Karthickeyan Chella Krishnan, PhD

Assali, Essam A; Taha, Mahmoud; Salhab, Ahmad; Amer, Johnny; Krishnan, Karthickeyan Chella; Kostic, Marko; Veliova, Michaela; Brownstein, Alexandra J; Shirihai, Orian S; Safadi, Rifaat; Sekler, Israel 2026. Mitochondrial NCLX Couples Glucagon- and PDE2A-Dependent Signals to Regulate Hepatic Lipid Metabolism. Molecular metabolism, , 102433

Igel, Emily; Jaeschke, Anja; Haller, April; Asman, Melissa; Mattam, Ushodaya; Alagarsamy, Jeyashree; Chella Krishnan, Karthickeyan; Hui, David Y 2026. Cell type-specific control of cardiometabolic disease by the dileucine motif of the LDL receptor-related protein LRP1. The Journal of biological chemistry, 302 5, 111421

Porteymour, Shirin; Sajib, Saikat Das; von Hofsten, Susannah; Doncheva, Atanaska I; Bjørnvall, Christina D; Hegge, Beate; Gautier, Mélina; Grujic, Mirjana; Kolan, Pratibha; Krishnan, Karthickeyan Chella; Matthews, Jason; Dalen, Knut T; Pejler, Gunnar; Kolset, Svein O; Knutsen, Erik; Norheim, Frode A 2026. Serglycin modulates inflammation and metabolism in macrophages. iScience, 29 4, 115235

Mattam, Ushodaya; Talari, Noble Kumar; Rao Sathyanarayana, Ashish; Mia, Sobuj; Frazier, James; Alagarsamy, Jeyashree; Slone, Sam; Drosatos, Konstantinos; Chella Krishnan, Karthickeyan 2025. Isolated mouse adult cardiomyocytes display minimal mitochondrial ATP demand and maximal reliance on glycolysis. Journal of molecular and cellular cardiology, 204 , 1-4

Talari, Noble Kumar; Mattam, Ushodaya; Rahman, Afra P; Hemmelgarn, Brook K; Wyder, Michael A; Sylvestre, Pamela B; Greis, Kenneth D; Chella Krishnan, Karthickeyan 2025. Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression. Communications biology, 8 1, 258

He, Xingyu; Good, Angela; Kalou, Wael; Ahmad, Waqas; Dutta, Suchandrima; Chen, Sophie; Lin, Charles Noah; Chella Krishnan, Karthickeyan; Fan, Yanbo; Huang, Wei; Liang, Jialiang; Wang, Yigang 2024. Current Advances and Future Directions of Pluripotent Stem Cells-Derived Engineered Heart Tissue for Treatment of Cardiovascular Diseases. Cells, 13 24,

Mattam, Ushodaya; Talari, Noble Kumar; Sathyanarayana, Ashish Rao; Mia, Sobuj; Frazier, James; Slone, Sam; Drosatos, Konstantinos; Chella Krishnan, Karthickeyan 2024. Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis. bioRxiv : the preprint server for biology, ,

Talari, Noble Kumar; Mattam, Ushodaya; Kaminska, Dorota; Sotomayor-Rodriguez, Irene; Rahman, Afra P; Péterfy, Miklós; Pajukanta, Päivi; Pihlajamäki, Jussi; Chella Krishnan, Karthickeyan 2024. Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis. iScience, 27 5, 109709

Chella Krishnan, Karthickeyan 2023. When diet meets genetics. eLife, 12 ,

Chella Krishnan, Karthickeyan; El Hachem, Elie-Julien; Keller, Mark P; Patel, Sanjeet G; Carroll, Luke; Vegas, Alexis Diaz; Gerdes Gyuricza, Isabela; Light, Christine; Cao, Yang; Pan, Calvin; Kaczor-Urbanowicz, Karolina Elżbieta; Shravah, Varun; Anum, Diana; Pellegrini, Matteo; Lee, Chi Fung; Seldin, Marcus M; Rosenthal, Nadia A; Churchill, Gary A; Attie, Alan D; Parker, Benjamin; James, David E; Lusis, Aldons J 2023. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. eLife, 12 ,

Patel, Sanil; Sparman, Njeri Z R; Arneson, Douglas; Alvarsson, Alexandra; Santos, Luís C; Duesman, Samuel J; Centonze, Alessia; Hathaway, Ephraim; Ahn, In Sook; Diamante, Graciel; Cely, Ingrid; Cho, Chung Hwan; Talari, Noble Kumar; Rajbhandari, Abha K; Goedeke, Leigh; Wang, Peng; Butte, Atul J; Blanpain, Cédric; Chella Krishnan, Karthickeyan; Lusis, Aldons J; Stanley, Sarah A; Yang, Xia; Rajbhandari, Prashant 2023. Mammary duct luminal epithelium controls adipocyte thermogenic programme. Nature, 620 7972, 192-199

Cao, Yang; Vergnes, Laurent; Wang, Yu-Chen; Pan, Calvin; Chella Krishnan, Karthickeyan; Moore, Timothy M; Rosa-Garrido, Manuel; Kimball, Todd H; Zhou, Zhiqiang; Charugundla, Sarada; Rau, Christoph D; Seldin, Marcus M; Wang, Jessica; Wang, Yibin; Vondriska, Thomas M; Reue, Karen; Lusis, Aldons J 2022. Sex differences in heart mitochondria regulate diastolic dysfunction. Nature communications, 13 1, 3850

Acín-Perez, Rebeca; Petcherski, Anton; Veliova, Michaela; Benador, Ilan Y; Assali, Essam A; Colleluori, Georgia; Cinti, Saverio; Brownstein, Alexandra J; Baghdasarian, Siyouneh; Livhits, Masha J; Yeh, Michael W; Krishnan, Karthickeyan Chella; Vergnes, Laurent; Winn, Nathan C; Padilla, Jaume; Liesa, Marc; Sacks, Harold S; Shirihai, Orian S 2021. Recruitment and remodeling of peridroplet mitochondria in human adipose tissue. Redox biology, 46 , 102087

Chella Krishnan, Karthickeyan; Floyd, Raquel R; Sabir, Simon; Jayasekera, Dulshan W; Leon-Mimila, Paola V; Jones, Anthony E; Cortez, Angel A; Shravah, Varun; Péterfy, Miklós; Stiles, Linsey; Canizales-Quinteros, Samuel; Divakaruni, Ajit S; Huertas-Vazquez, Adriana; Lusis, Aldons J 2021. Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cellular and molecular gastroenterology and hepatology, 11 2, 389-406

Chella Krishnan, Karthickeyan; Vergnes, Laurent; Acín-Pérez, Rebeca; Stiles, Linsey; Shum, Michael; Ma, Lijiang; Mouisel, Etienne; Pan, Calvin; Moore, Timothy M; Péterfy, Miklós; Romanoski, Casey E; Reue, Karen; Björkegren, Johan L M; Laakso, Markku; Liesa, Marc; Lusis, Aldons J 2021. Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2. Nature metabolism, 3 11, 1552-1568

Ferrara, Patrick J; Rong, Xin; Maschek, J Alan; Verkerke, Anthony Rp; Siripoksup, Piyarat; Song, Haowei; Green, Thomas D; Krishnan, Karthickeyan C; Johnson, Jordan M; Turk, John; Houmard, Joseph A; Lusis, Aldons J; Drummond, Micah J; McClung, Joseph M; Cox, James E; Shaikh, Saame Raza; Tontonoz, Peter; Holland, William L; Funai, Katsuhiko 2021. Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle. The Journal of clinical investigation, 131 8,

Norheim, Frode; Chella Krishnan, Karthickeyan; Bjellaas, Thomas; Vergnes, Laurent; Pan, Calvin; Parks, Brian W; Meng, Yonghong; Lang, Jennifer; Ward, James A; Reue, Karen; Mehrabian, Margarete; Gundersen, Thomas E; Péterfy, Miklós; Dalen, Knut T; Drevon, Christian A; Hui, Simon T; Lusis, Aldons J; Seldin, Marcus M 2021. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Molecular systems biology, 17 1, e9684

Shum, Michael; Shintre, Chitra A; Althoff, Thorsten; Gutierrez, Vincent; Segawa, Mayuko; Saxberg, Alexandra D; Martinez, Melissa; Adamson, Roslin; Young, Margaret R; Faust, Belinda; Gharakhanian, Raffi; Su, Shi; Chella Krishnan, Karthickeyan; Mahdaviani, Kiana; Veliova, Michaela; Wolf, Dane M; Ngo, Jennifer; Nocito, Laura; Stiles, Linsey; Abramson, Jeff; Lusis, Aldons J; Hevener, Andrea L; Zoghbi, Maria E; Carpenter, Elisabeth P; Liesa, Marc 2021. ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity. Science translational medicine, 13 594,

Acín-Pérez, Rebeca; Iborra, Salvador; Martí-Mateos, Yolanda; Cook, Emma C L; Conde-Garrosa, Ruth; Petcherski, Anton; Muñoz, Mª Del Mar; Martínez de Mena, Raquel; Krishnan, Karthickeyan Chella; Jiménez, Concepción; Bolaños, Juan Pedro; Laakso, Markku; Lusis, Aldon J; Shirihai, Orian S; Sancho, David; Enríquez, José Antonio 2020. Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Nature metabolism, 2 9, 974-988

Nookala, Suba; Krishnan, Karthickeyan Chella; Mukundan, Santhosh; Kotb, Malak 2020. Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections. Advances in experimental medicine and biology, 1294 , 151-166

Zhang, Guanglin; Byun, Hyae Ran; Ying, Zhe; Blencowe, Montgomery; Zhao, Yuqi; Hong, Jason; Shu, Le; Chella Krishnan, Karthick; Gomez-Pinilla, Fernando; Yang, Xia 2020. Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice. Biochimica et biophysica acta. Molecular basis of disease, 1866 1, 165569

Chella Krishnan, Karthickeyan; Sabir, Simon; Shum, Michaël; Meng, Yonghong; Acín-Pérez, Rebeca; Lang, Jennifer M; Floyd, Raquel R; Vergnes, Laurent; Seldin, Marcus M; Fuqua, Brie K; Jayasekera, Dulshan W; Nand, Sereena K; Anum, Diana C; Pan, Calvin; Stiles, Linsey; Péterfy, Miklós; Reue, Karen; Liesa, Marc; Lusis, Aldons J 2019. Sex-specific metabolic functions of adipose Lipocalin-2. Molecular metabolism, 30 , 30-47

Norheim, Frode; Hasin-Brumshtein, Yehudit; Vergnes, Laurent; Chella Krishnan, Karthickeyan; Pan, Calvin; Seldin, Marcus M; Hui, Simon T; Mehrabian, Margarete; Zhou, Zhiqiang; Gupta, Sonul; Parks, Brian W; Walch, Axel; Reue, Karen; Hofmann, Susanna M; Arnold, Arthur P; Lusis, Aldons J 2019. Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell metabolism, 29 4, 932-949.e4

Chella Krishnan, Karthickeyan; Kurt, Zeyneb; Barrere-Cain, Rio; Sabir, Simon; Das, Aditi; Floyd, Raquel; Vergnes, Laurent; Zhao, Yuqi; Che, Nam; Charugundla, Sarada; Qi, Hannah; Zhou, Zhiqiang; Meng, Yonghong; Pan, Calvin; Seldin, Marcus M; Norheim, Frode; Hui, Simon; Reue, Karen; Lusis, Aldons J; Yang, Xia 2018. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell systems, 6 1, 103-115.e7

Chella Krishnan, Karthickeyan; Mehrabian, Margarete; Lusis, Aldons J 2018. Sex differences in metabolism and cardiometabolic disorders. Current opinion in lipidology, 29 5, 404-410

Hui, Simon T; Kurt, Zeyneb; Tuominen, Iina; Norheim, Frode; C Davis, Richard; Pan, Calvin; Dirks, Darwin L; Magyar, Clara E; French, Samuel W; Chella Krishnan, Karthickeyan; Sabir, Simon; Campos-Pérez, Francisco; Méndez-Sánchez, Nahum; Macías-Kauffer, Luis; León-Mimila, Paola; Canizales-Quinteros, Samuel; Yang, Xia; Beaven, Simon W; Huertas-Vazquez, Adriana; Lusis, Aldons J 2018. The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice. Hepatology (Baltimore, Md.), 68 6, 2182-2196

Norheim, Frode; Bjellaas, Thomas; Hui, Simon T; Chella Krishnan, Karthickeyan; Lee, Jakleen; Gupta, Sonul; Pan, Calvin; Hasin-Brumshtein, Yehudit; Parks, Brian W; Li, Daniel Y; Bui, Hai H; Mosier, Marian; Wu, Yuping; Huertas-Vazquez, Adriana; Hazen, Stanley L; Gundersen, Thomas E; Mehrabian, Margarete; Tang, W H Wilson; Hevener, Andrea L; Drevon, Christian A; Lusis, Aldons J 2018. Genetic, dietary, and sex-specific regulation of hepatic ceramides and the relationship between hepatic ceramides and IR. Journal of lipid research, 59 7, 1164-1174

Seldin, Marcus M; Koplev, Simon; Rajbhandari, Prashant; Vergnes, Laurent; Rosenberg, Gregory M; Meng, Yonghong; Pan, Calvin; Phuong, Thuy M N; Gharakhanian, Raffi; Che, Nam; Mäkinen, Selina; Shih, Diana M; Civelek, Mete; Parks, Brian W; Kim, Eric D; Norheim, Frode; Chella Krishnan, Karthickeyan; Hasin-Brumshtein, Yehudit; Mehrabian, Margarete; Laakso, Markku; Drevon, Christian A; Koistinen, Heikki A; Tontonoz, Peter; Reue, Karen; Cantor, Rita M; Björkegren, Johan L M; Lusis, Aldons J 2018. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell metabolism, 27 5, 1138-1155.e6

Seldin, Marcus M; Kim, Eric D; Romay, Milagros C; Li, Shen; Rau, Christoph D; Wang, Jessica J; Krishnan, Karthickeyan Chella; Wang, Yibin; Deb, Arjun; Lusis, Aldons J 2017. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. American journal of physiology. Heart and circulatory physiology, 312 4, H728-H741

Chella Krishnan, Karthickeyan; Mukundan, Santhosh; Alagarsamy, Jeyashree; Hur, Junguk; Nookala, Suba; Siemens, Nikolai; Svensson, Mattias; Hyldegaard, Ole; Norrby-Teglund, Anna; Kotb, Malak 2016. Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse. PLoS pathogens, 12 7, e1005732

Chella Krishnan, Karthickeyan; Mukundan, Santhosh; Alagarsamy, Jeyashree; Laturnus, Donna; Kotb, Malak 2016. Host Genetic Variations and Sex Differences Potentiate Predisposition, Severity, and Outcomes of Group A Streptococcus-Mediated Necrotizing Soft Tissue Infections. Infection and immunity, 84 2, 416-24

Mairpady Shambat, Srikanth; Siemens, Nikolai; Monk, Ian R; Mohan, Disha B; Mukundan, Santhosh; Krishnan, Karthickeyan Chella; Prabhakara, Sushma; Snäll, Johanna; Kearns, Angela; Vandenesch, Francois; Svensson, Mattias; Kotb, Malak; Gopal, Balasubramanian; Arakere, Gayathri; Norrby-Teglund, Anna 2016. A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains. Scientific reports, 6 , 31360

Chella Krishnan, Karthickeyan; Mukundan, Santhosh; Landero Figueroa, Julio A; Caruso, Joseph A; Kotb, Malak 2014. Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications. Infection and immunity, 82 7, 2992-3001