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Photo of Pheruza Tarapore

Pheruza Tarapore

Adjunct Assistant Professor

Pathology & Laboratory Medicine | College of Medicine

  • Postdoctoral Research Assistant: University of Cincinnati College (Cell and Cancer Biology, )
  • Doctoral Degree: University of Cincinnati (Molecular Genetics)
  • Master's Degree: University of Bombay (Microbiology)
  • Bachelor's Degree: University of Bombay (Microbiology)
Contact Information
Research Interests

~~My research focuses on two separate fields Cancer therapy and Health outcomes of Endocrine disruptors.

I am part of a pilot study examining the risk of prostate cancer and testicular reprogramming following dietary fatty acid consumption and BPA exposure during prenatal development, a critical susceptible window. Additionally, the short and long term effects of low doses of endocrine disruptors on the cell centrosome duplication cycle in prostate cells, and the underlying mechanism are be...

Peer Reviewed Publications

Ho, Shuk-Mei; Rao, Rahul; To, Sarah; Schoch, Emma; Tarapore, Pheruza 2017. Bisphenol A and its analogues disrupt centrosome cycle and microtubule dynamics in prostate cancer. Endocrine-related cancer, 24 2, 83-96

Smithrud, David B; Powers, Lucas; Lunn, Jennifer; Abernathy, Scott; Peschka, Michael; Ho, Shuk-Mei; Tarapore, Pheruza 2017. Ca2+ Selective Host Rotaxane Is Highly Toxic Against Prostate Cancer Cells. ACS medicinal chemistry letters, 8 2, 163-167

Tarapore, Pheruza; Hennessy, Max; Song, Dan; Ying, Jun; Ouyang, Bin; Govindarajah, Vinothini; Leung, Yuet-Kin; Ho, Shuk-Mei 2017. High butter-fat diet and bisphenol A additively impair male rat spermatogenesis. Reproductive toxicology (Elmsford, N.Y.), 68 , 191-199

Zhou, Zilan; Kennell, Carly; Lee, Joo-Youp; Leung, Yuet-Kin; Tarapore, Pheruza 2017. Calcium phosphate-polymer hybrid nanoparticles for enhanced triple negative breast cancer treatment via co-delivery of paclitaxel and miR-221/222 inhibitors. Nanomedicine : nanotechnology, biology, and medicine, 13 2, 403-410

Tarapore, Pheruza; Hennessy, Max; Song, Dan; Ying, Jun; Ouyang, Bin; Govindarajah, Vinothini; Leung, Yuet-Kin; Ho, Shuk-Mei 2016. Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets. Data in brief, 9 , 812-817

Tarapore, Pheruza; Ying, Jun; Ouyang, Bin; Burke, Barbara; Bracken, Bruce; Ho, Shuk-Mei 2014. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PloS one, 9 3, e90332

Lee, Ming-Tsung; Ho, Shuk-Mei; Tarapore, Pheruza; Chung, Irving; Leung, Yuet-Kin 2013. Estrogen receptor beta isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), 15 11, 1262-71

Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Estrogen receptor beta (ERbeta1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. The Journal of biological chemistry, 288 35, 25038-52

Smithrud, David B; Wang, Xiaoyang; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Crown Ether Host-Rotaxanes as Cytotoxic Agents. ACS medicinal chemistry letters, 4 1, 27-31

Ho, Shuk-Mei; Johnson, Abby; Tarapore, Pheruza; Janakiram, Vinothini; Zhang, Xiang; Leung, Yuet-Kin 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR journal / National Research Council, Institute of Laboratory Animal Resources, 53 3-4, 289-305

Isaac, Jared; Tarapore, Pheruza; Zhang, Xiang; Lam, Ying-Wai; Ho, Shuk-Mei 2012. Site-specific S-nitrosylation of integrin ?6 increases the extent of prostate cancer cell migration by enhancing integrin alpha1 association and weakening adherence to laminin-1. Biochemistry, 51 48, 9689-97

Leung, Yuet-Kin; Lee, Ming-Tsung; Lam, Hung-Ming; Tarapore, Pheruza; Ho, Shuk-Mei 2012. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids, 77 7, 727-37

Tarapore, Pheruza; Hanashiro, Kazuhiko; Fukasawa, Kenji 2012. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell cycle (Georgetown, Tex.), 11 15, 2931-46

Tarapore, Pheruza; Shu, Yi; Guo, Peixuan; Ho, Shuk-Mei 2011. Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Molecular therapy : the journal of the American Society of Gene Therapy, 19 2, 386-94

Shinmura, K; Bennett, R A; Tarapore, P; Fukasawa, K 2007. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene, 26 20, 2939-44

Tarapore, Pheruza; Shinmura, Kazuya; Suzuki, Hitoshi; Tokuyama, Yukari; Kim, Song-Hee; Mayeda, Akila; Fukasawa, Kenji 2006. Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS letters, 580 2, 399-409

Mayhew, Christopher N; Bosco, Emily E; Fox, Sejal R; Okaya, Tomohisa; Tarapore, Pheruza; Schwemberger, Sandy J; Babcock, George F; Lentsch, Alex B; Fukasawa, Kenji; Knudsen, Erik S 2005. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer research, 65 11, 4568-77

Shinmura, Kazuya; Tarapore, Pheruza; Tokuyama, Yukari; George, Kyle R; Fukasawa, Kenji 2005. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS letters, 579 29, 6621-34

Tarapore, Pheruza; Fukasawa, Kenji 2002. Loss of p53 and centrosome hyperamplification. Oncogene, 21 40, 6234-40

Tarapore, Pheruza; Okuda, Masaru; Fukasawa, Kenji 2002. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell cycle (Georgetown, Tex.), 1 1, 75-81

Tarapore, P; Horn, H F; Tokuyama, Y; Fukasawa, K 2001. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene, 20 25, 3173-84

Tarapore, P; Tokuyama, Y; Horn, H F; Fukasawa, K 2001. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene, 20 47, 6851-63

Tokuyama, Y; Horn, H F; Kawamura, K; Tarapore, P; Fukasawa, K 2001. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. The Journal of biological chemistry, 276 24, 21529-37

Mussman, J G; Horn, H F; Carroll, P E; Okuda, M; Tarapore, P; Donehower, L A; Fukasawa, K 2000. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene, 19 13, 1635-46

Okuda, M; Horn, H F; Tarapore, P; Tokuyama, Y; Smulian, A G; Chan, P K; Knudsen, E S; Hofmann, I A; Snyder, J D; Bove, K E; Fukasawa, K 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, 103 1, 127-40

Tarapore, P; Fukasawa, K 2000. p53 mutation and mitotic infidelity. Cancer investigation, 18 2, 148-55

Carroll, P E; Okuda, M; Horn, H F; Biddinger, P; Stambrook, P J; Gleich, L L; Li, Y Q; Tarapore, P; Fukasawa, K 1999. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene, 18 11, 1935-44

Tarapore, P; Richmond, C; Zheng, G; Cohen, S B; Kelder, B; Kopchick, J; Kruse, U; Sippel, A E; Colmenares, C; Stavnezer, E 1997. DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. Nucleic acids research, 25 19, 3895-903