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Photo of  Rajat Madan, MD,PhD

Rajat Madan, MD,PhD

Associate Professor of Clinical

Internal Medicine | College of Medicine

  • Fellowship: University of Virginia (Infectious Diseases)
  • Residency: The Christ Hospital (Internal Medicine)
  • Doctoral Degree: University of Cincinnati (Molecular and Developmental Biology and Molecular Immunology)
  • Bachelor of Medicine, Bachelor or Surgery (M.B.B.S): JLN Medical College
Board Certifications & Licenses

American Board of Internal Medicine (Infectious Disease) (Certification Date: 2014-10-28)
American Board of Internal Medicine (Certification Date: 2011-08-12) - (Recertification Date: 2023-01-01)


Infectious Diseases
Internal Medicine

Contact Information
Research Interests

The overall goal of our studies is to define novel, host targets for the treatment of infectious diseases. Ever since the discovery of Penicillin, infectious disease therapies have focused on targeting the offending pathogen by using anti-microbial approaches. However, microbes have evolved for billions of years and have mechanisms that allow them to escape such strategies as evidenced by high degree of antibiotic resistance. Further, it is well-known that host factors (e.g., genetic make-up and intensity...

Clinical Interests

Infectious Disease

Peer Reviewed Publications

Alam, Md Zahidul; Madan, Rajat 2024. Clostridioides difficile Toxins: Host Cell Interactions and Their Role in Disease Pathogenesis. Toxins, 16 6,

Markantonis JE, Fallon JT, Madan R, Zahidul MA. 2024. Clostridioides difficile infection: diagnosis and treatment challenges. Pathogens, 13 2, 118

Mathew AM, Huber A, Sous RD, Weghorn KN, Powers-Fletcher M, Jose S, Madan R 2024. Effect of leptin receptor Q223R polymorphism on Clostridioides difficile infection-induced macrophage migration inhibitory factor production Journal of Infectious Diseases, ,

Mathew, Ann M; Huber, Alexander; Sous, Rowis D; Weghorn, Kristin N; Powers-Fletcher, Margaret V; Jose, Shinsmon; Madan, Rajat 2024. Effect of Leptin Receptor Q223R Polymorphism on Clostridioides difficile Infection-Induced Macrophage Migration Inhibitory Factor Production. The Journal of infectious diseases, ,

Huber, A; Jose, S; Kassam, A; Weghorn, K N; Powers-Fletcher, Maggie; Sharma, D; Mukherjee, A; Mathew, A; Kulkarni, N; Chandramouli, S; Alder, M N; Madan, R 2023. Olfactomedin-4 + neutrophils exacerbate intestinal epithelial damage and worsen host survival after Clostridioides difficile infection. bioRxiv : the preprint server for biology, ,

Alarcon, Pablo C; Damen, Michelle S M A; Madan, Rajat; Deepe, George S; Spearman, Paul; Way, Sing Sing; Divanovic, Senad 2021. Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution. Mucosal immunology, ,

Horrigan, Olivia; Jose, Shinsmon; Mukherjee, Anindita; Sharma, Divya; Huber, Alexander; Madan, Rajat 2021. Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1? Dependent Manner. Frontiers in cellular and infection microbiology, 11 , 619192

Jose, Shinsmon; Mukherjee, Anindita; Horrigan, Olivia; Setchell, Kenneth D R; Zhang, Wujuan; Moreno-Fernandez, Maria E; Andersen, Heidi; Sharma, Divya; Haslam, David B; Divanovic, Senad; Madan, Rajat 2021. Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. Mucosal immunology, 14 2, 500-510

Jose, Shinsmon; Mukherjee, Anindita; Abhyankar, Mayuresh M; Leng, Lin; Bucala, Richard; Sharma, Divya; Madan, Rajat 2018. Neutralization of macrophage migration inhibitory factor improves host survival after Clostridium difficile infection. Anaerobe, ,

Vargas, Edwin; Apewokin, Senu; Madan, Rajat 2017. Role of the leukocyte response in normal and immunocompromised host after Clostridium difficile infection. Anaerobe, 45 , 101-105

Jose, Shinsmon; Madan, Rajat 2016. Neutrophil-mediated inflammation in the pathogenesis of Clostridium difficile infections. Anaerobe, ,

Madan, Rajat; Petri, William A 2015. Role of obesity and adipose tissue-derived cytokine leptin during Clostridium difficile infection. Anaerobe, 34 , 182-6

Madan, Rajat; Guo, Xiaoti; Naylor, Caitlin; Buonomo, Erica L; Mackay, Donald; Noor, Zannatun; Concannon, Patrick; Scully, Kenneth W; Pramoonjago, Patcharin; Kolling, Glynis L; Warren, Cirle A; Duggal, Priya; Petri, William A 2014. Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infection and immunity, 82 1, 341-9

Naylor, Caitlin; Burgess, Stacey; Madan, Rajat; Buonomo, Erica; Razzaq, Khadija; Ralston, Katherine; Petri, William A 2014. Leptin receptor mutation results in defective neutrophil recruitment to the colon during Entamoeba histolytica infection. mBio, 5 6,

Buonomo, Erica L; Madan, Rajat; Pramoonjago, Patcharin; Li, Li; Okusa, Mark D; Petri, William A 2013. Role of interleukin 23 signaling in Clostridium difficile colitis. The Journal of infectious diseases, 208 6, 917-20

Jarrell, Andrew; Kawsky, Jaclyn; Johnson, Tara; Voss, Sasha; Madan, Rajat; Weitkamp, Tina; Wigle, Patricia 2013. An interdisciplinary approach to determine schistosomiasis prevalence and administer praziquantel to school-age children in Tanzania. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 70 21, 1880-2

Madan, Rajat; Jr, William A Petri 2012. Immune responses to Clostridium difficile infection. Trends in molecular medicine, 18 11, 658-66

Denning, Timothy L; Norris, Brian A; Medina-Contreras, Oscar; Manicassamy, Santhakumar; Geem, Duke; Madan, Rajat; Karp, Christopher L; Pulendran, Bali 2011. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. Journal of immunology (Baltimore, Md. : 1950), 187 2, 733-47

Madan, Rajat; Demircik, Filiz; Surianarayanan, Sangeetha; Allen, Jessica L; Divanovic, Senad; Trompette, Aurelien; Yogev, Nir; Gu, Yuanyuan; Khodoun, Marat; Hildeman, David; Boespflug, Nicholas; Fogolin, Mariela B; Gröbe, Lothar; Greweling, Marina; Finkelman, Fred D; Cardin, Rhonda; Mohrs, Markus; Müller, Werner; Waisman, Ari; Roers, Axel; Karp, Christopher L 2009. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. Journal of immunology (Baltimore, Md. : 1950), 183 4, 2312-20

Murai, Masako; Turovskaya, Olga; Kim, Gisen; Madan, Rajat; Karp, Christopher L; Cheroutre, Hilde; Kronenberg, Mitchell 2009. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature immunology, 10 11, 1178-84

Perona-Wright, Georgia; Mohrs, Katja; Szaba, Frank M; Kummer, Lawrence W; Madan, Rajat; Karp, Christopher L; Johnson, Lawrence L; Smiley, Stephen T; Mohrs, Markus 2009. Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell host & microbe, 6 6, 503-12

Pot, Caroline; Jin, Hulin; Awasthi, Amit; Liu, Sue Min; Lai, Chen-Yen; Madan, Rajat; Sharpe, Arlene H; Karp, Christopher L; Miaw, Shi-Chuen; Ho, I-Cheng; Kuchroo, Vijay K 2009. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. Journal of immunology (Baltimore, Md. : 1950), 183 2, 797-801

Sun, Jie; Madan, Rajat; Karp, Christopher L; Braciale, Thomas J 2009. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nature medicine, 15 3, 277-84

Trompette, Aurelien; Divanovic, Senad; Visintin, Alberto; Blanchard, Carine; Hegde, Rashmi S; Madan, Rajat; Thorne, Peter S; Wills-Karp, Marsha; Gioannini, Theresa L; Weiss, Jerry P; Karp, Christopher L 2009. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature, 457 7229, 585-8

Dragin, Nadine; Shi, Zhanquan; Madan, Rajat; Karp, Christopher L; Sartor, Maureen A; Chen, Chi; Gonzalez, Frank J; Nebert, Daniel W 2008. Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. Molecular pharmacology, 73 6, 1844-56

Machado, Fabiana S; Esper, Lísia; Dias, Alexandra; Madan, Rajat; Gu, YuanYuan; Hildeman, David; Serhan, Charles N; Karp, Christopher L; Aliberti, Júlio 2008. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. The Journal of experimental medicine, 205 5, 1077-86

Divanovic, Senad; Trompette, Aurelien; Petiniot, Lisa K; Allen, Jessica L; Flick, Leah M; Belkaid, Yasmine; Madan, Rajat; Haky, Jennifer J; Karp, Christopher L 2007. Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. Journal of leukocyte biology, 82 2, 265-71

Tripathi, Pulak; Madan, Rajat; Chougnet, Claire; Divanovic, Senad; Ma, Xiaojing; Wahl, Larry M; Gajewski, Thomas; Karp, Christopher L; Hildeman, David A 2006. An adenoviral vector for probing promoter activity in primary immune cells. Journal of immunological methods, 311 1-2, 19-30

Divanovic, Senad; Trompette, Aurelien; Atabani, Sowsan F; Madan, Rajat; Golenbock, Douglas T; Visintin, Alberto; Finberg, Robert W; Tarakhovsky, Alexander; Vogel, Stefanie N; Belkaid, Yasmine; Kurt-Jones, Evelyn A; Karp, Christopher L 2005. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nature immunology, 6 6, 571-8

Divanovic, Senad; Trompette, Aurelien; Atabani, Sowsan F; Madan, Rajat; Golenbock, Douglas T; Visintin, Alberto; Finberg, Robert W; Tarakhovsky, Alexander; Vogel, Stefanie N; Belkaid, Yasmine; Kurt-Jones, Evelyn A; Karp, Christopher L 2005. Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. Journal of endotoxin research, 11 6, 363-8