; Vinks, Alexander A; Knibbe, Catherijne A J 2013. Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model. Clinical drug investigation, 33 7, 523-34Abdel-Rahman, Susan M; Amidon, Gordon L; Kaul, Ajay; Lukacova, Viera; Vinks, Alexander A; Knipp, Gregory T 2012. Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group. Clinical therapeutics, 34 11, S11-24Cattaneo, Dario; Vinks, Alexander A 2012. Optimizing immunosuppressive drug dosing in pediatric renal transplantation. Part of a special series on Paediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni. Pharmacological research, 65 2, 163-7Chidambaran, Vidya; Ngamprasertwong, Pornswan; Vinks, Alexander A; Sadhasivam, Senthilkumar 2012. Pharmacogenetics and anesthetic drugs. Current clinical pharmacology, 7 2, 78-101Cohen, Mindy; Sadhasivam, Senthilkumar; Vinks, Alexander A 2012. Pharmacogenetics in perioperative medicine. Current opinion in anaesthesiology, 25 4, 419-27Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size. Clinical pharmacokinetics, 51 8, 543-551Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol clearance in morbidly obese children and adolescents: influence of age and body size. Clinical pharmacokinetics, 51 8, 543-51Fukuda, Tsuyoshi; Goebel, Jens; Cox, Shareen; Maseck, Denise; Zhang, Kejian; Sherbotie, Joseph R; Ellis, Eileen N; James, Laura P; Ward, Robert M; Vinks, Alexander A 2012. UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients. Therapeutic drug monitoring, 34 6, 671-679Hooper, David K; Fukuda, Tsuyoshi; Gardiner, Rhonda; Logan, Barbara; Roy-Chaudhury, Ashwini; Kirby, Cassie L; Vinks, Alexander A; Goebel, Jens 2012. Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation. Transplantation, 93 8, 806-12Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne 2012. Update in Fetal Anesthesia for the Ex Utero Intrapartum Treatment (EXIT) Procedure. International anesthesiology clinics, 50 4, 26-40Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Brunner, Hermine I; Vinks, Alexander A 2012. Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. British journal of clinical pharmacology, 73 5, 727-40Sherwin, Catherine M T; Saldaña, Shannon N; Bies, Robert R; Aman, Michael G; Vinks, Alexander A 2012. Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents. Therapeutic drug monitoring, 34 5, 535-44Wiles, Jason R; Vinks, Alexander A; Akinbi, Henry 2012. Federal Legislation and the Advancement of Neonatal Drug Studies. The Journal of pediatrics, , Brandhorst, Gunnar; Oellerich, Michael; Brunet, Mercè; Kowalski, Richard; Vinks, Alexander; Wallemacq, Pierre 2011. Individually tailored immunosuppression: is there a role for biomarkers? Clinical chemistry, 57 3, 376-81Fukuda, Tsuyoshi; Brunner, Hermine I; Sagcal-Gironella, Anna Carmela P; Vinks, Alexander A 2011. Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Therapeutic drug monitoring, 33 5, 658-62Fukuda, Tsuyoshi; Goebel, Jens; Thøgersen, Håvard; Maseck, Denise; Cox, Shareen; Logan, Barbara; Sherbotie, Joseph; Seikaly, Mouin; Vinks, Alexander A 2011. Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients. Journal of clinical pharmacology, 51 3, 309-20Li, Zhiping; Wang, Li; Wang, Yi; Gui, Yonghao H; Vinks, Alexander A; MacLeod, Stuart 2011. Better medicines for 300 million children in China: report on recent progress. Paediatric drugs, 13 3, 137-40Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M; Meinzen-Derr, Jareen; Shi, Jing; Balmakund, Tonya; Vinks, Alexander A 2011. Pharmacokinetics of levetiracetam in neonates with seizures. The Journal of pediatrics, 159 1, 152-154.e3Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina; Cox, Shareen; Nelson, Shannen; Dina, Blair; Sherwin, Catherine M T; Klein-Gitelman, Marisa S; Vinks, Alexander A; Brunner, Hermine I 2011. Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus. Seminars in arthritis and rheumatism, 40 4, 307-13Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G; Rieder, Michael J; Brunner, Hermine I; Vinks, Alexander A 2011. Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study. Clinical therapeutics, 33 10, 1524-36Saldaña, Shannon N; Hooper, David K; Froehlich, Tanya E; Campbell, Kathleen M; Prows, Cynthia A; Sadhasivam, Senthilkumar; Nick, Todd G; Seid, Michael; Vinks, Alexander A; Glauser, Tracy A 2011. Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies. Clinical therapeutics, 33 12, 2072-81Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer; Spigarelli, Michael G; Vinks, Alexander A 2011. Optimal study design for pioglitazone in septic pediatric patients. Journal of pharmacokinetics and pharmacodynamics, 38 4, 433-47Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I; Goebel, Jens; Vinks, Alexander A 2011. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clinical pharmacokinetics, 50 1, 1-24Tett, Susan E; Saint-Marcoux, Franck; Staatz, Christine E; Brunet, Merce; Vinks, Alexander A; Miura, Masatomo; Marquet, Pierre; Kuypers, Dirk R; van Gelder, Teun; Cattaneo, Dario 2011. Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure. Transplantation reviews (Orlando, Fla.), 25 2, 47-57Tönshoff, Burkhard; David-Neto, Elias; Ettenger, Robert; Filler, Guido; van Gelder, Teun; Goebel, Jens; Kuypers, Dirk R J; Tsai, Eileen; Vinks, Alexander A; Weber, Lutz T; Zimmerhackl, Lothar Bernd 2011. Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation. Transplantation reviews (Orlando, Fla.), 25 2, 78-89Vinks, Alexander A 2011. Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics. The Journal of pediatrics, 159 3, 361-3Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Capparelli, Edmund V; Adamson, Peter C 2010. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. The New England journal of medicine, 362 9, 790-9Kuypers, Dirk R J; Le Meur, Yannick; Cantarovich, Marcelo; Tredger, Michael J; Tett, Susan E; Cattaneo, Dario; Tönshoff, Burkhard; Holt, David W; Chapman, Jeremy; Gelder, Teun van 2010. Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation. Clinical journal of the American Society of Nephrology : CJASN, 5 2, 341-58Mehta, Parinda A; Vinks, Alexander A; Filipovich, Alexandra; Bleesing, Jack; Jodele, Sonata; Jordan, Michael B; Marsh, Rebecca; Tarin, Richard; Edwards, Stephanie; Fearing, Deborah; Lawrence, Julia; Davies, Stella M 2010. Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 16 10, 1458-62Soldin, Offie P; Soldin, Steven J; Vinks, Alexander A; Younis, Islam; Landy, Helain J 2010. Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study. Therapeutic drug monitoring, 32 6, 767-73Vargus-Adams, Jilda N; McMahon, Mary A; Michaud, Linda J; Bean, Judy; Vinks, Alexander A 2010. Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique. PM & R : the journal of injury, function, and rehabilitation, 2 1, 37-42Mouksassi, M S; Marier, J F; Cyran, J; Vinks, A A 2009. Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome. Clinical pharmacology and therapeutics, 86 6, 667-71Pestian, John; Spencer, Malik; Matykiewicz, Pawel; Zhang, Kejian; Vinks, Alexander A; Glauser, Tracy 2009. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomedical informatics insights, 2 , 19-29Prausa, S E; Fukuda, T; Maseck, D; Curtsinger, K L; Liu, C; Zhang, K; Nick, T G; Sherbotie, J R; Ellis, E N; Goebel, J; Vinks, A A 2009. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clinical pharmacology and therapeutics, 85 5, 495-500Prows, Cynthia A; Nick, Todd G; Saldaña, Shannon N; Pathak, Sanjeev; Liu, Chunyan; Zhang, Kejian; Daniels, Zachary S; Vinks, Alexander A; Glauser, Tracy A 2009. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. Journal of child and adolescent psychopharmacology, 19 4, 385-94Thompson, Patrick A; Allen, Carl E; Horton, Terzah; Jones, Jeremy Y; Vinks, Alexander A; McClain, Kenneth L 2009. Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 52 5, 621-5Aman, Michael G; Vinks, Alexander A; Remmerie, Bart; Mannaert, Erik; Ramadan, Yaser; Masty, Jessica; Lindsay, Ronald L; Malone, Krista 2007. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clinical therapeutics, 29 7, 1476-86Cabovska, B; Cox, S L; Vinks, A A 2007. Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 852 1-2, 497-504Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2007. Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo. Antimicrobial agents and chemotherapy, 51 9, 3449-51Mouton, Johan W; Vinks, Alexander A 2007. Continuous infusion of beta-lactams. Current opinion in critical care, 13 5, 598-606Syed, Azeem; Vinks, Alexander A; Zakowski, Jack 2007. Trend in therapeutic monitoring of immunosuppressive drugs. MLO: medical laboratory observer, 39 7, 31-2Vinks, Alexander A; van Rossem, Ronald N; Mathôt, Ron A A; Heijerman, Harry G M; Mouton, Johan W 2007. Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation. Antimicrobial agents and chemotherapy, 51 9, 3049-55Weimert, Nicole A; Derotte, Maurits; Alloway, Rita R; Woodle, E Steve; Vinks, Alexander A 2007. Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications. Therapeutic drug monitoring, 29 2, 141-9Jiang, Zhengwen; Dragin, Nadine; Jorge-Nebert, Lucia F; Martin, Martha V; Guengerich, F Peter; Aklillu, Eleni; Ingelman-Sundberg, Magnus; Hammons, George J; Lyn-Cook, Beverly D; Kadlubar, Fred F; Saldana, Shannon N; Sorter, Michael; Vinks, Alexander A; Nassr, Nassr; von Richter, Oliver; Jin, Li; Nebert, Daniel W 2006. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenetics and genomics, 16 5, 359-67Mehta, Parinda; Vinks, Alexander; Filipovich, Alexandra; Vaughn, Gretchen; Fearing, Deborah; Sper, Christine; Davies, Stella 2006. High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 2, 235-40Carlsson, Kristin Cecilie; Hoem, Nils Ove; Glauser, Tracy; Vinks, Alexander A 2005. Development of a population pharmacokinetic model for carbamazepine based on sparse therapeutic monitoring data from pediatric patients with epilepsy. Clinical therapeutics, 27 5, 618-26de Wildt, Saskia N; de Hoog, Matthijs; Vinks, Alexander A; Joosten, Koen F M; van Dijk, Monique; van den Anker, John N 2005. Pharmacodynamics of midazolam in pediatric intensive care patients. Therapeutic drug monitoring, 27 1, 98-102Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2005. A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit. Clinical therapeutics, 27 6, 762-72Mouton, Johan W; Vinks, Alexander A 2005. Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations. Clinical pharmacokinetics, 44 7, 767-8Mouton, Johan W; Vinks, Alexander A 2005. Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration. Clinical pharmacokinetics, 44 2, 201-10Touw, D J; Neef, C; Thomson, A H; Vinks, A A 2005. Cost-effectiveness of therapeutic drug monitoring: a systematic review. Therapeutic drug monitoring, 27 1, 10-7Bos, A M E; Boom, K; Vinks, A A; Boezen, H M; Wanders, J; Dombernovsky, P; Aamdal, S; de Vries, E G E; Uges, D R A 2004. Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755. Cancer chemotherapy and pharmacology, 54 1, 64-70de Wildt, S N; de Hoog, M; Vinks, A A; van der Giesen, E; van den Anker, J N 2003. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Critical care medicine, 31 7, 1952-8Sallee, Floyd R; Gilbert, Donald L; Vinks, Alexander A; Miceli, Jeffrey J; Robarge, Lisa; Wilner, Keith 2003. Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission. Journal of the American Academy of Child and Adolescent Psychiatry, 42 8, 902-7Vinks, Alexander A; Den Hollander, Jan G; Overbeek, Shelley E; Jelliffe, Roger W; Mouton, Johan W 2003. Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis. Antimicrobial agents and chemotherapy, 47 2, 541-7de Hoog, Matthijs; Schoemaker, Rik C; van den Anker, John N; Vinks, Alexander A 2002. NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates. Therapeutic drug monitoring, 24 3, 359-65Le Brun, P P H; de Boer, A H; Mannes, G P M; de Fraîture, D M I; Brimicombe, R W; Touw, D J; Vinks, A A; Frijlink, H W; Heijerman, H G M 2002. Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 54 1, 25-32Vinks, Alexander A 2002. The application of population pharmacokinetic modeling to individualized antibiotic therapy. International journal of antimicrobial agents, 19 4, 313-22Beringer, P M; Vinks, A A; Jelliffe, R W; Shapiro, B J 2000. Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration. Antimicrobial agents and chemotherapy, 44 4, 809-13Le Brun, P P; de Graaf, A I; Vinks, A A 2000. High-performance liquid chromatographic method for the determination of colistin in serum. Therapeutic drug monitoring, 22 5, 589-93Mouton, J W; Touzw, D J; Horrevorts, A M; Vinks, A A 2000. Comparative pharmacokinetics of the carbapenems: clinical implications. Clinical pharmacokinetics, 39 3, 185-201Natsch, S; Vinks, M H; Voogt, A K; Mees, E B; Meyboom, R H 2000. Anaphylactic reactions to proton-pump inhibitors. The Annals of pharmacotherapy, 34 4, 474-6Ververs, T F; van Dijk, A; Vinks, S A; Blankestijn, P J; Savelkoul, J F; Meulenbelt, J; Boereboom, F T 2000. Pharmacokinetics and dosing regimen of meropenem in critically ill patients receiving continuous venovenous hemofiltration. Critical care medicine, 28 10, 3412-6Le Brun, P P; Vinks, A A; Touw, D J; Hekelaar, N; Mannes, G P; Brimicombe, R W; Frijlink, E H; Heijerman, H G 1999. Can tobramycin inhalation be improved with a jet nebulizer? Therapeutic drug monitoring, 21 6, 618-24Morris, R G; Sallustio, B C; Vinks, A A; LeGatt, D F; Verjee, Z H; El Desoky, E 1999. Some international approaches to aminoglycoside monitoring in the extended dosing interval era. Therapeutic drug monitoring, 21 4, 379-88van Lent-Evers, N A; Mathôt, R A; Geus, W P; van Hout, B A; Vinks, A A 1999. Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis. Therapeutic drug monitoring, 21 1, 63-73Beringer, P M; Vinks, A A; Jelliffe, R W 1998. Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis. The Journal of antimicrobial chemotherapy, 41 1, 142-4Touw, D J; Vinks, A A; Mouton, J W; Horrevorts, A M 1998. Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions. Clinical pharmacokinetics, 35 6, 437-59Visser, L; Stricker, B; Hoogendoorn, M; Vinks, A 1998. Do not give paraffin to packers. Lancet (London, England), 352 9137, 1352Meyboom, R H; van Puijenbroek, E P; Vinks, M H; Lastdrager, C J 1997. Disturbance of withdrawal bleeding during concomitant use of itraconazole and oral contraceptives. The New Zealand medical journal, 110 1049, 300Mouton, J W; Vinks, A A; Punt, N C 1997. Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrobial agents and chemotherapy, 41 4, 733-8Touw, D J; Vinks, A A; Neef, C 1997. Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm. Pharmacy world & science : PWS, 19 3, 142-51Vinks, A A; Brimicombe, R W; Heijerman, H G; Bakker, W 1997. Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics. The Journal of antimicrobial chemotherapy, 40 1, 125-33Mouton, J W; Vinks, A A 1996. Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations. The Journal of antimicrobial chemotherapy, 38 1, 5-15Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1996. Prospective evaluation of a dose prediction algorithm for intravenous tobramycin in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 2, 118-23Town, D J; Vinks, A A; Jacobs, F; Heijerman, H G; Bakker, W 1996. Creatinine clearance as predictor of tobramycin elimination in adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 5, 562-9Vinks, A A; Mouton, J W; Touw, D J; Heijerman, H G; Danhof, M; Bakker, W 1996. Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategy. Antimicrobial agents and chemotherapy, 40 5, 1091-7Vinks, A A; Touw, D J; van Rossen, R C; Heijerman, H G; Bakker, W 1996. Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT). Pharmacy world & science : PWS, 18 2, 74-7Touw, D J; Vinks, A A; Heijerman, H G; Hermans, J; Bakker, W 1994. Suggestions for the optimization of the initial tobramycin dose in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 16 2, 125-31Vinks, A A; Touw, D J; Heijerman, H G; Danhof, M; de Leede, G P; Bakker, W 1994. Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home. Therapeutic drug monitoring, 16 4, 341-8Bakker, W; Vinks, A A; Mouton, J W; de Jonge, P; Verzijl, J G; Heijerman, H G 1993. [Continuous intravenous home treatment of airway infections using ceftazidime administration via portable pump in patients with cystic fibrosis; a multicenter study]. Nederlands tijdschrift voor geneeskunde, 137 48, 2486-91Geus, W P; Vinks, A A; Smith, S J; Westra, P; Lamers, C B 1993. Comparison of two intravenous ranitidine regimens in a homogeneous population of intensive care unit patients. Alimentary pharmacology & therapeutics, 7 4, 451-7Mouton, J W; Vinks, A A 1993. [Antimicrobial treatment using beta-lactam antibiotics: continuous infusion appears to be sensible]. Nederlands tijdschrift voor geneeskunde, 137 48, 2476-80Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1993. Validation of tobramycin monitoring in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 15 1, 52-9Vinks, S A; Heijerman, H G; de Jonge, P; Bakker, W 1993. Photosensitivity due to ambulatory intravenous ceftazidime in cystic fibrosis patient. Lancet (London, England), 341 8854, 1221-2Geus, W P; Vinks, A A; Lamers, C B 1992. Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration. Scandinavian journal of gastroenterology. Supplement, 194 , 55-8Melissant, C F; Vinks, A A; Sleeboom, H P 1992. [Coma due to an overdose of valnoctamide]. Nederlands tijdschrift voor geneeskunde, 136 16, 793-4Hoogslag, P A; van Dijk, B; Vinks, A A 1989. [Respiratory depression following controlled-release morphine sulfate tablets]. Nederlands tijdschrift voor geneeskunde, 133 10, 516-7Keukens, F; van Voorst Vader, P C; Panders, A K; Vinks, S; Oosterhuis, J W; Kleijer, W J 1989. Xeroderma pigmentosum: squamous cell carcinoma of the tongue. Acta dermato-venereologica, 69 6, 530-1Inaba, T; Vinks, A; Otton, S V 1986. A simple borohydride/GC method for measuring sparteine metabolites in man. British journal of clinical pharmacology, 21 5, 473-80Van der Graaff, M; Vermeulen, N P; Vinks, M H; Breimer, D D 1986. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European journal of drug metabolism and pharmacokinetics, 11 2, 107-11Inaba, T; Vinks, A; Otton, S V; Kalow, W 1983. Comparative pharmacogenetics of sparteine and debrisoquine. Clinical pharmacology and therapeutics, 33 3, 394-9Slee, G L; Vinks, J A 1983. [Ileus following the use of loperamide (Imodium)]. Nederlands tijdschrift voor geneeskunde, 127 40, 1821-2Vinks, A; Inaba, T; Otton, S V; Kalow, W 1982. Sparteine metabolism in Canadian Caucasians. Clinical pharmacology and therapeutics, 31 1, 23-9Rogers, Christin C; Alloway, Rita R; Alexander, J Wesley; Cardi, Michael; Trofe, Jennifer; Vinks, Alexander A . Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study. Clinical transplantation, 22 3, 281-91Sadhasivam, Senthilkumar; Krekels, Elke H J; Chidambaran, Vidya; Esslinger, Hope R; Ngamprasertwong, Pornswan; Zhang, Kejian; Fukuda, Tsuyoshi; Vinks, Alexander A . Morphine clearance in children: does race or genetics matter? Journal of opioid management, 8 4, 217-26Williams, Michael T; Brown, Carrie A; Skelton, Matthew R; Vinks, Alexander A; Vorhees, Charles V . Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats. Neurotoxicology and teratology, 26 6, 849-56
Peer Reviewed Publications Cervantes, Francisco C; Mizuno, Tomoyuki; Dong, Min; Tang, Peter; Arbough, Trent; Vinks, Alexander A; Kaplan, Jennifer M; Tang Girdwood, Sonya C 2023. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic drug monitoring, 45 6, 832-836Choi, Yewon; Vinks, Alexander A; van der Graaf, Piet H 2023. Novel Therapeutic Modalities: The Future is Now. Clinical pharmacology and therapeutics, 114 3, 493-496Dong, Min; Ware, Russell E; Dallmann, André; Vinks, Alexander A 2023. Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps. Pharmacotherapy, 43 5, 419-429Jodele, Sonata; Mizuno, Kana; Sabulski, Anthony; Vinks, Alexander A 2023. Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies. Clinical pharmacology and therapeutics, 114 3, 511-514McIntire, Carter; Luna Torres, Julie; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Tang Girdwood, Sonya 2023. Piperacillin Pharmacokinetics and Pharmacodynamics in Paediatric Patients Who Received High Frequency Intra-Operative Piperacillin/Tazobactam Dosing. International journal of antimicrobial agents, 63 3, 107079Mizuno, Kana; Capparelli, Edmund V; Fukuda, Tsuyoshi; Dong, Min; Adamson, Peter C; Blumer, Jeffery L; Cnaan, Avital; Clark, Peggy O; Reed, Michael D; Shinnar, Shlomo; Vinks, Alexander A; Glauser, Tracy A 2023. Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Clinical pharmacology and therapeutics, 114 2, 459-469Pavia, Kathryn; Hambrick, H Rhodes; Paice, Kelli; Tang, Peter; Punt, Nieko; Kaplan, Jennifer; Goldstein, Stuart L; Vinks, Alexander A; Mizuno, Tomoyuki; Tang Girdwood, Sonya 2023. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. The Journal of antimicrobial chemotherapy, 78 9, 2140-2147Poweleit, Ethan A; Vinks, Alexander A; Mizuno, Tomoyuki 2023. Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic drug monitoring, , Power-Hays, Alexandra; Dong, Min; Punt, Nieko; Mizuno, Tomoyuki; Smart, Luke R; Vinks, Alexander A; Ware, Russell E 2023. Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical pharmacology and therapeutics, , Ramsey, Laura B; Prows, Cynthia A; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Quinn, Charles T; Teusink-Cross, Ashley; Girdwood, Sonya Tang; Dawson, D Brian; Vinks, Alexander A; Glauser, Tracy A 2023. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, , Smart, Luke R; Charles, Mwesige; McElhinney, Kathryn E; Dong, Min; Power-Hays, Alexandra; Howard, Thad; Vinks, Alexander A; Ambrose, Emmanuela E; Ware, Russell E 2023. Hydroxyurea pharmacokinetics and precision dosing in low-resource settings. Frontiers in molecular biosciences, 10 , 1130206Tang Girdwood, Sonya; Hasson, Denise; Caldwell, J Timothy; Slagle, Cara; Dong, Shun; Fei, Lin; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Goldstein, Stuart L 2023. Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury. The Journal of antimicrobial chemotherapy, 78 2, 478-487Tang Girdwood, Sonya; Tang, Peter; Fenchel, Matthew; Dong, Min; Stoneman, Erin; Jones, Rhonda; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Diseroad, Emily; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2023. Pharmacokinetic Parameters over Time during Sepsis and the Association of Target Attainment and Outcomes in Critically Ill Children and Young Adults Receiving Ceftriaxone. Pharmacotherapy, , Taylor, Zachary L; Poweleit, Ethan A; Paice, Kelli; Somers, Katherine M; Pavia, Kathryn; Vinks, Alexander A; Punt, Nieko; Mizuno, Tomoyuki; Girdwood, Sonya Tang 2023. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: pharmacometrics & systems pharmacology, 12 12, 1827-1845Chandra, Sharat; Mizuno, Kana; Zhao, Junfang; Davies, Stella M; Marsh, Rebecca A; Fukuda, Tsuyoshi; Setchell, Kenneth D R; Vinks, Alexander A; Mehta, Parinda A 2022. Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders. British journal of clinical pharmacology, 88 1, 115-127Colman, Ruben J; Mizuno, Tomoyuki; Fukushima, Keizo; Haslam, David B; Hyams, Jeffrey S; Boyle, Brendan; Noe, Joshua D; D'Haens, Geert R; Van Limbergen, Johan; Chun, Kelly; Yang, Jane; Denson, Lee A; Ollberding, Nicholas J; Vinks, Alexander A; Minar, Phillip 2022. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary pharmacology & therapeutics, , Colman, Ruben J; Samuels, Abigail; Mizuno, Tomoyuki; Punt, Nieko; Vinks, Alexander A; Minar, Phillip 2022. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases, , Colman, Ruben J; Xiong, Ye; Mizuno, Tomoyuki; Hyams, Jeffrey S; Noe, Joshua D; Boyle, Brendan; D'Haens, Geert R; van Limbergen, Johan; Chun, Kelly; Yang, Jane; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2022. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary pharmacology & therapeutics, 55 5, 593-603Dong, Min; Emoto, Chie; Fukuda, Tsuyoshi; Arnold, Danielle E; Mehta, Parinda A; Marsh, Rebecca A; Vinks, Alexander A 2022. Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation. British journal of clinical pharmacology, 88 1, 248-259Miyagawa, Bradley; Lazear, Danielle; Hooper, David K; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Model-informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient with Posterior Reversible Encephalopathy Syndrome. Therapeutic drug monitoring, , Mizuno, Kana; Dandoy, Christopher E; Teusink-Cross, Ashley; Davies, Stella M; Vinks, Alexander A; Jodele, Sonata 2022. Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT. Blood advances, 6 5, 1454-1463Mizuno, Tomoyuki; Dong, Min; Taylor, Zachary L; Ramsey, Laura B; Vinks, Alexander A 2022. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British journal of clinical pharmacology, 88 4, 1418-1426Tang Girdwood, Sonya; Dong, Min; Tang, Peter; Stoneman, Erin; Jones, Rhonda; Yunger, Toni; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Lahni, Patrick; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2022. Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment. Antimicrobial agents and chemotherapy, 66 1, e0142721Tang Girdwood, Sonya; Pavia, Kathryn; Paice, Kelli; Hambrick, H Rhodes; Kaplan, Jennifer; Vinks, Alexander A 2022. β-lactam precision dosing in critically ill children: Current state and knowledge gaps. Frontiers in pharmacology, 13 , 1044683van Hoogdalem, Matthijs W; Johnson, Trevor N; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott L; Ward, Laura P; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical pharmacology and therapeutics, 111 2, 496-508van Hoogdalem, Matthijs W; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology & therapeutics, 234 , 108045Whaley, Kaitlin G; Xiong, Ye; Karns, Rebekah; Hyams, Jeffrey S; Kugathasan, Subra; Boyle, Brendan M; Walters, Thomas D; Kelsen, Judith; LeLeiko, Neal; Shapiro, Jason; Waddell, Amanda; Fox, Sejal; Bezold, Ramona; Bruns, Stephanie; Widing, Robin; Haberman, Yael; Collins, Margaret H; Mizuno, Tomoyuki; Minar, Phillip; D'Haens, Geert R; Denson, Lee A; Vinks, Alexander A; Rosen, Michael J 2022. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, , Yi, Jae-Sung; Perla, Sravan; Huang, Yan; Mizuno, Kana; Giordano, Frank J; Vinks, Alexander A; Bennett, Anton M 2022. Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. Cardiovascular drugs and therapy, 36 4, 589-604Arnold, Danielle E; Emoto, Chie; Fukuda, Tsuyoshi; Dong, Min; Vinks, Alexander A; Lane, Adam; McIntosh, Kelly; Neumeier, Lisa; Lankester, Arjan C; Achini, Federica; Teusink-Cross, Ashley; Chandra, Sharat; Jordan, Michael B; Nelson, Adam S; Myers, Kasiani C; Davies, Stella M; Mehta, Parinda A; Marsh, Rebecca A 2021. A prospective pilot study of a novel alemtuzumab target concentration intervention strategy. Bone marrow transplantation, 56 12, 3029-3031Barrett, Jeffrey S; Barrett, Ryan F; Vinks, Alexander A 2021. Status Toward the Implementation of Precision Dosing in Children. Journal of clinical pharmacology, 61 Suppl 1 , S36-S51Bergan, Stein; Brunet, Mercè; Hesselink, Dennis A; Johnson-Davis, Kamisha L; Kunicki, Paweł K; Lemaitre, Florian; Marquet, Pierre; Molinaro, Mariadelfina; Noceti, Ofelia; Pattanaik, Smita; Pawinski, Tomasz; Seger, Christoph; Shipkova, Maria; Swen, Jesse J; van Gelder, Teun; Venkataramanan, Raman; Wieland, Eberhard; Woillard, Jean-Baptiste; Zwart, Tom C; Barten, Markus J; Budde, Klemens; Dieterlen, Maja-Theresa; Elens, Laure; Haufroid, Vincent; Masuda, Satohiro; Millan, Olga; Mizuno, Tomoyuki; Moes, Dirk J A R; Oellerich, Michael; Picard, Nicolas; Salzmann, Linda; Tönshoff, Burkhard; van Schaik, Ron H N; Vethe, Nils Tore; Vinks, Alexander A; Wallemacq, Pierre; Åsberg, Anders; Langman, Loralie J 2021. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic drug monitoring, 43 2, 150-200Boucher, Alexander A; Dong, Min; Vinks, Alexander A; Marahatta, Anu; Howard, Thad A; Ware, Russell E; Nathan, Jaimie D; Abu-El-Haija, Maisam; Luchtman-Jones, Lori 2021. Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation. Journal of clinical pharmacology, 61 4, 547-554Dong, Min; Rodriguez, Anna V; Blankenship, Chelsea A; McPhail, Gary; Vinks, Alexander A; Hunter, Lisa L 2021. Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis. The Journal of antimicrobial chemotherapy, 76 11, 2923-2931Girdwood, Sonya Tang; Kaplan, Jennifer; Vinks, Alexander A 2021. Methodologic Progress Note: Opportunistic Sampling for Pharmacology Studies in Hospitalized Children. Journal of hospital medicine, 16 1, 35-37Karkoska, Kristine; Quinn, Charles T; Niss, Omar; Pfeiffer, Amanda; Dong, Min; Vinks, Alexander A; McGann, Patrick T 2021. Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia. American journal of hematology, 96 5, 538-544McPhail, Brooks T; Emoto, Chie; Butler, Dawn; Fukuda, Tsuyoshi; Akinbi, Henry; Vinks, Alexander A 2021. Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches. Journal of clinical pharmacology, 61 7, 857-870Mizuno, Tomoyuki; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott; Ward, Laura; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A 2021. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clinical pharmacokinetics, 60 2, 249-259Neely, Michael N; Vinks, Alexander A 2021. Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing. Clinical pharmacology and therapeutics, 109 1, 22-24Peck, Richard W; Shahin, Mohamed H; Vinks, Alexander A 2021. Precision Dosing: The Clinical Pharmacology of Goldilocks. Clinical pharmacology and therapeutics, 109 1, 11-14Quinn, Charles T; Niss, Omar; Dong, Min; Pfeiffer, Amanda; Korpik, Jennifer; Reynaud, Mary; Bonar, Holly; Kalfa, Theodosia A; Smart, Luke R; Malik, Punam; Ware, Russell E; Vinks, Alexander A; McGann, Patrick T 2021. Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. British journal of haematology, 194 3, 617-625Sebold, Alison J; Day, Alyssa M; Ewen, Joshua; Adamek, Jack; Byars, Anna; Cohen, Bernard; Kossoff, Eric H; Mizuno, Tomoyuki; Ryan, Matthew; Sievers, Jacqueline; Smegal, Lindsay; Suskauer, Stacy J; Thomas, Cameron; Vinks, Alexander; Zabel, T Andrew; Hammill, Adrienne M; Comi, Anne M 2021. Sirolimus Treatment in Sturge-Weber Syndrome. Pediatric neurology, 115 , 29-40Soul, Janet S; Bergin, Ann M; Stopp, Christian; Hayes, Breda; Singh, Avantika; Fortuno, Carmen R; O'Reilly, Deirdre; Krishnamoorthy, Kalpathy; Jensen, Frances E; Rofeberg, Valerie; Dong, Min; Vinks, Alexander A; Wypij, David; Staley, Kevin J 2021. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Annals of neurology, 89 2, 327-340Tang Girdwood, Sonya C; Tang, Peter H; Murphy, Mark E; Chamberlain, Andrea R; Benken, Laura A; Jones, Rhonda L; Stoneman, Erin M; Kaplan, Jennifer M; Vinks, Alexander A 2021. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology, 61 4, 565-573Taylor, Zachary L; Thompson, Lauren E; Bear, Heather; Mizuno, Tomoyuki; Vinks, Alexander A; Ramsey, Laura B 2021. Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clinical and translational science, 14 6, 2267-2277van Gelder, Teun; Vinks, Alexander A 2021. Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing. Clinical pharmacology and therapeutics, 110 2, 273-276van Hoogdalem, Matthijs W; McPhail, Brooks T; Hahn, David; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2021. Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics. Expert opinion on drug metabolism & toxicology, 17 1, 87-103Vinks, Alexander A; Barrett, Jeffrey S 2021. Model-Informed Pediatric Drug Development: Application of Pharmacometrics to Define the Right Dose for Children. Journal of clinical pharmacology, 61 Suppl 1 , S52-S59Weiss, Brian D; Wolters, Pamela L; Plotkin, Scott R; Widemann, Brigitte C; Tonsgard, James H; Blakeley, Jaishri; Allen, Jeffrey C; Schorry, Elizabeth; Korf, Bruce; Robison, Nathan J; Goldman, Stewart; Vinks, Alexander A; Emoto, Chie; Fukuda, Tsuyoshi; Robinson, Coretta T; Cutter, Gary; Edwards, Lloyd; Dombi, Eva; Ratner, Nancy; Packer, Roger; Fisher, Michael J 2021. NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39 7, 797-806Wong, Steven H; Marquet, Pierre; Cattaneo, Dario; Svinarov, Dobrin; Bergan, Stein; Walson, Philip; Vinks, Alexander A; Shipkova, Maria 2021. Therapeutic Drug Monitoring in the Era of Precision Medicine: Achievements, Gaps, and Perspectives-An Interview in Honor of Professor Charles Pippenger. Therapeutic drug monitoring, 43 6, 719-727Wright, Karen D; Yao, Xiaopan; London, Wendy B; Kao, Pei-Chi; Gore, Lia; Hunger, Stephen; Geyer, Russ; Cohen, Kenneth J; Allen, Jeffrey C; Katzenstein, Howard M; Smith, Amy; Boklan, Jessica; Nazemi, Kellie; Trippett, Tanya; Karajannis, Matthias; Herzog, Cynthia; Destefano, Joseph; Direnzo, Jennifer; Pietrantonio, Jay; Greenspan, Lianne; Cassidy, Danielle; Schissel, Debra; Perentesis, John; Basu, Mitali; Mizuno, Tomoyuki; Vinks, Alexander A; Prabhu, Sanjay P; Chi, Susan N; Kieran, Mark W 2021. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma. Pediatric blood & cancer, 68 2, e28787Xiong, Ye; Mizuno, Tomoyuki; Colman, Ruben; Hyams, Jeffrey; Noe, Joshua D; Boyle, Brendan; Tsai, Yi-Ting; Dong, Min; Jackson, Kimberly; Punt, Nieko; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2021. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical pharmacology and therapeutics, 109 6, 1639-1647Zhao, Junfang; Sharat, Chandra; Mehta, Parinda A; Mizuno, Kana; Vinks, Alexander A; Setchell, Kenneth D R 2021. Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan. The journal of applied laboratory medicine, 6 3, 625-636Balyan, Rajiv; Dong, Min; Pilipenko, Valentina; Geisler, Kristie; Vinks, Alexander A; Chidambaran, Vidya 2020. Hydromorphone population pharmacokinetics in pediatric surgical patients. Paediatric anaesthesia, 30 10, 1091-1101Bauman, Laura E; Xiong, Ye; Mizuno, Tomoyuki; Minar, Philip; Fukuda, Tsuyoshi; Dong, Min; Rosen, Michael J; Vinks, Alexander A 2020. Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases, 26 3, 429-439Cazelles, Remi; Shukla, Rajendra P; Ware, Russell E; Vinks, Alexander A; Ben-Yoav, Hadar 2020. Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS2-Modified Electrodes and Chemometrics. Biomedicines, 9 1, Chen, Yewei; Sun, Li; Xu, Hong; Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A; Brunner, Hermine I; Li, Yifan; Li, Zhiping 2020. PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing. Frontiers in pharmacology, 11 , 605060Emoto, Chie; Hahn, David; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2020. Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates. Clinical pharmacology and therapeutics, 107 2, 319-320Euteneuer, Joshua C; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Zhao, Junfang; Setchell, Kenneth D R; Muglia, Louis J; Vinks, Alexander A 2020. Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants. Therapeutic drug monitoring, 42 5, 778-786Hahn, David; Fukuda, Tsuyoshi; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Sadhasivam, Senthilkumar; Emoto, Chie 2020. Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients. Journal of clinical pharmacology, 60 8, 992-998McPhail, Brooks T; Emoto, Chie; Fukuda, Tsuyoshi; Butler, Dawn; Wiles, Jason R; Akinbi, Henry; Vinks, Alexander A 2020. Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. Journal of clinical pharmacology, 60 4, 453-465Meier, Emily R; Creary, Susan E; Heeney, Matthew M; Dong, Min; Appiah-Kubi, Abena O; Nelson, Stephen C; Niss, Omar; Piccone, Connie; Quarmyne, Maa-Ohui; Quinn, Charles T; Saving, Kay L; Scott, John P; Talati, Ravi; Latham, Teresa S; Pfeiffer, Amanda; Shook, Lisa M; Vinks, Alexander A; Lane, Adam; McGann, Patrick T 2020. Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia. Trials, 21 1, 983Somberg, John C; Vinks, Alexander A; Dong, Min; Molnar, Janos 2020. Model-Informed Development of Sotalol Loading and Dose Escalation Employing an Intravenous Infusion. Cardiology research, 11 5, 294-304Tang Girdwood, Sonya; Arbough, Trent; Dong, Min; Mizuno, Tomoyuki; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer 2020. Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets. Pharmacotherapy, 40 10, 1061-1068Taylor, Zachary L; Mizuno, Tomoyuki; Punt, Nieko C; Baskaran, Balaji; Navarro Sainz, Adriana; Shuman, William; Felicelli, Nicholas; Vinks, Alexander A; Heldrup, Jesper; Ramsey, Laura B 2020. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical pharmacology and therapeutics, 108 3, 635-643Ullrich, Nicole J; Prabhu, Sanjay P; Reddy, Alyssa T; Fisher, Michael J; Packer, Roger; Goldman, Stewart; Robison, Nathan J; Gutmann, David H; Viskochil, David H; Allen, Jeffrey C; Korf, Bruce; Cantor, Alan; Cutter, Gary; Thomas, Coretta; Perentesis, John P; Mizuno, Tomoyuki; Vinks, Alexander A; Manley, Peter E; Chi, Susan N; Kieran, Mark W 2020. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro-oncology, 22 10, 1527-1535van Hoogdalem, Matthijs W; Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Mehta, Parinda A; Vinks, Alexander A 2020. Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients. British journal of clinical pharmacology, 86 5, 933-943Vinks, Alexander A; Peck, Richard W; Neely, Michael; Mould, Diane R 2020. Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs. Clinical pharmacology and therapeutics, 107 1, 129-135Vinks, Alexander A; Punt, Nieko C; Menke, Frank; Kirkendall, Eric; Butler, Dawn; Duggan, Thomas J; Cortezzo, DonnaMaria E; Kiger, Sam; Dietrich, Tom; Spencer, Paul; Keefer, Rob; Setchell, Kenneth D R; Zhao, Junfang; Euteneuer, Joshua C; Mizuno, Tomoyuki; Dufendach, Kevin R 2020. Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical pharmacology and therapeutics, 107 1, 186-194Ware, Russell E; Marahatta, Anu; Ware, Julie L; McElhinney, Kathryn; Dong, Min; Vinks, Alexander A 2020. Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS). The Journal of pediatrics, 222 , 236-239Boucher, Alexander A; Mizuno, Tomoyuki; Vinks, Alexander A; Goldstein, Stuart L; Tiao, Greg M; Geller, James I 2019. Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma. Pediatric blood & cancer, 66 1, e27425Brunet, Mercè; van Gelder, Teun; Åsberg, Anders; Haufroid, Vincent; Hesselink, Dennis A; Langman, Loralie; Lemaitre, Florian; Marquet, Pierre; Seger, Christoph; Shipkova, Maria; Vinks, Alexander; Wallemacq, Pierre; Wieland, Eberhard; Woillard, Jean Baptiste; Barten, Markus J; Budde, Klemens; Colom, Helena; Dieterlen, Maja-Theresa; Elens, Laure; Johnson-Davis, Kamisha L; Kunicki, Paweł K; MacPhee, Iain; Masuda, Satohiro; Mathew, Binu S; Millán, Olga; Mizuno, Tomoyuki; Moes, Dirk-Jan A R; Monchaud, Caroline; Noceti, Ofelia; Pawinski, Tomasz; Picard, Nicolas; van Schaik, Ron; Sommerer, Claudia; Vethe, Nils Tore; de Winter, Brenda; Christians, Uwe; Bergan, Stein 2019. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Therapeutic drug monitoring, 41 3, 261-307Emoto, Chie; Johnson, Trevor N; Hahn, David; Christians, Uwe; Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition. CPT: pharmacometrics & systems pharmacology, 8 5, 273-284Euteneuer, Joshua C; Kamatkar, Suyog; Fukuda, Tsuyoshi; Vinks, Alexander A; Akinbi, Henry T 2019. Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy. Journal of clinical pharmacology, 59 2, 168-176Hahn, David; Emoto, Chie; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study. Clinical pharmacology and therapeutics, 105 3, 761-768Leino, Abbie D; Emoto, Chie; Fukuda, Tsuyoshi; Privitera, Michael; Vinks, Alexander A; Alloway, Rita R 2019. Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 10, 2944-2948Leino, Abbie D; King, Eileen C; Jiang, Wenlei; Vinks, Alexander A; Klawitter, Jost; Christians, Uwe; Woodle, E Steve; Alloway, Rita R; Rohan, Jennifer M 2019. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 5, 1410-1420Lichvar, Alicia; Tremblay, Simon; Naik, Devanshi; Lipscomb, Jessi; King, Eileen; Vinks, Alexander A; Christians, Uwe; Alloway, Rita R 2019. Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients. Pharmacotherapy, 39 5, 564-575McGann, Patrick T; Niss, Omar; Dong, Min; Marahatta, Anu; Howard, Thad A; Mizuno, Tomoyuki; Lane, Adam; Kalfa, Theodosia A; Malik, Punam; Quinn, Charles T; Ware, Russell E; Vinks, Alexander A 2019. Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia. American journal of hematology, 94 8, 871-879Mehta, Parinda A; Emoto, Chie; Fukuda, Tsuyoshi; Seyboth, Brian; Teusink-Cross, Ashley; Davies, Stella M; Wilhelm, Jamie; Fuller, Kirsten; Vinks, Alexander A; Boulad, Farid 2019. Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different? Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 25 12, 2416-2421Mizuno, Tomoyuki; Gist, Katja M; Gao, Zhiqian; Wempe, Michael F; Alten, Jeffrey; Cooper, David S; Goldstein, Stuart L; Vinks, Alexander A 2019. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clinical pharmacokinetics, 58 6, 793-803Mizuno, Tomoyuki; O'Brien, Maureen M; Vinks, Alexander A 2019. Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128 , 209-214Ramsey, Laura B; Mizuno, Tomoyuki; Vinks, Alexander A; O'Brien, Maureen M 2019. Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib. Pediatric blood & cancer, 66 5, e27618Ramsey, Laura B; Prows, Cynthia A; Zhang, Kejian; Saldaña, Shannon N; Sorter, Michael T; Pestian, John P; Wenstrup, Richard J; Vinks, Alexander A; Glauser, Tracy A 2019. Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine. Clinical pharmacology and therapeutics, 105 1, 49-52Soul, Janet S; Pressler, Ronit; Allen, Marilee; Boylan, Geraldine; Rabe, Heike; Portman, Ron; Hardy, Pollyanna; Zohar, Sarah; Romero, Klaus; Tseng, Brian; Bhatt-Mehta, Varsha; Hahn, Cecil; Denne, Scott; Auvin, Stephane; Vinks, Alexander; Lantos, John; Marlow, Neil; Davis, Jonathan M 2019. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatric research, 85 7, 943-954Tang Girdwood, Sonya C; Mizuno, Tomoyuki; Krallman, Kelli A; Benken, Laura A; Stoneman, Erin M; Yunger, Toni M; Wong, Hector R; Vinks, Alexander A; Kaplan, Jennifer M 2019. Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children. The Pediatric infectious disease journal, 38 12, 1224-1227Vinks, Alexander A 2019. From Molecule to Patient and Ways to Get the Dose Precisely Right. Clinical pharmacology and therapeutics, 105 3, 534-537Berry, Susan A; Vockley, Jerry; Vinks, Alexander A; Dong, Min; Diaz, George A; McCandless, Shawn E; Smith, Wendy E; Harding, Cary O; Zori, Roberto; Ficicioglu, Can; Lichter-Konecki, Uta; Perdok, Renee; Robinson, Beth; Holt, Robert J; Longo, Nicola 2018. Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders. Molecular genetics and metabolism, 125 3, 251-257Chandra, Sharat; Fukuda, Tsuyoshi; Mizuno, Kana; Davies, Stella M; Teusink-Cross, Ashley; Tarin, Rich; Marsh, Rebecca A; Vinks, Alexander A; Mehta, Parinda A 2018. Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study. The Journal of antimicrobial chemotherapy, 73 6, 1651-1658Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2018. Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management. British journal of clinical pharmacology, 84 7, 1410-1412Emoto, Chie; Johnson, Trevor N; McPhail, Brooks T; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations. CPT: pharmacometrics & systems pharmacology, 7 4, 237-250Emoto, Chie; Johnson, Trevor N; Neuhoff, Sibylle; Hahn, David; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants. CPT: pharmacometrics & systems pharmacology, 7 7, 464-473Farag, Elmoubasher; Sikkema, Reina S; Vinks, Tinka; Islam, Md Mazharul; Nour, Mohamed; Al-Romaihi, Hamad; Al Thani, Mohammed; Atta, Muzzamil; Alhajri, Farhoud H; Al-Marri, Salih; AlHajri, Mohd; Reusken, Chantal; Koopmans, Marion 2018. Drivers of MERS-CoV Emergence in Qatar. Viruses, 11 1, Gist, Katja M; Cooper, David S; Wrona, Julia; Faubel, Sarah; Altmann, Christopher; Gao, Zhiqian; Marino, Bradley S; Alten, Jeffrey; Hock, Kristal M; Mizuno, Tomoyuki; Vinks, Alexander A; Joy, Melanie S; Wempe, Michael F; Bennett, Michael R; Goldstein, Stuart L 2018. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Therapeutic drug monitoring, 40 2, 186-194Kaplan, Jennifer M; Zingarelli, Basilia; Krallman, Kelli; Tang Girdwood, Sonya; Lagory, Denise; Mizuno, Tomoyuki; Fei, Lin; Wong, Hector R; Vinks, Alexander A 2018. Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial. Intensive care medicine, 44 11, 2006-2008Miller, J W; Balyan, R; Dong, M; Mahmoud, M; Lam, J E; Pratap, J N; Paquin, J R; Li, B L; Spaeth, J P; Vinks, A; Loepke, A W 2018. Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study. British journal of anaesthesia, 120 5, 1056-1065Mizuno, Kana; Dong, Min; Fukuda, Tsuyoshi; Chandra, Sharat; Mehta, Parinda A; McConnell, Scott; Anaissie, Elias J; Vinks, Alexander A 2018. Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation. Clinical pharmacokinetics, 57 5, 625-636Ramsey, Laura B; Balis, Frank M; O'Brien, Maureen M; Schmiegelow, Kjeld; Pauley, Jennifer L; Bleyer, Archie; Widemann, Brigitte C; Askenazi, David; Bergeron, Sharon; Shirali, Anushree; Schwartz, Stefan; Vinks, Alexander A; Heldrup, Jesper 2018. Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance. The oncologist, 23 1, 52-61Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; King, Eileen C; Zou, Yuanshu; Jiang, Wenlei; Woodle, E Steve; Tremblay, Simon; Klawitter, Jelena; Klawitter, Jost; Christians, Uwe 2017. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS medicine, 14 11, e1002428Balyan, Rajiv; Mecoli, Marc; Venkatasubramanian, Raja; Chidambaran, Vidya; Kamos, Nichole; Clay, Smokey; Moore, David L; Mavi, Jagroop; Glover, Chris D; Szmuk, Peter; Vinks, Alexander; Sadhasivam, Senthilkumar 2017. CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients. Pharmacogenomics, 18 4, 337-348Balyan, Rajiv; Zhang, Xue; Chidambaran, Vidya; Martin, Lisa J; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Vinks, Alexander A; Sadhasivam, Senthilkumar 2017. OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children. Pharmacogenomics, 18 7, 621-629Cabrera-Salcedo, Catalina; Mizuno, Tomoyuki; Tyzinski, Leah; Andrew, Melissa; Vinks, Alexander A; Frystyk, Jan; Wasserman, Halley; Gordon, Catherine M; Hwa, Vivian; Backeljauw, Philippe; Dauber, Andrew 2017. Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density. The Journal of clinical endocrinology and metabolism, 102 12, 4568-4577Chidambaran, V; Venkatasubramanian, R; Zhang, X; Martin, L J; Niu, J; Mizuno, T; Fukuda, T; Meller, J; Vinks, A A; Sadhasivam, S 2017. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. The pharmacogenomics journal, 17 2, 162-169Chidambaran, Vidya; Pilipenko, Valentina; Spruance, Kristie; Venkatasubramanian, Raja; Niu, Jing; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Zhang, Kejian; Kaufman, Kenneth; Vinks, Alexander A; Martin, Lisa J; Sadhasivam, Senthilkumar 2017. Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children. Pharmacogenomics, 18 2, 143-156Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; Reny, J-L; Marsousi, N; Daali, Y; Fairman, D; Cook, J; Lesko, L J; McCune, J S; Knibbe, Caj; de Wildt, S N; Leeder, J S; Neely, M; Zuppa, A F; Vicini, P; Aarons, L; Johnson, T N; Boiani, J; Rostami-Hodjegan, A 2017. Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clinical pharmacology and therapeutics, 101 5, 646-656Diwan, Tayyab S; Lichvar, Alicia B; Leino, Abbie D; Vinks, Alexander A; Christians, Uwe; Shields, Adele R; Cardi, Michael A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Kaiser, Tiffany; Woodle, E Steve; Alloway, Rita R 2017. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clinical transplantation, 31 6, Dong, Min; Fukuda, Tsuyoshi; Selim, Sally; Smith, Mark A; Rabinovich-Guilatt, Laura; Cassella, James V; Vinks, Alexander A 2017. Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents. Clinical pharmacokinetics, 56 10, 1207-1217Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A 2017. Opportunities for model-based precision dosing in the treatment of sickle cell anemia. Blood cells, molecules & diseases, 67 , 143-147Downes, Kevin J; Dong, Min; Fukuda, Tsuyoshi; Clancy, John P; Haffner, Christopher; Bennett, Michael R; Vinks, Alexander A; Goldstein, Stuart L 2017. Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis. The Journal of antimicrobial chemotherapy, 72 1, 254-260Emoto, C; Fukuda, T; Johnson, T N; Neuhoff, S; Sadhasivam, S; Vinks, A A 2017. Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter. CPT: pharmacometrics & systems pharmacology, 6 2, 110-119Faircloth, Jenna M; Miner, Kristin M; Alsaied, Tarek; Nelson, Nicole; Ciambarella, Julie; Mizuno, Tomoyuki; Palumbo, Joseph S; Vinks, Alexander A; Veldtman, Gruschen R 2017. Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients. Journal of thrombosis and thrombolysis, 44 1, 38-47Faircloth, Jenna M; Roe, Olivia; Alsaied, Tarek; Palumbo, Joseph S; Vinks, Alexander; Veldtman, Gruschen R 2017. Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations. Journal of thrombosis and thrombolysis, 44 3, 275-280Hahn, David; Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2017. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children. Drug metabolism and disposition: the biological fate of chemicals, 45 1, 23-26Marsh, Rebecca A; Fukuda, Tsuyoshi; Emoto, Chie; Neumeier, Lisa; Khandelwal, Pooja; Chandra, Sharat; Teusink-Cross, Ashley; Vinks, Alexander A; Mehta, Parinda A 2017. Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 23 4, 635-641Mizuno, Tomoyuki; Emoto, Chie; Fukuda, Tsuyoshi; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109S , S124-S131Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Christians, Uwe; Perentesis, John P; Fouladi, Maryam; Vinks, Alexander A 2017. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. British journal of clinical pharmacology, 83 5, 1097-1107Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Emoto, Chie; Mobberley-Schuman, Paula S; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatric blood & cancer, 64 8, Ramsey, L B; Mizuno, T; Vinks, A A; Margolis, P A 2017. Learning Health Systems as Facilitators of Precision Medicine. Clinical pharmacology and therapeutics, 101 3, 359-367Rohan, Jennifer M; Fukuda, Tsuyoshi; Alderfer, Melissa A; Wetherington Donewar, Crista; Ewing, Linda; Katz, Ernest R; Muriel, Anna C; Vinks, Alexander A; Drotar, Dennis 2017. Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation. Journal of pediatric psychology, 42 2, 232-244Selim, Sally; Riesenberg, Robert; Cassella, James; Kunta, Jeevan; Hellriegel, Edward; Smith, Mark A; Vinks, Alexander A; Rabinovich-Guilatt, Laura 2017. Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents. Journal of clinical pharmacology, 57 10, 1244-1257Varnell, Charles D; Fukuda, Tsuyoshi; Kirby, Cassie L; Martin, Lisa J; Warshaw, Barry L; Patel, Hiren P; Chand, Deepa H; Barletta, Gina-Marie; Van Why, Scott K; VanDeVoorde, Rene G; Weaver, Donald J; Wilson, Amy; Verghese, Priya S; Vinks, Alexander A; Greenbaum, Larry A; Goebel, Jens; Hooper, David K 2017. Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs. Pediatric transplantation, 21 7, Vinks, A A 2017. Precision Medicine-Nobody Is Average. Clinical pharmacology and therapeutics, 101 3, 304-307Xiong, Ye; Fukuda, Tsuyoshi; Knibbe, Catherijne A J; Vinks, Alexander A 2017. Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies. Pediatric clinics of North America, 64 6, 1417-1438Yu, Tian; Enioutina, Elena Y; Brunner, Hermine I; Vinks, Alexander A; Sherwin, Catherine M 2017. Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clinical pharmacokinetics, 56 2, 107-125Adams, Denise M; Trenor, Cameron C; Hammill, Adrienne M; Vinks, Alexander A; Patel, Manish N; Chaudry, Gulraiz; Wentzel, Mary Sue; Mobberley-Schuman, Paula S; Campbell, Lisa M; Brookbank, Christine; Gupta, Anita; Chute, Carol; Eile, Jennifer; McKenna, Jesse; Merrow, Arnold C; Fei, Lin; Hornung, Lindsey; Seid, Michael; Dasgupta, A Roshni; Dickie, Belinda H; Elluru, Ravindhra G; Lucky, Anne W; Weiss, Brian; Azizkhan, Richard G 2016. Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies. Pediatrics, 137 2, e20153257Arya, Ravindra; Gillespie, Catherine W; Cnaan, Avital; Devarajan, Mahima; Clark, Peggy; Shinnar, Shlomo; Vinks, Alexander A; Mizuno, Kana; Glauser, Tracy A 2016. Obesity and overweight as CAE comorbidities and differential drug response modifiers. Neurology, 86 17, 1613-21Cvijanovich, Natalie Z; King, Janet C; Flori, Heidi R; Gildengorin, Ginny; Vinks, Alexander A; Wong, Hector R 2016. Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness. JPEN. Journal of parenteral and enteral nutrition, 40 6, 860-8Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2016. Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia. British journal of clinical pharmacology, 81 4, 742-52Downes, Kevin J; Goldstein, Stuart L; Vinks, Alexander A 2016. Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe. Journal of the Pediatric Infectious Diseases Society, 5 1, 65-7Emoto, C; Fukuda, T; Mizuno, T; Schniedewind, B; Christians, Uwe; Adams, D M; Vinks, A A 2016. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 5 8, 411-7Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2016. Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. Therapeutic drug monitoring, 38 5, 607-13Gist, Katja M; Goldstein, Stuart L; Joy, Melanie S; Vinks, Alexander A 2016. Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review. Journal of cardiovascular pharmacology, 67 2, 175-81Hahn, Andrea; Fukuda, Tsuyoshi; Hahn, David; Mizuno, Tomoyuki; Frenck, Robert W; Vinks, Alexander A 2016. Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia. Pharmacogenomics, 17 6, 547-59Jodele, Sonata; Fukuda, Tsuyoshi; Mizuno, Kana; Vinks, Alexander A; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Chima, Ranjit S; Hirsch, Russel; Teusink, Ashley; Lazear, Danielle; Lane, Adam; Myers, Kasiani C; Dandoy, Christopher E; Davies, Stella M 2016. Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 2, 307-315Khandelwal, Pooja; Emoto, Chie; Fukuda, Tsuyoshi; Vinks, Alexander A; Neumeier, Lisa; Dandoy, Christopher E; El-Bietar, Javier; Chandra, Sharat; Davies, Stella M; Bleesing, Jacob J; Jordan, Michael B; Mehta, Parinda A; Jodele, Sonata; Grimley, Michael S; Kumar, Ashish; Myers, Kasiani C; Marsh, Rebecca A 2016. A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 12, 2220-2225Khandelwal, Pooja; Fukuda, Tsuyoshi; Mizuno, Kana; Teusink-Cross, Ashley; Mehta, Parinda A; Marsh, Rebecca A; Kashuba, Angela D M; Vinks, Alexander A; Davies, Stella M 2016. A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 10, 1829-1835Nehus, Edward J; Mizuno, Tomoyuki; Cox, Shareen; Goldstein, Stuart L; Vinks, Alexander A 2016. Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations. Journal of clinical pharmacology, 56 3, 291-7Ngamprasertwong, Pornswan; Dong, Min; Niu, Jing; Venkatasubramanian, Raja; Vinks, Alexander A; Sadhasivam, Senthilkumar 2016. Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model. PloS one, 11 1, e0146563Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2016. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum. Therapeutic drug monitoring, 38 2, 284Teusink, Ashley; Vinks, Alexander; Zhang, Kejian; Davies, Stella; Fukuda, Tsuyoshi; Lane, Adam; Nortman, Shannon; Kissell, Diane; Dell, Sarah; Filipovich, Alexandra; Mehta, Parinda 2016. Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 3, 482-6Vinks, Alexander A 2016. Therapeutic Optimization as Part of the Precision Medicine Paradigm. Clinical pharmacology and therapeutics, 99 4, 340-2Birdwell, K A; Decker, B; Barbarino, J M; Peterson, J F; Stein, C M; Sadee, W; Wang, D; Vinks, A A; He, Y; Swen, J J; Leeder, J S; van Schaik, Rhn; Thummel, K E; Klein, T E; Caudle, K E; MacPhee, I A M 2015. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical pharmacology and therapeutics, 98 1, 19-24Brouwer, K L R; Aleksunes, L M; Brandys, B; Giacoia, G P; Knipp, G; Lukacova, V; Meibohm, B; Nigam, S K; Rieder, M; de Wildt, S N 2015. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical pharmacology and therapeutics, 98 3, 266-87Chidambaran, Vidya; Venkatasubramanian, Raja; Sadhasivam, Senthilkumar; Esslinger, Hope; Cox, Shareen; Diepstraten, Jeroen; Fukuda, Tsuyoshi; Inge, Thomas; Knibbe, Catherijne A J; Vinks, Alexander A 2015. Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. Paediatric anaesthesia, 25 9, 911-923Christians, Uwe; Vinks, Alexander A; Langman, Loralie J; Clarke, William; Wallemacq, Pierre; van Gelder, Teun; Renjen, Varun; Marquet, Pierre; Meyer, Eric J 2015. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Therapeutic drug monitoring, 37 6, 718-24Emoto, C; Fukuda, T; Johnson, T N; Adams, D M; Vinks, A A 2015. Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 4 2, e17Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2015. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Therapeutic drug monitoring, 37 3, 395-9Emoto, Chie; Fukuda, Tsuyoshi; Venkatasubramanian, Raja; Vinks, Alexander A 2015. The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model. British journal of clinical pharmacology, 80 6, 1438-46Fouladi, Maryam; Perentesis, John P; Wagner, Lars M; Vinks, Alexander A; Reid, Joel M; Ahern, Charlotte; Thomas, George; Mercer, Carol A; Krueger, Darcy A; Houghton, Peter J; Doyle, L Austin; Chen, Helen; Weigel, Brenda; Blaney, Susan M 2015. A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 7, 1558-65Gist, Katja M; Mizuno, Tomoyuki; Goldstein, Stuart L; Vinks, Alexander 2015. Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury. Therapeutic drug monitoring, 37 6, 792-6Hahn, Andrea; Frenck, Robert W; Allen-Staat, Mary; Zou, Yuanshu; Vinks, Alexander A 2015. Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia. Therapeutic drug monitoring, 37 5, 619-25Hahn, Andrea; Frenck, Robert W; Zou, Yuanshu; Vinks, Alexander A 2015. Validation of a pediatric population pharmacokinetic model for vancomycin. Therapeutic drug monitoring, 37 3, 413-6Rosen, M J; Minar, P; Vinks, A A 2015. Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply. Alimentary pharmacology & therapeutics, 42 2, 241Rosen, M J; Minar, P; Vinks, A A 2015. Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis. Alimentary pharmacology & therapeutics, 41 11, 1094-103Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming; Clark, Peggy; Dlugos, Dennis; Hirtz, Deborah G; Masur, David; Mizrahi, Eli M; Moshé, Solomon L; Glauser, Tracy A 2015. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology, 85 13, 1108-14Shokati, Touraj; Bodenberger, Nicholas; Gadpaille, Holly; Schniedewind, Björn; Vinks, Alexander A; Jiang, Wenlei; Alloway, Rita R; Christians, Uwe 2015. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. Journal of visualized experiments : JoVE, 105, e52424Vinks, A A; Emoto, C; Fukuda, T 2015. Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children. Clinical pharmacology and therapeutics, 98 3, 298-308Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander; Cantor, Alan; Perentesis, John; Schorry, Elizabeth; Ullrich, Nicole; Gutmann, David H; Tonsgard, James; Viskochil, David; Korf, Bruce; Packer, Roger J; Fisher, Michael J 2015. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro-oncology, 17 4, 596-603Wiles, Jason R; Isemann, Barbara; Mizuno, Tomoyuki; Tabangin, Meredith E; Ward, Laura P; Akinbi, Henry; Vinks, Alexander A 2015. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. The Journal of pediatrics, 167 6, 1214-20.e3Yang, Xiaoyan; Sherwin, Catherine M T; Yu, Tian; Yellepeddi, Venkata K; Brunner, Hermine I; Vinks, Alexander A 2015. Pharmacokinetic modeling of therapies for systemic lupus erythematosus. Expert review of clinical pharmacology, 8 5, 587-603Dong, Min; Fukuda, Tsuyoshi; Cox, Shareen; de Vries, Marij T; Hooper, David K; Goebel, Jens; Vinks, Alexander A 2014. Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period. British journal of clinical pharmacology, 78 5, 1102-12Dong, Min; Fukuda, Tsuyoshi; Vinks, Alexander A 2014. Optimization of mycophenolic acid therapy using clinical pharmacometrics. Drug metabolism and pharmacokinetics, 29 1, 4-11Downes, Kevin J; Hahn, Andrea; Wiles, Jason; Courter, Joshua D; Vinks, Alexander A 2014. Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics. International journal of antimicrobial agents, 43 3, 223-30Filler, Guido; Vinks, Alexander A; Huang, Shih-Han S; Jevnikar, Anthony; Muirhead, Norman 2014. Similar MPA exposure on modified release and regular tacrolimus. Therapeutic drug monitoring, 36 3, 353-7Jarvik, Gail P; Amendola, Laura M; Berg, Jonathan S; Brothers, Kyle; Clayton, Ellen W; Chung, Wendy; Evans, Barbara J; Evans, James P; Fullerton, Stephanie M; Gallego, Carlos J; Garrison, Nanibaa' A; Gray, Stacy W; Holm, Ingrid A; Kullo, Iftikhar J; Lehmann, Lisa Soleymani; McCarty, Cathy; Prows, Cynthia A; Rehm, Heidi L; Sharp, Richard R; Salama, Joseph; Sanderson, Saskia; Van Driest, Sara L; Williams, Marc S; Wolf, Susan M; Wolf, Wendy A ; Burke, Wylie 2014. Return of genomic results to research participants: the floor, the ceiling, and the choices in between. American journal of human genetics, 94 6, 818-26Jodele, Sonata; Fukuda, Tsuyoshi; Vinks, Alexander; Mizuno, Kana; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Teusink, Ashley; Pluthero, Fred G; Lu, Lily; Licht, Christoph; Davies, Stella M 2014. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20 4, 518-25Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Masuda, Satohiro; Uemoto, Shinji; Matsubara, Kazuo; Inui, Ken-Ichi; Vinks, Alexander A 2014. Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children. British journal of clinical pharmacology, 77 5, 910-2Mizuno, Tomoyuki; Fukudo, Masahide; Fukuda, Tsuyoshi; Terada, Tomohiro; Dong, Min; Kamba, Tomomi; Yamasaki, Toshinari; Ogawa, Osamu; Katsura, Toshiya; Inui, Ken-Ichi; Vinks, Alexander A; Matsubara, Kazuo 2014. The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma. Therapeutic drug monitoring, 36 3, 310-6Nehus, Edward J; Mouksassi, Samer; Vinks, Alexander A; Goldstein, Stuart 2014. Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates. Journal of clinical pharmacology, 54 12, 1421-8Rasmussen-Torvik, L J; Stallings, S C; Gordon, A S; Almoguera, B; Basford, M A; Bielinski, S J; Brautbar, A; Brilliant, M H; Carrell, D S; Connolly, J J; Crosslin, D R; Doheny, K F; Gallego, C J; Gottesman, O; Kim, D S; Leppig, K A; Li, R; Lin, S; Manzi, S; Mejia, A R; Pacheco, J A; Pan, V; Pathak, J; Perry, C L; Peterson, J F; Prows, C A; Ralston, J; Rasmussen, L V; Ritchie, M D; Sadhasivam, S; Scott, S A; Smith, M; Vega, A; Vinks, A A; Volpi, S; Wolf, W A; Bottinger, E; Chisholm, R L; Chute, C G; Haines, J L; Harley, J B; Keating, B; Holm, I A; Kullo, I J; Jarvik, G P; Larson, E B; Manolio, T; McCarty, C A; Nickerson, D A; Scherer, S E; Williams, M S; Roden, D M; Denny, J C 2014. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clinical pharmacology and therapeutics, 96 4, 482-9Roberts, Jason A; Abdul-Aziz, Mohd H; Lipman, Jeffrey; Mouton, Johan W; Vinks, Alexander A; Felton, Timothy W; Hope, William W; Farkas, Andras; Neely, Michael N; Schentag, Jerome J; Drusano, George; Frey, Otto R; Theuretzbacher, Ursula; Kuti, Joseph L 2014. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. The Lancet. Infectious diseases, 14 6, 498-509Sherwin, Catherine M T; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar; Vinks, Alexander A 2014. Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study. Current clinical pharmacology, 9 1, 64-9Smits, Thomas A; Cox, Shareen; Fukuda, Tsuyoshi; Sherbotie, Joseph R; Ward, Robert M; Goebel, Jens; Vinks, Alexander A 2014. Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients. Therapeutic drug monitoring, 36 6, 716-23Venkatasubramanian, Raja; Fukuda, Tsuyoshi; Niu, Jing; Mizuno, Tomoyuki; Chidambaran, Vidya; Vinks, Alexander A; Sadhasivam, Senthilkumar 2014. ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics, 15 10, 1297-309Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander A; Cantor, Alan; Korf, Bruce; Perentesis, John; Gutmann, David H; Schorry, Elizabeth; Packer, Roger; Fisher, Michael J 2014. Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatric blood & cancer, 61 6, 982-6Wiles, Jason R; Isemann, Barbara; Ward, Laura P; Vinks, Alexander A; Akinbi, Henry 2014. Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure. The Journal of pediatrics, 165 3, 440-6Chidambaran, Vidya; Sadhasivam, Senthilkumar; Diepstraten, Jeroen; Esslinger, Hope; Cox, Shareen; Schnell, Beverly M; Samuels, Paul; Inge, Thomas; Vinks, Alexander A; Knibbe, Catherijne A 2013. Evaluation of propofol anesthesia in morbidly obese children and adolescents. BMC anesthesiology, 13 , 8Diepstraten, J; Chidambaran, V; Sadhasivam, S; Blussé van Oud-Alblas, H J; Inge, T; van Ramshorst, B; van Dongen, E P A; Vinks, A A; Knibbe, C A J 2013. An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children. CPT: pharmacometrics & systems pharmacology, 2 9, e73Emoto, C; Fukuda, T; Cox, S; Christians, U; Vinks, A A 2013. Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. CPT: pharmacometrics & systems pharmacology, 2 7, e59Fukuda, Tsuyoshi; Chidambaran, Vidya; Mizuno, Tomoyuki; Venkatasubramanian, Raja; Ngamprasertwong, Pornswan; Olbrecht, Vanessa; Esslinger, Hope R; Vinks, Alexander A; Sadhasivam, Senthilkumar 2013. OCT1 genetic variants influence the pharmacokinetics of morphine in children. Pharmacogenomics, 14 10, 1141-51Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Adamson, Peter C 2013. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia, 54 1, 141-55Gottesman, Omri; Kuivaniemi, Helena; Tromp, Gerard; Faucett, W Andrew; Li, Rongling; Manolio, Teri A; Sanderson, Saskia C; Kannry, Joseph; Zinberg, Randi; Basford, Melissa A; Brilliant, Murray; Carey, David J; Chisholm, Rex L; Chute, Christopher G; Connolly, John J; Crosslin, David; Denny, Joshua C; Gallego, Carlos J; Haines, Jonathan L; Hakonarson, Hakon; Harley, John; Jarvik, Gail P; Kohane, Isaac; Kullo, Iftikhar J; Larson, Eric B; McCarty, Catherine; Ritchie, Marylyn D; Roden, Dan M; Smith, Maureen E; Böttinger, Erwin P; Williams, Marc S 2013. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in medicine : official journal of the American College of Medical Genetics, 15 10, 761-71Hahn, Andrea; Vinks, Alexander A 2013. Lower vancomycin serum trough concentrations might not be the answer. The Pediatric infectious disease journal, 32 12, 1403-4Pian, Phillip; Labovitz, Edward; Hoffman, Keith; Clavijo, Claudia F; Rzasa Lynn, Rachael; Galinkin, Jeffrey L; Vinks, Alexander A; Malik, Punam; Christians, Uwe 2013. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 937 , 79-83Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2013. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1. Therapeutic drug monitoring, 35 3, 332-7Vinks, A A 2013. The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women. CPT: pharmacometrics & systems pharmacology, 2 3, e33Wang, Chenguang; Sadhavisvam, Senthilkumar; Krekels, Elke H J; Dahan, Albert; Tibboel, Dick; Danhof, Meindert; Vinks, Alexander A; Knibbe, Catherijne A J 2013. Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model. Clinical drug investigation, 33 7, 523-34Abdel-Rahman, Susan M; Amidon, Gordon L; Kaul, Ajay; Lukacova, Viera; Vinks, Alexander A; Knipp, Gregory T 2012. Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group. Clinical therapeutics, 34 11, S11-24Cattaneo, Dario; Vinks, Alexander A 2012. Optimizing immunosuppressive drug dosing in pediatric renal transplantation. Part of a special series on Paediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni. Pharmacological research, 65 2, 163-7Chidambaran, Vidya; Ngamprasertwong, Pornswan; Vinks, Alexander A; Sadhasivam, Senthilkumar 2012. Pharmacogenetics and anesthetic drugs. Current clinical pharmacology, 7 2, 78-101Cohen, Mindy; Sadhasivam, Senthilkumar; Vinks, Alexander A 2012. Pharmacogenetics in perioperative medicine. Current opinion in anaesthesiology, 25 4, 419-27Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size. Clinical pharmacokinetics, 51 8, 543-551Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol clearance in morbidly obese children and adolescents: influence of age and body size. Clinical pharmacokinetics, 51 8, 543-51Fukuda, Tsuyoshi; Goebel, Jens; Cox, Shareen; Maseck, Denise; Zhang, Kejian; Sherbotie, Joseph R; Ellis, Eileen N; James, Laura P; Ward, Robert M; Vinks, Alexander A 2012. UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients. Therapeutic drug monitoring, 34 6, 671-679Hooper, David K; Fukuda, Tsuyoshi; Gardiner, Rhonda; Logan, Barbara; Roy-Chaudhury, Ashwini; Kirby, Cassie L; Vinks, Alexander A; Goebel, Jens 2012. Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation. Transplantation, 93 8, 806-12Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne 2012. Update in Fetal Anesthesia for the Ex Utero Intrapartum Treatment (EXIT) Procedure. International anesthesiology clinics, 50 4, 26-40Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Brunner, Hermine I; Vinks, Alexander A 2012. Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. British journal of clinical pharmacology, 73 5, 727-40Sherwin, Catherine M T; Saldaña, Shannon N; Bies, Robert R; Aman, Michael G; Vinks, Alexander A 2012. Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents. Therapeutic drug monitoring, 34 5, 535-44Wiles, Jason R; Vinks, Alexander A; Akinbi, Henry 2012. Federal Legislation and the Advancement of Neonatal Drug Studies. The Journal of pediatrics, , Brandhorst, Gunnar; Oellerich, Michael; Brunet, Mercè; Kowalski, Richard; Vinks, Alexander; Wallemacq, Pierre 2011. Individually tailored immunosuppression: is there a role for biomarkers? Clinical chemistry, 57 3, 376-81Fukuda, Tsuyoshi; Brunner, Hermine I; Sagcal-Gironella, Anna Carmela P; Vinks, Alexander A 2011. Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Therapeutic drug monitoring, 33 5, 658-62Fukuda, Tsuyoshi; Goebel, Jens; Thøgersen, Håvard; Maseck, Denise; Cox, Shareen; Logan, Barbara; Sherbotie, Joseph; Seikaly, Mouin; Vinks, Alexander A 2011. Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients. Journal of clinical pharmacology, 51 3, 309-20Li, Zhiping; Wang, Li; Wang, Yi; Gui, Yonghao H; Vinks, Alexander A; MacLeod, Stuart 2011. Better medicines for 300 million children in China: report on recent progress. Paediatric drugs, 13 3, 137-40Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M; Meinzen-Derr, Jareen; Shi, Jing; Balmakund, Tonya; Vinks, Alexander A 2011. Pharmacokinetics of levetiracetam in neonates with seizures. The Journal of pediatrics, 159 1, 152-154.e3Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina; Cox, Shareen; Nelson, Shannen; Dina, Blair; Sherwin, Catherine M T; Klein-Gitelman, Marisa S; Vinks, Alexander A; Brunner, Hermine I 2011. Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus. Seminars in arthritis and rheumatism, 40 4, 307-13Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G; Rieder, Michael J; Brunner, Hermine I; Vinks, Alexander A 2011. Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study. Clinical therapeutics, 33 10, 1524-36Saldaña, Shannon N; Hooper, David K; Froehlich, Tanya E; Campbell, Kathleen M; Prows, Cynthia A; Sadhasivam, Senthilkumar; Nick, Todd G; Seid, Michael; Vinks, Alexander A; Glauser, Tracy A 2011. Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies. Clinical therapeutics, 33 12, 2072-81Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer; Spigarelli, Michael G; Vinks, Alexander A 2011. Optimal study design for pioglitazone in septic pediatric patients. Journal of pharmacokinetics and pharmacodynamics, 38 4, 433-47Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I; Goebel, Jens; Vinks, Alexander A 2011. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clinical pharmacokinetics, 50 1, 1-24Tett, Susan E; Saint-Marcoux, Franck; Staatz, Christine E; Brunet, Merce; Vinks, Alexander A; Miura, Masatomo; Marquet, Pierre; Kuypers, Dirk R; van Gelder, Teun; Cattaneo, Dario 2011. Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure. Transplantation reviews (Orlando, Fla.), 25 2, 47-57Tönshoff, Burkhard; David-Neto, Elias; Ettenger, Robert; Filler, Guido; van Gelder, Teun; Goebel, Jens; Kuypers, Dirk R J; Tsai, Eileen; Vinks, Alexander A; Weber, Lutz T; Zimmerhackl, Lothar Bernd 2011. Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation. Transplantation reviews (Orlando, Fla.), 25 2, 78-89Vinks, Alexander A 2011. Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics. The Journal of pediatrics, 159 3, 361-3Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Capparelli, Edmund V; Adamson, Peter C 2010. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. The New England journal of medicine, 362 9, 790-9Kuypers, Dirk R J; Le Meur, Yannick; Cantarovich, Marcelo; Tredger, Michael J; Tett, Susan E; Cattaneo, Dario; Tönshoff, Burkhard; Holt, David W; Chapman, Jeremy; Gelder, Teun van 2010. Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation. Clinical journal of the American Society of Nephrology : CJASN, 5 2, 341-58Mehta, Parinda A; Vinks, Alexander A; Filipovich, Alexandra; Bleesing, Jack; Jodele, Sonata; Jordan, Michael B; Marsh, Rebecca; Tarin, Richard; Edwards, Stephanie; Fearing, Deborah; Lawrence, Julia; Davies, Stella M 2010. Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 16 10, 1458-62Soldin, Offie P; Soldin, Steven J; Vinks, Alexander A; Younis, Islam; Landy, Helain J 2010. Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study. Therapeutic drug monitoring, 32 6, 767-73Vargus-Adams, Jilda N; McMahon, Mary A; Michaud, Linda J; Bean, Judy; Vinks, Alexander A 2010. Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique. PM & R : the journal of injury, function, and rehabilitation, 2 1, 37-42Mouksassi, M S; Marier, J F; Cyran, J; Vinks, A A 2009. Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome. Clinical pharmacology and therapeutics, 86 6, 667-71Pestian, John; Spencer, Malik; Matykiewicz, Pawel; Zhang, Kejian; Vinks, Alexander A; Glauser, Tracy 2009. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomedical informatics insights, 2 , 19-29Prausa, S E; Fukuda, T; Maseck, D; Curtsinger, K L; Liu, C; Zhang, K; Nick, T G; Sherbotie, J R; Ellis, E N; Goebel, J; Vinks, A A 2009. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clinical pharmacology and therapeutics, 85 5, 495-500Prows, Cynthia A; Nick, Todd G; Saldaña, Shannon N; Pathak, Sanjeev; Liu, Chunyan; Zhang, Kejian; Daniels, Zachary S; Vinks, Alexander A; Glauser, Tracy A 2009. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. Journal of child and adolescent psychopharmacology, 19 4, 385-94Thompson, Patrick A; Allen, Carl E; Horton, Terzah; Jones, Jeremy Y; Vinks, Alexander A; McClain, Kenneth L 2009. Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 52 5, 621-5Aman, Michael G; Vinks, Alexander A; Remmerie, Bart; Mannaert, Erik; Ramadan, Yaser; Masty, Jessica; Lindsay, Ronald L; Malone, Krista 2007. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clinical therapeutics, 29 7, 1476-86Cabovska, B; Cox, S L; Vinks, A A 2007. Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 852 1-2, 497-504Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2007. Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo. Antimicrobial agents and chemotherapy, 51 9, 3449-51Mouton, Johan W; Vinks, Alexander A 2007. Continuous infusion of beta-lactams. Current opinion in critical care, 13 5, 598-606Syed, Azeem; Vinks, Alexander A; Zakowski, Jack 2007. Trend in therapeutic monitoring of immunosuppressive drugs. MLO: medical laboratory observer, 39 7, 31-2Vinks, Alexander A; van Rossem, Ronald N; Mathôt, Ron A A; Heijerman, Harry G M; Mouton, Johan W 2007. Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation. Antimicrobial agents and chemotherapy, 51 9, 3049-55Weimert, Nicole A; Derotte, Maurits; Alloway, Rita R; Woodle, E Steve; Vinks, Alexander A 2007. Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications. Therapeutic drug monitoring, 29 2, 141-9Jiang, Zhengwen; Dragin, Nadine; Jorge-Nebert, Lucia F; Martin, Martha V; Guengerich, F Peter; Aklillu, Eleni; Ingelman-Sundberg, Magnus; Hammons, George J; Lyn-Cook, Beverly D; Kadlubar, Fred F; Saldana, Shannon N; Sorter, Michael; Vinks, Alexander A; Nassr, Nassr; von Richter, Oliver; Jin, Li; Nebert, Daniel W 2006. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenetics and genomics, 16 5, 359-67Mehta, Parinda; Vinks, Alexander; Filipovich, Alexandra; Vaughn, Gretchen; Fearing, Deborah; Sper, Christine; Davies, Stella 2006. High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 2, 235-40Carlsson, Kristin Cecilie; Hoem, Nils Ove; Glauser, Tracy; Vinks, Alexander A 2005. Development of a population pharmacokinetic model for carbamazepine based on sparse therapeutic monitoring data from pediatric patients with epilepsy. Clinical therapeutics, 27 5, 618-26de Wildt, Saskia N; de Hoog, Matthijs; Vinks, Alexander A; Joosten, Koen F M; van Dijk, Monique; van den Anker, John N 2005. Pharmacodynamics of midazolam in pediatric intensive care patients. Therapeutic drug monitoring, 27 1, 98-102Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2005. A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit. Clinical therapeutics, 27 6, 762-72Mouton, Johan W; Vinks, Alexander A 2005. Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations. Clinical pharmacokinetics, 44 7, 767-8Mouton, Johan W; Vinks, Alexander A 2005. Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration. Clinical pharmacokinetics, 44 2, 201-10Touw, D J; Neef, C; Thomson, A H; Vinks, A A 2005. Cost-effectiveness of therapeutic drug monitoring: a systematic review. Therapeutic drug monitoring, 27 1, 10-7Bos, A M E; Boom, K; Vinks, A A; Boezen, H M; Wanders, J; Dombernovsky, P; Aamdal, S; de Vries, E G E; Uges, D R A 2004. Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755. Cancer chemotherapy and pharmacology, 54 1, 64-70de Wildt, S N; de Hoog, M; Vinks, A A; van der Giesen, E; van den Anker, J N 2003. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Critical care medicine, 31 7, 1952-8Sallee, Floyd R; Gilbert, Donald L; Vinks, Alexander A; Miceli, Jeffrey J; Robarge, Lisa; Wilner, Keith 2003. Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission. Journal of the American Academy of Child and Adolescent Psychiatry, 42 8, 902-7Vinks, Alexander A; Den Hollander, Jan G; Overbeek, Shelley E; Jelliffe, Roger W; Mouton, Johan W 2003. Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis. Antimicrobial agents and chemotherapy, 47 2, 541-7de Hoog, Matthijs; Schoemaker, Rik C; van den Anker, John N; Vinks, Alexander A 2002. NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates. Therapeutic drug monitoring, 24 3, 359-65Le Brun, P P H; de Boer, A H; Mannes, G P M; de Fraîture, D M I; Brimicombe, R W; Touw, D J; Vinks, A A; Frijlink, H W; Heijerman, H G M 2002. Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 54 1, 25-32Vinks, Alexander A 2002. The application of population pharmacokinetic modeling to individualized antibiotic therapy. International journal of antimicrobial agents, 19 4, 313-22Beringer, P M; Vinks, A A; Jelliffe, R W; Shapiro, B J 2000. Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration. Antimicrobial agents and chemotherapy, 44 4, 809-13Le Brun, P P; de Graaf, A I; Vinks, A A 2000. High-performance liquid chromatographic method for the determination of colistin in serum. Therapeutic drug monitoring, 22 5, 589-93Mouton, J W; Touzw, D J; Horrevorts, A M; Vinks, A A 2000. Comparative pharmacokinetics of the carbapenems: clinical implications. Clinical pharmacokinetics, 39 3, 185-201Natsch, S; Vinks, M H; Voogt, A K; Mees, E B; Meyboom, R H 2000. Anaphylactic reactions to proton-pump inhibitors. The Annals of pharmacotherapy, 34 4, 474-6Ververs, T F; van Dijk, A; Vinks, S A; Blankestijn, P J; Savelkoul, J F; Meulenbelt, J; Boereboom, F T 2000. Pharmacokinetics and dosing regimen of meropenem in critically ill patients receiving continuous venovenous hemofiltration. Critical care medicine, 28 10, 3412-6Le Brun, P P; Vinks, A A; Touw, D J; Hekelaar, N; Mannes, G P; Brimicombe, R W; Frijlink, E H; Heijerman, H G 1999. Can tobramycin inhalation be improved with a jet nebulizer? Therapeutic drug monitoring, 21 6, 618-24Morris, R G; Sallustio, B C; Vinks, A A; LeGatt, D F; Verjee, Z H; El Desoky, E 1999. Some international approaches to aminoglycoside monitoring in the extended dosing interval era. Therapeutic drug monitoring, 21 4, 379-88van Lent-Evers, N A; Mathôt, R A; Geus, W P; van Hout, B A; Vinks, A A 1999. Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis. Therapeutic drug monitoring, 21 1, 63-73Beringer, P M; Vinks, A A; Jelliffe, R W 1998. Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis. The Journal of antimicrobial chemotherapy, 41 1, 142-4Touw, D J; Vinks, A A; Mouton, J W; Horrevorts, A M 1998. Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions. Clinical pharmacokinetics, 35 6, 437-59Visser, L; Stricker, B; Hoogendoorn, M; Vinks, A 1998. Do not give paraffin to packers. Lancet (London, England), 352 9137, 1352Meyboom, R H; van Puijenbroek, E P; Vinks, M H; Lastdrager, C J 1997. Disturbance of withdrawal bleeding during concomitant use of itraconazole and oral contraceptives. The New Zealand medical journal, 110 1049, 300Mouton, J W; Vinks, A A; Punt, N C 1997. Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrobial agents and chemotherapy, 41 4, 733-8Touw, D J; Vinks, A A; Neef, C 1997. Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm. Pharmacy world & science : PWS, 19 3, 142-51Vinks, A A; Brimicombe, R W; Heijerman, H G; Bakker, W 1997. Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics. The Journal of antimicrobial chemotherapy, 40 1, 125-33Mouton, J W; Vinks, A A 1996. Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations. The Journal of antimicrobial chemotherapy, 38 1, 5-15Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1996. Prospective evaluation of a dose prediction algorithm for intravenous tobramycin in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 2, 118-23Town, D J; Vinks, A A; Jacobs, F; Heijerman, H G; Bakker, W 1996. Creatinine clearance as predictor of tobramycin elimination in adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 5, 562-9Vinks, A A; Mouton, J W; Touw, D J; Heijerman, H G; Danhof, M; Bakker, W 1996. Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategy. Antimicrobial agents and chemotherapy, 40 5, 1091-7Vinks, A A; Touw, D J; van Rossen, R C; Heijerman, H G; Bakker, W 1996. Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT). Pharmacy world & science : PWS, 18 2, 74-7Touw, D J; Vinks, A A; Heijerman, H G; Hermans, J; Bakker, W 1994. Suggestions for the optimization of the initial tobramycin dose in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 16 2, 125-31Vinks, A A; Touw, D J; Heijerman, H G; Danhof, M; de Leede, G P; Bakker, W 1994. Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home. Therapeutic drug monitoring, 16 4, 341-8Bakker, W; Vinks, A A; Mouton, J W; de Jonge, P; Verzijl, J G; Heijerman, H G 1993. [Continuous intravenous home treatment of airway infections using ceftazidime administration via portable pump in patients with cystic fibrosis; a multicenter study]. Nederlands tijdschrift voor geneeskunde, 137 48, 2486-91Geus, W P; Vinks, A A; Smith, S J; Westra, P; Lamers, C B 1993. Comparison of two intravenous ranitidine regimens in a homogeneous population of intensive care unit patients. Alimentary pharmacology & therapeutics, 7 4, 451-7Mouton, J W; Vinks, A A 1993. [Antimicrobial treatment using beta-lactam antibiotics: continuous infusion appears to be sensible]. Nederlands tijdschrift voor geneeskunde, 137 48, 2476-80Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1993. Validation of tobramycin monitoring in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 15 1, 52-9Vinks, S A; Heijerman, H G; de Jonge, P; Bakker, W 1993. Photosensitivity due to ambulatory intravenous ceftazidime in cystic fibrosis patient. Lancet (London, England), 341 8854, 1221-2Geus, W P; Vinks, A A; Lamers, C B 1992. Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration. Scandinavian journal of gastroenterology. Supplement, 194 , 55-8Melissant, C F; Vinks, A A; Sleeboom, H P 1992. [Coma due to an overdose of valnoctamide]. Nederlands tijdschrift voor geneeskunde, 136 16, 793-4Hoogslag, P A; van Dijk, B; Vinks, A A 1989. [Respiratory depression following controlled-release morphine sulfate tablets]. Nederlands tijdschrift voor geneeskunde, 133 10, 516-7Keukens, F; van Voorst Vader, P C; Panders, A K; Vinks, S; Oosterhuis, J W; Kleijer, W J 1989. Xeroderma pigmentosum: squamous cell carcinoma of the tongue. Acta dermato-venereologica, 69 6, 530-1Inaba, T; Vinks, A; Otton, S V 1986. A simple borohydride/GC method for measuring sparteine metabolites in man. British journal of clinical pharmacology, 21 5, 473-80Van der Graaff, M; Vermeulen, N P; Vinks, M H; Breimer, D D 1986. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European journal of drug metabolism and pharmacokinetics, 11 2, 107-11Inaba, T; Vinks, A; Otton, S V; Kalow, W 1983. Comparative pharmacogenetics of sparteine and debrisoquine. Clinical pharmacology and therapeutics, 33 3, 394-9Slee, G L; Vinks, J A 1983. [Ileus following the use of loperamide (Imodium)]. Nederlands tijdschrift voor geneeskunde, 127 40, 1821-2Vinks, A; Inaba, T; Otton, S V; Kalow, W 1982. Sparteine metabolism in Canadian Caucasians. Clinical pharmacology and therapeutics, 31 1, 23-9Rogers, Christin C; Alloway, Rita R; Alexander, J Wesley; Cardi, Michael; Trofe, Jennifer; Vinks, Alexander A . Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study. Clinical transplantation, 22 3, 281-91Sadhasivam, Senthilkumar; Krekels, Elke H J; Chidambaran, Vidya; Esslinger, Hope R; Ngamprasertwong, Pornswan; Zhang, Kejian; Fukuda, Tsuyoshi; Vinks, Alexander A . Morphine clearance in children: does race or genetics matter? Journal of opioid management, 8 4, 217-26Williams, Michael T; Brown, Carrie A; Skelton, Matthew R; Vinks, Alexander A; Vorhees, Charles V . Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats. Neurotoxicology and teratology, 26 6, 849-56
Cervantes, Francisco C; Mizuno, Tomoyuki; Dong, Min; Tang, Peter; Arbough, Trent; Vinks, Alexander A; Kaplan, Jennifer M; Tang Girdwood, Sonya C 2023. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic drug monitoring, 45 6, 832-836Choi, Yewon; Vinks, Alexander A; van der Graaf, Piet H 2023. Novel Therapeutic Modalities: The Future is Now. Clinical pharmacology and therapeutics, 114 3, 493-496Dong, Min; Ware, Russell E; Dallmann, André; Vinks, Alexander A 2023. Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps. Pharmacotherapy, 43 5, 419-429Jodele, Sonata; Mizuno, Kana; Sabulski, Anthony; Vinks, Alexander A 2023. Adopting Model-Informed Precision-Dosing for Eculizumab in Transplant Associated-Thrombotic Microangiopathy to Gene Therapies. Clinical pharmacology and therapeutics, 114 3, 511-514McIntire, Carter; Luna Torres, Julie; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Tang Girdwood, Sonya 2023. Piperacillin Pharmacokinetics and Pharmacodynamics in Paediatric Patients Who Received High Frequency Intra-Operative Piperacillin/Tazobactam Dosing. International journal of antimicrobial agents, 63 3, 107079Mizuno, Kana; Capparelli, Edmund V; Fukuda, Tsuyoshi; Dong, Min; Adamson, Peter C; Blumer, Jeffery L; Cnaan, Avital; Clark, Peggy O; Reed, Michael D; Shinnar, Shlomo; Vinks, Alexander A; Glauser, Tracy A 2023. Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. Clinical pharmacology and therapeutics, 114 2, 459-469Pavia, Kathryn; Hambrick, H Rhodes; Paice, Kelli; Tang, Peter; Punt, Nieko; Kaplan, Jennifer; Goldstein, Stuart L; Vinks, Alexander A; Mizuno, Tomoyuki; Tang Girdwood, Sonya 2023. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. The Journal of antimicrobial chemotherapy, 78 9, 2140-2147Poweleit, Ethan A; Vinks, Alexander A; Mizuno, Tomoyuki 2023. Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic drug monitoring, , Power-Hays, Alexandra; Dong, Min; Punt, Nieko; Mizuno, Tomoyuki; Smart, Luke R; Vinks, Alexander A; Ware, Russell E 2023. Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia. Clinical pharmacology and therapeutics, , Ramsey, Laura B; Prows, Cynthia A; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Quinn, Charles T; Teusink-Cross, Ashley; Girdwood, Sonya Tang; Dawson, D Brian; Vinks, Alexander A; Glauser, Tracy A 2023. Implementation of CYP2D6-guided opioid therapy at Cincinnati Children's Hospital Medical Center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, , Smart, Luke R; Charles, Mwesige; McElhinney, Kathryn E; Dong, Min; Power-Hays, Alexandra; Howard, Thad; Vinks, Alexander A; Ambrose, Emmanuela E; Ware, Russell E 2023. Hydroxyurea pharmacokinetics and precision dosing in low-resource settings. Frontiers in molecular biosciences, 10 , 1130206Tang Girdwood, Sonya; Hasson, Denise; Caldwell, J Timothy; Slagle, Cara; Dong, Shun; Fei, Lin; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer; Goldstein, Stuart L 2023. Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury. The Journal of antimicrobial chemotherapy, 78 2, 478-487Tang Girdwood, Sonya; Tang, Peter; Fenchel, Matthew; Dong, Min; Stoneman, Erin; Jones, Rhonda; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Diseroad, Emily; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2023. Pharmacokinetic Parameters over Time during Sepsis and the Association of Target Attainment and Outcomes in Critically Ill Children and Young Adults Receiving Ceftriaxone. Pharmacotherapy, , Taylor, Zachary L; Poweleit, Ethan A; Paice, Kelli; Somers, Katherine M; Pavia, Kathryn; Vinks, Alexander A; Punt, Nieko; Mizuno, Tomoyuki; Girdwood, Sonya Tang 2023. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: pharmacometrics & systems pharmacology, 12 12, 1827-1845Chandra, Sharat; Mizuno, Kana; Zhao, Junfang; Davies, Stella M; Marsh, Rebecca A; Fukuda, Tsuyoshi; Setchell, Kenneth D R; Vinks, Alexander A; Mehta, Parinda A 2022. Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders. British journal of clinical pharmacology, 88 1, 115-127Colman, Ruben J; Mizuno, Tomoyuki; Fukushima, Keizo; Haslam, David B; Hyams, Jeffrey S; Boyle, Brendan; Noe, Joshua D; D'Haens, Geert R; Van Limbergen, Johan; Chun, Kelly; Yang, Jane; Denson, Lee A; Ollberding, Nicholas J; Vinks, Alexander A; Minar, Phillip 2022. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary pharmacology & therapeutics, , Colman, Ruben J; Samuels, Abigail; Mizuno, Tomoyuki; Punt, Nieko; Vinks, Alexander A; Minar, Phillip 2022. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases, , Colman, Ruben J; Xiong, Ye; Mizuno, Tomoyuki; Hyams, Jeffrey S; Noe, Joshua D; Boyle, Brendan; D'Haens, Geert R; van Limbergen, Johan; Chun, Kelly; Yang, Jane; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2022. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary pharmacology & therapeutics, 55 5, 593-603Dong, Min; Emoto, Chie; Fukuda, Tsuyoshi; Arnold, Danielle E; Mehta, Parinda A; Marsh, Rebecca A; Vinks, Alexander A 2022. Model-informed precision dosing for alemtuzumab in paediatric and young adult patients undergoing allogeneic haematopoietic cell transplantation. British journal of clinical pharmacology, 88 1, 248-259Miyagawa, Bradley; Lazear, Danielle; Hooper, David K; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Model-informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient with Posterior Reversible Encephalopathy Syndrome. Therapeutic drug monitoring, , Mizuno, Kana; Dandoy, Christopher E; Teusink-Cross, Ashley; Davies, Stella M; Vinks, Alexander A; Jodele, Sonata 2022. Eculizumab precision-dosing algorithm for thrombotic microangiopathy in children and young adults undergoing HSCT. Blood advances, 6 5, 1454-1463Mizuno, Tomoyuki; Dong, Min; Taylor, Zachary L; Ramsey, Laura B; Vinks, Alexander A 2022. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British journal of clinical pharmacology, 88 4, 1418-1426Tang Girdwood, Sonya; Dong, Min; Tang, Peter; Stoneman, Erin; Jones, Rhonda; Yunger, Toni; Ostermeier, Austin; Curry, Calise; Forton, Melissa; Hail, Traci; Mullaney, Randi; Lahni, Patrick; Punt, Nieko; Kaplan, Jennifer; Vinks, Alexander A 2022. Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Attainment. Antimicrobial agents and chemotherapy, 66 1, e0142721Tang Girdwood, Sonya; Pavia, Kathryn; Paice, Kelli; Hambrick, H Rhodes; Kaplan, Jennifer; Vinks, Alexander A 2022. β-lactam precision dosing in critically ill children: Current state and knowledge gaps. Frontiers in pharmacology, 13 , 1044683van Hoogdalem, Matthijs W; Johnson, Trevor N; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott L; Ward, Laura P; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical pharmacology and therapeutics, 111 2, 496-508van Hoogdalem, Matthijs W; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2022. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology & therapeutics, 234 , 108045Whaley, Kaitlin G; Xiong, Ye; Karns, Rebekah; Hyams, Jeffrey S; Kugathasan, Subra; Boyle, Brendan M; Walters, Thomas D; Kelsen, Judith; LeLeiko, Neal; Shapiro, Jason; Waddell, Amanda; Fox, Sejal; Bezold, Ramona; Bruns, Stephanie; Widing, Robin; Haberman, Yael; Collins, Margaret H; Mizuno, Tomoyuki; Minar, Phillip; D'Haens, Geert R; Denson, Lee A; Vinks, Alexander A; Rosen, Michael J 2022. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, , Yi, Jae-Sung; Perla, Sravan; Huang, Yan; Mizuno, Kana; Giordano, Frank J; Vinks, Alexander A; Bennett, Anton M 2022. Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. Cardiovascular drugs and therapy, 36 4, 589-604Arnold, Danielle E; Emoto, Chie; Fukuda, Tsuyoshi; Dong, Min; Vinks, Alexander A; Lane, Adam; McIntosh, Kelly; Neumeier, Lisa; Lankester, Arjan C; Achini, Federica; Teusink-Cross, Ashley; Chandra, Sharat; Jordan, Michael B; Nelson, Adam S; Myers, Kasiani C; Davies, Stella M; Mehta, Parinda A; Marsh, Rebecca A 2021. A prospective pilot study of a novel alemtuzumab target concentration intervention strategy. Bone marrow transplantation, 56 12, 3029-3031Barrett, Jeffrey S; Barrett, Ryan F; Vinks, Alexander A 2021. Status Toward the Implementation of Precision Dosing in Children. Journal of clinical pharmacology, 61 Suppl 1 , S36-S51Bergan, Stein; Brunet, Mercè; Hesselink, Dennis A; Johnson-Davis, Kamisha L; Kunicki, Paweł K; Lemaitre, Florian; Marquet, Pierre; Molinaro, Mariadelfina; Noceti, Ofelia; Pattanaik, Smita; Pawinski, Tomasz; Seger, Christoph; Shipkova, Maria; Swen, Jesse J; van Gelder, Teun; Venkataramanan, Raman; Wieland, Eberhard; Woillard, Jean-Baptiste; Zwart, Tom C; Barten, Markus J; Budde, Klemens; Dieterlen, Maja-Theresa; Elens, Laure; Haufroid, Vincent; Masuda, Satohiro; Millan, Olga; Mizuno, Tomoyuki; Moes, Dirk J A R; Oellerich, Michael; Picard, Nicolas; Salzmann, Linda; Tönshoff, Burkhard; van Schaik, Ron H N; Vethe, Nils Tore; Vinks, Alexander A; Wallemacq, Pierre; Åsberg, Anders; Langman, Loralie J 2021. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic drug monitoring, 43 2, 150-200Boucher, Alexander A; Dong, Min; Vinks, Alexander A; Marahatta, Anu; Howard, Thad A; Ware, Russell E; Nathan, Jaimie D; Abu-El-Haija, Maisam; Luchtman-Jones, Lori 2021. Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation. Journal of clinical pharmacology, 61 4, 547-554Dong, Min; Rodriguez, Anna V; Blankenship, Chelsea A; McPhail, Gary; Vinks, Alexander A; Hunter, Lisa L 2021. Pharmacokinetic modelling to predict risk of ototoxicity with intravenous tobramycin treatment in cystic fibrosis. The Journal of antimicrobial chemotherapy, 76 11, 2923-2931Girdwood, Sonya Tang; Kaplan, Jennifer; Vinks, Alexander A 2021. Methodologic Progress Note: Opportunistic Sampling for Pharmacology Studies in Hospitalized Children. Journal of hospital medicine, 16 1, 35-37Karkoska, Kristine; Quinn, Charles T; Niss, Omar; Pfeiffer, Amanda; Dong, Min; Vinks, Alexander A; McGann, Patrick T 2021. Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia. American journal of hematology, 96 5, 538-544McPhail, Brooks T; Emoto, Chie; Butler, Dawn; Fukuda, Tsuyoshi; Akinbi, Henry; Vinks, Alexander A 2021. Opioid Treatment for Neonatal Opioid Withdrawal Syndrome: Current Challenges and Future Approaches. Journal of clinical pharmacology, 61 7, 857-870Mizuno, Tomoyuki; McPhail, Brooks T; Kamatkar, Suyog; Wexelblatt, Scott; Ward, Laura; Christians, Uwe; Akinbi, Henry T; Vinks, Alexander A 2021. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clinical pharmacokinetics, 60 2, 249-259Neely, Michael N; Vinks, Alexander A 2021. Roger W. Jelliffe, MD, FCP, FAAPS: A World Leader in Population Pharmacokinetic and Pharmacodynamic Modeling and Model-Based Target Controlled Individualized Dosing. Clinical pharmacology and therapeutics, 109 1, 22-24Peck, Richard W; Shahin, Mohamed H; Vinks, Alexander A 2021. Precision Dosing: The Clinical Pharmacology of Goldilocks. Clinical pharmacology and therapeutics, 109 1, 11-14Quinn, Charles T; Niss, Omar; Dong, Min; Pfeiffer, Amanda; Korpik, Jennifer; Reynaud, Mary; Bonar, Holly; Kalfa, Theodosia A; Smart, Luke R; Malik, Punam; Ware, Russell E; Vinks, Alexander A; McGann, Patrick T 2021. Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia. British journal of haematology, 194 3, 617-625Sebold, Alison J; Day, Alyssa M; Ewen, Joshua; Adamek, Jack; Byars, Anna; Cohen, Bernard; Kossoff, Eric H; Mizuno, Tomoyuki; Ryan, Matthew; Sievers, Jacqueline; Smegal, Lindsay; Suskauer, Stacy J; Thomas, Cameron; Vinks, Alexander; Zabel, T Andrew; Hammill, Adrienne M; Comi, Anne M 2021. Sirolimus Treatment in Sturge-Weber Syndrome. Pediatric neurology, 115 , 29-40Soul, Janet S; Bergin, Ann M; Stopp, Christian; Hayes, Breda; Singh, Avantika; Fortuno, Carmen R; O'Reilly, Deirdre; Krishnamoorthy, Kalpathy; Jensen, Frances E; Rofeberg, Valerie; Dong, Min; Vinks, Alexander A; Wypij, David; Staley, Kevin J 2021. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Annals of neurology, 89 2, 327-340Tang Girdwood, Sonya C; Tang, Peter H; Murphy, Mark E; Chamberlain, Andrea R; Benken, Laura A; Jones, Rhonda L; Stoneman, Erin M; Kaplan, Jennifer M; Vinks, Alexander A 2021. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology, 61 4, 565-573Taylor, Zachary L; Thompson, Lauren E; Bear, Heather; Mizuno, Tomoyuki; Vinks, Alexander A; Ramsey, Laura B 2021. Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clinical and translational science, 14 6, 2267-2277van Gelder, Teun; Vinks, Alexander A 2021. Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing. Clinical pharmacology and therapeutics, 110 2, 273-276van Hoogdalem, Matthijs W; McPhail, Brooks T; Hahn, David; Wexelblatt, Scott L; Akinbi, Henry T; Vinks, Alexander A; Mizuno, Tomoyuki 2021. Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics. Expert opinion on drug metabolism & toxicology, 17 1, 87-103Vinks, Alexander A; Barrett, Jeffrey S 2021. Model-Informed Pediatric Drug Development: Application of Pharmacometrics to Define the Right Dose for Children. Journal of clinical pharmacology, 61 Suppl 1 , S52-S59Weiss, Brian D; Wolters, Pamela L; Plotkin, Scott R; Widemann, Brigitte C; Tonsgard, James H; Blakeley, Jaishri; Allen, Jeffrey C; Schorry, Elizabeth; Korf, Bruce; Robison, Nathan J; Goldman, Stewart; Vinks, Alexander A; Emoto, Chie; Fukuda, Tsuyoshi; Robinson, Coretta T; Cutter, Gary; Edwards, Lloyd; Dombi, Eva; Ratner, Nancy; Packer, Roger; Fisher, Michael J 2021. NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39 7, 797-806Wong, Steven H; Marquet, Pierre; Cattaneo, Dario; Svinarov, Dobrin; Bergan, Stein; Walson, Philip; Vinks, Alexander A; Shipkova, Maria 2021. Therapeutic Drug Monitoring in the Era of Precision Medicine: Achievements, Gaps, and Perspectives-An Interview in Honor of Professor Charles Pippenger. Therapeutic drug monitoring, 43 6, 719-727Wright, Karen D; Yao, Xiaopan; London, Wendy B; Kao, Pei-Chi; Gore, Lia; Hunger, Stephen; Geyer, Russ; Cohen, Kenneth J; Allen, Jeffrey C; Katzenstein, Howard M; Smith, Amy; Boklan, Jessica; Nazemi, Kellie; Trippett, Tanya; Karajannis, Matthias; Herzog, Cynthia; Destefano, Joseph; Direnzo, Jennifer; Pietrantonio, Jay; Greenspan, Lianne; Cassidy, Danielle; Schissel, Debra; Perentesis, John; Basu, Mitali; Mizuno, Tomoyuki; Vinks, Alexander A; Prabhu, Sanjay P; Chi, Susan N; Kieran, Mark W 2021. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma. Pediatric blood & cancer, 68 2, e28787Xiong, Ye; Mizuno, Tomoyuki; Colman, Ruben; Hyams, Jeffrey; Noe, Joshua D; Boyle, Brendan; Tsai, Yi-Ting; Dong, Min; Jackson, Kimberly; Punt, Nieko; Rosen, Michael J; Denson, Lee A; Vinks, Alexander A; Minar, Phillip 2021. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical pharmacology and therapeutics, 109 6, 1639-1647Zhao, Junfang; Sharat, Chandra; Mehta, Parinda A; Mizuno, Kana; Vinks, Alexander A; Setchell, Kenneth D R 2021. Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan. The journal of applied laboratory medicine, 6 3, 625-636Balyan, Rajiv; Dong, Min; Pilipenko, Valentina; Geisler, Kristie; Vinks, Alexander A; Chidambaran, Vidya 2020. Hydromorphone population pharmacokinetics in pediatric surgical patients. Paediatric anaesthesia, 30 10, 1091-1101Bauman, Laura E; Xiong, Ye; Mizuno, Tomoyuki; Minar, Philip; Fukuda, Tsuyoshi; Dong, Min; Rosen, Michael J; Vinks, Alexander A 2020. Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease. Inflammatory bowel diseases, 26 3, 429-439Cazelles, Remi; Shukla, Rajendra P; Ware, Russell E; Vinks, Alexander A; Ben-Yoav, Hadar 2020. Electrochemical Determination of Hydroxyurea in a Complex Biological Matrix Using MoS2-Modified Electrodes and Chemometrics. Biomedicines, 9 1, Chen, Yewei; Sun, Li; Xu, Hong; Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A; Brunner, Hermine I; Li, Yifan; Li, Zhiping 2020. PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing. Frontiers in pharmacology, 11 , 605060Emoto, Chie; Hahn, David; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2020. Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates. Clinical pharmacology and therapeutics, 107 2, 319-320Euteneuer, Joshua C; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Zhao, Junfang; Setchell, Kenneth D R; Muglia, Louis J; Vinks, Alexander A 2020. Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants. Therapeutic drug monitoring, 42 5, 778-786Hahn, David; Fukuda, Tsuyoshi; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Sadhasivam, Senthilkumar; Emoto, Chie 2020. Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients. Journal of clinical pharmacology, 60 8, 992-998McPhail, Brooks T; Emoto, Chie; Fukuda, Tsuyoshi; Butler, Dawn; Wiles, Jason R; Akinbi, Henry; Vinks, Alexander A 2020. Utilizing Pediatric Physiologically Based Pharmacokinetic Models to Examine Factors That Contribute to Methadone Pharmacokinetic Variability in Neonatal Abstinence Syndrome Patients. Journal of clinical pharmacology, 60 4, 453-465Meier, Emily R; Creary, Susan E; Heeney, Matthew M; Dong, Min; Appiah-Kubi, Abena O; Nelson, Stephen C; Niss, Omar; Piccone, Connie; Quarmyne, Maa-Ohui; Quinn, Charles T; Saving, Kay L; Scott, John P; Talati, Ravi; Latham, Teresa S; Pfeiffer, Amanda; Shook, Lisa M; Vinks, Alexander A; Lane, Adam; McGann, Patrick T 2020. Hydroxyurea Optimization through Precision Study (HOPS): study protocol for a randomized, multicenter trial in children with sickle cell anemia. Trials, 21 1, 983Somberg, John C; Vinks, Alexander A; Dong, Min; Molnar, Janos 2020. Model-Informed Development of Sotalol Loading and Dose Escalation Employing an Intravenous Infusion. Cardiology research, 11 5, 294-304Tang Girdwood, Sonya; Arbough, Trent; Dong, Min; Mizuno, Tomoyuki; Tang, Peter; Vinks, Alexander A; Kaplan, Jennifer 2020. Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets. Pharmacotherapy, 40 10, 1061-1068Taylor, Zachary L; Mizuno, Tomoyuki; Punt, Nieko C; Baskaran, Balaji; Navarro Sainz, Adriana; Shuman, William; Felicelli, Nicholas; Vinks, Alexander A; Heldrup, Jesper; Ramsey, Laura B 2020. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical pharmacology and therapeutics, 108 3, 635-643Ullrich, Nicole J; Prabhu, Sanjay P; Reddy, Alyssa T; Fisher, Michael J; Packer, Roger; Goldman, Stewart; Robison, Nathan J; Gutmann, David H; Viskochil, David H; Allen, Jeffrey C; Korf, Bruce; Cantor, Alan; Cutter, Gary; Thomas, Coretta; Perentesis, John P; Mizuno, Tomoyuki; Vinks, Alexander A; Manley, Peter E; Chi, Susan N; Kieran, Mark W 2020. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro-oncology, 22 10, 1527-1535van Hoogdalem, Matthijs W; Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Mehta, Parinda A; Vinks, Alexander A 2020. Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients. British journal of clinical pharmacology, 86 5, 933-943Vinks, Alexander A; Peck, Richard W; Neely, Michael; Mould, Diane R 2020. Development and Implementation of Electronic Health Record-Integrated Model-Informed Clinical Decision Support Tools for the Precision Dosing of Drugs. Clinical pharmacology and therapeutics, 107 1, 129-135Vinks, Alexander A; Punt, Nieko C; Menke, Frank; Kirkendall, Eric; Butler, Dawn; Duggan, Thomas J; Cortezzo, DonnaMaria E; Kiger, Sam; Dietrich, Tom; Spencer, Paul; Keefer, Rob; Setchell, Kenneth D R; Zhao, Junfang; Euteneuer, Joshua C; Mizuno, Tomoyuki; Dufendach, Kevin R 2020. Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical pharmacology and therapeutics, 107 1, 186-194Ware, Russell E; Marahatta, Anu; Ware, Julie L; McElhinney, Kathryn; Dong, Min; Vinks, Alexander A 2020. Hydroxyurea Exposure in Lactation: a Pharmacokinetics Study (HELPS). The Journal of pediatrics, 222 , 236-239Boucher, Alexander A; Mizuno, Tomoyuki; Vinks, Alexander A; Goldstein, Stuart L; Tiao, Greg M; Geller, James I 2019. Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma. Pediatric blood & cancer, 66 1, e27425Brunet, Mercè; van Gelder, Teun; Åsberg, Anders; Haufroid, Vincent; Hesselink, Dennis A; Langman, Loralie; Lemaitre, Florian; Marquet, Pierre; Seger, Christoph; Shipkova, Maria; Vinks, Alexander; Wallemacq, Pierre; Wieland, Eberhard; Woillard, Jean Baptiste; Barten, Markus J; Budde, Klemens; Colom, Helena; Dieterlen, Maja-Theresa; Elens, Laure; Johnson-Davis, Kamisha L; Kunicki, Paweł K; MacPhee, Iain; Masuda, Satohiro; Mathew, Binu S; Millán, Olga; Mizuno, Tomoyuki; Moes, Dirk-Jan A R; Monchaud, Caroline; Noceti, Ofelia; Pawinski, Tomasz; Picard, Nicolas; van Schaik, Ron; Sommerer, Claudia; Vethe, Nils Tore; de Winter, Brenda; Christians, Uwe; Bergan, Stein 2019. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Therapeutic drug monitoring, 41 3, 261-307Emoto, Chie; Johnson, Trevor N; Hahn, David; Christians, Uwe; Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition. CPT: pharmacometrics & systems pharmacology, 8 5, 273-284Euteneuer, Joshua C; Kamatkar, Suyog; Fukuda, Tsuyoshi; Vinks, Alexander A; Akinbi, Henry T 2019. Suggestions for Model-Informed Precision Dosing to Optimize Neonatal Drug Therapy. Journal of clinical pharmacology, 59 2, 168-176Hahn, David; Emoto, Chie; Euteneuer, Joshua C; Mizuno, Tomoyuki; Vinks, Alexander A; Fukuda, Tsuyoshi 2019. Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study. Clinical pharmacology and therapeutics, 105 3, 761-768Leino, Abbie D; Emoto, Chie; Fukuda, Tsuyoshi; Privitera, Michael; Vinks, Alexander A; Alloway, Rita R 2019. Evidence of a clinically significant drug-drug interaction between cannabidiol and tacrolimus. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 10, 2944-2948Leino, Abbie D; King, Eileen C; Jiang, Wenlei; Vinks, Alexander A; Klawitter, Jost; Christians, Uwe; Woodle, E Steve; Alloway, Rita R; Rohan, Jennifer M 2019. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 19 5, 1410-1420Lichvar, Alicia; Tremblay, Simon; Naik, Devanshi; Lipscomb, Jessi; King, Eileen; Vinks, Alexander A; Christians, Uwe; Alloway, Rita R 2019. Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients. Pharmacotherapy, 39 5, 564-575McGann, Patrick T; Niss, Omar; Dong, Min; Marahatta, Anu; Howard, Thad A; Mizuno, Tomoyuki; Lane, Adam; Kalfa, Theodosia A; Malik, Punam; Quinn, Charles T; Ware, Russell E; Vinks, Alexander A 2019. Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia. American journal of hematology, 94 8, 871-879Mehta, Parinda A; Emoto, Chie; Fukuda, Tsuyoshi; Seyboth, Brian; Teusink-Cross, Ashley; Davies, Stella M; Wilhelm, Jamie; Fuller, Kirsten; Vinks, Alexander A; Boulad, Farid 2019. Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different? Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 25 12, 2416-2421Mizuno, Tomoyuki; Gist, Katja M; Gao, Zhiqian; Wempe, Michael F; Alten, Jeffrey; Cooper, David S; Goldstein, Stuart L; Vinks, Alexander A 2019. Developmental Pharmacokinetics and Age-Appropriate Dosing Design of Milrinone in Neonates and Infants with Acute Kidney Injury Following Cardiac Surgery. Clinical pharmacokinetics, 58 6, 793-803Mizuno, Tomoyuki; O'Brien, Maureen M; Vinks, Alexander A 2019. Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128 , 209-214Ramsey, Laura B; Mizuno, Tomoyuki; Vinks, Alexander A; O'Brien, Maureen M 2019. Delayed methotrexate clearance in patients with acute lymphoblastic leukemia concurrently receiving dasatinib. Pediatric blood & cancer, 66 5, e27618Ramsey, Laura B; Prows, Cynthia A; Zhang, Kejian; Saldaña, Shannon N; Sorter, Michael T; Pestian, John P; Wenstrup, Richard J; Vinks, Alexander A; Glauser, Tracy A 2019. Implementation of Pharmacogenetics at Cincinnati Children's Hospital Medical Center: Lessons Learned Over 14 Years of Personalizing Medicine. Clinical pharmacology and therapeutics, 105 1, 49-52Soul, Janet S; Pressler, Ronit; Allen, Marilee; Boylan, Geraldine; Rabe, Heike; Portman, Ron; Hardy, Pollyanna; Zohar, Sarah; Romero, Klaus; Tseng, Brian; Bhatt-Mehta, Varsha; Hahn, Cecil; Denne, Scott; Auvin, Stephane; Vinks, Alexander; Lantos, John; Marlow, Neil; Davis, Jonathan M 2019. Recommendations for the design of therapeutic trials for neonatal seizures. Pediatric research, 85 7, 943-954Tang Girdwood, Sonya C; Mizuno, Tomoyuki; Krallman, Kelli A; Benken, Laura A; Stoneman, Erin M; Yunger, Toni M; Wong, Hector R; Vinks, Alexander A; Kaplan, Jennifer M 2019. Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children. The Pediatric infectious disease journal, 38 12, 1224-1227Vinks, Alexander A 2019. From Molecule to Patient and Ways to Get the Dose Precisely Right. Clinical pharmacology and therapeutics, 105 3, 534-537Berry, Susan A; Vockley, Jerry; Vinks, Alexander A; Dong, Min; Diaz, George A; McCandless, Shawn E; Smith, Wendy E; Harding, Cary O; Zori, Roberto; Ficicioglu, Can; Lichter-Konecki, Uta; Perdok, Renee; Robinson, Beth; Holt, Robert J; Longo, Nicola 2018. Pharmacokinetics of glycerol phenylbutyrate in pediatric patients 2 months to 2 years of age with urea cycle disorders. Molecular genetics and metabolism, 125 3, 251-257Chandra, Sharat; Fukuda, Tsuyoshi; Mizuno, Kana; Davies, Stella M; Teusink-Cross, Ashley; Tarin, Rich; Marsh, Rebecca A; Vinks, Alexander A; Mehta, Parinda A 2018. Micafungin antifungal prophylaxis in children undergoing HSCT: can we give higher doses, less frequently? A pharmacokinetic study. The Journal of antimicrobial chemotherapy, 73 6, 1651-1658Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2018. Model-based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management. British journal of clinical pharmacology, 84 7, 1410-1412Emoto, Chie; Johnson, Trevor N; McPhail, Brooks T; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. Using a Vancomycin PBPK Model in Special Populations to Elucidate Case-Based Clinical PK Observations. CPT: pharmacometrics & systems pharmacology, 7 4, 237-250Emoto, Chie; Johnson, Trevor N; Neuhoff, Sibylle; Hahn, David; Vinks, Alexander A; Fukuda, Tsuyoshi 2018. PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants. CPT: pharmacometrics & systems pharmacology, 7 7, 464-473Farag, Elmoubasher; Sikkema, Reina S; Vinks, Tinka; Islam, Md Mazharul; Nour, Mohamed; Al-Romaihi, Hamad; Al Thani, Mohammed; Atta, Muzzamil; Alhajri, Farhoud H; Al-Marri, Salih; AlHajri, Mohd; Reusken, Chantal; Koopmans, Marion 2018. Drivers of MERS-CoV Emergence in Qatar. Viruses, 11 1, Gist, Katja M; Cooper, David S; Wrona, Julia; Faubel, Sarah; Altmann, Christopher; Gao, Zhiqian; Marino, Bradley S; Alten, Jeffrey; Hock, Kristal M; Mizuno, Tomoyuki; Vinks, Alexander A; Joy, Melanie S; Wempe, Michael F; Bennett, Michael R; Goldstein, Stuart L 2018. Acute Kidney Injury Biomarkers Predict an Increase in Serum Milrinone Concentration Earlier Than Serum Creatinine-Defined Acute Kidney Injury in Infants After Cardiac Surgery. Therapeutic drug monitoring, 40 2, 186-194Kaplan, Jennifer M; Zingarelli, Basilia; Krallman, Kelli; Tang Girdwood, Sonya; Lagory, Denise; Mizuno, Tomoyuki; Fei, Lin; Wong, Hector R; Vinks, Alexander A 2018. Phase 1 safety and pharmacokinetic study on the use of pioglitazone in critically ill patients with sepsis: a randomized clinical trial. Intensive care medicine, 44 11, 2006-2008Miller, J W; Balyan, R; Dong, M; Mahmoud, M; Lam, J E; Pratap, J N; Paquin, J R; Li, B L; Spaeth, J P; Vinks, A; Loepke, A W 2018. Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study. British journal of anaesthesia, 120 5, 1056-1065Mizuno, Kana; Dong, Min; Fukuda, Tsuyoshi; Chandra, Sharat; Mehta, Parinda A; McConnell, Scott; Anaissie, Elias J; Vinks, Alexander A 2018. Population Pharmacokinetics and Optimal Sampling Strategy for Model-Based Precision Dosing of Melphalan in Patients Undergoing Hematopoietic Stem Cell Transplantation. Clinical pharmacokinetics, 57 5, 625-636Ramsey, Laura B; Balis, Frank M; O'Brien, Maureen M; Schmiegelow, Kjeld; Pauley, Jennifer L; Bleyer, Archie; Widemann, Brigitte C; Askenazi, David; Bergeron, Sharon; Shirali, Anushree; Schwartz, Stefan; Vinks, Alexander A; Heldrup, Jesper 2018. Consensus Guideline for Use of Glucarpidase in Patients with High-Dose Methotrexate Induced Acute Kidney Injury and Delayed Methotrexate Clearance. The oncologist, 23 1, 52-61Alloway, Rita R; Vinks, Alexander A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; King, Eileen C; Zou, Yuanshu; Jiang, Wenlei; Woodle, E Steve; Tremblay, Simon; Klawitter, Jelena; Klawitter, Jost; Christians, Uwe 2017. Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial. PLoS medicine, 14 11, e1002428Balyan, Rajiv; Mecoli, Marc; Venkatasubramanian, Raja; Chidambaran, Vidya; Kamos, Nichole; Clay, Smokey; Moore, David L; Mavi, Jagroop; Glover, Chris D; Szmuk, Peter; Vinks, Alexander; Sadhasivam, Senthilkumar 2017. CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients. Pharmacogenomics, 18 4, 337-348Balyan, Rajiv; Zhang, Xue; Chidambaran, Vidya; Martin, Lisa J; Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Vinks, Alexander A; Sadhasivam, Senthilkumar 2017. OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children. Pharmacogenomics, 18 7, 621-629Cabrera-Salcedo, Catalina; Mizuno, Tomoyuki; Tyzinski, Leah; Andrew, Melissa; Vinks, Alexander A; Frystyk, Jan; Wasserman, Halley; Gordon, Catherine M; Hwa, Vivian; Backeljauw, Philippe; Dauber, Andrew 2017. Pharmacokinetics of IGF-1 in PAPP-A2-Deficient Patients, Growth Response, and Effects on Glucose and Bone Density. The Journal of clinical endocrinology and metabolism, 102 12, 4568-4577Chidambaran, V; Venkatasubramanian, R; Zhang, X; Martin, L J; Niu, J; Mizuno, T; Fukuda, T; Meller, J; Vinks, A A; Sadhasivam, S 2017. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. The pharmacogenomics journal, 17 2, 162-169Chidambaran, Vidya; Pilipenko, Valentina; Spruance, Kristie; Venkatasubramanian, Raja; Niu, Jing; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Zhang, Kejian; Kaufman, Kenneth; Vinks, Alexander A; Martin, Lisa J; Sadhasivam, Senthilkumar 2017. Fatty acid amide hydrolase-morphine interaction influences ventilatory response to hypercapnia and postoperative opioid outcomes in children. Pharmacogenomics, 18 2, 143-156Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; Reny, J-L; Marsousi, N; Daali, Y; Fairman, D; Cook, J; Lesko, L J; McCune, J S; Knibbe, Caj; de Wildt, S N; Leeder, J S; Neely, M; Zuppa, A F; Vicini, P; Aarons, L; Johnson, T N; Boiani, J; Rostami-Hodjegan, A 2017. Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future. Clinical pharmacology and therapeutics, 101 5, 646-656Diwan, Tayyab S; Lichvar, Alicia B; Leino, Abbie D; Vinks, Alexander A; Christians, Uwe; Shields, Adele R; Cardi, Michael A; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Kaiser, Tiffany; Woodle, E Steve; Alloway, Rita R 2017. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clinical transplantation, 31 6, Dong, Min; Fukuda, Tsuyoshi; Selim, Sally; Smith, Mark A; Rabinovich-Guilatt, Laura; Cassella, James V; Vinks, Alexander A 2017. Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents. Clinical pharmacokinetics, 56 10, 1207-1217Dong, Min; Mizuno, Tomoyuki; Vinks, Alexander A 2017. Opportunities for model-based precision dosing in the treatment of sickle cell anemia. Blood cells, molecules & diseases, 67 , 143-147Downes, Kevin J; Dong, Min; Fukuda, Tsuyoshi; Clancy, John P; Haffner, Christopher; Bennett, Michael R; Vinks, Alexander A; Goldstein, Stuart L 2017. Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis. The Journal of antimicrobial chemotherapy, 72 1, 254-260Emoto, C; Fukuda, T; Johnson, T N; Neuhoff, S; Sadhasivam, S; Vinks, A A 2017. Characterization of Contributing Factors to Variability in Morphine Clearance Through PBPK Modeling Implemented With OCT1 Transporter. CPT: pharmacometrics & systems pharmacology, 6 2, 110-119Faircloth, Jenna M; Miner, Kristin M; Alsaied, Tarek; Nelson, Nicole; Ciambarella, Julie; Mizuno, Tomoyuki; Palumbo, Joseph S; Vinks, Alexander A; Veldtman, Gruschen R 2017. Time in therapeutic range as a marker for thrombotic and bleeding outcomes in Fontan patients. Journal of thrombosis and thrombolysis, 44 1, 38-47Faircloth, Jenna M; Roe, Olivia; Alsaied, Tarek; Palumbo, Joseph S; Vinks, Alexander; Veldtman, Gruschen R 2017. Intermediate term thrombotic risk in contemporary total cavo-pulmonary connection for single ventricle circulations. Journal of thrombosis and thrombolysis, 44 3, 275-280Hahn, David; Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2017. Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children. Drug metabolism and disposition: the biological fate of chemicals, 45 1, 23-26Marsh, Rebecca A; Fukuda, Tsuyoshi; Emoto, Chie; Neumeier, Lisa; Khandelwal, Pooja; Chandra, Sharat; Teusink-Cross, Ashley; Vinks, Alexander A; Mehta, Parinda A 2017. Pretransplant Absolute Lymphocyte Counts Impact the Pharmacokinetics of Alemtuzumab. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 23 4, 635-641Mizuno, Tomoyuki; Emoto, Chie; Fukuda, Tsuyoshi; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 109S , S124-S131Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Christians, Uwe; Perentesis, John P; Fouladi, Maryam; Vinks, Alexander A 2017. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. British journal of clinical pharmacology, 83 5, 1097-1107Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Emoto, Chie; Mobberley-Schuman, Paula S; Hammill, Adrienne M; Adams, Denise M; Vinks, Alexander A 2017. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatric blood & cancer, 64 8, Ramsey, L B; Mizuno, T; Vinks, A A; Margolis, P A 2017. Learning Health Systems as Facilitators of Precision Medicine. Clinical pharmacology and therapeutics, 101 3, 359-367Rohan, Jennifer M; Fukuda, Tsuyoshi; Alderfer, Melissa A; Wetherington Donewar, Crista; Ewing, Linda; Katz, Ernest R; Muriel, Anna C; Vinks, Alexander A; Drotar, Dennis 2017. Measuring Medication Adherence in Pediatric Cancer: An Approach to Validation. Journal of pediatric psychology, 42 2, 232-244Selim, Sally; Riesenberg, Robert; Cassella, James; Kunta, Jeevan; Hellriegel, Edward; Smith, Mark A; Vinks, Alexander A; Rabinovich-Guilatt, Laura 2017. Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents. Journal of clinical pharmacology, 57 10, 1244-1257Varnell, Charles D; Fukuda, Tsuyoshi; Kirby, Cassie L; Martin, Lisa J; Warshaw, Barry L; Patel, Hiren P; Chand, Deepa H; Barletta, Gina-Marie; Van Why, Scott K; VanDeVoorde, Rene G; Weaver, Donald J; Wilson, Amy; Verghese, Priya S; Vinks, Alexander A; Greenbaum, Larry A; Goebel, Jens; Hooper, David K 2017. Mycophenolate mofetil-related leukopenia in children and young adults following kidney transplantation: Influence of genes and drugs. Pediatric transplantation, 21 7, Vinks, A A 2017. Precision Medicine-Nobody Is Average. Clinical pharmacology and therapeutics, 101 3, 304-307Xiong, Ye; Fukuda, Tsuyoshi; Knibbe, Catherijne A J; Vinks, Alexander A 2017. Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies. Pediatric clinics of North America, 64 6, 1417-1438Yu, Tian; Enioutina, Elena Y; Brunner, Hermine I; Vinks, Alexander A; Sherwin, Catherine M 2017. Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clinical pharmacokinetics, 56 2, 107-125Adams, Denise M; Trenor, Cameron C; Hammill, Adrienne M; Vinks, Alexander A; Patel, Manish N; Chaudry, Gulraiz; Wentzel, Mary Sue; Mobberley-Schuman, Paula S; Campbell, Lisa M; Brookbank, Christine; Gupta, Anita; Chute, Carol; Eile, Jennifer; McKenna, Jesse; Merrow, Arnold C; Fei, Lin; Hornung, Lindsey; Seid, Michael; Dasgupta, A Roshni; Dickie, Belinda H; Elluru, Ravindhra G; Lucky, Anne W; Weiss, Brian; Azizkhan, Richard G 2016. Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies. Pediatrics, 137 2, e20153257Arya, Ravindra; Gillespie, Catherine W; Cnaan, Avital; Devarajan, Mahima; Clark, Peggy; Shinnar, Shlomo; Vinks, Alexander A; Mizuno, Kana; Glauser, Tracy A 2016. Obesity and overweight as CAE comorbidities and differential drug response modifiers. Neurology, 86 17, 1613-21Cvijanovich, Natalie Z; King, Janet C; Flori, Heidi R; Gildengorin, Ginny; Vinks, Alexander A; Wong, Hector R 2016. Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness. JPEN. Journal of parenteral and enteral nutrition, 40 6, 860-8Dong, Min; McGann, Patrick T; Mizuno, Tomoyuki; Ware, Russell E; Vinks, Alexander A 2016. Development of a pharmacokinetic-guided dose individualization strategy for hydroxyurea treatment in children with sickle cell anaemia. British journal of clinical pharmacology, 81 4, 742-52Downes, Kevin J; Goldstein, Stuart L; Vinks, Alexander A 2016. Increased Vancomycin Exposure and Nephrotoxicity in Children: Therapeutic Does Not Mean Safe. Journal of the Pediatric Infectious Diseases Society, 5 1, 65-7Emoto, C; Fukuda, T; Mizuno, T; Schniedewind, B; Christians, Uwe; Adams, D M; Vinks, A A 2016. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 5 8, 411-7Emoto, Chie; Vinks, Alexander A; Fukuda, Tsuyoshi 2016. Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. Therapeutic drug monitoring, 38 5, 607-13Gist, Katja M; Goldstein, Stuart L; Joy, Melanie S; Vinks, Alexander A 2016. Milrinone Dosing Issues in Critically Ill Children With Kidney Injury: A Review. Journal of cardiovascular pharmacology, 67 2, 175-81Hahn, Andrea; Fukuda, Tsuyoshi; Hahn, David; Mizuno, Tomoyuki; Frenck, Robert W; Vinks, Alexander A 2016. Pharmacokinetics and pharmacogenomics of β-lactam-induced neutropenia. Pharmacogenomics, 17 6, 547-59Jodele, Sonata; Fukuda, Tsuyoshi; Mizuno, Kana; Vinks, Alexander A; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Chima, Ranjit S; Hirsch, Russel; Teusink, Ashley; Lazear, Danielle; Lane, Adam; Myers, Kasiani C; Dandoy, Christopher E; Davies, Stella M 2016. Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 2, 307-315Khandelwal, Pooja; Emoto, Chie; Fukuda, Tsuyoshi; Vinks, Alexander A; Neumeier, Lisa; Dandoy, Christopher E; El-Bietar, Javier; Chandra, Sharat; Davies, Stella M; Bleesing, Jacob J; Jordan, Michael B; Mehta, Parinda A; Jodele, Sonata; Grimley, Michael S; Kumar, Ashish; Myers, Kasiani C; Marsh, Rebecca A 2016. A Prospective Study of Alemtuzumab as a Second-Line Agent for Steroid-Refractory Acute Graft-versus-Host Disease in Pediatric and Young Adult Allogeneic Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 12, 2220-2225Khandelwal, Pooja; Fukuda, Tsuyoshi; Mizuno, Kana; Teusink-Cross, Ashley; Mehta, Parinda A; Marsh, Rebecca A; Kashuba, Angela D M; Vinks, Alexander A; Davies, Stella M 2016. A Pharmacokinetic and Pharmacodynamic Study of Maraviroc as Acute Graft-versus-Host Disease Prophylaxis in Pediatric Allogeneic Stem Cell Transplant Recipients with Nonmalignant Diagnoses. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 10, 1829-1835Nehus, Edward J; Mizuno, Tomoyuki; Cox, Shareen; Goldstein, Stuart L; Vinks, Alexander A 2016. Pharmacokinetics of meropenem in children receiving continuous renal replacement therapy: Validation of clinical trial simulations. Journal of clinical pharmacology, 56 3, 291-7Ngamprasertwong, Pornswan; Dong, Min; Niu, Jing; Venkatasubramanian, Raja; Vinks, Alexander A; Sadhasivam, Senthilkumar 2016. Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model. PloS one, 11 1, e0146563Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2016. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1-Erratum. Therapeutic drug monitoring, 38 2, 284Teusink, Ashley; Vinks, Alexander; Zhang, Kejian; Davies, Stella; Fukuda, Tsuyoshi; Lane, Adam; Nortman, Shannon; Kissell, Diane; Dell, Sarah; Filipovich, Alexandra; Mehta, Parinda 2016. Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 22 3, 482-6Vinks, Alexander A 2016. Therapeutic Optimization as Part of the Precision Medicine Paradigm. Clinical pharmacology and therapeutics, 99 4, 340-2Birdwell, K A; Decker, B; Barbarino, J M; Peterson, J F; Stein, C M; Sadee, W; Wang, D; Vinks, A A; He, Y; Swen, J J; Leeder, J S; van Schaik, Rhn; Thummel, K E; Klein, T E; Caudle, K E; MacPhee, I A M 2015. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical pharmacology and therapeutics, 98 1, 19-24Brouwer, K L R; Aleksunes, L M; Brandys, B; Giacoia, G P; Knipp, G; Lukacova, V; Meibohm, B; Nigam, S K; Rieder, M; de Wildt, S N 2015. Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical pharmacology and therapeutics, 98 3, 266-87Chidambaran, Vidya; Venkatasubramanian, Raja; Sadhasivam, Senthilkumar; Esslinger, Hope; Cox, Shareen; Diepstraten, Jeroen; Fukuda, Tsuyoshi; Inge, Thomas; Knibbe, Catherijne A J; Vinks, Alexander A 2015. Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. Paediatric anaesthesia, 25 9, 911-923Christians, Uwe; Vinks, Alexander A; Langman, Loralie J; Clarke, William; Wallemacq, Pierre; van Gelder, Teun; Renjen, Varun; Marquet, Pierre; Meyer, Eric J 2015. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Therapeutic drug monitoring, 37 6, 718-24Emoto, C; Fukuda, T; Johnson, T N; Adams, D M; Vinks, A A 2015. Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants. CPT: pharmacometrics & systems pharmacology, 4 2, e17Emoto, Chie; Fukuda, Tsuyoshi; Mizuno, Tomoyuki; Cox, Shareen; Schniedewind, Björn; Christians, Uwe; Widemann, Brigitte C; Fisher, Michael J; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2015. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Therapeutic drug monitoring, 37 3, 395-9Emoto, Chie; Fukuda, Tsuyoshi; Venkatasubramanian, Raja; Vinks, Alexander A 2015. The impact of CYP3A5*3 polymorphism on sirolimus pharmacokinetics: insights from predictions with a physiologically-based pharmacokinetic model. British journal of clinical pharmacology, 80 6, 1438-46Fouladi, Maryam; Perentesis, John P; Wagner, Lars M; Vinks, Alexander A; Reid, Joel M; Ahern, Charlotte; Thomas, George; Mercer, Carol A; Krueger, Darcy A; Houghton, Peter J; Doyle, L Austin; Chen, Helen; Weigel, Brenda; Blaney, Susan M 2015. A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 7, 1558-65Gist, Katja M; Mizuno, Tomoyuki; Goldstein, Stuart L; Vinks, Alexander 2015. Retrospective Evaluation of Milrinone Pharmacokinetics in Children With Kidney Injury. Therapeutic drug monitoring, 37 6, 792-6Hahn, Andrea; Frenck, Robert W; Allen-Staat, Mary; Zou, Yuanshu; Vinks, Alexander A 2015. Evaluation of Target Attainment of Vancomycin Area Under the Curve in Children With Methicillin-Resistant Staphylococcus Aureus Bacteremia. Therapeutic drug monitoring, 37 5, 619-25Hahn, Andrea; Frenck, Robert W; Zou, Yuanshu; Vinks, Alexander A 2015. Validation of a pediatric population pharmacokinetic model for vancomycin. Therapeutic drug monitoring, 37 3, 413-6Rosen, M J; Minar, P; Vinks, A A 2015. Letter: stool adalimumab detection in ulcerative colitis and Crohn's disease--authors' reply. Alimentary pharmacology & therapeutics, 42 2, 241Rosen, M J; Minar, P; Vinks, A A 2015. Review article: applying pharmacokinetics to optimise dosing of anti-TNF biologics in acute severe ulcerative colitis. Alimentary pharmacology & therapeutics, 41 11, 1094-103Shinnar, Shlomo; Cnaan, Avital; Hu, Fengming; Clark, Peggy; Dlugos, Dennis; Hirtz, Deborah G; Masur, David; Mizrahi, Eli M; Moshé, Solomon L; Glauser, Tracy A 2015. Long-term outcomes of generalized tonic-clonic seizures in a childhood absence epilepsy trial. Neurology, 85 13, 1108-14Shokati, Touraj; Bodenberger, Nicholas; Gadpaille, Holly; Schniedewind, Björn; Vinks, Alexander A; Jiang, Wenlei; Alloway, Rita R; Christians, Uwe 2015. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. Journal of visualized experiments : JoVE, 105, e52424Vinks, A A; Emoto, C; Fukuda, T 2015. Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children. Clinical pharmacology and therapeutics, 98 3, 298-308Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander; Cantor, Alan; Perentesis, John; Schorry, Elizabeth; Ullrich, Nicole; Gutmann, David H; Tonsgard, James; Viskochil, David; Korf, Bruce; Packer, Roger J; Fisher, Michael J 2015. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro-oncology, 17 4, 596-603Wiles, Jason R; Isemann, Barbara; Mizuno, Tomoyuki; Tabangin, Meredith E; Ward, Laura P; Akinbi, Henry; Vinks, Alexander A 2015. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. The Journal of pediatrics, 167 6, 1214-20.e3Yang, Xiaoyan; Sherwin, Catherine M T; Yu, Tian; Yellepeddi, Venkata K; Brunner, Hermine I; Vinks, Alexander A 2015. Pharmacokinetic modeling of therapies for systemic lupus erythematosus. Expert review of clinical pharmacology, 8 5, 587-603Dong, Min; Fukuda, Tsuyoshi; Cox, Shareen; de Vries, Marij T; Hooper, David K; Goebel, Jens; Vinks, Alexander A 2014. Population pharmacokinetic-pharmacodynamic modelling of mycophenolic acid in paediatric renal transplant recipients in the early post-transplant period. British journal of clinical pharmacology, 78 5, 1102-12Dong, Min; Fukuda, Tsuyoshi; Vinks, Alexander A 2014. Optimization of mycophenolic acid therapy using clinical pharmacometrics. Drug metabolism and pharmacokinetics, 29 1, 4-11Downes, Kevin J; Hahn, Andrea; Wiles, Jason; Courter, Joshua D; Vinks, Alexander A 2014. Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics. International journal of antimicrobial agents, 43 3, 223-30Filler, Guido; Vinks, Alexander A; Huang, Shih-Han S; Jevnikar, Anthony; Muirhead, Norman 2014. Similar MPA exposure on modified release and regular tacrolimus. Therapeutic drug monitoring, 36 3, 353-7Jarvik, Gail P; Amendola, Laura M; Berg, Jonathan S; Brothers, Kyle; Clayton, Ellen W; Chung, Wendy; Evans, Barbara J; Evans, James P; Fullerton, Stephanie M; Gallego, Carlos J; Garrison, Nanibaa' A; Gray, Stacy W; Holm, Ingrid A; Kullo, Iftikhar J; Lehmann, Lisa Soleymani; McCarty, Cathy; Prows, Cynthia A; Rehm, Heidi L; Sharp, Richard R; Salama, Joseph; Sanderson, Saskia; Van Driest, Sara L; Williams, Marc S; Wolf, Susan M; Wolf, Wendy A ; Burke, Wylie 2014. Return of genomic results to research participants: the floor, the ceiling, and the choices in between. American journal of human genetics, 94 6, 818-26Jodele, Sonata; Fukuda, Tsuyoshi; Vinks, Alexander; Mizuno, Kana; Laskin, Benjamin L; Goebel, Jens; Dixon, Bradley P; Teusink, Ashley; Pluthero, Fred G; Lu, Lily; Licht, Christoph; Davies, Stella M 2014. Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20 4, 518-25Mizuno, Tomoyuki; Fukuda, Tsuyoshi; Masuda, Satohiro; Uemoto, Shinji; Matsubara, Kazuo; Inui, Ken-Ichi; Vinks, Alexander A 2014. Developmental trajectory of intestinal MDR1/ABCB1 mRNA expression in children. British journal of clinical pharmacology, 77 5, 910-2Mizuno, Tomoyuki; Fukudo, Masahide; Fukuda, Tsuyoshi; Terada, Tomohiro; Dong, Min; Kamba, Tomomi; Yamasaki, Toshinari; Ogawa, Osamu; Katsura, Toshiya; Inui, Ken-Ichi; Vinks, Alexander A; Matsubara, Kazuo 2014. The effect of ABCG2 genotype on the population pharmacokinetics of sunitinib in patients with renal cell carcinoma. Therapeutic drug monitoring, 36 3, 310-6Nehus, Edward J; Mouksassi, Samer; Vinks, Alexander A; Goldstein, Stuart 2014. Meropenem in children receiving continuous renal replacement therapy: clinical trial simulations using realistic covariates. Journal of clinical pharmacology, 54 12, 1421-8Rasmussen-Torvik, L J; Stallings, S C; Gordon, A S; Almoguera, B; Basford, M A; Bielinski, S J; Brautbar, A; Brilliant, M H; Carrell, D S; Connolly, J J; Crosslin, D R; Doheny, K F; Gallego, C J; Gottesman, O; Kim, D S; Leppig, K A; Li, R; Lin, S; Manzi, S; Mejia, A R; Pacheco, J A; Pan, V; Pathak, J; Perry, C L; Peterson, J F; Prows, C A; Ralston, J; Rasmussen, L V; Ritchie, M D; Sadhasivam, S; Scott, S A; Smith, M; Vega, A; Vinks, A A; Volpi, S; Wolf, W A; Bottinger, E; Chisholm, R L; Chute, C G; Haines, J L; Harley, J B; Keating, B; Holm, I A; Kullo, I J; Jarvik, G P; Larson, E B; Manolio, T; McCarty, C A; Nickerson, D A; Scherer, S E; Williams, M S; Roden, D M; Denny, J C 2014. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clinical pharmacology and therapeutics, 96 4, 482-9Roberts, Jason A; Abdul-Aziz, Mohd H; Lipman, Jeffrey; Mouton, Johan W; Vinks, Alexander A; Felton, Timothy W; Hope, William W; Farkas, Andras; Neely, Michael N; Schentag, Jerome J; Drusano, George; Frey, Otto R; Theuretzbacher, Ursula; Kuti, Joseph L 2014. Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. The Lancet. Infectious diseases, 14 6, 498-509Sherwin, Catherine M T; Ngamprasertwong, Pornswan; Sadhasivam, Senthilkumar; Vinks, Alexander A 2014. Utilization of optimal study design for maternal and fetal sheep propofol pharmacokinetics study: a preliminary study. Current clinical pharmacology, 9 1, 64-9Smits, Thomas A; Cox, Shareen; Fukuda, Tsuyoshi; Sherbotie, Joseph R; Ward, Robert M; Goebel, Jens; Vinks, Alexander A 2014. Effects of unbound mycophenolic acid on inosine monophosphate dehydrogenase inhibition in pediatric kidney transplant patients. Therapeutic drug monitoring, 36 6, 716-23Venkatasubramanian, Raja; Fukuda, Tsuyoshi; Niu, Jing; Mizuno, Tomoyuki; Chidambaran, Vidya; Vinks, Alexander A; Sadhasivam, Senthilkumar 2014. ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children. Pharmacogenomics, 15 10, 1297-309Weiss, Brian; Widemann, Brigitte C; Wolters, Pamela; Dombi, Eva; Vinks, Alexander A; Cantor, Alan; Korf, Bruce; Perentesis, John; Gutmann, David H; Schorry, Elizabeth; Packer, Roger; Fisher, Michael J 2014. Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatric blood & cancer, 61 6, 982-6Wiles, Jason R; Isemann, Barbara; Ward, Laura P; Vinks, Alexander A; Akinbi, Henry 2014. Current management of neonatal abstinence syndrome secondary to intrauterine opioid exposure. The Journal of pediatrics, 165 3, 440-6Chidambaran, Vidya; Sadhasivam, Senthilkumar; Diepstraten, Jeroen; Esslinger, Hope; Cox, Shareen; Schnell, Beverly M; Samuels, Paul; Inge, Thomas; Vinks, Alexander A; Knibbe, Catherijne A 2013. Evaluation of propofol anesthesia in morbidly obese children and adolescents. BMC anesthesiology, 13 , 8Diepstraten, J; Chidambaran, V; Sadhasivam, S; Blussé van Oud-Alblas, H J; Inge, T; van Ramshorst, B; van Dongen, E P A; Vinks, A A; Knibbe, C A J 2013. An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children. CPT: pharmacometrics & systems pharmacology, 2 9, e73Emoto, C; Fukuda, T; Cox, S; Christians, U; Vinks, A A 2013. Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. CPT: pharmacometrics & systems pharmacology, 2 7, e59Fukuda, Tsuyoshi; Chidambaran, Vidya; Mizuno, Tomoyuki; Venkatasubramanian, Raja; Ngamprasertwong, Pornswan; Olbrecht, Vanessa; Esslinger, Hope R; Vinks, Alexander A; Sadhasivam, Senthilkumar 2013. OCT1 genetic variants influence the pharmacokinetics of morphine in children. Pharmacogenomics, 14 10, 1141-51Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Adamson, Peter C 2013. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months. Epilepsia, 54 1, 141-55Gottesman, Omri; Kuivaniemi, Helena; Tromp, Gerard; Faucett, W Andrew; Li, Rongling; Manolio, Teri A; Sanderson, Saskia C; Kannry, Joseph; Zinberg, Randi; Basford, Melissa A; Brilliant, Murray; Carey, David J; Chisholm, Rex L; Chute, Christopher G; Connolly, John J; Crosslin, David; Denny, Joshua C; Gallego, Carlos J; Haines, Jonathan L; Hakonarson, Hakon; Harley, John; Jarvik, Gail P; Kohane, Isaac; Kullo, Iftikhar J; Larson, Eric B; McCarty, Catherine; Ritchie, Marylyn D; Roden, Dan M; Smith, Maureen E; Böttinger, Erwin P; Williams, Marc S 2013. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in medicine : official journal of the American College of Medical Genetics, 15 10, 761-71Hahn, Andrea; Vinks, Alexander A 2013. Lower vancomycin serum trough concentrations might not be the answer. The Pediatric infectious disease journal, 32 12, 1403-4Pian, Phillip; Labovitz, Edward; Hoffman, Keith; Clavijo, Claudia F; Rzasa Lynn, Rachael; Galinkin, Jeffrey L; Vinks, Alexander A; Malik, Punam; Christians, Uwe 2013. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 937 , 79-83Scott, Jeffrey R; Courter, Joshua D; Saldaña, Shannon N; Widemann, Brigitte C; Fisher, Michael; Weiss, Brian; Perentesis, John; Vinks, Alexander A 2013. Population pharmacokinetics of sirolimus in pediatric patients with neurofibromatosis type 1. Therapeutic drug monitoring, 35 3, 332-7Vinks, A A 2013. The future of physiologically based pharmacokinetic modeling to predict drug exposure in pregnant women. CPT: pharmacometrics & systems pharmacology, 2 3, e33Wang, Chenguang; Sadhavisvam, Senthilkumar; Krekels, Elke H J; Dahan, Albert; Tibboel, Dick; Danhof, Meindert; Vinks, Alexander A; Knibbe, Catherijne A J 2013. Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model. Clinical drug investigation, 33 7, 523-34Abdel-Rahman, Susan M; Amidon, Gordon L; Kaul, Ajay; Lukacova, Viera; Vinks, Alexander A; Knipp, Gregory T 2012. Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group. Clinical therapeutics, 34 11, S11-24Cattaneo, Dario; Vinks, Alexander A 2012. Optimizing immunosuppressive drug dosing in pediatric renal transplantation. Part of a special series on Paediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni. Pharmacological research, 65 2, 163-7Chidambaran, Vidya; Ngamprasertwong, Pornswan; Vinks, Alexander A; Sadhasivam, Senthilkumar 2012. Pharmacogenetics and anesthetic drugs. Current clinical pharmacology, 7 2, 78-101Cohen, Mindy; Sadhasivam, Senthilkumar; Vinks, Alexander A 2012. Pharmacogenetics in perioperative medicine. Current opinion in anaesthesiology, 25 4, 419-27Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size. Clinical pharmacokinetics, 51 8, 543-551Diepstraten, Jeroen; Chidambaran, Vidya; Sadhasivam, Senthilkumar; Esslinger, Hope R; Cox, Shareen L; Inge, Thomas H; Knibbe, Catherijne A J; Vinks, Alexander A 2012. Propofol clearance in morbidly obese children and adolescents: influence of age and body size. Clinical pharmacokinetics, 51 8, 543-51Fukuda, Tsuyoshi; Goebel, Jens; Cox, Shareen; Maseck, Denise; Zhang, Kejian; Sherbotie, Joseph R; Ellis, Eileen N; James, Laura P; Ward, Robert M; Vinks, Alexander A 2012. UGT1A9, UGT2B7, and MRP2 Genotypes Can Predict Mycophenolic Acid Pharmacokinetic Variability in Pediatric Kidney Transplant Recipients. Therapeutic drug monitoring, 34 6, 671-679Hooper, David K; Fukuda, Tsuyoshi; Gardiner, Rhonda; Logan, Barbara; Roy-Chaudhury, Ashwini; Kirby, Cassie L; Vinks, Alexander A; Goebel, Jens 2012. Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation. Transplantation, 93 8, 806-12Ngamprasertwong, Pornswan; Vinks, Alexander A; Boat, Anne 2012. Update in Fetal Anesthesia for the Ex Utero Intrapartum Treatment (EXIT) Procedure. International anesthesiology clinics, 50 4, 26-40Sherwin, Catherine M T; Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Brunner, Hermine I; Vinks, Alexander A 2012. Development of population PK model with enterohepatic circulation for mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. British journal of clinical pharmacology, 73 5, 727-40Sherwin, Catherine M T; Saldaña, Shannon N; Bies, Robert R; Aman, Michael G; Vinks, Alexander A 2012. Population pharmacokinetic modeling of risperidone and 9-hydroxyrisperidone to estimate CYP2D6 subpopulations in children and adolescents. Therapeutic drug monitoring, 34 5, 535-44Wiles, Jason R; Vinks, Alexander A; Akinbi, Henry 2012. Federal Legislation and the Advancement of Neonatal Drug Studies. The Journal of pediatrics, , Brandhorst, Gunnar; Oellerich, Michael; Brunet, Mercè; Kowalski, Richard; Vinks, Alexander; Wallemacq, Pierre 2011. Individually tailored immunosuppression: is there a role for biomarkers? Clinical chemistry, 57 3, 376-81Fukuda, Tsuyoshi; Brunner, Hermine I; Sagcal-Gironella, Anna Carmela P; Vinks, Alexander A 2011. Nonsteroidal anti-inflammatory drugs may reduce enterohepatic recirculation of mycophenolic acid in patients with childhood-onset systemic lupus erythematosus. Therapeutic drug monitoring, 33 5, 658-62Fukuda, Tsuyoshi; Goebel, Jens; Thøgersen, Håvard; Maseck, Denise; Cox, Shareen; Logan, Barbara; Sherbotie, Joseph; Seikaly, Mouin; Vinks, Alexander A 2011. Inosine monophosphate dehydrogenase (IMPDH) activity as a pharmacodynamic biomarker of mycophenolic acid effects in pediatric kidney transplant recipients. Journal of clinical pharmacology, 51 3, 309-20Li, Zhiping; Wang, Li; Wang, Yi; Gui, Yonghao H; Vinks, Alexander A; MacLeod, Stuart 2011. Better medicines for 300 million children in China: report on recent progress. Paediatric drugs, 13 3, 137-40Merhar, Stephanie L; Schibler, Kurt R; Sherwin, Catherine M; Meinzen-Derr, Jareen; Shi, Jing; Balmakund, Tonya; Vinks, Alexander A 2011. Pharmacokinetics of levetiracetam in neonates with seizures. The Journal of pediatrics, 159 1, 152-154.e3Sagcal-Gironella, Anna Carmela P; Fukuda, Tsuyoshi; Wiers, Kristina; Cox, Shareen; Nelson, Shannen; Dina, Blair; Sherwin, Catherine M T; Klein-Gitelman, Marisa S; Vinks, Alexander A; Brunner, Hermine I 2011. Pharmacokinetics and pharmacodynamics of mycophenolic acid and their relation to response to therapy of childhood-onset systemic lupus erythematosus. Seminars in arthritis and rheumatism, 40 4, 307-13Sagcal-Gironella, Anna Carmela P; Sherwin, Catherine M T; Tirona, Rommel G; Rieder, Michael J; Brunner, Hermine I; Vinks, Alexander A 2011. Pharmacokinetics of prednisolone at steady state in young patients with systemic lupus erythematosus on prednisone therapy: an open-label, single-dose study. Clinical therapeutics, 33 10, 1524-36Saldaña, Shannon N; Hooper, David K; Froehlich, Tanya E; Campbell, Kathleen M; Prows, Cynthia A; Sadhasivam, Senthilkumar; Nick, Todd G; Seid, Michael; Vinks, Alexander A; Glauser, Tracy A 2011. Characteristics of successful recruitment in prospective pediatric pharmacogenetic studies. Clinical therapeutics, 33 12, 2072-81Sherwin, Catherine M T; Ding, Lili; Kaplan, Jennifer; Spigarelli, Michael G; Vinks, Alexander A 2011. Optimal study design for pioglitazone in septic pediatric patients. Journal of pharmacokinetics and pharmacodynamics, 38 4, 433-47Sherwin, Catherine M T; Fukuda, Tsuyoshi; Brunner, Hermine I; Goebel, Jens; Vinks, Alexander A 2011. The evolution of population pharmacokinetic models to describe the enterohepatic recycling of mycophenolic acid in solid organ transplantation and autoimmune disease. Clinical pharmacokinetics, 50 1, 1-24Tett, Susan E; Saint-Marcoux, Franck; Staatz, Christine E; Brunet, Merce; Vinks, Alexander A; Miura, Masatomo; Marquet, Pierre; Kuypers, Dirk R; van Gelder, Teun; Cattaneo, Dario 2011. Mycophenolate, clinical pharmacokinetics, formulations, and methods for assessing drug exposure. Transplantation reviews (Orlando, Fla.), 25 2, 47-57Tönshoff, Burkhard; David-Neto, Elias; Ettenger, Robert; Filler, Guido; van Gelder, Teun; Goebel, Jens; Kuypers, Dirk R J; Tsai, Eileen; Vinks, Alexander A; Weber, Lutz T; Zimmerhackl, Lothar Bernd 2011. Pediatric aspects of therapeutic drug monitoring of mycophenolic acid in renal transplantation. Transplantation reviews (Orlando, Fla.), 25 2, 78-89Vinks, Alexander A 2011. Important role of population pharmacokinetic/pharmacodynamic modeling in pediatric therapeutics. The Journal of pediatrics, 159 3, 361-3Glauser, Tracy A; Cnaan, Avital; Shinnar, Shlomo; Hirtz, Deborah G; Dlugos, Dennis; Masur, David; Clark, Peggy O; Capparelli, Edmund V; Adamson, Peter C 2010. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. The New England journal of medicine, 362 9, 790-9Kuypers, Dirk R J; Le Meur, Yannick; Cantarovich, Marcelo; Tredger, Michael J; Tett, Susan E; Cattaneo, Dario; Tönshoff, Burkhard; Holt, David W; Chapman, Jeremy; Gelder, Teun van 2010. Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation. Clinical journal of the American Society of Nephrology : CJASN, 5 2, 341-58Mehta, Parinda A; Vinks, Alexander A; Filipovich, Alexandra; Bleesing, Jack; Jodele, Sonata; Jordan, Michael B; Marsh, Rebecca; Tarin, Richard; Edwards, Stephanie; Fearing, Deborah; Lawrence, Julia; Davies, Stella M 2010. Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 16 10, 1458-62Soldin, Offie P; Soldin, Steven J; Vinks, Alexander A; Younis, Islam; Landy, Helain J 2010. Longitudinal comparison of thyroxine pharmacokinetics between pregnant and nonpregnant women: a stable isotope study. Therapeutic drug monitoring, 32 6, 767-73Vargus-Adams, Jilda N; McMahon, Mary A; Michaud, Linda J; Bean, Judy; Vinks, Alexander A 2010. Pharmacokinetics of amantadine in children with impaired consciousness due to acquired brain injury: preliminary findings using a sparse-sampling technique. PM & R : the journal of injury, function, and rehabilitation, 2 1, 37-42Mouksassi, M S; Marier, J F; Cyran, J; Vinks, A A 2009. Clinical trial simulations in pediatric patients using realistic covariates: application to teduglutide, a glucagon-like peptide-2 analog in neonates and infants with short-bowel syndrome. Clinical pharmacology and therapeutics, 86 6, 667-71Pestian, John; Spencer, Malik; Matykiewicz, Pawel; Zhang, Kejian; Vinks, Alexander A; Glauser, Tracy 2009. Personalizing Drug Selection Using Advanced Clinical Decision Support. Biomedical informatics insights, 2 , 19-29Prausa, S E; Fukuda, T; Maseck, D; Curtsinger, K L; Liu, C; Zhang, K; Nick, T G; Sherbotie, J R; Ellis, E N; Goebel, J; Vinks, A A 2009. UGT genotype may contribute to adverse events following medication with mycophenolate mofetil in pediatric kidney transplant recipients. Clinical pharmacology and therapeutics, 85 5, 495-500Prows, Cynthia A; Nick, Todd G; Saldaña, Shannon N; Pathak, Sanjeev; Liu, Chunyan; Zhang, Kejian; Daniels, Zachary S; Vinks, Alexander A; Glauser, Tracy A 2009. Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients. Journal of child and adolescent psychopharmacology, 19 4, 385-94Thompson, Patrick A; Allen, Carl E; Horton, Terzah; Jones, Jeremy Y; Vinks, Alexander A; McClain, Kenneth L 2009. Severe neurologic side effects in patients being treated for hemophagocytic lymphohistiocytosis. Pediatric blood & cancer, 52 5, 621-5Aman, Michael G; Vinks, Alexander A; Remmerie, Bart; Mannaert, Erik; Ramadan, Yaser; Masty, Jessica; Lindsay, Ronald L; Malone, Krista 2007. Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disorders. Clinical therapeutics, 29 7, 1476-86Cabovska, B; Cox, S L; Vinks, A A 2007. Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 852 1-2, 497-504Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2007. Concentration-effect relationship of ceftazidime explains why the time above the MIC is 40 percent for a static effect in vivo. Antimicrobial agents and chemotherapy, 51 9, 3449-51Mouton, Johan W; Vinks, Alexander A 2007. Continuous infusion of beta-lactams. Current opinion in critical care, 13 5, 598-606Syed, Azeem; Vinks, Alexander A; Zakowski, Jack 2007. Trend in therapeutic monitoring of immunosuppressive drugs. MLO: medical laboratory observer, 39 7, 31-2Vinks, Alexander A; van Rossem, Ronald N; Mathôt, Ron A A; Heijerman, Harry G M; Mouton, Johan W 2007. Pharmacokinetics of aztreonam in healthy subjects and patients with cystic fibrosis and evaluation of dose-exposure relationships using monte carlo simulation. Antimicrobial agents and chemotherapy, 51 9, 3049-55Weimert, Nicole A; Derotte, Maurits; Alloway, Rita R; Woodle, E Steve; Vinks, Alexander A 2007. Monitoring of inosine monophosphate dehydrogenase activity as a biomarker for mycophenolic acid effect: potential clinical implications. Therapeutic drug monitoring, 29 2, 141-9Jiang, Zhengwen; Dragin, Nadine; Jorge-Nebert, Lucia F; Martin, Martha V; Guengerich, F Peter; Aklillu, Eleni; Ingelman-Sundberg, Magnus; Hammons, George J; Lyn-Cook, Beverly D; Kadlubar, Fred F; Saldana, Shannon N; Sorter, Michael; Vinks, Alexander A; Nassr, Nassr; von Richter, Oliver; Jin, Li; Nebert, Daniel W 2006. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenetics and genomics, 16 5, 359-67Mehta, Parinda; Vinks, Alexander; Filipovich, Alexandra; Vaughn, Gretchen; Fearing, Deborah; Sper, Christine; Davies, Stella 2006. High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 12 2, 235-40Carlsson, Kristin Cecilie; Hoem, Nils Ove; Glauser, Tracy; Vinks, Alexander A 2005. Development of a population pharmacokinetic model for carbamazepine based on sparse therapeutic monitoring data from pediatric patients with epilepsy. Clinical therapeutics, 27 5, 618-26de Wildt, Saskia N; de Hoog, Matthijs; Vinks, Alexander A; Joosten, Koen F M; van Dijk, Monique; van den Anker, John N 2005. Pharmacodynamics of midazolam in pediatric intensive care patients. Therapeutic drug monitoring, 27 1, 98-102Mouton, Johan W; Punt, Nieko; Vinks, Alexander A 2005. A retrospective analysis using Monte Carlo simulation to evaluate recommended ceftazidime dosing regimens in healthy volunteers, patients with cystic fibrosis, and patients in the intensive care unit. Clinical therapeutics, 27 6, 762-72Mouton, Johan W; Vinks, Alexander A 2005. Relationship between minimum inhibitory concentration and stationary concentration revisited: growth rates and minimum bactericidal concentrations. Clinical pharmacokinetics, 44 7, 767-8Mouton, Johan W; Vinks, Alexander A 2005. Pharmacokinetic/pharmacodynamic modelling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration. Clinical pharmacokinetics, 44 2, 201-10Touw, D J; Neef, C; Thomson, A H; Vinks, A A 2005. Cost-effectiveness of therapeutic drug monitoring: a systematic review. Therapeutic drug monitoring, 27 1, 10-7Bos, A M E; Boom, K; Vinks, A A; Boezen, H M; Wanders, J; Dombernovsky, P; Aamdal, S; de Vries, E G E; Uges, D R A 2004. Development of an optimal sampling strategy for clinical pharmacokinetic studies of the novel anthracycline disaccharide analogue MEN-10755. Cancer chemotherapy and pharmacology, 54 1, 64-70de Wildt, S N; de Hoog, M; Vinks, A A; van der Giesen, E; van den Anker, J N 2003. Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients. Critical care medicine, 31 7, 1952-8Sallee, Floyd R; Gilbert, Donald L; Vinks, Alexander A; Miceli, Jeffrey J; Robarge, Lisa; Wilner, Keith 2003. Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmission. Journal of the American Academy of Child and Adolescent Psychiatry, 42 8, 902-7Vinks, Alexander A; Den Hollander, Jan G; Overbeek, Shelley E; Jelliffe, Roger W; Mouton, Johan W 2003. Population pharmacokinetic analysis of nonlinear behavior of piperacillin during intermittent or continuous infusion in patients with cystic fibrosis. Antimicrobial agents and chemotherapy, 47 2, 541-7de Hoog, Matthijs; Schoemaker, Rik C; van den Anker, John N; Vinks, Alexander A 2002. NONMEM and NPEM2 population modeling: a comparison using tobramycin data in neonates. Therapeutic drug monitoring, 24 3, 359-65Le Brun, P P H; de Boer, A H; Mannes, G P M; de Fraîture, D M I; Brimicombe, R W; Touw, D J; Vinks, A A; Frijlink, H W; Heijerman, H G M 2002. Dry powder inhalation of antibiotics in cystic fibrosis therapy: part 2. Inhalation of a novel colistin dry powder formulation: a feasibility study in healthy volunteers and patients. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 54 1, 25-32Vinks, Alexander A 2002. The application of population pharmacokinetic modeling to individualized antibiotic therapy. International journal of antimicrobial agents, 19 4, 313-22Beringer, P M; Vinks, A A; Jelliffe, R W; Shapiro, B J 2000. Pharmacokinetics of tobramycin in adults with cystic fibrosis: implications for once-daily administration. Antimicrobial agents and chemotherapy, 44 4, 809-13Le Brun, P P; de Graaf, A I; Vinks, A A 2000. High-performance liquid chromatographic method for the determination of colistin in serum. Therapeutic drug monitoring, 22 5, 589-93Mouton, J W; Touzw, D J; Horrevorts, A M; Vinks, A A 2000. Comparative pharmacokinetics of the carbapenems: clinical implications. Clinical pharmacokinetics, 39 3, 185-201Natsch, S; Vinks, M H; Voogt, A K; Mees, E B; Meyboom, R H 2000. Anaphylactic reactions to proton-pump inhibitors. The Annals of pharmacotherapy, 34 4, 474-6Ververs, T F; van Dijk, A; Vinks, S A; Blankestijn, P J; Savelkoul, J F; Meulenbelt, J; Boereboom, F T 2000. Pharmacokinetics and dosing regimen of meropenem in critically ill patients receiving continuous venovenous hemofiltration. Critical care medicine, 28 10, 3412-6Le Brun, P P; Vinks, A A; Touw, D J; Hekelaar, N; Mannes, G P; Brimicombe, R W; Frijlink, E H; Heijerman, H G 1999. Can tobramycin inhalation be improved with a jet nebulizer? Therapeutic drug monitoring, 21 6, 618-24Morris, R G; Sallustio, B C; Vinks, A A; LeGatt, D F; Verjee, Z H; El Desoky, E 1999. Some international approaches to aminoglycoside monitoring in the extended dosing interval era. Therapeutic drug monitoring, 21 4, 379-88van Lent-Evers, N A; Mathôt, R A; Geus, W P; van Hout, B A; Vinks, A A 1999. Impact of goal-oriented and model-based clinical pharmacokinetic dosing of aminoglycosides on clinical outcome: a cost-effectiveness analysis. Therapeutic drug monitoring, 21 1, 63-73Beringer, P M; Vinks, A A; Jelliffe, R W 1998. Pharmacokinetics of once-daily amikacin dosing in patients with cystic fibrosis. The Journal of antimicrobial chemotherapy, 41 1, 142-4Touw, D J; Vinks, A A; Mouton, J W; Horrevorts, A M 1998. Pharmacokinetic optimisation of antibacterial treatment in patients with cystic fibrosis. Current practice and suggestions for future directions. Clinical pharmacokinetics, 35 6, 437-59Visser, L; Stricker, B; Hoogendoorn, M; Vinks, A 1998. Do not give paraffin to packers. Lancet (London, England), 352 9137, 1352Meyboom, R H; van Puijenbroek, E P; Vinks, M H; Lastdrager, C J 1997. Disturbance of withdrawal bleeding during concomitant use of itraconazole and oral contraceptives. The New Zealand medical journal, 110 1049, 300Mouton, J W; Vinks, A A; Punt, N C 1997. Pharmacokinetic-pharmacodynamic modeling of activity of ceftazidime during continuous and intermittent infusion. Antimicrobial agents and chemotherapy, 41 4, 733-8Touw, D J; Vinks, A A; Neef, C 1997. Pharmacokinetic modelling of intravenous tobramycin in adolescent and adult patients with cystic fibrosis using the nonparametric expectation maximization (NPEM) algorithm. Pharmacy world & science : PWS, 19 3, 142-51Vinks, A A; Brimicombe, R W; Heijerman, H G; Bakker, W 1997. Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics. The Journal of antimicrobial chemotherapy, 40 1, 125-33Mouton, J W; Vinks, A A 1996. Is continuous infusion of beta-lactam antibiotics worthwhile?--efficacy and pharmacokinetic considerations. The Journal of antimicrobial chemotherapy, 38 1, 5-15Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1996. Prospective evaluation of a dose prediction algorithm for intravenous tobramycin in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 2, 118-23Town, D J; Vinks, A A; Jacobs, F; Heijerman, H G; Bakker, W 1996. Creatinine clearance as predictor of tobramycin elimination in adult patients with cystic fibrosis. Therapeutic drug monitoring, 18 5, 562-9Vinks, A A; Mouton, J W; Touw, D J; Heijerman, H G; Danhof, M; Bakker, W 1996. Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategy. Antimicrobial agents and chemotherapy, 40 5, 1091-7Vinks, A A; Touw, D J; van Rossen, R C; Heijerman, H G; Bakker, W 1996. Stability of aztreonam in a portable pump reservoir used for home intravenous antibiotic treatment (HIVAT). Pharmacy world & science : PWS, 18 2, 74-7Touw, D J; Vinks, A A; Heijerman, H G; Hermans, J; Bakker, W 1994. Suggestions for the optimization of the initial tobramycin dose in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 16 2, 125-31Vinks, A A; Touw, D J; Heijerman, H G; Danhof, M; de Leede, G P; Bakker, W 1994. Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home. Therapeutic drug monitoring, 16 4, 341-8Bakker, W; Vinks, A A; Mouton, J W; de Jonge, P; Verzijl, J G; Heijerman, H G 1993. [Continuous intravenous home treatment of airway infections using ceftazidime administration via portable pump in patients with cystic fibrosis; a multicenter study]. Nederlands tijdschrift voor geneeskunde, 137 48, 2486-91Geus, W P; Vinks, A A; Smith, S J; Westra, P; Lamers, C B 1993. Comparison of two intravenous ranitidine regimens in a homogeneous population of intensive care unit patients. Alimentary pharmacology & therapeutics, 7 4, 451-7Mouton, J W; Vinks, A A 1993. [Antimicrobial treatment using beta-lactam antibiotics: continuous infusion appears to be sensible]. Nederlands tijdschrift voor geneeskunde, 137 48, 2476-80Touw, D J; Vinks, A A; Heijerman, H G; Bakker, W 1993. Validation of tobramycin monitoring in adolescent and adult patients with cystic fibrosis. Therapeutic drug monitoring, 15 1, 52-9Vinks, S A; Heijerman, H G; de Jonge, P; Bakker, W 1993. Photosensitivity due to ambulatory intravenous ceftazidime in cystic fibrosis patient. Lancet (London, England), 341 8854, 1221-2Geus, W P; Vinks, A A; Lamers, C B 1992. Pharmacokinetics of ranitidine in a homogeneous population of intensive care unit patients during intermittent and continuous administration. Scandinavian journal of gastroenterology. Supplement, 194 , 55-8Melissant, C F; Vinks, A A; Sleeboom, H P 1992. [Coma due to an overdose of valnoctamide]. Nederlands tijdschrift voor geneeskunde, 136 16, 793-4Hoogslag, P A; van Dijk, B; Vinks, A A 1989. [Respiratory depression following controlled-release morphine sulfate tablets]. Nederlands tijdschrift voor geneeskunde, 133 10, 516-7Keukens, F; van Voorst Vader, P C; Panders, A K; Vinks, S; Oosterhuis, J W; Kleijer, W J 1989. Xeroderma pigmentosum: squamous cell carcinoma of the tongue. Acta dermato-venereologica, 69 6, 530-1Inaba, T; Vinks, A; Otton, S V 1986. A simple borohydride/GC method for measuring sparteine metabolites in man. British journal of clinical pharmacology, 21 5, 473-80Van der Graaff, M; Vermeulen, N P; Vinks, M H; Breimer, D D 1986. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European journal of drug metabolism and pharmacokinetics, 11 2, 107-11Inaba, T; Vinks, A; Otton, S V; Kalow, W 1983. Comparative pharmacogenetics of sparteine and debrisoquine. Clinical pharmacology and therapeutics, 33 3, 394-9Slee, G L; Vinks, J A 1983. [Ileus following the use of loperamide (Imodium)]. Nederlands tijdschrift voor geneeskunde, 127 40, 1821-2Vinks, A; Inaba, T; Otton, S V; Kalow, W 1982. Sparteine metabolism in Canadian Caucasians. Clinical pharmacology and therapeutics, 31 1, 23-9Rogers, Christin C; Alloway, Rita R; Alexander, J Wesley; Cardi, Michael; Trofe, Jennifer; Vinks, Alexander A . Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study. Clinical transplantation, 22 3, 281-91Sadhasivam, Senthilkumar; Krekels, Elke H J; Chidambaran, Vidya; Esslinger, Hope R; Ngamprasertwong, Pornswan; Zhang, Kejian; Fukuda, Tsuyoshi; Vinks, Alexander A . Morphine clearance in children: does race or genetics matter? Journal of opioid management, 8 4, 217-26Williams, Michael T; Brown, Carrie A; Skelton, Matthew R; Vinks, Alexander A; Vorhees, Charles V . Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats. Neurotoxicology and teratology, 26 6, 849-56