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Samuel Slone

samuel_slone

Year in Program: 5th

Hometown: Cincinnati, Ohio

Mentor: Dr. Tranter

Email: slonesf@mail.uc.edu

American Heart Association Predoctoral Fellowship

My long-term research interest involves a comprehensive understanding and elucidation of key pathways, transcription/translation modifications, and the complex protein interactions involving cardiomyocytes in cardiac pathology, with the ultimate goal of contributing to the development of a therapeutic treatment for cardiovascular disease. My thesis focuses specifically on increasing our understanding of the underlying molecular mechanisms of the RNA binding protein Human Antigen R (HuR) in modulating the innate immune response following cardiac ischemia/reperfusion (I/R) injury, and on identifying the therapeutic potential of HuR inhibition to preserve cardiomyocyte survival post-reperfusion. While cardiac expression of HuR has been shown to be increased within three days post-I/R and play a role in post-Infarct remodeling, the role of HuR in cardiomyocyte survival following I/R injury is poorly understood and therefore needs to be addressed. Recent findings have suggested that HuR modulates/stabilizes inflammatory factors such as IL-6, TNF-alpha, IL-B and others during I/R both in vivo and in vitro. Therefore, I am interested in HuR's role in modulating pro-inflammatory cytokines and chemokines post-I/R and the effects of inhibiting HuR via a cardiomyocyte-specific knockout or a novel small molecule inhibitor cell on cardiomyocyte survival and thus cardiac remodeling and function. In addition, I would like to pursue HuR's involvement in mediating macrophage/neutrophil infiltration to the myocardium post-I/R.

Publications, Complete List at PubMed

Contact Us

Systems Biology and Physiology
Graduate Program

Medical Sciences Building Room 4259A
231 Albert Sabin Way
PO Box 670576
Cincinnati, OH 45267-0576

Mail Location: 0576
Phone: 513-558-3102
FAX: 513-558-5738
Email: jeannie.cummins@uc.edu