William Miller, PhD

Miller, William E; O'Connor, Christine M 2024. CMV-encoded GPCRs in infection, disease, and pathogenesis. Advances in virus research, 118 , 1-75

Kalavacharla, Anusha; Koon, Chloe R; Freeman, MacKenzie R; Miller, William E 2023. Atypical patterns of human cytomegalovirus infection and spread in U373 glioblastoma cells. Virus research, 330 , 199112

Beucler, Matthew J; Miller, William E 2022. Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex. Journal of virology, , e0003122

Bridges, James P; Safina, Caterina; Pirard, Bernard; Brown, Kari; Filuta, Alyssa; Panchanathan, Ravichandran; Bouhelal, Rochdi; Reymann, Nicole; Patel, Sejal; Seuwen, Klaus; Miller, William E; Ludwig, Marie-Gabrielle 2022. Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism. eLife, 11 ,

O'Connor, Christine M; Miller, William E 2021. Methods for Studying the Function of Cytomegalovirus GPCRs. Methods in molecular biology (Clifton, N.J.), 2244 , 159-197

McDaniel, Cameron T; Panmanee, Warunya; Winsor, Geoffrey L; Gill, Erin; Bertelli, Claire; Schurr, Michael J; Dongare, Prateek; Paul, Andrew T; Ko, Seung-Hyun B; Lau, Gee W; Dasgupta, Nupur; Bogue, Amy L; Miller, William E; Mortensen, Joel E; Haslam, David B; Dexheimer, Phillip; Muruve, Daniel A; Aronow, Bruce J; Forbes, Malcolm D E; Danilczuk, Marek; Brinkman, Fiona S L; Hancock, Robert E W; Meyer, Thomas J; Hassett, Daniel J 2020. AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria. Proceedings of the National Academy of Sciences of the United States of America, 117 9, 4921-4930

Beucler, Matthew J; Miller, William E 2019. Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers. Journal of visualized experiments : JoVE, 149,

Jackson, Joseph W; Hancock, Trevor J; LaPrade, Ellen; Dogra, Pranay; Gann, Eric R; Masi, Thomas J; Panchanathan, Ravichandran; Miller, William E; Wilhelm, Steven W; Sparer, Tim E 2019. The Human Cytomegalovirus Chemokine vCXCL-1 Modulates Normal Dissemination Kinetics of Murine Cytomegalovirus In Vivo. mBio, 10 3,

Krishna, Benjamin A; Humby, Monica S; Miller, William E; O'Connor, Christine M 2019. Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. Proceedings of the National Academy of Sciences of the United States of America, 116 5, 1755-1764

Morrison, Kristen M; Beucler, Matthew J; Campbell, Emily O; White, Margaret A; Boody, Rachel E; Wilson, Keith C; Miller, William E 2019. Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium. Journal of virology, 93 3,

Krishna, Benjamin A; Miller, William E; O'Connor, Christine M 2018. US28: HCMV's Swiss Army Knife. Viruses, 10 8,

Brown, Kari; Filuta, Alyssa; Ludwig, Marie-Gabrielle; Seuwen, Klaus; Jaros, Julian; Vidal, Solange; Arora, Kavisha; Naren, Anjaparavanda P; Kandasamy, Kathirvel; Parthasarathi, Kaushik; Offermanns, Stefan; Mason, Robert J; Miller, William E; Whitsett, Jeffrey A; Bridges, James P 2017. Epithelial Gpr116 regulates pulmonary alveolar homeostasis via Gq/11 signaling. JCI insight, 2 11,

K. Brown, A. Filuta, M-G. Ludwig, K. Seuwen, J. Jaros, S. Vidal, K. Arora, A. Naren, K. Kandasamy, K. Parthasarathi, S. Offermanns, R. Mason, W.E. Miller, J.A. Whitsett, J. Bridges 2017. Epithelial Adgrf5 (Gpr116) Regulates Pulmonary Alveolar Homeostasis via Gq/11 Signaling JCI Insight, 2 11, 1-11

Dogra, Pranay; Miller-Kittrell, Mindy; Pitt, Elisabeth; Jackson, Joseph W; Masi, Tom; Copeland, Courtney; Wu, Shuen; Miller, William E; Sparer, Tim 2016. A little cooperation helps murine cytomegalovirus (MCMV) go a long way: MCMV co-infection rescues a chemokine salivary gland defect. The Journal of general virology, 97 11, 2957-2972

Low, Hann; Mukhamedova, Nigora; Cui, Huanhuan L; McSharry, Brian P; Avdic, Selmir; Hoang, Anh; Ditiatkovski, Michael; Liu, Yingying; Fu, Ying; Meikle, Peter J; Blomberg, Martin; Polyzos, Konstantinos A; Miller, William E; Religa, Piotr; Bukrinsky, Michael; Soderberg-Naucler, Cecilia; Slobedman, Barry; Sviridov, Dmitri 2016. Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells. Cell Reports, 16 1, 186-200

Wu, Shu-En; Miller, William E 2016. The HCMV US28 vGPCR induces potent Galphaq/PLeta signaling in monocytes leading to increased adhesion to endothelial cells Virology, 497 , 233-243

Wu, Shu-En; Miller, William E 2015. The human cytomegalovirus lytic cycle is induced by 1,25-dihydroxyvitamin D3 in peripheral blood monocytes and in the THP-1 monocytic cell line Virology, 483 , 83-95

Bittencourt, Fabiola M; Wu, Shu-En; Bridges, James P; Miller, William E 2014. The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland Journal of virology, 88 20, 11811-24

O'Connor, C. M. and Miller, W. E. 2014. Methods for Studying the Function of Cytomegalovirus GPCRs Methods in Molecular Biology: Human Cytomegaloviruses, 1119 , 133-64

Luttrell, Louis M; Miller, William E 2013. Arrestins as regulators of kinases and phosphatases Progress in molecular biology and translational science, 118 , 115-47

Millen, Scott H; Schneider, Olivia D; Miller, William E; Monaco, John J; Weiss, Alison A 2013. Pertussis toxin B-pentamer mediates intercellular transfer of membrane proteins and lipids. PloS one, 8 9, e72885

Simard, Elie; Kovacs, Jeffrey J; Miller, William E; Kim, Jihee; Grandbois, Michel; Lefkowitz, Robert J 2013. Beta-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. PloS one, 8 11, e80532

Miller, William E; Zagorski, William A; Brenneman, Joanna D; Avery, Diana; Miller, Jeanette L C; O 2012. US28 is a potent activator of phospholipase C during HCMV infection of clinically relevant target cells. PloS one, 7 11, e50524

Schneider, Olivia D; Millen, Scott H; Weiss, Alison A; Miller, William E 2012. Mechanistic insight into pertussis toxin and lectin signaling using T cells engineered to express a CD8alpha/CD3zeta chimeric receptor Biochemistry, 51 20, 4126-37

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist alpha-melanocortin and antagonists agouti signaling protein and beta-defensin 3 The Journal of investigative dermatology, 132 9, 2255-62

Schneider, Olivia D; Weiss, Alison A; Miller, William E 2009. Pertussis toxin signals through the TCR to initiate cross-desensitization of the chemokine receptor CXCR4. Journal of immunology (Baltimore, Md. : 1950), 182 9, 5730-9

Shenoy, Sudha K; Modi, Aalok S; Shukla, Arun K; Xiao, Kunhong; Berthouze, Magali; Ahn, Seungkirl; Wilkinson, Keith D; Miller, William E; Lefkowitz, Robert J 2009. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proceedings of the National Academy of Sciences of the United States of America, 106 16, 6650-5

Sherrill, Joseph D; Stropes, Melissa P; Schneider, Olivia D; Koch, Diana E; Bittencourt, Fabiola M; Miller, Jeanette L C; Miller, William E 2009. Activation of intracellular signaling pathways by the murine cytomegalovirus G protein-coupled receptor M33 occurs via PLC-beta/PKC-dependent and -independent mechanisms Journal of virology, 83 16, 8141-52

Stropes, Melissa P; Schneider, Olivia D; Zagorski, William A; Miller, Jeanette L C; Miller, William E 2009. The carboxy-terminal tail of human cytomegalovirus (HCMV) US28 regulates both chemokine-independent and chemokine-dependent signaling in HCMV-infected cells Journal of virology, 83 19, 10016-27

Sherrill, Joseph D; Miller, William E 2008. Desensitization of herpesvirus-encoded G protein-coupled receptors. Life sciences, 82 3-4, 125-34

Stropes, Melissa P M; Miller, William E 2008. Functional analysis of human cytomegalovirus pUS28 mutants in infected cells. The Journal of general virology, 89 Pt 1, 97-105

Schneider, Olivia D; Weiss, Alison A; Miller, William E 2007. Pertussis toxin utilizes proximal components of the T-cell receptor complex to initiate signal transduction events in T cells. Infection and immunity, 75 8, 4040-9

Sherrill, Joseph D; Miller, William E 2006. G protein-coupled receptor (GPCR) kinase 2 regulates agonist-independent Gq/11 signaling from the mouse cytomegalovirus GPCR M33. The Journal of biological chemistry, 281 52, 39796-805

Ardila-Osorio, Hector; Pioche-Durieu, Catherine; Puvion-Dutilleul, Francine; Clausse, Bernard; Wiels, Joëlle; Miller, William; Raab-Traub, Nancy; Busson, Pierre 2005. TRAF interactions with raft-like buoyant complexes, better than TRAF rates of degradation, differentiate signaling by CD40 and EBV latent membrane protein 1. International journal of cancer. Journal international du cancer, 113 2, 267-75

Wu, Jiao-Hui; Goswami, Robi; Kim, Luke K; Miller, William E; Peppel, Karsten; Freedman, Neil J 2005. The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition. The Journal of biological chemistry, 280 35, 31027-35

Mialet-Perez, Jeanne; Green, Stuart A; Miller, William E; Liggett, Stephen B 2004. A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation. The Journal of biological chemistry, 279 37, 38603-7

Stropes, Melissa P M; Miller, William E 2004. Signaling and regulation of G-protein coupled receptors encoded by cytomegaloviruses. Biochemistry and cell biology = Biochimie et biologie cellulaire, 82 6, 636-42

Witherow, D Scott; Garrison, Tiffany Runyan; Miller, William E; Lefkowitz, Robert J 2004. beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proceedings of the National Academy of Sciences of the United States of America, 101 23, 8603-7

Ahn, Seungkirl; Nelson, Christopher D; Garrison, Tiffany Runyan; Miller, William E; Lefkowitz, Robert J 2003. Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proceedings of the National Academy of Sciences of the United States of America, 100 4, 1740-4

Chen, Wei; ten Berge, Derk; Brown, Jeff; Ahn, Seungkirl; Hu, Liaoyuan A; Miller, William E; Caron, Marc G; Barak, Larry S; Nusse, Roel; Lefkowitz, Robert J 2003. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (New York, N.Y.), 301 5638, 1391-4

Miller, William E; Houtz, Daniel A; Nelson, Christopher D; Kolattukudy, P E; Lefkowitz, Robert J 2003. G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. The Journal of biological chemistry, 278 24, 21663-71

Wu, Jiao-Hui; Peppel, Karsten; Nelson, Christopher D; Lin, Fang-Tsyr; Kohout, Trudy A; Miller, William E; Exum, Sabrina T; Freedman, Neil J 2003. The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor. The Journal of biological chemistry, 278 45, 44238-45

Feldman, David S; Zamah, A Musa; Pierce, Kristen L; Miller, William E; Kelly, Francine; Rapacciuolo, Antonio; Rockman, Howard A; Koch, Walter J; Luttrell, Louis M 2002. Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. The Journal of biological chemistry, 277 32, 28631-40

Laporte, Stephane A; Miller, William E; Kim, Kyeong-Man; Caron, Marc G 2002. beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin. The Journal of biological chemistry, 277 11, 9247-54

Perry, Stephen J; Baillie, George S; Kohout, Trudy A; McPhee, Ian; Magiera, Maria M; Ang, Kok Long; Miller, William E; McLean, Alison J; Conti, Marco; Houslay, Miles D; Lefkowitz, Robert J 2002. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (New York, N.Y.), 298 5594, 834-6

Chen, W; Hu, L A; Semenov, M V; Yanagawa, S; Kikuchi, A; Lefkowitz, R J; Miller, W E 2001. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proceedings of the National Academy of Sciences of the United States of America, 98 26, 14889-94

Claing, A; Chen, W; Miller, W E; Vitale, N; Moss, J; Premont, R T; Lefkowitz, R J 2001. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. The Journal of biological chemistry, 276 45, 42509-13

Imamura, T; Huang, J; Dalle, S; Ugi, S; Usui, I; Luttrell, L M; Miller, W E; Lefkowitz, R J; Olefsky, J M 2001. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. The Journal of biological chemistry, 276 47, 43663-7

Luttrell, L M; Roudabush, F L; Choy, E W; Miller, W E; Field, M E; Pierce, K L; Lefkowitz, R J 2001. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proceedings of the National Academy of Sciences of the United States of America, 98 5, 2449-54

Miller, W E; Lefkowitz, R J 2001. Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Current opinion in cell biology, 13 2, 139-45

Miller, W E; Lefkowitz, R J 2001. Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener. Science's STKE : signal transduction knowledge environment, 2001 69, pe1

Miller, W E; McDonald, P H; Cai, S F; Field, M E; Davis, R J; Lefkowitz, R J 2001. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. The Journal of biological chemistry, 276 30, 27770-7

Hu, L A; Tang, Y; Miller, W E; Cong, M; Lau, A G; Lefkowitz, R J; Hall, R A 2000. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. The Journal of biological chemistry, 275 49, 38659-66

Maudsley, S; Pierce, K L; Zamah, A M; Miller, W E; Ahn, S; Daaka, Y; Lefkowitz, R J; Luttrell, L M 2000. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. The Journal of biological chemistry, 275 13, 9572-80

McDonald, P H; Chow, C W; Miller, W E; Laporte, S A; Field, M E; Lin, F T; Davis, R J; Lefkowitz, R J 2000. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (New York, N.Y.), 290 5496, 1574-7

Miller, W E; Maudsley, S; Ahn, S; Khan, K D; Luttrell, L M; Lefkowitz, R J 2000. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. The Journal of biological chemistry, 275 15, 11312-9

Seo, B; Choy, E W; Maudsley, S; Miller, W E; Wilson, B A; Luttrell, L M 2000. Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor. The Journal of biological chemistry, 275 3, 2239-45

Fries, K L; Miller, W E; Raab-Traub, N 1999. The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex. Virology, 264 1, 159-66

Lin, F T; Miller, W E; Luttrell, L M; Lefkowitz, R J 1999. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. The Journal of biological chemistry, 274 23, 15971-4

Luttrell, L M; Ferguson, S S; Daaka, Y; Miller, W E; Maudsley, S; Della Rocca, G J; Lin, F; Kawakatsu, H; Owada, K; Luttrell, D K; Caron, M G; Lefkowitz, R J 1999. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (New York, N.Y.), 283 5402, 655-61

Miller, W E; Raab-Traub, N 1999. The EGFR as a target for viral oncoproteins. Trends in microbiology, 7 11, 453-8

Takeshita, H; Yoshizaki, T; Miller, W E; Sato, H; Furukawa, M; Pagano, J S; Raab-Traub, N 1999. Matrix metalloproteinase 9 expression is induced by Epstein-Barr virus latent membrane protein 1 C-terminal activation regions 1 and 2. Journal of virology, 73 7, 5548-55

Tang, Y; Hu, L A; Miller, W E; Ringstad, N; Hall, R A; Pitcher, J A; DeCamilli, P; Lefkowitz, R J 1999. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America, 96 22, 12559-64

Hatzivassiliou, E; Miller, W E; Raab-Traub, N; Kieff, E; Mosialos, G 1998. A fusion of the EBV latent membrane protein-1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-kappa B, and stress-activated protein kinase. Journal of immunology (Baltimore, Md. : 1950), 160 3, 1116-21

Miller, W E; Cheshire, J L; Baldwin, A S; Raab-Traub, N 1998. The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa B and induction of the EGFR in epithelial cells. Oncogene, 16 14, 1869-77

Miller, W E; Cheshire, J L; Raab-Traub, N 1998. Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression. Molecular and cellular biology, 18 5, 2835-44

Patel, A; Hanson, J; McLean, T I; Olgiate, J; Hilton, M; Miller, W E; Bachenheimer, S L 1998. Herpes simplex type 1 induction of persistent NF-kappa B nuclear translocation increases the efficiency of virus replication. Virology, 247 2, 212-22

Miller, W E; Mosialos, G; Kieff, E; Raab-Traub, N 1997. Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation. Journal of virology, 71 1, 586-94

Fries, K L; Miller, W E; Raab-Traub, N 1996. Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. Journal of virology, 70 12, 8653-9

Miller, W E; Earp, H S; Raab-Traub, N 1995. The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor. Journal of virology, 69 7, 4390-8

Miller, W E; Edwards, R H; Walling, D M; Raab-Traub, N 1994. Sequence variation in the Epstein-Barr virus latent membrane protein 1. The Journal of general virology, 75 ( Pt 10) , 2729-40