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Photo of  Caroline E. Freiermuth, MD

Caroline E. Freiermuth, MD

Associate Professor of Clinical

Emergency Medicine | College of Medicine

Education/Credentials
  • Masters of Science: Duke University (Clinical Research)
  • Residency: University of Cincinnati (Emergency Medicine)
  • MD: University of Cincinnati
  • Bachelor of Science: Xavier University (Biology)
Board Certifications & Licenses

American Board of Emergency Medicine (Certification Date: 2011-06-08) - (Recertification Date: 2022-01-01)

Specialties

Emergency Medicine

Contact Information
Research Interests

Emergency Medicine

Clinical Interests

Emergency Medicine

Peer Reviewed Publications

D'Onofrio, Gail; Edelman, E Jennifer; Hawk, Kathryn F; Chawarski, Marek C; Pantalon, Michael V; Owens, Patricia H; Martel, Shara H; Rothman, Richard; Saheed, Mustapha; Schwartz, Robert P; Cowan, Ethan; Richardson, Lynne; Salsitz, Edwin; Lyons, Michael S; Freiermuth, Caroline; Wilder, Christine; Whiteside, Lauren; Tsui, Judith I; Klein, Jared W; Coupet, Edouard; O'Connor, Patrick G; Matthews, Abigail G; Murphy, Sean M; Huntley, Kristen; Fiellin, David A 2023. Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder. JAMA network open, 6 4, e235439

Freiermuth, Caroline E; Kisor, David F; Lambert, Joshua; Braun, Robert; Frey, Jennifer A; Bachmann, Daniel J; Bischof, Jason J; Lyons, Michael S; Pantalon, Michael V; Punches, Brittany E; Ancona, Rachel; Sprague, Jon E 2023. Genetic Variants Associated With Opioid Use Disorder. Clinical pharmacology and therapeutics, 113 5, 1089-1095

Bellolio, Fernanda; Broder, Joshua S; Oliveira J E Silva, Lucas; Freiermuth, Caroline E; Hooker, Edmond; Jang, Timothy B; Griffey, Richard T; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan; Prakken, Steven; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R 2022. Reply to "Letter to the Editor, re: GRACE-2: Low-Risk, Recurrent Abdominal Pain in the Emergency Department". Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 29 9, 1148-1150

Broder, Joshua S; Oliveira J E Silva, Lucas; Bellolio, Fernanda; Freiermuth, Caroline E; Griffey, Richard T; Hooker, Edmond; Jang, Timothy B; Meltzer, Andrew C; Mills, Angela M; Pepper, Joan D; Prakken, Steven D; Repplinger, Michael D; Upadhye, Suneel; Carpenter, Christopher R 2022. Guidelines for Reasonable and Appropriate Care in the Emergency Department 2 (GRACE-2): Low-risk, recurrent abdominal pain in the emergency department. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 29 5, 526-560

Faryar, Kiran A; Braun, Robert; Ancona, Rachel M; Freiermuth, Caroline; Lyons, Michael S 2022. Acceptance of HIV pre-exposure prophylaxis (PrEP) referral among a sample of PrEP-eligible emergency department patients. The American journal of emergency medicine, 60 , 152-155

Ojeda, Myriam Shaw; Chen, Aleda M H; Miracle, Tessa; Delaney, Elizabeth; Freiermuth, Caroline E; Sprague, Jon E 2022. HealthCare educational differences in pain management, adverse childhood experiences and their relationship to substance use disorder education. Substance abuse treatment, prevention, and policy, 17 1, 10

Punches, Brittany E; Brown, Jennifer L; Soliman, Summer; Johnson, Kimberly D; Freiermuth, Caroline E; Walker, Quinn; Omololu, Shammah O; Lyons, Michael S 2022. Patient Pain Experiences and the Emergency Department Encounter: A Qualitative Analysis. Pain management nursing : official journal of the American Society of Pain Management Nurses, 23 4, 391-396

Punches, Brittany E; Stolz, Uwe; Freiermuth, Caroline E; Ancona, Rachel M; McLean, Samuel A; House, Stacey L; Beaudoin, Francesca L; An, Xinming; Stevens, Jennifer S; Zeng, Donglin; Neylan, Thomas C; Clifford, Gari D; Jovanovic, Tanja; Linnstaedt, Sarah D; Germine, Laura T; Bollen, Kenneth A; Rauch, Scott L; Haran, John P; Storrow, Alan B; Lewandowski, Christopher; Musey, Paul I; Hendry, Phyllis L; Sheikh, Sophia; Jones, Christopher W; Kurz, Michael C; Gentile, Nina T; McGrath, Meghan E; Hudak, Lauren A; Pascual, Jose L; Seamon, Mark J; Harris, Erica; Chang, Anna M; Pearson, Claire; Peak, David A; Merchant, Roland C; Domeier, Robert M; Rathlev, Niels K; O'Neil, Brian J; Sanchez, Leon D; Bruce, Steven E; Pietrzak, Robert H; Joormann, Jutta; Barch, Deanna M; Pizzagalli, Diego A; Smoller, Jordan W; Luna, Beatriz; Harte, Steven E; Elliott, James M; Kessler, Ronald C; Ressler, Kerry J; Koenen, Karestan C; Lyons, Michael S 2022. Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study. PloS one, 17 9, e0273378

Westafer, Lauren M; Freiermuth, Caroline E; Lall, Michelle D; Muder, Sarah J; Ragone, Eleanor L; Jarman, Angela F 2022. Experiences of Transgender and Gender Expansive Physicians. JAMA network open, 5 6, e2219791

Whiteside, Lauren K; D'Onofrio, Gail; Fiellin, David A; Edelman, E Jennifer; Richardson, Lynne; O'Connor, Patrick; Rothman, Richard E; Cowan, Ethan; Lyons, Michael S; Fockele, Callan E; Saheed, Mustapha; Freiermuth, Caroline; Punches, Brittany E; Guo, Clara; Martel, Shara; Owens, Patricia H; Coupet, Edouard; Hawk, Kathryn F 2022. Models for Implementing Emergency Department-Initiated Buprenorphine With Referral for Ongoing Medication Treatment at Emergency Department Discharge in Diverse Academic Centers. Annals of emergency medicine, 80 5, 410-419

Eucker, Stephanie A; Manandhar, Pratik; Arulraja, Kami; Agnihotri, Deepti; Pollack, Charles V; Freiermuth, Caroline 2021. Higher daily pain severity after emergency department visits is associated with lower return-to-work rates. The American journal of emergency medicine, 45 , 48-53

Ibemere, Stephanie O; Dubbs, Sarah B; Barnhart, Huiman X; Brown, Jacqueline L; Freiermuth, Caroline E; Kavanagh, Patricia; Paice, Judith A; Strouse, John J; Wilkerson, R Gentry; Tanabe, Paula 2021. Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE). Contemporary clinical trials, 101 , 106252

Lane, Bennett H; Lyons, Michael S; Stolz, Uwe; Ancona, Rachel M; Ryan, Richard J; Freiermuth, Caroline E 2021. Naloxone provision to emergency department patients recognized as high-risk for opioid use disorder. The American journal of emergency medicine, 40 , 173-176

McCorkle, Maggie L; Kisor, David F; Freiermuth, Caroline E; Sprague, Jon E 2021. Systematic review of Pharmacogenomics Knowledgebase evidence for pharmacogenomic links to the dopamine reward pathway for heroin dependence. Pharmacogenomics, 22 13, 849-857

Punches, Brittany E; Ancona, Rachel M; Freiermuth, Caroline E; Brown, Jennifer L; Lyons, Michael S 2021. Incidence of opioid use disorder in the year after discharge from an emergency department encounter. Journal of the American College of Emergency Physicians open, 2 3, e12476

Punches, Brittany E; Berger, Kimberly M; Freiermuth, Caroline E; Soliman, Summer A; Walker, Quinn T; Lyons, Michael S 2021. Emergency Nurse Perceptions of Pain and Opioids in the Emergency Department. Pain management nursing : official journal of the American Society of Pain Management Nurses, 22 5, 586-591

Punches, Brittany E; Soliman, Summer; Freiermuth, Caroline E; Lane, Bennett H; Lyons, Michael S 2020. Emergency Nurse Perceptions of Naloxone Distribution in the Emergency Department. Journal of emergency nursing, 46 5, 675-681.e1

Freiermuth, Caroline E; Lavonas, Eric J; Anderson, Victoria E; Kleinschmidt, Kurt C; Sharma, Kapil; Rapp-Olsson, Malin; Gerardo, Charles 2019. Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation. The western journal of emergency medicine, 20 3, 497-505

Fulton, Jessica J; LeBlanc, Thomas W; Cutson, Toni M; Porter Starr, Kathryn N; Kamal, Arif; Ramos, Katherine; Freiermuth, Caroline E; McDuffie, Jennifer R; Kosinski, Andrzej; Adam, Soheir; Nagi, Avishek; Williams, John W 2019. Integrated outpatient palliative care for patients with advanced cancer: A systematic review and meta-analysis. Palliative medicine, 33 2, 123-134

Hughes, Jaime M; Freiermuth, Caroline E; Shepherd-Banigan, Megan; Ragsdale, Luna; Eucker, Stephanie A; Goldstein, Karen; Hastings, S Nicole; Rodriguez, Rachel L; Fulton, Jessica; Ramos, Katherine; Tabriz, Amir Alishahi; Gordon, Adelaide M; Gierisch, Jennifer M; Kosinski, Andrzej; Williams, John W 2019. Emergency Department Interventions for Older Adults: A Systematic Review. Journal of the American Geriatrics Society, 67 7, 1516-1525

Cline, David M; Silva, Susan; Freiermuth, Caroline E; Thornton, Victoria; Tanabe, Paula 2018. Emergency Department (ED), ED Observation, Day Hospital, and Hospital Admissions for Adults with Sickle Cell Disease. The western journal of emergency medicine, 19 2, 311-318

Gunn, Alexander H; Smothers, Zachary P W; Schramm-Sapyta, Nicole; Freiermuth, Caroline E; MacEachern, Mark; Muzyk, Andrew J 2018. The Emergency Department as an Opportunity for Naloxone Distribution. The western journal of emergency medicine, 19 6, 1036-1042

Kopec, Kathryn T; Freiermuth, Caroline; Maynard, Susan; Beuhler, Michael 2018. Dinitrophenol (DNP) Fatality Associated with a Falsely Elevated Salicylate Level: a Case Report with Verification of Laboratory Cross Reactivity. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 14 4, 323-326

Williams, Hants; Silva, R N Susan; Cline, David; Freiermuth, Caroline; Tanabe, Paula 2018. Social and Behavioral Factors in Sickle Cell Disease: Employment Predicts Decreased Health Care Utilization. Journal of health care for the poor and underserved, 29 2, 814-829

Tanabe, Paula; Freiermuth, Caroline E; Cline, David M; Silva, Susan 2017. A Prospective Emergency Department Quality Improvement Project to Improve the Treatment of Vaso-Occlusive Crisis in Sickle Cell Disease: Lessons Learned. Joint Commission journal on quality and patient safety, 43 3, 116-126

Freiermuth, Caroline E; Silva, Susan; Cline, David M; Tanabe, Paula 2016. Shift in Emergency Department Provider Attitudes Toward Patients With Sickle Cell Disease. Advanced emergency nursing journal, 38 3, 199-212

Dedert, Eric A; McDuffie, Jennifer R; Stein, Roy; McNiel, J Murray; Kosinski, Andrzej S; Freiermuth, Caroline E; Hemminger, Adam; Williams, John W 2015. Electronic Interventions for Alcohol Misuse and Alcohol Use Disorders: A Systematic Review. Annals of internal medicine, 163 3, 205-14

Freiermuth, Caroline E; Chandra, Abhinav; Peacock, W Frank 2015. Characteristics of patients that do not initially respond to intravenous antihypertensives in the emergency department: subanalysis of the CLUE trial. The western journal of emergency medicine, 16 2, 276-83

Freiermuth, Caroline E; Haywood, Carlton; Silva, Susan; Cline, David M; Kayle, Mariam; Sullivan, Dori; Thornton, Victoria; Tanabe, Paula 2014. Attitudes toward patients with sickle cell disease in a multicenter sample of emergency department providers. Advanced emergency nursing journal, 36 4, 335-47

Thornton, Victoria L; Holl, Jane L; Cline, David M; Freiermuth, Caroline E; Sullivan, Dori T; Tanabe, Paula 2014. Application of a proactive risk analysis to emergency department sickle cell care. The western journal of emergency medicine, 15 4, 446-58

Blomkalns, Andra L; O'Connell, Elise M; Eady, Caroline E; Lindsell, Christopher J; Gibler, W Brian 2006. Evaluation of dyslipidemia in the emergency department: impact of cholesterol testing on subsequent therapy. American heart journal, 152 6, 1182-6

Freiermuth C.E.;Silva S.;Cline D.M.;Tanabe P. 09-01-2016. Shift in Emergency Department Provider Attitudes Toward Patients with Sickle Cell Disease Advanced Emergency Nursing Journal, 38 3, 199-212

Williams H.;Silva S.;Cline D.;Freiermuth C.;Tanabe P. 05-01-2018. Social and behavioral factors in sickle cell disease: Employment predicts decreased health care util Journal of Health Care for the Poor and Underserved, 29 2, 814-829

Tanabe P.;Freiermuth C.E.;Cline D.M.;Silva S. 03-01-2017. A prospective emergency department quality improvement project to improve the treatment of vaso-occl Joint Commission Journal on Quality and Patient Safety, 43 3, 116-126

Fulton J.J.;LeBlanc T.W.;Cutson T.M.;Porter Starr K.N.;Kamal A.;Ramos K.;Freiermuth C.E.;McDuffie J.R.;Kosinski A.;Adam S.;Nagi A.;Williams J.W. 02-01-2019. Integrated outpatient palliative care for patients with advanced cancer: A systematic review and met Palliative Medicine, 33 2, 123-134

Freiermuth C.E.;Lavonas E.J.;Anderson V.E.;Kleinschmidt K.C.;Sharma K.;Rapp-Olsson M.;Gerardo C.;Bush S.;Mullins M.;Greene S.;Toschlog E.;Quackenbush E.;Rutherford Rose S.;Schwartz R.;Charlton N.;Lewis B.;Brandehoff N. 01-01-2019. Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation Western Journal of Emergency Medicine, 20 3, 497-505

Hughes J.M.;Freiermuth C.E.;Shepherd-Banigan M.;Ragsdale L.;Eucker S.A.;Goldstein K.;Hastings S.N.;Rodriguez R.L.;Fulton J.;Ramos K.;Tabriz A.A.;Gordon A.M.;Gierisch J.M.;Kosinski A.;Williams J.W. 01-01-2019. Emergency Department Interventions for Older Adults: A Systematic Review Journal of the American Geriatrics Society, ,

Thornton V.;Holl J.;Cline D.;Freiermuth C.;Sullivan D.;Tanabe P. 01-01-2014. Application of a proactive risk analysis to emergency department sickle cell care Western Journal of Emergency Medicine, 15 4, 446-458

Punches, Brittany E; Ali, Abeer Alhaj; Brown, Jennifer L; Freiermuth, Caroline E; Clark, Angela K; Lyons, Michael S . Opioid-Related Risk Screening Measures for the Emergency Care Setting. Advanced emergency nursing journal, 43 4, 331-343